EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16575407	Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.	Cell Death Differ	2006 Nov	Lin L	-
26893477	Activation of the MDA-5-IPS-1 Viral Sensing Pathway Induces Cancer Cell Death and Type I IFN-Dependent Antitumor Immunity.	Cancer Res	2016 Apr 15	Yu X	doi: 10.1158/0008-5472.CAN-15-2142
28940253	The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer.	J Pathol	2018 Jan	Shu XS	doi: 10.1002/path.4986
29997212	Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells.	J Virol	2018 Sep 12	Walton RW	doi: 10.1128/JVI.00879-18

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	162317861	Frame_Shift_Del	novel	*R149Kfs12**	0.04
BLCA	chr2	162288279	Missense_Mutation	NA	Q317H	0.27	ResIII
BLCA	chr2	162318295	Frame_Shift_Ins	novel	*Y5Gfs19**	0.27
BLCA	chr2	162310843	Silent	novel	L182L	0.6
BLCA	chr2	162273824	Missense_Mutation	novel	L809F	0.06
BLCA	chr2	162276902	Nonsense_Mutation	novel	E697*	0.39
BLCA	chr2	162280085	Missense_Mutation	rs747683934	I518V	0.73
BLCA	chr2	162280061	Missense_Mutation	rs758807886	D526Y	0.44
BLCA	chr2	162267168	3'UTR	novel		0.96
BLCA	chr2	162280037	Missense_Mutation	novel	E534Q	0.42
BRCA	chr2	162272289	Missense_Mutation	NA	E851D	0.16
BRCA	chr2	162272283	Missense_Mutation	rs376785582	M853I	0.08
BRCA	chr2	162267207	Missense_Mutation	novel	E1024G	0.08
BRCA	chr2	162273932	Missense_Mutation	NA	E773K	0.41
BRCA	chr2	162306848	Missense_Mutation	novel	E210D	0.14
BRCA	chr2	162273818	Missense_Mutation	rs769742165	T811A	0.13
BRCA	chr2	162318187	Missense_Mutation	rs762115082	E41Q	0.13
BRCA	chr2	162282573	Silent	novel	L367L	0.16
CESC	chr2	162268203	Missense_Mutation	NA	K897N	0.36
CESC	chr2	162272312	Missense_Mutation	NA	E844Q	0.15
CESC	chr2	162272294	Nonsense_Mutation	rs750804689	R850*	0.15
CESC	chr2	162277560	Silent	novel	E633E	0.09
CESC	chr2	162280017	Silent	novel	A540A	0.38
COAD	chr2	162277607	Nonsense_Mutation	rs745937740	R618*	0.25
COAD	chr2	162277472	Missense_Mutation	novel	L663V	0.05
COAD	chr2	162288153	Silent	novel	V359V	0.32
COAD	chr2	162277475	Missense_Mutation	novel	D662N	0.49
COAD	chr2	162273936	Missense_Mutation	NA	Q771H	0.14
COAD	chr2	162288280	Missense_Mutation	NA	Q317R	0.44	ResIII
COAD	chr2	162278213	Missense_Mutation	rs777933362	E586G	0.11
COAD	chr2	162280092	Silent	NA	A515A	0.36
COAD	chr2	162272290	Missense_Mutation	novel	E851G	0.13
COAD	chr2	162273914	Missense_Mutation	rs587777448	R779C	0.08
COAD	chr2	162273945	Splice_Site	NA	X769_splice	0.4
COAD	chr2	162268122	Missense_Mutation	NA	E924D	0.11
COAD	chr2	162277621	Missense_Mutation	NA	I613S	0.1
COAD	chr2	162280078	Missense_Mutation	NA	T520N	0.28
COAD	chr2	162277594	Missense_Mutation	rs186942719	A622V	0.26
COAD	chr2	162273914	Missense_Mutation	rs587777448	R779C	0.1
COAD	chr2	162277630	Missense_Mutation	NA	A610V	0.13
COAD	chr2	162272361	Frame_Shift_Ins	novel	*E827Dfs5**	0.04
COAD	chr2	162277623	Silent	NA	Q612Q	0.11
COAD	chr2	162276712	Missense_Mutation	NA	S760I	0.26
COAD	chr2	162293634	Silent	novel	S268S	0.17
DLBC	chr2	162288173	Frame_Shift_Ins	novel	*A353Sfs3**	0.31	ResIII
ESCA	chr2	162278205	Frame_Shift_Ins	rs553669430	*A589Sfs21**	0.43
ESCA	chr2	162272320	Missense_Mutation	novel	I841N	0.07
ESCA	chr2	162276755	Missense_Mutation	NA	E746K	0.29
GBM	chr2	162276796	Missense_Mutation	novel	Y732C	0.27
GBM	chr2	162282372	Missense_Mutation	novel	L434V	0.07	ResIII
GBM	chr2	162317919	Missense_Mutation	novel	L130R	0.13
GBM	chr2	162282551	Missense_Mutation	rs145520044	R374H	0.5	ResIII
HNSC	chr2	162276908	Nonsense_Mutation	novel	E695*	0.24
HNSC	chr2	162278296	Missense_Mutation	novel	M558I	0.1
HNSC	chr2	162276729	Silent	novel	L754L	0.7
HNSC	chr2	162267168	3'UTR	novel		0.29
HNSC	chr2	162277647	Missense_Mutation	novel	L604F	0.12
HNSC	chr2	162310777	Missense_Mutation	novel	E204Q	0.3
HNSC	chr2	162272243	Missense_Mutation	novel	E867Q	0.23
HNSC	chr2	162306850	Missense_Mutation	novel	E210Q	0.07
HNSC	chr2	162276921	Silent	novel	L690L	0.25
KIRC	chr2	162288174	Missense_Mutation	NA	K352N	0.3	ResIII
KIRP	chr2	162310887	Missense_Mutation	NA	L167P	0.28
LGG	chr2	162268196	Missense_Mutation	novel	P900T	0.32
LGG	chr2	162280047	Silent	rs369245661	N530N	0.42
LGG	chr2	162277546	Missense_Mutation	NA	F638C	0.47
LGG	chr2	162276704	Missense_Mutation	NA	F763V	0.16
LIHC	chr2	162282571	Silent	novel	L367L	0.44
LIHC	chr2	162267554	Silent	novel	V941V	0.45
LUAD	chr2	162318146	Silent	novel	G54G	0.14
LUAD	chr2	162267476	Splice_Region	rs559069227		0.13
LUAD	chr2	162276755	Missense_Mutation	NA	E746K	0.16
LUAD	chr2	162318026	Silent	novel	Y94Y	0.11
LUAD	chr2	162268207	Missense_Mutation	novel	Y896C	0.14
LUAD	chr2	162277634	Missense_Mutation	novel	E609K	0.07
LUAD	chr2	162273913	Missense_Mutation	rs587777446	R779H	0.14
LUAD	chr2	162276934	Missense_Mutation	NA	M686T	0.15
LUAD	chr2	162288243	Silent	novel	L329L	0.29
LUAD	chr2	162276848	Missense_Mutation	NA	T715P	0.29
LUAD	chr2	162272266	Missense_Mutation	novel	H859L	0.2
LUAD	chr2	162268124	Missense_Mutation	NA	E924Q	0.12
LUAD	chr2	162277598	Missense_Mutation	NA	D621H	0.34
LUSC	chr2	162267127	3'UTR	novel		0.3
LUSC	chr2	162288242	Missense_Mutation	rs141848057	P330S	0.28	ResIII
LUSC	chr2	162318169	Nonsense_Mutation	novel	Q47*	0.24
LUSC	chr2	162276845	Nonsense_Mutation	novel	E716*	0.1
LUSC	chr2	162318009	Missense_Mutation	NA	T100M	0.31
LUSC	chr2	162277523	Missense_Mutation	rs556917411	D646N	0.43
LUSC	chr2	162318470	5'UTR	novel		0.33
LUSC	chr2	162318471	5'UTR	novel		0.33
LUSC	chr2	162288279	Missense_Mutation	NA	Q317H	0.51	ResIII
LUSC	chr2	162306828	Missense_Mutation	novel	G217D	0.24
LUSC	chr2	162272312	Missense_Mutation	novel	E844K	0.14
LUSC	chr2	162276877	Missense_Mutation	NA	R705I	0.28
LUSC	chr2	162273875	Missense_Mutation	NA	A792T	0.18
LUSC	chr2	162278237	Missense_Mutation	novel	Y578C	0.27
LUSC	chr2	162318134	Silent	NA	A58A	0.18
LUSC	chr2	162276890	Missense_Mutation	novel	L701V	0.08
LUSC	chr2	162276748	Missense_Mutation	novel	G748V	0.11
LUSC	chr2	162277414	Splice_Site	novel	X682_splice	0.52
LUSC	chr2	162277415	Nonsense_Mutation	novel	E682*	0.52
LUSC	chr2	162273869	Nonsense_Mutation	novel	E794*	0.34
LUSC	chr2	162268244	Missense_Mutation	novel	K884Q	0.39
LUSC	chr2	162282462	Missense_Mutation	rs748544874	V404I	0.12	ResIII
LUSC	chr2	162267276	Missense_Mutation	novel	K1001R	0.32
MESO	chr2	162281454	Missense_Mutation	novel	L466F	0.16	ResIII
OV	chr2	162288179	Missense_Mutation	rs35207787	K351E	0.2	ResIII
OV	chr2	162288260	Missense_Mutation	NA	N324Y	0.13	ResIII
OV	chr2	162318051	Missense_Mutation	novel	T86N	0.1
OV	chr2	162306832	Missense_Mutation	NA	D216H	0.3
PAAD	chr2	162268184	Missense_Mutation	novel	T904A	0.2
PAAD	chr2	162273888	Silent	rs35677292	I787I	0.15
PAAD	chr2	162277666	Missense_Mutation	rs200945986	R598H	0.18
PAAD	chr2	162318169	Nonsense_Mutation	novel	Q47*	0.26
PAAD	chr2	162288317	Missense_Mutation	novel	E305K	0.28
READ	chr2	162281439	Frame_Shift_Del	NA	*L471Qfs32**	0.21	ResIII
READ	chr2	162277652	Missense_Mutation	novel	H603Y	0.19
READ	chr2	162272377	Missense_Mutation	rs376048533	R822Q	0.13
SARC	chr2	162318033	Missense_Mutation	novel	A92D	0.09
SARC	chr2	162280108	Missense_Mutation	novel	C510Y	0.48
SKCM	chr2	162288327	Silent	NA	S301S	0.38
SKCM	chr2	162293637	Silent	novel	V267V	0.27
SKCM	chr2	162277644	Silent	NA	R605R	0.24
SKCM	chr2	162282455	Missense_Mutation	novel	S406F	0.3	ResIII
SKCM	chr2	162276787	Missense_Mutation	NA	S735F	0.26
