EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25768983	Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers.	PLoS Comput Biol	2015 Mar 13	DeBoever C	doi: 10.1371/journal.pcbi.1004105
27123562	Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.	JAMA Ophthalmol	2016 Jul 1	Decatur CL	doi: 10.1001/jamaophthalmol.2016.0903.
27916271	Correlation of Gene Mutation Status with Copy Number Profile in Uveal Melanoma.	Ophthalmology	2017 Apr	Yavuzyigitoglu S	doi: 10.1016/j.ophtha.2016.10.039
22496461	SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression.	Mol Cancer Res	2012 Jun	Matsushita K	doi: 10.1158/1541-7786.MCR-11-0462
28615231	Single-Nucleotide Polymorphism Leading to False Allelic Fraction by Droplet Digital PCR.	Clin Chem	2017 Aug	Christenson ES	doi: 10.1373/clinchem.2017.273177
27720643	Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.	Mol Cell	2016 Oct 20	Cretu C	doi: 10.1016/j.molcel.2016.08.036
28177281	Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.	Elife	2017 Feb 8	Paolella BR	doi: 10.7554/eLife.23268.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr2	197393036	Missense_Mutation	novel	M1231T	0.35
ACC	chr2	197416857	Missense_Mutation	novel	V184F	0.58
BLCA	chr2	197400729	Missense_Mutation	NA	E902K	0.34
BLCA	chr2	197400729	Missense_Mutation	NA	E902K	0.64
BLCA	chr2	197392994	Missense_Mutation	NA	R1245T	0.14
BLCA	chr2	197396105	Missense_Mutation	novel	D1164Y	0.1
BLCA	chr2	197400729	Missense_Mutation	NA	E902K	0.25
BLCA	chr2	197418914	Intron	novel		0.43
BLCA	chr2	197400729	Missense_Mutation	NA	E902K	0.34
BLCA	chr2	197401989	Missense_Mutation	rs776846119	G740E	0.36
BLCA	chr2	197435026	5'UTR	novel		0.26
BLCA	chr2	197416791	Missense_Mutation	novel	Q206E	0.05
BLCA	chr2	197393083	Silent	rs759035215	V1215V	0.3
BLCA	chr2	197409911	Missense_Mutation	NA	D255N	0.16
BLCA	chr2	197402130	Missense_Mutation	novel	G693D	0.34
BLCA	chr2	197400855	Missense_Mutation	NA	E860K	0.35
BLCA	chr2	197416814	Missense_Mutation	novel	R198Q	0.2
BLCA	chr2	197416853	Missense_Mutation	NA	N185S	0.38
BLCA	chr2	197400725	Missense_Mutation	novel	Q903P	0.1
BLCA	chr2	197416881	Missense_Mutation	NA	A176T	0.3
BLCA	chr2	197398510	Missense_Mutation	NA	E1029K	0.17
BLCA	chr2	197400728	Missense_Mutation	novel	E902G	0.53
BLCA	chr2	197400729	Missense_Mutation	NA	E902K	0.33
BLCA	chr2	197435010	5'UTR	novel		0.26
BLCA	chr2	197400729	Missense_Mutation	NA	E902K	0.45
BLCA	chr2	197400849	Missense_Mutation	NA	E862K	0.13
BLCA	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.39
BLCA	chr2	197402113	Missense_Mutation	novel	Q699E	0.76
BRCA	chr2	197402635	Missense_Mutation	rs377023736	K666N	0.15
BRCA	chr2	197392145	3'UTR	novel		0.08
BRCA	chr2	197409786	Silent	novel	T296T	0.03
BRCA	chr2	197418866	Intron	novel		0.18
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.36
BRCA	chr2	197402637	Missense_Mutation	NA	K666E	0.29
BRCA	chr2	197409953	Nonsense_Mutation	NA	G241*	0.11
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.44
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.15
BRCA	chr2	197398076	Missense_Mutation	novel	C1059R	0.09
BRCA	chr2	197402769	Missense_Mutation	NA	E622Q	0.36
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.29
BRCA	chr2	197402757	Missense_Mutation	rs769888451	N626D	0.26
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.65
BRCA	chr2	197402735	Missense_Mutation	NA	A633V	0.55
BRCA	chr2	197416774	In_Frame_Del	novel	A210_T211del	0.06
BRCA	chr2	197401492	Missense_Mutation	novel	E802Q	0.04
BRCA	chr2	197401818	Missense_Mutation	novel	Y765C	0.24
BRCA	chr2	197405322	Missense_Mutation	NA	L464F	0.33
BRCA	chr2	197420525	Silent	rs778514440	E106E	0.14
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.14
BRCA	chr2	197419052	Intron	novel		0.71
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.4
BRCA	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.23
CESC	chr2	197402637	Missense_Mutation	NA	K666E	0.26
CESC	chr2	197403621	Silent	novel	Y561Y	0.17
CESC	chr2	197405304	Missense_Mutation	novel	D470N	0.24
CESC	chr2	197396082	Silent	novel	P1171P	0.59
CESC	chr2	197435005	5'UTR	novel		0.43
CHOL	chr2	197401989	Missense_Mutation	rs776846119	G740E	0.31
CHOL	chr2	197423898	Silent	novel	S35S	0.49
COAD	chr2	197392414	Missense_Mutation	NA	I1268M	0.39
COAD	chr2	197418901	Intron	rs755141711		0.35
COAD	chr2	197420274	Intron	novel		0.3
COAD	chr2	197405438	Missense_Mutation	NA	R425Q	0.06	SF3b1
COAD	chr2	197419067	Intron	novel		0.52
COAD	chr2	197398518	Missense_Mutation	novel	N1026S	0.27
COAD	chr2	197409901	Missense_Mutation	novel	P258L	0.39
COAD	chr2	197408564	Missense_Mutation	NA	S308R	0.18
