EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23516550PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells.PLoS One2013Tsukahara Tdoi: 10.1371/journal.pone.0058749
17965020The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.J Biol Chem2008 Jan 4Buxad?? M-
29346433Vault RNAs partially induces drug resistance of human tumor cells MCF-7 by binding to the RNA/DNA-binding protein PSF and inducing oncogene GAGE6.PLoS One2018 Jan 18Chen Jdoi: 10.1371/journal.pone.0191325
19809274Melanotic Xp11 translocation renal cancer: a case with PSF-TFE3 gene fusion and up-regulation of melanogenetic transcripts.Am J Surg Pathol2009 DecChang IWdoi: 10.1097/PAS.0b013e3181ba7a5f.
24288667PSF knockdown enhances apoptosis via downregulation of LC3B in human colon cancer cells.Biomed Res Int2013Tsukahara Tdoi: 10.1155/2013/204973
25025966Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex.Br J Cancer2014 Aug 12Ji Qdoi: 10.1038/bjc.2014.383
27259250Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.Oncotarget2016 Jul 5Yang Pdoi: 10.18632/oncotarget.9741.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr135190502Nonsense_MutationNAQ471*0.29
BLCAchr135190502Nonsense_MutationNAQ471*0.1
BLCAchr135188001In_Frame_DelnovelR593_E595del0.08
BLCAchr1351843893'UTRnovel0.09
BLCAchr135191434SilentNAI308I0.48
BLCAchr135190502Nonsense_MutationNAQ471*0.52
BLCAchr135191434Missense_MutationnovelI308M0.11
BRCAchr1351930505'UTRnovel0.28
BRCAchr135188068Frame_Shift_DelnovelE575Gfs*90.39
BRCAchr135192966SilentNAL28L0.4
BRCAchr135188076Missense_MutationnovelR571Q0.15
BRCAchr135190862Missense_MutationNAN384S0.29RRM_1
BRCAchr1351842753'UTRnovel0.63
CESCchr1351841233'UTRnovel0.19
CESCchr135191338Splice_Regionnovel0.26
CESCchr135189363Missense_MutationNAR479C0.41
CESCchr135189057Missense_Mutationrs751612883R548H0.42
CESCchr1351837993'UTRnovel0.09
CESCchr1351837243'UTRrs5326672320.26
CESCchr135184491Missense_MutationnovelE697Q0.48
CESCchr135187072Missense_MutationnovelG639S0.61
COADchr135187047Missense_MutationNAG647D0.29
COADchr135187235Missense_MutationNAR611Q0.39
COADchr135188076Missense_MutationnovelR571Q0.28
COADchr135190515Missense_MutationnovelK466N0.05
COADchr135189192Missense_MutationNAR536C0.22
COADchr135184565Missense_Mutationrs371481157A672V0.42
COADchr1351842623'UTRnovel0.44
COADchr135189336Missense_MutationnovelY488H0.28
COADchr135189333Missense_MutationNAE489K0.25
COADchr135188047Missense_MutationnovelR581C0.25
COADchr1351844143'UTRnovel0.16
COADchr135189270Missense_MutationNAK510Q0.19
ESCAchr1351931095'UTRnovel0.38
ESCAchr135191498Missense_MutationnovelR287K0.2
GBMchr135189381Missense_MutationnovelE473K0.08
GBMchr135190949Frame_Shift_DelnovelT355Nfs*30.17
GBMchr1351931135'UTRnovel0.58
GBMchr135190965Frame_Shift_DelnovelA350Pfs*80.31
HNSCchr135188004Missense_MutationnovelE595G0.22
KIRCchr135190991Missense_MutationnovelS341Y0.21
KIRPchr135191491SilentnovelG289G0.4
KIRPchr135192863Missense_MutationNAP63T0.27
KIRPchr135191445Missense_MutationnovelP305S0.23
KIRPchr135184519SilentnovelT687T0.45
KIRPchr135190915SilentnovelF366F0.48
LGGchr135184463Missense_Mutationrs754019584R706Q0.3
LGGchr135189357Missense_MutationnovelA481T0.37
LIHCchr135188051Missense_MutationnovelM579I0.46
LIHCchr135189265Frame_Shift_InsnovelN511Kfs*120.41
LIHCchr135190751Missense_MutationNAK421T0.38RRM_1
LUADchr1351930715'UTRnovel0.14
LUADchr135187048Missense_MutationNAG647C0.37
LUADchr135187999Missense_MutationnovelY597H0.14
LUADchr135184473Missense_MutationnovelK703Q0.16
LUADchr135187066Missense_MutationnovelG641C0.17
