EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29429983	Baculoviral IAP Repeat Containing 6 (BIRC6) Is a Predictor of Prognosis in Prostate Cancer.	Med Sci Monit	2018 Feb 10	Zhuang W	doi: 10.12659/MSM.904052.
27649954	Expression analysis of BRUCE protein in esophageal squamous cell carcinoma.	Ann Diagn Pathol	2016 Oct	Salehi S	doi: 10.1016/j.anndiagpath.2016.07.003
25933218	Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer.	PLoS One	2015 May 1	Hu T	doi: 10.1371/journal.pone.0125281
27663589	BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer.	Clin Cancer Res	2017 Mar 15	Luk IS	doi: 10.1158/1078-0432.CCR-16-0718
21542283	[Knock-down of apollon gene by antisense oligodeoxynucleotide inhibits the proliferation of Lovo cells and enhances chemo-sensitivity].	Yao Xue Xue Bao	2011 Feb	He JH	-
24453032	Expression and clinical significance of BIRC6 in human epithelial ovarian cancer.	Tumour Biol	2014 May	Wang L	doi: 10.1007/s13277-014-1641-6
23287853	Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance.	J Thorac Oncol	2013 Feb	Dong X	doi: 10.1097/JTO.0b013e31827d5237.
21788403	Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target.	Mol Cell Proteomics	2011 Dec	Van Houdt WJ	doi: 10.1074/mcp.M111.011353
19223905	Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation.	Br J Cancer	2009 Mar 10	Lopergolo A	doi: 10.1038/sj.bjc.6604927
26748613	Suppressive Effect of Constructed shRNAs against Apollon Induces Apoptosis and Growth Inhibition in the HeLa Cell Line.	Iran Biomed J	2016 Jul	Milani S	-
27614745	BRUCE Protein, New Marker for Targeted Therapy of Gastric Carcinoma.	J Gastrointest Cancer	2017 Jun	Salehi S	doi: 10.1007/s12029-016-9874-9.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	32448794	Splice_Site	NA	X1495_splice	0.38
BLCA	chr2	32377753	Missense_Mutation	novel	E164G	0.27
BLCA	chr2	32547957	Silent	novel	V4306V	0.32
BLCA	chr2	32491485	Missense_Mutation	NA	P2756R	0.38
BLCA	chr2	32388930	Missense_Mutation	novel	R276G	0.21
BLCA	chr2	32478806	Missense_Mutation	novel	D2414H	0.22
BLCA	chr2	32478638	Missense_Mutation	novel	L2358F	0.41
BLCA	chr2	32443504	Missense_Mutation	NA	D1418Y	0.11
BLCA	chr2	32445578	Missense_Mutation	NA	G1465E	0.27
BLCA	chr2	32448820	Missense_Mutation	NA	D1504N	0.22
BLCA	chr2	32607578	Nonsense_Mutation	NA	R4732*	0.35
BLCA	chr2	32508003	Missense_Mutation	novel	E3242K	0.33
BLCA	chr2	32594015	Missense_Mutation	novel	E4486Q	0.38
BLCA	chr2	32439557	Silent	novel	V1227V	0.35
BLCA	chr2	32515640	Missense_Mutation	novel	S3740L	0.21
BLCA	chr2	32593912	Splice_Region	novel		0.31
BLCA	chr2	32513063	Missense_Mutation	NA	H3493N	0.08
BLCA	chr2	32575209	Missense_Mutation	rs775855234	R4400W	0.36
BLCA	chr2	32401277	Silent	NA	D383D	0.39
BLCA	chr2	32617806	Nonsense_Mutation	novel	E4826*	0.14
BLCA	chr2	32453851	Silent	NA	F1554F	0.36
BLCA	chr2	32499663	Missense_Mutation	rs747507337	S2862L	0.49
BLCA	chr2	32513039	Missense_Mutation	novel	G3485S	0.11
BLCA	chr2	32513040	Missense_Mutation	novel	G3485V	0.1
BLCA	chr2	32415868	Silent	NA	L859L	0.43
BLCA	chr2	32513096	Missense_Mutation	novel	S3504G	0.27
BLCA	chr2	32392148	Missense_Mutation	NA	Q317E	0.2
BLCA	chr2	32414786	Missense_Mutation	novel	E499K	0.12
BLCA	chr2	32415033	Missense_Mutation	novel	S581L	0.08
BLCA	chr2	32464674	Missense_Mutation	rs567218300	L1703F	0.13
BLCA	chr2	32401547	Missense_Mutation	NA	D448N	0.45
BLCA	chr2	32415185	Missense_Mutation	novel	L632F	0.17
BLCA	chr2	32442136	Frame_Shift_Ins	novel	*D1340Ifs4**	0.06
BLCA	chr2	32442138	Frame_Shift_Ins	novel	*D1340Afs3**	0.05
BLCA	chr2	32607610	Silent	novel	E4742E	0.19
BLCA	chr2	32490148	Missense_Mutation	NA	N2735H	0.9
BLCA	chr2	32599801	Frame_Shift_Del	novel	*P4633Lfs11**	0.1
BLCA	chr2	32478775	Missense_Mutation	novel	W2403C	0.1
BLCA	chr2	32406519	Missense_Mutation	novel	S480L	0.4
BLCA	chr2	32515497	Frame_Shift_Del	novel	*V3693Yfs10**	0.31
BLCA	chr2	32469588	Silent	NA	E2107E	0.16
BLCA	chr2	32431020	Missense_Mutation	novel	Q1060E	0.45
BLCA	chr2	32415451	Silent	NA	L720L	0.29
BLCA	chr2	32603078	Missense_Mutation	novel	L4689M	0.35
BLCA	chr2	32401524	Missense_Mutation	novel	S440L	0.06
BLCA	chr2	32607522	Missense_Mutation	NA	R4713L	0.57
BLCA	chr2	32395521	Missense_Mutation	NA	S321C	0.33
BLCA	chr2	32453885	Missense_Mutation	NA	L1566V	0.27
BLCA	chr2	32415868	Silent	NA	L859L	0.14
BLCA	chr2	32515216	Missense_Mutation	NA	A3599T	0.1
BLCA	chr2	32441448	Silent	novel	S1310S	0.31
BLCA	chr2	32575293	Missense_Mutation	novel	E4428Q	0.13
BLCA	chr2	32547953	Missense_Mutation	novel	D4305G	0.11
BLCA	chr2	32597895	Missense_Mutation	novel	S4586L	0.35
BLCA	chr2	32599742	Missense_Mutation	novel	L4612V	0.5
BLCA	chr2	32505145	Missense_Mutation	novel	L3214F	0.33
BLCA	chr2	32499659	Missense_Mutation	novel	E2861K	0.16
BLCA	chr2	32607477	Missense_Mutation	novel	L4698R	0.22
BLCA	chr2	32529692	Missense_Mutation	novel	T3988A	0.08
BLCA	chr2	32487659	Missense_Mutation	novel	P2609L	0.09
BLCA	chr2	32491514	Missense_Mutation	NA	L2766V	0.4
BLCA	chr2	32515303	Missense_Mutation	NA	D3628H	0.42
BLCA	chr2	32448809	Missense_Mutation	NA	S1500N	0.21
BLCA	chr2	32401382	Missense_Mutation	NA	M418I	0.53
BLCA	chr2	32513002	Missense_Mutation	NA	M3472I	0.5
BLCA	chr2	32607522	Missense_Mutation	NA	R4713L	0.56
BLCA	chr2	32415554	Missense_Mutation	NA	E755K	0.15
BLCA	chr2	32518383	Nonsense_Mutation	NA	Q3827*	0.15
BLCA	chr2	32545664	Missense_Mutation	NA	S4205L	0.17
BLCA	chr2	32499726	Missense_Mutation	novel	S2883L	0.07
BLCA	chr2	32508065	Silent	rs761498168	L3262L	0.16
BLCA	chr2	32501837	Missense_Mutation	novel	M3052I	0.32
BLCA	chr2	32617794	Missense_Mutation	novel	D4822N	0.19
BLCA	chr2	32599808	Missense_Mutation	novel	Q4634E	0.29
BRCA	chr2	32477551	Missense_Mutation	NA	C2346S	0.27
BRCA	chr2	32388807	Missense_Mutation	novel	I235L	0.11
BRCA	chr2	32597925	Missense_Mutation	NA	S4596I	0.49
BRCA	chr2	32545805	Missense_Mutation	NA	S4252F	0.15
BRCA	chr2	32448862	Frame_Shift_Del	NA	*N1519Mfs61**	0.4
BRCA	chr2	32469463	Silent	novel	L2066L	0.05
BRCA	chr2	32515561	Missense_Mutation	NA	A3714T	0.27
BRCA	chr2	32611497	Missense_Mutation	NA	C4770Y	0.28
BRCA	chr2	32487784	Nonsense_Mutation	novel	Q2651*	0.06
BRCA	chr2	32493662	Silent	novel	T2821T	0.28
BRCA	chr2	32415577	Silent	NA	Q762Q	0.15
BRCA	chr2	32549437	Missense_Mutation	NA	S4367F	0.17
BRCA	chr2	32491536	Missense_Mutation	novel	G2773E	0.06
BRCA	chr2	32518380	Missense_Mutation	novel	L3826V	0.09
BRCA	chr2	32463242	Missense_Mutation	rs769761198	T1601I	0.16
BRCA	chr2	32470269	Missense_Mutation	novel	Q2150L	0.2
BRCA	chr2	32430939	Missense_Mutation	NA	T1033A	0.32
BRCA	chr2	32599873	Silent	rs775744828	F4655F	0.35
BRCA	chr2	32525613	Missense_Mutation	novel	H3969Y	0.09
BRCA	chr2	32518814	Splice_Region	novel		0.1
BRCA	chr2	32611447	Splice_Site	NA	X4754_splice	0.14
BRCA	chr2	32502845	Silent	novel	L3086L	0.15
BRCA	chr2	32518917	Missense_Mutation	NA	T3865I	0.15
BRCA	chr2	32501798	Missense_Mutation	rs769916738	I3039M	0.09
BRCA	chr2	32501824	Missense_Mutation	NA	S3048F	0.12
BRCA	chr2	32545664	Missense_Mutation	NA	S4205L	0.27
BRCA	chr2	32575275	Missense_Mutation	NA	E4422K	0.17
BRCA	chr2	32611497	Missense_Mutation	novel	C4770F	0.21
BRCA	chr2	32473193	Missense_Mutation	NA	R2225I	0.16
BRCA	chr2	32429244	Missense_Mutation	NA	S991P	0.16
BRCA	chr2	32545788	Silent	rs145269315	L4246L	0.14
BRCA	chr2	32415481	Nonsense_Mutation	novel	*C732Vfs4**	0.06
BRCA	chr2	32430867	Missense_Mutation	novel	V1009F	0.09
