EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27754848Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature.Cancer Res2016 Dec 15Gilles ME-
22693611Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.PLoS One2012Litchfield LMdoi: 10.1371/journal.pone.0038278
21203423Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization.PLoS One2010 Dec 23Hovanessian AGdoi: 10.1371/journal.pone.0015787.
28153390Nucleolin Staining May Aid in the Identification of Circulating Prostate Cancer Cells.Clin Genitourin Cancer2017 JunChalfin HJdoi: 10.1016/j.clgc.2016.12.004
25698539C23 protein meditates bone morphogenetic protein-2-mediated EMT via up-regulation of Erk1/2 and Akt in gastric cancer.Med Oncol2015 MarYang Ydoi: 10.1007/s12032-015-0547-5
26283155Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination.Biomaterials2015 NovFonseca NAdoi: 10.1016/j.biomaterials.2015.08.007
25866190The roles of nucleolin subcellular localization in cancer.Biochimie2015 JunBerger CMdoi: 10.1016/j.biochi.2015.03.023
23763304Overexpression of nucleolin and different expression sites both related to the prognosis of gastric cancer.APMIS2013 OctQiu Wdoi: 10.1111/apm.12131
23610125In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.J Exp Med2013 May 6Pichiorri Fdoi: 10.1084/jem.20120950
25326811Cell surface nucleolin interacts with CXCR4 receptor via the 212 c-terminal portion.Tumour Biol2015 FebNiu Hdoi: 10.1007/s13277-014-2734-y
26846099Prognostic significance of nuclear or cytoplasmic nucleolin expression in human non-small cell lung cancer and its relationship with DNA-PKcs.Tumour Biol2016 AugXu JYdoi: 10.1007/s13277-016-4920-6
27542246Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer.Oncotarget2016 Oct 4Wolfson Edoi: 10.18632/oncotarget.11323.
29650282Meeting the needs of breast cancer: A nucleolin's perspective.Crit Rev Oncol Hematol2018 MayGreg??rio ACdoi: 10.1016/j.critrevonc.2018.03.008
30291252Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway.Nat Commun2018 Oct 5Shin SHdoi: 10.1038/s41467-018-06606-2.
30064438The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68.Mol Cancer2018 Jul 31Wang Xdoi: 10.1186/s12943-018-0860-7.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2231457702Missense_MutationnovelY463C0.25
BLCAchr2231456464Intronnovel0.08
BLCAchr2231461657Missense_MutationNAD166N0.45
BLCAchr2231455915Intronnovel0.52
BLCAchr22314643545'UTRnovel0.5
BLCAchr2231456089Missense_MutationnovelE585K0.55
BRCAchr2231461572Missense_MutationNAD194G0.28
BRCAchr2231456461IntronNA0.44
BRCAchr2231460505Missense_MutationNAP291A0.3
BRCAchr2231463241Missense_MutationnovelE32K0.07
BRCAchr2231456998Splice_Regionnovel0.32
BRCAchr2231461642Missense_Mutationrs769718813E171K0.3
BRCAchr2231460780Missense_MutationnovelE234K0.04RRM_1
BRCAchr2231456053Missense_MutationNAR597W0.58
BRCAchr2231461785Missense_MutationNAG123A0.19
BRCAchr2231456743SilentnovelA531A0.06
BRCAchr2231455261Missense_MutationNAG688E0.16
BRCAchr2231455436Missense_MutationNAG674V0.14
BRCAchr2231461850SilentNAA101A0.03
BRCAchr2231460690Missense_MutationnovelE264K0.35RRM_1
BRCAchr2231460722In_Frame_DelnovelD248_D253del0.2RRM_1
CESCchr2231460415Intronrs7776453860.2
CESCchr22314551553'UTRnovel0.39
CESCchr2231456031Missense_MutationnovelR604Q0.09
CESCchr2231463253Frame_Shift_DelnovelD27Efs*20.25
CESCchr2231458332Missense_Mutationrs779768501E408G0.88
CESCchr2231461666Missense_Mutationrs773553375E163K0.32
CESCchr2231460208Silentrs144610202S328S0.37
CESCchr2231457077Missense_MutationNAE499Q0.4
CESCchr2231457012SilentnovelG520G0.07
COADchr2231461577Silentrs767449678D192D0.32
COADchr2231459053SilentNAV371V0.34
COADchr2231459078Missense_MutationNAA363V0.09
COADchr2231456064Missense_MutationnovelD593G0.32
COADchr2231460734Missense_Mutationrs112363453D249G0.28RRM_1
COADchr2231460865Missense_MutationnovelD205E0.27RRM_1
COADchr22314644115'UTRnovel0.04
COADchr2231458304Silentrs546418951A417A0.14
COADchr2231460416Intronnovel0.1
COADchr2231460552Missense_MutationNAE275V0.17
COADchr2231463255In_Frame_Delrs752943861E26del0.41
COADchr2231455498Silentrs762540059F653F0.31
ESCAchr2231461559Silentrs572420764D198D0.39
ESCAchr2231461850SilentNAA101A0.07
ESCAchr2231463217Missense_Mutationrs375715628D40N0.14
GBMchr2231460528Missense_MutationNAE283G0.38
GBMchr2231456676Missense_MutationnovelR554W0.06
GBMchr2231456086Nonsense_MutationnovelE586*0.29
GBMchr2231455876Intronnovel0.21
GBMchr2231461766SilentNAI129I0.15
GBMchr2231456083Missense_Mutationrs113883398T587A0.34
HNSCchr2231455588SilentnovelA623A0.32
HNSCchr2231460412Intronnovel0.31
HNSCchr2231459067Missense_MutationnovelT367A0.41
HNSCchr2231461557In_Frame_Delrs747203154E193_D198del0.25
KIRCchr2231460227Missense_MutationnovelE322G0.06
KIRCchr2231458359Missense_MutationNAN399S0.38
KIRCchr2231457661Frame_Shift_InsnovelK477Lfs*190.03
KIRCchr2231456647SilentNAS563S0.17
KIRPchr2231460777Missense_MutationnovelD235H0.13RRM_1
LAMLchr2231460836Missense_Mutationrs780724836P215L0.04RRM_1
