EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18426977eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.J Cell Biol2008 Apr 21Ram??rez-Valle Fdoi: 10.1083/jcb.200710215.
17601486Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.Arch Biochem Biophys2007 Sep 1Peffley DM-
19525934Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.Nat Cell Biol2009 JulSilvera Ddoi: 10.1038/ncb1900
25593313Equol, an isoflavone metabolite, regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF4G.J Biol Chem2015 Mar 6de la Parra Cdoi: 10.1074/jbc.M114.617415
27501049Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI.Lab Invest2016 SepAttar-Schneider Odoi: 10.1038/labinvest.2016.77
27162083The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.Angew Chem Int Ed Engl2016 Jun 13Salvi Ndoi: 10.1002/anie.201603254

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr3184332046Silentrs747865216Y1526Y0.06
ACCchr3184322541Splice_Regionnovel0.92
BLCAchr3184326915SilentnovelL1120L0.36
BLCAchr3184317391Missense_MutationnovelR73H0.25
BLCAchr3184321701Missense_MutationNAE373Q0.37
BLCAchr3184322690Missense_MutationnovelE585D0.45
BLCAchr31843154945'UTRrs7716049000.26
BLCAchr31843155405'UTRnovel0.26
BLCAchr3184319799Missense_MutationnovelT179A0.42
BLCAchr31843349843'UTRnovel0.38
BLCAchr3184322441SilentNAA533A0.3
BLCAchr3184317740SilentnovelP116P0.13
BLCAchr3184322056Missense_MutationnovelI491T0.26
BLCAchr3184322956Splice_SitenovelX643_splice0.48
BLCAchr3184322025Missense_MutationnovelE481Q0.15
BLCAchr3184328731Missense_MutationnovelG1352R0.59
BLCAchr3184325307Silentrs751408255I965I0.21
BLCAchr3184331294Missense_MutationnovelR1397L0.2
BLCAchr3184331582Missense_MutationnovelN1457K0.06
BLCAchr3184331948Nonsense_MutationnovelE1494*0.14
BLCAchr3184325865Missense_Mutationrs267599714L1046F0.33
BLCAchr3184323912Missense_MutationNAE803Q0.28
BLCAchr3184319692Missense_MutationNAG143D0.42
BLCAchr3184327239Missense_MutationNAG1151D0.45
BRCAchr3184327694Missense_Mutationrs73053766N1257S0.2
BRCAchr3184324921Missense_MutationnovelR888Q0.69
BRCAchr3184322420SilentnovelA526A0.08
BRCAchr3184317336Missense_MutationNAR55W0.32
BRCAchr3184317349Missense_Mutationrs571849011P59L0.3
BRCAchr3184332043Silentrs139865627L1525L0.14
BRCAchr3184320610Intronnovel0.31
BRCAchr3184323486Missense_MutationNAE723K0.26
BRCAchr3184322020Missense_MutationNAG479V0.32
BRCAchr3184334749Silentrs149243787D1547D0.3
BRCAchr3184323520Missense_MutationnovelW734L0.07
CESCchr3184331493Missense_MutationnovelE1428K0.08
CESCchr3184331293Nonsense_MutationNAR1397*0.17
CESCchr3184320844IntronNA0.22
CESCchr3184325333Missense_MutationNAR974H0.35
CESCchr3184320533Intronnovel0.38
CESCchr3184324893Missense_MutationNAR879C0.4
CESCchr3184325352Missense_MutationnovelQ980H0.37
CESCchr3184331587Missense_Mutationrs369679218R1459Q0.24
CESCchr31843352493'UTRnovel0.36
CESCchr31843352043'UTRnovel0.15
CESCchr3184321900Missense_MutationnovelS439F0.07
CESCchr3184327421Missense_MutationnovelE1212K0.15
CESCchr3184327637Missense_MutationNAS1238C0.21
CESCchr31843352483'UTRnovel0.18
CESCchr3184316103Intronnovel0.27
CESCchr3184323559Missense_Mutationrs781676030R747Q0.21
CHOLchr3184322014Missense_MutationnovelE477V0.33
CHOLchr3184322853Missense_MutationnovelK610Q0.29
COADchr3184331346SilentNAG1414G0.35
COADchr3184327338Missense_Mutationrs756664955R1184Q0.35
COADchr3184321519Missense_Mutationrs754009820R312H0.34
COADchr3184321367Silentrs374764057S261S0.28
COADchr3184320693Missense_MutationNAR201C0.15
COADchr3184326569Missense_MutationnovelG1089W0.14
COADchr3184323409Missense_MutationNAA697V0.13
COADchr3184315815Missense_MutationnovelS7P0.32
COADchr3184321970Silentrs779808419E462E0.3
COADchr3184334749Silentrs149243787D1547D0.41
COADchr3184328711Missense_MutationNAT1345I0.08
COADchr3184327847SilentNAV1266V0.42
COADchr3184327365Missense_MutationNAR1193Q0.22
COADchr3184321883Frame_Shift_InsnovelT436Hfs*400.21
COADchr3184320533Intronnovel0.38
COADchr3184327907Silentrs748359022T1286T0.48
COADchr3184316205Missense_MutationnovelS45Y0.17
COADchr3184324201Splice_Regionrs367822197L825L0.37
COADchr3184320964Missense_Mutationrs752416317T223M0.29
COADchr3184331992Silentrs112264710A1508A0.28
COADchr3184319793Missense_MutationnovelR177C0.42
COADchr3184327606Frame_Shift_DelNAP1229Qfs*20.18
COADchr3184320694Missense_Mutationrs34838305R201H0.09
COADchr3184321749Missense_MutationNAE389K0.11
COADchr3184327214Splice_SitenovelX1143_splice0.38
COADchr31843349773'UTRnovel0.38
COADchr3184327845Missense_MutationnovelV1266M0.21
COADchr3184319800Missense_MutationNAT179M0.25
COADchr3184324935Missense_MutationNAR893W0.13
ESCAchr3184315597Intronnovel0.21
ESCAchr31843146395'UTRnovel0.27
GBMchr3184325875Missense_MutationnovelD1049A0.12
GBMchr3184322863Missense_MutationnovelD613V0.04
GBMchr3184322846Missense_MutationnovelE607D0.13
GBMchr3184331586Missense_Mutationrs564880447R1459W0.64
GBMchr3184321363Missense_Mutationrs367754765S260L0.54