BRCA	chr2	32603077	Frame_Shift_Ins	novel	*L4689Sfs24**	0.06
BRCA	chr2	32545836	In_Frame_Ins	novel	P4262_N4263insFYSIIL	0.08
BRCA	chr2	32406535	Silent	NA	H485H	0.38
BRCA	chr2	32469401	Missense_Mutation	NA	S2045F	0.15
BRCA	chr2	32543533	Missense_Mutation	NA	G4195V	0.4
BRCA	chr2	32518348	Missense_Mutation	novel	L3815W	0.09
BRCA	chr2	32415599	In_Frame_Del	NA	N770del	0.53
BRCA	chr2	32513097	Missense_Mutation	NA	S3504N	0.2
BRCA	chr2	32599754	Missense_Mutation	NA	P4616T	0.19
BRCA	chr2	32510532	Missense_Mutation	novel	N3415S	0.07
BRCA	chr2	32531368	Frame_Shift_Del	novel	L4037*	0.09
BRCA	chr2	32377642	Missense_Mutation	NA	I127T	0.4
BRCA	chr2	32433739	Missense_Mutation	novel	T1115S	0.08
CESC	chr2	32357372	In_Frame_Del	novel	S72_H76del	0.67
CESC	chr2	32415864	Missense_Mutation	NA	S858L	0.31
CESC	chr2	32441407	Missense_Mutation	rs370410054	Q1297E	0.11
CESC	chr2	32493617	Silent	novel	Q2806Q	0.18
CESC	chr2	32547991	Nonsense_Mutation	novel	E4318*	0.2
CESC	chr2	32469486	Missense_Mutation	NA	K2073N	0.38
CESC	chr2	32618154	3'UTR	novel		0.25
CESC	chr2	32442136	Frame_Shift_Ins	novel	*D1340Ifs4**	0.09
CESC	chr2	32442138	Frame_Shift_Ins	novel	*D1340Afs3**	0.09
CESC	chr2	32547858	Silent	rs368206423	V4273V	0.31
CESC	chr2	32499561	Missense_Mutation	rs776176230	T2828I	0.28
CESC	chr2	32467940	Missense_Mutation	rs766401012	R1870K	0.67
CESC	chr2	32518923	Missense_Mutation	NA	S3867L	0.18
CESC	chr2	32453851	Silent	NA	F1554F	0.15
CESC	chr2	32435530	Silent	rs775264551	P1148P	0.39
CESC	chr2	32445631	Missense_Mutation	novel	D1483N	0.46
CESC	chr2	32463257	Missense_Mutation	rs773928708	S1606L	0.36
CESC	chr2	32468727	Missense_Mutation	novel	R2024H	0.49
CESC	chr2	32478756	Missense_Mutation	rs764261702	I2397T	0.42
CESC	chr2	32618573	3'UTR	novel		0.14
CESC	chr2	32618677	3'UTR	novel		0.27
CESC	chr2	32543526	Missense_Mutation	novel	D4193H	0.17
CESC	chr2	32357090	5'UTR	novel		0.26
CESC	chr2	32513061	Missense_Mutation	novel	S3492C	0.38
CESC	chr2	32415414	Missense_Mutation	novel	S708C	0.27
CESC	chr2	32543263	Missense_Mutation	novel	S4105F	0.24
CESC	chr2	32401330	Missense_Mutation	novel	A401V	0.21
CESC	chr2	32415078	Missense_Mutation	novel	R596K	0.11
CESC	chr2	32532181	Intron	NA		0.31
CESC	chr2	32388860	Silent	rs750051821	A252A	0.85
CESC	chr2	32595071	Missense_Mutation	novel	M4513I	0.36
CESC	chr2	32357141	5'UTR	novel		0.62
CESC	chr2	32515584	Missense_Mutation	novel	H3721Q	0.3
CHOL	chr2	32442116	Silent	novel	L1332L	0.43
CHOL	chr2	32453868	Missense_Mutation	NA	L1560R	0.4
CHOL	chr2	32499905	Missense_Mutation	novel	R2943G	0.32
CHOL	chr2	32388892	Missense_Mutation	novel	L263S	0.33
COAD	chr2	32415651	Missense_Mutation	NA	N787T	0.47
COAD	chr2	32485735	Missense_Mutation	rs368623523	A2597T	0.34
COAD	chr2	32508077	Missense_Mutation	NA	K3266N	0.42
COAD	chr2	32575334	Missense_Mutation	NA	K4441N	0.37
COAD	chr2	32463258	Silent	rs761024593	S1606S	0.31
COAD	chr2	32513095	Frame_Shift_Del	novel	*S3504Mfs5**	0.15
COAD	chr2	32415747	Missense_Mutation	novel	N819T	0.09
COAD	chr2	32433742	Missense_Mutation	novel	N1116T	0.35
COAD	chr2	32464713	Missense_Mutation	novel	V1716I	0.34
COAD	chr2	32467534	Missense_Mutation	NA	R1789I	0.36
COAD	chr2	32478661	Silent	rs371974273	T2365T	0.25
COAD	chr2	32499812	Missense_Mutation	novel	E2912K	0.26
COAD	chr2	32617878	Nonsense_Mutation	NA	E4850*	0.38
COAD	chr2	32476268	Frame_Shift_Del	novel	*I2261Yfs13**	0.3
COAD	chr2	32515217	Missense_Mutation	NA	A3599V	0.11
COAD	chr2	32463309	Silent	novel	A1623A	0.41
COAD	chr2	32617878	Nonsense_Mutation	NA	E4850*	0.39
COAD	chr2	32380187	Missense_Mutation	NA	V181A	0.11
COAD	chr2	32442171	Missense_Mutation	NA	L1351I	0.4
COAD	chr2	32415461	Missense_Mutation	NA	K724Q	0.24
COAD	chr2	32415949	Missense_Mutation	rs747004451	K886N	0.45
COAD	chr2	32529798	Missense_Mutation	NA	S4023Y	0.37
COAD	chr2	32575200	Missense_Mutation	NA	E4397K	0.47
COAD	chr2	32433713	Silent	NA	F1106F	0.21
COAD	chr2	32595050	Missense_Mutation	novel	E4506D	0.06
COAD	chr2	32543238	Splice_Region	novel	*S4099Rfs18**	0.44
COAD	chr2	32464593	Missense_Mutation	NA	V1676M	0.26
COAD	chr2	32529765	Missense_Mutation	NA	V4012A	0.17
COAD	chr2	32594062	Splice_Site	NA	X4501_splice	0.16
COAD	chr2	32499736	Silent	rs565916832	S2886S	0.26
COAD	chr2	32518851	Missense_Mutation	novel	V3843D	0.07
COAD	chr2	32479474	Missense_Mutation	NA	A2422V	0.09
COAD	chr2	32442431	Frame_Shift_Del	NA	*R1406Dfs3**	0.35
COAD	chr2	32595034	Frame_Shift_Del	NA	*K4503Nfs11**	0.09
COAD	chr2	32469453	Silent	NA	L2062L	0.35
COAD	chr2	32380244	Frame_Shift_Ins	NA	*N202Kfs5**	0.34
COAD	chr2	32501837	Missense_Mutation	rs758975775	M3052I	0.46
COAD	chr2	32442131	Frame_Shift_Del	novel	*T1339Qfs21**	0.44
COAD	chr2	32464723	Missense_Mutation	novel	V1719A	0.24
COAD	chr2	32529707	Nonsense_Mutation	novel	R3993*	0.24
COAD	chr2	32508100	Missense_Mutation	NA	V3274A	0.48
COAD	chr2	32482474	Missense_Mutation	NA	T2530S	0.3
COAD	chr2	32515127	Missense_Mutation	NA	P3569H	0.2
COAD	chr2	32441372	Missense_Mutation	rs775469848	R1285H	0.17
COAD	chr2	32442383	Missense_Mutation	novel	V1389A	0.09
COAD	chr2	32575191	Missense_Mutation	NA	A4394S	0.08
COAD	chr2	32477414	Missense_Mutation	rs768271303	R2300H	0.23
COAD	chr2	32431053	Frame_Shift_Del	novel	*A1071Lfs23**	0.39
COAD	chr2	32499591	Missense_Mutation	novel	K2838T	0.56
COAD	chr2	32595034	Frame_Shift_Del	NA	*K4503Nfs11**	0.35
COAD	chr2	32515507	Missense_Mutation	rs752759367	S3696G	0.41
COAD	chr2	32529681	Missense_Mutation	NA	A3984V	0.3
COAD	chr2	32416093	Silent	NA	T934T	0.03
COAD	chr2	32401379	Frame_Shift_Ins	NA	*M418Nfs8**	0.25
COAD	chr2	32416027	Frame_Shift_Del	novel	*I914Yfs2**	0.07
COAD	chr2	32575159	Missense_Mutation	novel	L4383P	0.32
COAD	chr2	32471126	Splice_Site	NA	X2198_splice	0.11
COAD	chr2	32478733	Silent	NA	G2389G	0.13
COAD	chr2	32508096	Missense_Mutation	NA	E3273K	0.11
COAD	chr2	32515214	Missense_Mutation	novel	N3598T	0.11
COAD	chr2	32464770	Frame_Shift_Del	NA	*P1736Qfs17**	0.37
COAD	chr2	32415394	Silent	rs142938281	P701P	0.2
COAD	chr2	32464734	Missense_Mutation	rs776666613	E1723K	0.32
COAD	chr2	32470200	Missense_Mutation	NA	R2127I	0.3
COAD	chr2	32487769	Frame_Shift_Ins	novel	*S2648Ffs25**	0.08
COAD	chr2	32525596	Missense_Mutation	novel	P3963Q	0.34
COAD	chr2	32575237	Missense_Mutation	novel	V4409A	0.36
COAD	chr2	32617878	Nonsense_Mutation	NA	E4850*	0.43
COAD	chr2	32436158	Missense_Mutation	NA	T1202M	0.32
COAD	chr2	32515171	Frame_Shift_Del	NA	*K3585Sfs8**	0.32
COAD	chr2	32392152	Splice_Site	novel	X317_splice	0.27
COAD	chr2	32476317	Missense_Mutation	rs749532024	Q2275H	0.04
COAD	chr2	32531537	Nonsense_Mutation	NA	E4093*	0.17
COAD	chr2	32607558	Missense_Mutation	NA	R4725Q	0.24
COAD	chr2	32515146	Silent	rs374767916	H3575H	0.27
COAD	chr2	32518837	In_Frame_Ins	novel	N3838_A3839insLDM	0.09
COAD	chr2	32524959	Nonsense_Mutation	novel	K3899_E3900ins*	0.03
COAD	chr2	32525496	In_Frame_Ins	novel	A3930delinsENRNVP	0.04
COAD	chr2	32599759	Silent	NA	A4617A	0.19
COAD	chr2	32543339	Silent	novel	Y4130Y	0.39
COAD	chr2	32448922	Missense_Mutation	novel	L1538I	0.29
DLBC	chr2	32548008	Silent	novel	L4323L	0.41
ESCA	chr2	32510529	Missense_Mutation	novel	L3414S	0.08
ESCA	chr2	32532183	Intron	novel		0.36
ESCA	chr2	32543209	Splice_Site	novel	X4098_splice	0.14
ESCA	chr2	32415414	Missense_Mutation	novel	S708F	0.28
ESCA	chr2	32468555	Missense_Mutation	novel	D1967H	0.21
ESCA	chr2	32531436	Frame_Shift_Del	novel	*E4059Gfs23**	0.49
ESCA	chr2	32618674	3'UTR	novel		0.23
ESCA	chr2	32415069	Missense_Mutation	novel	G593D	0.2