LGGchr2231460722Missense_MutationnovelD253G0.35RRM_1
LIHCchr2231455511Missense_MutationnovelG649V0.37
LIHCchr2231461634SilentNAA173A0.08
LUADchr2231461702Missense_MutationNAD151N0.63
LUADchr2231461654Missense_MutationNAE167K0.18
LUADchr2231458385SilentnovelR390R0.33
LUADchr2231457727Missense_Mutationrs753488545D455N0.31
LUADchr2231460744Missense_MutationnovelD246Y0.33RRM_1
LUADchr2231457769Missense_MutationnovelD441N0.38
LUADchr2231460277SilentnovelT305T0.11
LUADchr2231457680Missense_MutationnovelN470K0.14
LUSCchr2231456682Missense_Mutationrs758211775A552T0.23
LUSCchr2231461730SilentnovelK141K0.18
LUSCchr2231459000Splice_SitenovelX389_splice0.15
LUSCchr2231461940Missense_MutationnovelK71N0.29
LUSCchr2231460173Missense_MutationnovelD340G0.39
LUSCchr22314551463'UTRnovel0.44
LUSCchr22314551483'UTRnovel0.44
LUSCchr2231457685Missense_MutationNAQ469E0.09
LUSCchr2231460431IntronNA0.26
OVchr2231460850SilentNAA210A0.17
OVchr2231455244SilentnovelR694R0.07
OVchr2231460735Missense_Mutationrs773935750D249N0.05RRM_1
OVchr2231455606SilentNAF617F0.14
OVchr22314551593'UTRnovel0.38
PRADchr2231455510Silentrs763956578G649G0.08
PRADchr2231456744Missense_MutationnovelA531V0.37
READchr2231456031Missense_MutationnovelR604Q0.36
READchr2231460701In_Frame_Delrs746082903E259del0.32RRM_1
READchr2231459053SilentnovelV371V0.36
READchr2231461700SilentNAD151D0.26
SKCMchr2231460276Missense_MutationNAA306T0.38
SKCMchr2231457095Missense_MutationnovelL493F0.25
SKCMchr2231456129SilentNAS571S0.23
SKCMchr2231460669In_Frame_Delrs759848849E267_E271del0.18
SKCMchr2231456129SilentNAS571S0.3
SKCMchr2231456130Missense_Mutationrs756859655S571F0.32
SKCMchr2231456737Silentrs748488201F533F0.13
SKCMchr2231461923Missense_MutationNAP77L0.48
SKCMchr2231462014Missense_Mutationrs202017053V47I0.47
SKCMchr2231460533SilentNAK281K0.1
SKCMchr2231456470Intronnovel0.16
SKCMchr22314551823'UTRnovel0.36
STADchr2231461673SilentNAD160D0.24
STADchr2231460548SilentNAA276A0.34
STADchr2231456124Missense_MutationNAT573N0.29
STADchr2231460843Missense_MutationNAT213S0.07RRM_1
STADchr2231461553Silentrs548571678D200D0.35
STADchr22314551513'UTRnovel0.42
STADchr2231460276Missense_MutationNAA306T0.24
STADchr2231460499Missense_MutationNAA293T0.07
STADchr2231463282Missense_MutationNAA18D0.07
UCECchr2231460411IntronNA0.32
UCECchr2231461558Missense_MutationnovelD199N0.08RRM_1
UCECchr2231460730Missense_MutationNAD250E0.43RRM_1
UCECchr2231457720Missense_MutationnovelR457Q0.38
UCECchr2231456737Silentrs748488201F533F0.29
UCECchr2231457061Missense_MutationNAE504A0.42
UCECchr2231458347Missense_Mutationrs142358440K403R0.37
UCECchr2231460823Missense_MutationnovelK219N0.15RRM_1
UCECchr2231455241Nonsense_MutationnovelG695*0.07
UCECchr2231461553Silentrs548571678D200D0.04
UCECchr2231455887Intronrs7716320060.49
UCECchr2231456708Missense_MutationnovelC543Y0.56
UCECchr2231460267Missense_MutationNAL309I0.2
UCECchr2231458296Missense_MutationnovelR420I0.06
UCECchr2231457669Missense_MutationnovelR474I0.08
UCECchr2231460488SilentnovelQ296Q0.04
UCECchr2231460790Missense_MutationnovelK230N0.11RRM_1
UCECchr2231455473Missense_Mutationrs374715861G662S0.42
UCECchr2231456722Missense_MutationnovelE538D0.52
UCECchr2231455884Intronrs2008308990.4
UCECchr2231460283Silentrs149517418P303P0.28
UCECchr2231461559Silentrs572420764D198D0.37
UCECchr2231460751Missense_MutationnovelE243D0.5RRM_1
UCECchr2231461558Missense_MutationnovelD199N0.43RRM_1
UCECchr2231456736Missense_Mutationrs775008554E534K0.34
UCECchr2231460211Silentrs756879271I327I0.35
UCECchr2231457755SilentnovelT445T0.08
UCECchr2231455871Intronnovel0.21
UCECchr2231455506Missense_Mutationrs201353243G651C0.2
UCECchr2231456122Missense_MutationnovelL574M0.33
UCECchr2231456672Missense_MutationnovelL555R0.29
UCECchr2231456736Missense_Mutationrs775008554E534K0.47
UCECchr2231455564SilentnovelE631E0.05
UCECchr2231460283Silentrs149517418P303P0.04
UCECchr2231460738Missense_Mutationrs767316253D248N0.05RRM_1
UCECchr2231460288Nonsense_MutationnovelE302*0.24
UCECchr2231460563Missense_MutationnovelE271D0.32
UCECchr2231461957Missense_MutationnovelV66I0.07
UCECchr2231455561Silentrs755358839D632D0.39
UCECchr2231457704SilentnovelY462Y0.17
UCECchr2231457017Missense_MutationNAN519D0.42
UCECchr2231460251Missense_MutationnovelL314P0.18
UCECchr2231456719SilentNAA539A0.3
UCECchr2231461972Missense_MutationNAA61S0.23
UCECchr2231455265Nonsense_MutationnovelR687*0.37
UCECchr2231461632Missense_Mutationrs11542689A174V0.43
UCECchr2231461958Silentrs768768923V65V0.46
UCECchr2231455446Missense_MutationnovelG671R0.41
UCECchr2231456745Missense_MutationnovelA531P0.37
UCSchr2231457681Missense_MutationnovelN470T0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.42892.0711e-36
CESCDEL0.36613.4658e-41
HNSCDEL0.21651.278e-25
KIRPDEL0.04175.174e-05
LUSCDEL0.25351.3904e-19
MESODEL0.0920.014499
PAADAMP0.07070.1091
PAADDEL0.02720.2014
TGCTDEL0.06670.062762
THCADEL0.0240.040844
THYMDEL0.03250.10691
UVMDEL0.03750.024639