LUADchr135187983Missense_MutationnovelY602F0.16
LUADchr135193043Missense_MutationnovelR3G0.23
LUADchr135187206Nonsense_MutationNAG621*0.06
LUSCchr135189258Missense_MutationnovelD514Y0.13
LUSCchr135191471Missense_MutationNAR296L0.06
LUSCchr135188059Missense_MutationnovelE577Q0.06
LUSCchr135190897SilentnovelA372A0.31
OVchr135190806Missense_MutationnovelI403L0.06RRM_1
OVchr135189198In_Frame_DelNAQ531_N533del0.45
OVchr135190840SilentnovelF391F0.1
READchr135190696Splice_RegionNAT439T0.19
READchr135187992Missense_Mutationrs765938341R599Q0.41
READchr135189258Missense_MutationnovelD514N0.37
READchr135191351Missense_MutationnovelF336C0.52
SARCchr135193045Missense_MutationnovelS2F0.06
SKCMchr135187031SilentNAT652T0.35
SKCMchr135188047Missense_MutationnovelR581C0.17
SKCMchr135190976Missense_MutationNAE346V0.73
SKCMchr135189192Missense_MutationNAR536C0.4
SKCMchr135190920Missense_MutationNAR365C0.68
SKCMchr135190860Missense_MutationnovelE385K0.43RRM_1
SKCMchr135192710Missense_MutationNAG114R0.4
STADchr135184516SilentNAP688P0.23
STADchr135184502Missense_MutationnovelR693I0.25
STADchr135188072SilentnovelR572R0.14
STADchr1351844453'UTRnovel0.05
STADchr135187236Nonsense_Mutationrs774720675R611*0.06
STADchr1351844133'UTRrs7586044680.16
STADchr135184565Missense_Mutationrs371481157A672V0.44
STADchr135191510Missense_MutationNAS283C0.25
STADchr135184565Missense_Mutationrs371481157A672V0.29
STADchr1351844133'UTRrs7586044680.48
STADchr135191504Frame_Shift_DelnovelL285Efs*220.18
STADchr135188016Missense_Mutationrs756075836R591H0.31
TGCTchr135190534Frame_Shift_DelnovelP460Lfs*530.12
THYMchr135191399Missense_MutationnovelY320C0.29
UCECchr1351843923'UTRnovel0.18
UCECchr135189247Silentrs779669519D517D0.37
UCECchr135191394Nonsense_MutationNAE322*0.29
UCECchr1351838923'UTRnovel0.18
UCECchr135187064SilentnovelG641G0.48
UCECchr135192738Missense_MutationnovelQ104H0.47
UCECchr1351838083'UTRnovel0.34
UCECchr1351842503'UTRnovel0.6
UCECchr135184511Missense_MutationnovelG690E0.5
UCECchr135190944Missense_MutationnovelM357V0.55
UCECchr1351836663'UTRnovel0.44
UCECchr135184516SilentNAP688P0.2
UCECchr135189017Missense_MutationNAK561N0.22
UCECchr135187225Silentrs189040885G614G0.25
UCECchr135190793Missense_MutationnovelR407H0.04RRM_1
UCECchr135192843Missense_MutationNAQ69H0.23
UCECchr1351841763'UTRnovel0.38
UCECchr1351843743'UTRnovel0.19
UCECchr135189075Missense_MutationnovelR542Q0.5
UCECchr1351842733'UTRnovel0.45
UCECchr135191527Splice_RegionnovelG277G0.24
UCECchr1351836623'UTRnovel0.56
UCECchr1351842733'UTRnovel0.17
UCECchr135191490Missense_MutationnovelE290K0.35
UCECchr135190773Frame_Shift_InsnovelG414Rfs*40.5RRM_1
UCECchr135187012Nonsense_MutationnovelG659*0.46
UCECchr1351838383'UTRnovel0.59
UCECchr1351844133'UTRrs7586044680.45
UCECchr1351931435'UTRnovel0.2
UCECchr1351837683'UTRnovel0.35
UCECchr1351843633'UTRnovel0.25
UCECchr135184583Missense_MutationnovelR666H0.2
UCECchr1351841523'UTRnovel0.3
UCECchr1351840793'UTRnovel0.23
UCECchr135190794Missense_MutationnovelR407S0.38RRM_1
UCECchr1351843033'UTRnovel0.25
UCECchr135190860Nonsense_MutationNAE385*0.22RRM_1
UCECchr1351840713'UTRnovel0.3
UCECchr135190779Missense_MutationnovelG412R0.25RRM_1
UCECchr135191519Missense_MutationnovelA280V0.08
UCECchr1351841543'UTRnovel0.5
UCECchr1351844133'UTRrs7586044680.35
UCECchr135190585Missense_MutationnovelR443P0.33
UCECchr135187224Missense_Mutationrs749368384G615R0.31
UCECchr135190788SilentnovelR409R0.05
UCECchr135192939SilentNAG37G0.5
UCECchr1351842733'UTRnovel0.33
UCECchr135188059Nonsense_MutationnovelE577*0.28
UCSchr135187060Missense_MutationnovelE643K0.16