GBMchr3184321748Silentrs145844411S388S0.45
GBMchr3184334863Missense_MutationNAF1585L0.45MA3
GBMchr3184326553SilentNAQ1083Q0.15
HNSCchr3184320928Missense_Mutationrs762038648T211M0.29
HNSCchr3184332071Missense_MutationnovelL1535V0.17MA3
HNSCchr3184328656Missense_MutationnovelE1327K0.15
HNSCchr3184321824Missense_MutationNAD414N0.21
HNSCchr3184325273Missense_MutationnovelR954Q0.17
HNSCchr3184325355Silentrs374422548D981D0.15
HNSCchr3184325698Intronrs5459605330.37
HNSCchr3184322625Missense_Mutationrs762917023P564S0.12
HNSCchr3184323558Nonsense_MutationnovelR747*0.05
HNSCchr3184326563Missense_MutationnovelP1087S0.26
HNSCchr3184321348Missense_MutationnovelS255L0.16
HNSCchr3184325540Nonsense_MutationnovelE1008*0.28
HNSCchr3184327675Missense_MutationnovelE1251Q0.29
HNSCchr3184315424Intronnovel0.24
HNSCchr3184327979Frame_Shift_DelnovelS1311Lfs*300.06
HNSCchr3184315341Intronnovel0.38
HNSCchr3184328740Frame_Shift_InsnovelM1355Ifs*360.1
HNSCchr3184326626Missense_MutationnovelA1108T0.21
HNSCchr3184325325Silentrs553609598T971T0.16
HNSCchr3184321425Missense_MutationnovelA281S0.17
HNSCchr3184321426Missense_MutationnovelA281V0.17
HNSCchr3184325272Nonsense_MutationnovelR954*0.21
HNSCchr3184316207Nonsense_MutationnovelQ46*0.1
HNSCchr3184321548Missense_MutationNAE322K0.33
HNSCchr3184332040SilentnovelA1524A0.23
KICHchr3184320965SilentnovelT223T0.82
KIRCchr3184332024Missense_MutationNAQ1519R0.25
KIRCchr3184331345Missense_MutationNAG1414A0.46
KIRPchr3184334736Missense_MutationnovelR1543Q0.35MA3
KIRPchr3184317469Missense_MutationnovelS99F0.24
KIRPchr3184323958Missense_MutationNAM818T0.27
KIRPchr3184324997SilentnovelE913E0.35
KIRPchr3184322080Missense_Mutationrs780235176L499S0.27
LAMLchr3184326591Missense_MutationnovelG1096D0.21
LAMLchr3184326608Missense_MutationnovelG1102R0.06
LAMLchr3184321510Missense_MutationnovelE309A0.25
LGGchr3184324948Missense_MutationNAG897E0.3
LGGchr3184322679Missense_MutationnovelH582Y0.48
LGGchr3184315576Intronnovel0.37
LGGchr3184328679SilentnovelP1334P0.4
LGGchr3184325338Missense_MutationNAR976C0.36
LIHCchr3184322845Missense_MutationNAE607G0.28
LIHCchr3184321701Nonsense_MutationNAE373*0.16
LIHCchr3184327857Missense_MutationNAA1270T0.3
LIHCchr3184320915Intronnovel0.25
LIHCchr3184321762Missense_Mutationrs756637859P393R0.63
LIHCchr3184331477SilentNAV1422V0.44
LUADchr3184327949SilentnovelL1300L0.06
LUADchr3184323101Missense_MutationNAR650W0.49
LUADchr3184317716Splice_SitenovelX109_splice0.57
LUADchr3184327420SilentNAT1211T0.23
LUADchr3184328691SilentNAL1338L0.23
LUADchr3184334750Missense_MutationNAA1548S0.06MA3
LUADchr3184327252SilentNAG1155G0.28
LUADchr3184325725Intronnovel0.21
LUADchr3184327433Missense_Mutationrs201711322R1216C0.4
LUADchr3184331756Missense_MutationnovelS1475C0.16
LUADchr3184328638Missense_Mutationrs758913160E1321K0.05
LUADchr3184321454Missense_MutationnovelM290I0.28
LUADchr3184327266Missense_MutationnovelR1160P0.17
LUADchr3184325572Missense_MutationNAI1018M0.14
LUADchr3184321617Missense_MutationNAL345F0.11
LUADchr3184322574Nonsense_MutationNAQ547*0.11
LUADchr3184325615Missense_MutationNAG1033S0.13
LUADchr3184334850Missense_MutationNAS1581F0.19MA3
LUADchr3184331804Missense_MutationNAI1491N0.08
LUADchr3184324347Splice_RegionNAT873T0.15
LUADchr3184325693Intronrs7645817090.33
LUADchr3184322451Splice_SitenovelX536_splice0.48
LUADchr3184321304SilentNAI240I0.13
LUADchr3184326926Nonsense_MutationNAS1124*0.05
LUADchr3184331599Missense_MutationnovelW1463L0.12
LUADchr3184331960Nonsense_MutationNAR1498*0.04
LUSCchr3184323886Missense_MutationnovelL794R0.17
LUSCchr3184331511Missense_Mutationrs777194473G1434C0.25
LUSCchr3184320641SilentNAR183R0.2
LUSCchr3184323195Missense_Mutationrs750028797R681H0.18
LUSCchr3184323887SilentNAL794L0.08
LUSCchr3184324926Missense_Mutationrs373331022I890V0.17
LUSCchr3184327930Missense_MutationnovelR1294H0.37
LUSCchr3184316733Intronnovel0.16
LUSCchr3184320663Missense_MutationNAD191Y0.06
LUSCchr3184321606Missense_MutationNAS341Y0.06
LUSCchr3184321633Missense_MutationNAP350L0.08
LUSCchr3184321955Missense_MutationnovelM457I0.05
LUSCchr31843350103'UTRnovel0.15
LUSCchr31843350113'UTRnovel0.17
LUSCchr3184325538Missense_MutationNAK1007R0.22
LUSCchr3184324288Missense_MutationNAD854H0.04
LUSCchr3184327692SilentNAL1256L0.08
LUSCchr3184322945SilentnovelV640V0.42
LUSCchr3184321444Missense_MutationNAG287E0.24
LUSCchr3184325047Missense_MutationnovelE930G0.23
LUSCchr3184328715Frame_Shift_InsnovelI1347Nfs*440.09
LUSCchr3184317381Missense_MutationnovelA70T0.12
MESOchr3184326546Missense_MutationnovelN1081S0.09
OVchr3184320510Intronnovel0.1
OVchr3184327639Frame_Shift_DelnovelE1239Rfs*40.06
OVchr3184327413Missense_MutationNAS1209T0.32
OVchr3184324937SilentNAR893R0.15
OVchr3184321390Missense_MutationnovelS269F0.07
OVchr3184327630Missense_MutationNAA1236T0.07
OVchr3184317380SilentnovelA69A0.06
OVchr3184323509SilentNAA730A0.19
OVchr3184334804Missense_MutationNAS1566G0.17MA3
OVchr3184321364SilentnovelS260S0.12