Survival Analysis
CancerP-value Q-value
THYM0.035

Kaplan-Meier Survival Analysis

KIRC0.013

Kaplan-Meier Survival Analysis

STAD0.028

Kaplan-Meier Survival Analysis

SARC0.031

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

HNSC0.015

Kaplan-Meier Survival Analysis

SKCM0.017

Kaplan-Meier Survival Analysis

KIRP0.00041

Kaplan-Meier Survival Analysis

PAAD0.00046

Kaplan-Meier Survival Analysis

BLCA0.019

Kaplan-Meier Survival Analysis

KICH0.03

Kaplan-Meier Survival Analysis

UCEC0.00047

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LUAD0.0024

Kaplan-Meier Survival Analysis

UVM0.045

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000115053 (Gene tree)
Gene ID
4691
Gene Symbol
NCL
Alias
C23|Nsr1
Full Name
nucleolin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
30,111 bases
Position
chr2:231,453,531-231,483,641
Accession
7667
RBP type
canonical RBP
Summary
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000318195RRM_1PF00076.221.3e-5714
ENSP00000318195RRM_1PF00076.221.3e-5724
ENSP00000318195RRM_1PF00076.221.3e-5734
ENSP00000318195RRM_1PF00076.221.3e-5744
ENSP00000349410RRM_1PF00076.222.3e-4913
ENSP00000349410RRM_1PF00076.222.3e-4923
ENSP00000349410RRM_1PF00076.222.3e-4933
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21118128Post-transcriptional and post-translational regulation of Bcl2.Biochem Soc Trans2010 DecWillimott Sdoi: 10.1042/BST0381571.
1478972A novel vesicle-associated protein (VAP-1) in sea urchin eggs containing multiple RNA-binding consensus sequences.J Cell Sci1992 NovBarton NR-
14528909Decreased brain levels of Lupus La protein and increased U5 small ribonucleoprotein-specific 40 kDa protein in fetal Down syndrome.Cell Mol Biol (Noisy-le-grand)2003 JulGulesserian T-
9148924Two RNA-binding domains determine the RNA-binding specificity of nucleolin.J Biol Chem1997 May 16Serin G-
8676391Nucleolin is a sequence-specific RNA-binding protein: characterization of targets on pre-ribosomal RNA.J Mol Biol1996 Jul 5Ghisolfi-Nieto L-
12000845Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins.Nucleic Acids Res2002 May 15Yang C-
11278842Two different combinations of RNA-binding domains determine the RNA binding specificity of nucleolin.J Biol Chem2001 Apr 27Ginisty H-
15371412Nucleolin interacts with telomerase.J Biol Chem2004 Dec 3Khurts S-
12096904Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes.J Mol Biol2002 Jul 12Fouraux MA-
15303970Characterization of Staufen 1 ribonucleoprotein complexes.Biochem J2004 Dec 1Brendel C-
21938743Glycosilated nucleolin as marker for human gliomas.J Cell Biochem2012 FebGalzio Rdoi: 10.1002/jcb.23381.
29363650MicroRNA Profiling of Transgenic Mice with Myocardial Overexpression of Nucleolin.Chin Med J (Engl)2018 Feb 5Lyu QLdoi: 10.4103/0366-6999.223853.
11922599Isolation and proteomic characterization of the major proteins of the nucleolin-binding ribonucleoprotein complexes.Proteomics2001 NovYanagida M-
9311984RNA recognition by the joint action of two nucleolin RNA-binding domains: genetic analysis and structural modeling.EMBO J1997 Sep 1Bouvet P-
8915542Localization of nucleolin binding sites on human and mouse pre-ribosomal RNA.Biochimie1996Serin G-
16537600Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon.J Virol2006 AprShimakami T-
11118222Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin.EMBO J2000 Dec 15Allain FH-
11023788Solution structure of the two N-terminal RNA-binding domains of nucleolin and NMR study of the interaction with its RNA target.J Mol Biol2000 Oct 20Allain FH-
15170331Contributions of the RNA-binding and linker domains and RNA structure to the specificity and affinity of the nucleolin RBD12/NRE interaction.Biochemistry2004 Jun 8Finger LD-
16782553The role of cytokine mRNA stability in the pathogenesis of autoimmune disease.Autoimmun Rev2006 MaySeko Y-
19332556A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4.Mol Cell Biol2009 JunTurner AJdoi: 10.1128/MCB.00029-09
28090421RNA G-quadruplexes and their potential regulatory roles in translation.Translation (Austin)2016 Oct 4Song Jdoi: 10.1080/21690731.2016.1244031
289792073-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells.Front Pharmacol2017 Sep 20Tao Bdoi: 10.3389/fphar.2017.00657
30257240Long Non-Coding RNA CYP4B1-PS1-001 Inhibits Proliferation and Fibrosis in Diabetic Nephropathy by Interacting with Nucleolin.Cell Physiol Biochem2018Wang Sdoi: 10.1159/000493821
2468131Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.Nucleic Acids Res1989 Mar 25Chan EK-
8341595A protein containing conserved RNA-recognition motifs is associated with ribosomal subunits in Saccharomyces cerevisiae.Nucleic Acids Res1993 Jul 11Ripmaster TL-
8253214Evolutionary clustering and functional similarity of RNA-binding proteins.FEBS Lett1993 Dec 6Fukami-Kobayashi K-
7993898Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.Biochemistry1994 Dec 13Jordan P-
7698229The murine nucleolin protein is an inducible DNA and ATP binding protein which is readily detected in nuclear extracts of lipopolysaccharide-treated splenocytes.Exp Cell Res1995 AprMiranda GA-
