EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr268162313Missense_MutationnovelE164Q0.1
BRCAchr268174791Missense_MutationNAD250Y0.21
BRCAchr268161687Missense_MutationNAC121S0.55
CESCchr268161715SilentNAL130L0.27
CESCchr268162620Missense_MutationnovelT193S0.09
COADchr268161737Missense_Mutationrs755917828K138E0.36
COADchr268158505SilentnovelL111L0.07
COADchr268158527Missense_MutationnovelR119G0.3
COADchr268161766Missense_MutationnovelE147D0.07
GBMchr268161705Missense_MutationnovelV127D0.06
HNSCchr268162659Missense_MutationnovelD206N0.14
KIRCchr268173414Silentrs146981426L230L0.25
LGGchr2681748693'UTRnovel0.13
LGGchr2681748703'UTRnovel0.13
LIHCchr268162651Missense_MutationnovelV203A0.17
LIHCchr268158415SilentNAP81P0.25
LUADchr268161768Splice_SitenovelX147_splice0.49
LUADchr268162593Missense_Mutationrs745558390A184T0.15
LUADchr268173363Missense_MutationnovelG213S0.24
LUSCchr268158394SilentNAE74E0.12
LUSCchr268158087Missense_MutationnovelE51D0.31
PCPGchr268173386Frame_Shift_DelnovelA221Qfs*80.34
READchr268158482Missense_MutationNAG104R0.23
READchr268174794Nonsense_MutationnovelR251*0.08
SARCchr2681748413'UTRnovel0.45
SKCMchr268158400SilentnovelR76R0.17
STADchr268158407Missense_Mutationrs150153986P79A0.25
UCECchr268158521Nonsense_MutationNAE117*0.23
UCECchr268158423Missense_MutationNAR84I0.52
UCECchr2681749633'UTRnovel0.44
UCECchr268161682Splice_SitenovelX120_splice0.34
UCECchr268162639Missense_Mutationrs766561587R199Q0.31
UCECchr2681749523'UTRnovel0.15
UCECchr2681748493'UTRnovel0.19
UCECchr268158407Missense_MutationnovelP79T0.27
UCECchr268158501Missense_MutationnovelN110I0.17
UCECchr268158462Missense_MutationnovelT97N0.36
UCECchr2681748733'UTRnovel0.5
UCECchr268162269Missense_MutationNAA149V0.42
UCECchr268158491Missense_MutationnovelI107L0.23
UCECchr2681748213'UTRnovel0.37
UCECchr268162612Missense_MutationnovelT190N0.24
UCECchr268162593Missense_Mutationrs745558390A184T0.3
UCECchr268158432Missense_MutationnovelP87Q0.44

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.02430.08832
PAADDEL0.04890.2014
READDEL0.06670.19022

Survival Analysis
CancerP-value Q-value
MESO0.004

Kaplan-Meier Survival Analysis

ACC0.0025

Kaplan-Meier Survival Analysis

HNSC0.0012

Kaplan-Meier Survival Analysis

LUSC0.034

Kaplan-Meier Survival Analysis

BRCA0.0042

Kaplan-Meier Survival Analysis

ESCA0.024

Kaplan-Meier Survival Analysis

PAAD0.0056

Kaplan-Meier Survival Analysis

KICH0.023

Kaplan-Meier Survival Analysis

UCEC0.00018

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.011

Kaplan-Meier Survival Analysis

UVM0.044

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000115946 (Gene tree)
Gene ID
56902
Gene Symbol
PNO1
Alias
RRP20|KHRBP1
Full Name
partner of NOB1 homolog
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
18,395 bases
Position
chr2:68,157,844-68,176,238
Accession
32790
RBP type
non-canonical RBP
Summary
(Partner Of NOB1 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15497447Cloning and characterization of a novel human RNA binding protein gene PNO1.DNA Seq2004 JunZhou GJ-
21283762Protein-protein interactions within late pre-40S ribosomes.PLoS One2011 Jan 20Campbell MGdoi: 10.1371/journal.pone.0016194.
30862720EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway.Cancer Res2019 May 1Shen Adoi: 10.1158/0008-5472.CAN-18-3238
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000488728PNO1-203541--- (aa)--
ENST00000263657PNO1-2012286-ENSP00000263657252 (aa)-Q9NRX1
ENST00000430742PNO1-202616-ENSP00000405892136 (aa)-F8WBJ6
Gene Model
Click here to download ENSG00000115946's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000115946Electrocardiography1E-624324551
ENSG00000115946Trypanosoma cruzi1E-624324551
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000115946rs78556816268158894?PR interval in Tripanosoma cruzi seropositivity24324551EFO_0004462|EFO_0005530
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115946's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000115946PNO17265.934WBGene00013144Y53C12B.26665.934Caenorhabditis_elegans
ENSG00000115946PNO19892.742ENSMUSG00000020116Pno110092.742Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22681889.HDAFunction
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus15497447.IDAComponent
GO:0005829cytosol-TASComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us