OVchr3184320907Intronnovel0.07
OVchr3184322442Missense_MutationnovelF534L0.15
OVchr3184321838SilentNAV418V0.47
PAADchr3184321287Missense_Mutationrs760215803R235W0.03
PAADchr3184322831Missense_MutationnovelK602N0.2
PAADchr3184324289Missense_MutationnovelD854G0.16
PAADchr3184327364Missense_Mutationrs369412977R1193W0.17
PAADchr3184328689Missense_MutationnovelL1338I0.18
PAADchr3184334768Missense_Mutationrs768015986V1554M0.11MA3
PRADchr3184328707Frame_Shift_InsnovelT1345Nfs*460.41
PRADchr3184315385Intronrs3698647920.17
PRADchr3184327887Missense_Mutationrs376228156R1280W0.38
READchr3184323870Missense_MutationNAD789N0.28
READchr3184326598SilentNAS1098S0.29
READchr3184323946Missense_MutationNAA814V0.3
READchr3184320533Intronnovel0.42
READchr3184326619SilentNAP1105P0.34
READchr3184317455SilentNAI94I0.37
READchr3184321787Missense_MutationNAE401D0.4
READchr3184323469Missense_MutationNAA717D0.15
READchr3184325091Missense_MutationNAD945Y0.48
SARCchr3184321686Missense_MutationnovelE368K0.14
SARCchr3184325746Intronnovel0.46
SKCMchr3184331587Missense_Mutationrs369679218R1459Q0.7
SKCMchr3184334729Splice_RegionNAL1541L0.58
SKCMchr3184331300Missense_MutationnovelA1399V0.16
SKCMchr3184331301Silentrs777853448A1399A0.16
SKCMchr3184325338Missense_MutationNAR976C0.11
SKCMchr3184317417Missense_MutationnovelP82S0.3
SKCMchr3184322706Missense_MutationnovelE591K0.07
SKCMchr3184323802Missense_MutationnovelS766F0.39
SKCMchr3184321374Missense_MutationNAP264S0.27
SKCMchr3184317427Missense_MutationNAS85F0.28
SKCMchr3184317738Missense_MutationNAP116S0.1
SKCMchr3184317448Missense_MutationNAS92F0.14
SKCMchr3184317466Missense_MutationnovelA98V0.51
SKCMchr3184317467SilentnovelA98A0.51
SKCMchr3184325852Splice_Regionrs775684766S1041S0.21
SKCMchr3184327380Missense_MutationNAP1198L0.27
SKCMchr3184327839Nonsense_MutationNAQ1264*0.5
SKCMchr3184331485Missense_MutationNAT1425I0.25
SKCMchr3184326941Missense_Mutationrs761411054A1129V0.13
SKCMchr3184321326Missense_MutationNAP248S0.26
SKCMchr3184323464SilentNAI715I0.34
SKCMchr3184321527Missense_MutationnovelP315S0.1
SKCMchr3184320625Splice_Regionnovel0.26
SKCMchr3184325698Intronrs5459605330.48
SKCMchr3184325864Silentrs762105656P1045P0.24
SKCMchr3184322914Missense_MutationNAP630L0.46
SKCMchr3184323464SilentNAI715I0.43
SKCMchr3184321617Missense_MutationNAL345F0.07
SKCMchr3184323146Missense_MutationNAD665N0.19
SKCMchr3184331508Missense_Mutationrs147696097P1433S0.37
SKCMchr3184323170Frame_Shift_InsnovelG674Wfs*60.27
SKCMchr3184325498Nonsense_MutationnovelR994*0.31
SKCMchr3184321920Missense_MutationnovelP446S0.4
SKCMchr3184325853Missense_Mutationrs747077459R1042C0.18
SKCMchr3184323589Missense_MutationNAT757I0.16
SKCMchr3184324896SilentnovelL880L0.21
STADchr3184322585SilentNAA550A0.18
STADchr3184322687SilentNAA584A0.24
STADchr3184324883SilentnovelE875E0.22
STADchr3184321811SilentNAS409S0.36
STADchr3184325284Missense_MutationNAY958H0.25
STADchr3184325931Nonsense_MutationNAR1068*0.06
STADchr3184317721Missense_MutationNAR110H0.43
STADchr3184324894Missense_MutationNAR879H0.31
STADchr3184327624Frame_Shift_DelnovelK1234Rfs*90.08
STADchr3184323102Missense_MutationNAR650Q0.29
STADchr3184325067Missense_MutationNAR937C0.26
STADchr3184323900Missense_MutationNAD799Y0.37
STADchr3184322937Missense_MutationnovelD638N0.34
STADchr3184334750Missense_MutationnovelA1548T0.11MA3
STADchr3184323444Nonsense_MutationNAR709*0.24
STADchr31843349843'UTRnovel0.54
STADchr3184328915SilentNAI1362I0.09
STADchr3184331732Missense_MutationNAN1467I0.08
STADchr3184315436Intronnovel0.32
STADchr3184325300Frame_Shift_DelnovelI965Sfs*1270.1
STADchr3184328002Missense_MutationNAG1318E0.11
STADchr31843349783'UTRnovel0.38
STADchr3184324938Missense_MutationNAR894C0.44
STADchr3184331534Missense_MutationNAE1441D0.23
STADchr3184325339Missense_MutationNAR976H0.27
STADchr3184331967Missense_MutationNAD1500G0.27
STADchr3184320646Missense_MutationNAP185L0.13
STADchr3184326572Nonsense_MutationNAR1090*0.13
STADchr3184323486Missense_MutationNAE723K0.14
STADchr3184327914Missense_MutationNAR1289C0.3
STADchr31843349783'UTRnovel0.29
STADchr31843349783'UTRnovel0.38
STADchr3184315360Intronnovel0.23
STADchr31843349643'UTRnovel0.2
STADchr3184326556SilentNAL1084L0.1
STADchr3184321884Frame_Shift_DelNAT436Pfs*860.36
STADchr3184331992Silentrs112264710A1508A0.12
STADchr3184327906Missense_Mutationrs781371449T1286M0.48
STADchr3184321884Frame_Shift_DelNAT436Pfs*860.1
STADchr3184321794Missense_MutationnovelL404F0.18
STADchr3184326618Missense_MutationNAP1105H0.31
STADchr3184317475Missense_MutationNAG101V0.15
STADchr3184322698Missense_Mutationrs747836331Q588R0.16
STADchr3184321519Missense_Mutationrs754009820R312H0.33
THYMchr31843353093'UTRnovel0.28
UCECchr3184325373Splice_RegionNAG987G0.39
UCECchr3184324347Splice_RegionNAT873T0.08
UCECchr3184321457SilentnovelT291T0.35
UCECchr3184325725IntronNA0.24
UCECchr3184325914Missense_MutationNAR1062H0.38
UCECchr3184327253Missense_MutationNAD1156N0.34