11376843Nucleolin stimulates viral internal ribosome entry site-mediated translation.Virus Res2001 JulIzumi RE-
18292223Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin.Proc Natl Acad Sci U S A2008 Mar 4Padilla PIdoi: 10.1073/pnas.0712387105
22675465Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.PLoS One2012Indig FEdoi: 10.1371/journal.pone.0035229
22433872Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.J Biol Chem2012 May 11Chen Jdoi: 10.1074/jbc.M112.349274
22103682Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination.FEBS J2012 FebBhatt Pdoi: 10.1111/j.1742-4658.2011.08430.x
20571027Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1).J Biol Chem2010 Aug 27Ishimaru Ddoi: 10.1074/jbc.M109.098830
24344309Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription.Proc Natl Acad Sci U S A2014 Jan 7Chen YLdoi: 10.1073/pnas.1321800111
28690315Targeting nucleolin for better survival in diffuse large B-cell lymphoma.Leukemia2018 MarJain Ndoi: 10.1038/leu.2017.215
10544174Molecular dissection of nucleolin's role in growth and cell proliferation: new insights.FASEB J1999 NovSrivastava M-
9988723Parathyroid hormone-related protein interacts with RNA.J Biol Chem1999 Feb 19Aarts MM-
9918513Nucleolin: a multifunctional major nucleolar phosphoprotein.Crit Rev Biochem Mol Biol1998Tuteja R-
9880328Association of nonribosomal nucleolar proteins in ribonucleoprotein complexes during interphase and mitosis.Mol Biol Cell1999 JanPinol-Roma S-
3137346Structure of the mouse nucleolin gene. The complete sequence reveals that each RNA binding domain is encoded by two independent exons.J Mol Biol1988 Apr 20Bourbon HM-
9786934A specific isoform of hnRNP D interacts with DNA in the LR1 heterodimer: canonical RNA binding motifs in a sequence-specific duplex DNA binding protein.J Biol Chem1998 Oct 30Dempsey LA-
2440879RNA binding fragments from nucleolin contain the ribonucleoprotein consensus sequence.J Biol Chem1987 Aug 15Bugler B-
1644811Yeast NSR1 protein that has structural similarity to mammalian nucleolin is involved in pre-rRNA processing.J Biol Chem1992 Aug 15Kondo K-
9668083Nucleolin interacts with several ribosomal proteins through its RGG domain.J Biol Chem1998 Jul 24Bouvet P-
1425660Concerted activities of the RNA recognition and the glycine-rich C-terminal domains of nucleolin are required for efficient complex formation with pre-ribosomal RNA.Eur J Biochem1992 Oct 15Ghisolfi L-
9521840Subcellular distribution of distinct nucleolin subfractions recognized by two monoclonal antibodies.Exp Cell Res1998 Mar 15Schwab MS-
9482744Nucleolin functions in the first step of ribosomal RNA processing.EMBO J1998 Mar 2Ginisty H-
9151450NopA64, a novel nucleolar phosphoprotein from proliferating onion cells, sharing immunological determinants with mammalian nucleolin.Planta1997de Carcer G-
8408305Protein localization to the nucleolus: a search for targeting domains in nucleolin.J Cell Sci1993 JulSchmidt-Zachmann MS-
8167407Determination of the functional domains involved in nucleolar targeting of nucleolin.Mol Biol Cell1993 DecCreancier L-
10336496High affinity interactions of nucleolin with G-G-paired rDNA.J Biol Chem1999 May 28Hanakahi LA-
7894017Three types of nuclear genes encoding chloroplast RNA-binding proteins (cp29, cp31 and cp33) are present in Arabidopsis thaliana: presence of cp31 in chloroplasts and its homologue in nuclei/cytoplasms.Plant Mol Biol1995 FebOhta M-
7718615Purification and partial amino acid sequencing of a fructosyllysine-specific binding protein from cell membranes of the monocyte-like cell line U937.Biochim Biophys Acta1995 Apr 6Krantz S-
12707784Deletion and site-specific mutagenesis of nucleolin's carboxy GAR domain.Chromosoma2003 AprPellar GJ-
16508016A nucleolin-binding 3' untranslated region element stabilizes beta-globin mRNA in vivo.Mol Cell Biol2006 MarJiang Y-
11809845Two splice variants of Nopp140 in Drosophila melanogaster.Mol Biol Cell2002 JanWaggener JM-
11397095Recognition of pre-formed and flexible elements of an RNA stem-loop by nucleolin.J Mol Biol2001 Jun 8Bouvet P-
11162447Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle.Biochem Biophys Res Commun2000 Dec 29Ceman S-
11112338The cell-surface-expressed nucleolin is associated with the actin cytoskeleton.Exp Cell Res2000 Dec 15Hovanessian AG-
11112535The C-terminal domain of nucleolin accelerates nucleic acid annealing.Biochemistry2000 Dec 19Hanakahi LA-
10817758Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation.Genes Dev2000 May 15Chen CY-
15823039Nucleolin undergoes partial N- and O-glycosylations in the extranuclear cell compartment.Biochemistry2005 Apr 19Carpentier M-
16837461Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia.J Biol Chem2006 Sep 8Fahling M-
15240685Nucleolin is a second component of the CD154 mRNA stability complex that regulates mRNA turnover in activated T cells.J Immunol2004 Jul 15Singh K-
15033352Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target.J Mol Biol2004 Apr 2Johansson C-
14978336Nucleolin and the packaging signal, psi, promote the budding of human immunodeficiency virus type-1 (HIV-1).Microbiol Immunol2004Ueno T-