SKCM	chr2	162282454	Silent	NA	S406S	0.32
SKCM	chr2	162306826	Missense_Mutation	NA	P218S	0.41
SKCM	chr2	162318338	5'UTR	rs775136299		0.48
SKCM	chr2	162268089	Splice_Region	NA	F935F	0.4
SKCM	chr2	162278318	Missense_Mutation	NA	K551I	0.45
SKCM	chr2	162267497	Silent	rs570676307	I960I	0.25
SKCM	chr2	162306772	Missense_Mutation	novel	E236K	0.25
SKCM	chr2	162306773	Silent	novel	K235K	0.25
SKCM	chr2	162278233	Silent	novel	E579E	0.35
SKCM	chr2	162306777	Missense_Mutation	NA	E234G	0.23
SKCM	chr2	162276871	Missense_Mutation	novel	T707I	0.12
SKCM	chr2	162277606	Missense_Mutation	rs200017837	R618Q	0.61
SKCM	chr2	162288189	Silent	NA	L347L	0.16
SKCM	chr2	162272348	Silent	NA	L832L	0.36
SKCM	chr2	162273888	Silent	rs35677292	I787I	0.53
SKCM	chr2	162273888	Silent	rs35677292	I787I	0.39
SKCM	chr2	162273834	Silent	novel	I805I	0.44
SKCM	chr2	162267530	Silent	NA	K949K	0.11
SKCM	chr2	162282516	Missense_Mutation	NA	R386C	0.44	ResIII
SKCM	chr2	162278228	Nonsense_Mutation	NA	W581*	0.24
SKCM	chr2	162280021	Missense_Mutation	NA	F539S	0.34
SKCM	chr2	162282467	Missense_Mutation	novel	E402A	0.42	ResIII
SKCM	chr2	162267132	3'UTR	novel		0.35
SKCM	chr2	162282375	Nonsense_Mutation	novel	Q433*	0.48	ResIII
STAD	chr2	162317914	Silent	NA	R132R	0.06
STAD	chr2	162277555	In_Frame_Del	novel	E633_K634del	0.08
STAD	chr2	162278205	Frame_Shift_Ins	rs553669430	*A589Sfs21**	0.53
STAD	chr2	162277607	Nonsense_Mutation	rs745937740	R618*	0.46
STAD	chr2	162318163	Missense_Mutation	rs747135877	T49A	0.51
STAD	chr2	162282573	Silent	novel	L367L	0.46
STAD	chr2	162278206	Frame_Shift_Del	rs753152979	*A589Lfs16**	0.33
STAD	chr2	162282469	Silent	NA	P401P	0.37
STAD	chr2	162306764	Missense_Mutation	NA	W238C	0.2
STAD	chr2	162276733	Frame_Shift_Del	novel	*A751Vfs2**	0.72
STAD	chr2	162273919	Missense_Mutation	novel	K777R	0.29
STAD	chr2	162267199	3'UTR	novel		0.19
STAD	chr2	162272378	Nonsense_Mutation	rs747926684	R822*	0.22
UCEC	chr2	162277572	Missense_Mutation	novel	F629L	0.29
UCEC	chr2	162310926	Missense_Mutation	rs372069902	A154V	0.31
UCEC	chr2	162288304	Missense_Mutation	novel	R309M	0.06
UCEC	chr2	162272328	Silent	novel	S838S	0.26
UCEC	chr2	162278205	Frame_Shift_Ins	rs553669430	*A589Sfs21**	0.34
UCEC	chr2	162267183	3'UTR	novel		0.25
UCEC	chr2	162310913	Silent	novel	N158N	0.45
UCEC	chr2	162277676	Missense_Mutation	rs191839015	R595C	0.48
UCEC	chr2	162267497	Silent	novel	I960I	0.21
UCEC	chr2	162277660	Missense_Mutation	NA	C600Y	0.27
UCEC	chr2	162278206	Frame_Shift_Del	rs753152979	*A589Lfs16**	0.47
UCEC	chr2	162278206	Frame_Shift_Del	rs753152979	*A589Lfs16**	0.36
UCEC	chr2	162267318	Missense_Mutation	rs767968518	F987S	0.13
UCEC	chr2	162273888	Silent	rs35677292	I787I	0.48
UCEC	chr2	162273914	Missense_Mutation	novel	R779S	0.12
UCEC	chr2	162267533	Missense_Mutation	novel	Q948H	0.5
UCEC	chr2	162277451	Missense_Mutation	rs370203250	D670N	0.2
UCEC	chr2	162310767	Missense_Mutation	novel	A207V	0.24
UCEC	chr2	162281449	Frame_Shift_Del	novel	*N468Tfs11**	0.18	ResIII
UCEC	chr2	162267080	3'UTR	novel		0.43
UCEC	chr2	162278247	Missense_Mutation	rs138057665	T575A	0.33
UCEC	chr2	162317978	Silent	novel	A110A	0.38
UCEC	chr2	162318308	5'UTR	novel		0.7
UCEC	chr2	162278319	Frame_Shift_Ins	novel	*K551Lfs8**	0.09
UCEC	chr2	162277435	Missense_Mutation	novel	F675C	0.53
UCEC	chr2	162310708	Intron	novel		0.26
UCEC	chr2	162267202	Nonstop_Mutation	novel	1026Qext17	0.33
UCEC	chr2	162267130	3'UTR	novel		0.18
UCEC	chr2	162277676	Missense_Mutation	rs191839015	R595C	0.31
UCEC	chr2	162281543	Missense_Mutation	novel	F437V	0.37	ResIII
UCEC	chr2	162267183	3'UTR	novel		0.43
UCEC	chr2	162281449	Frame_Shift_Del	novel	*N468Tfs11**	0.37	ResIII
UCEC	chr2	162277668	Silent	novel	E597E	0.28
UCEC	chr2	162273833	Missense_Mutation	rs144341455	R806C	0.18
UCEC	chr2	162278206	Frame_Shift_Del	rs753152979	*A589Lfs16**	0.38
UCEC	chr2	162317903	Missense_Mutation	novel	L135F	0.17
UCEC	chr2	162267284	Frame_Shift_Del	NA	*K998Nfs7**	0.33
UCEC	chr2	162288169	Missense_Mutation	rs751669754	S354F	0.25	ResIII
UCEC	chr2	162268255	Missense_Mutation	rs771902342	S880I	0.32
UCEC	chr2	162277623	Silent	NA	Q612Q	0.26
UCEC	chr2	162310874	Silent	novel	I171I	0.16
UCEC	chr2	162267480	Missense_Mutation	novel	Q966R	0.19
UCEC	chr2	162267224	Silent	NA	C1018C	0.29
UCEC	chr2	162278206	Frame_Shift_Del	rs753152979	*A589Lfs16**	0.43
UCEC	chr2	162272378	Nonsense_Mutation	rs747926684	R822*	0.23
UCEC	chr2	162317858	Missense_Mutation	novel	N150K	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.031	0.13394
DLBC	DEL	0.1458	0.01124
PAAD	DEL	0.0326	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.005	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.00014	Kaplan-Meier Survival Analysis
MESO	0.0013	Kaplan-Meier Survival Analysis
PRAD	0.046	Kaplan-Meier Survival Analysis
PAAD	0.0034	Kaplan-Meier Survival Analysis
READ	0.046	Kaplan-Meier Survival Analysis
LAML	0.035	Kaplan-Meier Survival Analysis
UCEC	0.025	Kaplan-Meier Survival Analysis
CHOL	0.046	Kaplan-Meier Survival Analysis
LUAD	0.046	Kaplan-Meier Survival Analysis
OV	0.035	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000115267 (Gene tree)
Gene ID: 64135
Gene Symbol: IFIH1
Alias: MDA-5|Hlcd|MDA5|IDDM19
Full Name: interferon induced with helicase C domain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 51,686 bases
Position: chr2:162,267,079-162,318,764
Accession: 18873
RBP type: canonical RBP
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000496816	ResIII	PF04851.15	3.5e-20	1	1
ENSP00000263642	ResIII	PF04851.15	3.7e-20	1	1
ENSP00000497271	ResIII	PF04851.15	3.7e-20	1	1
ENSP00000496816	RIG-I_C-RD	PF11648.8	4.5e-36	1	1
ENSP00000263642	RIG-I_C-RD	PF11648.8	4.8e-36	1	1
ENSP00000497271	RIG-I_C-RD	PF11648.8	4.8e-36	1	1
ENSP00000496816	DEAD	PF00270.29	9.7e-18	1	1
ENSP00000263642	DEAD	PF00270.29	1e-17	1	1
ENSP00000497271	DEAD	PF00270.29	1e-17	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16877044	siRNA and isRNA: two edges of one sword.	Mol Ther	2006 Oct	Schlee M	-
19531363	Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.	Arch Biochem Biophys	2009 Aug 1	Li X	doi: 10.1016/j.abb.2009.06.008
17190814	Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.	Proc Natl Acad Sci U S A	2007 Jan 9	Saito T	-
22301138	Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.	J Virol	2012 Apr	Xing J	doi: 10.1128/JVI.06713-11
25031338	Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5.	J Virol	2014 Oct	Ye C	doi: 10.1128/JVI.01115-14
24109602	Ancient origins of vertebrate-specific innate antiviral immunity.	Mol Biol Evol	2014 Jan	Mukherjee K	doi: 10.1093/molbev/mst184
19380577	Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.	J Biol Chem	2009 Jun 26	Takahasi K	doi: 10.1074/jbc.M109.007179
22314235	MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.	EMBO J	2012 Apr 4	Berke IC	doi: 10.1038/emboj.2012.19
25259935	RIG-I self-oligomerization is either dispensable or very transient for signal transduction.	PLoS One	2014 Sep 26	Louber J	doi: 10.1371/journal.pone.0108770
25127512	The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.	Mol Cell	2014 Sep 4	Bruns AM	doi: 10.1016/j.molcel.2014.07.003
24522921	Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.	J Virol	2014 May	Siu KL	doi: 10.1128/JVI.03649-13
27203181	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.	Mol Cell	2016 May 19	Uchikawa E	doi: 10.1016/j.molcel.2016.04.021.