COAD	chr2	197400385	Missense_Mutation	novel	K923R	0.4
COAD	chr2	197398027	Missense_Mutation	NA	R1075K	0.37
COAD	chr2	197409825	Silent	rs747909166	G283G	0.09
COAD	chr2	197402029	Missense_Mutation	novel	V727L	0.39
COAD	chr2	197400388	Missense_Mutation	NA	G922D	0.35
COAD	chr2	197403015	Silent	rs566175207	P580P	0.33
COAD	chr2	197393153	Missense_Mutation	novel	V1192A	0.18
COAD	chr2	197420192	Intron	novel		0.91
COAD	chr2	197420351	Intron	NA		0.24
COAD	chr2	197402085	Missense_Mutation	NA	A708V	0.23
COAD	chr2	197408048	Missense_Mutation	NA	R397C	0.31	SF3b1
COAD	chr2	197402044	Missense_Mutation	NA	E722K	0.09
COAD	chr2	197418975	Intron	rs757668676		0.2
COAD	chr2	197416811	Missense_Mutation	NA	R199H	0.32
COAD	chr2	197393153	Missense_Mutation	novel	V1192A	0.06
COAD	chr2	197398496	Missense_Mutation	novel	E1033D	0.05
COAD	chr2	197393145	Missense_Mutation	novel	M1195V	0.29
COAD	chr2	197398032	Missense_Mutation	NA	I1073M	0.31
COAD	chr2	197405438	Missense_Mutation	NA	R425Q	0.27	SF3b1
COAD	chr2	197435040	5'UTR	novel		0.2
COAD	chr2	197401451	Frame_Shift_Del	NA	*F815Lfs19**	0.14
COAD	chr2	197423957	Missense_Mutation	NA	R16G	0.66
COAD	chr2	197423857	Missense_Mutation	novel	S49I	0.23
ESCA	chr2	197403652	Nonsense_Mutation	novel	L551*	0.12
ESCA	chr2	197392348	Silent	novel	D1290D	0.34
ESCA	chr2	197396258	Missense_Mutation	novel	T1113A	0.34
ESCA	chr2	197392084	3'UTR	novel		0.23
GBM	chr2	197402974	Missense_Mutation	NA	R594Q	0.09
GBM	chr2	197400849	Missense_Mutation	NA	E862K	0.23
GBM	chr2	197400285	Silent	novel	S956S	0.47
GBM	chr2	197401804	Missense_Mutation	novel	M770V	0.05
GBM	chr2	197398514	Frame_Shift_Ins	novel	*R1027Sfs3**	0.04
HNSC	chr2	197398547	Silent	novel	L1016L	0.29
HNSC	chr2	197396117	Missense_Mutation	novel	E1160K	0.07
HNSC	chr2	197420480	Silent	NA	K121K	0.32
HNSC	chr2	197409817	Missense_Mutation	novel	S286C	0.14
HNSC	chr2	197434991	Silent	novel	K3K	0.06
HNSC	chr2	197420541	Missense_Mutation	novel	Y101C	0.62
HNSC	chr2	197408043	Silent	novel	P398P	0.29
KIRC	chr2	197401987	Missense_Mutation	NA	K741E	0.37
KIRC	chr2	197408380	Missense_Mutation	novel	T369N	0.13	SF3b1
KIRC	chr2	197401887	Missense_Mutation	rs755415626	G742D	0.2
KIRC	chr2	197393108	Missense_Mutation	NA	S1207L	0.18
KIRP	chr2	197405330	Missense_Mutation	novel	S461Y	0.44
KIRP	chr2	197420485	Missense_Mutation	NA	K120Q	0.04
KIRP	chr2	197400893	Missense_Mutation	NA	A847V	0.14
KIRP	chr2	197400407	Missense_Mutation	NA	T916A	0.46
KIRP	chr2	197396090	Missense_Mutation	NA	V1169I	0.4
KIRP	chr2	197408028	Silent	novel	E403E	0.24
KIRP	chr2	197409874	Missense_Mutation	NA	T267N	0.35
LAML	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.51
LAML	chr2	197400934	Splice_Site	novel	X833_splice	0.12
LAML	chr2	197396146	Missense_Mutation	novel	S1150L	0.05
LGG	chr2	197401404	Missense_Mutation	NA	R831Q	0.06
LGG	chr2	197400929	Missense_Mutation	novel	D835V	0.38
LGG	chr2	197402983	Missense_Mutation	NA	V591E	0.27
LGG	chr2	197400347	Missense_Mutation	novel	V936I	0.44
LGG	chr2	197401454	Missense_Mutation	novel	F814L	0.11
LGG	chr2	197408540	Missense_Mutation	novel	T316A	0.13
LGG	chr2	197408517	Silent	NA	I323I	0.29
LGG	chr2	197402640	Missense_Mutation	NA	I665F	0.16
LIHC	chr2	197401987	Missense_Mutation	NA	K741Q	0.36
LIHC	chr2	197408524	Missense_Mutation	novel	D321V	0.45
LIHC	chr2	197403028	Missense_Mutation	NA	V576A	0.26
LIHC	chr2	197402757	Missense_Mutation	NA	N626H	0.11
LIHC	chr2	197402636	Missense_Mutation	rs374250186	K666T	0.47
LIHC	chr2	197402076	Missense_Mutation	novel	A711V	0.45
LIHC	chr2	197409845	Missense_Mutation	novel	A277S	0.39
LIHC	chr2	197396183	Missense_Mutation	novel	V1138L	0.37
LIHC	chr2	197401985	Missense_Mutation	NA	K741N	0.19
LUAD	chr2	197420472	Missense_Mutation	novel	R124L	0.11
LUAD	chr2	197401985	Missense_Mutation	NA	K741N	0.38
LUAD	chr2	197408397	Silent	novel	P363P	0.09
LUAD	chr2	197401989	Missense_Mutation	rs776846119	G740E	0.19
LUAD	chr2	197416876	Missense_Mutation	novel	K177N	0.05
LUAD	chr2	197401788	Missense_Mutation	NA	R775L	0.1
LUAD	chr2	197421072	Missense_Mutation	novel	A86V	0.07
LUAD	chr2	197402757	Missense_Mutation	NA	N626Y	0.29
LUAD	chr2	197408412	Silent	novel	T358T	0.21
LUAD	chr2	197401989	Missense_Mutation	NA	G740V	0.26
LUAD	chr2	197409799	Missense_Mutation	NA	R292K	0.07
LUAD	chr2	197392447	Silent	novel	P1257P	0.11
LUAD	chr2	197416790	Missense_Mutation	NA	Q206R	0.39
LUAD	chr2	197409979	Nonsense_Mutation	novel	W232*	0.3
LUAD	chr2	197400816	Missense_Mutation	novel	E873Q	0.15
LUAD	chr2	197416912	Splice_Site	novel	X166_splice	0.19
LUAD	chr2	197409963	Silent	NA	G237G	0.21
LUAD	chr2	197396057	Splice_Region	novel	R1180R	0.23