14602904Solution structures of stem-loop RNAs that bind to the two N-terminal RNA-binding domains of nucleolin.Nucleic Acids Res2003 Nov 15Finger LD-
19861225Nucleolin/Nsr1p binds to the 3' noncoding region of the tombusvirus RNA and inhibits replication.Virology2010 Jan 5Jiang Ydoi: 10.1016/j.virol.2009.10.007
19671677Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.Mol Cancer Res2009 AugIshimaru Ddoi: 10.1158/1541-7786.MCR-08-0476
18637790Conditional knockout of nucleolin in DT40 cells reveals the functional redundancy of its RNA-binding domains.Biol Cell2009 MarStorck Sdoi: 10.1042/BC20080054.
17846120SBP2 binding affinity is a major determinant in differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay.Mol Cell Biol2007 NovSquires JE-
22617883RNA-binding protein nucleolin in disease.RNA Biol2012 JunAbdelmohsen Kdoi: 10.4161/rna.19718
21917750AU-rich RNA binding proteins in hematopoiesis and leukemogenesis.Blood2011 Nov 24Baou Mdoi: 10.1182/blood-2011-07-347237
21859890Competitive regulation of nucleolin expression by HuR and miR-494.Mol Cell Biol2011 OctTominaga Kdoi: 10.1128/MCB.05955-11
21575138N-Glycosylation influences the structure and self-association abilities of recombinant nucleolin.FEBS J2011 JulLosfeld MEdoi: 10.1111/j.1742-4658.2011.08180.x
21151833Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.Transcription2010 NovHawkins PG-
21081503RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.J Biol Chem2011 Jan 21Guderian Gdoi: 10.1074/jbc.M110.148486
20932061The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity.Biochemistry2010 Nov 16Gonzalez Vdoi: 10.1021/bi100509s
25157258Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors.Front Plant Sci2014 Aug 11Sasvari Zdoi: 10.3389/fpls.2014.00383
24690621Tandem immunoprecipitation approach to identify HIV-1 Gag associated host factors.J Virol Methods2014 JulGao Wdoi: 10.1016/j.jviromet.2014.03.017
27711134Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression.PLoS One2016 Oct 6Kumar Ddoi: 10.1371/journal.pone.0164146
23599269Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex.Blood2013 Jun 6Wise JFdoi: 10.1182/blood-2012-12-471094
28315324Nucleolin protects macrophages from oxLDL-induced foam cell formation through up-regulating ABCA1 expression.Biochem Biophys Res Commun2017 Apr 29Li Ydoi: 10.1016/j.bbrc.2017.03.047
27477284Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.Cell Rep2016 Aug 9Perry RBdoi: 10.1016/j.celrep.2016.07.005
28512205Phorbol-12-myristate-13-acetate-mediated stabilization of leukemia inhibitory factor (lif) mRNA: involvement of Nucleolin and PCBP1.Biochem J2017 Jul 3Chakraborty Adoi: 10.1042/BCJ20170051.
28754881-----
28969051Sp110 enhances macrophage resistance to Mycobacterium tuberculosis via inducing endoplasmic reticulum stress and inhibiting anti-apoptotic factors.Oncotarget2017 Jul 17Wu Ydoi: 10.18632/oncotarget.19300
29168431Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response.RNA Biol2018 Feb 1Zhang Xdoi: 10.1080/15476286.2017.1408764
29567716Locally translated mTOR controls axonal local translation in nerve injury.Science2018 Mar 23Terenzio Mdoi: 10.1126/science.aan1053.
29943658Nucleolin modulates compartmentalization and dynamics of histone 2B-ECFP in the nucleolus.Nucleus2018Sen Gupta Adoi: 10.1080/19491034.2018.1471936
30943371SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex.Biochem Cell Biol2019 Apr 3Gomez GNdoi: 10.1139/bcb-2018-0394
31075282Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's disease (HD) and spinocerebellar ataxia (SCAs).Biochimie2019 AugKhan Edoi: 10.1016/j.biochi.2019.05.001
31182601Shear stress regulation of miR-93 and miR-484 maturation through nucleolin.Proc Natl Acad Sci U S A2019 Jun 25Gongol Bdoi: 10.1073/pnas.1902844116
29930005Diabetes Mellitus-Induced Long Noncoding RNA Dnm3os Regulates Macrophage Functions and Inflammation via Nuclear Mechanisms.Arterioscler Thromb Vasc Biol2018 AugDas Sdoi: 10.1161/ATVBAHA.117.310663.
26512942Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.Brain Pathol2016 SepHernandez-Ortega Kdoi: 10.1111/bpa.12335
29328377Feature genes in metastatic breast cancer identified by MetaDE and SVM classifier methods.Mol Med Rep2018 MarTuo Ydoi: 10.3892/mmr.2018.8398
14585813Expression of nucleolar-related proteins in porcine preimplantation embryos produced in vivo and in vitro.Biol Reprod2004 AprBjerregaard B-
12658636Nucleolar proteins and ultrastructure in bovine in vivo developed, in vitro produced, and parthenogenetic cleavage-stage embryos.Mol Reprod Dev2003 MayLaurincik J-
11319160Immunolocalization of nucleolar proteins during bovine oocyte growth, meiotic maturation, and fertilization.Biol Reprod2001 MayFair T-
6311246Interaction of nucleolar phosphoprotein C23 with cloned segments of rat ribosomal deoxyribonucleic acid.Biochemistry1983 Jul 5Olson MO-
2914325Major nucleolar proteins shuttle between nucleus and cytoplasm.Cell1989 Feb 10Borer RA-
1737751The glycine-rich domain of nucleolin has an unusual supersecondary structure responsible for its RNA-helix-destabilizing properties.J Biol Chem1992 Feb 15Ghisolfi L-