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.08330.011841
TGCTDEL0.140.00046313

Survival Analysis
CancerP-value Q-value
THYM0.0021

Kaplan-Meier Survival Analysis

STAD0.018

Kaplan-Meier Survival Analysis

SARC0.00034

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

UCS0.044

Kaplan-Meier Survival Analysis

HNSC0.032

Kaplan-Meier Survival Analysis

PRAD0.0091

Kaplan-Meier Survival Analysis

BRCA0.0027

Kaplan-Meier Survival Analysis

TGCT0.045

Kaplan-Meier Survival Analysis

COAD0.0055

Kaplan-Meier Survival Analysis

PCPG0.017

Kaplan-Meier Survival Analysis

BLCA0.0038

Kaplan-Meier Survival Analysis

READ0.0084

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

OV0.039

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000116560 (Gene tree)
Gene ID
6421
Gene Symbol
SFPQ
Alias
PSF|PPP1R140
Full Name
splicing factor proline and glutamine rich
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
16,781 bases
Position
chr1:35,176,378-35,193,158
Accession
10774
RBP type
canonical RBP
Summary
(Splicing Factor Proline And Glutamine Rich) is a Protein Coding gene. Diseases associated with SFPQ include Renal Cell Carcinoma, Xp11-Associated and Adrenal Neuroblastoma. Among its related pathways are Signaling by GPCR and Signaling by PTK6. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PSPC1.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000349748RRM_1PF00076.221.3e-2912
ENSP00000349748RRM_1PF00076.221.3e-2922
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
8626664The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb.J Biol Chem1996 May 10Hallier M-
19650766Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions.Biochem J2009 Sep 25Hwang NRdoi: 10.1042/BJ20090854.
9756848The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.J Biol Chem1998 Oct 9Straub T-
12403470PSF and p54nrb bind a conserved stem in U5 snRNA.RNA2002 OctPeng R-
28810637Binding of LINE-1 RNA to PSF transcriptionally promotes GAGE6 and regulates cell proliferation and tumor formation in vitro.Exp Ther Med2017 AugLv Jdoi: 10.3892/etm.2017.4667
9605521Prolactin induces expression of FGF-2 and a novel FGF-responsive NonO/p54nrb-related mRNA in rat lymphoma cells.Mol Cell Endocrinol1998 FebToo CK-
16263701A novel subtractive antibody phage display method to discover disease markers.Mol Cell Proteomics2006 FebHof D-
23618401The non-coding RNA llme23 drives the malignant property of human melanoma cells.J Genet Genomics2013 Apr 20Wu CFdoi: 10.1016/j.jgg.2013.03.001
26951683EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression.Proc Natl Acad Sci U S A2016 Mar 22Lee Ndoi: 10.1073/pnas.1601773113
30725116IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.Cell Mol Life Sci2019 Mayde Silva HCdoi: 10.1007/s00018-019-03033-4
19855157Hacking RNA: Hakai promotes tumorigenesis by enhancing the RNA-binding function of PSF.Cell Cycle2009 Nov 15Figueroa A-
22001927PSF controls expression of histone variants and cellular viability in thymocytes.Biochem Biophys Res Commun2011 Nov 4Heyd Fdoi: 10.1016/j.bbrc.2011.09.149
27019013The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability.Nat Neurosci2016 MayCosker KEdoi: 10.1038/nn.4280
30824709SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability.Nat Commun2019 Mar 1Petti Edoi: 10.1038/s41467-019-08863-1.
12810069p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor.Biochem Biophys Res Commun2003 Jul 4Ishitani K-
10847580Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element.Mol Endocrinol2000 JunUrban RJ-
15590677Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor.J Biol Chem2005 Feb 18Bladen CL-
22941645PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks.Nucleic Acids Res2012 Nov 1Krietsch Jdoi: 10.1093/nar/gks798
29263895From a retrovirus infection of mice to a long noncoding RNA that induces proto-oncogene transcription and oncogenesis via an epigenetic transcription switch.Signal Transduct Target Ther2016 May 13Garen Adoi: 10.1038/sigtrans.2016.7
