EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27769057The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer.Oncotarget2016 Nov 22Gujam FJdoi: 10.18632/oncotarget.12730.
21937453Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.J Biol Chem2011 Nov 11Barthson Jdoi: 10.1074/jbc.M111.253591
30588194Cancer/testis Antigen MAGEA3 Interacts with STAT1 and Remodels the Tumor Microenvironment.Int J Med Sci2018 Nov 22Wang Ydoi: 10.7150/ijms.27643
21571862HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.Cancer Res2011 Jul 1Stronach EAdoi: 10.1158/0008-5472.CAN-10-4111
24658320Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis.Pancreas2014 MaySun Ydoi: 10.1097/MPA.0000000000000074.
23486482Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells.J Biol Chem2013 Apr 26Hix LMdoi: 10.1074/jbc.M112.441402
30226605STAT1HDAC4 signaling induces epithelialmesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2.Oncol Rep2018 NovKaowinn Sdoi: 10.3892/or.2018.6701
29530483Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.Matrix Biol2018 SepLu Hdoi: 10.1016/j.matbio.2018.03.009
22514085Association between STAT1 activity and BRAF mutations in papillary thyroid carcinomas.J Surg Oncol2012 NovYim JHdoi: 10.1002/jso.23125
28108623Tumor-induced Stromal STAT1 Accelerates Breast Cancer via Deregulating Tissue Homeostasis.Mol Cancer Res2017 MayZellmer VRdoi: 10.1158/1541-7786.MCR-16-0312
29651441STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.J Immunol Res2018 Jan 31Chen Sdoi: 10.1155/2018/4564328
25438156Correlation of STAT1 with apoptosis and cell-cycle markers in esophageal squamous cell carcinoma.PLoS One2014 Dec 1Zhang Ydoi: 10.1371/journal.pone.0113928
17442890A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis.Mol Biol Cell2007 JulScarzello AJ-
21311224Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation.Cell Cycle2011 Mar 1Raven JF-
23920124Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling.Cancer Lett2013 Dec 1Macha MAdoi: 10.1016/j.canlet.2013.07.037
19646959STAT1 represses hypoxia-inducible factor-1-mediated transcription.Biochem Biophys Res Commun2009 Oct 2Hiroi Mdoi: 10.1016/j.bbrc.2009.07.138
19424608Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines.Int J Mol Med2009 JunShim SH-
22805310Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance.Cancer Res2012 Sep 15Zimmerman MAdoi: 10.1158/0008-5472.CAN-12-1347
16799645Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis.Oncogene2006 Dec 7Timofeeva OA-
23703473Aspirin enhances IFN-α-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway.Cancer Gene Ther2013 JunLi Tdoi: 10.1038/cgt.2013.29
23917355Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation.Int J Oncol2013 OctMalilas Wdoi: 10.3892/ijo.2013.2049
20624457STAT1 activation regulates proliferation and differentiation of renal progenitors.Cell Signal2010 NovWang Hdoi: 10.1016/j.cellsig.2010.06.012
17145596The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma.Haematologica2006 DecAlvaro T-
26081906EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.Int J Oncol2015 AugPisapia Ldoi: 10.3892/ijo.2015.3051
29079187Overexpression of eEF1A1 regulates G1-phase progression to promote HCC proliferation through the STAT1-cyclin D1 pathway.Biochem Biophys Res Commun2017 Dec 16Huang Jdoi: 10.1016/j.bbrc.2017.10.116
27486982Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings.Oncotarget2016 Sep 13Pan CMdoi: 10.18632/oncotarget.10939.
27705947MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis.Oncotarget2016 Dec 20Yang CHdoi: 10.18632/oncotarget.12401.