26215161	Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.	BMC Biol	2015 Jul 28	Louber J	doi: 10.1186/s12915-015-0166-9.
29769346	Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA.	J Virol	2018 Jul 17	Fang P	doi: 10.1128/JVI.00712-18
20456414	Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.	Clin Exp Immunol	2010 Aug	Lenert P	doi: 10.1111/j.1365-2249.2010.04176.x
18562536	Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection.	J Virol	2008 Sep	Daffis S	doi: 10.1128/JVI.00918-08
24474800	Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.	Proc Natl Acad Sci U S A	2014 Jan 28	Wu J	doi: 10.1073/pnas.1316467111
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23846693	DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA.	J Biol Chem	2013 Aug 23	Ordureau A	doi: 10.1074/jbc.M113.479550
16782388	The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines.	Microbes Infect	2006 Jul	Berghall H	-
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Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000263642	IFIH1-201	3595	-	ENSP00000263642	1025 (aa)	-	Q9BYX4
ENST00000648433	IFIH1-204	3234	-	ENSP00000496816	986 (aa)	-	-
ENST00000649979	IFIH1-207	3544	-	ENSP00000497271	1025 (aa)	-	UPI000013D436
ENST00000649554	IFIH1-206	2795	-	-	- (aa)	-	-
ENST00000649426	IFIH1-205	791	-	-	- (aa)	-	-
ENST00000421365	IFIH1-202	1617	-	ENSP00000408450	221 (aa)	-	Q9BYX4
ENST00000464129	IFIH1-203	567	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000115267's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04622	RIG-I-like receptor signaling pathway	KEGG
hsa05161	Hepatitis B	KEGG
hsa05162	Measles	KEGG
hsa05164	Influenza A	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115267	Cholesterol	5.48668531993075E-8	17903299
ENSG00000115267	Cholesterol	3.92045195386449E-8	17903299
ENSG00000115267	Cholesterol	7.47812602937582E-7	17903299
ENSG00000115267	Autoantibodies	2E-14	21829393
ENSG00000115267	Diabetes Mellitus, Type 1	2E-14	21829393
ENSG00000115267	Inflammatory Bowel Diseases	4E-10	26192919
ENSG00000115267	Psoriasis	1E-18	25903422
ENSG00000115267	Diabetes Mellitus, Type 1	2E-11	17554260
ENSG00000115267	Psoriasis	1E-7	25903422
ENSG00000115267	Lupus Erythematosus, Systemic	4E-8	26502338
ENSG00000115267	Psoriasis	3E-11	25903422
ENSG00000115267	Proteins	7E-10	20694011
ENSG00000115267	Psoriasis	1E-8	25903422
ENSG00000115267	Diabetes Mellitus, Type 1	7E-9	19430480

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115267	rs1990760	2	162267541	?	Selective IgA deficiency	27723758	[NR]	1.4285715	EFO_1001929
ENSG00000115267	rs1990760	2	162267541	T	Systemic lupus erythematosus	26502338	[NR]	1.15	EFO_0002690
ENSG00000115267	rs1990760	2	162267541	?	Inflammatory bowel disease	26192919			EFO_0003767
ENSG00000115267	rs1990760	2	162267541	?	Type 1 diabetes	19430480			EFO_0001359
ENSG00000115267	rs35667974	2	162268127	T	Type 1 diabetes	25751624		1.6949153	EFO_0001359
ENSG00000115267	rs72871627	2	162280432	A	Type 1 diabetes	25751624		1.6393442	EFO_0001359
ENSG00000115267	rs1990760	2	162267541	T	Systemic lupus erythematosus	19838195		1.17	EFO_0002690
ENSG00000115267	rs1990760	2	162267541	C	Type 1 diabetes	21829393	[NR]	1.2	EFO_0001359
ENSG00000115267	rs1990760	2	162267541	?	Immunoglobulin A	20694011	[1.32-1.69]	1.49	EFO_0004747
ENSG00000115267	rs1990760	2	162267541	A	Type 1 diabetes	17554260	[1.11-1.23]	1.18	EFO_0001359

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115267's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000115267	IFIH1	70	40.865	ENSG00000108771	DHX58	100	49.080
ENSG00000115267	IFIH1	97	31.115	ENSG00000107201	DDX58	96	34.667

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115267	IFIH1	70	42.382	ENSAPOG00000017013	dhx58	98	42.382	Acanthochromis_polyacanthus
ENSG00000115267	IFIH1	98	48.614	ENSAPOG00000024529	ifih1	97	47.886	Acanthochromis_polyacanthus
ENSG00000115267	IFIH1	71	34.550	ENSAMEG00000003766	DDX58	76	34.550	Ailuropoda_melanoleuca
ENSG00000115267	IFIH1	100	84.144	ENSAMEG00000005698	IFIH1	99	84.144	Ailuropoda_melanoleuca
ENSG00000115267	IFIH1	70	40.222	ENSAMEG00000005941	DHX58	99	40.222	Ailuropoda_melanoleuca
ENSG00000115267	IFIH1	99	48.279	ENSACIG00000021179	ifih1	98	48.134	Amphilophus_citrinellus
ENSG00000115267	IFIH1	70	43.889	ENSACIG00000010643	dhx58	98	43.889	Amphilophus_citrinellus
ENSG00000115267	IFIH1	98	48.024	ENSAOCG00000014773	ifih1	97	47.348	Amphiprion_ocellaris
ENSG00000115267	IFIH1	70	41.828	ENSAOCG00000016713	dhx58	98	41.828	Amphiprion_ocellaris
ENSG00000115267	IFIH1	98	47.925	ENSAPEG00000018872	ifih1	97	47.250	Amphiprion_percula
ENSG00000115267	IFIH1	70	41.551	ENSAPEG00000004817	dhx58	98	41.551	Amphiprion_percula
ENSG00000115267	IFIH1	70	42.105	ENSATEG00000001847	dhx58	98	42.105	Anabas_testudineus
ENSG00000115267	IFIH1	99	46.502	ENSATEG00000018364	ifih1	98	46.351	Anabas_testudineus
ENSG00000115267	IFIH1	75	32.963	ENSAPLG00000015091	DDX58	86	33.042	Anas_platyrhynchos
ENSG00000115267	IFIH1	99	61.538	ENSAPLG00000010913	IFIH1	99	61.441	Anas_platyrhynchos
ENSG00000115267	IFIH1	70	37.772	ENSAPLG00000013187	DHX58	99	37.772	Anas_platyrhynchos
ENSG00000115267	IFIH1	65	34.520	ENSACAG00000001354	DDX58	57	39.338	Anolis_carolinensis
ENSG00000115267	IFIH1	70	43.811	ENSACAG00000012501	DHX58	98	43.794	Anolis_carolinensis
ENSG00000115267	IFIH1	99	58.755	ENSACAG00000014017	IFIH1	99	59.281	Anolis_carolinensis
ENSG00000115267	IFIH1	70	40.865	ENSANAG00000029056	DHX58	99	42.314	Aotus_nancymaae
ENSG00000115267	IFIH1	100	92.976	ENSANAG00000028163	IFIH1	100	92.976	Aotus_nancymaae
ENSG00000115267	IFIH1	70	42.083	ENSACLG00000002574	dhx58	99	42.083	Astatotilapia_calliptera
ENSG00000115267	IFIH1	99	47.512	ENSACLG00000012934	ifih1	98	47.745	Astatotilapia_calliptera
ENSG00000115267	IFIH1	70	42.500	ENSACLG00000002582	dhx58	98	42.500	Astatotilapia_calliptera
ENSG00000115267	IFIH1	69	42.676	ENSAMXG00000030658	dhx58	98	42.228	Astyanax_mexicanus
ENSG00000115267	IFIH1	98	49.245	ENSAMXG00000010023	ifih1	97	49.041	Astyanax_mexicanus
ENSG00000115267	IFIH1	69	40.390	ENSBTAG00000046580	DHX58	98	40.390	Bos_taurus
ENSG00000115267	IFIH1	97	31.748	ENSBTAG00000003366	DDX58	68	35.582	Bos_taurus
ENSG00000115267	IFIH1	99	83.317	ENSBTAG00000008142	IFIH1	99	83.415	Bos_taurus
ENSG00000115267	IFIH1	52	35.749	WBGene00001090	drh-1	70	34.711	Caenorhabditis_elegans