UCECchr3184323156Missense_MutationnovelP668Q0.38
UCECchr3184321367Silentrs374764057S261S0.59
UCECchr3184322075Missense_MutationNAQ497H0.44
UCECchr3184319795SilentnovelR177R0.31
UCECchr3184320531Intronnovel0.38
UCECchr3184322615SilentnovelG560G0.1
UCECchr3184321544Silentrs112561176L320L0.45
UCECchr3184321441Missense_MutationnovelP286H0.54
UCECchr3184323414Missense_MutationnovelL699M0.05
UCECchr31843157685'UTRnovel0.46
UCECchr3184320694Missense_Mutationrs34838305R201H0.37
UCECchr3184321749Missense_MutationNAE389K0.47
UCECchr3184327653Missense_MutationnovelE1243D0.06
UCECchr3184315614Intronnovel0.44
UCECchr31843352063'UTRnovel0.5
UCECchr3184321749Missense_MutationNAE389K0.54
UCECchr3184326920Missense_MutationnovelR1122H0.45
UCECchr3184327241Missense_MutationnovelE1152K0.36
UCECchr3184334867Missense_MutationnovelK1587E0.47MA3
UCECchr3184317801Nonsense_MutationnovelE137*0.1
UCECchr3184326928Missense_MutationNAA1125S0.25
UCECchr31843349433'UTRnovel0.52
UCECchr3184320533Intronnovel0.58
UCECchr3184321548Missense_MutationNAE322K0.27
UCECchr31843349783'UTRnovel0.45
UCECchr3184317786Missense_MutationnovelG132S0.22
UCECchr3184321547Silentrs780652746A321A0.12
UCECchr3184328963Missense_MutationnovelE1378D0.16
UCECchr31843349893'UTRnovel0.26
UCECchr3184327898SilentnovelV1283V0.26
UCECchr3184331999Silentrs557210676L1511L0.44
UCECchr3184325740Intronnovel0.37
UCECchr3184320634Missense_MutationnovelR181Q0.12
UCECchr3184327433Missense_MutationnovelR1216S0.28
UCECchr3184328943Missense_MutationnovelA1372S0.37
UCECchr3184331785Missense_MutationnovelA1485T0.35
UCECchr3184315185Intronnovel0.5
UCECchr3184321519Missense_Mutationrs754009820R312H0.37
UCECchr3184325324Missense_Mutationrs767404672T971M0.42
UCECchr3184325496Missense_MutationnovelR993H0.43
UCECchr3184323100SilentnovelL649L0.08
UCECchr3184331353Missense_Mutationrs758267267V1417I0.41
UCECchr3184327376Missense_Mutationrs113388242R1197W0.41
UCECchr3184324277Missense_MutationnovelE850A0.26
UCECchr3184327592Missense_MutationnovelR1223Q0.25
UCECchr3184317754Missense_MutationnovelP121H0.3
UCECchr3184321342Missense_MutationnovelS253I0.48
UCECchr3184323574Missense_MutationnovelA752G0.23
UCECchr3184334767Silentrs369644486D1553D0.53
UCECchr3184323445Missense_MutationnovelR709Q0.53
UCECchr3184323594Splice_SitenovelX758_splice0.67
UCECchr3184316135Missense_MutationnovelA22T0.79
UCECchr3184321862Missense_MutationnovelK426N0.31
UCECchr3184323456Missense_MutationNAR713C0.35
UCECchr3184322050Missense_MutationnovelT489I0.31
UCECchr3184323496Missense_MutationnovelK726T0.45
UCECchr3184325852Splice_Regionrs775684766S1041S0.4
UCECchr31843352063'UTRnovel0.37
UCECchr3184327401Missense_Mutationrs112176450R1205H0.46
UCECchr31843351783'UTRnovel0.43
UCECchr3184325604Missense_MutationnovelD1029G0.15
UCECchr31843352063'UTRnovel0.51
UCECchr3184325932Missense_MutationnovelR1068Q0.31
UCECchr3184328700Silentrs762740314A1341A0.33
UCECchr31843349663'UTRrs5278534660.3
UCECchr31843352073'UTRnovel0.65
UCECchr3184322631Missense_Mutationrs145521479R566C0.2
UCECchr31843349853'UTRnovel0.08
UCECchr31843352063'UTRnovel0.51
UCECchr3184315416Intronnovel0.36
UCECchr3184324265Missense_Mutationrs774374620R846Q0.41
UCECchr3184325333Missense_MutationNAR974H0.24
UCECchr3184321587Missense_MutationnovelV335I0.31
UCECchr3184327241Missense_MutationnovelE1152K0.48
UCECchr3184320639Nonsense_MutationNAR183*0.29
UCECchr3184324265Missense_Mutationrs774374620R846Q0.08
UCECchr3184320639Nonsense_MutationNAR183*0.2
UCECchr3184331338Missense_MutationnovelD1412Y0.19
UCECchr3184322632Missense_MutationnovelR566H0.33
UCECchr31843352063'UTRnovel0.27
UCECchr3184320702Missense_MutationnovelS204T0.09
UCECchr3184325725IntronNA0.37
UCECchr3184327449Splice_SitenovelX1221_splice0.5
UCECchr31843349783'UTRnovel0.4
UCECchr3184327630Missense_MutationNAA1236T0.07
UCECchr3184320639Nonsense_MutationNAR183*0.47
UCECchr3184321668Missense_MutationNAN362D0.41
UCECchr3184327439Missense_Mutationrs570589392R1218W0.33
UCECchr3184331302Missense_Mutationrs149821418G1400R0.11
UCECchr3184323964Missense_MutationnovelR820H0.16
UCECchr3184325329Missense_MutationnovelS973P0.12
UCECchr3184327591Nonsense_MutationNAR1223*0.15
UCECchr3184327964SilentnovelL1305L0.26
UCECchr3184315422Intronnovel0.46
UCECchr3184326971Missense_MutationnovelR1139H0.47
UCECchr3184327656Missense_MutationnovelK1244N0.32
UCECchr3184328616Intronnovel0.4
UCECchr3184334735Missense_MutationnovelR1543W0.54MA3
UCECchr3184323828Missense_MutationNAM775V0.47
UCECchr3184320638SilentNAI182I0.18
UCECchr3184323412Missense_MutationNAG698D0.33
UCECchr3184324894Missense_MutationNAR879H0.33
UCECchr3184327360Missense_MutationNAE1191D0.27
UCECchr3184334850Missense_MutationNAS1581F0.18MA3
UCECchr3184319751Missense_MutationnovelV163F0.4
UCECchr31843353043'UTRnovel0.43
UCECchr3184323594Splice_SitenovelX758_splice0.31
UCECchr3184331356Missense_Mutationrs368372465A1418T0.33
UCSchr3184328691Frame_Shift_InsnovelE1342Dfs*30.2
UCSchr3184320846Intronnovel0.11