31204691A new crystal structure and small-angle X-ray scattering analysis of the homodimer of human SFPQ.Acta Crystallogr F Struct Biol Commun2019 Jun 1Hewage TWdoi: 10.1107/S2053230X19006599
8449401Cloning and characterization of PSF, a novel pre-mRNA splicing factor.Genes Dev1993 MarPatton JG-
12169434NH2 terminus of PTB-associated splicing factor binds to the porcine P450scc IGF-I response element.Am J Physiol Endocrinol Metab2002 SepUrban RJ-
16410615The hepatitis B virus PRE contains a splicing regulatory element.Nucleic Acids Res2006 Jan 12Heise T-
11525732The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.Cell2001 Aug 24Zhang Z-
11168378Identification of tyrosine-phosphorylated proteins associated with the nuclear envelope.Eur J Biochem2001 JanOtto H-
15984930Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors.Biochem J2005 Nov 1Iacobazzi V-
19535458Novel roles of hakai in cell proliferation and oncogenesis.Mol Biol Cell2009 AugFigueroa Adoi: 10.1091/mbc.E08-08-0845
19439179BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.Cell Signal2009 SepLukong KEdoi: 10.1016/j.cellsig.2009.04.008
17188683Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract.FEBS Lett2007 Jan 23Huang CJ-
22416763Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.J Proteome Res2012 May 4Seyfried NTdoi: 10.1021/pr2010814
23321469Proteomic analysis of interleukin enhancer binding factor 3 (Ilf3) and nuclear factor 90 (NF90) interactome.Biochimie2013 JunChaumet Adoi: 10.1016/j.biochi.2013.01.004
21933836The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.Hum Mol Genet2011 Dec 15Kunde SAdoi: 10.1093/hmg/ddr430
20554522Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U).J Biol Chem2010 Aug 20Kawano Sdoi: 10.1074/jbc.M110.112979
25436547Paraspeckles: possible nuclear hubs by the RNA for the RNA.Biomol Concepts2012 OctHirose Tdoi: 10.1515/bmc-2012-0017.
27491955Control of the heat stress-induced alternative splicing of a subset of genes by hnRNP K.Genes Cells2016 SepYamamoto Kdoi: 10.1111/gtc.12400
24413662p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly.Nucleic Acids Res2014 AprIzumi Hdoi: 10.1093/nar/gkt1365
26816005Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.PLoS One2016 Jan 27Ansseau Edoi: 10.1371/journal.pone.0146893
26261210TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells.Nucleic Acids Res2015 Oct 15Yarosh CAdoi: 10.1093/nar/gkv816
28846091NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.Nat Struct Mol Biol2017 OctJiang Ldoi: 10.1038/nsmb.3455
28893982Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF.Proc Natl Acad Sci U S A2017 Sep 26Takayama KIdoi: 10.1073/pnas.1706076114
29376859Dysregulation and Dislocation of SFPQ Disturbed DNA Organization in Alzheimer's Disease and Frontotemporal Dementia.J Alzheimers Dis2018Lu Jdoi: 10.3233/JAD-170659.
29719248Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain.Cell Rep2018 May 1Takeuchi Adoi: 10.1016/j.celrep.2018.03.141.
30026827MicroRNA-1296 Facilitates Proliferation, Migration And Invasion Of Colorectal Cancer Cells By Targeting SFPQ.J Cancer2018 Jun 6Tao Ydoi: 10.7150/jca.25427
30870781Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy.iScience2019 Mar 29Hosokawa Mdoi: 10.1016/j.isci.2019.02.023
30939845Splicing Factors Have an Essential Role in Prostate Cancer Progression and Androgen Receptor Signaling.Biomolecules2019 Apr 1Takayama KIdoi: 10.3390/biom9040131.
17967896Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.Mol Cell Biol2008 JanCobbold LC-
21881826PSF suppresses tau exon 10 inclusion by interacting with a stem-loop structure downstream of exon 10.J Mol Neurosci2011 NovRay Pdoi: 10.1007/s12031-011-9634-z
28341660The noncoding RNA linc-ADAMTS5 cooperates with RREB1 to protect from intervertebral disc degeneration through inhibiting ADAMTS5 expression.Clin Sci (Lond)2017 May 1Wang Kdoi: 10.1042/CS20160918
16938326Binding of the polypyrimidine tract-binding protein-associated splicing factor (PSF) to the hepatitis delta virus RNA.Virology2006 Dec 5-20Greco-Stewart VS-
19874820hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.Exp Cell Res2010 Feb 1Marko Mdoi: 10.1016/j.yexcr.2009.10.021
