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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27902486ED-B fibronectin expression is a marker of epithelial-mesenchymal transition in translational oncology.Oncotarget2017 Jan 17Petrini Idoi: 10.18632/oncotarget.13615.
28716814Potency-matched Dual Cytokine-Antibody Fusion Proteins for Cancer Therapy.Mol Cancer Ther2017 NovDe Luca Rdoi: 10.1158/1535-7163.MCT-17-0211
20530259Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility.J Immunol2010 Jul 1Solinas Gdoi: 10.4049/jimmunol.1000413
23684510Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer.Hum Pathol2013 OctBae YKdoi: 10.1016/j.humpath.2013.03.006
22496919The extra domain A of fibronectin increases VEGF-C expression in colorectal carcinoma involving the PI3K/AKT signaling pathway.PLoS One2012Xiang Ldoi: 10.1371/journal.pone.0035378
23912459Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice.Oncogene2014 Jun 26Serres Edoi: 10.1038/onc.2013.305
20007695Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4.J Biol Chem2010 Mar 5Saito Ydoi: 10.1074/jbc.M109.027581
22918248Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.Cell Cycle2012 Sep 15Carito Vdoi: 10.4161/cc.21701
20012564Diagnostic value of fibronectin and mutant p53 in the urine of patients with bladder cancer: impact on clinicopathological features and disease recurrence.Med Oncol2010 DecEissa Sdoi: 10.1007/s12032-009-9375-9
21036738Up-regulation of fibronectin and tissue transglutaminase promotes cell invasion involving increased association with integrin and MMP expression in A431 cells.Anticancer Res2010 OctChen SH-
20359090[Expression and pathobiological significance of Col I, Col IV and Fn in laryngeal squamous cell carcinomas].Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi2009 DecZhang H-
28535003miRNA1271 inhibits cell proliferation in neuroglioma by targeting fibronectin 1.Mol Med Rep2017 JulGong Jdoi: 10.3892/mmr.2017.6610
30314454Expression of fibronectin in esophageal squamous cell carcinoma and its role in migration.BMC Cancer2018 Oct 12Xiao Jdoi: 10.1186/s12885-018-4850-3.
30736807Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma.World J Surg Oncol2019 Feb 8Hu Ddoi: 10.1186/s12957-019-1574-z.
19893454Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer.Pancreas2009 OctRyschich Edoi: 10.1097/MPA.0b013e3181b9dfda.
19161998Presence of high-molecular-weight forms and domain alterations of fibronectin in pleural effusion of patients with lung cancer.Clin Biochem2009 MayPupek Mdoi: 10.1016/j.clinbiochem.2008.12.018
15384859[Elevated expression of matrix metalloproteinase-9, and fibronectin concentration in recurrent epithelial ovarian cancer].Orv Hetil2004 Aug 1Demeter A-
29021221Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.J Cell Biol2017 Nov 6Erdogan Bdoi: 10.1083/jcb.201704053
28972876miR-200b regulates epithelial-mesenchymal transition of chemo-resistant breast cancer cells by targeting FN1.Discov Med2017 SepYang X-
30396333Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells.BMC Cancer2018 Nov 5Yoshimura Adoi: 10.1186/s12885-018-4974-5.
24919860A single nucleotide polymorphism in fibronectin 1 determines tumor shape in colorectal cancer.Oncol Rep2014 AugKida Hdoi: 10.3892/or.2014.3251
28113080MicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells.Biomed Pharmacother2017 AprZhang Hdoi: 10.1016/j.biopha.2017.01.023
15467744Fibronectin and type IV collagen activate ERalpha AF-1 by c-Src pathway: effect on breast cancer cell motility.Oncogene2004 Nov 25Sisci D-
21472136Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin.Neoplasia2011 AprPark JH-
25202979Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.J Clin Invest2014 OctKenny HAdoi: 10.1172/JCI74778
25885552Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression.BMC Cancer2015 Apr 11Full??r Adoi: 10.1186/s12885-015-1272-3.
18006840The extra-domain A of fibronectin is a vascular marker of solid tumors and metastases.Cancer Res2007 Nov 15Rybak JN-
20145126Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin.Cancer Res2010 Feb 15Hwangbo Cdoi: 10.1158/0008-5472.CAN-09-2447
26964871Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer.Carcinogenesis2016 MayWu Jdoi: 10.1093/carcin/bgw029
25962506Urolithin A causes p21 up-regulation in prostate cancer cells.Eur J Nutr2016 AprS??nchez-Gonz??lez Cdoi: 10.1007/s00394-015-0924-z
20201928Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin.Alcohol Clin Exp Res2010 MayXu Mdoi: 10.1111/j.1530-0277.2010.01147.x
24743511Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition.Carcinogenesis2014 JulOu Jdoi: 10.1093/carcin/bgu090
20860816Fibronectin 1 mRNA expression correlates with advanced disease in renal cancer.BMC Cancer2010 Sep 22Waalkes Sdoi: 10.1186/1471-2407-10-503.
18340378The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.J Clin Invest2008 AprKenny HAdoi: 10.1172/JCI33775.
23895273SOX2 targets fibronectin 1 to promote cell migration and invasion in ovarian cancer: new molecular leads for therapeutic intervention.OMICS2013 OctLou Xdoi: 10.1089/omi.2013.0058
23653350Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway.J Biol Chem2013 Jun 21Balanis Ndoi: 10.1074/jbc.M113.475277
18829569The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis.Cancer Res2008 Oct 1Liu Wdoi: 10.1158/0008-5472.CAN-08-2132.
17512904Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression.Biochem Biophys Res Commun2007 Jul 6Yang Z-
25284724Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin.Breast Cancer Res Treat2014 NovHong Hdoi: 10.1007/s10549-014-3154-9
21691075Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and β1 integrin activation.Cell Physiol Biochem2011Lee HAdoi: 10.1159/000329979
27748871High expression of fibronectin is associated with poor prognosis, cell proliferation and malignancy via the NF-??B/p53-apoptosis signaling pathway in colorectal cancer.Oncol Rep2016 DecYi Wdoi: 10.3892/or.2016.5177
19935699Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells.Oncogene2010 Jan 28Yang Ldoi: 10.1038/onc.2009.370
20939933N-terminal and C-terminal heparin-binding domain polypeptides derived from fibronectin reduce adhesion and invasion of liver cancer cells.BMC Cancer2010 Oct 13Tang NHdoi: 10.1186/1471-2407-10-552.
158906701alpha,25-Dihydroxyvitamin D3 targets PTEN-dependent fibronectin expression to restore thyroid cancer cell adhesiveness.Mol Endocrinol2005 SepLiu W-
18958156In vitro identification and characterization of CD133(pos) cancer stem-like cells in anaplastic thyroid carcinoma cell lines.PLoS One2008Zito Gdoi: 10.1371/journal.pone.0003544
27465556Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation.Tumour Biol2016 OctQin S-
18776591Fibronectin pattern in benign hyperplasia and cancer of the prostate.Dis Markers2008Jankovi MM-
27693493miR-1207-3p regulates the androgen receptor in prostate cancer via FNDC1/fibronectin.Exp Cell Res2016 Nov 1Das DKdoi: 10.1016/j.yexcr.2016.09.021
27207836Silence of fibronectin 1 increases cisplatin sensitivity of non-small cell lung cancer cell line.Biochem Biophys Res Commun2016 Jul 15Gao Wdoi: 10.1016/j.bbrc.2016.05.081
27173027Fibronectin-1 expression is increased in aggressive thyroid cancer and favors the migration and invasion of cancer cells.Mol Cell Endocrinol2016 Aug 15Sponziello Mdoi: 10.1016/j.mce.2016.05.007
27498393Quantitative proteomics revealed novel proteins associated with molecular subtypes of breast cancer.J Proteomics2016 Oct 4Suman Sdoi: 10.1016/j.jprot.2016.07.033
27250024Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer.Oncotarget2016 Jun 28Moon PGdoi: 10.18632/oncotarget.9561.
27503584Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions.Matrix Biol2017 JulWang Kdoi: 10.1016/j.matbio.2016.08.001
27715399Proteolytic fragments of fibronectin function as matrikines driving the chemotactic affinity of prostate cancer cells to human bone marrow mesenchymal stromal cells via the α5β1 integrin.Cell Adh Migr2017 Jul 4Joshi Rdoi: 10.1080/19336918.2016.1212139
28765903Wild-type p53 controls the level of fibronectin expression in breast cancer cells.Oncol Rep2017 OctYou Ddoi: 10.3892/or.2017.5860
29391407Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion.Sci Rep2018 Feb 1Armstrong HKdoi: 10.1038/s41598-018-19871-4.
29274284Down-regulation of FN1 inhibits colorectal carcinogenesis by suppressing proliferation, migration, and invasion.J Cell Biochem2018 JunCai Xdoi: 10.1002/jcb.26651