ESCA	chr2	32531435	Nonsense_Mutation	novel	E4059*	0.41
ESCA	chr2	32448816	Silent	rs150651833	P1502P	0.31
ESCA	chr2	32401306	Missense_Mutation	rs545030293	S393L	0.43
ESCA	chr2	32515418	Missense_Mutation	rs759663407	R3666H	0.38
ESCA	chr2	32470268	Nonsense_Mutation	novel	Q2150*	0.08
ESCA	chr2	32436183	Missense_Mutation	novel	K1210N	0.11
GBM	chr2	32482512	Silent	novel	I2542I	0.11
GBM	chr2	32502830	Missense_Mutation	novel	L3081F	0.27
GBM	chr2	32515339	Missense_Mutation	rs112352145	A3640T	0.1
GBM	chr2	32549344	Missense_Mutation	NA	S4336N	0.32
GBM	chr2	32470288	Missense_Mutation	NA	H2156Q	0.31
GBM	chr2	32415824	Missense_Mutation	novel	K845Q	0.55
GBM	chr2	32448851	Missense_Mutation	novel	G1514D	0.26
GBM	chr2	32468599	Silent	novel	Q1981Q	0.54
GBM	chr2	32499868	Silent	novel	V2930V	0.05
GBM	chr2	32545767	Missense_Mutation	novel	L4239F	0.58
GBM	chr2	32380279	Missense_Mutation	novel	K212E	0.41
GBM	chr2	32549460	Frame_Shift_Del	novel	*S4375Lfs63**	0.05
GBM	chr2	32469413	Missense_Mutation	novel	V2049D	0.05
GBM	chr2	32415032	Frame_Shift_Ins	novel	*S581Cfs4**	0.05
GBM	chr2	32415260	Missense_Mutation	novel	L657V	0.39
GBM	chr2	32433775	Missense_Mutation	novel	N1127T	0.67
GBM	chr2	32442386	Missense_Mutation	rs150284362	R1390H	0.21
GBM	chr2	32531392	Missense_Mutation	novel	E4044D	0.3
GBM	chr2	32545703	Missense_Mutation	rs775201281	R4218H	0.28
GBM	chr2	32595066	Missense_Mutation	novel	A4512S	0.58
GBM	chr2	32599770	Missense_Mutation	novel	Y4621C	0.16
GBM	chr2	32515499	Frame_Shift_Del	novel	*G3694Afs6**	0.07
GBM	chr2	32512942	Silent	novel	A3452A	0.15
GBM	chr2	32509751	Missense_Mutation	novel	R3332W	0.29
GBM	chr2	32415589	Missense_Mutation	novel	L766F	0.05
GBM	chr2	32401231	Missense_Mutation	novel	L368W	0.1
GBM	chr2	32575308	Missense_Mutation	novel	V4433I	0.22
HNSC	chr2	32357122	5'UTR	novel		0.8
HNSC	chr2	32442107	Silent	novel	E1329E	0.18
HNSC	chr2	32415674	Missense_Mutation	novel	N795H	0.47
HNSC	chr2	32525630	Splice_Site	novel	X3974_splice	0.17
HNSC	chr2	32510568	Missense_Mutation	novel	S3427Y	0.09
HNSC	chr2	32547935	Missense_Mutation	novel	S4299F	0.21
HNSC	chr2	32499699	Nonsense_Mutation	novel	S2874*	0.27
HNSC	chr2	32503209	Missense_Mutation	novel	E3158K	0.28
HNSC	chr2	32401294	Missense_Mutation	novel	S389C	0.15
HNSC	chr2	32467704	Missense_Mutation	novel	D1846N	0.18
HNSC	chr2	32599883	Missense_Mutation	NA	L4659F	0.55
HNSC	chr2	32597820	Missense_Mutation	novel	S4561F	0.19
HNSC	chr2	32380221	Silent	novel	F192F	0.2
HNSC	chr2	32464647	Missense_Mutation	novel	I1694F	0.31
HNSC	chr2	32482527	Nonsense_Mutation	novel	*P2547_P2548insNRTTKIFY**	0.07
HNSC	chr2	32508160	Nonsense_Mutation	novel	S3294*	0.1
HNSC	chr2	32473129	Frame_Shift_Ins	novel	N2205*	0.26
HNSC	chr2	32476298	Missense_Mutation	novel	Y2269C	0.4
HNSC	chr2	32525604	Missense_Mutation	novel	H3966Y	0.21
HNSC	chr2	32503117	Missense_Mutation	novel	S3127L	0.36
HNSC	chr2	32442211	Missense_Mutation	rs754429641	S1364L	0.11
HNSC	chr2	32515688	Missense_Mutation	rs138598333	R3756H	0.19
HNSC	chr2	32545696	Missense_Mutation	novel	V4216F	0.24
HNSC	chr2	32415635	Missense_Mutation	novel	G782C	0.18
HNSC	chr2	32463373	Nonsense_Mutation	novel	Q1645*	0.21
HNSC	chr2	32416066	Frame_Shift_Del	novel	*V926Gfs3**	0.15
HNSC	chr2	32607454	Splice_Site	novel	X4691_splice	0.14
HNSC	chr2	32543359	Missense_Mutation	rs777191070	A4137V	0.19
HNSC	chr2	32505115	Nonsense_Mutation	novel	E3204*	0.12
HNSC	chr2	32464608	Missense_Mutation	novel	V1681M	0.38
HNSC	chr2	32513058	In_Frame_Del	novel	S3492del	0.38
HNSC	chr2	32415648	Nonsense_Mutation	NA	S786*	0.2
HNSC	chr2	32388771	Missense_Mutation	novel	L223F	0.25
HNSC	chr2	32501805	Missense_Mutation	novel	T3042A	0.29
KICH	chr2	32415977	Missense_Mutation	novel	D896N	0.07
KICH	chr2	32488666	Missense_Mutation	novel	I2683V	0.17
KIRC	chr2	32464710	Missense_Mutation	NA	A1715S	0.21
KIRC	chr2	32406525	Missense_Mutation	rs550400928	S482N	0.18
KIRC	chr2	32509855	Missense_Mutation	NA	L3366F	0.33
KIRC	chr2	32415648	Nonsense_Mutation	NA	S786*	0.13
KIRC	chr2	32380168	Missense_Mutation	NA	S175P	0.46
KIRC	chr2	32468609	Missense_Mutation	NA	N1985Y	0.31
KIRC	chr2	32448891	Silent	NA	V1527V	0.19
KIRC	chr2	32430959	Silent	novel	S1039S	0.25
KIRC	chr2	32392150	Nonsense_Mutation	novel	P318*	0.07
KIRC	chr2	32415857	Missense_Mutation	rs768566974	I856V	0.17
KIRC	chr2	32467949	Missense_Mutation	NA	I1873S	0.27
KIRC	chr2	32499601	Missense_Mutation	novel	E2841D	0.21
KIRP	chr2	32529758	Missense_Mutation	rs748637705	S4010P	0.44
KIRP	chr2	32515254	Silent	novel	A3611A	0.38
KIRP	chr2	32415238	Missense_Mutation	novel	M649I	0.53
KIRP	chr2	32430986	Missense_Mutation	NA	E1048D	0.31
KIRP	chr2	32406509	Missense_Mutation	novel	L477M	0.44
KIRP	chr2	32501778	Missense_Mutation	NA	G3033R	0.21
KIRP	chr2	32515092	Frame_Shift_Ins	novel	*L3560Cfs21**	0.21
KIRP	chr2	32442208	Missense_Mutation	NA	H1363P	0.55
KIRP	chr2	32401511	Nonsense_Mutation	NA	Q436*	0.36
KIRP	chr2	32477535	Silent	novel	L2340L	0.37
LAML	chr2	32505040	Missense_Mutation	novel	A3179T	0.03
LAML	chr2	32414815	Silent	novel	T508T	0.04
LAML	chr2	32415102	Missense_Mutation	novel	E604A	0.05
LGG	chr2	32481339	Frame_Shift_Del	novel	*L2477Wfs15**	0.1
LGG	chr2	32388759	Missense_Mutation	novel	V219F	0.18
LGG	chr2	32463379	Nonsense_Mutation	novel	Q1647*	0.37
LGG	chr2	32477392	Missense_Mutation	novel	R2293C	0.26
LGG	chr2	32510619	Missense_Mutation	novel	P3444H	0.07
LGG	chr2	32515208	Missense_Mutation	novel	S3596F	0.31
LIHC	chr2	32543452	Missense_Mutation	novel	P4168L	0.13
LIHC	chr2	32525524	Missense_Mutation	novel	R3939K	0.06
LIHC	chr2	32481361	Missense_Mutation	novel	D2484H	0.52
LIHC	chr2	32429230	Missense_Mutation	NA	K986T	0.47
LIHC	chr2	32617785	Missense_Mutation	novel	P4819T	0.37
LIHC	chr2	32401347	Frame_Shift_Del	novel	*G407Efs12**	0.07
LIHC	chr2	32388825	Frame_Shift_Del	novel	I242*	0.2
LIHC	chr2	32501740	Missense_Mutation	NA	H3020P	0.31
LIHC	chr2	32525577	Missense_Mutation	NA	N3957H	0.31
LIHC	chr2	32415957	Missense_Mutation	NA	F889S	0.21
LIHC	chr2	32401617	Missense_Mutation	NA	G471E	0.11
LIHC	chr2	32467735	Missense_Mutation	NA	M1856T	0.17
LIHC	chr2	32467729	Missense_Mutation	novel	R1854I	0.07
LIHC	chr2	32436099	Silent	novel	L1182L	0.31
LIHC	chr2	32470185	Missense_Mutation	novel	S2122C	0.43
LIHC	chr2	32464696	Missense_Mutation	novel	T1710S	0.42
LIHC	chr2	32499607	Silent	novel	T2843T	0.33
LIHC	chr2	32499608	Silent	novel	L2844L	0.35
LIHC	chr2	32549311	Splice_Site	novel	X4326_splice	0.39
LIHC	chr2	32377638	Missense_Mutation	NA	V126F	0.24
LIHC	chr2	32597930	Missense_Mutation	novel	F4598V	0.21
LIHC	chr2	32478753	Missense_Mutation	novel	D2396G	0.11
LIHC	chr2	32499608	Silent	novel	L2844L	0.34
LUAD	chr2	32448794	Splice_Site	NA	X1495_splice	0.78
LUAD	chr2	32439658	Nonsense_Mutation	novel	S1261*	0.33
LUAD	chr2	32493641	Missense_Mutation	novel	K2814N	0.17
LUAD	chr2	32515607	Missense_Mutation	rs771309177	H3729R	0.55
LUAD	chr2	32499747	Missense_Mutation	NA	R2890L	0.37
LUAD	chr2	32414931	Missense_Mutation	novel	S547F	0.15
LUAD	chr2	32490082	Missense_Mutation	NA	N2713Y	0.27
LUAD	chr2	32377680	Missense_Mutation	NA	L140F	0.16
LUAD	chr2	32502794	Splice_Site	NA	X3070_splice	0.1
LUAD	chr2	32442084	Missense_Mutation	NA	L1322I	0.17
LUAD	chr2	32401309	Missense_Mutation	NA	G394E	0.16
LUAD	chr2	32415745	Missense_Mutation	novel	R818S	0.17
LUAD	chr2	32515191	Silent	novel	S3590S	0.11
LUAD	chr2	32611566	Missense_Mutation	NA	H4793R	0.31
LUAD	chr2	32415104	Missense_Mutation	novel	Q605E	0.3