ENSG00000115267	IFIH1	100	92.780	ENSCJAG00000005956	IFIH1	100	92.780	Callithrix_jacchus
ENSG00000115267	IFIH1	70	40.586	ENSCJAG00000014852	DHX58	99	40.586	Callithrix_jacchus
ENSG00000115267	IFIH1	97	31.317	ENSCJAG00000007741	DDX58	98	31.055	Callithrix_jacchus
ENSG00000115267	IFIH1	70	33.826	ENSCAFG00000001807	DDX58	74	33.826	Canis_familiaris
ENSG00000115267	IFIH1	70	41.226	ENSCAFG00000015720	DHX58	98	41.226	Canis_familiaris
ENSG00000115267	IFIH1	99	82.698	ENSCAFG00000010438	IFIH1	99	83.187	Canis_familiaris
ENSG00000115267	IFIH1	99	82.796	ENSCAFG00020004329	IFIH1	99	83.284	Canis_lupus_dingo
ENSG00000115267	IFIH1	70	41.111	ENSCAFG00020013642	DHX58	99	46.721	Canis_lupus_dingo
ENSG00000115267	IFIH1	84	32.269	ENSCAFG00020014567	DDX58	94	31.567	Canis_lupus_dingo
ENSG00000115267	IFIH1	69	40.303	ENSCHIG00000017011	DHX58	98	40.414	Capra_hircus
ENSG00000115267	IFIH1	68	35.142	ENSCHIG00000025883	DDX58	71	35.414	Capra_hircus
ENSG00000115267	IFIH1	99	83.610	ENSCHIG00000019848	IFIH1	99	83.821	Capra_hircus
ENSG00000115267	IFIH1	100	90.341	ENSTSYG00000005900	IFIH1	100	90.341	Carlito_syrichta
ENSG00000115267	IFIH1	97	31.707	ENSTSYG00000004200	DDX58	98	31.902	Carlito_syrichta
ENSG00000115267	IFIH1	83	79.742	ENSCAPG00000009502	IFIH1	100	79.625	Cavia_aperea
ENSG00000115267	IFIH1	61	41.838	ENSCAPG00000016521	DHX58	100	41.838	Cavia_aperea
ENSG00000115267	IFIH1	71	30.894	ENSCAPG00000007816	DDX58	83	31.165	Cavia_aperea
ENSG00000115267	IFIH1	70	40.446	ENSCPOG00000023721	DHX58	99	40.446	Cavia_porcellus
ENSG00000115267	IFIH1	100	82.554	ENSCPOG00000007154	IFIH1	100	82.456	Cavia_porcellus
ENSG00000115267	IFIH1	82	31.784	ENSCPOG00000001598	DDX58	95	31.718	Cavia_porcellus
ENSG00000115267	IFIH1	100	92.390	ENSCCAG00000027248	IFIH1	100	92.390	Cebus_capucinus
ENSG00000115267	IFIH1	97	31.018	ENSCCAG00000036752	DDX58	98	31.525	Cebus_capucinus
ENSG00000115267	IFIH1	70	41.004	ENSCCAG00000022542	DHX58	99	41.004	Cebus_capucinus
ENSG00000115267	IFIH1	97	31.128	ENSCATG00000040246	DDX58	75	34.354	Cercocebus_atys
ENSG00000115267	IFIH1	100	98.146	ENSCATG00000032062	IFIH1	100	98.146	Cercocebus_atys
ENSG00000115267	IFIH1	70	41.283	ENSCATG00000043180	DHX58	95	47.036	Cercocebus_atys
ENSG00000115267	IFIH1	70	40.307	ENSCLAG00000013960	DHX58	99	40.307	Chinchilla_lanigera
ENSG00000115267	IFIH1	100	84.016	ENSCLAG00000008509	IFIH1	100	84.016	Chinchilla_lanigera
ENSG00000115267	IFIH1	83	31.739	ENSCLAG00000002351	DDX58	98	31.130	Chinchilla_lanigera
ENSG00000115267	IFIH1	97	31.323	ENSCSAG00000009834	DDX58	75	32.490	Chlorocebus_sabaeus
ENSG00000115267	IFIH1	70	40.725	ENSCSAG00000003082	DHX58	99	40.725	Chlorocebus_sabaeus
ENSG00000115267	IFIH1	100	98.244	ENSCSAG00000015614	IFIH1	100	98.244	Chlorocebus_sabaeus
ENSG00000115267	IFIH1	68	33.288	ENSCHOG00000009019	DDX58	72	33.288	Choloepus_hoffmanni
ENSG00000115267	IFIH1	80	76.564	ENSCHOG00000013845	IFIH1	84	76.687	Choloepus_hoffmanni
ENSG00000115267	IFIH1	98	31.262	ENSCPBG00000008101	DDX58	99	30.632	Chrysemys_picta_bellii
ENSG00000115267	IFIH1	70	44.770	ENSCPBG00000006804	DHX58	99	44.770	Chrysemys_picta_bellii
ENSG00000115267	IFIH1	99	64.888	ENSCPBG00000026441	IFIH1	99	64.666	Chrysemys_picta_bellii
ENSG00000115267	IFIH1	68	30.404	ENSCING00000009744	-	100	31.010	Ciona_intestinalis
ENSG00000115267	IFIH1	100	97.951	ENSCANG00000031775	IFIH1	100	97.951	Colobus_angolensis_palliatus
ENSG00000115267	IFIH1	70	41.004	ENSCANG00000031041	DHX58	95	46.047	Colobus_angolensis_palliatus
ENSG00000115267	IFIH1	97	31.323	ENSCANG00000031971	DDX58	75	32.490	Colobus_angolensis_palliatus
ENSG00000115267	IFIH1	100	81.171	ENSCGRG00001024740	Ifih1	100	80.116	Cricetulus_griseus_chok1gshd
ENSG00000115267	IFIH1	70	40.387	ENSCGRG00001010336	Dhx58	99	40.526	Cricetulus_griseus_chok1gshd
ENSG00000115267	IFIH1	68	33.516	ENSCGRG00001024123	Ddx58	74	33.063	Cricetulus_griseus_chok1gshd
ENSG00000115267	IFIH1	100	81.171	ENSCGRG00000010637	Ifih1	100	80.116	Cricetulus_griseus_crigri
ENSG00000115267	IFIH1	70	40.387	ENSCGRG00000008364	Dhx58	99	40.526	Cricetulus_griseus_crigri
ENSG00000115267	IFIH1	60	33.699	ENSCGRG00000003581	Ddx58	67	33.705	Cricetulus_griseus_crigri
ENSG00000115267	IFIH1	99	44.477	ENSCSEG00000010056	ifih1	96	50.068	Cynoglossus_semilaevis
ENSG00000115267	IFIH1	70	41.828	ENSCSEG00000021382	dhx58	98	41.828	Cynoglossus_semilaevis
ENSG00000115267	IFIH1	99	47.754	ENSCVAG00000002089	ifih1	94	53.668	Cyprinodon_variegatus
ENSG00000115267	IFIH1	70	41.389	ENSCVAG00000009503	dhx58	98	41.389	Cyprinodon_variegatus
ENSG00000115267	IFIH1	70	43.425	ENSDARG00000089463	dhx58	99	46.341	Danio_rerio
ENSG00000115267	IFIH1	99	48.494	ENSDARG00000018553	ifih1	98	54.965	Danio_rerio
ENSG00000115267	IFIH1	100	86.537	ENSDNOG00000012100	IFIH1	100	86.927	Dasypus_novemcinctus
ENSG00000115267	IFIH1	68	34.658	ENSDNOG00000003968	DDX58	72	34.658	Dasypus_novemcinctus
ENSG00000115267	IFIH1	70	37.657	ENSDNOG00000043127	DHX58	99	37.657	Dasypus_novemcinctus
ENSG00000115267	IFIH1	81	30.599	ENSDORG00000027625	Ddx58	72	33.058	Dipodomys_ordii
ENSG00000115267	IFIH1	70	41.365	ENSDORG00000006815	Dhx58	99	41.365	Dipodomys_ordii
ENSG00000115267	IFIH1	100	83.610	ENSDORG00000001907	Ifih1	100	83.026	Dipodomys_ordii
ENSG00000115267	IFIH1	86	82.022	ENSETEG00000011268	IFIH1	93	67.288	Echinops_telfairi
ENSG00000115267	IFIH1	69	31.250	ENSEBUG00000014150	DDX58	97	30.718	Eptatretus_burgeri
ENSG00000115267	IFIH1	60	43.800	ENSEBUG00000012092	IFIH1	89	43.894	Eptatretus_burgeri
ENSG00000115267	IFIH1	71	41.486	ENSEBUG00000007527	dhx58	99	40.269	Eptatretus_burgeri
ENSG00000115267	IFIH1	70	41.022	ENSEASG00005009112	DHX58	99	41.022	Equus_asinus_asinus
ENSG00000115267	IFIH1	98	83.796	ENSEASG00005022976	IFIH1	100	87.714	Equus_asinus_asinus
ENSG00000115267	IFIH1	83	32.505	ENSEASG00005004589	DDX58	67	35.168	Equus_asinus_asinus
ENSG00000115267	IFIH1	70	40.884	ENSECAG00000011439	DHX58	99	40.884	Equus_caballus
ENSG00000115267	IFIH1	99	86.654	ENSECAG00000007881	IFIH1	99	86.654	Equus_caballus
ENSG00000115267	IFIH1	83	31.389	ENSECAG00000021989	DDX58	77	35.302	Equus_caballus
ENSG00000115267	IFIH1	52	36.871	ENSEEUG00000015254	DDX58	54	36.577	Erinaceus_europaeus
ENSG00000115267	IFIH1	100	80.312	ENSEEUG00000005153	IFIH1	99	80.507	Erinaceus_europaeus
ENSG00000115267	IFIH1	98	48.619	ENSELUG00000019690	ifih1	95	54.633	Esox_lucius
