EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16378916	Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study.	J Soc Gynecol Investig	2006 Jan	Gabriel B	-
21377781	FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells.	Cancer Lett	2011 May 28	Ng CF	doi: 10.1016/j.canlet.2011.02.001
19139564	Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.	J Clin Invest	2009 Feb	Ding L	doi: 10.1172/JCI35930
26973248	Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells.	Oncogene	2016 Sep 29	Jin H	doi: 10.1038/onc.2016.54
27415427	The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription.	Cell Death Dis	2016 Jul 14	Hua G	doi: 10.1038/cddis.2016.207.
20734429	Synergistic repression of estrogen receptor transcriptional activity by FHL2 and Smad4 in breast cancer cells.	IUBMB Life	2010 Sep	Xiong Z	doi: 10.1002/iub.367.
17682292	FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells.	Cell Cycle	2007 Jul 15	Martin BT	-
21826055	FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer.	Lab Invest	2011 Dec	Gullotti L	doi: 10.1038/labinvest.2011.109
25554651	Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer.	Pathol Res Pract	2015 Feb	Al-Nomani L	doi: 10.1016/j.prp.2014.12.001
20460358	Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer.	Carcinogenesis	2010 Jul	Zhang W	doi: 10.1093/carcin/bgq094
27129278	Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion.	J Biol Chem	2016 Jul 1	Boateng LR	doi: 10.1074/jbc.M116.725739
12466281	Identification of the LIM protein FHL2 as a coactivator of beta-catenin.	J Biol Chem	2003 Feb 14	Wei Y	-
26320172	KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.	Oncotarget	2015 Sep 22	Yan Q	doi: 10.18632/oncotarget.4517.
17145880	Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence.	Cancer Res	2006 Dec 1	Kahl P	-
23756870	Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer.	Br J Cancer	2013 Jul 9	Verset L	doi: 10.1038/bjc.2013.290
14550570	BRCA1 interacts with FHL2 and enhances FHL2 transactivation function.	FEBS Lett	2003 Oct 9	Yan J	-
24008552	A novel colon cancer gene therapy using rAAVmediated expression of human shRNA-FHL2.	Int J Oncol	2013 Nov	Wu Y	doi: 10.3892/ijo.2013.2090
17975004	Androgen induction of the androgen receptor coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancer.	Cancer Res	2007 Nov 1	Heemers HV	-
17192406	Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2.	Mol Endocrinol	2007 Mar	Nair SS	-
25917075	LIM-only protein FHL2 critically determines survival and radioresistance of pancreatic cancer cells.	Cancer Lett	2015 Aug 1	Zienert E	doi: 10.1016/j.canlet.2015.04.019
15692560	Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.	EMBO J	2005 Mar 9	Yang Y	-
28349819	ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer.	Tumour Biol	2017 Mar	Verset L	doi: 10.1177/1010428317695024.
29800735	Increased expression of FHL2 promotes tumorigenesis in cervical cancer and is correlated with poor prognosis.	Gene	2018 Aug 30	Jin X	doi: 10.1016/j.gene.2018.05.087