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2215379280SilentnovelV1733V0.48
ACCchr2215434735Missense_MutationnovelG80R0.13
BLCAchr2215422146Silentrs746335179T497T0.27
BLCAchr2215428230Missense_MutationNAR265Q0.22
BLCAchr2215397734Missense_MutationnovelV1155F0.84
BLCAchr2215365557Missense_MutationnovelM2273I0.26
BLCAchr2215380880Missense_MutationNAY1698H0.13
BLCAchr2215361562Missense_Mutationrs369527578R2385Q0.14
BLCAchr2215408138Missense_MutationNAR830C0.15
BLCAchr2215384963Silentrs142628915P1451P0.6
BLCAchr2215365523Missense_MutationnovelE2285K0.17
BLCAchr2215409637Missense_MutationnovelS742L0.31
BLCAchr2215422093Missense_MutationnovelR515P0.15
BLCAchr2215384123Silentrs374970848S1506S0.24
BLCAchr2215414773Intronnovel0.24
BLCAchr2215375705SilentNAG1876G0.35
BLCAchr2215409623Missense_Mutationrs776884669V747M0.34
BLCAchr2215425185SilentnovelV315V0.6
BLCAchr2215372320Frame_Shift_InsnovelL2011Ifs*500.26
BLCAchr2215419350Nonsense_MutationnovelQ571*0.45
BLCAchr2215384078SilentnovelV1521V0.38
BLCAchr2215414755Intronnovel0.75
BLCAchr2215414841Missense_MutationnovelR646T0.63
BLCAchr2215414795Intronnovel0.17
BLCAchr2215372247Missense_MutationnovelQ2035E0.13
BLCAchr2215368014Missense_MutationnovelL2198F0.48
BLCAchr2215394665Missense_MutationnovelS1220C0.13
BLCAchr2215391734Missense_MutationnovelI1293V0.37
BLCAchr2215391696SilentNAV1305V0.1
BLCAchr2215371926Missense_MutationnovelD2142N0.26
BLCAchr2215414894SilentnovelI628I0.92
BLCAchr2215394606Missense_Mutationrs767515823G1240S0.05
BLCAchr2215393125Intronnovel0.6
BLCAchr2215409958Missense_MutationnovelT700P0.21
BLCAchr2215414926Missense_MutationnovelE618Q0.19
BLCAchr2215406401SilentnovelV941V0.24
BLCAchr2215408180Missense_MutationNAD816N0.05
BLCAchr2215379232Silentrs767001317L1749L0.86
BLCAchr2215372116Silentrs145436721P2078P0.32
BLCAchr2215375638Missense_Mutationrs573992192A1899T0.39
BLCAchr2215372337Missense_MutationNAL2005V0.55
BLCAchr2215372035SilentnovelL2105L0.15
BRCAchr2215397809Nonsense_MutationNAE1130*0.18
BRCAchr2215372118Missense_MutationNAP2078T0.2
BRCAchr2215391904IntronNA0.08
BRCAchr2215381283Intronnovel0.06
BRCAchr2215392966IntronNA0.36
BRCAchr2215367895Frame_Shift_DelnovelK2230Wfs*80.21
BRCAchr2215379497Intronnovel0.27
BRCAchr2215397838Missense_MutationNAR1120P0.22
BRCAchr2215431921SilentNAT153T0.14
BRCAchr2215433415SilentnovelV108V0.17
BRCAchr2215419344Missense_MutationNAG573R0.44
BRCAchr2215399314Missense_MutationNAE1097D0.35
BRCAchr2215423424Missense_MutationNAR440I0.43
BRCAchr2215434699Missense_Mutationrs750176227E92K0.28
BRCAchr2215382173Intronnovel0.38
BRCAchr2215361587Missense_Mutationrs149294265V2377I0.25
BRCAchr2215433421SilentNAY106Y0.19
BRCAchr2215364889Missense_MutationnovelG2323E0.1
BRCAchr2215406284SilentNAV980V0.36
BRCAchr2215384891SilentnovelV1475V0.23
BRCAchr2215379376Intronnovel0.12
BRCAchr2215408138Missense_MutationNAR830C0.29
BRCAchr2215410025Silentrs368252734Y677Y0.13
BRCAchr2215424268Missense_MutationnovelT365S0.05
BRCAchr2215397136Splice_SitenovelX1198_splice0.14
BRCAchr2215384214Intronnovel0.18
BRCAchr2215382064Intronnovel0.43
BRCAchr2215425162Missense_MutationNAL323P0.12
BRCAchr2215406437Silentrs375777163P929P0.23
BRCAchr2215433408Missense_MutationnovelT111A0.05
BRCAchr2215361569Missense_MutationnovelD2383N0.07
BRCAchr2215404552Silentrs367816616T1030T0.26
CESCchr2215370425Missense_MutationNAV2150A0.18
CESCchr2215386786SilentnovelT1414T0.64
CESCchr2215375638Missense_Mutationrs573992192A1899T0.53
CESCchr22153608233'UTRnovel0.64
CESCchr2215378181Missense_MutationNAL1811V0.29
CESCchr2215381120Intronnovel0.1
CESCchr2215383461Missense_MutationnovelM1548I0.4
CESCchr2215384940Missense_Mutationrs202245868A1459V0.18
CESCchr2215391716Missense_MutationnovelL1299M0.17
CESCchr2215407191SilentnovelV883V0.12
CESCchr2215361987SilentNAY2357Y0.53
CESCchr2215375229Missense_MutationNAE1957K0.51
CESCchr2215408117Missense_MutationNAP837S0.65
CESCchr2215408149Nonsense_MutationNAS826*0.58
CESCchr2215367882SilentnovelH2242H0.09
CESCchr2215425240Missense_MutationnovelQ297R0.29
CESCchr2215433346SilentNAG131G0.33
CESCchr2215382093Intronnovel0.44
CHOLchr2215409988Frame_Shift_InsnovelQ690Kfs*300.01
COADchr2215381052Missense_MutationNAF1640L0.18
COADchr2215394606Missense_Mutationrs767515823G1240S0.27
COADchr2215372025Missense_MutationNAA2109S0.35
COADchr2215407314Missense_MutationNAR842S0.4
COADchr2215424304Missense_MutationNAG353D0.35
COADchr2215392952Intronnovel0.11
COADchr2215386857Missense_Mutationrs116558455R1391C0.15
COADchr2215424308Missense_Mutationrs13306372G352S0.38
COADchr22154358245'UTRnovel0.45
COADchr2215386957Splice_RegionnovelG1357G0.18
COADchr2215422223Missense_MutationnovelT472A0.09
COADchr2215384071Missense_MutationNAR1524C0.17
COADchr2215409725Nonsense_MutationnovelG713*0.26
COADchr2215425242Silentrs201079072P296P0.18
COADchr2215372373Missense_Mutationrs775650652E1993K0.28
COADchr2215433349SilentnovelR130R0.05
COADchr2215408423Missense_MutationNAL768P0.3
COADchr2215364934Missense_MutationNAW2308L0.26
COADchr22153613133'UTRnovel0.59
COADchr2215433404Frame_Shift_DelNAT111Mfs*80.48
COADchr2215430838Frame_Shift_InsnovelD188*0.17
COADchr2215391760Missense_MutationnovelR1284H0.16
COADchr2215383451Missense_Mutationrs140153061D1552N0.28
COADchr2215373411Missense_MutationnovelG1962V0.32
COADchr2215404577Missense_MutationNAA1022V0.26
COADchr2215364898Missense_MutationNAT2320I0.39
COADchr2215391706Missense_MutationnovelY1302C0.3
COADchr2215430736Missense_Mutationrs748170344R222C0.19
COADchr2215384123Silentrs374970848S1506S0.21
COADchr2215379235SilentnovelQ1748Q0.18
COADchr2215384939Silentrs144486467A1459A0.14
COADchr2215406243Missense_MutationNAT994K0.38
COADchr2215386800SilentNAR1410R0.44
COADchr2215409675Silentrs147004347T729T0.23
COADchr2215370391SilentNAG2161G0.27
COADchr2215375243Missense_Mutationrs770932448R1952H0.41
COADchr2215379262Silentrs376598003S1739S0.17
COADchr2215406437Silentrs375777163P929P0.25
COADchr2215425250Missense_MutationnovelY294H0.17
COADchr2215362031Nonsense_MutationnovelE2343*0.38
COADchr2215384731Intronnovel0.28
COADchr2215407302Silentrs145300210S846S0.36
COADchr2215365533Silentrs568449322N2281N0.42
COADchr2215397798SilentNAS1133S0.1
COADchr2215407308SilentNAV844V0.12
COADchr2215408375Missense_Mutationrs772449186R784Q0.13
COADchr2215423521Missense_MutationNAV408I0.16
COADchr2215367940Missense_MutationNAR2223Q0.38
COADchr2215372249Missense_MutationNAI2034S0.27
COADchr2215409985Nonsense_MutationNAE691*0.36
COADchr2215420783Missense_MutationNAD522G0.31
