EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29393359Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV.Int J Oncol2018 MarShen Ydoi: 10.3892/ijo.2018.4263
24344134PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.J Biol Chem2014 Feb 7Wang Wdoi: 10.1074/jbc.M113.508515
17671677Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis.Int J Oncol2007 SepKatayama A-
19287951BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers.Oncogene2007 Sep 6Yuli C-
25241153Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer.Arch Dermatol Res2014 NovOliveira Alves MGdoi: 10.1007/s00403-014-1500-8
17932034Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.J Biol Chem2007 Dec 28Bawa-Khalfe T-
23996296Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association.Med Oncol2013 DecMei Ddoi: 10.1007/s12032-013-0709-2
24819975Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor α.FEBS J2014 JulZhou Qdoi: 10.1111/febs.12840
20932933Small ubiquitin-related modifier-1: Wrestling with protein regulation.Int J Biochem Cell Biol2011 JanBarry Jdoi: 10.1016/j.biocel.2010.09.022
15123625Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification.J Biol Chem2004 Jul 9Ohshima T-
28222440SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells.Cell Physiol Biochem2017Jin Ldoi: 10.1159/000460836

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2202207177Intronnovel0.26
BLCAchr2202207263Nonsense_MutationnovelS99*0.2
BLCAchr2202238437Splice_Regionnovel0.43
BLCAchr2202210799Missense_MutationNAP58L0.58
BRCAchr2202214373Nonsense_MutationNAS50*0.27
BRCAchr2202220089SilentNAT10T0.32
CESCchr2202210755Missense_MutationnovelD73N0.1
CESCchr2202220071Missense_MutationNAK16N0.04
CESCchr2202214434Missense_MutationNAD30H0.13
CESCchr22022396285'Flanknovel0.25
CESCchr2202220093Nonsense_MutationNAS9*0.16
COADchr2202207280SilentnovelE93E0.07
COADchr2202207233Intronnovel0.37
COADchr2202207150Intronnovel0.22
ESCAchr22022067523'UTRnovel0.35
ESCAchr2202220076Frame_Shift_DelnovelD15Ifs*240.3
GBMchr2202220059Missense_MutationNAE20D0.16
KIRCchr2202207234Intronrs7600662470.11
LIHCchr22022385625'UTRnovel0.31
LUADchr2202207177Intronnovel0.08
LUADchr2202207317Frame_Shift_DelnovelG81Efs*70.12
LUADchr2202207185Intronnovel0.26
LUADchr2202207294Missense_MutationnovelE89Q0.12
LUADchr2202220100Missense_MutationnovelK7E0.27
LUSCchr2202207207Intronnovel0.38
LUSCchr2202220106Frame_Shift_DelnovelE5Rfs*340.5
LUSCchr2202210786SilentnovelL62L0.17
LUSCchr2202207232Intronnovel0.11
READchr2202214360SilentnovelR54R0.15
SKCMchr2202207274SilentnovelT95T0.26
SKCMchr2202210799Missense_MutationNAP58L0.31
STADchr2202210764Missense_MutationnovelR70G0.2
STADchr2202207233Intronnovel0.23
UCECchr2202207221Intronnovel0.22
UCECchr2202210792SilentnovelN60N0.22
UCECchr2202210806Missense_MutationNAG56S0.39
UCECchr2202207232Intronnovel0.5
UCECchr2202206962Intronnovel0.43
UCECchr22022066833'UTRnovel0.37
UCECchr2202214377Nonsense_MutationnovelE49*0.43
UCECchr2202207274SilentnovelT95T0.22
UCECchr22022385805'UTRnovel0.34
UCECchr2202220080Missense_MutationnovelL13F0.05
UCECchr2202210763Missense_MutationnovelR70I0.37
UCECchr2202207233Intronnovel0.5
UCECchr2202210752Missense_MutationnovelN74D0.19
UCECchr2202210737Nonsense_MutationNAE79*0.43
UCECchr2202206847Intronnovel0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PAADAMP0.07070.1091
PAADDEL0.02720.2014