12358429Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD.RNA2002 SepEmili A-
10911990Myotonic dystrophy: the role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios.Mol Cell2000 JunTiscornia G-
10931916Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion.Nucleic Acids Res2000 Aug 15Akhmedov AT-
16767080Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.Nat Cell Biol2006 JulWu X-
25326457Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.Mol Cell Proteomics2015 JanSury MDdoi: 10.1074/mcp.M114.039370
27259250Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.Oncotarget2016 Jul 5Yang Pdoi: 10.18632/oncotarget.9741.
27158269Genomic analysis of mouse VL30 retrotransposons.Mob DNA2016 May 6Markopoulos Gdoi: 10.1186/s13100-016-0066-8
29346433Vault RNAs partially induces drug resistance of human tumor cells MCF-7 by binding to the RNA/DNA-binding protein PSF and inducing oncogene GAGE6.PLoS One2018 Jan 18Chen Jdoi: 10.1371/journal.pone.0191325
16339744Estrogen regulation of the rat anterior pituitary gland proteome.Exp Biol Med (Maywood)2005 DecBlake CA-
15790595The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.Hum Mol Genet2005 May 1Xu J-
15312650Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.Neuron2004 Aug 19Kanai Y-
19850496Analysis of arginine and lysine methylation utilizing peptide separations at neutral pH and electron transfer dissociation mass spectrometry.J Am Soc Mass Spectrom2010 JanSnijders APdoi: 10.1016/j.jasms.2009.09.010
19447914Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities.Nucleic Acids Res2009 JulMorozumi Ydoi: 10.1093/nar/gkp298
25025966Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex.Br J Cancer2014 Aug 12Ji Qdoi: 10.1038/bjc.2014.383
24327337The RNA/DNA-binding protein PSF relocates to cell membrane and contributes cells' sensitivity to antitumor drug, doxorubicin.Cytometry A2014 MarRen Sdoi: 10.1002/cyto.a.22423
30931476Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing.Nucleic Acids Res2019 Jun 4Mora Gallardo Cdoi: 10.1093/nar/gkz235.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000466745SFPQ-204662--- (aa)--
ENST00000357214SFPQ-2013747XM_005271112ENSP00000349748707 (aa)XP_005271169P23246
ENST00000460428SFPQ-202464-ENSP0000042507188 (aa)-H0Y9U2
ENST00000466213SFPQ-2031431--- (aa)--
ENST00000468598SFPQ-2052835--- (aa)--
ENST00000485365SFPQ-208693--- (aa)--
ENST00000485454SFPQ-209339--- (aa)--
ENST00000471991SFPQ-207440--- (aa)--
ENST00000490668SFPQ-210434--- (aa)--
ENST00000470472SFPQ-206874-ENSP00000424440223 (aa)-H0Y9K7
Gene Model
Click here to download ENSG00000116560's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000116560Glucose6.97285092837761E-1117903298
ENSG00000116560Glucose8.45202561052932E-1517903298
ENSG00000116560Glucose1.41968665486179E-1017903298
ENSG00000116560Glucose2.17672047814638E-917903298
ENSG00000116560Triglycerides6.07487614719653E-617903299
ENSG00000116560gamma-Glutamylcyclotransferase2.4649708664903E-517903293
ENSG00000116560Endometrial Neoplasms6E-621499250
ENSG00000116560Schizophrenia7E-626198764
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116560's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000116560SFPQ8563.776ENSG00000121390PSPC18074.528
ENSG00000116560SFPQ5371.429ENSG00000147140NONO9756.944
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000116560SFPQ9769.124ENSAPOG00000024257sfpq6274.376Acanthochromis_polyacanthus
ENSG00000116560SFPQ97100.000ENSAMEG00000000815SFPQ100100.000Ailuropoda_melanoleuca
ENSG00000116560SFPQ8870.707ENSACIG00000000905sfpq7270.481Amphilophus_citrinellus
ENSG00000116560SFPQ9769.124ENSAOCG00000002889sfpq6173.696Amphiprion_ocellaris
ENSG00000116560SFPQ9769.124ENSAPEG00000016556sfpq6173.696Amphiprion_percula
ENSG00000116560SFPQ9774.194ENSATEG00000002981sfpq6776.082Anabas_testudineus
ENSG00000116560SFPQ91100.000ENSANAG00000021268-10074.359Aotus_nancymaae
ENSG00000116560SFPQ9294.545ENSANAG00000027438-7796.296Aotus_nancymaae
ENSG00000116560SFPQ8689.474ENSANAG00000037798-9975.714Aotus_nancymaae
ENSG00000116560SFPQ8971.859ENSACLG00000022332sfpq6373.529Astatotilapia_calliptera