LUAD	chr2	32433650	Frame_Shift_Ins	novel	*W1086Lfs3**	0.38
LUAD	chr2	32515203	Silent	novel	D3594D	0.17
LUAD	chr2	32415422	Frame_Shift_Del	novel	*K712Sfs9**	0.29
LUAD	chr2	32595128	Missense_Mutation	novel	M4532I	0.17
LUAD	chr2	32510612	Missense_Mutation	NA	Q3442E	0.06
LUAD	chr2	32518275	Missense_Mutation	rs774325819	T3791A	0.26
LUAD	chr2	32415588	Missense_Mutation	novel	L766W	0.16
LUAD	chr2	32490134	Missense_Mutation	novel	T2730R	0.22
LUAD	chr2	32442160	Frame_Shift_Ins	novel	*H1347Qfs14**	0.07
LUAD	chr2	32442161	In_Frame_Ins	novel	H1347_A1348insK	0.07
LUAD	chr2	32485701	Missense_Mutation	novel	M2585I	0.1
LUAD	chr2	32607566	Missense_Mutation	novel	D4728N	0.16
LUAD	chr2	32611514	Missense_Mutation	novel	D4776Y	0.09
LUAD	chr2	32414916	Missense_Mutation	novel	P542L	0.26
LUAD	chr2	32453821	Silent	novel	V1544V	0.06
LUAD	chr2	32499666	Missense_Mutation	novel	V2863A	0.08
LUAD	chr2	32545699	Missense_Mutation	novel	L4217F	0.05
LUAD	chr2	32388780	Missense_Mutation	novel	H226Y	0.13
LUAD	chr2	32469420	Missense_Mutation	novel	Q2051H	0.15
LUAD	chr2	32453874	In_Frame_Del	novel	E1562_P1565delinsA	0.1
LUAD	chr2	32509960	Silent	NA	L3401L	0.18
LUAD	chr2	32549322	Missense_Mutation	NA	S4329C	0.36
LUAD	chr2	32433695	Missense_Mutation	novel	M1100I	0.17
LUAD	chr2	32415193	Missense_Mutation	NA	S634R	0.32
LUAD	chr2	32593967	Nonsense_Mutation	novel	E4470*	0.13
LUAD	chr2	32547916	Missense_Mutation	NA	T4293P	0.42
LUAD	chr2	32448820	Missense_Mutation	novel	D1504Y	0.35
LUAD	chr2	32468015	Missense_Mutation	novel	H1895L	0.63
LUAD	chr2	32453931	Missense_Mutation	novel	R1581T	0.65
LUAD	chr2	32415762	Missense_Mutation	rs776144854	Y824C	0.46
LUAD	chr2	32502869	Silent	novel	A3094A	0.09
LUAD	chr2	32490075	Missense_Mutation	NA	W2710C	0.27
LUAD	chr2	32505098	Missense_Mutation	novel	S3198F	0.21
LUAD	chr2	32505099	Silent	novel	S3198S	0.21
LUAD	chr2	32464549	Missense_Mutation	NA	A1661V	0.43
LUAD	chr2	32501884	Missense_Mutation	NA	R3068I	0.31
LUAD	chr2	32543404	Missense_Mutation	NA	P4152R	0.09
LUAD	chr2	32543488	Missense_Mutation	NA	H4180L	0.35
LUAD	chr2	32549339	Silent	NA	V4334V	0.07
LUAD	chr2	32439631	Missense_Mutation	NA	Q1252P	0.19
LUAD	chr2	32469489	Missense_Mutation	NA	I2074M	0.27
LUAD	chr2	32499626	Missense_Mutation	novel	V2850I	0.31
LUAD	chr2	32464636	Missense_Mutation	novel	P1690Q	0.09
LUAD	chr2	32448926	Missense_Mutation	novel	S1539L	0.14
LUAD	chr2	32512989	Missense_Mutation	NA	R3468I	0.26
LUAD	chr2	32448915	Silent	novel	S1535S	0.15
LUAD	chr2	32549387	Silent	novel	G4350G	0.48
LUAD	chr2	32463304	Missense_Mutation	rs766311005	H1622Y	0.09
LUAD	chr2	32433715	Missense_Mutation	novel	K1107R	0.3
LUAD	chr2	32481379	Missense_Mutation	rs141491090	D2490Y	0.33
LUAD	chr2	32575359	Missense_Mutation	rs777387724	R4450C	0.61
LUAD	chr2	32415238	Missense_Mutation	NA	M649I	0.08
LUSC	chr2	32463309	Silent	rs781167841	A1623A	0.23
LUSC	chr2	32513016	Missense_Mutation	NA	P3477L	0.32
LUSC	chr2	32515282	Missense_Mutation	NA	E3621Q	0.22
LUSC	chr2	32515339	Missense_Mutation	NA	A3640S	0.22
LUSC	chr2	32525529	Missense_Mutation	NA	R3941W	0.19
LUSC	chr2	32513080	Silent	NA	A3498A	0.3
LUSC	chr2	32529676	Silent	NA	T3982T	0.24
LUSC	chr2	32597754	Missense_Mutation	rs372630615	T4539M	0.42
LUSC	chr2	32503074	Missense_Mutation	novel	T3113S	0.19
LUSC	chr2	32597815	Nonsense_Mutation	novel	Y4559*	0.25
LUSC	chr2	32442377	Missense_Mutation	rs770910769	D1387G	0.25
LUSC	chr2	32468767	Silent	novel	L2037L	0.28
LUSC	chr2	32479572	Nonsense_Mutation	novel	Q2455*	0.26
LUSC	chr2	32442167	Missense_Mutation	NA	Q1349H	0.51
LUSC	chr2	32501757	Missense_Mutation	NA	G3026W	0.28
LUSC	chr2	32441350	Missense_Mutation	novel	N1278Y	0.18
LUSC	chr2	32617746	Missense_Mutation	NA	E4806K	0.12
LUSC	chr2	32549444	Silent	NA	L4369L	0.22
LUSC	chr2	32448922	Missense_Mutation	novel	L1538F	0.24
LUSC	chr2	32500093	Silent	novel	A3005A	0.56
LUSC	chr2	32547935	Missense_Mutation	novel	S4299C	0.29
LUSC	chr2	32430976	Missense_Mutation	novel	C1045F	0.23
LUSC	chr2	32430977	Silent	novel	C1045C	0.23
LUSC	chr2	32518921	Silent	novel	L3866L	0.23
LUSC	chr2	32515410	Missense_Mutation	novel	K3663N	0.38
LUSC	chr2	32499866	Frame_Shift_Ins	novel	*V2930Gfs22**	0.05
LUSC	chr2	32415997	Missense_Mutation	novel	H902Q	0.34
LUSC	chr2	32415451	Silent	NA	L720L	0.36
LUSC	chr2	32515652	Missense_Mutation	novel	S3744Y	0.27
LUSC	chr2	32515321	Missense_Mutation	NA	L3634V	0.28
LUSC	chr2	32597965	Missense_Mutation	NA	M4609I	0.08
LUSC	chr2	32467641	Missense_Mutation	NA	E1825Q	0.2
LUSC	chr2	32531491	Missense_Mutation	novel	M4077I	0.11
LUSC	chr2	32509847	Missense_Mutation	NA	A3364S	0.24
LUSC	chr2	32500006	Silent	NA	S2976S	0.33
LUSC	chr2	32532236	Intron	novel		0.12
LUSC	chr2	32478759	Missense_Mutation	NA	S2398Y	0.15
LUSC	chr2	32505028	Missense_Mutation	rs201464207	T3175S	0.38
LUSC	chr2	32515122	Silent	novel	T3567T	0.2
LUSC	chr2	32414907	Missense_Mutation	novel	G539V	0.17
LUSC	chr2	32547965	Missense_Mutation	NA	A4309V	0.11
LUSC	chr2	32543328	Missense_Mutation	NA	E4127K	0.38
LUSC	chr2	32377605	Missense_Mutation	novel	V115M	0.23
LUSC	chr2	32468103	Missense_Mutation	novel	I1924M	0.18
LUSC	chr2	32525598	Missense_Mutation	NA	V3964L	0.73
LUSC	chr2	32595120	Missense_Mutation	NA	A4530S	0.38
LUSC	chr2	32549433	Missense_Mutation	NA	Q4366E	0.04
LUSC	chr2	32448916	Missense_Mutation	NA	D1536Y	0.34
LUSC	chr2	32548009	Silent	NA	L4324L	0.25
LUSC	chr2	32478722	Missense_Mutation	NA	L2386V	0.18
LUSC	chr2	32611575	Missense_Mutation	NA	A4796G	0.6
LUSC	chr2	32531357	Missense_Mutation	novel	H4033D	0.31
LUSC	chr2	32545675	Missense_Mutation	novel	L4209F	0.13
LUSC	chr2	32525608	Missense_Mutation	NA	L3967P	0.2
LUSC	chr2	32415106	Missense_Mutation	novel	Q605H	0.29
LUSC	chr2	32508159	Frame_Shift_Del	novel	*Q3295Lfs40**	0.05
LUSC	chr2	32501767	Missense_Mutation	novel	A3029V	0.21
LUSC	chr2	32529652	Splice_Region	novel	G3974G	0.26
LUSC	chr2	32380199	Missense_Mutation	novel	S185T	0.18
LUSC	chr2	32508213	Missense_Mutation	novel	V3312I	0.16
LUSC	chr2	32607547	Silent	NA	T4721T	0.22
LUSC	chr2	32439628	Missense_Mutation	NA	H1251L	0.16
LUSC	chr2	32415620	Frame_Shift_Del	novel	C777*	0.36
LUSC	chr2	32545658	Missense_Mutation	novel	S4203Y	0.37
LUSC	chr2	32463278	Missense_Mutation	novel	A1613D	0.37
LUSC	chr2	32401596	Missense_Mutation	novel	S464L	0.16
LUSC	chr2	32415166	Silent	rs761513610	R625R	0.13
LUSC	chr2	32415289	Missense_Mutation	novel	Q666H	0.15
LUSC	chr2	32415959	Missense_Mutation	novel	E890Q	0.1
LUSC	chr2	32607555	Missense_Mutation	NA	S4724F	0.12
MESO	chr2	32415214	Missense_Mutation	novel	K641N	0.31
MESO	chr2	32431060	Missense_Mutation	novel	H1073L	0.31
MESO	chr2	32464718	Silent	rs147771042	S1717S	0.29
OV	chr2	32485685	Missense_Mutation	novel	E2580A	0.05
OV	chr2	32463228	Silent	novel	G1596G	0.06
OV	chr2	32465119	Missense_Mutation	NA	Q1771E	0.25
OV	chr2	32477582	Missense_Mutation	novel	K2356R	0.06
OV	chr2	32436150	Silent	novel	G1199G	0.28
OV	chr2	32392104	Missense_Mutation	NA	R302T	0.23
OV	chr2	32415539	Silent	novel	R750R	0.06
OV	chr2	32509811	In_Frame_Del	novel	A3353_A3356del	0.2
OV	chr2	32415352	Nonsense_Mutation	NA	Y687*	0.2
OV	chr2	32414830	Silent	novel	L513L	0.16
OV	chr2	32503143	Missense_Mutation	novel	G3136S	0.16
OV	chr2	32543511	Missense_Mutation	novel	V4188L	0.08
OV	chr2	32543512	Missense_Mutation	novel	V4188A	0.08
OV	chr2	32435574	Missense_Mutation	NA	E1163A	0.3
OV	chr2	32512953	Nonsense_Mutation	novel	W3456*	0.06
OV	chr2	32545808	Missense_Mutation	NA	A4253V	0.14