28981100STAT1β enhances STAT1 function by protecting STAT1α from degradation in esophageal squamous cell carcinoma.Cell Death Dis2017 Oct 5Zhang Ydoi: 10.1038/cddis.2017.481.
29715456Long noncoding RNA PVT1 inhibits interferon-α mediated therapy for hepatocellular carcinoma cells by interacting with signal transducer and activator of transcription 1.Biochem Biophys Res Commun2018 Jun 12Ding Hdoi: 10.1016/j.bbrc.2018.04.219
29800921Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGFA in human glioma cells.Biomed Pharmacother2018 AugZhang Ydoi: 10.1016/j.biopha.2018.05.079
28322462STAT1 Inhibits MiR-181a Expression to Suppress Colorectal Cancer Cell Proliferation Through PTEN/Akt.J Cell Biochem2017 OctZhang Xdoi: 10.1002/jcb.26000
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study.Breast Cancer Res Treat2014 AugSlattery MLdoi: 10.1007/s10549-014-3071-y
25686822Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer.Oncotarget2015 Mar 10Seshacharyulu P-
24825907Transcriptional regulation of oncogenic protein kinase C (PKC) by STAT1 and Sp1 proteins.J Biol Chem2014 Jul 11Wang Hdoi: 10.1074/jbc.M114.548446
23704922IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation.PLoS One2013 May 21You Wdoi: 10.1371/journal.pone.0063588
26676749Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer.Cancer Res2016 Mar 1Concha-Benavente Fdoi: 10.1158/0008-5472.CAN-15-2001
17617740Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells.Cancer Biol Ther2007 JunPapageorgiou A-
26351076STAT1 modification improves therapeutic effects of interferons on lung cancer cells.J Transl Med2015 Sep 8Chen Jdoi: 10.1186/s12967-015-0656-0.
24693969Engagement of immune effector cells by trastuzumab induces HER2/ERBB2 downregulation in cancer cells through STAT1 activation.Breast Cancer Res2014 Apr 2Shi Ydoi: 10.1186/bcr3637.
23756862Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma.Br J Cancer2013 Jul 9Gordziel Cdoi: 10.1038/bjc.2013.274
17918184EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells.Int J Cancer2008 Jan 15Andersen P-
14656722Progressive dysregulation of transcription factors NF-kappa B and STAT1 in prostate cancer cells causes proangiogenic production of CXC chemokines.Am J Physiol Cell Physiol2004 AprShen H-
22178447Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer.J Proteomics2012 Jun 6Greenwood Cdoi: 10.1016/j.jprot.2011.11.033
21321110Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines.J Biol Chem2011 Apr 8Wu Ydoi: 10.1074/jbc.M110.191031
20814891Single cell phospho-specific flow cytometry can detect dynamic changes of phospho-Stat1 level in lung cancer cells.Cytometry A2010 NovLin CCdoi: 10.1002/cyto.a.20965.
22320867Prognostic significance of phosphorylated STAT-1 expression in premenopausal and postmenopausal patients with invasive breast cancer.Histopathology2012 JunMagkou Cdoi: 10.1111/j.1365-2559.2011.04143.x
18035482Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1.Cancer Lett2008 Feb 18Sun Y-
20457620IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.Mol Cancer Ther2010 MayNing Ydoi: 10.1158/1535-7163.MCT-09-1169.
24681956B-cell lymphoma/leukemia 10 promotes oral cancer progression through STAT1/ATF4/S100P signaling pathway.Oncogene2015 Mar 5Wu TSdoi: 10.1038/onc.2014.43
26676844FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter.Oncol Rep2016 MarQian Kdoi: 10.3892/or.2015.4485
15996661STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell.FEBS Lett2005 Jul 18Jung HH-
24725474High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer.BMC Cancer2014 Apr 12Tymoszuk Pdoi: 10.1186/1471-2407-14-257.