LUAD	chr2	197400277	Missense_Mutation	NA	A959V	0.29
LUSC	chr2	197392219	3'UTR	novel		0.24
LUSC	chr2	197420510	Missense_Mutation	novel	K111N	0.28
LUSC	chr2	197408555	Missense_Mutation	novel	A311T	0.06
LUSC	chr2	197420459	Silent	novel	I128I	0.1
LUSC	chr2	197400260	Missense_Mutation	novel	C965S	0.28
LUSC	chr2	197421073	Missense_Mutation	NA	A86T	0.34
LUSC	chr2	197408519	Missense_Mutation	rs587778679	I323V	0.07
LUSC	chr2	197420315	Intron	novel		0.29
LUSC	chr2	197398501	Nonsense_Mutation	novel	Q1032*	0.32
LUSC	chr2	197398112	Missense_Mutation	NA	A1047S	0.28
LUSC	chr2	197421111	Missense_Mutation	novel	S73F	0.24
LUSC	chr2	197423957	Nonsense_Mutation	NA	R16*	0.2
LUSC	chr2	197401818	Missense_Mutation	novel	Y765C	0.21
LUSC	chr2	197402992	Missense_Mutation	novel	Y588C	0.3
LUSC	chr2	197403692	Silent	rs377652778	L538L	0.49
LUSC	chr2	197400725	Missense_Mutation	NA	Q903R	0.18
LUSC	chr2	197398540	Missense_Mutation	novel	R1019G	0.06
MESO	chr2	197401887	Missense_Mutation	rs755415626	G742D	0.27
OV	chr2	197398473	Missense_Mutation	NA	R1041H	0.06
OV	chr2	197418523	Missense_Mutation	novel	L161M	0.18
OV	chr2	197393095	Silent	NA	L1211L	0.33
PAAD	chr2	197401824	Missense_Mutation	NA	N763S	0.34
PAAD	chr2	197400905	Missense_Mutation	novel	K843R	0.23
PAAD	chr2	197401989	Missense_Mutation	rs776846119	G740E	0.24
PAAD	chr2	197402635	Missense_Mutation	rs377023736	K666N	0.03
PAAD	chr2	197420290	Intron	novel		0.25
PRAD	chr2	197400855	Missense_Mutation	NA	E860K	0.17
PRAD	chr2	197403015	Silent	rs566175207	P580P	0.46
PRAD	chr2	197401987	Missense_Mutation	NA	K741E	0.3
PRAD	chr2	197402767	Missense_Mutation	rs763149798	E622D	0.13
PRAD	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.48
READ	chr2	197408542	Missense_Mutation	NA	R315Q	0.25
READ	chr2	197419035	Intron	novel		0.33
READ	chr2	197423903	Missense_Mutation	NA	D34N	0.21
READ	chr2	197420196	Intron	novel		0.56
SARC	chr2	197401876	Missense_Mutation	novel	F746V	0.09
SARC	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.42
SKCM	chr2	197401462	Missense_Mutation	NA	P812S	0.29
SKCM	chr2	197402759	Missense_Mutation	NA	R625H	0.23
SKCM	chr2	197400741	Missense_Mutation	NA	Y898H	0.23
SKCM	chr2	197401796	Silent	NA	I772I	0.12
SKCM	chr2	197409988	Missense_Mutation	NA	S229F	0.27
SKCM	chr2	197392398	Missense_Mutation	NA	I1274F	0.09
SKCM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.1
SKCM	chr2	197403612	Missense_Mutation	novel	D564E	0.61
SKCM	chr2	197402759	Missense_Mutation	NA	R625H	0.46
SKCM	chr2	197409853	Missense_Mutation	NA	P274L	0.3
SKCM	chr2	197402757	Missense_Mutation	NA	N626Y	0.28
SKCM	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.3
SKCM	chr2	197423904	Silent	rs143444124	L33L	0.31
SKCM	chr2	197402759	Missense_Mutation	NA	R625H	0.43
SKCM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.18
SKCM	chr2	197408377	Missense_Mutation	NA	P370L	0.29	SF3b1
SKCM	chr2	197409992	Missense_Mutation	NA	P228S	0.39
SKCM	chr2	197434986	Missense_Mutation	novel	A5V	0.06
SKCM	chr2	197400752	Missense_Mutation	NA	D894G	0.32
SKCM	chr2	197405439	Nonsense_Mutation	novel	R425*	0.56	SF3b1
SKCM	chr2	197408434	Missense_Mutation	novel	P351L	0.27	SF3b1
SKCM	chr2	197408435	Missense_Mutation	novel	P351S	0.28	SF3b1
SKCM	chr2	197402759	Missense_Mutation	NA	R625H	0.7
SKCM	chr2	197405319	Missense_Mutation	NA	P465S	0.12
SKCM	chr2	197400161	Silent	NA	K969K	0.28
SKCM	chr2	197420440	Missense_Mutation	NA	P135S	0.09
SKCM	chr2	197392329	Missense_Mutation	rs267599149	R1297C	0.41
SKCM	chr2	197408498	Nonsense_Mutation	NA	G330*	0.36	SF3b1
SKCM	chr2	197392452	Missense_Mutation	NA	H1256Y	0.5
SKCM	chr2	197405380	Silent	novel	F444F	0.35
SKCM	chr2	197420515	Missense_Mutation	NA	P110S	0.12
STAD	chr2	197393092	Silent	novel	L1212L	0.26
STAD	chr2	197396090	Missense_Mutation	NA	V1169I	0.3
STAD	chr2	197392338	Missense_Mutation	novel	T1294A	0.38
STAD	chr2	197393160	Missense_Mutation	novel	A1190T	0.44
STAD	chr2	197408383	Missense_Mutation	novel	A368D	0.32	SF3b1
STAD	chr2	197423824	Missense_Mutation	novel	A60V	0.48
STAD	chr2	197420351	Intron	NA		0.45
STAD	chr2	197408397	Silent	NA	P363P	0.06
STAD	chr2	197398551	Missense_Mutation	NA	D1015G	0.06
STAD	chr2	197408506	Missense_Mutation	novel	P327R	0.37
STAD	chr2	197392328	Missense_Mutation	NA	R1297H	0.06
STAD	chr2	197392999	Silent	rs780385656	P1243P	0.18
STAD	chr2	197403751	Missense_Mutation	NA	Q518R	0.22
STAD	chr2	197420472	Missense_Mutation	novel	R124Q	0.06
STAD	chr2	197421033	Missense_Mutation	NA	E99G	0.13
STAD	chr2	197398087	Missense_Mutation	NA	W1055L	0.15
STAD	chr2	197403673	Missense_Mutation	NA	L544P	0.24
TGCT	chr2	197419135	Intron	novel		0.16