COADchr2215380832Frame_Shift_DelNAL1714*0.2
COADchr2215406267Missense_MutationnovelS986N0.09
COADchr2215375638Missense_Mutationrs573992192A1899T0.06
COADchr2215375306Missense_MutationNAT1931I0.28
COADchr2215419278Missense_MutationNAG595R0.54
COADchr2215393030Intronrs5402310020.36
COADchr2215408375Missense_Mutationrs772449186R784Q0.28
COADchr2215424192Silentrs745915615S390S0.19
COADchr2215428325Missense_MutationNAD233E0.08
COADchr2215365559Missense_MutationnovelM2273V0.04
COADchr2215378239Frame_Shift_DelnovelS1791Rfs*90.07
COADchr2215386856Missense_Mutationrs369288293R1391H0.1
COADchr2215397827Missense_MutationnovelG1124R0.24
COADchr2215375324Missense_Mutationrs139452116P1925L0.35
COADchr2215391738Frame_Shift_InsNAS1292Ifs*30.34
DLBCchr2215425243Missense_Mutationrs145123731P296L0.35
ESCAchr2215391757Missense_MutationnovelV1285A0.17
ESCAchr22154358675'UTRNA0.33
ESCAchr2215420713Nonsense_MutationnovelC545*0.12
ESCAchr2215384943Missense_MutationnovelA1458V0.07
ESCAchr2215372284Silentrs776023777F2022F0.28
GBMchr2215372284Silentrs776023777F2022F0.15
GBMchr2215406409Missense_MutationnovelV939L0.09
GBMchr2215410102Missense_MutationnovelG652S0.09
GBMchr2215423448Frame_Shift_DelnovelT432Mfs*120.2
GBMchr2215383480Missense_MutationnovelI1542N0.08
GBMchr2215379206Missense_MutationnovelP1758L0.25
GBMchr2215391845Intronnovel0.06
GBMchr2215419327Frame_Shift_InsnovelK578Nfs*410.03
GBMchr2215394700SilentnovelI1208I0.08
GBMchr2215372061Missense_MutationnovelH2097D0.04
GBMchr2215384144Missense_MutationnovelS1499R0.06
GBMchr2215367961Missense_MutationnovelA2216V0.24
GBMchr2215375693Missense_MutationnovelK1880N0.27
GBMchr2215397706Missense_Mutationrs183891852A1164V0.24
GBMchr2215407275Missense_MutationNAE855D0.11
GBMchr2215362072Missense_Mutationrs372963822R2329H0.15
GBMchr2215367959Missense_MutationNAV2217L0.26
HNSCchr2215424242Missense_MutationnovelC374S0.05
HNSCchr2215384076Missense_MutationnovelT1522N0.38
HNSCchr2215406318Frame_Shift_DelnovelP969Lfs*120.35
HNSCchr2215414741Intronnovel0.35
HNSCchr2215419287Missense_MutationnovelR592S0.17
HNSCchr2215419346Missense_MutationnovelI572N0.3
HNSCchr2215433459Missense_MutationNAE94K0.26
HNSCchr2215434734Missense_MutationnovelG80V0.18
HNSCchr2215386811Missense_MutationnovelV1406G0.24
HNSCchr2215422163Missense_MutationnovelH492D0.17
HNSCchr2215407292Missense_MutationnovelE850K0.26
HNSCchr2215404540SilentnovelT1034T0.53
HNSCchr2215397847Missense_MutationnovelL1117R0.31
HNSCchr2215409994Missense_Mutationrs375296345G688S0.15
HNSCchr2215380701Intronnovel0.07
HNSCchr2215428234Missense_MutationNAG264S0.32
HNSCchr2215404525SilentnovelP1039P0.33
HNSCchr2215383344SilentnovelT1587T0.22
HNSCchr2215375644Missense_MutationnovelI1897L0.38
HNSCchr2215424193Nonsense_MutationnovelS390*0.15
HNSCchr2215404538Missense_Mutationrs199915234R1035Q0.35
HNSCchr2215370345Missense_MutationnovelD2177N0.11
HNSCchr2215370362Missense_MutationnovelI2171T0.29
KICHchr2215382041Intronnovel0.33
KIRCchr2215425093Splice_SitenovelX346_splice0.29
KIRCchr2215372269SilentNAG2027G0.26
KIRCchr2215380931Missense_MutationNAD1681H0.15
KIRCchr2215397728Missense_MutationNAR1157G0.33
KIRCchr2215410052Missense_MutationNAI668M0.25
KIRCchr2215430749SilentNAG217G0.08
KIRCchr2215433408Missense_MutationnovelT111P0.29
KIRPchr2215404416Missense_MutationnovelP1076S0.29
KIRPchr2215406350SilentNAR958R0.15
KIRPchr2215409953Missense_MutationNAS701R0.24
KIRPchr2215367869Missense_MutationNAS2247P0.32
KIRPchr2215425204Missense_MutationNAV309G0.39
LAMLchr2215375213Splice_SiteNAX1962_splice0.08
LAMLchr2215391830Intronnovel0.14
LGGchr2215365546Missense_MutationnovelT2277I0.05
LGGchr2215420795Missense_MutationnovelC518Y0.39
LGGchr2215428313Missense_MutationnovelR237S0.38
LGGchr2215423491Frame_Shift_InsnovelA418Sfs*300.09
LIHCchr2215384940Missense_MutationNAA1459E0.13
LIHCchr2215394703Missense_MutationnovelR1207S0.4
LIHCchr2215381276Intronnovel0.83
LIHCchr2215376508SilentNAY1868Y0.45
LIHCchr2215373321Splice_Siters111852829X1992_splice0.14
LIHCchr2215408328Missense_MutationnovelS800G0.37
LIHCchr2215397178Missense_MutationnovelT1188N0.34
LIHCchr2215397188Missense_Mutationrs746992481N1185D0.16
LIHCchr2215379173Missense_MutationnovelN1769I0.16
LIHCchr2215434787Frame_Shift_DelnovelQ63Sfs*70.48
LIHCchr2215391658Missense_MutationNAP1318H0.31
LIHCchr2215406235Splice_Regionnovel0.38
LIHCchr2215434800Missense_MutationnovelH58R0.45
LIHCchr2215382108Intronnovel0.25
LIHCchr2215383451Missense_Mutationrs140153061D1552N0.2
LIHCchr2215362073Missense_Mutationrs759273898R2329C0.08
LIHCchr2215384279Intronnovel0.29
LIHCchr2215384089Frame_Shift_InsnovelV1518Cfs*200.32
LIHCchr2215397189SilentNAA1184A0.21
LIHCchr2215406373Missense_Mutationrs772017194G951R0.35
LUADchr2215407207Missense_MutationnovelI878N0.15
LUADchr2215420677Silentrs767104145P557P0.49
LUADchr2215420678Missense_MutationnovelP557H0.49
LUADchr2215419283Missense_MutationnovelG593V0.26
LUADchr2215419284Missense_MutationnovelG593C0.27
LUADchr2215397811Missense_MutationNAR1129P0.43
LUADchr2215397805Missense_MutationnovelV1131G0.06
LUADchr2215409713Missense_MutationNAP717T0.13
LUADchr2215431948SilentNAG144G0.18
LUADchr2215361563Frame_Shift_DelnovelR2385Efs*240.21
LUADchr2215384090SilentNAT1517T0.29
LUADchr2215394557Frame_Shift_DelnovelE1255Cfs*50.04
LUADchr2215365557Missense_MutationnovelM2273I0.35
LUADchr2215397749Missense_Mutationrs767986025V1150I0.12
LUADchr2215422100Nonsense_MutationNAQ513*0.3
LUADchr22153614963'UTRnovel0.16
LUADchr2215404444SilentnovelL1066L0.2
LUADchr2215393044IntronNA0.23
LUADchr2215430784Nonsense_MutationnovelQ206*0.16
LUADchr2215407305Silentrs753408362Y845Y0.1
LUADchr2215382326Splice_SiteNAX1593_splice0.22
LUADchr2215386770Missense_MutationnovelP1420T0.27
LUADchr2215384036SilentnovelS1535S0.19
LUADchr2215419361Missense_MutationnovelG567V0.09
LUADchr2215408346Missense_MutationnovelS794P0.15
LUADchr2215408192Missense_MutationNAD812N0.22
LUADchr2215397755Nonsense_MutationNAE1148*0.11
LUADchr2215430794Frame_Shift_InsnovelK203Efs*260.24
LUSCchr2215431854Missense_MutationNAE176Q0.04
LUSCchr2215379201Missense_MutationnovelE1760K0.25
LUSCchr2215386861SilentnovelR1389R0.17
LUSCchr2215408343Missense_MutationnovelE795K0.31
LUSCchr2215435749Silentrs149268490G18G0.73
LUSCchr2215383442Missense_MutationNAD1555H0.36
LUSCchr2215365623Nonsense_MutationnovelC2251*0.16
LUSCchr2215365619Missense_MutationnovelD2253H0.18
LUSCchr2215423413Nonsense_MutationNAK444*0.51
LUSCchr2215425232Missense_MutationNAP300T0.1
LUSCchr2215425100Missense_Mutationrs769681616E344K0.32