28112370The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines.Oncol Rep2017 MarDoi Tdoi: 10.3892/or.2017.5399
27825967A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration.Biochem Biophys Res Commun2017 Jan 1Chen Xdoi: 10.1016/j.bbrc.2016.11.013
26495772Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence.Mol Carcinog2016 NovHatziieremia Sdoi: 10.1002/mc.22417
28411130IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer invivo by JAK/STAT-mediated induction of p21.Cancer Lett2017 Jul 28Lui AJdoi: 10.1016/j.canlet.2017.04.005
27213290Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation.Nat Genet2016 JulZheng Jdoi: 10.1038/ng.3568
27855602Targeting STAT1 in Both Cancer and Insulin Resistance Diseases.Curr Protein Pept Sci2017Meng Cdoi: 10.2174/1389203718666161117114735.
28273453CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.Cell Rep2017 Mar 7Qadir ASdoi: 10.1016/j.celrep.2017.02.037.
28865492Pathobiology of the 129:Stat1 -/- mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype.Breast Cancer Res2017 Sep 2Mori Hdoi: 10.1186/s13058-017-0892-8.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2191001143SilentnovelQ131Q0.29
BLCAchr2190982425Missense_MutationNAL514V0.26
BLCAchr2190982434Missense_MutationNAK511E0.46
BLCAchr2190986868Missense_MutationnovelE403K0.41
BLCAchr2190985625Silentrs73979321T419T0.26
BLCAchr2190975834Nonsense_MutationnovelE705*0.18
BLCAchr2190974874Missense_MutationNAD732H0.14
BLCAchr2190976953Missense_MutationNAR649H0.07
BLCAchr2190982425Missense_MutationnovelL514F0.13
BLCAchr2190989650SilentNAL354L0.4
BLCAchr2190979776Missense_MutationnovelD575N0.09
BLCAchr2190983650Missense_MutationnovelE480K0.41
BLCAchr2191008964Missense_MutationnovelQ91L0.78
BLCAchr2190977026Splice_SiteNAX625_splice0.33
BLCAchr2190978856Missense_MutationnovelE625K0.15
BLCAchr2190974871Missense_MutationnovelE733K0.32
BRCAchr2190978951Missense_MutationNAD593V0.37
BRCAchr2190978983SilentnovelI582I0.11
BRCAchr2190998253SilentNAL199L0.17
BRCAchr2190984322SilentnovelV445V0.09
BRCAchr2190985646Missense_MutationNAQ412H0.3
BRCAchr2190985633Missense_MutationnovelT417S0.08
BRCAchr2190975795Intronnovel0.11
BRCAchr2191009957In_Frame_InsnovelL15_E16insGL0.36
CESCchr2190987058Missense_MutationnovelE370Q0.35
CESCchr2190991230Missense_MutationNAL345F0.16
CESCchr2190975744Intronnovel0.54
CESCchr2191001105Missense_MutationnovelS144I0.28
CESCchr2191009009Missense_MutationnovelN76S0.14
CESCchr2190976940SilentNAV653V0.26
COADchr2190979798Frame_Shift_DelNAK567Nfs*250.23
COADchr2191007573Missense_MutationNAR121I0.25
COADchr21909705883'UTRnovel0.46
COADchr2190979002Splice_SiteNAX576_splice0.22
COADchr2190995184Missense_Mutationrs387906760R274Q0.05
COADchr2190975761Intronnovel0.29
COADchr2190989625Missense_MutationnovelL363V0.4
COADchr2190995140Missense_MutationnovelY289N0.38
COADchr2190980653Frame_Shift_DelnovelD534Mfs*140.24
COADchr2190997905Missense_MutationnovelA246T0.12
COADchr2190995185Missense_Mutationrs387906758R274W0.39
COADchr2190985625Silentrs73979321T419T0.25
COADchr2190986880Missense_MutationnovelS399G0.33
COADchr2190980639Missense_Mutationrs1803838P538L0.37
COADchr2190974935Splice_Regionnovel0.36
COADchr2190976953Missense_MutationNAR649H0.18
COADchr2191009027Missense_MutationNAR70H0.06
COADchr2190976938Missense_MutationnovelM654T0.13
COADchr2190979848Missense_MutationNAN551H0.19
COADchr2190999704Missense_MutationnovelC155G0.39
COADchr2191009069Missense_MutationNAR56H0.18
COADchr2190978907Missense_MutationNAR608W0.38
COADchr2190979798Frame_Shift_DelNAK567Nfs*250.16
COADchr2190975712Intronnovel0.25