OV	chr2	32463333	Silent	NA	L1631L	0.38
OV	chr2	32543438	Missense_Mutation	NA	L4163F	0.08
OV	chr2	32515062	Silent	novel	C3547C	0.08
OV	chr2	32415042	Missense_Mutation	novel	S584I	0.08
OV	chr2	32464540	Missense_Mutation	novel	T1658I	0.18
OV	chr2	32415264	Missense_Mutation	NA	H658L	0.42
OV	chr2	32463205	Missense_Mutation	novel	G1589R	0.33
OV	chr2	32464796	Missense_Mutation	novel	H1743Q	0.23
PAAD	chr2	32549457	Missense_Mutation	novel	S4374P	0.1
PAAD	chr2	32477387	Missense_Mutation	rs551174027	R2291H	0.25
PAAD	chr2	32515633	Missense_Mutation	novel	A3738T	0.14
PAAD	chr2	32357241	Missense_Mutation	novel	R27Q	0.4
PAAD	chr2	32549427	Missense_Mutation	novel	L4364F	0.09
PCPG	chr2	32594028	Missense_Mutation	NA	A4490V	0.06
PCPG	chr2	32467965	Nonsense_Mutation	novel	Y1878*	0.4
PRAD	chr2	32487658	Missense_Mutation	NA	P2609T	0.22
PRAD	chr2	32442385	Missense_Mutation	NA	R1390C	0.33
PRAD	chr2	32515143	Missense_Mutation	novel	H3574Q	0.25
PRAD	chr2	32599887	Missense_Mutation	NA	Y4660S	0.07
PRAD	chr2	32503238	Splice_Site	novel	X3167_splice	0.5
PRAD	chr2	32531498	Silent	novel	L4080L	0.71
READ	chr2	32597967	Missense_Mutation	NA	K4610T	0.46
READ	chr2	32431066	Missense_Mutation	NA	R1075Q	0.42
READ	chr2	32465153	Missense_Mutation	NA	R1782Q	0.21
READ	chr2	32471111	Missense_Mutation	NA	K2193N	0.25
READ	chr2	32477581	Missense_Mutation	NA	K2356E	0.27
READ	chr2	32479464	Missense_Mutation	NA	E2419K	0.2
READ	chr2	32508076	Missense_Mutation	NA	K3266T	0.24
READ	chr2	32515462	Missense_Mutation	rs773665748	D3681N	0.31
READ	chr2	32487687	Silent	NA	G2618G	0.05
READ	chr2	32481331	Missense_Mutation	NA	L2474M	0.04
READ	chr2	32442381	Silent	rs570884165	I1388I	0.22
READ	chr2	32477541	Frame_Shift_Del	novel	*D2343Tfs33**	0.1
READ	chr2	32442422	Missense_Mutation	NA	H1402R	0.21
READ	chr2	32477431	Nonsense_Mutation	NA	E2306*	0.22
READ	chr2	32508246	Missense_Mutation	NA	V3323I	0.18
READ	chr2	32594045	Missense_Mutation	NA	R4496W	0.33
READ	chr2	32467592	Silent	NA	T1808T	0.3
READ	chr2	32429165	Silent	NA	L964L	0.24
READ	chr2	32415296	Nonsense_Mutation	NA	E669*	0.43
READ	chr2	32442362	Missense_Mutation	rs777368785	R1382Q	0.3
READ	chr2	32501744	Missense_Mutation	NA	E3021D	0.45
READ	chr2	32524962	Nonsense_Mutation	NA	E3900*	0.36
READ	chr2	32545830	Silent	NA	R4260R	0.38
READ	chr2	32435530	Silent	rs775264551	P1148P	0.25
READ	chr2	32467642	Missense_Mutation	rs370894404	E1825G	0.34
READ	chr2	32499799	Silent	NA	K2907K	0.38
READ	chr2	32529735	Missense_Mutation	NA	I4002K	0.43
READ	chr2	32549470	Missense_Mutation	rs146403054	R4378Q	0.37
SARC	chr2	32549320	Missense_Mutation	novel	A4328V	0.31
SARC	chr2	32549321	Silent	rs756146093	A4328A	0.31
SARC	chr2	32618024	3'UTR	novel		0.26
SARC	chr2	32503236	Missense_Mutation	novel	G3167C	0.38
SARC	chr2	32380265	Missense_Mutation	novel	T207I	0.17
SARC	chr2	32618536	3'UTR	novel		0.41
SKCM	chr2	32469564	Silent	novel	V2099V	0.25
SKCM	chr2	32415151	Silent	NA	S620S	0.21
SKCM	chr2	32468732	Missense_Mutation	novel	I2026F	0.52
SKCM	chr2	32491529	Missense_Mutation	rs761264901	P2771S	0.32
SKCM	chr2	32515578	Missense_Mutation	rs770387826	L3719F	0.09
SKCM	chr2	32518855	Silent	novel	I3844I	0.21
SKCM	chr2	32464632	Missense_Mutation	NA	H1689Y	0.24
SKCM	chr2	32487734	Missense_Mutation	NA	S2634L	0.33
SKCM	chr2	32499736	Silent	rs565916832	S2886S	0.27
SKCM	chr2	32525494	Missense_Mutation	NA	S3929L	0.33
SKCM	chr2	32547980	Missense_Mutation	NA	R4314K	0.68
SKCM	chr2	32380215	Missense_Mutation	novel	D190E	0.59
SKCM	chr2	32430895	Missense_Mutation	novel	T1018I	0.21
SKCM	chr2	32430896	Silent	novel	T1018T	0.21
SKCM	chr2	32493582	Nonsense_Mutation	NA	R2795*	0.08
SKCM	chr2	32487719	Missense_Mutation	NA	L2629R	0.1
SKCM	chr2	32505167	Missense_Mutation	novel	K3221T	0.43
SKCM	chr2	32513056	Silent	NA	S3490S	0.25
SKCM	chr2	32543505	Nonsense_Mutation	NA	R4186*	0.19
SKCM	chr2	32442381	Silent	rs570884165	I1388I	0.25
SKCM	chr2	32401290	Missense_Mutation	NA	I388V	0.16
SKCM	chr2	32575190	Silent	NA	R4393R	0.35
SKCM	chr2	32499747	Missense_Mutation	NA	R2890Q	0.4
SKCM	chr2	32501744	Missense_Mutation	NA	E3021D	0.17
SKCM	chr2	32464751	Silent	NA	F1728F	0.36
SKCM	chr2	32599883	Missense_Mutation	NA	L4659F	0.33
SKCM	chr2	32481433	Missense_Mutation	NA	L2508F	0.77
SKCM	chr2	32499761	Missense_Mutation	novel	G2895R	0.36
SKCM	chr2	32499762	Missense_Mutation	novel	G2895E	0.36
SKCM	chr2	32603007	Frame_Shift_Del	novel	*C4666Vfs2**	0.23
SKCM	chr2	32415226	Silent	NA	I645I	0.39
SKCM	chr2	32599828	Silent	rs201179936	P4640P	0.37
SKCM	chr2	32599829	Missense_Mutation	novel	P4641S	0.36
SKCM	chr2	32543279	Silent	NA	K4110K	0.45
SKCM	chr2	32515479	Silent	NA	I3686I	0.33
SKCM	chr2	32603068	Silent	novel	T4685T	0.33
SKCM	chr2	32512999	Silent	NA	R3471R	0.37
SKCM	chr2	32441389	Missense_Mutation	rs763922153	R1291W	0.53
SKCM	chr2	32525615	Missense_Mutation	novel	H3969Q	0.41
SKCM	chr2	32414987	Missense_Mutation	rs770358856	C566S	0.22
SKCM	chr2	32515397	Missense_Mutation	NA	I3659N	0.37
SKCM	chr2	32547902	Missense_Mutation	NA	Y4288F	0.46
SKCM	chr2	32518389	Missense_Mutation	novel	P3829S	0.13
SKCM	chr2	32529749	Nonsense_Mutation	NA	K4007*	0.56
SKCM	chr2	32607537	Missense_Mutation	NA	P4718L	0.11
SKCM	chr2	32617938	3'UTR	novel		0.54
SKCM	chr2	32464653	Missense_Mutation	NA	P1696S	0.32
SKCM	chr2	32518880	Missense_Mutation	novel	H3853Y	0.48
SKCM	chr2	32429175	Missense_Mutation	NA	G968R	0.19
SKCM	chr2	32603059	Missense_Mutation	NA	N4682K	0.22
SKCM	chr2	32487650	Missense_Mutation	NA	S2606L	0.25
SKCM	chr2	32549407	Missense_Mutation	NA	P4357L	0.4
SKCM	chr2	32509984	Missense_Mutation	novel	S3409R	0.34
SKCM	chr2	32512956	Missense_Mutation	novel	V3457A	0.3
SKCM	chr2	32508231	Missense_Mutation	NA	P3318S	0.56
SKCM	chr2	32471074	Missense_Mutation	NA	Y2181C	0.25
SKCM	chr2	32499932	Missense_Mutation	NA	D2952N	0.12
SKCM	chr2	32607537	Missense_Mutation	NA	P4718L	0.33
SKCM	chr2	32415274	Silent	novel	G661G	0.28
SKCM	chr2	32441453	Missense_Mutation	rs749093978	S1312F	0.24
SKCM	chr2	32515258	Missense_Mutation	novel	L3613F	0.49
SKCM	chr2	32490051	Silent	NA	T2702T	0.47
SKCM	chr2	32377614	Nonsense_Mutation	NA	Q118*	0.52
SKCM	chr2	32415514	Missense_Mutation	NA	D741E	0.46
SKCM	chr2	32607474	Missense_Mutation	novel	S4697F	0.09
SKCM	chr2	32380193	Missense_Mutation	NA	I183N	0.63
STAD	chr2	32490044	Nonsense_Mutation	NA	S2700*	0.26
STAD	chr2	32464770	Frame_Shift_Del	NA	*P1736Qfs17**	0.15
STAD	chr2	32443555	Missense_Mutation	NA	N1435D	0.19
STAD	chr2	32401479	Missense_Mutation	NA	E425V	0.3
STAD	chr2	32468544	Missense_Mutation	NA	A1963V	0.2
STAD	chr2	32401223	Silent	novel	N365N	0.37
STAD	chr2	32401238	Silent	NA	V370V	0.17
STAD	chr2	32478798	Missense_Mutation	novel	M2411T	0.1
STAD	chr2	32575271	Silent	NA	G4420G	0.11
STAD	chr2	32499652	Silent	rs550913772	A2858A	0.15
STAD	chr2	32547990	Missense_Mutation	novel	E4317D	0.22
STAD	chr2	32515716	Silent	rs371274962	A3765A	0.54
STAD	chr2	32611553	In_Frame_Ins	novel	T4789_M4790insS	0.1
STAD	chr2	32482567	Missense_Mutation	rs144411884	V2561I	0.13
STAD	chr2	32448807	Frame_Shift_Ins	novel	*S1500Kfs5**	0.28
STAD	chr2	32415555	Missense_Mutation	NA	E755A	0.26
STAD	chr2	32490085	Missense_Mutation	NA	T2714P	0.36
STAD	chr2	32524962	Nonsense_Mutation	NA	E3900*	0.3
STAD	chr2	32529743	Missense_Mutation	NA	T4005P	0.37
STAD	chr2	32543482	Missense_Mutation	NA	R4178I	0.42
STAD	chr2	32595073	Missense_Mutation	NA	K4514T	0.3
STAD	chr2	32467548	Missense_Mutation	novel	D1794N	0.39
STAD	chr2	32482436	Missense_Mutation	rs776298375	S2517N	0.39