LUSCchr2215384768Intronnovel0.21
LUSCchr2215425112Missense_MutationNAV340I0.32
LUSCchr2215428288Missense_MutationnovelW246G0.14
LUSCchr2215425241Missense_MutationnovelQ297E0.55
LUSCchr2215408119Missense_Mutationrs746363370A836D0.13
LUSCchr2215428328SilentNAN232N0.45
LUSCchr2215409718Missense_Mutationrs144664306T715M0.33
LUSCchr2215393162Intronrs7641498160.27
LUSCchr2215433435Missense_MutationNAT102S0.12
LUSCchr2215422225Missense_MutationnovelT471K0.26
LUSCchr2215379258Missense_MutationnovelQ1741K0.54
LUSCchr2215420747Missense_MutationNAR534P0.07
LUSCchr2215404555SilentNAL1029L0.19
LUSCchr2215380766Intronnovel0.14
LUSCchr2215394549Missense_MutationNAI1259V0.34
LUSCchr2215406272Missense_MutationnovelR984S0.31
LUSCchr2215383437Missense_MutationnovelN1556K0.35
LUSCchr2215431884Missense_MutationnovelE166Q0.35
LUSCchr2215419368Missense_MutationNAE565Q0.1
LUSCchr2215384889Missense_MutationnovelR1476K0.24
LUSCchr2215382293Missense_MutationNAP1604T0.5
LUSCchr2215384321Intronnovel0.38
LUSCchr2215420752Missense_MutationNAH532Q0.21
LUSCchr2215367955Missense_MutationnovelG2218A0.21
LUSCchr2215386958Missense_MutationNAG1357D0.2
LUSCchr2215431884Missense_MutationnovelE166Q0.11
LUSCchr2215420767SilentNAV527V0.13
LUSCchr2215424290Missense_MutationNAE358Q0.16
LUSCchr2215375352Missense_MutationnovelP1916A0.41
LUSCchr2215372122Nonsense_MutationnovelY2076*0.16
LUSCchr2215420682Missense_MutationnovelD556N0.23
LUSCchr2215382312Missense_MutationNAM1597I0.18
LUSCchr2215433452Missense_Mutationrs756996869T96I0.29
MESOchr2215406414Missense_MutationnovelY937C0.14
OVchr2215383412Missense_MutationnovelS1565P0.04
OVchr2215425212SilentnovelG306G0.05
OVchr2215362065Missense_Mutationrs150636748D2331E0.52
OVchr2215394688SilentNAP1212P0.26
OVchr2215420734Frame_Shift_DelnovelG538Afs*180.04
OVchr2215373337Nonsense_MutationnovelG1987*0.03
OVchr2215381119Intronnovel0.06
OVchr2215372373Nonsense_MutationnovelE1993*0.19
OVchr2215370386Missense_MutationNAT2163S0.43
OVchr2215384679Intronnovel0.1
OVchr2215391904IntronNA0.11
OVchr2215384237Intronnovel0.25
OVchr2215408352Missense_Mutationrs745416782Q792E0.25
OVchr2215428251Missense_MutationNAC258Y0.34
OVchr2215384180SilentnovelG1487G0.05
OVchr2215430736Missense_Mutationrs748170344R222C0.48
OVchr2215380922Frame_Shift_InsnovelE1684*0.04
OVchr2215422181Frame_Shift_InsnovelK486Gfs*110.08
OVchr2215422182Frame_Shift_InsnovelD485Efs*180.07
OVchr2215381072Missense_MutationnovelR1634C0.09
OVchr2215424193Missense_Mutationrs201876289S390L0.25
PAADchr2215382260Missense_MutationnovelQ1615E0.09
PAADchr2215424148Missense_MutationnovelT405I0.2
PAADchr2215375303Missense_MutationnovelG1932D0.05
PAADchr2215384870Silentrs147150819Y1482Y0.13
PAADchr2215386723Silentrs754043219E1435E0.05
PAADchr2215393162Intronrs7641498160.13
PAADchr2215428228Nonsense_MutationnovelG266*0.18
PAADchr2215407133Missense_MutationnovelR903C0.04
PAADchr2215410056Missense_MutationnovelT667I0.5
PAADchr2215423496Missense_Mutationrs181283286N416S0.46
PCPGchr2215399323SilentnovelY1094Y0.33
PCPGchr2215408386SilentnovelL780L0.27
PRADchr2215425107Silentrs138120768S341S0.06
PRADchr2215397749Missense_MutationnovelV1150F0.12
PRADchr2215394639Nonsense_MutationNAQ1229*0.04
PRADchr2215404409Missense_Mutationrs775917038A1078V0.06
PRADchr2215379216Missense_MutationnovelR1755W0.14
READchr2215361583Missense_MutationNAQ2378R0.25
READchr2215433398Missense_MutationNAR114H0.3
READchr2215386846Silentrs764031352P1394P0.32
READchr2215384192Splice_Regionnovel0.38
READchr2215404468SilentNAP1058P0.24
READchr2215383451Missense_Mutationrs140153061D1552N0.26
READchr2215414843Missense_MutationnovelW645C0.26
READchr2215394709SilentNAG1205G0.08
READchr2215375324Missense_Mutationrs139452116P1925L0.22
READchr2215424175Missense_MutationnovelQ396R0.28
READchr22153613283'UTRrs5729683500.41
READchr2215373394Missense_Mutationrs767081660E1968K0.5
READchr2215375323Silentrs752013950P1925P0.43
READchr2215379527Intronnovel1
READchr2215380473Intronnovel0.6
READchr2215384815Intronnovel0.42
READchr2215391866Intronnovel0.36
READchr2215407178Nonsense_MutationNAE888*0.38
READchr2215381283Intronnovel0.11
READchr2215361565Missense_MutationnovelS2384Y0.43
READchr2215375671Missense_MutationnovelD1888Y0.09
READchr2215384726Intronnovel0.48
READchr2215384847Intronnovel0.38
SARCchr2215379183Missense_Mutationrs755018889K1766E0.47
SARCchr22153610103'UTRnovel0.53
SARCchr2215423353Missense_MutationnovelA464T0.22
SARCchr22153611573'UTRnovel0.16
SARCchr2215380686Intronnovel0.27
SARCchr2215394561Missense_MutationnovelE1255K0.36
SKCMchr2215433375Missense_MutationNAD122N0.2
SKCMchr2215386895Nonsense_MutationnovelW1378*0.64
SKCMchr2215424193Missense_Mutationrs201876289S390L0.28
SKCMchr2215424217Missense_MutationnovelG382E0.5
SKCMchr2215420678Missense_Mutationrs201863538P557L0.17
SKCMchr2215425262Missense_MutationNAR290C0.31
SKCMchr2215428307SilentNAS239S0.38
SKCMchr2215375345Missense_MutationNAS1918F0.27
SKCMchr2215388244Missense_MutationNAE1346V0.35
SKCMchr2215408420Missense_MutationnovelP769L0.22
SKCMchr2215430720Missense_MutationnovelS227F0.55
SKCMchr2215361596Missense_MutationNAP2374S0.31
SKCMchr2215425177Missense_MutationnovelV318E0.46
SKCMchr2215419244Missense_MutationNAP606L0.37
SKCMchr2215414934Missense_MutationNAF615S0.61
SKCMchr2215423471SilentnovelF424F0.09
SKCMchr2215409674Missense_Mutationrs778879562E730K0.32
SKCMchr22153615403'UTRnovel0.33
SKCMchr2215386826Missense_MutationnovelP1401L0.37
SKCMchr2215386827Missense_MutationnovelP1401S0.37
SKCMchr2215365599SilentNAK2259K0.23
SKCMchr2215406498Missense_MutationNAS909F0.25
SKCMchr2215425150Missense_MutationNAG327E0.33
SKCMchr2215404399SilentnovelV1081V0.18
SKCMchr2215404400Missense_MutationnovelV1081G0.18
SKCMchr2215386837SilentNAF1397F0.14
SKCMchr2215424193Missense_Mutationrs201876289S390L0.11
SKCMchr2215382240Frame_Shift_InsnovelS1621Rfs*100.25
SKCMchr2215391856Intronnovel0.79
SKCMchr2215388302Splice_SiteNAX1327_splice0.37
SKCMchr2215383484Splice_SiteNAX1541_splice0.58
SKCMchr2215362080Splice_SitenovelX2327_splice0.33
SKCMchr2215394562SilentnovelK1254K0.41
SKCMchr2215380826Missense_MutationNAG1716R0.22
SKCMchr2215409646Missense_MutationNAS739F0.5
SKCMchr2215406377SilentNAE949E0.56
SKCMchr2215372206Missense_MutationNAQ2048H0.38
SKCMchr2215375213Splice_SiteNAX1962_splice0.09
SKCMchr2215404525SilentnovelP1039P0.48
SKCMchr2215397835Missense_MutationnovelP1121L0.34
SKCMchr2215367932Missense_MutationNAE2226K0.15
SKCMchr2215433332Missense_MutationNAT136I0.43
SKCMchr2215386734Missense_MutationNAN1432Y0.32
SKCMchr2215384737Intronnovel0.45