COADchr21909706883'UTRnovel0.26
COADchr2190982461Silentrs777616424L502L0.39
DLBCchr2191009084Missense_MutationnovelS51L0.17
DLBCchr2191009901Missense_MutationnovelA35T0.03
ESCAchr2191009037Missense_MutationnovelQ67K0.24
ESCAchr21909706873'UTRnovel0.43
ESCAchr2191009069Missense_MutationNAR56H0.24
ESCAchr2191009005Missense_MutationNAF77L0.66
GBMchr2190970706SilentnovelV750V0.04
GBMchr2190986945Missense_MutationnovelF377C0.3
GBMchr2190998248Missense_MutationNAK201M0.31
GBMchr2190995063Missense_MutationnovelQ314H0.04
GBMchr2190978976Nonsense_MutationnovelE585*0.08
HNSCchr2190980654Splice_SitenovelX528_splice0.33
HNSCchr2191009997Nonsense_MutationnovelQ3*0.43
HNSCchr2190998279Missense_MutationnovelD191N0.11
HNSCchr2190970715Missense_MutationnovelM747I0.24
HNSCchr2191007587SilentnovelL116L0.47
HNSCchr2191008965Nonsense_MutationnovelQ91*0.88
HNSCchr2190997998Missense_MutationnovelH215Y0.07
HNSCchr2190980662Silentrs552751565N530N0.27
HNSCchr2190976880Silentrs35098579K673K0.56
HNSCchr2190978989SilentnovelG580G0.18
KIRCchr2190999673Missense_MutationNAD165A0.23
KIRPchr2191009922Frame_Shift_DelnovelM28Gfs*210.37
KIRPchr2191009079Missense_MutationnovelA53P0.24
KIRPchr2190995167Missense_MutationNAL280M0.33
LGGchr2191001140SilentnovelS132S0.41
LGGchr2190983733Missense_MutationnovelS452Y0.08
LGGchr2191010005Splice_Sitenovel0.11
LIHCchr2190976942Missense_MutationNAV653L0.55
LIHCchr2191007604Missense_MutationNAE111K0.58
LIHCchr2190989622Missense_Mutationrs759722579F364L0.36
LIHCchr2190975656Intronnovel0.42
LIHCchr2190995131Missense_MutationnovelD292H0.32
LUADchr2190991251SilentnovelG338G0.16
LUADchr2190975816Missense_MutationNAE711K0.3
LUADchr2190978942Missense_MutationNAP596L0.35
LUADchr2190976987Missense_MutationNAE638K0.23
LUADchr2190995074Nonsense_MutationnovelQ311*0.07
LUADchr2190983711In_Frame_DelnovelS459del0.29
LUADchr2191001076Missense_MutationNAM154L0.22
LUADchr2190980653SilentnovelP533P0.17
LUADchr2191009037Nonsense_MutationNAQ67*0.29
LUADchr2190991284SilentNAT327T0.46
LUADchr2191007595Missense_MutationnovelK114E0.12
LUADchr2190997974Missense_MutationnovelV223I0.14
LUSCchr2191009889Missense_MutationnovelE39Q0.26
LUSCchr2191009955Missense_MutationnovelQ17E0.2
LUSCchr2190975752Intronnovel0.23
LUSCchr2190976930Missense_MutationnovelE657K0.27
LUSCchr2190982461Silentrs777616424L502L0.08
LUSCchr2191010004Splice_Regionnovel0.25
LUSCchr2190980652Missense_MutationNAD534N0.18
LUSCchr2190976999Frame_Shift_DelnovelD627Tfs*310.13
LUSCchr2190997960SilentNAT227T0.19
LUSCchr2190983701Missense_MutationNAQ463E0.06
LUSCchr2190986873Missense_MutationnovelA401V0.37
LUSCchr2190989630In_Frame_InsnovelR346_V360dup0.57
MESOchr2190997896Missense_MutationnovelG249R0.21
OVchr21909706673'UTRnovel0.04
OVchr2190982437Missense_MutationnovelT510P0.17
OVchr2190997890Frame_Shift_InsnovelP251Afs*280.05
OVchr2190974868Missense_MutationNAV734L0.17
OVchr2191009101Silentrs566696388H45H0.1
PAADchr2190982484Missense_Mutationrs770809861R494Q0.09
PAADchr2190975862SilentNAG695G0.21
PAADchr2190985638Missense_MutationnovelA415D0.26
PRADchr2190997992Missense_MutationNAI217L0.36
READchr21909705823'UTRnovel0.21
READchr2190995204SilentnovelA267A0.03
READchr2190998255Missense_MutationnovelL199V0.09
READchr2190978999Missense_MutationNAC577Y0.44
READchr2191009065Missense_MutationNAF57L0.24
READchr2190998227Missense_MutationNAN208S0.24
READchr2191009005Missense_MutationNAF77L0.5
SARCchr2190983739Missense_Mutationrs527393923T450M0.36
SARCchr2190980640Missense_MutationNAP538S0.17
SKCMchr2190998303Missense_MutationnovelE183K0.42
SKCMchr2190983674Missense_MutationnovelL472F0.19