9649628hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.Nucleic Acids Res1998 Jul 15Rajagopalan LE-
8473316Mutagenic analysis of AMP nucleosidase from Escherichia coli. Deletion of a region similar to AMP deaminase and peptide characterization by mass spectrometry.J Biol Chem1993 Apr 25Kvalnes-Krick K-
7789533Phosphorothioate oligonucleotides bind in a non sequence-specific manner to the nucleolar protein C23/nucleolin.FEBS Lett1995 Jun 12Weidner DA-
12565890Centaurin-alpha 1 associates in vitro and in vivo with nucleolin.Biochem Biophys Res Commun2003 Feb 7Dubois T-
11891919Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from granulosa cells.Mol Reprod Dev2002 AprLaurincik J-
11900641Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from embryonic cells.Cloning2001Hyttel P-
11504875N(omega)-arginine dimethylation modulates the interaction between a Gly/Arg-rich peptide from human nucleolin and nucleic acids.Nucleic Acids Res2001 Aug 15Raman B-
11090457Nucleolar proteins and ultrastructure in preimplantation porcine embryos developed in vivo.Biol Reprod2000 DecHyttel P-
10998317Nucleolin as the earliest target molecule of autoantibodies produced in MRL/lpr lupus-prone mice.Clin Immunol2000 OctHirata D-
10930464Initiation of nucleolar assembly is independent of RNA polymerase I transcription.Mol Biol Cell2000 AugDousset T-
10760958Recognition and binding of the human selenocysteine insertion sequence by nucleolin.J Cell Biochem2000 AprWu R-
10727273Nucleolar proteins and nuclear ultrastructure in preimplantation bovine embryos produced in vitro.Biol Reprod2000 AprLaurincik J-
16226712Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.Biochem Biophys Res Commun2005 Dec 2Niture SK-
16153722Role of nucleolin in posttranscriptional control of MMP-9 expression.Biochim Biophys Acta2005 Oct 15Fahling M-
15745627Meiosis and embryo technology: renaissance of the nucleolus.Reprod Fertil Dev2005Maddox-Hyttel P-
15721278Inhibition of NF-kappaB stabilizes gadd45alpha mRNA.Biochem Biophys Res Commun2005 Apr 1Zheng X-
15112326Nucleolar ultrastructure and protein allocation in in vitro produced porcine embryos.Mol Reprod Dev2004 JulLaurincik J-
16777843Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription.Hum Mol Genet2006 Jul 15Becherel OJ-
20147409Relocalization of upstream binding factor to viral replication compartments is UL24 independent and follows the onset of herpes simplex virus 1 DNA synthesis.J Virol2010 MayLymberopoulos MHdoi: 10.1128/JVI.02437-09
22847428CAG expansion induces nucleolar stress in polyglutamine diseases.Proc Natl Acad Sci U S A2012 Aug 14Tsoi Hdoi: 10.1073/pnas.1204089109
17466364Ribosomal RNA and nucleolar proteins from the oocyte are to some degree used for embryonic nucleolar formation in cattle and pig.Theriogenology2007 Sep 1Maddox-Hyttel P-
17320986Translational regulation of PGHS-1 mRNA: 5' untranslated region and first two exons conferring negative regulation.Biochim Biophys Acta2007 FebBunimov N-
17176556Nucleolar remodeling in nuclear transfer embryos.Adv Exp Med Biol2007Laurincik J-
22354986Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.Mol Cell Biol2012 AprPerez-Leal Odoi: 10.1128/MCB.06444-11
21474449Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal.J Biol Chem2011 Jun 17Fujiwara Ydoi: 10.1074/jbc.M110.174680
20926686Hepatocyte growth factor inhibits apoptosis by the profibrotic factor angiotensin II via extracellular signal-regulated kinase 1/2 in endothelial cells and tissue explants.Mol Biol Cell2010 DecLee YHdoi: 10.1091/mbc.E10-04-0341
20406888Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells.J Cell Sci2010 May 15Lee YHdoi: 10.1242/jcs.063545
23471483Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation but increases translation of CSF-1 mRNA.Mol Cell Proteomics2013 JunWoo HHdoi: 10.1074/mcp.M112.025288
26707270Nucleolin promotes in vitro translation of feline calicivirus genomic RNA.Virology2016 FebHernandez BAdoi: 10.1016/j.virol.2015.12.001
29928487Nucleolin facilitates nuclear retention of an ultraconserved region containing TRA2β4 and accelerates colon cancer cell growth.Oncotarget2018 Jun 1Satake Ydoi: 10.18632/oncotarget.25510
29937225A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity.Cell2018 Jul 12Percharde Mdoi: 10.1016/j.cell.2018.05.043
30462330Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication.Nucleic Acids Res2019 Jan 10Bian WXdoi: 10.1093/nar/gky1177.
30501034In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules.Molecules2018 Nov 29Prado Martins Rdoi: 10.3390/molecules23123124.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000322723NCL-2014034-ENSP00000318195710 (aa)-P19338
ENST00000484328NCL-209369--- (aa)--
ENST00000461347NCL-2073967--- (aa)--
ENST00000494618NCL-210910--- (aa)--
ENST00000417652NCL-203568-ENSP00000392747166 (aa)-C9J1H7
ENST00000466274NCL-208671--- (aa)--
ENST00000454824NCL-206606-ENSP00000401620170 (aa)-C9JWL1
ENST00000453992NCL-205964-ENSP00000413775151 (aa)-C9JLB1
ENST00000436894NCL-204562-ENSP00000401322141 (aa)-C9JYW2