THCA	chr2	197434980	Missense_Mutation	rs190499887	T7I	0.31
THCA	chr2	197400807	Missense_Mutation	NA	M876L	0.35
THYM	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.24
THYM	chr2	197402110	Missense_Mutation	rs559063155	K700E	0.08
THYM	chr2	197408439	Silent	novel	S349S	0.44
UCEC	chr2	197400093	Missense_Mutation	novel	S992I	0.17
UCEC	chr2	197400392	Missense_Mutation	novel	L921F	0.25
UCEC	chr2	197393168	Missense_Mutation	NA	T1187M	0.06
UCEC	chr2	197392166	3'UTR	novel		0.43
UCEC	chr2	197400283	Missense_Mutation	rs773349667	R957Q	0.29
UCEC	chr2	197408485	Missense_Mutation	NA	R334I	0.34	SF3b1
UCEC	chr2	197396091	Silent	rs750426696	A1168A	0.42
UCEC	chr2	197403659	Missense_Mutation	NA	R549C	0.23
UCEC	chr2	197408107	Missense_Mutation	novel	S377N	0.41	SF3b1
UCEC	chr2	197392328	Missense_Mutation	NA	R1297H	0.29
UCEC	chr2	197435026	5'UTR	novel		0.36
UCEC	chr2	197392106	3'UTR	novel		0.35
UCEC	chr2	197400283	Missense_Mutation	rs773349667	R957Q	0.42
UCEC	chr2	197416749	Missense_Mutation	NA	Q220K	0.37
UCEC	chr2	197405438	Missense_Mutation	NA	R425Q	0.36	SF3b1
UCEC	chr2	197408384	Missense_Mutation	novel	A368T	0.28	SF3b1
UCEC	chr2	197405109	Missense_Mutation	novel	L502F	0.26
UCEC	chr2	197408542	Missense_Mutation	NA	R315Q	0.33
UCEC	chr2	197409843	Silent	rs13012433	A277A	0.26
UCEC	chr2	197400283	Missense_Mutation	rs773349667	R957Q	0.19
UCEC	chr2	197416906	Silent	novel	E167E	0.07
UCEC	chr2	197402626	Missense_Mutation	NA	Q669H	0.41
UCEC	chr2	197400082	Missense_Mutation	NA	A996S	0.23
UCEC	chr2	197402671	Silent	NA	S654S	0.3
UCEC	chr2	197392458	Missense_Mutation	novel	L1254M	0.24
UCEC	chr2	197409968	Missense_Mutation	novel	P236S	0.2
UCEC	chr2	197408048	Missense_Mutation	NA	R397C	0.49	SF3b1
UCEC	chr2	197418908	Intron	rs368295108		0.46
UCEC	chr2	197420390	Intron	NA		0.53
UCEC	chr2	197421117	Missense_Mutation	NA	S71L	0.37
UCEC	chr2	197408542	Missense_Mutation	NA	R315Q	0.44
UCEC	chr2	197400434	Missense_Mutation	NA	D907Y	0.44
UCEC	chr2	197398496	Missense_Mutation	novel	E1033D	0.54
UCEC	chr2	197403586	Missense_Mutation	novel	K573T	0.53
UCEC	chr2	197400125	Nonsense_Mutation	novel	Y981*	0.13
UCEC	chr2	197418588	Missense_Mutation	novel	G139E	0.29
UCEC	chr2	197400138	Missense_Mutation	novel	V977A	0.43
UCEC	chr2	197401752	Frame_Shift_Ins	novel	*I787Nfs21**	0.33
UCEC	chr2	197401789	Nonsense_Mutation	novel	R775*	0.37
UCEC	chr2	197398492	Missense_Mutation	novel	C1035G	0.36
UCEC	chr2	197392442	Missense_Mutation	rs771847036	R1259Q	0.34
UCEC	chr2	197401404	Missense_Mutation	NA	R831Q	0.44
UCEC	chr2	197418565	Missense_Mutation	novel	M147V	0.41
UCEC	chr2	197420472	Missense_Mutation	novel	R124Q	0.52
UCEC	chr2	197423883	Silent	novel	D40D	0.36
UCEC	chr2	197392458	Missense_Mutation	novel	L1254M	0.44
UCEC	chr2	197396082	Silent	novel	P1171P	0.54
UCEC	chr2	197393159	Missense_Mutation	novel	A1190E	0.42
UCEC	chr2	197400398	Missense_Mutation	novel	N919H	0.43
UCEC	chr2	197405147	Missense_Mutation	NA	E490K	0.39
UCEC	chr2	197393153	Missense_Mutation	novel	V1192A	0.33
UCEC	chr2	197400333	Silent	novel	L940L	0.34
UCEC	chr2	197418540	Missense_Mutation	novel	V155A	0.24
UCEC	chr2	197418575	Silent	NA	P143P	0.36
UCEC	chr2	197392040	3'UTR	novel		0.18
UCEC	chr2	197398520	Silent	novel	K1025K	0.21
UCEC	chr2	197401404	Missense_Mutation	NA	R831Q	0.1
UCEC	chr2	197403734	Missense_Mutation	novel	R524C	0.21
UCEC	chr2	197392329	Missense_Mutation	rs267599149	R1297C	0.49
UCEC	chr2	197398024	Missense_Mutation	novel	A1076V	0.31
UCEC	chr2	197392458	Silent	novel	L1254L	0.53
UCEC	chr2	197400365	Missense_Mutation	NA	P930S	0.26
UCEC	chr2	197408479	Nonsense_Mutation	NA	S336*	0.37	SF3b1
UCEC	chr2	197423954	Nonsense_Mutation	NA	E17*	0.21
UCEC	chr2	197400315	Missense_Mutation	novel	K946N	0.21
UCEC	chr2	197405335	Missense_Mutation	novel	Q459H	0.18
UCEC	chr2	197398546	Silent	NA	L1017L	0.15
UCEC	chr2	197420491	Missense_Mutation	novel	E118K	0.05
UCEC	chr2	197401483	Missense_Mutation	novel	Y805N	0.24
UCEC	chr2	197402631	Missense_Mutation	novel	V668I	0.14
UCEC	chr2	197405438	Missense_Mutation	NA	R425Q	0.12	SF3b1
UCEC	chr2	197400283	Missense_Mutation	rs773349667	R957Q	0.47
UCEC	chr2	197396145	Silent	rs560072330	S1150S	0.25
UCEC	chr2	197400283	Missense_Mutation	rs773349667	R957Q	0.21
UCEC	chr2	197420351	Intron	NA		0.3
UCEC	chr2	197408542	Missense_Mutation	NA	R315Q	0.36
UCEC	chr2	197408506	Missense_Mutation	novel	P327L	0.21
UCEC	chr2	197396208	Silent	NA	L1129L	0.39
UCEC	chr2	197420473	Missense_Mutation	novel	R124W	0.3
UCEC	chr2	197403659	Missense_Mutation	NA	R549C	0.26
UCEC	chr2	197393070	Missense_Mutation	novel	F1220V	0.23
UCS	chr2	197409948	Silent	rs762313406	S242S	0.44