SKCMchr2190983675SilentnovelI471I0.19
SKCMchr2191009925Missense_MutationNAP27S0.05
SKCMchr2191007623SilentNAI104I0.3
SKCMchr2190986891Missense_MutationNAS395F0.38
SKCMchr2190980640Missense_MutationNAP538S0.36
SKCMchr2190978994Missense_MutationNAM579L0.5
SKCMchr2191009875Splice_SitenovelX43_splice0.17
SKCMchr2191009876Nonsense_MutationnovelW43*0.17
SKCMchr2190979807Silentrs760830783L564L0.45
SKCMchr2191009919Missense_MutationNAE29Q0.39
STADchr2191008975Missense_MutationNAK87N0.23
STADchr2190976958SilentnovelI647I0.09
STADchr2190983725Missense_Mutationrs371982540V455I0.28
STADchr2190985626Missense_MutationNAT419M0.61
STADchr2190986852Splice_SiteNAX407_splice0.07
STADchr2190998299Missense_MutationNAT184I0.18
STADchr2190995183SilentnovelR274R0.22
STADchr2190978904Missense_MutationNAE609K0.13
STADchr2190986921Missense_Mutationrs587777630T385M0.24
STADchr2190983659SilentNAL477L0.14
STADchr2190995115Frame_Shift_DelnovelN297Tfs*390.24
STADchr2190999667Missense_MutationNAQ167R0.56
STADchr2191009988Missense_Mutationrs761876441E6K0.22
TGCTchr2190978898Missense_MutationnovelA611T0.25
THYMchr2191010372Intronnovel0.11
UCECchr2190989626SilentNAV362V0.27
UCECchr2190995137Missense_Mutationrs750476767E290K0.4
UCECchr2190977009Silentrs757407974A630A0.45
UCECchr21909705823'UTRnovel0.32
UCECchr2190997970Missense_MutationnovelT224I0.41
UCECchr2190979781Missense_MutationnovelW573L0.35
UCECchr21909704793'UTRnovel0.44
UCECchr2190976953Missense_MutationNAR649H0.42
UCECchr2190998304SilentnovelH182H0.31
UCECchr2190979849Missense_MutationNAK550N0.23
UCECchr2190999682Missense_MutationNAS162I0.11
UCECchr2190997920Missense_MutationNAR241W0.38
UCECchr2191009028Missense_MutationnovelR70C0.38
UCECchr2190976954Missense_MutationNAR649C0.2
UCECchr2190982425Missense_MutationnovelL514I0.07
UCECchr2191007577Nonsense_MutationnovelQ120*0.19
UCECchr2190978857Splice_Regionrs2230101G624G0.29
UCECchr2190984381Missense_Mutationrs143182587V426I0.34
UCECchr2190986861Missense_MutationNAR405Q0.29
UCECchr2190983643Missense_MutationNAR482M0.33
UCECchr2190975734Intronnovel0.23
UCECchr2190977010Missense_MutationNAA630V0.3
UCECchr2191007620Missense_MutationnovelI105M0.18
UCECchr2190980661Missense_Mutationrs148573907A531T0.41
UCECchr2190975794Intronnovel0.1
UCECchr2190979774Missense_MutationNAD575E0.37
UCECchr2190991272SilentnovelR331R0.4
UCECchr2190982515SilentNAL484L0.33
UCECchr2190976987Nonsense_MutationNAE638*0.36
UCECchr2190999662Nonsense_MutationnovelE169*0.47
UCECchr2190976869Missense_MutationnovelF677S0.2
UCECchr2190980639Missense_Mutationrs1803838P538L0.5
UCECchr2190997950SilentnovelL231L0.56
UCECchr2190983669Nonsense_MutationnovelW473*0.18
UCECchr2190975702Intronnovel0.43
UCECchr2191010380Intronnovel0.32
UCECchr2190978863Silentrs112108750N622N0.3
UCECchr2190974838Missense_Mutationrs780156389D744N0.44
UCECchr2190977010Missense_MutationNAA630V0.39
UCECchr2190997905Missense_MutationnovelA246T0.5
UCECchr2190998008Splice_SitenovelX212_splice0.21
UCECchr2191009100Missense_MutationnovelA46T0.27
UCECchr2191009988Missense_Mutationrs761876441E6K0.24
UCECchr2191009069Missense_MutationNAR56H0.43
UCECchr2190979798Frame_Shift_DelNAK567Nfs*250.27
UCECchr2190976984Missense_MutationNAL639I0.45
UCECchr2191009021Missense_MutationNAS72Y0.25
UCECchr2190997857Missense_MutationnovelW262G0.28
UCECchr2190975840Missense_MutationnovelK703E0.25
UCECchr2191007560Splice_RegionNA0.2
UCECchr2190977010Missense_MutationNAA630V0.44
UCECchr2190998243Missense_MutationnovelY203H0.34
UCECchr2190975841SilentnovelI702I0.3
UCSchr2190983708Missense_MutationnovelN460K0.13
UCSchr2190979789SilentnovelL570L0.14