ENST00000356936NCL-202890-ENSP00000349410296 (aa)-H7BY16
Gene Model
Click here to download ENSG00000115053's gene model file
Pathways
Pathway IDPathway NameSource
hsa05130Pathogenic Escherichia coli infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000115053Carcinoma, Non-Small-Cell Lung3.2770000E-005-
ENSG00000115053Hearing Loss5E-726121033
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000115053rs168280742231454043?Attention deficit hyperactivity disorder23728934EFO_0003888
ENSG00000115053rs129961542231460981CCommon carotid intima-media thickness in HIV negative individuals29206233[NR] unit increase0.02793EFO_0004860
ENSG00000115053rs75987592231457245?Noise-induced hearing loss26121033[NR]12.75EFO_1001254
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115053's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000115053NCL9030.952ENSG00000151923TIAL19033.613
ENSG00000115053NCL9031.325ENSG00000116001TIA18831.343
ENSG00000115053NCL8530.000ENSG00000101104PABPC1L5730.000
ENSG00000115053NCL9133.333ENSG00000070756PABPC19531.132
ENSG00000115053NCL5743.299ENSG00000099622CIRBP9145.205
ENSG00000115053NCL8930.682ENSG00000090621PABPC49430.556
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000115053NCL10090.541ENSAMEG00000016289NCL6293.679Ailuropoda_melanoleuca
ENSG00000115053NCL8888.710ENSANAG00000024378-8587.879Aotus_nancymaae
ENSG00000115053NCL10095.798ENSANAG00000035814-10095.798Aotus_nancymaae
ENSG00000115053NCL8992.157ENSBTAG00000051320-8190.141Bos_taurus
ENSG00000115053NCL9684.507ENSBTAG00000026909-9592.642Bos_taurus
ENSG00000115053NCL10089.865ENSBTAG00000016174NCL6492.152Bos_taurus
ENSG00000115053NCL8986.508ENSBTAG00000050728-8990.164Bos_taurus
ENSG00000115053NCL10091.892ENSCJAG00000013538NCL9291.020Callithrix_jacchus
ENSG00000115053NCL10090.934ENSCAFG00000011037NCL9290.076Canis_familiaris
ENSG00000115053NCL10091.216ENSCAFG00020023145NCL8790.034Canis_lupus_dingo
ENSG00000115053NCL10089.865ENSCHIG00000010894-7692.857Capra_hircus
ENSG00000115053NCL9380.364ENSCHIG00000026149-6384.340Capra_hircus
ENSG00000115053NCL10088.851ENSCHIG00000021052-9496.503Capra_hircus
ENSG00000115053NCL9871.636ENSCHIG00000012143-8478.005Capra_hircus
ENSG00000115053NCL9075.900ENSTSYG00000036886-9168.356Carlito_syrichta
ENSG00000115053NCL10090.203ENSTSYG00000004355-9289.771Carlito_syrichta
ENSG00000115053NCL9586.806ENSTSYG00000029779-9886.919Carlito_syrichta
ENSG00000115053NCL10089.189ENSCAPG00000009405NCL9178.528Cavia_aperea
ENSG00000115053NCL10089.189ENSCPOG00000001034NCL9278.636Cavia_porcellus
ENSG00000115053NCL10096.454ENSCCAG00000021040-9292.638Cebus_capucinus
ENSG00000115053NCL8789.447ENSCCAG00000000551-8189.552Cebus_capucinus
ENSG00000115053NCL10098.734ENSCATG00000037033NCL10098.734Cercocebus_atys
ENSG00000115053NCL10089.189ENSCLAG00000013080NCL9283.587Chinchilla_lanigera
ENSG00000115053NCL10091.554ENSCSAG00000006660NCL9599.773Chlorocebus_sabaeus
ENSG00000115053NCL9875.172ENSCHOG00000012860NCL8874.773Choloepus_hoffmanni
ENSG00000115053NCL10086.486ENSCANG00000036756NCL94100.000Colobus_angolensis_palliatus
ENSG00000115053NCL9473.835ENSCGRG00001022350-9567.071Cricetulus_griseus_chok1gshd
ENSG00000115053NCL8992.063ENSCGRG00001024315-9181.583Cricetulus_griseus_chok1gshd
ENSG00000115053NCL9384.000ENSCGRG00000017894-8881.566Cricetulus_griseus_crigri
ENSG00000115053NCL9781.588ENSDNOG00000046347-9972.129Dasypus_novemcinctus
ENSG00000115053NCL9387.365ENSDNOG00000010783-9285.496Dasypus_novemcinctus
ENSG00000115053NCL9974.545ENSDORG00000012513-9178.034Dipodomys_ordii
ENSG00000115053NCL9182.946ENSDORG00000023596-9269.444Dipodomys_ordii
ENSG00000115053NCL9884.982ENSETEG00000014756-8690.501Echinops_telfairi
ENSG00000115053NCL9064.906ENSETEG00000008139-6766.062Echinops_telfairi
ENSG00000115053NCL9685.091ENSETEG00000018937-8581.743Echinops_telfairi
ENSG00000115053NCL9060.300ENSETEG00000008553-8862.077Echinops_telfairi
ENSG00000115053NCL10090.203ENSEASG00005008488NCL8897.267Equus_asinus_asinus
ENSG00000115053NCL10090.203ENSECAG00000021868NCL6292.308Equus_caballus
ENSG00000115053NCL9383.273ENSEEUG00000005913NCL8580.528Erinaceus_europaeus
ENSG00000115053NCL10091.226ENSFCAG00000027622NCL9289.482Felis_catus
ENSG00000115053NCL10089.527ENSFDAG00000014291NCL6291.403Fukomys_damarensis
ENSG00000115053NCL10099.338ENSGGOG00000004300NCL100100.000Gorilla_gorilla
ENSG00000115053NCL8275.820ENSHGLG00000005133-9374.825Heterocephalus_glaber_female
ENSG00000115053NCL9083.835ENSHGLG00000011069-6280.995Heterocephalus_glaber_female
ENSG00000115053NCL10089.527ENSHGLG00000002031-9285.605Heterocephalus_glaber_female
ENSG00000115053NCL10089.189ENSHGLG00100014537-10086.255Heterocephalus_glaber_male
ENSG00000115053NCL9082.707ENSHGLG00100000745-8582.368Heterocephalus_glaber_male
ENSG00000115053NCL8988.095ENSJJAG00000016165Ncl9379.726Jaculus_jaculus
ENSG00000115053NCL8984.921ENSLAFG00000013061NCL8583.803Loxodonta_africana
ENSG00000115053NCL10098.734ENSMFAG00000040385NCL10098.734Macaca_fascicularis
ENSG00000115053NCL10098.734ENSMMUG00000018094NCL99100.000Macaca_mulatta
ENSG00000115053NCL10098.013ENSMNEG00000023839NCL99100.000Macaca_nemestrina
ENSG00000115053NCL10098.875ENSMLEG00000028935NCL10098.875Mandrillus_leucophaeus