SKCMchr2215399273Missense_MutationNAP1111L0.26
SKCMchr2215375262Missense_MutationNAE1946K0.14
SKCMchr2215419252SilentnovelQ603Q0.63
STADchr2215397680Missense_MutationNAP1173S0.38
STADchr2215408398SilentNAN776N0.21
STADchr2215380973Missense_MutationnovelS1667P0.14
STADchr2215408196Splice_Regionrs751168230A810A0.28
STADchr2215424227Nonsense_MutationNAR379*0.19
STADchr2215394692Missense_MutationNAT1211N0.33
STADchr2215422129Missense_Mutationrs552465703R503H0.38
STADchr2215408121SilentnovelQ835Q0.4
STADchr2215428307SilentnovelS239S0.36
STADchr2215435673Missense_MutationnovelA44T0.1
STADchr2215367960Silentrs372228808A2216A0.06
STADchr2215406354Missense_MutationnovelS957N0.13
STADchr2215362059SilentNAC2333C0.18
STADchr2215364900SilentNAC2319C0.21
STADchr2215380704Intronnovel0.22
STADchr2215383452Silentrs374393885T1551T0.24
STADchr2215379261Missense_Mutationrs753498044A1740T0.15
STADchr2215362073Missense_Mutationrs759273898R2329C0.27
STADchr2215409639SilentnovelV741V0.31
STADchr2215409640Missense_MutationnovelV741D0.29
STADchr2215378259Missense_MutationNAA1785T0.32
STADchr2215410107Missense_MutationNAS650Y0.32
STADchr2215379262Silentrs376598003S1739S0.27
STADchr2215382249Silentrs778102824S1618S0.33
STADchr2215435680SilentnovelS41S0.28
STADchr2215386889Missense_MutationNAA1380V0.33
STADchr2215380809Splice_SiteNAX1721_splice0.05
STADchr2215404468SilentNAP1058P0.08
STADchr2215408116Missense_MutationNAP837L0.18
STADchr2215408353Nonsense_MutationNAY791*0.07
STADchr2215435789Missense_MutationNAP5L0.3
STADchr2215380926SilentNAG1682G0.29
STADchr2215380784Intronnovel0.04
STADchr2215381011Missense_MutationnovelS1654N0.22
STADchr2215407134SilentnovelP902P0.34
STADchr2215373348Frame_Shift_DelnovelE1983Gfs*30.4
STADchr2215388277Missense_MutationNAV1335A0.1
STADchr2215393104Intronnovel0.18
STADchr2215392965Intronrs7601289570.29
STADchr2215386793Missense_Mutationrs748907647S1412F0.08
STADchr2215368003Missense_Mutationrs750419825T2202M0.49
STADchr2215375282Missense_MutationNAK1939T0.35
STADchr2215404523Missense_MutationnovelR1040K0.32
STADchr2215409618Silentrs760287619S748S0.32
STADchr2215394583SilentnovelV1247V0.28
STADchr2215414766Intronrs7703936590.35
STADchr2215428242Missense_MutationNAT261I0.08
STADchr2215375369Missense_Mutationrs749462589R1910H0.24
STADchr2215384818Intronnovel0.16
STADchr2215424227Nonsense_MutationNAR379*0.31
STADchr2215372162Missense_MutationNAP2063H0.24
STADchr2215409682Missense_MutationnovelS727Y0.21
STADchr2215392988Intronrs3756424910.28
STADchr2215407214Missense_MutationNAY876H0.1
STADchr2215409665Missense_MutationNAA733T0.36
STADchr2215434754SilentNAA73A0.33
STADchr2215408175Silentrs765229420T817T0.28
STADchr2215372209SilentNAG2047G0.14
STADchr2215384906SilentNAA1470A0.15
STADchr2215375370Missense_Mutationrs538117654R1910C0.21
STADchr2215414727Intronnovel0.38
STADchr2215393053IntronNA0.25
STADchr2215404388Splice_SiteNAX1085_splice0.18
STADchr2215433399Missense_MutationNAR114C0.22
THCAchr2215420747Missense_MutationNAR534P0.34
THYMchr2215419264Nonsense_MutationnovelC599*0.08
UCECchr2215393003IntronNA0.31
UCECchr2215399270Missense_MutationNAR1112I0.34
UCECchr22153613803'UTRnovel0.09
UCECchr2215406466Missense_MutationNAD920Y0.32
UCECchr2215407302Silentrs145300210S846S0.28
UCECchr2215392960Intronnovel0.46
UCECchr2215404409Missense_Mutationrs775917038A1078V0.35
UCECchr2215414941Missense_MutationNAE613K0.25
UCECchr2215435774Missense_MutationnovelL10R0.47
UCECchr22154359555'UTRnovel0.47
UCECchr2215373399Missense_Mutationrs779541074G1966V0.45
UCECchr2215375311SilentNAR1929R0.34
UCECchr2215379222Nonsense_MutationNAR1753*0.28
UCECchr2215382070Intronnovel0.19
UCECchr2215384309Intronnovel0.47
UCECchr2215406374Silentrs138522820H950H0.33
UCECchr2215414851Missense_MutationNAL643I0.14
UCECchr2215423477SilentNAF422F0.32
UCECchr22153613423'UTRnovel0.38
UCECchr22153615513'UTRrs7674056380.45
UCECchr2215382073Intronnovel0.29
UCECchr2215384778Intronnovel0.53
UCECchr2215393104Intronnovel0.5
UCECchr2215397782Missense_Mutationrs201181695V1139I0.55
UCECchr2215422094Nonsense_MutationnovelR515*0.29
UCECchr2215428288Missense_MutationnovelW246R0.14
UCECchr22153608133'UTRnovel0.3
UCECchr22153611463'UTRnovel0.29
UCECchr2215397773Missense_MutationnovelG1142S0.31
UCECchr2215372010Missense_MutationNAE2114K0.38
UCECchr2215376508SilentNAY1868Y0.45
UCECchr2215381176Intronnovel0.43
UCECchr2215382165Intronnovel0.52
UCECchr2215383451Missense_Mutationrs140153061D1552N0.48
UCECchr2215394665Missense_Mutationrs764928095S1220Y0.45
UCECchr2215404399Silentrs550005362V1081V0.31
UCECchr2215408319Missense_MutationNAL803M0.41
UCECchr2215431854Nonsense_MutationNAE176*0.4
UCECchr2215375267Missense_MutationNAP1944L0.42
UCECchr2215386883Missense_MutationnovelR1382L0.28
UCECchr22154358795'UTRnovel0.39
UCECchr2215391836Intronnovel0.42
UCECchr2215397753Missense_MutationnovelE1148D0.32
UCECchr2215404595Missense_MutationnovelR1016I0.39
UCECchr2215422093Missense_Mutationrs376696206R515Q0.47
UCECchr2215423387SilentnovelY452Y0.33
UCECchr2215399270Missense_MutationNAR1112I0.3
UCECchr2215379325Splice_Regionnovel0.41
UCECchr2215383361Missense_MutationnovelP1582S0.41
UCECchr2215406235Splice_Regionnovel0.33
UCECchr2215425093Splice_SitenovelX346_splice0.48
UCECchr2215406241Missense_MutationnovelT995A0.28
UCECchr2215409629Missense_Mutationrs765671126D745N0.14
UCECchr2215424256Missense_MutationnovelR369M0.12
UCECchr2215420674Splice_RegionNAV558V0.5
UCECchr2215397783Silentrs200468961I1138I0.22
UCECchr2215380856Missense_MutationNAH1706Y0.15
UCECchr2215384953Missense_MutationNAE1455K0.36
UCECchr2215404521Nonsense_MutationNAQ1041*0.45
UCECchr2215373327Frame_Shift_DelnovelK1990Dfs*390.5
UCECchr2215430834Missense_MutationNAH189R0.4
UCECchr2215364918Silentrs749250118L2313L0.18
UCECchr2215393105Intronrs5635140460.09
UCECchr2215394606Missense_Mutationrs767515823G1240S0.41
UCECchr2215423422Missense_MutationNAD441Y0.15
UCECchr2215383410SilentNAS1565S0.28
UCECchr2215394539Missense_MutationnovelT1262I0.18
UCECchr2215408111Missense_MutationnovelT839A0.16
UCECchr2215409942Missense_MutationnovelP705L0.2
UCECchr2215382182Intronnovel0.33
UCECchr2215375677SilentNAL1886L0.43
UCECchr2215381209Intronnovel0.47
UCECchr2215408369Missense_MutationnovelY786C0.07
UCECchr2215430853Splice_SitenovelX183_splice0.24
UCECchr2215422094Nonsense_MutationnovelR515*0.34
UCECchr2215379196Missense_MutationnovelK1761N0.53
UCECchr2215399270Missense_MutationNAR1112I0.1
UCECchr2215404610Missense_MutationnovelS1011Y0.38
UCECchr2215409674Missense_Mutationrs778879562E730K0.41