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.13560.012962
PAADAMP0.06520.1091
PAADDEL0.03260.2014

Survival Analysis
CancerP-value Q-value
THYM0.042

Kaplan-Meier Survival Analysis

SARC0.002

Kaplan-Meier Survival Analysis

MESO0.039

Kaplan-Meier Survival Analysis

ACC0.00093

Kaplan-Meier Survival Analysis

SKCM0.00013

Kaplan-Meier Survival Analysis

KIRP0.0009

Kaplan-Meier Survival Analysis

PAAD0.00014

Kaplan-Meier Survival Analysis

UCEC0.027

Kaplan-Meier Survival Analysis

CHOL0.042

Kaplan-Meier Survival Analysis

THCA0.004

Kaplan-Meier Survival Analysis

LUAD0.02

Kaplan-Meier Survival Analysis

UVM0.018

Kaplan-Meier Survival Analysis

OV0.00025

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000115415 (Gene tree)
Gene ID
6772
Gene Symbol
STAT1
Alias
STAT91|ISGF-3
Full Name
signal transducer and activator of transcription 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
56,603 bases
Position
chr2:190,964,358-191,020,960
Accession
11362
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28767039FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion.Elife2017 Aug 2Fan Ydoi: 10.7554/eLife.26129.
16428770Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting.Infect Immun2006 FebZhou Q-
17032459Proximal genomic localization of STAT1 binding and regulated transcriptional activity.BMC Genomics2006 Oct 11Wormald S-
213079419p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response.Nature2011 Feb 10Harismendy Odoi: 10.1038/nature09753.
21325029pp32, an INHAT component, is a transcription machinery recruiter for maximal induction of IFN-stimulated genes.J Cell Sci2011 Mar 15Kadota Sdoi: 10.1242/jcs.078253
30574148The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment.Front Immunol2018 Dec 6Parrini Mdoi: 10.3389/fimmu.2018.02879
9485044Human malignant mesothelioma cell growth: activation of janus kinase 2 and signal transducer and activator of transcription 1alpha for inhibition by interferon-gamma.Cancer Res1998 Feb 15Buard A-
7595221Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma.J Exp Med1995 Nov 1Lu HT-
11207308Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway.J Immunol2001 Mar 1Li WQ-
18417573Henipavirus V protein association with Polo-like kinase reveals functional overlap with STAT1 binding and interferon evasion.J Virol2008 JulLudlow LEdoi: 10.1128/JVI.00409-08
17726060P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma.J Cell Sci2007 Sep 15Christova R-
17179173Inhibition of interleukin 1-induced matrix metalloproteinase 13 expression in human chondrocytes by interferon gamma.Ann Rheum Dis2007 JunAhmad R-
22022391PCBP2 enhances the antiviral activity of IFN-α against HCV by stabilizing the mRNA of STAT1 and STAT2.PLoS One2011Xin Zdoi: 10.1371/journal.pone.0025419
21115099PML positively regulates interferon gamma signaling.Biochimie2011 MarEl Bougrini Jdoi: 10.1016/j.biochi.2010.11.005
26686630Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.Cell Rep2015 Dec 22Rupaimoole Rdoi: 10.1016/j.celrep.2015.11.047
26146080Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-kB Pathways by Concerted Recruitment of the Mediator Complex.Cell Rep2015 Jul 14Wienerroither Sdoi: 10.1016/j.celrep.2015.06.021
26061044The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways.DNA Cell Biol2015 AugHernandez JMdoi: 10.1089/dna.2014.2730
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000432058STAT1-208567-ENSP0000041601969 (aa)-E9PH66
ENST00000452281STAT1-2092594-ENSP00000394512193 (aa)-D2KFR9
ENST00000415035STAT1-205663-ENSP0000038824040 (aa)-H7BZ88
ENST00000424722STAT1-207736-ENSP00000402548180 (aa)-E7EPD2
ENST00000409465STAT1-2043097-ENSP00000386244750 (aa)-P42224
ENST00000540176STAT1-2124216-ENSP00000438703193 (aa)-D2KFR9
ENST00000423282STAT1-206477-ENSP0000038877258 (aa)-H7BZB5
ENST00000454414STAT1-210572-ENSP00000411398150 (aa)-E7ENM1
ENST00000464072STAT1-211865--- (aa)--
ENST00000392323STAT1-2032723-ENSP00000376137714 (aa)-J3KPM9