ENSG00000115053NCL10090.730ENSMICG00000002538-9289.724Microcebus_murinus
ENSG00000115053NCL9776.307ENSMICG00000029975-8682.979Microcebus_murinus
ENSG00000115053NCL9780.137MGP_CAROLIEiJ_G0014362Ncl6183.447Mus_caroli
ENSG00000115053NCL9780.137ENSMUSG00000026234Ncl6183.220Mus_musculus
ENSG00000115053NCL9380.000MGP_PahariEiJ_G0027599Ncl6182.766Mus_pahari
ENSG00000115053NCL9781.507MGP_SPRETEiJ_G0015164Ncl6182.993Mus_spretus
ENSG00000115053NCL6977.966ENSMPUG00000004834-8397.872Mustela_putorius_furo
ENSG00000115053NCL10090.541ENSMLUG00000014547NCL6295.238Myotis_lucifugus
ENSG00000115053NCL9385.091ENSNGAG00000002454-6185.294Nannospalax_galili
ENSG00000115053NCL8377.778ENSNGAG00000006188-5472.559Nannospalax_galili
ENSG00000115053NCL8586.789ENSNLEG00000014107-9586.949Nomascus_leucogenys
ENSG00000115053NCL10066.265ENSODEG00000007803-9063.978Octodon_degus
ENSG00000115053NCL9885.714ENSODEG00000002748-6584.127Octodon_degus
ENSG00000115053NCL9880.000ENSODEG00000002441-8485.593Octodon_degus
ENSG00000115053NCL9584.342ENSODEG00000003281-9181.250Octodon_degus
ENSG00000115053NCL9686.909ENSOCUG00000004312NCL5286.909Oryctolagus_cuniculus
ENSG00000115053NCL10089.527ENSOGAG00000027852NCL5489.527Otolemur_garnettii
ENSG00000115053NCL9387.770ENSOARG00000020709-6589.640Ovis_aries
ENSG00000115053NCL8885.567ENSOARG00000013270-10090.110Ovis_aries
ENSG00000115053NCL9887.179ENSOARG00000013710-7388.435Ovis_aries
ENSG00000115053NCL9872.894ENSOARG00000004072-7176.871Ovis_aries
ENSG00000115053NCL10099.437ENSPPAG00000011619NCL10099.437Pan_paniscus
ENSG00000115053NCL10090.934ENSPPRG00000012603NCL9289.313Panthera_pardus
ENSG00000115053NCL10090.878ENSPTIG00000010393NCL9189.060Panthera_tigris_altaica
ENSG00000115053NCL10099.578ENSPTRG00000013025NCL10099.578Pan_troglodytes
ENSG00000115053NCL10098.734ENSPANG00000010292NCL10098.734Papio_anubis
ENSG00000115053NCL7553.704ENSPMGG00000001785-7353.704Periophthalmus_magnuspinnatus
ENSG00000115053NCL10099.291ENSPPYG00000013265NCL9291.311Pongo_abelii
ENSG00000115053NCL9885.348ENSPCOG00000004160-8689.947Propithecus_coquereli
ENSG00000115053NCL10090.203ENSPCOG00000003051-9189.587Propithecus_coquereli
ENSG00000115053NCL10090.541ENSPVAG00000000297NCL6192.063Pteropus_vampyrus
ENSG00000115053NCL9383.273ENSRNOG00000018273Ncl6185.714Rattus_norvegicus
ENSG00000115053NCL10092.837ENSRBIG00000037525-6397.052Rhinopithecus_bieti
ENSG00000115053NCL10091.216ENSRBIG00000035396-8699.077Rhinopithecus_bieti
ENSG00000115053NCL10097.351ENSRROG00000036103-9996.580Rhinopithecus_roxellana
ENSG00000115053NCL10098.031ENSRROG00000028756-10098.031Rhinopithecus_roxellana
ENSG00000115053NCL10084.972ENSSBOG00000027549-9490.888Saimiri_boliviensis_boliviensis
ENSG00000115053NCL9978.523ENSSBOG00000023094-7675.566Saimiri_boliviensis_boliviensis
ENSG00000115053NCL10096.454ENSSBOG00000029193-9294.640Saimiri_boliviensis_boliviensis
ENSG00000115053NCL10089.865ENSSSCG00000016275NCL9285.135Sus_scrofa
ENSG00000115053NCL9477.338ENSTBEG00000002469-6682.286Tupaia_belangeri
ENSG00000115053NCL10075.676ENSTBEG00000001546-8580.363Tupaia_belangeri
ENSG00000115053NCL10088.851ENSTTRG00000009094NCL9188.172Tursiops_truncatus
ENSG00000115053NCL10090.541ENSUAMG00000005639NCL10093.638Ursus_americanus
ENSG00000115053NCL10090.541ENSUMAG00000015789NCL9288.974Ursus_maritimus
ENSG00000115053NCL9386.192ENSVPAG00000001796NCL6988.732Vicugna_pacos
ENSG00000115053NCL10090.541ENSVVUG00000025564NCL6990.438Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001525angiogenesis16403913.IDAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding21873635.IBAFunction
GO:0003723RNA binding8321232.IDAFunction
GO:0005515protein binding12427757.15064750.15161933.15674325.16213212.16403913.16648475.16777843.17615292.17620599.18292223.18457437.19174163.19393617.19515850.19877579.20195357.20221403.20858735.21081503.21242313.21281639.22103682.24515436.24658146.24965446.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus15121898.24071584.IDAComponent
GO:0005654nucleoplasm23353999.IDAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus12944467.19393617.24071584.IDAComponent
GO:0005938cell cortex16403913.IDAComponent
GO:0008022protein C-terminus binding16403913.IPIFunction
GO:0016020membrane19946888.HDAComponent
GO:0017148negative regulation of translation16213212.IMPProcess
GO:0036464cytoplasmic ribonucleoprotein granule15121898.IDAComponent
GO:0042162telomeric DNA binding8321232.IDAFunction
GO:0042802identical protein binding21575138.IPIFunction
GO:0044547DNA topoisomerase binding8567649.IPIFunction
GO:0045944positive regulation of transcription by RNA polymerase II-IEAProcess
GO:0048027mRNA 5'-UTR binding16213212.IDAFunction
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071364cellular response to epidermal growth factor stimulus-IEAProcess
GO:1901838positive regulation of transcription of nucleolar large rRNA by RNA polymerase I24071584.IMPProcess
GO:1990830cellular response to leukemia inhibitory factor-IEAProcess
GO:1990904ribonucleoprotein complex21873635.IBAComponent
GO:1990904ribonucleoprotein complex17289661.18809582.IDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us