UCS	chr2	197420538	Missense_Mutation	novel	D102A	0.7
UVM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.55
UVM	chr2	197402636	Missense_Mutation	rs374250186	K666T	0.47
UVM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.53
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.42
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.42
UVM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.43
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.46
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.41
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.38
UVM	chr2	197402646	Missense_Mutation	novel	T663P	0.43
UVM	chr2	197402636	Missense_Mutation	rs374250186	K666T	0.43
UVM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.4
UVM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.41
UVM	chr2	197402648	Missense_Mutation	novel	H662R	0.51
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.42
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.41
UVM	chr2	197402759	Missense_Mutation	NA	R625H	0.35
UVM	chr2	197402760	Missense_Mutation	rs775623976	R625C	0.49

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1424	0.012962
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.0272	0.2014

Survival Analysis

Cancer	P-value	Q-value
ACC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.02	Kaplan-Meier Survival Analysis
SKCM	0.00089	Kaplan-Meier Survival Analysis
PRAD	0.035	Kaplan-Meier Survival Analysis
KIRP	0.02	Kaplan-Meier Survival Analysis
BLCA	0.035	Kaplan-Meier Survival Analysis
GBM	0.017	Kaplan-Meier Survival Analysis
LIHC	0.0035	Kaplan-Meier Survival Analysis
LGG	0.003	Kaplan-Meier Survival Analysis
CHOL	0.041	Kaplan-Meier Survival Analysis
LUAD	0.02	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000115524 (Gene tree)
Gene ID: 23451
Gene Symbol: SF3B1
Alias: SAP155|SF3b155|PRPF10|Prp10|Hsh155
Full Name: splicing factor 3b subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 45,308 bases
Position: chr2:197,389,784-197,435,091
Accession: 10768
RBP type: canonical RBP
Summary: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000335321	SF3b1	PF08920.10	1.6e-46	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16906767	The SF3b155 N-terminal domain is a scaffold important for splicing.	Biochemistry	2006 Aug 22	Cass DM	-
26846640	RNA Splicing: Regulation and Dysregulation in the Heart.	Circ Res	2016 Feb 5	van den Hoogenhof MM	doi: 10.1161/CIRCRESAHA.115.307872.
16495236	Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing.	RNA	2006 Mar	Spadaccini R	-
15171797	Multisite phosphorylation of Pin1-associated mitotic phosphoproteins revealed by monoclonal antibodies MPM-2 and CC-3.	BMC Cell Biol	2004 Jun 1	Albert AL	-
27720643	Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.	Mol Cell	2016 Oct 20	Cretu C	doi: 10.1016/j.molcel.2016.08.036
18076038	Complex assembly mechanism and an RNA-binding mode of the human p14-SF3b155 spliceosomal protein complex identified by NMR solution structure and functional analyses.	Proteins	2008 Jun	Kuwasako K	-
21062891	Structural model of the p14/SF3b155 branch duplex complex.	RNA	2011 Jan	Schellenberg MJ	doi: 10.1261/rna.2224411
26531823	A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis.	Nucleic Acids Res	2016 Jan 29	Pimentel H	doi: 10.1093/nar/gkv1168
28545085	Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.	PLoS One	2017 May 18	Jin S	doi: 10.1371/journal.pone.0175523
16603771	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.	J Biol Chem	2006 Jun 16	Cavellan E	-
16790528	SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.	FASEB J	2006 Aug	Massiello A	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496458	SF3B1-212	475	-	-	- (aa)	-	-
ENST00000470268	SF3B1-208	2003	-	-	- (aa)	-	-
ENST00000335508	SF3B1-201	6526	-	ENSP00000335321	1304 (aa)	-	O75533
ENST00000414963	SF3B1-204	651	-	ENSP00000402997	144 (aa)	-	O75533
ENST00000479532	SF3B1-209	587	-	-	- (aa)	-	-
ENST00000424674	SF3B1-205	723	-	ENSP00000409435	241 (aa)	-	H7C341
ENST00000482158	SF3B1-210	772	-	-	- (aa)	-	-
ENST00000487698	SF3B1-211	2127	-	ENSP00000419896	154 (aa)	-	B4DGZ4
ENST00000462613	SF3B1-206	141	-	-	- (aa)	-	-
ENST00000409915	SF3B1-202	600	-	ENSP00000428820	144 (aa)	-	O75533
ENST00000414174	SF3B1-203	593	-	ENSP00000392117	37 (aa)	-	F8WC19
ENST00000468925	SF3B1-207	510	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000115524's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115524	Schizophrenia	2E-11	25056061
ENSG00000115524	Schizophrenia	5E-11	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115524	rs699319	2	197417052	C	Major depressive disorder	27479909	[0.02-0.044] unit increase	0.0318	EFO_0003761