ENSG00000116560SFPQ8378.495ENSAMXG00000011538sfpq6572.273Astyanax_mexicanus
ENSG00000116560SFPQ100100.000ENSBTAG00000016328SFPQ10096.901Bos_taurus
ENSG00000116560SFPQ5041.964WBGene00017778nono-16748.207Caenorhabditis_elegans
ENSG00000116560SFPQ10099.011ENSCJAG00000001431SFPQ10099.011Callithrix_jacchus
ENSG00000116560SFPQ97100.000ENSCAFG00000003595-10091.796Canis_familiaris
ENSG00000116560SFPQ9793.519ENSCAFG00000018271-6692.971Canis_familiaris
ENSG00000116560SFPQ9794.907ENSCAFG00000017608-7188.199Canis_familiaris
ENSG00000116560SFPQ9785.185ENSCAFG00020010702-10090.883Canis_lupus_dingo
ENSG00000116560SFPQ9793.519ENSCAFG00020004881-6692.971Canis_lupus_dingo
ENSG00000116560SFPQ100100.000ENSCHIG00000023097SFPQ10096.218Capra_hircus
ENSG00000116560SFPQ97100.000ENSTSYG00000037120-100100.000Carlito_syrichta
ENSG00000116560SFPQ9786.175ENSTSYG00000035106-9885.673Carlito_syrichta
ENSG00000116560SFPQ91100.000ENSCPOG00000015018-10088.705Cavia_porcellus
ENSG00000116560SFPQ10099.293ENSCCAG00000029361-10099.293Cebus_capucinus
ENSG00000116560SFPQ91100.000ENSCATG00000032664-9681.487Cercocebus_atys
ENSG00000116560SFPQ9197.523ENSCATG00000036179-9597.523Cercocebus_atys
ENSG00000116560SFPQ97100.000ENSCLAG00000009583-100100.000Chinchilla_lanigera
ENSG00000116560SFPQ10099.718ENSCSAG00000001082SFPQ10099.718Chlorocebus_sabaeus
ENSG00000116560SFPQ89100.000ENSCHOG00000009131SFPQ10095.263Choloepus_hoffmanni
ENSG00000116560SFPQ9790.455ENSCPBG00000018674SFPQ6992.793Chrysemys_picta_bellii
ENSG00000116560SFPQ97100.000ENSCANG00000028087-100100.000Colobus_angolensis_palliatus
ENSG00000116560SFPQ9799.074ENSCGRG00001011698Sfpq6998.347Cricetulus_griseus_chok1gshd
ENSG00000116560SFPQ9799.074ENSCGRG00000010128Sfpq9599.536Cricetulus_griseus_crigri
ENSG00000116560SFPQ9770.968ENSCSEG00000007852sfpq6672.936Cynoglossus_semilaevis
ENSG00000116560SFPQ9768.203ENSCVAG00000019538sfpq6466.901Cyprinodon_variegatus
ENSG00000116560SFPQ10069.196ENSDARG00000011564sfpq10083.478Danio_rerio
ENSG00000116560SFPQ97100.000ENSDNOG00000049454SFPQ10096.910Dasypus_novemcinctus
ENSG00000116560SFPQ97100.000ENSDORG00000008109Sfpq10096.615Dipodomys_ordii
ENSG00000116560SFPQ9198.750ENSETEG00000001095SFPQ6792.807Echinops_telfairi
ENSG00000116560SFPQ100100.000ENSEASG00005012012SFPQ10097.055Equus_asinus_asinus
ENSG00000116560SFPQ100100.000ENSECAG00000000642SFPQ10097.055Equus_caballus
ENSG00000116560SFPQ9870.642ENSELUG00000023145sfpq6671.462Esox_lucius
ENSG00000116560SFPQ10097.878ENSFCAG00000042862SFPQ10097.878Felis_catus
ENSG00000116560SFPQ9793.056ENSFALG00000000731SFPQ10094.587Ficedula_albicollis
ENSG00000116560SFPQ9198.750ENSFDAG00000017723-10090.935Fukomys_damarensis
ENSG00000116560SFPQ9760.829ENSFHEG00000015200sfpq5668.966Fundulus_heteroclitus
ENSG00000116560SFPQ8874.747ENSGMOG00000011957sfpq6573.782Gadus_morhua
ENSG00000116560SFPQ8976.000ENSGMOG00000011950SFPQ8464.808Gadus_morhua
ENSG00000116560SFPQ9793.056ENSGALG00000002514SFPQ6894.292Gallus_gallus
ENSG00000116560SFPQ9863.927ENSGAFG00000014571sfpq5777.914Gambusia_affinis
ENSG00000116560SFPQ9771.759ENSGACG00000002034sfpq6874.654Gasterosteus_aculeatus
ENSG00000116560SFPQ97100.000ENSGGOG00000026354SFPQ100100.000Gorilla_gorilla
ENSG00000116560SFPQ8972.362ENSHBUG00000016818sfpq6373.529Haplochromis_burtoni
ENSG00000116560SFPQ9798.630ENSHGLG00000012001SFPQ7098.768Heterocephalus_glaber_female
ENSG00000116560SFPQ97100.000ENSHGLG00100004136-100100.000Heterocephalus_glaber_male
ENSG00000116560SFPQ8380.108ENSHCOG00000008612sfpq5872.912Hippocampus_comes
ENSG00000116560SFPQ8374.332ENSIPUG00000013076SFPQ7372.769Ictalurus_punctatus
ENSG00000116560SFPQ97100.000ENSSTOG00000014004-100100.000Ictidomys_tridecemlineatus
ENSG00000116560SFPQ9799.537ENSJJAG00000015633Sfpq6999.380Jaculus_jaculus
ENSG00000116560SFPQ9863.470ENSKMAG00000000238sfpq5470.805Kryptolebias_marmoratus
ENSG00000116560SFPQ8377.005ENSLBEG00000003163sfpq5773.206Labrus_bergylta
ENSG00000116560SFPQ9770.320ENSLACG00000014728SFPQ7080.093Latimeria_chalumnae
ENSG00000116560SFPQ8880.808ENSLOCG00000001067sfpq6881.654Lepisosteus_oculatus
ENSG00000116560SFPQ9799.537ENSLAFG00000015951SFPQ7594.835Loxodonta_africana