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	105396726	Intron	novel		0.46
BLCA	chr2	105398909	Intron	novel		0.37
BLCA	chr2	105367648	Silent	novel	F141F	0.18
BLCA	chr2	105361195	3'UTR	novel		0.51
BLCA	chr2	105363364	Silent	rs745753003	R203R	0.21
BLCA	chr2	105361331	Silent	novel	L264L	0.37
BLCA	chr2	105373667	Missense_Mutation	novel	L75M	0.33
BRCA	chr2	105399366	5'Flank	novel		0.34
BRCA	chr2	105363389	Missense_Mutation	NA	L195Q	0.36
BRCA	chr2	105361355	Silent	novel	L256L	0.07
BRCA	chr2	105373716	Missense_Mutation	NA	D58E	0.21
BRCA	chr2	105399357	5'Flank	novel		0.16
CESC	chr2	105360884	3'UTR	rs766063018		0.32
CESC	chr2	105399432	5'Flank	novel		0.26
COAD	chr2	105363360	Missense_Mutation	NA	D205Y	0.38
COAD	chr2	105396715	Intron	novel		0.35
COAD	chr2	105386507	Missense_Mutation	rs536715218	R4C	0.39
COAD	chr2	105396754	Intron	novel		0.17
COAD	chr2	105373683	Silent	rs138189036	S69S	0.07
COAD	chr2	105398854	Intron	novel		0.18
GBM	chr2	105367643	Missense_Mutation	novel	P143L	0.48
GBM	chr2	105396818	Intron	novel		0.28
HNSC	chr2	105361336	Frame_Shift_Ins	novel	*F263Lfs28**	0.29
HNSC	chr2	105363415	Silent	novel	F186F	0.11
KIRC	chr2	105361423	Missense_Mutation	NA	T234A	0.16
LAML	chr2	105361268	3'UTR	novel		0.17
LIHC	chr2	105361184	3'UTR	novel		0.22
LIHC	chr2	105361122	3'UTR	novel		0.47
LIHC	chr2	105398908	Intron	novel		0.08
LIHC	chr2	105361370	Silent	NA	C251C	0.13
LUAD	chr2	105398846	Intron	novel		0.29
LUAD	chr2	105373686	Silent	rs749435663	C68C	0.22
LUAD	chr2	105398932	Intron	rs775482193		0.33
LUAD	chr2	105396746	Intron	novel		0.38
LUAD	chr2	105386433	Missense_Mutation	novel	C28W	0.5
LUSC	chr2	105398904	Intron	novel		0.38
LUSC	chr2	105361242	3'UTR	novel		0.1
LUSC	chr2	105361127	3'UTR	novel		0.32
LUSC	chr2	105373606	Missense_Mutation	rs727505151	N95S	0.19
LUSC	chr2	105398944	Intron	novel		0.5
OV	chr2	105361242	3'UTR	novel		0.07
OV	chr2	105361250	3'UTR	rs757735612		0.06
OV	chr2	105373667	Silent	NA	L75L	0.41
PAAD	chr2	105361434	Missense_Mutation	novel	G230E	0.15
READ	chr2	105361398	Missense_Mutation	rs188279857	R242Q	0.35
SARC	chr2	105361195	3'UTR	novel		0.39
SKCM	chr2	105363442	Silent	novel	R177R	0.21
SKCM	chr2	105373569	Silent	rs139644436	T107T	0.36
SKCM	chr2	105386456	Silent	NA	L21L	0.25
SKCM	chr2	105373692	Silent	novel	F66F	0.12
STAD	chr2	105386443	Missense_Mutation	NA	S25I	0.16
STAD	chr2	105363351	Missense_Mutation	novel	Y208H	0.16
STAD	chr2	105367680	Missense_Mutation	rs397517959	R131S	0.23
STAD	chr2	105363366	Missense_Mutation	NA	R203C	0.12
STAD	chr2	105386367	Frame_Shift_Del	novel	*I47Afs160**	0.03
STAD	chr2	105396655	5'UTR	novel		0.3
STAD	chr2	105373666	Missense_Mutation	NA	L75P	0.24
THCA	chr2	105367701	Missense_Mutation	novel	E124K	0.2
UCEC	chr2	105361321	Missense_Mutation	novel	D268N	0.4
UCEC	chr2	105396745	Intron	rs748454635		0.17
UCEC	chr2	105361403	Missense_Mutation	novel	E240D	0.53
UCEC	chr2	105367627	Missense_Mutation	novel	N148K	0.36
UCEC	chr2	105361318	Missense_Mutation	rs770706113	D269N	0.4
UCEC	chr2	105386522	5'UTR	rs766118919		0.39
UCEC	chr2	105386453	Missense_Mutation	rs750377257	R22W	0.49
UCEC	chr2	105399543	5'Flank	novel		0.35
UCEC	chr2	105360992	3'UTR	novel		0.24
UCEC	chr2	105361125	3'UTR	novel		0.38
UCEC	chr2	105399436	5'Flank	novel		0.31
UCEC	chr2	105361341	Missense_Mutation	rs371759004	R261H	0.2
UCEC	chr2	105399279	5'Flank	novel		0.48
UCEC	chr2	105399595	5'Flank	novel		0.53
UCEC	chr2	105386483	Missense_Mutation	rs777214115	E12K	0.41
UCEC	chr2	105373564	Missense_Mutation	novel	M109R	0.33
UCEC	chr2	105396783	Intron	novel		0.38
UCEC	chr2	105360935	3'UTR	rs1044097		0.4
UCEC	chr2	105361242	3'UTR	novel		0.24
UCEC	chr2	105367570	Missense_Mutation	novel	K167N	0.34
UCEC	chr2	105399369	5'Flank	novel		0.12
UCEC	chr2	105396746	Intron	rs772187730		0.29
UCEC	chr2	105360879	3'UTR	novel		0.16
UCEC	chr2	105363364	Silent	rs745753003	R203R	0.35
UCEC	chr2	105367708	Missense_Mutation	novel	S121R	0.24
UCEC	chr2	105386408	Missense_Mutation	rs74575749	A37T	0.29
UCEC	chr2	105363378	Missense_Mutation	rs373259092	R199C	0.22
UCEC	chr2	105360929	3'UTR	novel		0.32
UCEC	chr2	105361255	3'UTR	novel		0.45
UCEC	chr2	105361237	3'UTR	novel		0.34
UCEC	chr2	105361080	3'UTR	novel		0.33
UCEC	chr2	105373704	Silent	novel	H62H	0.16
UCEC	chr2	105396800	Intron	novel		0.17
UCEC	chr2	105399488	5'Flank	novel		0.41
UCEC	chr2	105363308	Missense_Mutation	novel	A222D	0.38
UCS	chr2	105386483	Missense_Mutation	rs777214115	E12K	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1667	0.15279
PAAD	DEL	0.0326	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00083	Kaplan-Meier Survival Analysis
MESO	0.036	Kaplan-Meier Survival Analysis
ACC	0.0021	Kaplan-Meier Survival Analysis
HNSC	0.0013	Kaplan-Meier Survival Analysis
LUSC	0.04	Kaplan-Meier Survival Analysis
PAAD	0.045	Kaplan-Meier Survival Analysis
CESC	0.0063	Kaplan-Meier Survival Analysis
GBM	0.0075	Kaplan-Meier Survival Analysis
THCA	0.0083	Kaplan-Meier Survival Analysis
LUAD	0.0019	Kaplan-Meier Survival Analysis
UVM	0.00023	Kaplan-Meier Survival Analysis
OV	0.049	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000115641 (Gene tree)
Gene ID: 2274
Gene Symbol: FHL2
Alias: SLIM3|DRAL
Full Name: four and a half LIM domains 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 81,062 bases
Position: chr2:105,357,712-105,438,773
Accession: 3703
RBP type: non-canonical RBP
Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22577521	Computational prediction of protein-protein interactions of human tyrosinase.	Enzyme Res	2012	Wang SF	doi: 10.1155/2012/192867