ENST00000392322STAT1-2022716-ENSP00000376136712 (aa)-P42224
ENST00000361099STAT1-2014310XM_006712718ENSP00000354394750 (aa)XP_006712781P42224
Gene Model
Click here to download ENSG00000115415's gene model file
Pathways
Pathway IDPathway NameSource
hsa04062Chemokine signaling pathwayKEGG
hsa04217NecroptosisKEGG
hsa04380Osteoclast differentiationKEGG
hsa04620Toll-like receptor signaling pathwayKEGG
hsa04621NOD-like receptor signaling pathwayKEGG
hsa04625C-type lectin receptor signaling pathwayKEGG
hsa04630JAK-STAT signaling pathwayKEGG
hsa04658Th1 and Th2 cell differentiationKEGG
hsa04659Th17 cell differentiationKEGG
hsa04917Prolactin signaling pathwayKEGG
hsa04919Thyroid hormone signaling pathwayKEGG
hsa04933AGE-RAGE signaling pathway in diabetic complicationsKEGG
hsa05140LeishmaniasisKEGG
hsa05145ToxoplasmosisKEGG
hsa05152TuberculosisKEGG
hsa05160Hepatitis CKEGG
hsa05161Hepatitis BKEGG
hsa05162MeaslesKEGG
hsa05164Influenza AKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05167Kaposi sarcoma-associated herpesvirus infectionKEGG
hsa05168Herpes simplex virus 1 infectionKEGG
hsa05169Epstein-Barr virus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05212Pancreatic cancerKEGG
hsa05321Inflammatory bowel disease (IBD)KEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000115415Interleukin 1 Receptor Antagonist Protein4.7680000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000115415rs124685792190967538?JT interval (sulfonylurea treatment interaction)27958378[2.53-5.67] ms increase4.1EFO_0007885|EFO_0007922
ENSG00000115415rs455397322191009521?Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular)236037611.53EFO_1001999|EFO_1002020|EFO_1002019
ENSG00000115415rs609769902190991701TNeutrophil percentage of granulocytes27863252[0.03-0.06] unit increase0.04537308EFO_0007994
ENSG00000115415rs75652372190971964?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115415's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000115415STAT110062.319ENSG00000168610STAT310061.905Homo_sapiens
ENSG00000115415STAT110062.319ENSMUSG00000004040Stat39953.556Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-ISSProcess
GO:0000790nuclear chromatin18035482.IDAComponent
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding18035482.21268089.IDAFunction
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding23386060.28753426.IDAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific21268089.IDAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.ISMFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.NASFunction
GO:0001937negative regulation of endothelial cell proliferation16585190.IMPProcess
GO:0002053positive regulation of mesenchymal cell proliferation-ISSProcess
GO:0002230positive regulation of defense response to virus by host26479788.IGIProcess
GO:0002230positive regulation of defense response to virus by host26479788.IMPProcess
GO:0003340negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis-ISSProcess
GO:0003690double-stranded DNA binding9630226.IDAFunction
GO:0003700DNA-binding transcription factor activity10973496.23386060.IDAFunction
GO:0005164tumor necrosis factor receptor binding10848577.IPIFunction
GO:0005515protein binding8156998.8605877.8662591.9121453.9881977.10848577.11238845.12070153.12788789.12867595.15780933.15825084.16189514.16273093.16306601.16531398.16940534.17275127.17923090.20195357.21903422.21988832.24065129.24360797.24658140.25241761.25416956.25609649.26479788.26504087.26889034.26966684.28753426.IPIFunction
GO:0005634nucleus10692450.10973496.15825084.16306601.21268089.23386060.28753426.IDAComponent
GO:0005634nucleus26479788.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm10692450.10973496.15825084.17275127.23386060.26479788.27796300.28753426.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0007221positive regulation of transcription of Notch receptor target-TASProcess
GO:0007259JAK-STAT cascade22002246.IDAProcess
GO:0007584response to nutrient-IEAProcess