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115524's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115524	SF3B1	100	93.622	ENSAPOG00000011894	sf3b1	100	93.622	Acanthochromis_polyacanthus
ENSG00000115524	SF3B1	99	99.923	ENSAMEG00000013809	SF3B1	99	99.923	Ailuropoda_melanoleuca
ENSG00000115524	SF3B1	100	93.216	ENSACIG00000020910	sf3b1	97	93.064	Amphilophus_citrinellus
ENSG00000115524	SF3B1	100	93.622	ENSAOCG00000004478	sf3b1	100	93.622	Amphiprion_ocellaris
ENSG00000115524	SF3B1	100	93.622	ENSAPEG00000012937	sf3b1	100	93.622	Amphiprion_percula
ENSG00000115524	SF3B1	100	93.693	ENSATEG00000020435	sf3b1	100	93.693	Anabas_testudineus
ENSG00000115524	SF3B1	99	99.382	ENSAPLG00000003993	SF3B1	99	99.382	Anas_platyrhynchos
ENSG00000115524	SF3B1	100	98.850	ENSACAG00000009612	SF3B1	100	98.850	Anolis_carolinensis
ENSG00000115524	SF3B1	100	100.000	ENSANAG00000021577	SF3B1	100	100.000	Aotus_nancymaae
ENSG00000115524	SF3B1	100	92.857	ENSACLG00000023470	sf3b1	100	92.705	Astatotilapia_calliptera
ENSG00000115524	SF3B1	100	94.149	ENSAMXG00000002219	sf3b1	100	93.997	Astyanax_mexicanus
ENSG00000115524	SF3B1	100	100.000	ENSBTAG00000008915	SF3B1	100	99.923	Bos_taurus
ENSG00000115524	SF3B1	92	85.068	WBGene00011605	sftb-1	98	66.516	Caenorhabditis_elegans
ENSG00000115524	SF3B1	100	100.000	ENSCJAG00000003902	SF3B1	100	100.000	Callithrix_jacchus
ENSG00000115524	SF3B1	100	100.000	ENSCAFG00000010826	SF3B1	100	100.000	Canis_familiaris
ENSG00000115524	SF3B1	100	100.000	ENSCAFG00020004750	SF3B1	100	100.000	Canis_lupus_dingo
ENSG00000115524	SF3B1	100	100.000	ENSCHIG00000015226	SF3B1	100	99.923	Capra_hircus
ENSG00000115524	SF3B1	100	100.000	ENSTSYG00000009214	SF3B1	100	99.923	Carlito_syrichta
ENSG00000115524	SF3B1	99	99.846	ENSCAPG00000006547	SF3B1	99	99.846	Cavia_aperea
ENSG00000115524	SF3B1	99	100.000	ENSCPOG00000009353	SF3B1	100	100.000	Cavia_porcellus
ENSG00000115524	SF3B1	100	100.000	ENSCCAG00000020506	SF3B1	100	100.000	Cebus_capucinus
ENSG00000115524	SF3B1	100	100.000	ENSCATG00000035735	SF3B1	100	100.000	Cercocebus_atys
ENSG00000115524	SF3B1	99	100.000	ENSCLAG00000014767	SF3B1	99	100.000	Chinchilla_lanigera
ENSG00000115524	SF3B1	100	100.000	ENSCSAG00000011505	SF3B1	100	100.000	Chlorocebus_sabaeus
ENSG00000115524	SF3B1	100	100.000	ENSCHOG00000009860	SF3B1	76	98.438	Choloepus_hoffmanni
ENSG00000115524	SF3B1	100	100.000	ENSCPBG00000021902	SF3B1	100	99.233	Chrysemys_picta_bellii
ENSG00000115524	SF3B1	68	78.060	ENSCING00000002558	-	99	78.771	Ciona_intestinalis
ENSG00000115524	SF3B1	94	90.265	ENSCSAVG00000002559	-	99	79.470	Ciona_savignyi
ENSG00000115524	SF3B1	100	100.000	ENSCANG00000029415	SF3B1	100	100.000	Colobus_angolensis_palliatus
ENSG00000115524	SF3B1	100	100.000	ENSCGRG00001016990	Sf3b1	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000115524	SF3B1	100	100.000	ENSCGRG00000005301	Sf3b1	100	100.000	Cricetulus_griseus_crigri
ENSG00000115524	SF3B1	94	97.788	ENSCSEG00000003860	sf3b1	100	89.939	Cynoglossus_semilaevis
ENSG00000115524	SF3B1	94	97.788	ENSCVAG00000003680	sf3b1	99	93.676	Cyprinodon_variegatus
ENSG00000115524	SF3B1	100	93.470	ENSDARG00000056138	sf3b1	100	93.394	Danio_rerio
ENSG00000115524	SF3B1	100	100.000	ENSDNOG00000011754	SF3B1	100	99.923	Dasypus_novemcinctus
ENSG00000115524	SF3B1	99	97.297	ENSDORG00000002399	Sf3b1	100	97.297	Dipodomys_ordii
ENSG00000115524	SF3B1	94	92.035	FBgn0031266	Sf3b1	100	76.618	Drosophila_melanogaster
ENSG00000115524	SF3B1	90	99.225	ENSETEG00000009188	SF3B1	100	99.351	Echinops_telfairi
ENSG00000115524	SF3B1	94	96.018	ENSEBUG00000004325	sf3b1	100	90.191	Eptatretus_burgeri
ENSG00000115524	SF3B1	100	100.000	ENSEASG00005020159	SF3B1	98	99.923	Equus_asinus_asinus
ENSG00000115524	SF3B1	100	100.000	ENSECAG00000021657	SF3B1	98	99.923	Equus_caballus
ENSG00000115524	SF3B1	100	100.000	ENSEEUG00000000836	SF3B1	81	100.000	Erinaceus_europaeus
ENSG00000115524	SF3B1	100	93.132	ENSELUG00000005977	sf3b1	98	92.981	Esox_lucius
ENSG00000115524	SF3B1	100	100.000	ENSFCAG00000005038	SF3B1	100	100.000	Felis_catus
ENSG00000115524	SF3B1	99	99.459	ENSFALG00000004281	SF3B1	99	99.459	Ficedula_albicollis
ENSG00000115524	SF3B1	100	100.000	ENSFDAG00000017510	SF3B1	100	100.000	Fukomys_damarensis
ENSG00000115524	SF3B1	100	92.938	ENSFHEG00000014333	sf3b1	100	92.938	Fundulus_heteroclitus
ENSG00000115524	SF3B1	100	93.531	ENSGMOG00000006773	sf3b1	100	93.531	Gadus_morhua
ENSG00000115524	SF3B1	100	99.387	ENSGALG00000008038	SF3B1	100	99.387	Gallus_gallus
ENSG00000115524	SF3B1	100	91.915	ENSGAFG00000000704	sf3b1	99	93.441	Gambusia_affinis