STAD	chr2	32515418	Missense_Mutation	rs759663407	R3666H	0.35
STAD	chr2	32543246	Silent	novel	S4099S	0.48
STAD	chr2	32469557	Missense_Mutation	NA	S2097F	0.05
STAD	chr2	32401243	Missense_Mutation	novel	L372P	0.31
STAD	chr2	32415763	Nonsense_Mutation	novel	Y824*	0.25
STAD	chr2	32599769	Missense_Mutation	NA	Y4621N	0.14
STAD	chr2	32515688	Missense_Mutation	rs138598333	R3756H	0.06
STAD	chr2	32448835	Missense_Mutation	NA	D1509N	0.21
STAD	chr2	32478660	Missense_Mutation	rs766592234	T2365M	0.15
STAD	chr2	32599868	Nonsense_Mutation	NA	R4654*	0.25
STAD	chr2	32503141	Missense_Mutation	rs367580642	S3135C	0.45
STAD	chr2	32478691	Silent	NA	V2375V	0.14
STAD	chr2	32597936	Missense_Mutation	rs773885941	R4600C	0.65
STAD	chr2	32603072	Missense_Mutation	NA	S4687R	0.2
STAD	chr2	32416093	Silent	NA	T934T	0.19
STAD	chr2	32463274	Missense_Mutation	NA	A1612T	0.22
STAD	chr2	32453868	Missense_Mutation	NA	L1560P	0.09
STAD	chr2	32415012	Missense_Mutation	NA	T574K	0.11
STAD	chr2	32415394	Silent	rs142938281	P701P	0.32
STAD	chr2	32525574	Missense_Mutation	NA	A3956T	0.24
STAD	chr2	32549341	Missense_Mutation	novel	S4335T	0.07
STAD	chr2	32430936	Missense_Mutation	novel	E1032K	0.13
STAD	chr2	32445535	Missense_Mutation	NA	Y1451H	0.52
STAD	chr2	32439565	Missense_Mutation	novel	R1230I	0.22
STAD	chr2	32479527	Missense_Mutation	NA	A2440T	0.19
STAD	chr2	32525524	Frame_Shift_Del	novel	*R3941Gfs7**	0.15
STAD	chr2	32433692	Silent	NA	C1099C	0.28
STAD	chr2	32439556	Missense_Mutation	NA	V1227A	0.37
STAD	chr2	32442062	Splice_Region	novel		0.22
STAD	chr2	32465071	Frame_Shift_Del	novel	*G1756Vfs2**	0.23
STAD	chr2	32453903	Missense_Mutation	NA	S1572P	0.27
STAD	chr2	32525509	Missense_Mutation	rs766431375	R3934H	0.25
STAD	chr2	32531493	Missense_Mutation	NA	G4078D	0.11
STAD	chr2	32611461	Frame_Shift_Ins	novel	*Y4760Lfs6**	0.31
TGCT	chr2	32465093	Missense_Mutation	novel	A1762V	0.21
TGCT	chr2	32442413	Missense_Mutation	novel	S1399I	0.1
TGCT	chr2	32465078	Missense_Mutation	novel	S1757C	0.22
TGCT	chr2	32493658	Nonsense_Mutation	novel	S2820*	0.1
THCA	chr2	32467903	Missense_Mutation	novel	I1858F	0.17
THCA	chr2	32463236	Missense_Mutation	novel	S1599Y	0.09
THCA	chr2	32469559	Missense_Mutation	NA	N2098Y	0.25
THYM	chr2	32357197	Silent	novel	T12T	0.08
UCEC	chr2	32415216	Missense_Mutation	NA	A642V	0.47
UCEC	chr2	32442362	Missense_Mutation	rs777368785	R1382Q	0.34
UCEC	chr2	32467534	Missense_Mutation	NA	R1789I	0.35
UCEC	chr2	32479608	Missense_Mutation	NA	D2467Y	0.27
UCEC	chr2	32515759	Silent	NA	L3780L	0.23
UCEC	chr2	32618059	3'UTR	novel		0.33
UCEC	chr2	32415900	Missense_Mutation	rs764577645	R870Q	0.32
UCEC	chr2	32479614	Missense_Mutation	NA	T2469P	0.27
UCEC	chr2	32499628	Silent	rs373827659	V2850V	0.3
UCEC	chr2	32510581	Silent	rs144073331	T3431T	0.29
UCEC	chr2	32515440	Silent	rs144976631	C3673C	0.32
UCEC	chr2	32515583	Missense_Mutation	NA	H3721R	0.25
UCEC	chr2	32549477	Missense_Mutation	NA	D4380E	0.28
UCEC	chr2	32597868	Missense_Mutation	novel	R4577H	0.33
UCEC	chr2	32357199	Missense_Mutation	novel	V13A	0.09
UCEC	chr2	32401512	Missense_Mutation	novel	Q436P	0.37
UCEC	chr2	32467681	Missense_Mutation	novel	S1838I	0.43
UCEC	chr2	32501813	Frame_Shift_Ins	novel	*A3047Sfs33**	0.3
UCEC	chr2	32513147	Missense_Mutation	novel	L3521F	0.31
UCEC	chr2	32618199	3'UTR	novel		0.21
UCEC	chr2	32618808	3'UTR	novel		0.18
UCEC	chr2	32618677	3'UTR	novel		0.33
UCEC	chr2	32499747	Missense_Mutation	NA	R2890Q	0.25
UCEC	chr2	32395543	Silent	novel	C328C	0.39
UCEC	chr2	32415585	Missense_Mutation	novel	A765V	0.43
UCEC	chr2	32463246	Silent	novel	V1602V	0.41
UCEC	chr2	32478741	Missense_Mutation	novel	F2392S	0.06
UCEC	chr2	32481322	Missense_Mutation	novel	A2471T	0.1
UCEC	chr2	32493628	Missense_Mutation	novel	E2810A	0.46
UCEC	chr2	32515373	Missense_Mutation	novel	E3651A	0.33
UCEC	chr2	32547896	Missense_Mutation	NA	Q4286R	0.44
UCEC	chr2	32607579	Missense_Mutation	rs772472693	R4732Q	0.12
UCEC	chr2	32618005	3'UTR	novel		0.45
UCEC	chr2	32618884	3'UTR	novel		0.4
UCEC	chr2	32415990	Missense_Mutation	novel	L900R	0.43
UCEC	chr2	32618677	3'UTR	novel		0.5
UCEC	chr2	32415865	Silent	rs150163773	S858S	0.28
UCEC	chr2	32543419	Missense_Mutation	novel	S4157F	0.17
UCEC	chr2	32416054	Missense_Mutation	NA	E921D	0.29
UCEC	chr2	32597824	Silent	rs765590765	Q4562Q	0.05
UCEC	chr2	32415761	Missense_Mutation	novel	Y824H	0.38
UCEC	chr2	32465106	Silent	rs760068526	A1766A	0.45
UCEC	chr2	32415795	Missense_Mutation	NA	R835Q	0.26
UCEC	chr2	32431086	Missense_Mutation	rs201321733	D1082N	0.23
UCEC	chr2	32471016	Missense_Mutation	novel	V2162I	0.36
UCEC	chr2	32477386	Missense_Mutation	rs771264582	R2291C	0.24
UCEC	chr2	32442073	Missense_Mutation	rs778986518	R1318Q	0.31
UCEC	chr2	32468663	Missense_Mutation	novel	K2003Q	0.32
UCEC	chr2	32482549	Missense_Mutation	rs548738385	G2555R	0.33
UCEC	chr2	32525530	Missense_Mutation	novel	R3941K	0.32
UCEC	chr2	32414788	Silent	novel	E499E	0.48
UCEC	chr2	32445524	Missense_Mutation	novel	S1447Y	0.31
UCEC	chr2	32505149	Missense_Mutation	novel	P3215H	0.31
UCEC	chr2	32547863	Missense_Mutation	novel	S4275I	0.32
UCEC	chr2	32618681	3'UTR	novel		0.2
UCEC	chr2	32464734	Missense_Mutation	rs776666613	E1723K	0.49
UCEC	chr2	32439529	Missense_Mutation	novel	R1218H	0.04
UCEC	chr2	32493582	Nonsense_Mutation	NA	R2795*	0.04
UCEC	chr2	32545736	Missense_Mutation	NA	D4229G	0.17
UCEC	chr2	32467919	Missense_Mutation	rs776988218	R1863H	0.5
UCEC	chr2	32388915	Missense_Mutation	NA	G271R	0.3
UCEC	chr2	32439589	Missense_Mutation	NA	G1238V	0.26
UCEC	chr2	32468730	Missense_Mutation	NA	T2025N	0.09
UCEC	chr2	32499682	Silent	NA	H2868H	0.17
UCEC	chr2	32595121	Missense_Mutation	NA	A4530V	0.21
UCEC	chr2	32618009	3'UTR	novel		0.11
UCEC	chr2	32618011	3'UTR	novel		0.12
UCEC	chr2	32471047	Missense_Mutation	NA	V2172A	0.44
UCEC	chr2	32595033	Splice_Site	novel	X4501_splice	0.38
UCEC	chr2	32401569	Frame_Shift_Ins	novel	*W456Hfs9**	0.05
UCEC	chr2	32406514	Missense_Mutation	novel	E478D	0.11
UCEC	chr2	32415258	Missense_Mutation	NA	S656I	0.31
UCEC	chr2	32442156	Nonsense_Mutation	NA	E1346*	0.29
UCEC	chr2	32490104	Missense_Mutation	NA	C2720Y	0.16
UCEC	chr2	32499628	Silent	rs373827659	V2850V	0.06
UCEC	chr2	32499923	Missense_Mutation	NA	N2949H	0.22
UCEC	chr2	32508129	Missense_Mutation	rs374958918	R3284C	0.31
UCEC	chr2	32515318	Missense_Mutation	novel	S3633A	0.1
UCEC	chr2	32518830	Missense_Mutation	novel	R3836K	0.09
UCEC	chr2	32597845	Silent	rs144705632	A4569A	0.47
UCEC	chr2	32477387	Missense_Mutation	rs551174027	R2291H	0.28
UCEC	chr2	32482447	Missense_Mutation	NA	Y2521H	0.34
UCEC	chr2	32388858	Missense_Mutation	novel	A252T	0.2
UCEC	chr2	32431009	Missense_Mutation	novel	R1056M	0.22
UCEC	chr2	32525536	Missense_Mutation	novel	I3943T	0.2
UCEC	chr2	32575189	Missense_Mutation	rs772626434	R4393Q	0.27
UCEC	chr2	32388824	Missense_Mutation	novel	K240N	0.31
UCEC	chr2	32395574	Missense_Mutation	NA	E339K	0.18
UCEC	chr2	32500006	Silent	NA	S2976S	0.46
UCEC	chr2	32543428	Missense_Mutation	rs752318608	A4160V	0.43
UCEC	chr2	32594046	Missense_Mutation	rs557307604	R4496Q	0.61
UCEC	chr2	32415538	Silent	NA	L749L	0.56
UCEC	chr2	32415018	Missense_Mutation	novel	K576T	0.4
UCEC	chr2	32513141	Nonsense_Mutation	novel	Q3519delinsPSIKY**	0.07
UCEC	chr2	32416144	Silent	novel	R951R	0.27
UCEC	chr2	32545828	Nonsense_Mutation	NA	R4260*	0.45
UCEC	chr2	32469584	Missense_Mutation	rs148607215	S2106L	0.43
UCEC	chr2	32597845	Silent	rs144705632	A4569A	0.1
UCEC	chr2	32618895	3'UTR	novel		0.28