ENSG00000115267	IFIH1	63	37.107	ENSELUG00000005444	-	65	37.107	Esox_lucius
ENSG00000115267	IFIH1	70	42.127	ENSELUG00000018439	dhx58	98	42.127	Esox_lucius
ENSG00000115267	IFIH1	70	34.396	ENSFCAG00000001294	DDX58	75	34.396	Felis_catus
ENSG00000115267	IFIH1	100	84.904	ENSFCAG00000023951	IFIH1	100	84.904	Felis_catus
ENSG00000115267	IFIH1	70	40.782	ENSFCAG00000002145	DHX58	97	40.782	Felis_catus
ENSG00000115267	IFIH1	100	60.635	ENSFALG00000000721	IFIH1	99	60.731	Ficedula_albicollis
ENSG00000115267	IFIH1	65	42.707	ENSFALG00000000653	DHX58	97	42.707	Ficedula_albicollis
ENSG00000115267	IFIH1	92	30.629	ENSFALG00000001146	DDX58	83	33.962	Ficedula_albicollis
ENSG00000115267	IFIH1	51	33.273	ENSFDAG00000011958	-	98	33.455	Fukomys_damarensis
ENSG00000115267	IFIH1	100	81.774	ENSFDAG00000013122	IFIH1	100	81.774	Fukomys_damarensis
ENSG00000115267	IFIH1	70	40.948	ENSFDAG00000018042	DHX58	97	40.948	Fukomys_damarensis
ENSG00000115267	IFIH1	70	40.582	ENSFHEG00000012195	dhx58	98	40.582	Fundulus_heteroclitus
ENSG00000115267	IFIH1	98	47.030	ENSFHEG00000022714	ifih1	97	47.030	Fundulus_heteroclitus
ENSG00000115267	IFIH1	88	49.374	ENSGMOG00000014790	ifih1	90	48.522	Gadus_morhua
ENSG00000115267	IFIH1	70	40.915	ENSGMOG00000015145	dhx58	99	40.915	Gadus_morhua
ENSG00000115267	IFIH1	99	60.916	ENSGALG00000041192	IFIH1	90	60.916	Gallus_gallus
ENSG00000115267	IFIH1	70	43.515	ENSGALG00000023821	DHX58	99	43.515	Gallus_gallus
ENSG00000115267	IFIH1	69	42.757	ENSGAFG00000000986	dhx58	98	42.757	Gambusia_affinis
ENSG00000115267	IFIH1	99	45.490	ENSGAFG00000007593	ifih1	98	45.383	Gambusia_affinis
ENSG00000115267	IFIH1	70	41.667	ENSGACG00000008740	dhx58	98	41.828	Gasterosteus_aculeatus
ENSG00000115267	IFIH1	99	47.410	ENSGACG00000005518	ifih1	98	47.410	Gasterosteus_aculeatus
ENSG00000115267	IFIH1	70	44.909	ENSGAGG00000023270	DHX58	99	44.909	Gopherus_agassizii
ENSG00000115267	IFIH1	98	30.510	ENSGAGG00000018278	DDX58	99	30.221	Gopherus_agassizii
ENSG00000115267	IFIH1	99	63.803	ENSGAGG00000007126	IFIH1	99	63.803	Gopherus_agassizii
ENSG00000115267	IFIH1	100	99.415	ENSGGOG00000015893	IFIH1	100	99.415	Gorilla_gorilla
ENSG00000115267	IFIH1	70	40.446	ENSGGOG00000005458	DHX58	99	40.446	Gorilla_gorilla
ENSG00000115267	IFIH1	97	31.213	ENSGGOG00000016335	DDX58	75	34.800	Gorilla_gorilla
ENSG00000115267	IFIH1	70	42.778	ENSHBUG00000001963	dhx58	98	42.778	Haplochromis_burtoni
ENSG00000115267	IFIH1	70	42.361	ENSHBUG00000001953	dhx58	98	42.361	Haplochromis_burtoni
ENSG00000115267	IFIH1	99	47.689	ENSHBUG00000004855	ifih1	98	47.685	Haplochromis_burtoni
ENSG00000115267	IFIH1	99	83.399	ENSHGLG00000008772	IFIH1	99	83.399	Heterocephalus_glaber_female
ENSG00000115267	IFIH1	69	47.436	ENSHGLG00000011529	DHX58	85	47.436	Heterocephalus_glaber_female
ENSG00000115267	IFIH1	68	35.342	ENSHGLG00000016504	DDX58	73	35.753	Heterocephalus_glaber_female
ENSG00000115267	IFIH1	99	83.399	ENSHGLG00100002141	IFIH1	99	83.399	Heterocephalus_glaber_male
ENSG00000115267	IFIH1	68	35.342	ENSHGLG00100000205	DDX58	73	35.753	Heterocephalus_glaber_male
ENSG00000115267	IFIH1	70	40.167	ENSHGLG00100009705	DHX58	99	40.167	Heterocephalus_glaber_male
ENSG00000115267	IFIH1	70	38.462	ENSHCOG00000004788	dhx58	99	38.462	Hippocampus_comes
ENSG00000115267	IFIH1	98	44.995	ENSHCOG00000016423	ifih1	97	44.797	Hippocampus_comes
ENSG00000115267	IFIH1	72	31.491	ENSIPUG00000003114	ddx58	80	31.105	Ictalurus_punctatus
ENSG00000115267	IFIH1	69	40.922	ENSIPUG00000019893	dhx58	98	40.922	Ictalurus_punctatus
ENSG00000115267	IFIH1	99	49.565	ENSIPUG00000013367	ifih1	99	49.275	Ictalurus_punctatus
ENSG00000115267	IFIH1	69	34.193	ENSSTOG00000006994	DDX58	76	33.641	Ictidomys_tridecemlineatus
ENSG00000115267	IFIH1	100	82.829	ENSSTOG00000004953	IFIH1	100	82.829	Ictidomys_tridecemlineatus
ENSG00000115267	IFIH1	69	41.457	ENSSTOG00000006524	DHX58	98	41.457	Ictidomys_tridecemlineatus
ENSG00000115267	IFIH1	100	79.045	ENSJJAG00000018669	Ifih1	100	78.661	Jaculus_jaculus
ENSG00000115267	IFIH1	70	41.144	ENSJJAG00000000855	Dhx58	99	41.144	Jaculus_jaculus
ENSG00000115267	IFIH1	52	36.898	ENSJJAG00000004582	Ddx58	69	36.898	Jaculus_jaculus
ENSG00000115267	IFIH1	70	42.185	ENSKMAG00000020096	dhx58	99	42.185	Kryptolebias_marmoratus
ENSG00000115267	IFIH1	99	47.736	ENSKMAG00000014309	ifih1	98	46.921	Kryptolebias_marmoratus
ENSG00000115267	IFIH1	69	42.957	ENSLBEG00000004224	dhx58	98	42.957	Labrus_bergylta
ENSG00000115267	IFIH1	98	45.005	ENSLBEG00000005389	ifih1	97	44.926	Labrus_bergylta
ENSG00000115267	IFIH1	72	65.989	ENSLACG00000011448	IFIH1	99	65.989	Latimeria_chalumnae
ENSG00000115267	IFIH1	68	34.250	ENSLACG00000000411	DDX58	72	34.250	Latimeria_chalumnae
ENSG00000115267	IFIH1	70	41.851	ENSLACG00000011208	DHX58	99	41.851	Latimeria_chalumnae
ENSG00000115267	IFIH1	97	31.407	ENSLOCG00000006504	-	98	31.310	Lepisosteus_oculatus
ENSG00000115267	IFIH1	99	53.637	ENSLOCG00000008460	ifih1	99	53.071	Lepisosteus_oculatus
ENSG00000115267	IFIH1	88	30.955	ENSLOCG00000013422	DDX58	76	34.478	Lepisosteus_oculatus
ENSG00000115267	IFIH1	70	44.044	ENSLOCG00000012582	dhx58	99	44.044	Lepisosteus_oculatus
ENSG00000115267	IFIH1	100	84.533	ENSLAFG00000009997	IFIH1	100	84.533	Loxodonta_africana
ENSG00000115267	IFIH1	95	31.287	ENSLAFG00000005416	DDX58	72	34.699	Loxodonta_africana
ENSG00000115267	IFIH1	70	40.443	ENSLAFG00000027301	DHX58	99	40.720	Loxodonta_africana
ENSG00000115267	IFIH1	70	41.144	ENSMFAG00000034530	DHX58	95	46.640	Macaca_fascicularis
ENSG00000115267	IFIH1	100	98.341	ENSMFAG00000003848	IFIH1	100	98.341	Macaca_fascicularis
ENSG00000115267	IFIH1	68	35.577	ENSMFAG00000045674	DDX58	93	35.577	Macaca_fascicularis
ENSG00000115267	IFIH1	70	41.144	ENSMMUG00000014755	DHX58	95	46.640	Macaca_mulatta
ENSG00000115267	IFIH1	100	98.439	ENSMMUG00000003202	IFIH1	100	98.439	Macaca_mulatta
ENSG00000115267	IFIH1	97	31.232	ENSMMUG00000012442	DDX58	98	31.165	Macaca_mulatta
ENSG00000115267	IFIH1	97	31.135	ENSMNEG00000041909	DDX58	98	31.068	Macaca_nemestrina
ENSG00000115267	IFIH1	100	98.244	ENSMNEG00000032734	IFIH1	100	98.244	Macaca_nemestrina
ENSG00000115267	IFIH1	70	41.144	ENSMNEG00000043994	DHX58	95	46.640	Macaca_nemestrina
ENSG00000115267	IFIH1	70	41.144	ENSMLEG00000042616	DHX58	95	46.640	Mandrillus_leucophaeus
ENSG00000115267	IFIH1	100	98.049	ENSMLEG00000000107	IFIH1	100	98.049	Mandrillus_leucophaeus