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000344213	FHL2-202	1769	-	ENSP00000344266	389 (aa)	-	J3KNW4
ENST00000447958	FHL2-209	574	-	ENSP00000397083	19 (aa)	-	C9J3S8
ENST00000409177	FHL2-207	4881	-	ENSP00000386892	395 (aa)	-	A0A0A0MSG2
ENST00000452732	FHL2-210	886	-	ENSP00000414872	54 (aa)	-	F8WDA8
ENST00000530340	FHL2-211	1876	-	ENSP00000433567	144 (aa)	-	E9PKF4
ENST00000409807	FHL2-208	1601	-	ENSP00000386665	279 (aa)	-	Q14192
ENST00000408995	FHL2-206	1367	-	ENSP00000386633	279 (aa)	-	Q14192
ENST00000322142	FHL2-201	1462	-	ENSP00000322909	279 (aa)	-	Q14192
ENST00000607522	FHL2-212	759	-	ENSP00000476199	65 (aa)	-	U3KQT4
ENST00000393352	FHL2-204	1426	XM_011510798	ENSP00000377020	279 (aa)	XP_011509100	Q14192
ENST00000393353	FHL2-205	1531	-	ENSP00000377021	279 (aa)	-	Q14192
ENST00000358129	FHL2-203	1578	-	ENSP00000350846	151 (aa)	-	Q14192

Gene Model

Click here to download ENSG00000115641's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04380	Osteoclast differentiation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115641	Body Mass Index	3.95992529659769E-7	17903300
ENSG00000115641	Body Weight	2.00693215788069E-9	17903300
ENSG00000115641	Body Weight	1.43545771001219E-7	17903300
ENSG00000115641	Body Weight	2.94040713817932E-6	17903300
ENSG00000115641	Body Weight	8.57569971311102E-7	17903300
ENSG00000115641	Body Weight	4.58302239087284E-7	17903300
ENSG00000115641	Body Weight	5.16078064489008E-8	17903300
ENSG00000115641	Body Weight	1.35181400047325E-8	17903300
ENSG00000115641	Body Mass Index	1.24429181841472E-7	17903300
ENSG00000115641	Body Weight	2.37430418032927E-6	17903300
ENSG00000115641	Body Weight	5.91317334873034E-8	17903300
ENSG00000115641	Cholesterol, HDL	8.85489686242025E-5	17903299
ENSG00000115641	Cholesterol, HDL	6.8050755579474E-5	17903299
ENSG00000115641	Blood Pressure	7.8370000E-005	-
ENSG00000115641	Blood Pressure	1.7689348E-005	-
ENSG00000115641	Platelet Function Tests	2.7718700E-005	-
ENSG00000115641	Platelet Function Tests	5.4600000E-006	-
ENSG00000115641	Skin-Hair-Eye Pigmentation, Variation In, 9	5.9800000E-006	22556244

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115641	rs3087523	2	105361319	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115641's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	15692560.	IDA	Process
GO:0001649	osteoblast differentiation	-	IEA	Process
GO:0003713	transcription coactivator activity	15572661.	NAS	Function
GO:0005515	protein binding	14550570.15692560.16624878.16888242.17360532.18255255.19608030.21516116.21988832.22829078.25416956.26871637.28717008.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0008134	transcription factor binding	15692560.	IPI	Function
GO:0009725	response to hormone	17975004.	IMP	Process
GO:0019216	regulation of lipid metabolic process	-	TAS	Process
GO:0030018	Z disc	21873635.	IBA	Component
GO:0030521	androgen receptor signaling pathway	15572661.	NAS	Process
GO:0031430	M band	-	IEA	Component
GO:0042802	identical protein binding	10906324.18255255.	IPI	Function
GO:0043066	negative regulation of apoptotic process	15692560.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	15572661.	NAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0050681	androgen receptor binding	15572661.	NAS	Function
GO:0055014	atrial cardiac muscle cell development	-	IEA	Process
GO:0055015	ventricular cardiac muscle cell development	-	IEA	Process
GO:0060347	heart trabecula formation	-	IEA	Process
GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	22851699.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.