UCEC	chr2	32617782	Missense_Mutation	novel	D4818Y	0.25
UCEC	chr2	32618533	3'UTR	novel		0.5
UCEC	chr2	32357059	5'UTR	novel		0.09
UCEC	chr2	32380286	Missense_Mutation	novel	A214D	0.37
UCEC	chr2	32435584	Splice_Region	novel	Q1166Q	0.27
UCEC	chr2	32481364	Missense_Mutation	novel	L2485I	0.32
UCEC	chr2	32491440	Missense_Mutation	novel	A2741V	0.2
UCEC	chr2	32501881	Missense_Mutation	novel	G3067D	0.2
UCEC	chr2	32515531	Missense_Mutation	novel	G3704S	0.31
UCEC	chr2	32543517	Missense_Mutation	novel	G4190R	0.19
UCEC	chr2	32547984	Silent	novel	L4315L	0.38
UCEC	chr2	32549344	Missense_Mutation	novel	S4336I	0.25
UCEC	chr2	32618677	3'UTR	novel		0.51
UCEC	chr2	32508233	Silent	novel	P3318P	0.07
UCEC	chr2	32433771	Missense_Mutation	novel	K1126E	0.3
UCEC	chr2	32473124	Missense_Mutation	rs776988295	S2202N	0.43
UCEC	chr2	32508144	Missense_Mutation	novel	S3289G	0.28
UCEC	chr2	32515417	Missense_Mutation	rs61757639	R3666C	0.73
UCEC	chr2	32597936	Missense_Mutation	rs773885941	R4600C	0.34
UCEC	chr2	32618677	3'UTR	novel		0.38
UCEC	chr2	32478661	Silent	rs371974273	T2365T	0.5
UCEC	chr2	32468529	Missense_Mutation	NA	R1958Q	0.27
UCEC	chr2	32618542	3'UTR	novel		0.53
UCEC	chr2	32431001	Silent	novel	Q1053Q	0.44
UCEC	chr2	32531363	Missense_Mutation	novel	D4035Y	0.1
UCEC	chr2	32429263	Missense_Mutation	novel	P997H	0.19
UCEC	chr2	32467919	Missense_Mutation	rs776988218	R1863H	0.57
UCEC	chr2	32488665	Silent	novel	D2682D	0.31
UCEC	chr2	32490045	Silent	rs750223510	S2700S	0.47
UCEC	chr2	32499783	Missense_Mutation	rs200142371	R2902H	0.31
UCEC	chr2	32543321	Missense_Mutation	novel	Q4124H	0.28
UCEC	chr2	32599864	Silent	rs759888260	S4652S	0.31
UCEC	chr2	32603028	Missense_Mutation	NA	T4672M	0.45
UCEC	chr2	32617878	Nonsense_Mutation	NA	E4850*	0.5
UCEC	chr2	32618517	3'UTR	novel		0.47
UCEC	chr2	32618677	3'UTR	novel		0.36
UCEC	chr2	32414956	Silent	novel	K555K	0.5
UCEC	chr2	32415390	Missense_Mutation	novel	S700Y	0.49
UCEC	chr2	32442068	Silent	novel	V1316V	0.58
UCEC	chr2	32468726	Missense_Mutation	rs143036929	R2024C	0.43
UCEC	chr2	32499629	Missense_Mutation	novel	V2851I	0.5
UCEC	chr2	32503098	Missense_Mutation	novel	T3121A	0.38
UCEC	chr2	32515148	Missense_Mutation	novel	R3576K	0.42
UCEC	chr2	32401345	Missense_Mutation	novel	R406Q	0.48
UCEC	chr2	32501824	Missense_Mutation	novel	S3048Y	0.24
UCEC	chr2	32531411	Nonsense_Mutation	novel	E4051*	0.54
UCEC	chr2	32597750	Splice_Site	novel	X4538_splice	0.37
UCEC	chr2	32618582	3'UTR	novel		0.53
UCEC	chr2	32594046	Missense_Mutation	rs557307604	R4496Q	0.45
UCEC	chr2	32499893	Missense_Mutation	NA	E2939K	0.36
UCEC	chr2	32545768	Nonsense_Mutation	NA	E4240*	0.38
UCEC	chr2	32597883	Missense_Mutation	NA	A4582D	0.35
UCEC	chr2	32607579	Missense_Mutation	rs772472693	R4732Q	0.32
UCEC	chr2	32415514	Missense_Mutation	novel	D741E	0.47
UCEC	chr2	32388945	Splice_Site	novel	X280_splice	0.31
UCEC	chr2	32357455	Frame_Shift_Del	novel	*A100Pfs16**	0.43
UCEC	chr2	32388915	Missense_Mutation	NA	G271R	0.39
UCEC	chr2	32401618	Silent	NA	G471G	0.06
UCEC	chr2	32477397	Silent	novel	R2294R	0.43
UCEC	chr2	32478638	Missense_Mutation	novel	L2358I	0.5
UCEC	chr2	32508096	Missense_Mutation	NA	E3273K	0.48
UCEC	chr2	32525469	Missense_Mutation	novel	K3921E	0.52
UCEC	chr2	32595134	Missense_Mutation	novel	K4534N	0.36
UCEC	chr2	32618184	3'UTR	novel		0.41
UCEC	chr2	32468564	Frame_Shift_Ins	NA	*S1972Ffs18**	0.35
UCEC	chr2	32531407	Silent	novel	G4049G	0.39
UCEC	chr2	32549463	Missense_Mutation	novel	Y4376H	0.24
UCEC	chr2	32618677	3'UTR	novel		0.41
UCEC	chr2	32401233	Missense_Mutation	novel	S369P	0.07
UCEC	chr2	32468457	Missense_Mutation	rs147371379	R1934H	0.31
UCEC	chr2	32415725	Missense_Mutation	novel	I812L	0.18
UCEC	chr2	32499737	Missense_Mutation	rs755972507	V2887M	0.27
UCEC	chr2	32503129	Missense_Mutation	rs765094572	K3131T	0.46
UCEC	chr2	32518839	Missense_Mutation	novel	A3839V	0.43
UCEC	chr2	32524999	Missense_Mutation	novel	Y3912C	0.14
UCEC	chr2	32575188	Missense_Mutation	novel	R4393W	0.17
UCEC	chr2	32611574	Missense_Mutation	novel	A4796T	0.16
UCEC	chr2	32618154	3'UTR	novel		0.15
UCEC	chr2	32575200	Nonsense_Mutation	novel	E4397*	0.37
UCEC	chr2	32531428	Missense_Mutation	NA	I4056M	0.21
UCEC	chr2	32388904	Missense_Mutation	novel	R267H	0.47
UCEC	chr2	32442380	Missense_Mutation	NA	I1388S	0.33
UCEC	chr2	32500060	Missense_Mutation	novel	I2994M	0.38
UCEC	chr2	32501771	Missense_Mutation	novel	I3030M	0.3
UCEC	chr2	32607578	Nonsense_Mutation	NA	R4732*	0.33
UCEC	chr2	32508051	Missense_Mutation	NA	V3258F	0.23
UCEC	chr2	32448926	Nonsense_Mutation	novel	S1539*	0.16
UCEC	chr2	32401251	Missense_Mutation	novel	S375R	0.44
UCEC	chr2	32401501	Silent	novel	A432A	0.42
UCEC	chr2	32431066	Missense_Mutation	NA	R1075Q	0.33
UCEC	chr2	32464569	Missense_Mutation	novel	A1668S	0.49
UCEC	chr2	32575192	Missense_Mutation	novel	A4394V	0.26
UCEC	chr2	32401352	Missense_Mutation	NA	K408N	0.44
UCEC	chr2	32465152	Nonsense_Mutation	novel	R1782*	0.17
UCEC	chr2	32507984	Silent	novel	C3235C	0.57
UCEC	chr2	32593976	Nonsense_Mutation	novel	G4473*	0.35
UCEC	chr2	32549474	Silent	novel	N4379N	0.42
UCEC	chr2	32482490	Missense_Mutation	NA	P2535H	0.08
UCEC	chr2	32603004	Splice_Site	novel	X4665_splice	0.14
UCEC	chr2	32401352	Missense_Mutation	NA	K408N	0.3
UCEC	chr2	32415255	Missense_Mutation	NA	K655T	0.2
UCEC	chr2	32431066	Missense_Mutation	NA	R1075Q	0.11
UCEC	chr2	32433654	Missense_Mutation	NA	D1087N	0.25
UCEC	chr2	32442362	Missense_Mutation	rs777368785	R1382Q	0.46
UCEC	chr2	32510582	Missense_Mutation	NA	I3432L	0.23
UCEC	chr2	32543442	Missense_Mutation	NA	L4165I	0.22
UCEC	chr2	32401499	Missense_Mutation	novel	A432T	0.12
UCEC	chr2	32436055	Missense_Mutation	novel	L1168I	0.16
UCEC	chr2	32618164	3'UTR	novel		0.13
UCEC	chr2	32595033	Frame_Shift_Ins	rs749424971	*L4504Tfs3**	0.38
UCEC	chr2	32430998	Missense_Mutation	novel	E1052D	0.36
UCEC	chr2	32503130	Silent	novel	K3131K	0.27
UCEC	chr2	32515764	Missense_Mutation	novel	M3781I	0.31
UCEC	chr2	32531466	Missense_Mutation	novel	S4069L	0.26
UCEC	chr2	32603030	Missense_Mutation	novel	W4673R	0.35
UCEC	chr2	32607629	Missense_Mutation	novel	P4749T	0.36
UCEC	chr2	32513141	Nonsense_Mutation	novel	Q3519delinsPSIKY**	0.19
UCEC	chr2	32617725	Missense_Mutation	rs759980874	R4799C	0.39
UCEC	chr2	32395565	Missense_Mutation	NA	V336I	0.27
UCEC	chr2	32415795	Missense_Mutation	NA	R835Q	0.13
UCEC	chr2	32525509	Missense_Mutation	rs766431375	R3934H	0.33
UCEC	chr2	32545762	Missense_Mutation	NA	A4238T	0.33
UCEC	chr2	32357152	5'UTR	novel		0.33
UCEC	chr2	32464631	Silent	novel	I1688I	0.09
UCEC	chr2	32513010	Missense_Mutation	novel	M3475R	0.37
UCEC	chr2	32599873	Silent	rs775744828	F4655F	0.46
UCEC	chr2	32401569	Frame_Shift_Ins	novel	*W456Hfs9**	0.07
UCEC	chr2	32415195	In_Frame_Ins	novel	I635_K636insIRQLTFGAC	0.05
UCEC	chr2	32414838	Missense_Mutation	novel	P516L	0.21
UCEC	chr2	32415588	Missense_Mutation	novel	L766S	0.3
UCEC	chr2	32471076	Missense_Mutation	rs748895437	V2182M	0.35
UCEC	chr2	32433704	Silent	NA	H1103H	0.26
UCEC	chr2	32545721	Missense_Mutation	novel	T4224I	0.34
UCEC	chr2	32414900	Nonsense_Mutation	NA	E537*	0.25
UCEC	chr2	32415150	Missense_Mutation	NA	S620F	0.23
UCEC	chr2	32482566	Silent	rs564249634	S2560S	0.25
UCEC	chr2	32505094	Missense_Mutation	NA	W3197R	0.2
UCEC	chr2	32531546	Missense_Mutation	NA	Q4096K	0.21
UCEC	chr2	32575209	Missense_Mutation	rs775855234	R4400W	0.23
UCEC	chr2	32611516	Silent	NA	D4776D	0.21
UCEC	chr2	32445589	Missense_Mutation	novel	A1469S	0.06