UCECchr2215372088Missense_MutationnovelH2088N0.07
UCECchr2215404532Missense_MutationnovelG1037E0.29
UCECchr2215424146Missense_MutationnovelV406I0.19
UCECchr2215428314Missense_MutationnovelR237M0.06
UCECchr2215430788SilentnovelP204P0.32
UCECchr2215406379Missense_Mutationrs770425267E949K0.37
UCECchr2215409960Missense_MutationnovelT699I0.06
UCECchr2215375369Missense_Mutationrs749462589R1910H0.33
UCECchr2215397679Splice_SitenovelX1173_splice0.28
UCECchr22154358375'UTRnovel0.34
UCECchr2215407302Silentrs145300210S846S0.37
UCECchr22153608743'UTRnovel0.49
UCECchr2215423501Missense_MutationnovelN414K0.32
UCECchr2215408137Missense_Mutationrs775576039R830H0.1
UCECchr22153610633'UTRnovel0.15
UCECchr2215386823Missense_Mutationrs760692030R1402Q0.43
UCECchr2215367935Missense_MutationnovelS2225P0.35
UCECchr2215404582SilentnovelP1020P0.26
UCECchr2215407302Silentrs145300210S846S0.47
UCECchr2215414884Missense_MutationnovelA632T0.45
UCECchr2215420722Silentrs138144264N542N0.41
UCECchr2215431833Missense_MutationnovelA183S0.05
UCECchr2215434746Missense_MutationnovelC76Y0.34
UCECchr2215391689Nonsense_MutationnovelE1308*0.32
UCECchr2215430714Splice_SitenovelX229_splice0.32
UCECchr2215361616Missense_MutationNAC2367Y0.31
UCECchr2215384286Intronnovel0.53
UCECchr2215388299Missense_MutationnovelL1328I0.38
UCECchr2215392962Intronnovel0.52
UCECchr2215397162SilentnovelV1193V0.52
UCECchr2215382171Intronnovel0.26
UCECchr2215375249Missense_Mutationrs746145647R1950Q0.25
UCECchr2215431960SilentnovelR140R0.07
UCECchr2215406334Missense_MutationNAV964L0.49
UCECchr2215434701Missense_MutationNAP91H0.33
UCECchr2215371958Missense_MutationnovelE2131A0.22
UCECchr2215364947Missense_Mutationrs561274088V2304I0.25
UCECchr2215407183Missense_MutationnovelN886T0.51
UCECchr2215408369Missense_MutationnovelY786C0.29
UCECchr2215378211Missense_MutationnovelS1801G0.3
UCECchr2215406329Silentrs757338869T965T0.3
UCECchr2215379443Intronnovel0.14
UCECchr2215379444Intronnovel0.14
UCECchr2215420732Missense_MutationnovelH539R0.5
UCECchr2215423426SilentnovelR439R0.2
UCECchr2215420743SilentnovelH535H0.25
UCECchr2215379205Frame_Shift_DelnovelK1759Rfs*70.42
UCECchr2215391871Intronnovel0.25
UCECchr2215423520Missense_MutationnovelV408A0.29
UCECchr22153610423'UTRnovel0.33
UCECchr2215367941Nonsense_MutationNAR2223*0.46
UCECchr2215373349Missense_MutationnovelE1983K0.43
UCECchr2215381037Silentrs767979509V1645V0.43
UCECchr2215382117Intronnovel0.23
UCECchr2215383408Missense_MutationnovelS1566I0.34
UCECchr2215384869Missense_Mutationrs764285223G1483R0.5
UCECchr2215388224Missense_MutationnovelR1353G0.47
UCECchr2215394682Silentrs781399494N1214N0.42
UCECchr22153606863'UTRnovel0.31
UCECchr2215361603SilentnovelC2371C0.4
UCECchr2215365523Missense_MutationnovelE2285K0.44
UCECchr2215375290Missense_MutationnovelK1936N0.5
UCECchr2215381036Missense_Mutationrs762429904D1646N0.61
UCECchr2215404452Missense_Mutationrs142401055V1064I0.37
UCECchr2215406437Silentrs375777163P929P0.42
UCECchr2215425120Missense_MutationnovelG337D0.38
UCECchr2215425242Silentrs201079072P296P0.7
UCECchr2215431934Missense_MutationnovelK149T0.37
UCECchr2215424212Missense_MutationNAL384I0.31
UCECchr2215406464Silentrs764538393D920D0.41
UCECchr2215391661Missense_MutationnovelS1317Y0.17
UCECchr2215384286Intronnovel0.18
UCECchr2215384778Intronnovel0.28
UCECchr2215399270Missense_MutationNAR1112I0.21
UCECchr2215406293SilentNAV977V0.32
UCECchr2215408375Missense_Mutationrs772449186R784Q0.29
UCECchr2215425262Missense_MutationNAR290C0.32
UCECchr22153608533'UTRnovel0.16
UCECchr2215388254Missense_MutationNAE1343K0.13
UCECchr22153607853'UTRnovel0.23
UCECchr2215368022Missense_MutationNAE2196K0.44
UCECchr2215393024Intronnovel0.21
UCECchr2215375244Missense_Mutationrs781268073R1952C0.83
UCECchr2215384070Missense_MutationnovelR1524H0.27
UCECchr2215367903Missense_MutationnovelC2235W0.45
UCECchr2215382193Intronnovel0.28
UCECchr2215391911Intronnovel0.33
UCECchr2215397156Missense_MutationnovelW1195C0.19
UCECchr2215365504Splice_Siters112323657X2291_splice0.45
UCECchr2215391709Missense_Mutationrs745854917R1301H0.12
UCECchr22154359555'UTRnovel0.4
UCECchr2215376648Missense_MutationNAV1822M0.04
UCECchr2215384730Intronnovel0.33
UCECchr2215430785SilentnovelY205Y0.25
UCECchr2215386954In_Frame_InsnovelL1358_D1359insRA0.07
UCECchr2215410091Missense_MutationNAK655N0.38
UCECchr2215381061SilentNAG1637G0.27
UCECchr2215368023Silentrs555829524N2195N0.21
UCECchr2215404476SilentNAL1056L0.26
UCECchr2215414941Missense_MutationNAE613K0.25
UCECchr2215425262Missense_MutationNAR290C0.26
UCECchr2215372288Missense_MutationnovelP2021H0.07
UCECchr2215422239Silentrs752449773H466H0.49
UCECchr2215404656Splice_SiteNAX996_splice0.17
UCECchr2215425282Missense_MutationNAS283Y0.34
UCECchr2215433428Missense_MutationnovelN104T0.1
UCECchr22153608773'UTRnovel0.06
UCECchr2215425094Missense_MutationnovelA346S0.43
UCECchr2215386954In_Frame_InsnovelL1358_D1359insRA0.1
UCECchr2215409960Nonsense_MutationnovelT699Sfs*80.04
UCECchr2215391791Nonsense_Mutationrs779973526R1274*0.07
UCECchr22153615453'UTRrs3769048730.22
UCECchr2215376659Missense_MutationnovelR1818I0.25
UCECchr2215379362Intronnovel0.21
UCECchr2215381283Intronnovel0.21
UCECchr2215384940Missense_Mutationrs202245868A1459V0.44
UCECchr2215399321Missense_MutationnovelN1095S0.33
UCECchr2215407204Missense_MutationnovelT879I0.19
UCECchr2215414809Intronnovel0.19
UCECchr2215414898Missense_MutationnovelP627L0.19
UCECchr2215428328SilentNAN232N0.46
UCECchr2215394665Missense_Mutationrs764928095S1220Y0.31
UCECchr2215424192Silentrs745915615S390S0.51
UCECchr2215372202Missense_MutationnovelM2050L0.56
UCECchr2215365548SilentNAC2276C0.32
UCECchr2215367892Missense_MutationNAG2239V0.32
UCECchr2215425262Missense_MutationNAR290C0.36
UCECchr2215380853Missense_Mutationrs775247659D1707N0.52
UCECchr2215361569Missense_MutationnovelD2383N0.37
UCECchr2215384056Missense_Mutationrs766780476A1529T0.43
UCECchr2215384159SilentnovelF1494F0.37
UCECchr2215404435Missense_MutationnovelI1069M0.49
UCECchr2215424212Missense_MutationNAL384I0.42
UCECchr2215397143Missense_MutationnovelT1200A0.34
UCECchr2215399254Splice_Regionnovel0.48
UCECchr2215406370Nonsense_MutationnovelQ952*0.47
UCECchr2215384891SilentnovelV1475V0.25
UCSchr2215373394Missense_Mutationrs767081660E1968K0.04
UCSchr2215379323Splice_Regionnovel0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
HNSCDEL0.21461.278e-25
KIRPDEL0.03135.174e-05
LUSCDEL0.23751.3904e-19
MESODEL0.12640.014499
PAADAMP0.07070.1091
PAADDEL0.0380.2014
THCADEL0.0240.040844