GO:0008015blood circulation-ISSProcess
GO:0009612response to mechanical stimulus-IEAProcess
GO:0010742macrophage derived foam cell differentiation26504087.IDAProcess
GO:0016032viral process-IEAProcess
GO:0016525negative regulation of angiogenesis16585190.IMPProcess
GO:0019221cytokine-mediated signaling pathway-TASProcess
GO:0019899enzyme binding22002246.26479788.IPIFunction
GO:0030424axon-ISSComponent
GO:0030425dendrite-ISSComponent
GO:0031730CCR5 chemokine receptor binding-IEAFunction
GO:0032727positive regulation of interferon-alpha production28753426.IDAProcess
GO:0032869cellular response to insulin stimulus-IEAProcess
GO:0032991protein-containing complex26479788.IDAComponent
GO:0033209tumor necrosis factor-mediated signaling pathway10848577.IDAProcess
GO:0034097response to cytokine-ISSProcess
GO:0035035histone acetyltransferase binding26479788.IPIFunction
GO:0035257nuclear hormone receptor binding26504087.IPIFunction
GO:0035456response to interferon-beta24882218.IMPProcess
GO:0035458cellular response to interferon-beta18035482.IMPProcess
GO:0038113interleukin-9-mediated signaling pathway-TASProcess
GO:0038114interleukin-21-mediated signaling pathway-TASProcess
GO:0042393histone binding26479788.IPIFunction
GO:0042542response to hydrogen peroxide-IEAProcess
GO:0042802identical protein binding8605877.9630226.IPIFunction
GO:0042803protein homodimerization activity9630226.28753426.IDAFunction
GO:0042981regulation of apoptotic process12108949.TASProcess
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling10848577.IMPProcess
GO:0043434response to peptide hormone-ISSProcess
GO:0043542endothelial cell migration16585190.IMPProcess
GO:0044389ubiquitin-like protein ligase binding26479788.IPIFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0045648positive regulation of erythrocyte differentiation28283061.IMPProcess
GO:0045893positive regulation of transcription, DNA-templated10973496.IDAProcess
GO:0045893positive regulation of transcription, DNA-templated26479788.IGIProcess
GO:0045893positive regulation of transcription, DNA-templated26479788.IMPProcess
GO:0045944positive regulation of transcription by RNA polymerase II18035482.IMPProcess
GO:0046725negative regulation by virus of viral protein levels in host cell15825084.IMPProcess
GO:0048471perinuclear region of cytoplasm17275127.IDAComponent
GO:0048661positive regulation of smooth muscle cell proliferation-ISSProcess
GO:0051591response to cAMP-ISSProcess
GO:0051607defense response to virus28753426.IDAProcess
GO:0051721protein phosphatase 2A binding-IEAFunction
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process-IEAProcess
GO:0060333interferon-gamma-mediated signaling pathway21268089.IDAProcess
GO:0060333interferon-gamma-mediated signaling pathway26479788.IMPProcess
GO:0060333interferon-gamma-mediated signaling pathway-ISSProcess
GO:0060333interferon-gamma-mediated signaling pathway-TASProcess
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TASProcess
GO:0060337type I interferon signaling pathway23386060.IDAProcess
GO:0060337type I interferon signaling pathway-ISSProcess
GO:0060337type I interferon signaling pathway-TASProcess
GO:0061326renal tubule development20861313.IMPProcess
GO:0070102interleukin-6-mediated signaling pathway-TASProcess
GO:0070106interleukin-27-mediated signaling pathway-TASProcess
GO:0070491repressing transcription factor binding23386060.IPIFunction
GO:0070757interleukin-35-mediated signaling pathway-TASProcess
GO:0071346cellular response to interferon-gamma23386060.IDAProcess
GO:0071407cellular response to organic cyclic compound-IEAProcess
GO:0072136metanephric mesenchymal cell proliferation involved in metanephros development-ISSProcess
GO:0072162metanephric mesenchymal cell differentiation-ISSProcess
GO:0072308negative regulation of metanephric nephron tubule epithelial cell differentiation-ISSProcess
GO:1990841promoter-specific chromatin binding26479788.IDAFunction
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