ENSG00000115267	IFIH1	97	31.226	ENSMLEG00000029982	DDX58	75	34.621	Mandrillus_leucophaeus
ENSG00000115267	IFIH1	99	48.574	ENSMAMG00000003380	ifih1	98	48.130	Mastacembelus_armatus
ENSG00000115267	IFIH1	70	42.659	ENSMAMG00000022316	dhx58	98	42.659	Mastacembelus_armatus
ENSG00000115267	IFIH1	99	47.788	ENSMZEG00005007158	ifih1	98	47.647	Maylandia_zebra
ENSG00000115267	IFIH1	70	42.639	ENSMZEG00005022739	dhx58	98	42.639	Maylandia_zebra
ENSG00000115267	IFIH1	70	41.944	ENSMZEG00005022742	dhx58	99	41.944	Maylandia_zebra
ENSG00000115267	IFIH1	62	42.006	ENSMGAG00000006752	DHX58	99	42.006	Meleagris_gallopavo
ENSG00000115267	IFIH1	99	61.979	ENSMGAG00000010882	IFIH1	99	61.785	Meleagris_gallopavo
ENSG00000115267	IFIH1	69	33.423	ENSMAUG00000021814	Ddx58	75	33.423	Mesocricetus_auratus
ENSG00000115267	IFIH1	70	40.664	ENSMAUG00000019934	Dhx58	99	40.802	Mesocricetus_auratus
ENSG00000115267	IFIH1	98	88.523	ENSMICG00000005405	IFIH1	97	88.523	Microcebus_murinus
ENSG00000115267	IFIH1	70	40.526	ENSMICG00000011933	DHX58	99	40.526	Microcebus_murinus
ENSG00000115267	IFIH1	70	35.952	ENSMICG00000006555	DDX58	95	36.352	Microcebus_murinus
ENSG00000115267	IFIH1	59	39.744	ENSMOCG00000006173	Ddx58	80	32.249	Microtus_ochrogaster
ENSG00000115267	IFIH1	70	40.947	ENSMOCG00000019066	Dhx58	99	40.947	Microtus_ochrogaster
ENSG00000115267	IFIH1	100	80.976	ENSMOCG00000011565	Ifih1	100	80.683	Microtus_ochrogaster
ENSG00000115267	IFIH1	70	40.582	ENSMMOG00000020631	dhx58	98	41.331	Mola_mola
ENSG00000115267	IFIH1	99	46.897	ENSMMOG00000003652	ifih1	98	46.798	Mola_mola
ENSG00000115267	IFIH1	70	41.226	ENSMODG00000014782	DHX58	97	41.226	Monodelphis_domestica
ENSG00000115267	IFIH1	100	71.693	ENSMODG00000005628	IFIH1	99	71.623	Monodelphis_domestica
ENSG00000115267	IFIH1	70	43.448	ENSMALG00000006556	dhx58	98	43.724	Monopterus_albus
ENSG00000115267	IFIH1	97	48.594	ENSMALG00000015489	ifih1	98	48.594	Monopterus_albus
ENSG00000115267	IFIH1	70	42.061	MGP_CAROLIEiJ_G0017181	Dhx58	99	41.922	Mus_caroli
ENSG00000115267	IFIH1	97	30.068	MGP_CAROLIEiJ_G0025893	Ddx58	72	36.412	Mus_caroli
ENSG00000115267	IFIH1	100	79.922	MGP_CAROLIEiJ_G0023594	Ifih1	100	79.727	Mus_caroli
ENSG00000115267	IFIH1	100	79.727	ENSMUSG00000026896	Ifih1	100	79.532	Mus_musculus
ENSG00000115267	IFIH1	70	41.423	ENSMUSG00000017830	Dhx58	99	41.283	Mus_musculus
ENSG00000115267	IFIH1	98	30.162	ENSMUSG00000040296	Ddx58	68	43.689	Mus_musculus
ENSG00000115267	IFIH1	70	41.504	MGP_PahariEiJ_G0018311	Dhx58	99	41.504	Mus_pahari
ENSG00000115267	IFIH1	100	79.455	MGP_PahariEiJ_G0025045	Ifih1	100	79.142	Mus_pahari
ENSG00000115267	IFIH1	51	42.718	MGP_SPRETEiJ_G0026842	Ddx58	68	42.718	Mus_spretus
ENSG00000115267	IFIH1	70	41.562	MGP_SPRETEiJ_G0018024	Dhx58	99	41.423	Mus_spretus
ENSG00000115267	IFIH1	100	80.117	MGP_SPRETEiJ_G0024516	Ifih1	100	79.825	Mus_spretus
ENSG00000115267	IFIH1	70	40.947	ENSMPUG00000010568	DHX58	99	40.947	Mustela_putorius_furo
ENSG00000115267	IFIH1	66	34.795	ENSMPUG00000004319	DDX58	71	34.669	Mustela_putorius_furo
ENSG00000115267	IFIH1	100	83.723	ENSMPUG00000000564	IFIH1	99	83.723	Mustela_putorius_furo
ENSG00000115267	IFIH1	97	30.507	ENSMLUG00000003041	DDX58	75	34.806	Myotis_lucifugus
ENSG00000115267	IFIH1	100	83.431	ENSMLUG00000009505	IFIH1	99	83.041	Myotis_lucifugus
ENSG00000115267	IFIH1	70	40.972	ENSMLUG00000012001	DHX58	99	40.972	Myotis_lucifugus
ENSG00000115267	IFIH1	97	31.250	ENSNGAG00000003642	Ddx58	98	30.507	Nannospalax_galili
ENSG00000115267	IFIH1	70	40.249	ENSNGAG00000017107	Dhx58	99	40.387	Nannospalax_galili
ENSG00000115267	IFIH1	100	82.943	ENSNGAG00000012752	Ifih1	100	82.846	Nannospalax_galili
ENSG00000115267	IFIH1	70	42.127	ENSNBRG00000018515	dhx58	99	42.127	Neolamprologus_brichardi
ENSG00000115267	IFIH1	99	48.177	ENSNBRG00000014585	ifih1	94	54.659	Neolamprologus_brichardi
ENSG00000115267	IFIH1	70	41.528	ENSNBRG00000018263	dhx58	98	41.528	Neolamprologus_brichardi
ENSG00000115267	IFIH1	60	32.109	ENSNLEG00000034971	-	93	32.109	Nomascus_leucogenys
ENSG00000115267	IFIH1	100	93.854	ENSNLEG00000026782	IFIH1	100	93.854	Nomascus_leucogenys
ENSG00000115267	IFIH1	68	37.335	ENSNLEG00000026691	DHX58	98	37.048	Nomascus_leucogenys
ENSG00000115267	IFIH1	81	74.026	ENSMEUG00000003310	IFIH1	81	73.896	Notamacropus_eugenii
ENSG00000115267	IFIH1	70	40.865	ENSMEUG00000005569	DHX58	100	40.865	Notamacropus_eugenii
ENSG00000115267	IFIH1	93	85.714	ENSOPRG00000015760	IFIH1	92	85.714	Ochotona_princeps
ENSG00000115267	IFIH1	52	35.676	ENSOPRG00000016806	-	55	35.676	Ochotona_princeps
ENSG00000115267	IFIH1	70	40.470	ENSOPRG00000000753	DHX58	99	40.470	Ochotona_princeps
ENSG00000115267	IFIH1	100	82.554	ENSODEG00000013586	IFIH1	100	82.554	Octodon_degus
ENSG00000115267	IFIH1	82	30.643	ENSODEG00000015750	DDX58	75	33.377	Octodon_degus
ENSG00000115267	IFIH1	70	40.307	ENSODEG00000017902	DHX58	99	40.307	Octodon_degus
ENSG00000115267	IFIH1	99	47.703	ENSONIG00000008901	ifih1	98	47.600	Oreochromis_niloticus
ENSG00000115267	IFIH1	64	34.902	ENSONIG00000001090	dhx58	99	34.902	Oreochromis_niloticus
ENSG00000115267	IFIH1	72	35.968	ENSOANG00000012131	DDX58	88	35.968	Ornithorhynchus_anatinus
ENSG00000115267	IFIH1	91	66.984	ENSOANG00000006194	IFIH1	97	66.631	Ornithorhynchus_anatinus
ENSG00000115267	IFIH1	100	86.439	ENSOCUG00000002863	IFIH1	99	86.049	Oryctolagus_cuniculus
ENSG00000115267	IFIH1	70	40.552	ENSOCUG00000013278	DHX58	99	40.552	Oryctolagus_cuniculus
ENSG00000115267	IFIH1	97	30.176	ENSOCUG00000004710	DDX58	98	30.848	Oryctolagus_cuniculus
ENSG00000115267	IFIH1	99	46.516	ENSORLG00000016902	ifih1	98	46.516	Oryzias_latipes
ENSG00000115267	IFIH1	70	40.997	ENSORLG00000003825	dhx58	98	40.997	Oryzias_latipes
ENSG00000115267	IFIH1	99	46.850	ENSORLG00020022369	ifih1	98	46.654	Oryzias_latipes_hni
ENSG00000115267	IFIH1	70	40.997	ENSORLG00020008521	dhx58	98	40.997	Oryzias_latipes_hni
ENSG00000115267	IFIH1	99	46.555	ENSORLG00015017957	ifih1	98	46.555	Oryzias_latipes_hsok
ENSG00000115267	IFIH1	70	40.997	ENSORLG00015022015	dhx58	98	40.997	Oryzias_latipes_hsok
ENSG00000115267	IFIH1	55	42.308	ENSOMEG00000023026	dhx58	96	42.831	Oryzias_melastigma
ENSG00000115267	IFIH1	99	46.457	ENSOMEG00000002513	ifih1	98	46.752	Oryzias_melastigma
ENSG00000115267	IFIH1	69	40.865	ENSOMEG00000023054	dhx58	99	40.865	Oryzias_melastigma
ENSG00000115267	IFIH1	70	34.130	ENSOGAG00000010536	DDX58	75	34.794	Otolemur_garnettii