Survival Analysis
CancerP-value Q-value
STAD0.0028

Kaplan-Meier Survival Analysis

SARC0.015

Kaplan-Meier Survival Analysis

MESO0.00014

Kaplan-Meier Survival Analysis

ACC0.0045

Kaplan-Meier Survival Analysis

HNSC0.031

Kaplan-Meier Survival Analysis

LUSC0.0046

Kaplan-Meier Survival Analysis

ESCA0.045

Kaplan-Meier Survival Analysis

KIRP0.00059

Kaplan-Meier Survival Analysis

COAD0.039

Kaplan-Meier Survival Analysis

PAAD0.019

Kaplan-Meier Survival Analysis

BLCA0.00011

Kaplan-Meier Survival Analysis

CESC0.00064

Kaplan-Meier Survival Analysis

KICH0.015

Kaplan-Meier Survival Analysis

UCEC0.038

Kaplan-Meier Survival Analysis

GBM0.0038

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

UVM0.00073

Kaplan-Meier Survival Analysis

OV0.048

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000115414 (Gene tree)
Gene ID
2335
Gene Symbol
FN1
Alias
MSF|CIG|LETS|GFND2|FINC
Full Name
fibronectin 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
75,733 bases
Position
chr2:215,360,440-215,436,172
Accession
3778
RBP type
non-canonical RBP
Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23236287Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.PLoS Genet2012Ding Ddoi: 10.1371/journal.pgen.1003065
16168628Identification of a pre-mRNA splicing factor, arginine/serine-rich 3 (Sfrs3), and its co-expression with fibronectin in fetal and postnatal rabbit airway mucosal and skin wounds.Biochim Biophys Acta2006 JanLi-Korotky HS-
19366727LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor.J Cell Sci2009 May 1Ying Ldoi: 10.1242/jcs.025957
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000323926FN1-2018708XM_005246399ENSP000003235342446 (aa)XP_005246456P02751
ENST00000456923FN1-2133720-ENSP000004161391103 (aa)-H0Y7Z1
ENST00000490833FN1-223699--- (aa)--
ENST00000471193FN1-217496--- (aa)--
ENST00000354785FN1-2038905XM_005246397ENSP000003468392477 (aa)XP_005246454P02751
ENST00000336916FN1-2028435-ENSP000003382002355 (aa)-P02751
ENST00000473614FN1-218568--- (aa)--
ENST00000359671FN1-2068524XM_005246404ENSP000003526962386 (aa)XP_005246461P02751
ENST00000356005FN1-2047846XM_005246412ENSP000003482852296 (aa)XP_016859184P02751
ENST00000496542FN1-226695--- (aa)--
ENST00000432072FN1-2097759XM_005246403ENSP000003995382267 (aa)XP_005246460P02751
ENST00000480737FN1-221384--- (aa)--
ENST00000494446FN1-225676--- (aa)--
ENST00000438981FN1-210723-ENSP00000392565241 (aa)-H0Y4K8
ENST00000461974FN1-215571--- (aa)--
ENST00000421182FN1-2078103XM_005246416ENSP000003944232240 (aa)XP_005246473P02751
ENST00000446046FN1-2127952-ENSP000004104222330 (aa)-P02751
ENST00000498719FN1-2272433--- (aa)--
ENST00000443816FN1-2117762-ENSP000004150182265 (aa)-P02751
ENST00000480024FN1-220576--- (aa)--
ENST00000469569FN1-216629--- (aa)--
ENST00000426059FN1-2082388-ENSP00000398907657 (aa)-P02751
ENST00000357867FN1-2057898-ENSP000003505342176 (aa)-P02751
ENST00000492816FN1-2249171--- (aa)--
ENST00000485567FN1-222584--- (aa)--
ENST00000460217FN1-214804--- (aa)--
ENST00000474036FN1-2191058--- (aa)--
Gene Model
Click here to download ENSG00000115414's gene model file
Pathways
Pathway IDPathway NameSource
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04510Focal adhesionKEGG
hsa04512ECM-receptor interactionKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa04933AGE-RAGE signaling pathway in diabetic complicationsKEGG
hsa05100Bacterial invasion of epithelial cellsKEGG
hsa05146AmoebiasisKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05205Proteoglycans in cancerKEGG
hsa05222Small cell lung cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000115414Heart Failure1.8449870E-004-
ENSG00000115414Platelet Function Tests4.1847400E-005-
ENSG00000115414Platelet Function Tests4.4468200E-005-
ENSG00000115414Coronary Disease7E-622319020
ENSG00000115414Cholesterol, LDL3E-824097068
ENSG00000115414Cholesterol1E-826780889
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000115414rs352339972215374248?Blood protein levels28240269[0.24-0.42] unit increase0.3258EFO_0008131
ENSG00000115414rs12502582215435462CBlood protein levels28240269[0.58-0.76] unit decrease0.6675EFO_0008131
ENSG00000115414rs12502582215435462CBlood protein levels28240269[0.21-0.41] unit decrease0.3092EFO_0008132
ENSG00000115414rs12502582215435462CBlood protein levels28240269[0.62-0.8] unit decrease0.7113EFO_0008133
ENSG00000115414rs12502592215435759ACoronary artery disease29212778[0.034-0.062] unit decrease0.048EFO_0000378
ENSG00000115414rs12502592215435759APulse pressure28135244[0.24-0.39] unit decrease0.314EFO_0005763
ENSG00000115414rs349236832215380971APulse pressure28135244[0.43-0.86] unit increase0.646EFO_0005763
ENSG00000115414rs12502582215435462?Deep ovarian and/or rectovaginal disease with dense adhesions28333195[1.14-1.35]1.2345679EFO_0001065
ENSG00000115414rs174580182215420652?Coronary heart disease22319020[NR]1.22EFO_0001645
ENSG00000115414rs12502482215422370ATotal cholesterol levels28334899[0.013-0.028] unit decrease (EA Beta values)0.0204EFO_0004574
ENSG00000115414rs12502592215435759ABlood protein levels30072576[NR] unit increase0.4210204EFO_0007937
ENSG00000115414rs12502592215435759ABlood protein levels30072576[NR] unit increase0.18947625EFO_0007937
ENSG00000115414rs12502592215435759ABlood protein levels30072576[NR] unit increase0.185187EFO_0007937
ENSG00000115414rs12502592215435759ABlood protein levels30072576[NR] unit increase0.17607602EFO_0007937
ENSG00000115414rs12502592215435759ABlood protein levels30072576[NR] unit increase0.15444492EFO_0007937
ENSG00000115414rs12502592215435759ABlood protein levels30072576[NR] unit increase0.15067199EFO_0007937
ENSG00000115414rs12502592215435759ABlood protein levels30072576[0.46-0.55] unit increase0.505EFO_0007937