ENSG00000116560SFPQ10099.717ENSMFAG00000000797SFPQ10099.717Macaca_fascicularis
ENSG00000116560SFPQ10099.576ENSMMUG00000019154SFPQ10099.576Macaca_mulatta
ENSG00000116560SFPQ10099.859ENSMNEG00000038895SFPQ10099.859Macaca_nemestrina
ENSG00000116560SFPQ97100.000ENSMLEG00000010643-10096.866Mandrillus_leucophaeus
ENSG00000116560SFPQ9794.444ENSMLEG00000035352-9993.252Mandrillus_leucophaeus
ENSG00000116560SFPQ9774.654ENSMAMG00000007875sfpq6677.726Mastacembelus_armatus
ENSG00000116560SFPQ8971.859ENSMZEG00005026091sfpq6473.529Maylandia_zebra
ENSG00000116560SFPQ9792.627ENSMGAG00000004237SFPQ10091.049Meleagris_gallopavo
ENSG00000116560SFPQ9798.611ENSMAUG00000006402Sfpq6998.140Mesocricetus_auratus
ENSG00000116560SFPQ10098.303ENSMICG00000027265SFPQ10098.303Microcebus_murinus
ENSG00000116560SFPQ9798.611ENSMOCG00000019075Sfpq9995.021Microtus_ochrogaster
ENSG00000116560SFPQ9768.981ENSMMOG00000001074sfpq6574.419Mola_mola
ENSG00000116560SFPQ9793.981ENSMODG00000017937SFPQ6596.372Monodelphis_domestica
ENSG00000116560SFPQ9769.585ENSMALG00000010381sfpq6475.325Monopterus_albus
ENSG00000116560SFPQ9799.074MGP_CAROLIEiJ_G0026487Sfpq6998.347Mus_caroli
ENSG00000116560SFPQ9799.074ENSMUSG00000028820Sfpq6998.347Mus_musculus
ENSG00000116560SFPQ9799.074MGP_PahariEiJ_G0028818Sfpq6998.347Mus_pahari
ENSG00000116560SFPQ9799.074MGP_SPRETEiJ_G0027466Sfpq6998.347Mus_spretus
ENSG00000116560SFPQ97100.000ENSMPUG00000014931-9899.673Mustela_putorius_furo
ENSG00000116560SFPQ9799.074ENSMLUG00000027090SFPQ10097.111Myotis_lucifugus
ENSG00000116560SFPQ9799.537ENSNGAG00000000888Sfpq6998.763Nannospalax_galili
ENSG00000116560SFPQ8974.372ENSNBRG00000017479sfpq6473.756Neolamprologus_brichardi
ENSG00000116560SFPQ97100.000ENSNLEG00000035521-100100.000Nomascus_leucogenys
ENSG00000116560SFPQ9793.519ENSMEUG00000014082SFPQ6895.556Notamacropus_eugenii
ENSG00000116560SFPQ97100.000ENSOPRG00000013696SFPQ6699.772Ochotona_princeps
ENSG00000116560SFPQ9774.074ENSODEG00000005485SFPQ8687.021Octodon_degus
ENSG00000116560SFPQ8975.377ENSONIG00000017737sfpq6374.661Oreochromis_niloticus
ENSG00000116560SFPQ9796.759ENSOANG00000008789-10097.436Ornithorhynchus_anatinus
ENSG00000116560SFPQ97100.000ENSOCUG00000001877SFPQ86100.000Oryctolagus_cuniculus
ENSG00000116560SFPQ9768.664ENSORLG00000007459sfpq5772.158Oryzias_latipes
ENSG00000116560SFPQ9768.349ENSORLG00020011818sfpq5772.158Oryzias_latipes_hni
ENSG00000116560SFPQ10067.411ENSORLG00015002131sfpq5871.494Oryzias_latipes_hsok
ENSG00000116560SFPQ9799.537ENSOGAG00000027710SFPQ9998.857Otolemur_garnettii
ENSG00000116560SFPQ97100.000ENSOARG00000019439SFPQ7199.769Ovis_aries
ENSG00000116560SFPQ9799.539ENSPPRG00000015478-10099.716Panthera_pardus
ENSG00000116560SFPQ97100.000ENSPTIG00000007710-100100.000Panthera_tigris_altaica
ENSG00000116560SFPQ100100.000ENSPTRG00000000518SFPQ9695.588Pan_troglodytes
ENSG00000116560SFPQ97100.000ENSPANG00000005380SFPQ7499.798Papio_anubis
ENSG00000116560SFPQ8977.500ENSPKIG00000023035sfpq7379.263Paramormyrops_kingsleyae
ENSG00000116560SFPQ9791.667ENSPSIG00000011494SFPQ10094.664Pelodiscus_sinensis
ENSG00000116560SFPQ7177.215ENSPMGG00000023883sfpq5881.115Periophthalmus_magnuspinnatus
ENSG00000116560SFPQ9799.074ENSPEMG00000009794Sfpq9798.726Peromyscus_maniculatus_bairdii
ENSG00000116560SFPQ6872.848ENSPMAG00000005583sfpq6772.555Petromyzon_marinus
ENSG00000116560SFPQ10092.825ENSPCIG00000000923SFPQ7093.673Phascolarctos_cinereus
ENSG00000116560SFPQ9764.220ENSPFOG00000003127sfpq7168.591Poecilia_formosa
ENSG00000116560SFPQ100100.000ENSPPYG00000001560SFPQ100100.000Pongo_abelii
ENSG00000116560SFPQ9798.174ENSPCAG00000006164SFPQ7798.834Procavia_capensis
ENSG00000116560SFPQ10098.020ENSPCOG00000027127SFPQ10098.020Propithecus_coquereli
ENSG00000116560SFPQ9799.074ENSPVAG00000001865SFPQ6997.314Pteropus_vampyrus
ENSG00000116560SFPQ8971.859ENSPNYG00000007494sfpq6273.303Pundamilia_nyererei
ENSG00000116560SFPQ8376.596ENSPNAG00000002128sfpq7373.198Pygocentrus_nattereri
ENSG00000116560SFPQ9799.074ENSRNOG00000058461Sfpq7098.347Rattus_norvegicus
ENSG00000116560SFPQ97100.000ENSRBIG00000035286SFPQ100100.000Rhinopithecus_bieti