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.44120.0018563
KIRCAMP0.11932.0306e-05
KIRPAMP0.32640.15981
LGGAMP0.03310.0013532
LUADDEL0.17640.010111
PAADAMP0.10330.16151
SARCDEL0.15560.0086757
TGCTAMP0.25337.0307e-05

Survival Analysis
CancerP-value Q-value
SARC0.0026

Kaplan-Meier Survival Analysis

HNSC0.016

Kaplan-Meier Survival Analysis

SKCM0.0073

Kaplan-Meier Survival Analysis

PRAD0.0054

Kaplan-Meier Survival Analysis

BRCA0.01

Kaplan-Meier Survival Analysis

ESCA0.043

Kaplan-Meier Survival Analysis

KIRP0.021

Kaplan-Meier Survival Analysis

PAAD0.00029

Kaplan-Meier Survival Analysis

BLCA0.005

Kaplan-Meier Survival Analysis

LAML0.019

Kaplan-Meier Survival Analysis

UCEC0.024

Kaplan-Meier Survival Analysis

LIHC0.016

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.0003

Kaplan-Meier Survival Analysis

UVM0.00055

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000114867 (Gene tree)
Gene ID
1981
Gene Symbol
EIF4G1
Alias
p220|PARK18|EIF4G|EIF4F
Full Name
eukaryotic translation initiation factor 4 gamma 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
20,864 bases
Position
chr3:184,314,495-184,335,358
Accession
3296
RBP type
canonical RBP
Summary
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000404754MA3PF02847.171.8e-2911
ENSP00000411826MA3PF02847.171.8e-2911
ENSP00000317600MA3PF02847.172e-2911
ENSP00000399858MA3PF02847.172e-2911
ENSP00000376320MA3PF02847.172.1e-2911
ENSP00000407682MA3PF02847.172.1e-2911
ENSP00000391935MA3PF02847.172.3e-2911
ENSP00000395974MA3PF02847.172.3e-2911
ENSP00000316879MA3PF02847.172.5e-2911
ENSP00000343450MA3PF02847.172.5e-2911
ENSP00000338020MA3PF02847.172.5e-2911
ENSP00000371767MA3PF02847.172.5e-2911
ENSP00000416255MA3PF02847.172.5e-2911
ENSP00000404754MIF4GPF02854.191.5e-6811
ENSP00000411826MIF4GPF02854.191.5e-6811
ENSP00000317600MIF4GPF02854.191.6e-6811
ENSP00000399858MIF4GPF02854.191.6e-6811
ENSP00000376320MIF4GPF02854.191.7e-6811
ENSP00000407682MIF4GPF02854.191.7e-6811
ENSP00000391935MIF4GPF02854.191.8e-6811
ENSP00000395974MIF4GPF02854.191.8e-6811
ENSP00000316879MIF4GPF02854.191.9e-6811
ENSP00000343450MIF4GPF02854.191.9e-6811
ENSP00000338020MIF4GPF02854.191.9e-6811
ENSP00000371767MIF4GPF02854.191.9e-6811
ENSP00000416255MIF4GPF02854.191.9e-6811
ENSP00000403269MIF4GPF02854.192.4e-5811
ENSP00000398145MIF4GPF02854.195e-4211
ENSP00000413159MIF4GPF02854.197.5e-2611
ENSP00000391412MIF4GPF02854.192.6e-1811
ENSP00000392908MIF4GPF02854.196.8e-0911
ENSP00000404754W2PF02020.189.6e-1811
ENSP00000411826W2PF02020.189.6e-1811
ENSP00000317600W2PF02020.189.8e-1811
ENSP00000399858W2PF02020.189.9e-1811
ENSP00000376320W2PF02020.181e-1711
ENSP00000407682W2PF02020.181e-1711
ENSP00000391935W2PF02020.181.1e-1711
ENSP00000395974W2PF02020.181.1e-1711
ENSP00000316879W2PF02020.181.1e-1711
ENSP00000343450W2PF02020.181.1e-1711
ENSP00000338020W2PF02020.181.1e-1711
ENSP00000371767W2PF02020.181.1e-1711
ENSP00000416255W2PF02020.181.1e-1711
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15528191Interaction between the NH2-terminal domain of eIF4A and the central domain of eIF4G modulates RNA-stimulated ATPase activity.J Biol Chem2005 Jan 21Korneeva NL-
25463438Distinct features of cap binding by eIF4E1b proteins.J Mol Biol2015 Jan 30Kubacka Ddoi: 10.1016/j.jmb.2014.11.009
11022043Mutually cooperative binding of eukaryotic translation initiation factor (eIF) 3 and eIF4A to human eIF4G-1.J Biol Chem2000 Dec 29Korneeva NL-
15220445Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein.J Virol2004 JulCuesta R-
19114555Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.Mol Cell Biol2009 MarYanagiya Adoi: 10.1128/MCB.01187-08
11214172Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.RNA2001 JanDe Gregorio E-
10507322Rhinovirus 2A proteinase mediated stimulation of rhinovirus RNA translation is additive to the stimulation effected by cellular RNA binding proteins.Virus Res1999 AugHunt SL-
24157614Depletion of hnRNP A2/B1 overrides the nuclear retention of the HIV-1 genomic RNA.RNA Biol2013 NovGordon Hdoi: 10.4161/rna.26542
9755181Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F.EMBO J1998 Oct 1Piron M-
10364288Identification of the RNA-binding, dimerization, and eIF4GI-binding domains of rotavirus nonstructural protein NSP3.J Virol1999 JulPiron M-
22467875Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs.J Biol Chem2012 Jun 8Rajagopal Vdoi: 10.1074/jbc.M112.347278
21489987Active participation of cellular chaperone Hsp90 in regulating the function of rotavirus nonstructural protein 3 (NSP3).J Biol Chem2011 Jun 3Dutta Ddoi: 10.1074/jbc.M111.231878
21139564Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1PABP mRNPs in vivo.EMBO J2011 Jan 19Park EHdoi: 10.1038/emboj.2010.312
30603102SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists.Cell Discov2019 Jan 1Yang Xdoi: 10.1038/s41421-018-0068-4
30905816tRNA-derived fragments and tRNA halves: The new players in cancers.Cancer Lett2019 Jun 28Zhu Ldoi: 10.1016/j.canlet.2019.03.012
12682023Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning.EMBO J2003 Apr 15Prevot D-
10888646Efficient translation of rotavirus mRNA requires simultaneous interaction of NSP3 with the eukaryotic translation initiation factor eIF4G and the mRNA 3' end.J Virol2000 AugVende P-
15784845Chemical-based translational induction of luciferase expression: an efficient tool for in vivo screening of protein farnesylation inhibitors.Mol Pharmacol2005 JunBoijoux O-
15192697Pharmacological-based translational induction of transgene expression in mammalian cells.EMBO Rep2004 JulBoutonnet C-
19835415How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model.Biochemistry2009 Nov 17Spirin ASdoi: 10.1021/bi901379a.
18692164Effects of poly(A)-binding protein on the interactions of translation initiation factor eIF4F and eIF4F.4B with internal ribosome entry site (IRES) of tobacco etch virus RNA.Biochim Biophys Acta2008 OctKhan MAdoi: 10.1016/j.bbagrm.2008.07.004
18490513Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.J Cell Biol2008 May 19Kawahara Hdoi: 10.1083/jcb.200708004.
18296639PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.Proc Natl Acad Sci U S A2008 Mar 4Suzuki Cdoi: 10.1073/pnas.0712235105