UCEC	chr2	32510546	Missense_Mutation	NA	F3420V	0.33
UCEC	chr2	32515588	Frame_Shift_Ins	novel	*G3723Vfs11**	0.07
UCEC	chr2	32549470	Missense_Mutation	rs146403054	R4378Q	0.39
UCEC	chr2	32607578	Nonsense_Mutation	NA	R4732*	0.39
UCEC	chr2	32468513	Missense_Mutation	NA	A1953T	0.18
UCEC	chr2	32380237	Missense_Mutation	novel	D198Y	0.16
UCEC	chr2	32545819	Nonsense_Mutation	novel	*H4257Lfs3**	0.05
UCEC	chr2	32524962	Nonsense_Mutation	NA	E3900*	0.24
UCEC	chr2	32415223	Missense_Mutation	novel	K644N	0.56
UCEC	chr2	32463204	Silent	rs185403838	F1588F	0.26
UCEC	chr2	32463324	Missense_Mutation	novel	E1628D	0.28
UCEC	chr2	32481363	Silent	novel	D2484D	0.14
UCEC	chr2	32499797	Missense_Mutation	novel	K2907Q	0.14
UCEC	chr2	32500070	Missense_Mutation	novel	L2998M	0.38
UCEC	chr2	32508135	Missense_Mutation	rs372922939	R3286W	0.38
UCEC	chr2	32509845	Missense_Mutation	rs569695290	A3363V	0.15
UCEC	chr2	32515319	Missense_Mutation	novel	S3633Y	0.54
UCEC	chr2	32549380	Missense_Mutation	novel	T4348I	0.3
UCEC	chr2	32617749	Missense_Mutation	novel	E4807K	0.19
UCEC	chr2	32406538	Silent	novel	S486S	0.38
UCEC	chr2	32525598	Missense_Mutation	novel	V3964M	0.4
UCEC	chr2	32509807	Silent	novel	S3350S	0.39
UCEC	chr2	32415547	Silent	NA	C752C	0.28
UCEC	chr2	32441389	Missense_Mutation	rs763922153	R1291W	0.25
UCEC	chr2	32607550	Missense_Mutation	NA	Q4722H	0.3
UCEC	chr2	32435562	Missense_Mutation	novel	H1159R	0.37
UCEC	chr2	32442098	Missense_Mutation	novel	E1326D	0.63
UCEC	chr2	32468559	Missense_Mutation	novel	S1968N	0.42
UCEC	chr2	32485711	Silent	novel	L2589L	0.09
UCEC	chr2	32524956	Missense_Mutation	novel	E3898K	0.46
UCEC	chr2	32617725	Missense_Mutation	rs759980874	R4799C	0.34
UCEC	chr2	32415715	Missense_Mutation	rs745674124	Q808H	0.34
UCS	chr2	32543446	Missense_Mutation	rs748782106	R4166H	0.41
UCS	chr2	32415410	Missense_Mutation	novel	N707D	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2305	0.099937
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0924	0.2014
PRAD	DEL	0.065	0.096106
TGCT	AMP	0.24	0.0050216
THCA	DEL	0.022	0.1806

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00057	Kaplan-Meier Survival Analysis
READ	0.026	Kaplan-Meier Survival Analysis
UCEC	0.023	Kaplan-Meier Survival Analysis
LIHC	0.045	Kaplan-Meier Survival Analysis
UVM	0.024	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000115760 (Gene tree)
Gene ID: 57448
Gene Symbol: BIRC6
Alias: BRUCE
Full Name: baculoviral IAP repeat containing 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 261,872 bases
Position: chr2:32,357,028-32,618,899
Accession: 13516
RBP type: non-canonical RBP
Summary: This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461788	BIRC6-204	577	-	-	- (aa)	-	-
ENST00000466527	BIRC6-207	585	-	-	- (aa)	-	-
ENST00000497023	BIRC6-212	578	-	-	- (aa)	-	-
ENST00000462504	BIRC6-205	317	-	-	- (aa)	-	-
ENST00000431454	BIRC6-202	508	-	ENSP00000393590	110 (aa)	-	H7C094
ENST00000470250	BIRC6-208	472	-	-	- (aa)	-	-
ENST00000421745	BIRC6-201	15703	XM_005264449	ENSP00000393596	4857 (aa)	XP_005264506	Q9NR09
ENST00000648282	BIRC6-213	11526	XM_011533005	ENSP00000498175	3842 (aa)	XP_011531307	-
ENST00000483194	BIRC6-210	702	-	-	- (aa)	-	-
ENST00000465130	BIRC6-206	910	-	-	- (aa)	-	-
ENST00000496555	BIRC6-211	582	-	-	- (aa)	-	-
ENST00000471232	BIRC6-209	4226	-	-	- (aa)	-	-
ENST00000444173	BIRC6-203	575	-	ENSP00000413090	191 (aa)	-	H7C3P0

Gene Model

Click here to download ENSG00000115760's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa04215	Apoptosis - multiple species	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115760	Platelet Function Tests	6.5500000E-006	-
ENSG00000115760	Cholesterol	7.5110000E-006	-
ENSG00000115760	Cholesterol	1.9400000E-005	-
ENSG00000115760	Cholesterol	2.3820000E-005	-
ENSG00000115760	monocyte chemoattractant protein 1 (66-77)	2.0810000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115760	rs17428810	2	32510976	T	Cognitive performance	30038396	[0.012-0.024] unit increase	0.0179	EFO_0008354
ENSG00000115760	rs2710634	2	32583737	T	Educational attainment (MTAG)	30038396	[0.0047-0.0097] unit decrease	0.0072	EFO_0004784
ENSG00000115760	rs2599510	2	32600935	A	Self-reported math ability (MTAG)	30038396	[0.007-0.014] unit decrease	0.0105	EFO_0004875
ENSG00000115760	rs2710634	2	32583737	T	Highest math class taken (MTAG)	30038396	[0.0072-0.0138] unit decrease	0.0105	EFO_0004875
ENSG00000115760	rs17428810	2	32510976	T	Cognitive performance (MTAG)	30038396	[0.01-0.02] unit increase	0.0153	EFO_0008354
ENSG00000115760	rs2599510	2	32600935	G	Interleukin-18 levels	27989323	[0.11-0.2] SD units increase	0.1516	EFO_0004581
ENSG00000115760	rs176411	2	32418460	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000115760	rs2710634	2	32583737	C	Age of smoking initiation (MTAG)	30643251	[0.0071-0.0128] unit increase	0.00992778	EFO_0005670
ENSG00000115760	rs2754511	2	32545090	T	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0049-0.0105] unit decrease	0.00773373	EFO_0007878
ENSG00000115760	rs2754511	2	32545090	T	Smoking cessation (MTAG)	30643251	[0.006-0.0125] unit decrease	0.00925063	EFO_0004319
ENSG00000115760	rs176413	2	32421779	A	Risk-taking tendency (4-domain principal component model)	30643258	[0.01-0.021] unit increase	0.015470056	EFO_0008579
ENSG00000115760	rs2710606	2	32586842	A	General risk tolerance (MTAG)	30643258	[0.0044-0.0094] unit increase	0.0069	EFO_0008579
ENSG00000115760	rs2710634	2	32583737	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0075-0.0118] unit decrease	0.00966946	EFO_0006527
ENSG00000115760	rs2710634	2	32583737	C	Smoking initiation (ever regular vs never regular)	30643251	[0.013-0.023] unit decrease	0.017761428	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115760's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000922	spindle pole	18329369.	IDA	Component
GO:0004842	ubiquitin-protein transferase activity	15200957.	IDA	Function
GO:0004869	cysteine-type endopeptidase inhibitor activity	21873635.	IBA	Function
GO:0004869	cysteine-type endopeptidase inhibitor activity	15200957.	IMP	Function
GO:0005515	protein binding	14765125.15200957.18329369.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005768	endosome	18329369.	IDA	Component
GO:0005802	trans-Golgi network	18329369.	IDA	Component
GO:0005815	microtubule organizing center	18329369.	IDA	Component
GO:0006468	protein phosphorylation	18329369.	TAS	Process
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	-	IEA	Process
GO:0010951	negative regulation of endopeptidase activity	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016567	protein ubiquitination	18329369.	TAS	Process
GO:0030496	midbody	18329369.	IDA	Component
GO:0032465	regulation of cytokinesis	18329369.	IMP	Process
GO:0042127	regulation of cell proliferation	18414036.	TAS	Process
GO:0043066	negative regulation of apoptotic process	21873635.	IBA	Process
GO:0043066	negative regulation of apoptotic process	15200957.	IMP	Process
GO:0043066	negative regulation of apoptotic process	10544019.	TAS	Process
GO:0051301	cell division	-	IEA	Process
GO:0060711	labyrinthine layer development	-	IEA	Process
GO:0060712	spongiotrophoblast layer development	-	IEA	Process
GO:0061631	ubiquitin conjugating enzyme activity	21873635.	IBA	Function
GO:0090543	Flemming body	-	IEA	Component
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	14765125.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.