ENSG00000115414rs12502482215422370?Lung function (FVC)30595370EFO_0004312
ENSG00000115414rs12502582215435462?Waist-hip ratio30595370EFO_0004343
ENSG00000115414rs12502592215435759?Systolic blood pressure30595370EFO_0006335
ENSG00000115414rs12502592215435759TPulse pressure30578418[0.32-0.52] mmHg decrease0.4236EFO_0005763
ENSG00000115414rs12502592215435759TDiastolic blood pressure30578418[0.33-0.53] mmHg increase0.4275EFO_0006336
ENSG00000115414rs12502592215435759TSystolic blood pressure30578418[0.31-0.6] mmHg decrease0.4518EFO_0006335
ENSG00000115414rs12502472215434906CSystolic blood pressure27841878unit increase0.31EFO_0006335
ENSG00000115414rs12502472215434906CPulse pressure27841878unit increase0.279EFO_0005763
ENSG00000115414rs12502472215434906CPulse pressure27841878unit increase0.268EFO_0005763
ENSG00000115414rs12502472215434906CPulse pressure27841878unit increase0.273EFO_0005763
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115414's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000115414FN110094.690ENSMUSG00000026193Fn110096.364Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001525angiogenesis-IEAProcess
GO:0001932regulation of protein phosphorylation11792823.IDAProcess
GO:0002020protease binding22952693.IPIFunction
GO:0002576platelet degranulation-TASProcess
GO:0005102signaling receptor binding17849409.IPIFunction
GO:0005178integrin binding19738201.IDAFunction
GO:0005178integrin binding24658351.IMPFunction
GO:0005178integrin binding11792823.IPIFunction
GO:0005201extracellular matrix structural constituent20551380.23979707.25037231.27559042.28327460.28344315.28675934.IEAFunction
GO:0005201extracellular matrix structural constituent-ISSFunction
GO:0005201extracellular matrix structural constituent20551380.23979707.25037231.27559042.28327460.28344315.28675934.RCAFunction
GO:0005515protein binding1400330.1747115.2531657.3141278.9269765.9278415.10627046.10788510.11773026.11956183.12225811.12421310.15165854.16336961.16457822.18042364.18160478.18243143.18323857.18411296.18713862.19220903.19542224.19738201.20080707.20541508.20875085.20879998.20979576.21569203.22442151.24136289.25034023.25290767.25293691.25416956.26627825.27616280.30082873.IPIFunction
GO:0005518collagen binding3024962.NASFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005576extracellular region14718574.NASComponent
GO:0005576extracellular region-TASComponent
GO:0005577fibrinogen complex3997886.IDAComponent
GO:0005604basement membrane-IEAComponent
GO:0005615extracellular space20551380.HDAComponent
GO:0005615extracellular space15292204.IDAComponent
GO:0005788endoplasmic reticulum lumen-TASComponent
GO:0005793endoplasmic reticulum-Golgi intermediate compartment15308636.IDAComponent
GO:0006953acute-phase response-IEAProcess
GO:0007044cell-substrate junction assembly-IEAProcess
GO:0007155cell adhesion1423622.NASProcess
GO:0007161calcium-independent cell-matrix adhesion-IEAProcess
GO:0008022protein C-terminus binding16677310.IPIFunction
GO:0008201heparin binding10075919.NASFunction
GO:0008284positive regulation of cell proliferation25834989.IDAProcess
GO:0008360regulation of cell shape-IEAProcess
GO:0009611response to wounding7989369.NASProcess
GO:0010628positive regulation of gene expression25834989.IDAProcess
GO:0010952positive regulation of peptidase activity-IEAProcess
GO:0016324apical plasma membrane-IEAComponent
GO:0016504peptidase activator activity-IEAFunction
GO:0018149peptide cross-linking3997886.IDAProcess
GO:0019221cytokine-mediated signaling pathway-TASProcess
GO:0019899enzyme binding12167537.12421310.17849409.19429745.IPIFunction
GO:0030198extracellular matrix organization-TASProcess
GO:0031012extracellular matrix26571399.IDAComponent
GO:0031093platelet alpha granule lumen-TASComponent
GO:0033622integrin activation24658351.IMPProcess
GO:0034446substrate adhesion-dependent cell spreading16236823.IDAProcess
GO:0034446substrate adhesion-dependent cell spreading24658351.IMPProcess
GO:0035987endodermal cell differentiation23154389.IDAProcess
GO:0042060wound healing-IEAProcess
GO:0042802identical protein binding17914904.18042364.18160478.19826086.19931242.20541508.IPIFunction
GO:0043394proteoglycan binding29030641.IDAFunction
GO:0043687post-translational protein modification-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0045773positive regulation of axon extension-IEAProcess
GO:0048146positive regulation of fibroblast proliferation25834989.IDAProcess
GO:0050900leukocyte migration-TASProcess
GO:0051087chaperone binding17849409.IPIFunction
GO:0051702interaction with symbiont12167537.12421310.19429745.IDAProcess
GO:0052047interaction with other organism via secreted substance involved in symbiotic interaction17849409.IDAProcess
GO:0062023collagen-containing extracellular matrix23658023.23979707.25037231.27559042.28327460.28344315.28675934.HDAComponent
GO:0062023collagen-containing extracellular matrix20551380.HDAComponent
GO:0062023collagen-containing extracellular matrix1632457.16157329.IDAComponent
GO:0062023collagen-containing extracellular matrix22261194.ISSComponent
GO:0070062extracellular exosome19056867.23533145.HDAComponent
GO:0070062extracellular exosome21276792.IDAComponent
GO:0070372regulation of ERK1 and ERK2 cascade11792823.IDAProcess
GO:0072562blood microparticle22516433.HDAComponent
GO:0097718disordered domain specific binding15292204.IPIFunction
GO:1901166neural crest cell migration involved in autonomic nervous system development26571399.IDAProcess
GO:1904237positive regulation of substrate-dependent cell migration, cell attachment to substrate25834989.IDAProcess
GO:2001202negative regulation of transforming growth factor-beta secretion25834989.IDAProcess
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