18005740Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions.Cell Host Microbe2007 Oct 11Katsafanas GC-
17588515Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p.Mol Cell2007 Jun 22Paquin N-
22718971eIF4E-binding protein regulation of mRNAs with differential 5'-UTR secondary structure: a polyelectrostatic model for a component of protein-mRNA interactions.Nucleic Acids Res2012 SepCawley Adoi: 10.1093/nar/gks511
21576267Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex.Genes Dev2011 May 15Alexandrov Adoi: 10.1101/gad.2045411.
20659017Inhibition of translation initiation following glucose depletion in yeast facilitates a rationalization of mRNA content.Biochem Soc Trans2010 AugLui Jdoi: 10.1042/BST0381131.
27899360Widespread and dynamic translational control of red blood cell development.Blood2017 Feb 2Alvarez-Dominguez JRdoi: 10.1182/blood-2016-09-741835
28242763Eukaryotic translation initiation factor 4G (eIF4G) coordinates interactions with eIF4A, eIF4B, and eIF4E in binding and translation of the barley yellow dwarf virus 3' cap-independent translation element (BTE).J Biol Chem2017 Apr 7Zhao Pdoi: 10.1074/jbc.M116.764902
27668427Characterization of the Expression of the RNA Binding Protein eIF4G1 and Its Clinicopathological Correlation with Serous Ovarian Cancer.PLoS One2016 Sep 26Li Ldoi: 10.1371/journal.pone.0163447
24063684Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms.Diagn Pathol2013 Sep 24Souii Adoi: 10.1186/1746-1596-8-161.
27525590An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation.Nat Struct Mol Biol2016 SepImai Sdoi: 10.1038/nsmb.3280
28546148Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs.RNA2017 SepZinshteyn Bdoi: 10.1261/rna.062059.117
9548260Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.Nature1998 Apr 2Craig AW-
17095505Picornavirus internal ribosome entry site elements can stimulate translation of upstream genes.J Biol Chem2007 Jan 5Junemann C-
18977752Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc.J Biol Chem2008 Dec 26Cheng Sdoi: 10.1074/jbc.M807716200
15694484Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues.Mol Biochem Parasitol2005 MarDhalia R-
19751846Isolation and functional characterization of eIF4F components and poly(A)-binding protein from Plasmodium falciparum.Parasitol Int2009 DecTuteja Rdoi: 10.1016/j.parint.2009.09.001
18367715Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking.RNA2008 MayLindqvist Ldoi: 10.1261/rna.971208
20507975Tombusvirus recruitment of host translational machinery via the 3' UTR.RNA2010 JulNicholson BLdoi: 10.1261/rna.2135210
24961997Magnesium-dependent folding of a picornavirus IRES element modulates RNA conformation and eIF4G interaction.FEBS J2014 AugLozano Gdoi: 10.1111/febs.12890
26384734NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII.Protein Sci2015 DecAumayr Mdoi: 10.1002/pro.2807
28757063ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.Bioorg Med Chem Lett2017 Sep 1Tillotson Jdoi: 10.1016/j.bmcl.2017.07.045
12952955Identification of a C-terminal poly(A)-binding protein (PABP)-PABP interaction domain: role in cooperative binding to poly (A) and efficient cap distal translational repression.J Biol Chem2003 Nov 21Melo EO-
12581158Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules.Genes Cells2003 FebHashemzadeh-Bonehi L-
11483729Activity of the hepatitis A virus IRES requires association between the cap-binding translation initiation factor (eIF4E) and eIF4G.J Virol2001 SepAli IK-
11113094Regulation of the initiation of pancreatic digestive enzyme protein synthesis by cholecystokinin in rat pancreas in vivo.Gastroenterology2000 DecBragado MJ-
19641745Identification and bioinformatics characterization of translation initiation complex eIF4F components and poly(A)-binding protein from Plasmodium falciparum.Commun Integr Biol2009 MayTuteja R-
18386287Regulation of cap-dependent translation initiation in the early stage porcine parthenotes.Mol Reprod Dev2008 DecSusor Adoi: 10.1002/mrd.20913.
17329400ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.Am J Physiol Cell Physiol2007 JulFuchs BC-
17012235Tobacco etch virus mRNA preferentially binds wheat germ eukaryotic initiation factor (eIF) 4G rather than eIFiso4G.J Biol Chem2006 Nov 24Ray S-
25673016In vitro-reduced translation efficiency of coxsackievirus B3 Sabin3-like strain is correlated to impaired binding of cellular initiation factors to viral IRES RNA.Curr Microbiol2015 MayBen M'hadheb Mdoi: 10.1007/s00284-015-0784-z
27313212Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP.Proc Natl Acad Sci U S A2016 Jul 5Ruoff Rdoi: 10.1073/pnas.1605451113
10216942Protein synthesis initiation factor 4G.Int J Biochem Cell Biol1999 JanKeiper BD-
9418852RNA recognition motif 2 of yeast Pab1p is required for its functional interaction with eukaryotic translation initiation factor 4G.Mol Cell Biol1998 JanKessler SH-
11565745IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII.RNA2001 SepLopez de Quinto S-
11257179Functional interaction of translation initiation factor eIF4G with the foot-and-mouth disease virus internal ribosome entry site.J Gen Virol2001 AprSaleh L-
11060291Characterization of the two eIF4A-binding sites on human eIF4G-1.J Biol Chem2001 Jan 26Korneeva NL-
10913184Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation.Mol Cell Biol2000 AugLomakin IB-
10887196Stabilization of eukaryotic initiation factor 4E binding to the mRNA 5'-Cap by domains of eIF4G.J Biol Chem2000 Sep 29von Der Haar T-
10872469eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.Annu Rev Biochem1999Gingras AC-
10747998The phosphorylation state of poly(A)-binding protein specifies its binding to poly(A) RNA and its interaction with eukaryotic initiation factor (eIF) 4F, eIFiso4F, and eIF4B.J Biol Chem2000 Jun 9Le H-
16322461Structural roles for human translation factor eIF3 in initiation of protein synthesis.Science2005 Dec 2Siridechadilok B-
16287867Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation.Mol Cell Biol2005 DecSvitkin YV-
16166382Structural basis for the enhancement of eIF4A helicase activity by eIF4G.Genes Dev2005 Sep 15Oberer M-