ENSG00000115267	IFIH1	100	85.268	ENSOGAG00000012611	IFIH1	100	85.268	Otolemur_garnettii
ENSG00000115267	IFIH1	70	40.307	ENSOGAG00000025321	DHX58	99	40.307	Otolemur_garnettii
ENSG00000115267	IFIH1	83	31.303	ENSOARG00000014731	DDX58	74	32.537	Ovis_aries
ENSG00000115267	IFIH1	99	83.317	ENSOARG00000006142	IFIH1	99	83.528	Ovis_aries
ENSG00000115267	IFIH1	69	40.808	ENSOARG00000018383	DHX58	98	40.922	Ovis_aries
ENSG00000115267	IFIH1	100	99.610	ENSPPAG00000038665	IFIH1	100	99.610	Pan_paniscus
ENSG00000115267	IFIH1	97	31.115	ENSPPAG00000041750	DDX58	75	34.667	Pan_paniscus
ENSG00000115267	IFIH1	70	40.725	ENSPPAG00000031118	DHX58	99	40.725	Pan_paniscus
ENSG00000115267	IFIH1	70	34.834	ENSPPRG00000010161	DDX58	75	34.834	Panthera_pardus
ENSG00000115267	IFIH1	70	41.061	ENSPPRG00000004933	DHX58	97	41.061	Panthera_pardus
ENSG00000115267	IFIH1	100	84.893	ENSPPRG00000024685	IFIH1	100	84.893	Panthera_pardus
ENSG00000115267	IFIH1	70	41.061	ENSPTIG00000007982	DHX58	97	41.061	Panthera_tigris_altaica
ENSG00000115267	IFIH1	100	84.287	ENSPTIG00000019898	IFIH1	100	84.287	Panthera_tigris_altaica
ENSG00000115267	IFIH1	70	34.834	ENSPTIG00000015345	DDX58	75	34.834	Panthera_tigris_altaica
ENSG00000115267	IFIH1	97	31.115	ENSPTRG00000020844	DDX58	75	34.667	Pan_troglodytes
ENSG00000115267	IFIH1	100	99.512	ENSPTRG00000012582	IFIH1	100	99.512	Pan_troglodytes
ENSG00000115267	IFIH1	70	40.865	ENSPTRG00000009191	DHX58	99	40.865	Pan_troglodytes
ENSG00000115267	IFIH1	97	31.323	ENSPANG00000025269	DDX58	75	34.621	Papio_anubis
ENSG00000115267	IFIH1	98	98.102	ENSPANG00000023890	IFIH1	96	98.102	Papio_anubis
ENSG00000115267	IFIH1	70	41.144	ENSPANG00000021475	DHX58	95	46.640	Papio_anubis
ENSG00000115267	IFIH1	99	48.038	ENSPKIG00000001054	ifih1	99	47.443	Paramormyrops_kingsleyae
ENSG00000115267	IFIH1	70	43.593	ENSPKIG00000020140	dhx58	99	43.593	Paramormyrops_kingsleyae
ENSG00000115267	IFIH1	98	30.271	ENSPSIG00000013490	DDX58	99	30.048	Pelodiscus_sinensis
ENSG00000115267	IFIH1	70	40.222	ENSPSIG00000016525	DHX58	99	40.222	Pelodiscus_sinensis
ENSG00000115267	IFIH1	99	64.272	ENSPSIG00000007364	IFIH1	99	64.175	Pelodiscus_sinensis
ENSG00000115267	IFIH1	70	38.643	ENSPMGG00000010442	dhx58	98	38.643	Periophthalmus_magnuspinnatus
ENSG00000115267	IFIH1	99	45.669	ENSPMGG00000006236	ifih1	95	52.263	Periophthalmus_magnuspinnatus
ENSG00000115267	IFIH1	100	81.366	ENSPEMG00000014586	Ifih1	100	81.366	Peromyscus_maniculatus_bairdii
ENSG00000115267	IFIH1	70	40.884	ENSPEMG00000018681	Dhx58	99	41.022	Peromyscus_maniculatus_bairdii
ENSG00000115267	IFIH1	57	33.667	ENSPMAG00000009697	DDX58	96	33.667	Petromyzon_marinus
ENSG00000115267	IFIH1	52	43.762	ENSPMAG00000007346	-	100	43.575	Petromyzon_marinus
ENSG00000115267	IFIH1	70	41.144	ENSPCIG00000020229	LGP2	99	41.654	Phascolarctos_cinereus
ENSG00000115267	IFIH1	100	73.888	ENSPCIG00000030338	IFIH1	99	75.486	Phascolarctos_cinereus
ENSG00000115267	IFIH1	66	40.529	ENSPCIG00000029320	RIG-I	97	31.911	Phascolarctos_cinereus
ENSG00000115267	IFIH1	99	45.499	ENSPFOG00000017223	ifih1	98	45.597	Poecilia_formosa
ENSG00000115267	IFIH1	70	41.758	ENSPFOG00000011777	dhx58	99	41.758	Poecilia_formosa
ENSG00000115267	IFIH1	99	45.401	ENSPLAG00000000949	ifih1	98	45.544	Poecilia_latipinna
ENSG00000115267	IFIH1	70	41.541	ENSPLAG00000021657	dhx58	96	45.471	Poecilia_latipinna
ENSG00000115267	IFIH1	70	41.621	ENSPMEG00000011404	dhx58	99	41.621	Poecilia_mexicana
ENSG00000115267	IFIH1	99	45.988	ENSPMEG00000016070	ifih1	98	45.597	Poecilia_mexicana
ENSG00000115267	IFIH1	70	41.896	ENSPREG00000010240	dhx58	99	41.896	Poecilia_reticulata
ENSG00000115267	IFIH1	99	45.339	ENSPREG00000007796	ifih1	98	45.196	Poecilia_reticulata
ENSG00000115267	IFIH1	100	96.976	ENSPPYG00000012887	IFIH1	100	96.976	Pongo_abelii
ENSG00000115267	IFIH1	70	34.788	ENSPPYG00000019149	DDX58	79	34.788	Pongo_abelii
ENSG00000115267	IFIH1	98	75.000	ENSPCAG00000007680	IFIH1	100	78.610	Procavia_capensis
ENSG00000115267	IFIH1	57	47.692	ENSPCAG00000016244	DHX58	90	47.692	Procavia_capensis
ENSG00000115267	IFIH1	66	35.502	ENSPCOG00000027117	DDX58	94	35.502	Propithecus_coquereli
ENSG00000115267	IFIH1	70	40.111	ENSPCOG00000021497	DHX58	99	40.111	Propithecus_coquereli
ENSG00000115267	IFIH1	100	87.805	ENSPCOG00000021673	IFIH1	100	87.805	Propithecus_coquereli
ENSG00000115267	IFIH1	70	40.529	ENSPVAG00000003855	DHX58	99	40.669	Pteropus_vampyrus
ENSG00000115267	IFIH1	96	30.146	ENSPVAG00000009207	DDX58	75	33.422	Pteropus_vampyrus
ENSG00000115267	IFIH1	100	81.287	ENSPVAG00000002643	IFIH1	100	80.702	Pteropus_vampyrus
ENSG00000115267	IFIH1	99	47.586	ENSPNYG00000002971	ifih1	98	47.488	Pundamilia_nyererei
ENSG00000115267	IFIH1	70	42.361	ENSPNYG00000010782	dhx58	99	42.538	Pundamilia_nyererei
ENSG00000115267	IFIH1	61	53.623	ENSPNYG00000010709	dhx58	98	53.623	Pundamilia_nyererei
ENSG00000115267	IFIH1	70	42.039	ENSPNAG00000028648	dhx58	98	42.039	Pygocentrus_nattereri
ENSG00000115267	IFIH1	98	48.980	ENSPNAG00000023802	ifih1	97	49.563	Pygocentrus_nattereri
ENSG00000115267	IFIH1	71	32.737	ENSPNAG00000002347	-	75	32.737	Pygocentrus_nattereri
ENSG00000115267	IFIH1	100	79.455	ENSRNOG00000006227	Ifih1	100	79.455	Rattus_norvegicus
ENSG00000115267	IFIH1	70	41.713	ENSRNOG00000018247	Dhx58	99	41.713	Rattus_norvegicus
ENSG00000115267	IFIH1	70	41.004	ENSRBIG00000028906	DHX58	95	46.245	Rhinopithecus_bieti
ENSG00000115267	IFIH1	97	97.984	ENSRBIG00000029188	IFIH1	99	97.984	Rhinopithecus_bieti
ENSG00000115267	IFIH1	91	32.083	ENSRBIG00000040257	DDX58	96	34.887	Rhinopithecus_bieti
ENSG00000115267	IFIH1	97	31.226	ENSRROG00000029512	DDX58	75	34.887	Rhinopithecus_roxellana
ENSG00000115267	IFIH1	100	98.146	ENSRROG00000030959	IFIH1	100	98.146	Rhinopithecus_roxellana
ENSG00000115267	IFIH1	64	38.763	ENSRROG00000035891	DHX58	95	46.245	Rhinopithecus_roxellana
ENSG00000115267	IFIH1	100	92.585	ENSSBOG00000026205	IFIH1	100	92.585	Saimiri_boliviensis_boliviensis
ENSG00000115267	IFIH1	97	31.024	ENSSBOG00000030627	DDX58	96	31.055	Saimiri_boliviensis_boliviensis
ENSG00000115267	IFIH1	70	41.365	ENSSBOG00000020589	DHX58	99	41.365	Saimiri_boliviensis_boliviensis
ENSG00000115267	IFIH1	100	72.991	ENSSHAG00000017981	IFIH1	100	73.114	Sarcophilus_harrisii
ENSG00000115267	IFIH1	70	41.355	ENSSHAG00000006130	DHX58	100	41.355	Sarcophilus_harrisii
ENSG00000115267	IFIH1	93	30.242	ENSSFOG00015017386	ddx58	73	33.513	Scleropages_formosus