ENSG00000115524	SF3B1	100	93.674	ENSGACG00000008839	sf3b1	100	93.674	Gasterosteus_aculeatus
ENSG00000115524	SF3B1	100	98.553	ENSGAGG00000017478	SF3B1	100	98.553	Gopherus_agassizii
ENSG00000115524	SF3B1	99	93.170	ENSGGOG00000009264	SF3B1	99	94.231	Gorilla_gorilla
ENSG00000115524	SF3B1	99	92.922	ENSHBUG00000007705	sf3b1	99	92.770	Haplochromis_burtoni
ENSG00000115524	SF3B1	99	100.000	ENSHGLG00000008285	-	99	100.000	Heterocephalus_glaber_female
ENSG00000115524	SF3B1	99	97.992	ENSHGLG00100005535	-	99	97.992	Heterocephalus_glaber_male
ENSG00000115524	SF3B1	100	92.976	ENSHCOG00000016775	sf3b1	100	92.825	Hippocampus_comes
ENSG00000115524	SF3B1	100	93.997	ENSIPUG00000013171	sf3b1	100	93.997	Ictalurus_punctatus
ENSG00000115524	SF3B1	100	100.000	ENSSTOG00000011034	SF3B1	100	100.000	Ictidomys_tridecemlineatus
ENSG00000115524	SF3B1	99	99.922	ENSJJAG00000010903	Sf3b1	99	99.922	Jaculus_jaculus
ENSG00000115524	SF3B1	100	93.106	ENSKMAG00000004009	sf3b1	100	93.030	Kryptolebias_marmoratus
ENSG00000115524	SF3B1	100	93.588	ENSLBEG00000022208	sf3b1	100	93.435	Labrus_bergylta
ENSG00000115524	SF3B1	99	92.490	ENSLACG00000014832	SF3B1	99	92.490	Latimeria_chalumnae
ENSG00000115524	SF3B1	100	94.917	ENSLOCG00000003899	sf3b1	100	94.765	Lepisosteus_oculatus
ENSG00000115524	SF3B1	100	100.000	ENSLAFG00000001956	SF3B1	100	100.000	Loxodonta_africana
ENSG00000115524	SF3B1	99	100.000	ENSMMUG00000022430	SF3B1	99	100.000	Macaca_mulatta
ENSG00000115524	SF3B1	100	100.000	ENSMNEG00000042333	SF3B1	100	100.000	Macaca_nemestrina
ENSG00000115524	SF3B1	94	97.788	ENSMLEG00000026141	SF3B1	99	94.027	Mandrillus_leucophaeus
ENSG00000115524	SF3B1	100	93.617	ENSMAMG00000010241	sf3b1	100	93.617	Mastacembelus_armatus
ENSG00000115524	SF3B1	100	92.857	ENSMZEG00005021254	sf3b1	100	92.705	Maylandia_zebra
ENSG00000115524	SF3B1	99	98.764	ENSMGAG00000007017	SF3B1	99	98.764	Meleagris_gallopavo
ENSG00000115524	SF3B1	100	100.000	ENSMAUG00000009071	Sf3b1	99	95.753	Mesocricetus_auratus
ENSG00000115524	SF3B1	100	100.000	ENSMICG00000013879	SF3B1	100	99.923	Microcebus_murinus
ENSG00000115524	SF3B1	99	95.525	ENSMOCG00000000455	Sf3b1	99	95.525	Microtus_ochrogaster
ENSG00000115524	SF3B1	97	82.979	ENSMMOG00000000475	sf3b1	100	93.059	Mola_mola
ENSG00000115524	SF3B1	100	100.000	ENSMODG00000012275	SF3B1	100	99.310	Monodelphis_domestica
ENSG00000115524	SF3B1	100	93.541	ENSMALG00000017211	sf3b1	100	93.541	Monopterus_albus
ENSG00000115524	SF3B1	100	100.000	MGP_CAROLIEiJ_G0014141	Sf3b1	100	100.000	Mus_caroli
ENSG00000115524	SF3B1	100	100.000	ENSMUSG00000025982	Sf3b1	100	100.000	Mus_musculus
ENSG00000115524	SF3B1	100	100.000	MGP_SPRETEiJ_G0014947	Sf3b1	100	100.000	Mus_spretus
ENSG00000115524	SF3B1	100	100.000	ENSMPUG00000007799	SF3B1	100	100.000	Mustela_putorius_furo
ENSG00000115524	SF3B1	100	100.000	ENSMLUG00000000840	SF3B1	100	98.773	Myotis_lucifugus
ENSG00000115524	SF3B1	99	99.692	ENSNGAG00000021884	-	100	99.692	Nannospalax_galili
ENSG00000115524	SF3B1	94	97.788	ENSNBRG00000015816	sf3b1	100	89.109	Neolamprologus_brichardi
ENSG00000115524	SF3B1	100	100.000	ENSNLEG00000006861	SF3B1	100	100.000	Nomascus_leucogenys
ENSG00000115524	SF3B1	70	100.000	ENSMEUG00000015848	-	67	100.000	Notamacropus_eugenii
ENSG00000115524	SF3B1	100	100.000	ENSOPRG00000008596	SF3B1	100	88.113	Ochotona_princeps
ENSG00000115524	SF3B1	100	100.000	ENSODEG00000011153	-	100	100.000	Octodon_degus
ENSG00000115524	SF3B1	100	92.857	ENSONIG00000013758	sf3b1	100	92.705	Oreochromis_niloticus
ENSG00000115524	SF3B1	94	97.788	ENSOCUG00000012722	-	96	98.985	Oryctolagus_cuniculus
ENSG00000115524	SF3B1	100	93.389	ENSORLG00000020219	sf3b1	100	93.389	Oryzias_latipes
ENSG00000115524	SF3B1	100	93.389	ENSORLG00020001746	sf3b1	100	93.389	Oryzias_latipes_hni
ENSG00000115524	SF3B1	100	82.051	ENSORLG00015001759	sf3b1	98	90.952	Oryzias_latipes_hsok
ENSG00000115524	SF3B1	100	93.394	ENSOMEG00000019231	sf3b1	100	93.394	Oryzias_melastigma
ENSG00000115524	SF3B1	100	100.000	ENSOGAG00000000267	-	100	82.965	Otolemur_garnettii
ENSG00000115524	SF3B1	100	100.000	ENSOARG00000015374	SF3B1	100	99.923	Ovis_aries
ENSG00000115524	SF3B1	100	100.000	ENSPPAG00000035007	SF3B1	100	100.000	Pan_paniscus
ENSG00000115524	SF3B1	100	100.000	ENSPPRG00000009090	SF3B1	100	100.000	Panthera_pardus
ENSG00000115524	SF3B1	100	100.000	ENSPTIG00000021557	SF3B1	100	100.000	Panthera_tigris_altaica
ENSG00000115524	SF3B1	94	97.788	ENSPTRG00000012771	SF3B1	99	91.455	Pan_troglodytes
ENSG00000115524	SF3B1	100	100.000	ENSPANG00000013417	SF3B1	100	100.000	Papio_anubis
ENSG00000115524	SF3B1	100	95.053	ENSPKIG00000000784	sf3b1	100	94.901	Paramormyrops_kingsleyae