ENSG00000116560SFPQ97100.000ENSRROG00000040992SFPQ100100.000Rhinopithecus_roxellana
ENSG00000116560SFPQ9181.707ENSSBOG00000033925-9674.474Saimiri_boliviensis_boliviensis
ENSG00000116560SFPQ97100.000ENSSBOG00000024972-100100.000Saimiri_boliviensis_boliviensis
ENSG00000116560SFPQ9787.963ENSSHAG00000012312-10090.883Sarcophilus_harrisii
ENSG00000116560SFPQ9793.548ENSSHAG00000016107-9790.200Sarcophilus_harrisii
ENSG00000116560SFPQ9774.654ENSSFOG00015009289sfpq7978.005Scleropages_formosus
ENSG00000116560SFPQ9773.148ENSSMAG00000018201sfpq6673.756Scophthalmus_maximus
ENSG00000116560SFPQ9770.833ENSSDUG00000008402sfpq6578.291Seriola_dumerili
ENSG00000116560SFPQ9770.833ENSSLDG00000018917sfpq6578.291Seriola_lalandi_dorsalis
ENSG00000116560SFPQ97100.000ENSSARG00000006409SFPQ100100.000Sorex_araneus
ENSG00000116560SFPQ9770.507ENSSPAG00000016550sfpq6474.830Stegastes_partitus
ENSG00000116560SFPQ100100.000ENSSSCG00000035690SFPQ10097.454Sus_scrofa
ENSG00000116560SFPQ9793.056ENSTGUG00000001722SFPQ10094.896Taeniopygia_guttata
ENSG00000116560SFPQ9969.820ENSTRUG00000003783sfpq6276.092Takifugu_rubripes
ENSG00000116560SFPQ9773.272ENSTNIG00000011331sfpq7276.027Tetraodon_nigroviridis
ENSG00000116560SFPQ9792.130ENSTTRG00000013930SFPQ6894.421Tursiops_truncatus
ENSG00000116560SFPQ7785.294ENSUAMG00000026758SFPQ10097.742Ursus_americanus
ENSG00000116560SFPQ9795.370ENSUMAG00000008056-10097.151Ursus_maritimus
ENSG00000116560SFPQ9781.481ENSVPAG00000006960-6790.315Vicugna_pacos
ENSG00000116560SFPQ9287.379ENSVVUG00000000874-10088.889Vulpes_vulpes
ENSG00000116560SFPQ9784.259ENSXETG00000009682sfpq10085.139Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II16731528.IDAProcess
GO:0000122negative regulation of transcription by RNA polymerase II15790595.IGIProcess
GO:0000122negative regulation of transcription by RNA polymerase II22783022.IMPProcess
GO:0000380alternative mRNA splicing, via spliceosome21873635.IBAProcess
GO:0000380alternative mRNA splicing, via spliceosome19874820.IMPProcess
GO:0000724double-strand break repair via homologous recombination20813759.IMPProcess
GO:0000785chromatin16731528.IDAComponent
GO:0000976transcription regulatory region sequence-specific DNA binding21873635.IBAFunction
GO:0000976transcription regulatory region sequence-specific DNA binding-ISSFunction
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-ISSFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0002218activation of innate immune response28712728.IDAProcess
GO:0003677DNA binding25765647.IDAFunction
GO:0003682chromatin binding-ISSFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding9848648.10653975.11259580.11514619.15790595.16417406.16731528.18457437.19439179.19874820.20932480.21988832.23714182.25765647.30021884.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus15790595.IDAComponent
GO:0005654nucleoplasm19874820.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006397mRNA processing8449401.TASProcess
GO:0008380RNA splicing8449401.TASProcess
GO:0016363nuclear matrix19874820.IDAComponent
GO:0016607nuclear speck-IEAComponent
GO:0032839dendrite cytoplasm-IEAComponent
GO:0042382paraspeckles19874820.25765647.IDAComponent
GO:0042752regulation of circadian rhythm-ISSProcess
GO:0042754negative regulation of circadian rhythm-ISSProcess
GO:0042803protein homodimerization activity25765647.IPIFunction
GO:0042826histone deacetylase binding16731528.IPIFunction
GO:0044212transcription regulatory region DNA binding16731528.IDAFunction
GO:0045087innate immune response-IEAProcess
GO:0045876positive regulation of sister chromatid cohesion-IEAProcess
GO:0045892negative regulation of transcription, DNA-templated-ISSProcess
GO:0045944positive regulation of transcription by RNA polymerase II25765647.IMPProcess
GO:0048511rhythmic process-IEAProcess
GO:0070888E-box binding-ISSFunction
GO:0070932histone H3 deacetylation-ISSProcess
GO:0090575RNA polymerase II transcription factor complex-ISSComponent
GO:0098963dendritic transport of messenger ribonucleoprotein complex-IEAProcess
GO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway15790595.IDAProcess
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