15302949Sequence and secondary structure requirements in a highly conserved element for foot-and-mouth disease virus internal ribosome entry site activity and eIF4G binding.J Gen Virol2004 SepBassili G-
14645908PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes.J Gen Virol2003 DecBurgui I-
20169188Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development.PLoS Pathog2010 Feb 12Mair GRdoi: 10.1371/journal.ppat.1000767.
19114715MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation.J Biol Chem2009 Mar 6Unhavaithaya Ydoi: 10.1074/jbc.M809104200
18250159Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.Mol Cell Biol2008 AprWalsh Ddoi: 10.1128/MCB.01631-07
17913647In vitro reconstitution and biochemical characterization of translation initiation by internal ribosomal entry.Methods Enzymol2007Kolupaeva VG-
17766253A specific role for the C-terminal region of the Poly(A)-binding protein in mRNA decay.Nucleic Acids Res2007Simon E-
17606619eIF4G, eIFiso4G, and eIF4B bind the poly(A)-binding protein through overlapping sites within the RNA recognition motif domains.J Biol Chem2007 Aug 31Cheng S-
17584618Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.Chem Biol2007 JunLow WK-
23325513Backbone resonance assignment of the HEAT1-domain of the human eukaryotic translation initiation factor 4GI.Biomol NMR Assign2014 AprAkabayov SRdoi: 10.1007/s12104-013-9459-5
23285195Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules.PLoS One2012Rojas Mdoi: 10.1371/journal.pone.0052824
21118117Manipulation of the host translation initiation complex eIF4F by DNA viruses.Biochem Soc Trans2010 DecWalsh Ddoi: 10.1042/BST0381511.
20948310eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways.Cell Cycle2010 Oct 15Shahbazian D-
25255371Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex.Biochemistry2014 Oct 21Akabayov SRdoi: 10.1021/bi500600m
25079330eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.Nature2014 Sep 4Boussemart Ldoi: 10.1038/nature13572
24929364(1)H, (13)C, and (15)N backbone and sidechain chemical shift assignments for the HEAT2 domain of human eIF4GI.Biomol NMR Assign2015 AprEdmonds KAdoi: 10.1007/s12104-014-9564-0
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Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000411531EIF4G1-2074683-ENSP000003959741560 (aa)-E7EUU4
ENST00000346169EIF4G1-2025516-ENSP000003168791599 (aa)-Q04637
ENST00000475721EIF4G1-2331271--- (aa)--
ENST00000482303EIF4G1-235493--- (aa)--
ENST00000484862EIF4G1-236590--- (aa)--
ENST00000450424EIF4G1-2262658-ENSP00000391412833 (aa)-C9J2Z7
ENST00000455679EIF4G1-227542-ENSP0000041584287 (aa)-C9JIH5
ENST00000441154EIF4G1-2214311-ENSP000003998581436 (aa)-E7EX73
ENST00000426123EIF4G1-2132907-ENSP00000403269903 (aa)-C9JF13
ENST00000428387EIF4G1-217524-ENSP00000411707143 (aa)-C9J556
ENST00000434061EIF4G1-2185026-ENSP000004118261404 (aa)-Q04637
ENST00000456033EIF4G1-228694-ENSP00000415943160 (aa)-C9JHW9
ENST00000352767EIF4G1-2045484-ENSP000003380201606 (aa)-Q04637
ENST00000485712EIF4G1-237474--- (aa)--
ENST00000435046EIF4G1-2194668-ENSP000004047541403 (aa)-Q04637
ENST00000427845EIF4G1-2165038-ENSP000004076821513 (aa)-E9PGM1
ENST00000382330EIF4G1-2055129-ENSP000003717671606 (aa)-Q04637
ENST00000427607EIF4G1-215596-ENSP00000409545163 (aa)-C9JSU8
ENST00000350481EIF4G1-2034990-ENSP000003176001435 (aa)-Q04637
ENST00000442406EIF4G1-2225129-ENSP0000040035150 (aa)-F8WCF2
ENST00000466311EIF4G1-232573--- (aa)--
ENST00000448284EIF4G1-225677-ENSP00000392908226 (aa)-H7C044
ENST00000493299EIF4G1-238559--- (aa)--
ENST00000427141EIF4G1-214730-ENSP0000041121492 (aa)-C9J987
ENST00000460829EIF4G1-2301804--- (aa)--
ENST00000478291EIF4G1-234564--- (aa)--
ENST00000444134EIF4G1-223558-ENSP00000407244127 (aa)-C9JWH7
ENST00000464548EIF4G1-231637--- (aa)--
ENST00000422614EIF4G1-211750-ENSP00000396888180 (aa)-H7C0V6
ENST00000421110EIF4G1-2102755-ENSP00000413159869 (aa)-C9K073
ENST00000457456EIF4G1-229983-ENSP00000399969285 (aa)-C9JWW9
ENST00000342981EIF4G1-2015667-ENSP000003434501600 (aa)-Q04637
ENST00000424196EIF4G1-2125653-ENSP000004162551606 (aa)-Q04637
ENST00000413967EIF4G1-2082808-ENSP0000039075571 (aa)-F8WB97
ENST00000392537EIF4G1-2065229-ENSP000003763201512 (aa)-Q04637
ENST00000440448EIF4G1-220578-ENSP00000407240143 (aa)-C9JWH9
ENST00000444861EIF4G1-2242384-ENSP00000398145757 (aa)-C9J6B6
ENST00000414031EIF4G1-2095569-ENSP000003919351559 (aa)-Q04637
Gene Model
Click here to download ENSG00000114867's gene model file
Pathways
Pathway IDPathway NameSource
hsa03013RNA transportKEGG
hsa05416Viral myocarditisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000114867Menarche3E-1225231870
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000114867rs9393173184328011GMenarche (age at onset)25231870[0.028-0.052] unit increase0.04EFO_0004703
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114867's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000114867EIF4G19653.933ENSG00000075151EIF4G38959.768
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000114867EIF4G17684.211ENSAPOG00000021380-6864.274Acanthochromis_polyacanthus
ENSG00000114867EIF4G110097.826ENSAMEG00000017091EIF4G19993.556Ailuropoda_melanoleuca
ENSG00000114867EIF4G19264.242ENSACIG00000020879EIF4G110064.122Amphilophus_citrinellus
ENSG00000114867EIF4G19964.831ENSACIG00000014458-9955.323Amphilophus_citrinellus
ENSG00000114867EIF4G18875.000ENSAOCG00000005197EIF4G16866.130Amphiprion_ocellaris
ENSG00000114867EIF4G18080.000ENSAOCG00000010668-7065.559Amphiprion_ocellaris
ENSG00000114867EIF4G17981.579ENSAPEG00000007167-8765.903Amphiprion_percula
ENSG00000114867EIF4G18875.000ENSATEG00000020821EIF4G18759.837Anabas_testudineus
ENSG00000114867EIF4G18082.500ENSATEG00000011149-7663.828Anabas_testudineus
ENSG00000114867EIF4G19977.391ENSAPLG00000008628EIF4G110075.248Anas_platyrhynchos
ENSG00000114867EIF4G19491.489ENSACAG00000002120EIF4G110065.956Anolis_carolinensis
ENSG00000114867EIF4G1100100.000ENSANAG00000029514EIF4G110097.264Aotus_nancymaae
ENSG00000114867EIF4G18280.488ENSACLG00000014482EIF4G19660.840Astatotilapia_calliptera
ENSG00000114867EIF4G19261.905ENSACLG00000023682-8662.305Astatotilapia_calliptera
ENSG00000114867EIF4G17686.842ENSAMXG00000019345eif4g1a8364.199Astyanax_mexicanus
ENSG00000114867EIF4G18082.500ENSAMXG00000011801-7966.065Astyanax_mexicanus