ENSG00000115524	SF3B1	99	97.991	ENSPSIG00000017222	SF3B1	98	97.991	Pelodiscus_sinensis
ENSG00000115524	SF3B1	90	94.019	ENSPMGG00000004330	sf3b1	99	93.850	Periophthalmus_magnuspinnatus
ENSG00000115524	SF3B1	99	100.000	ENSPEMG00000010699	Sf3b1	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000115524	SF3B1	94	96.460	ENSPMAG00000001311	sf3b1	100	90.205	Petromyzon_marinus
ENSG00000115524	SF3B1	100	99.233	ENSPCIG00000010642	SF3B1	100	99.233	Phascolarctos_cinereus
ENSG00000115524	SF3B1	100	93.323	ENSPFOG00000000073	sf3b1	100	93.323	Poecilia_formosa
ENSG00000115524	SF3B1	100	93.394	ENSPLAG00000002293	sf3b1	100	93.394	Poecilia_latipinna
ENSG00000115524	SF3B1	100	93.394	ENSPMEG00000000446	sf3b1	98	93.394	Poecilia_mexicana
ENSG00000115524	SF3B1	100	93.470	ENSPREG00000019652	sf3b1	100	93.470	Poecilia_reticulata
ENSG00000115524	SF3B1	100	100.000	ENSPPYG00000013044	SF3B1	96	98.814	Pongo_abelii
ENSG00000115524	SF3B1	100	100.000	ENSPCAG00000009292	SF3B1	100	99.847	Procavia_capensis
ENSG00000115524	SF3B1	100	100.000	ENSPCOG00000024074	SF3B1	100	99.923	Propithecus_coquereli
ENSG00000115524	SF3B1	100	100.000	ENSPVAG00000008302	SF3B1	100	100.000	Pteropus_vampyrus
ENSG00000115524	SF3B1	100	92.781	ENSPNYG00000014939	sf3b1	100	92.629	Pundamilia_nyererei
ENSG00000115524	SF3B1	100	93.997	ENSPNAG00000008288	sf3b1	100	93.997	Pygocentrus_nattereri
ENSG00000115524	SF3B1	100	100.000	ENSRNOG00000013516	Sf3b1	100	100.000	Rattus_norvegicus
ENSG00000115524	SF3B1	99	96.237	ENSRBIG00000026096	SF3B1	100	96.237	Rhinopithecus_bieti
ENSG00000115524	SF3B1	100	100.000	ENSRROG00000031308	SF3B1	100	100.000	Rhinopithecus_roxellana
ENSG00000115524	SF3B1	100	100.000	ENSSBOG00000020080	SF3B1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000115524	SF3B1	100	100.000	ENSSHAG00000017564	SF3B1	100	99.310	Sarcophilus_harrisii
ENSG00000115524	SF3B1	100	94.609	ENSSFOG00015021535	sf3b1	100	94.761	Scleropages_formosus
ENSG00000115524	SF3B1	99	92.955	ENSSMAG00000013977	sf3b1	99	92.803	Scophthalmus_maximus
ENSG00000115524	SF3B1	100	93.389	ENSSDUG00000017422	sf3b1	100	93.389	Seriola_dumerili
ENSG00000115524	SF3B1	100	93.313	ENSSLDG00000019495	sf3b1	100	93.313	Seriola_lalandi_dorsalis
ENSG00000115524	SF3B1	94	97.788	ENSSARG00000007016	SF3B1	76	100.000	Sorex_araneus
ENSG00000115524	SF3B1	100	100.000	ENSSPUG00000000410	SF3B1	100	99.080	Sphenodon_punctatus
ENSG00000115524	SF3B1	100	93.693	ENSSPAG00000010451	sf3b1	99	93.693	Stegastes_partitus
ENSG00000115524	SF3B1	100	100.000	ENSSSCG00000016075	SF3B1	100	100.000	Sus_scrofa
ENSG00000115524	SF3B1	100	99.310	ENSTGUG00000010553	SF3B1	100	99.310	Taeniopygia_guttata
ENSG00000115524	SF3B1	100	93.389	ENSTRUG00000015534	sf3b1	100	93.237	Takifugu_rubripes
ENSG00000115524	SF3B1	100	100.000	ENSTBEG00000008714	SF3B1	93	100.000	Tupaia_belangeri
ENSG00000115524	SF3B1	100	100.000	ENSTTRG00000003414	SF3B1	92	94.185	Tursiops_truncatus
ENSG00000115524	SF3B1	94	97.788	ENSUAMG00000018506	SF3B1	99	99.190	Ursus_americanus
ENSG00000115524	SF3B1	100	100.000	ENSUMAG00000020945	SF3B1	100	100.000	Ursus_maritimus
ENSG00000115524	SF3B1	100	100.000	ENSVPAG00000005798	SF3B1	100	91.871	Vicugna_pacos
ENSG00000115524	SF3B1	100	100.000	ENSVVUG00000025948	SF3B1	95	100.000	Vulpes_vulpes
ENSG00000115524	SF3B1	100	96.628	ENSXETG00000013339	sf3b1	100	96.628	Xenopus_tropicalis
ENSG00000115524	SF3B1	94	97.788	ENSXCOG00000018086	sf3b1	100	89.794	Xiphophorus_couchianus
ENSG00000115524	SF3B1	100	93.394	ENSXMAG00000007369	sf3b1	100	93.692	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	-	IEA	Process
GO:0000375	RNA splicing, via transesterification reactions	9585501.	NAS	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	11252167.28781166.29360106.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	9585501.	NAS	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005515	protein binding	19515850.21062891.22365833.26575292.	IPI	Function
GO:0005634	nucleus	18559850.28781166.29360106.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9585501.	NAS	Component
GO:0005686	U2 snRNP	21873635.	IBA	Component
GO:0005686	U2 snRNP	11252167.	IDA	Component
GO:0005689	U12-type spliceosomal complex	21873635.	IBA	Component
GO:0005689	U12-type spliceosomal complex	15146077.	IDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0034693	U11/U12 snRNP	11252167.	IDA	Component
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	Process
GO:0071004	U2-type prespliceosome	21873635.	IBA	Component
GO:0071005	U2-type precatalytic spliceosome	28781166.29360106.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.