ENSG00000115267	IFIH1	70	43.115	ENSSFOG00015023124	dhx58	99	43.115	Scleropages_formosus
ENSG00000115267	IFIH1	99	52.977	ENSSFOG00015022705	ifih1	97	56.421	Scleropages_formosus
ENSG00000115267	IFIH1	70	40.720	ENSSMAG00000007427	dhx58	99	40.720	Scophthalmus_maximus
ENSG00000115267	IFIH1	99	46.072	ENSSMAG00000012345	ifih1	97	52.959	Scophthalmus_maximus
ENSG00000115267	IFIH1	99	48.431	ENSSDUG00000019000	ifih1	98	48.333	Seriola_dumerili
ENSG00000115267	IFIH1	70	41.967	ENSSDUG00000022971	dhx58	98	42.105	Seriola_dumerili
ENSG00000115267	IFIH1	70	41.828	ENSSLDG00000017659	dhx58	98	41.828	Seriola_lalandi_dorsalis
ENSG00000115267	IFIH1	99	48.235	ENSSLDG00000016351	ifih1	98	48.137	Seriola_lalandi_dorsalis
ENSG00000115267	IFIH1	75	34.528	ENSSARG00000008445	DDX58	78	30.132	Sorex_araneus
ENSG00000115267	IFIH1	56	49.138	ENSSARG00000002192	DHX58	76	49.138	Sorex_araneus
ENSG00000115267	IFIH1	76	86.735	ENSSARG00000002581	IFIH1	75	86.735	Sorex_araneus
ENSG00000115267	IFIH1	70	43.715	ENSSPUG00000012993	DHX58	99	43.715	Sphenodon_punctatus
ENSG00000115267	IFIH1	69	33.515	ENSSPUG00000002608	DDX58	92	30.041	Sphenodon_punctatus
ENSG00000115267	IFIH1	100	62.379	ENSSPUG00000017377	IFIH1	100	61.896	Sphenodon_punctatus
ENSG00000115267	IFIH1	70	42.798	ENSSPAG00000006485	dhx58	98	42.798	Stegastes_partitus
ENSG00000115267	IFIH1	99	49.201	ENSSPAG00000000528	ifih1	98	48.917	Stegastes_partitus
ENSG00000115267	IFIH1	70	40.771	ENSSSCG00000017416	DHX58	99	40.771	Sus_scrofa
ENSG00000115267	IFIH1	99	84.990	ENSSSCG00000015897	IFIH1	99	85.091	Sus_scrofa
ENSG00000115267	IFIH1	82	31.591	ENSSSCG00000030408	DDX58	94	31.312	Sus_scrofa
ENSG00000115267	IFIH1	100	60.501	ENSTGUG00000006914	IFIH1	100	60.618	Taeniopygia_guttata
ENSG00000115267	IFIH1	68	33.106	ENSTGUG00000001516	DDX58	74	33.106	Taeniopygia_guttata
ENSG00000115267	IFIH1	70	43.115	ENSTGUG00000002516	DHX58	99	43.115	Taeniopygia_guttata
ENSG00000115267	IFIH1	98	44.423	ENSTRUG00000001413	ifih1	95	51.318	Takifugu_rubripes
ENSG00000115267	IFIH1	70	40.166	ENSTRUG00000015710	dhx58	98	40.166	Takifugu_rubripes
ENSG00000115267	IFIH1	69	40.473	ENSTNIG00000011713	dhx58	98	40.414	Tetraodon_nigroviridis
ENSG00000115267	IFIH1	99	45.278	ENSTNIG00000016500	ifih1	99	45.278	Tetraodon_nigroviridis
ENSG00000115267	IFIH1	100	76.390	ENSTBEG00000005625	IFIH1	100	76.000	Tupaia_belangeri
ENSG00000115267	IFIH1	56	46.923	ENSTBEG00000005427	DHX58	79	46.923	Tupaia_belangeri
ENSG00000115267	IFIH1	76	30.855	ENSTTRG00000016993	DDX58	88	31.501	Tursiops_truncatus
ENSG00000115267	IFIH1	70	40.634	ENSTTRG00000006650	DHX58	99	40.634	Tursiops_truncatus
ENSG00000115267	IFIH1	99	80.195	ENSTTRG00000013780	IFIH1	99	79.844	Tursiops_truncatus
ENSG00000115267	IFIH1	100	84.600	ENSUAMG00000015811	IFIH1	100	84.600	Ursus_americanus
ENSG00000115267	IFIH1	70	40.417	ENSUAMG00000024348	DHX58	99	40.417	Ursus_americanus
ENSG00000115267	IFIH1	69	35.047	ENSUAMG00000020703	DDX58	73	35.047	Ursus_americanus
ENSG00000115267	IFIH1	98	84.044	ENSUMAG00000012031	IFIH1	98	84.143	Ursus_maritimus
ENSG00000115267	IFIH1	69	35.047	ENSUMAG00000005813	DDX58	77	35.047	Ursus_maritimus
ENSG00000115267	IFIH1	70	38.583	ENSUMAG00000023000	DHX58	99	38.583	Ursus_maritimus
ENSG00000115267	IFIH1	85	79.519	ENSVPAG00000010823	IFIH1	99	79.519	Vicugna_pacos
ENSG00000115267	IFIH1	70	39.698	ENSVVUG00000020914	DHX58	99	39.698	Vulpes_vulpes
ENSG00000115267	IFIH1	70	33.554	ENSVVUG00000021149	DDX58	79	33.554	Vulpes_vulpes
ENSG00000115267	IFIH1	99	83.252	ENSVVUG00000018569	IFIH1	99	83.252	Vulpes_vulpes
ENSG00000115267	IFIH1	69	42.637	ENSXETG00000002302	dhx58	98	42.637	Xenopus_tropicalis
ENSG00000115267	IFIH1	85	31.568	ENSXETG00000009200	ddx58	95	31.462	Xenopus_tropicalis
ENSG00000115267	IFIH1	100	54.062	ENSXETG00000013176	ifih1	100	54.062	Xenopus_tropicalis
ENSG00000115267	IFIH1	99	46.010	ENSXCOG00000019338	ifih1	98	45.813	Xiphophorus_couchianus
ENSG00000115267	IFIH1	70	41.551	ENSXMAG00000008899	dhx58	98	41.551	Xiphophorus_maculatus
ENSG00000115267	IFIH1	99	46.018	ENSXMAG00000011536	ifih1	98	46.010	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003725	double-stranded RNA binding	19656871.	IDA	Function
GO:0003725	double-stranded RNA binding	17079289.	TAS	Function
GO:0003727	single-stranded RNA binding	19656871.	IDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	16127453.17460044.17600090.19403670.19416887.20434986.21156324.21791617.21903422.22301138.22328336.22623778.22908223.23328395.25865883.30193849.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008270	zinc ion binding	19380577.19531363.	IDA	Function
GO:0009597	detection of virus	17079289.	TAS	Process
GO:0009615	response to virus	21616437.	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016925	protein sumoylation	21156324.	IDA	Process
GO:0032480	negative regulation of type I interferon production	-	TAS	Process
GO:0032727	positive regulation of interferon-alpha production	19656871.	IMP	Process
GO:0032727	positive regulation of interferon-alpha production	17079289.	TAS	Process
GO:0032728	positive regulation of interferon-beta production	17600090.	IDA	Process
GO:0032728	positive regulation of interferon-beta production	19211564.19656871.	IMP	Process
GO:0032728	positive regulation of interferon-beta production	17079289.	TAS	Process
GO:0034344	regulation of type III interferon production	21616437.	TAS	Process
GO:0035549	positive regulation of interferon-beta secretion	21957149.	IMP	Process
GO:0039528	cytoplasmic pattern recognition receptor signaling pathway in response to virus	21616437.	TAS	Process
GO:0039530	MDA-5 signaling pathway	17600090.	IDA	Process
GO:0042802	identical protein binding	22160685.25865883.	IPI	Function
GO:0043021	ribonucleoprotein complex binding	19881509.	IPI	Function
GO:0045087	innate immune response	21616437.	TAS	Process
GO:0051607	defense response to virus	21478870.	IDA	Process
GO:0060760	positive regulation of response to cytokine stimulus	21957149.	IMP	Process
GO:0071360	cellular response to exogenous dsRNA	21957149.	IMP	Process
GO:1902741	positive regulation of interferon-alpha secretion	21957149.	IMP	Process
GO:1904469	positive regulation of tumor necrosis factor secretion	21957149.	IMP	Process
GO:2000778	positive regulation of interleukin-6 secretion	21957149.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.