ENSG00000114867EIF4G1100100.000ENSBTAG00000012881EIF4G110093.734Bos_taurus
ENSG00000114867EIF4G1100100.000ENSCJAG00000014999EIF4G110097.378Callithrix_jacchus
ENSG00000114867EIF4G110097.701ENSCAFG00000012687EIF4G19694.113Canis_familiaris
ENSG00000114867EIF4G110097.701ENSCAFG00020002517EIF4G110094.455Canis_lupus_dingo
ENSG00000114867EIF4G1100100.000ENSCHIG00000009775EIF4G110093.238Capra_hircus
ENSG00000114867EIF4G1100100.000ENSTSYG00000004963EIF4G110094.603Carlito_syrichta
ENSG00000114867EIF4G19982.456ENSCAPG00000009256-9982.295Cavia_aperea
ENSG00000114867EIF4G110097.701ENSCPOG00000007336EIF4G110090.206Cavia_porcellus
ENSG00000114867EIF4G1100100.000ENSCCAG00000037187EIF4G110097.252Cebus_capucinus
ENSG00000114867EIF4G1100100.000ENSCATG00000009656EIF4G110098.755Cercocebus_atys
ENSG00000114867EIF4G110096.552ENSCLAG00000012942EIF4G110091.496Chinchilla_lanigera
ENSG00000114867EIF4G110099.301ENSCSAG00000013704EIF4G110098.659Chlorocebus_sabaeus
ENSG00000114867EIF4G19998.222ENSCHOG00000001717EIF4G18795.918Choloepus_hoffmanni
ENSG00000114867EIF4G110090.805ENSCPBG00000015547EIF4G18069.341Chrysemys_picta_bellii
ENSG00000114867EIF4G1100100.000ENSCANG00000033182EIF4G110098.438Colobus_angolensis_palliatus
ENSG00000114867EIF4G110097.701ENSCGRG00001024063Eif4g110091.186Cricetulus_griseus_chok1gshd
ENSG00000114867EIF4G110097.701ENSCGRG00000014387Eif4g110091.186Cricetulus_griseus_crigri
ENSG00000114867EIF4G17486.486ENSCSEG00000016729-10058.006Cynoglossus_semilaevis
ENSG00000114867EIF4G19643.981ENSCSEG00000021680-9151.795Cynoglossus_semilaevis
ENSG00000114867EIF4G18478.571ENSCSEG00000005344EIF4G17080.435Cynoglossus_semilaevis
ENSG00000114867EIF4G19965.801ENSCVAG00000004437-7858.594Cyprinodon_variegatus
ENSG00000114867EIF4G17483.784ENSCVAG00000001940EIF4G19359.518Cyprinodon_variegatus
ENSG00000114867EIF4G19959.449ENSDARG00000101256CABZ01085052.17765.844Danio_rerio
ENSG00000114867EIF4G19259.880ENSDARG00000116712CABZ01061894.18667.380Danio_rerio
ENSG00000114867EIF4G19258.182ENSDARG00000006200eif4g1a8664.948Danio_rerio
ENSG00000114867EIF4G110097.826ENSDNOG00000002245EIF4G19993.912Dasypus_novemcinctus
ENSG00000114867EIF4G19998.222ENSDORG00000010226Eif4g110093.080Dipodomys_ordii
ENSG00000114867EIF4G110090.426ENSETEG00000004220EIF4G17895.789Echinops_telfairi
ENSG00000114867EIF4G19064.815ENSEBUG00000011566-6353.473Eptatretus_burgeri
ENSG00000114867EIF4G1100100.000ENSEASG00005014019EIF4G110094.583Equus_asinus_asinus
ENSG00000114867EIF4G1100100.000ENSECAG00000008046EIF4G110094.521Equus_caballus
ENSG00000114867EIF4G19995.556ENSEEUG00000003921EIF4G19198.000Erinaceus_europaeus
ENSG00000114867EIF4G19765.351ENSELUG00000006126-9955.106Esox_lucius
ENSG00000114867EIF4G19858.261ENSELUG00000015157EIF4G19954.347Esox_lucius
ENSG00000114867EIF4G110098.851ENSFCAG00000007794EIF4G110094.334Felis_catus
ENSG00000114867EIF4G110083.696ENSFALG00000008063EIF4G17569.745Ficedula_albicollis
ENSG00000114867EIF4G110098.851ENSFDAG00000005171EIF4G110091.963Fukomys_damarensis
ENSG00000114867EIF4G19069.524ENSFHEG00000023106-8063.619Fundulus_heteroclitus
ENSG00000114867EIF4G18184.615ENSGMOG00000010339-7779.070Gadus_morhua
ENSG00000114867EIF4G18483.333ENSGMOG00000009362-7963.836Gadus_morhua
ENSG00000114867EIF4G110087.356ENSGALG00000008520EIF4G17869.898Gallus_gallus
ENSG00000114867EIF4G19069.048ENSGAFG00000021346-6761.751Gambusia_affinis
ENSG00000114867EIF4G18872.727ENSGAFG00000000356EIF4G16666.173Gambusia_affinis
ENSG00000114867EIF4G19463.866ENSGACG00000013527-9855.160Gasterosteus_aculeatus
ENSG00000114867EIF4G110090.805ENSGAGG00000022694EIF4G17571.101Gopherus_agassizii
ENSG00000114867EIF4G19253.846ENSGAGG00000015279-8959.140Gopherus_agassizii
ENSG00000114867EIF4G1100100.000ENSGGOG00000013919EIF4G110099.315Gorilla_gorilla
ENSG00000114867EIF4G19261.905ENSHBUG00000003622-7163.345Haplochromis_burtoni
ENSG00000114867EIF4G18478.571ENSHBUG00000016690EIF4G18462.589Haplochromis_burtoni
ENSG00000114867EIF4G110089.655ENSHGLG00000012341-9979.067Heterocephalus_glaber_female
ENSG00000114867EIF4G19988.372ENSHGLG00000001268-10080.709Heterocephalus_glaber_female
ENSG00000114867EIF4G110090.805ENSHGLG00000011498-9977.476Heterocephalus_glaber_female
ENSG00000114867EIF4G110090.805ENSHGLG00000002390-9977.167Heterocephalus_glaber_female
ENSG00000114867EIF4G19791.818ENSHGLG00000008713-10086.687Heterocephalus_glaber_female
ENSG00000114867EIF4G110098.851ENSHGLG00000013899-10090.785Heterocephalus_glaber_female
ENSG00000114867EIF4G19989.778ENSHGLG00000020570-9993.478Heterocephalus_glaber_female
ENSG00000114867EIF4G19295.652ENSHGLG00100020527-9993.478Heterocephalus_glaber_male
ENSG00000114867EIF4G19983.556ENSHGLG00100011256-10084.100Heterocephalus_glaber_male
ENSG00000114867EIF4G110090.805ENSHGLG00100007797-9967.746Heterocephalus_glaber_male
ENSG00000114867EIF4G110098.851ENSHGLG00100015723-9293.421Heterocephalus_glaber_male
ENSG00000114867EIF4G110086.957ENSHGLG00100006409-10077.861Heterocephalus_glaber_male
ENSG00000114867EIF4G110089.655ENSHGLG00100019006-9482.178Heterocephalus_glaber_male
ENSG00000114867EIF4G18868.182ENSHCOG00000016075EIF4G19955.077Hippocampus_comes
ENSG00000114867EIF4G18077.500ENSHCOG00000013552-6761.665Hippocampus_comes
ENSG00000114867EIF4G17684.211ENSIPUG00000014754eif4g1a9856.382Ictalurus_punctatus
ENSG00000114867EIF4G19958.577ENSIPUG00000015470-8552.106Ictalurus_punctatus
ENSG00000114867EIF4G18085.000ENSIPUG00000018901eif4g17265.009Ictalurus_punctatus
ENSG00000114867EIF4G110097.701ENSSTOG00000021912EIF4G110093.994Ictidomys_tridecemlineatus
ENSG00000114867EIF4G19291.515ENSJJAG00000012185Eif4g19987.925Jaculus_jaculus
ENSG00000114867EIF4G19067.130ENSKMAG00000011791-8361.021Kryptolebias_marmoratus
ENSG00000114867EIF4G18872.727ENSKMAG00000014269-10056.780Kryptolebias_marmoratus
ENSG00000114867EIF4G18478.571ENSLBEG00000017538EIF4G16881.818Labrus_bergylta
ENSG00000114867EIF4G19258.929ENSLBEG00000018553-9960.790Labrus_bergylta
ENSG00000114867EIF4G19482.979ENSLACG00000004851EIF4G110062.738Latimeria_chalumnae
ENSG00000114867EIF4G19773.214ENSLOCG00000008729EIF4G19370.609Lepisosteus_oculatus
ENSG00000114867EIF4G110097.701ENSLAFG00000005471EIF4G19991.543Loxodonta_africana
ENSG00000114867EIF4G1100100.000ENSMFAG00000034331EIF4G110098.692Macaca_fascicularis
ENSG00000114867EIF4G1100100.000ENSMMUG00