Survival Analysis
CancerP-value Q-value
THYM0.011

Kaplan-Meier Survival Analysis

KIRC0.035

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

HNSC0.0048

Kaplan-Meier Survival Analysis

SKCM0.0083

Kaplan-Meier Survival Analysis

KIRP0.0037

Kaplan-Meier Survival Analysis

PAAD0.0053

Kaplan-Meier Survival Analysis

CESC0.027

Kaplan-Meier Survival Analysis

UCEC0.0042

Kaplan-Meier Survival Analysis

LIHC0.013

Kaplan-Meier Survival Analysis

CHOL0.048

Kaplan-Meier Survival Analysis

THCA0.038

Kaplan-Meier Survival Analysis

LUAD0.037

Kaplan-Meier Survival Analysis

OV0.0029

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000116030 (Gene tree)
Gene ID
7341
Gene Symbol
SUMO1
Alias
PIC1|GMP1|SMT3C|SUMO-1|SMT3H3|OFC10|UBL1
Full Name
small ubiquitin like modifier 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
32,429 bases
Position
chr2:202,206,180-202,238,608
Accession
12502
RBP type
non-canonical RBP
Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19946338Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity.Oncogene2010 Feb 18Oh SMdoi: 10.1038/onc.2009.411
17587596The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons.J Struct Biol2007 SepCasafont I-
25800734The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing.Nucleic Acids Res2015 Apr 20Liu HWdoi: 10.1093/nar/gkv246
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000409712SUMO1-209761-ENSP0000038629677 (aa)-B9A032
ENST00000469034SUMO1-210511--- (aa)--
ENST00000409627SUMO1-208722-ENSP0000038650073 (aa)-F8WBI1
ENST00000409498SUMO1-207779-ENSP0000038647262 (aa)-B8ZZ67
ENST00000409181SUMO1-204784-ENSP0000038675358 (aa)-B8ZZJ0
ENST00000392246SUMO1-2031536-ENSP00000376077101 (aa)-P63165
ENST00000392245SUMO1-2021071-ENSP00000376076101 (aa)-P63165
ENST00000392244SUMO1-201831-ENSP0000037607576 (aa)-P63165
ENST00000409205SUMO1-205534-ENSP0000038626762 (aa)-B8ZZ67
ENST00000409368SUMO1-2061187-ENSP00000387204146 (aa)-B8ZZN6
Gene Model
Click here to download ENSG00000116030's gene model file
Pathways
Pathway IDPathway NameSource
hsa03013RNA transportKEGG
hsa05418Fluid shear stress and atherosclerosisKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000116030rs67556902202225870?Heel bone mineral density30595370EFO_0009270
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116030's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000116030SUMO1100100.000ENSMUSG00000026021Sumo1100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-TASProcess
GO:0000792heterochromatin-IEAComponent
GO:0001222transcription corepressor binding17081986.IPIFunction
GO:0001650fibrillar center-IEAComponent
GO:0001741XY body-IEAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding9885291.11112409.11735126.11948183.12072434.14516784.15296745.15983381.16154161.16189514.16494873.16732283.17000644.17036045.17066076.17081985.17081986.17099698.17099700.17491593.17535915.17942705.17956732.18264111.18408014.18617892.19684601.19779455.20016594.20016603.20164921.20224576.20414307.20498050.20534433.20661221.20802522.21057547.21212807.21242980.21722636.21811235.21880768.21965678.21988832.22555612.22748127.22878415.23395904.24434214.24819975.25416956.25497731.25910212.26496610.26871637.29656893.IPIFunction
GO:0005634nucleus16791210.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus9412458.24651376.IDAComponent
GO:0005635nuclear envelope-TASComponent
GO:0005643nuclear pore9019411.TASComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane19223394.IDAComponent
GO:0006281DNA repair8812453.TASProcess
GO:0006303double-strand break repair via nonhomologous end joining-TASProcess
GO:0008022protein C-terminus binding15959518.IDAFunction
GO:0008022protein C-terminus binding17081986.IMPFunction
GO:0008076voltage-gated potassium channel complex19223394.IDAComponent
GO:0008134transcription factor binding-ISSFunction
GO:0015459potassium channel regulator activity19223394.IDAFunction
GO:0016032viral process-IEAProcess
GO:0016604nuclear body24651376.IDAComponent
GO:0016605PML body21873635.IBAComponent
GO:0016605PML body22406621.IDAComponent
GO:0016605PML body9412458.IDAComponent
GO:0016607nuclear speck-IEAComponent
GO:0016925protein sumoylation21873635.IBAProcess
GO:0016925protein sumoylation11889051.14752048.15572661.15637059.15959518.17696781.19223394.21965678.24651376.IDAProcess
GO:0016925protein sumoylation17081986.IMPProcess
GO:0016925protein sumoylation-TASProcess
GO:0019899enzyme binding11889051.15959518.IPIFunction
GO:0030425dendrite-IEAComponent
GO:0030578PML body organization-IEAProcess
GO:0030674protein binding, bridging17081986.IMPFunction
GO:0031334positive regulation of protein complex assembly18579533.IDAProcess
GO:0031386protein tag21873635.IBAFunction
GO:0031510SUMO activating enzyme complex15660128.IDAComponent
GO:0031625ubiquitin protein ligase binding18408734.IPIFunction
GO:0031965nuclear membrane-IDAComponent
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process18408734.IDAProcess
GO:0032880regulation of protein localization15637059.TASProcess
GO:0034605cellular response to heat11514557.IDAProcess
GO:0035259glucocorticoid receptor binding17081986.IPIFunction
GO:0043392negative regulation of DNA binding16626738.IDAProcess
GO:0043392negative regulation of DNA binding15637059.IMPProcess
GO:0043433negative regulation of DNA-binding transcription factor activity12072434.IMPProcess
GO:0044388small protein activating enzyme binding15660128.IPIFunction
GO:0044389ubiquitin-like protein ligase binding21873635.IBAFunction
GO:0045202synapse-IEAComponent
GO:0045759negative regulation of action potential19223394.IDAProcess
GO:0045892negative regulation of transcription, DNA-templated15572661.IDAProcess
GO:0045892negative regulation of transcription, DNA-templated12072434.IMPProcess
GO:0050821protein stabilization21968017.IDAProcess
GO:0060021roof of mouth development-ISSProcess
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TASProcess
GO:0071276cellular response to cadmium ion11514557.IDAProcess
GO:0086004regulation of cardiac muscle cell contraction-IEAProcess
GO:0090204protein localization to nuclear pore-IEAProcess
GO:0097165nuclear stress granule11514557.IDAComponent
GO:1901896positive regulation of calcium-transporting ATPase activity-IEAProcess
GO:1902260negative regulation of delayed rectifier potassium channel activity19223394.IDAProcess
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