EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29474458	Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.	PLoS One	2018 Feb 23	Arpalahti L	doi: 10.1371/journal.pone.0193125
28681694	UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.	Tumour Biol	2017 Jul	Arpalahti L	doi: 10.1177/1010428317716078.
25123264	High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.	Tumour Biol	2014 Nov	Wang L	doi: 10.1007/s13277-014-2446-3

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	193059961	5'Flank	novel		0.15
BLCA	chr1	193022958	Missense_Mutation	novel	E272K	0.48
BLCA	chr1	193051797	Nonsense_Mutation	NA	E33*	0.19
BLCA	chr1	193059231	Silent	NA	L10L	0.23
BLCA	chr1	193059513	5'Flank	novel		0.47
BLCA	chr1	193051802	Missense_Mutation	novel	Q31P	0.17
BRCA	chr1	193023853	Silent	rs769820397	Q241Q	0.05
BRCA	chr1	193029610	Silent	novel	L98L	0.19
BRCA	chr1	193029403	Missense_Mutation	NA	H140R	0.14
BRCA	chr1	193023018	Missense_Mutation	NA	Q252E	0.22
CESC	chr1	193059898	5'Flank	novel		0.14
CESC	chr1	193029577	Silent	novel	E109E	0.29
CESC	chr1	193020425	Intron	novel		0.24
CESC	chr1	193059992	5'Flank	novel		0.08
CESC	chr1	193059926	5'Flank	novel		0.18
CESC	chr1	193016253	3'UTR	novel		0.05
COAD	chr1	193016332	3'UTR	novel		0.05
COAD	chr1	193018643	Intron	novel		0.28
COAD	chr1	193049775	Nonsense_Mutation	NA	R73*	0.56
COAD	chr1	193059508	5'Flank	novel		0.32
COAD	chr1	193020418	Intron	novel		0.21
COAD	chr1	193059675	5'Flank	novel		0.07
COAD	chr1	193059321	5'UTR	rs768018038		0.33
COAD	chr1	193029393	Silent	rs375167412	F143F	0.28
COAD	chr1	193049774	Missense_Mutation	NA	R73Q	0.28
COAD	chr1	193029411	Frame_Shift_Ins	novel	*Q138Lfs16**	0.08
ESCA	chr1	193016324	3'UTR	novel		0.24
ESCA	chr1	193029650	Missense_Mutation	novel	N85S	0.3
GBM	chr1	193016372	Missense_Mutation	novel	K323N	0.35
HNSC	chr1	193059978	5'Flank	novel		0.21
HNSC	chr1	193059879	5'Flank	novel		0.44
HNSC	chr1	193059378	5'UTR	novel		0.13
HNSC	chr1	193029638	Missense_Mutation	novel	A89G	0.16
HNSC	chr1	193016248	3'UTR	rs184132625		0.14
HNSC	chr1	193059195	Missense_Mutation	novel	I22M	0.65
HNSC	chr1	193016367	Missense_Mutation	novel	A325G	0.11
LIHC	chr1	193023947	Splice_Site	NA	X210_splice	0.35
LUAD	chr1	193018768	Intron	novel		0.25
LUAD	chr1	193029535	Silent	NA	A123A	0.53
LUAD	chr1	193059477	5'UTR	novel		0.39
LUAD	chr1	193059961	5'Flank	novel		0.09
LUAD	chr1	193029387	Splice_Site	novel	X145_splice	0.1
LUAD	chr1	193029193	Missense_Mutation	novel	G184E	0.77
LUAD	chr1	193029579	Frame_Shift_Del	novel	*E109Rfs17**	0.21
LUAD	chr1	193059779	5'Flank	novel		0.4
LUAD	chr1	193023021	Missense_Mutation	NA	D251N	0.05
LUAD	chr1	193029239	Missense_Mutation	rs139595729	V169L	0.28
LUAD	chr1	193059407	5'UTR	novel		0.17
LUAD	chr1	193016368	Missense_Mutation	NA	A325S	0.23
LUSC	chr1	193059486	5'UTR	novel		0.24
LUSC	chr1	193059388	5'UTR	novel		0.23
LUSC	chr1	193059253	Missense_Mutation	NA	G3V	0.23
LUSC	chr1	193023884	Missense_Mutation	novel	Y231F	0.1
LUSC	chr1	193059472	5'UTR	novel		0.16
LUSC	chr1	193022928	Nonsense_Mutation	novel	K282*	0.15
LUSC	chr1	193049852	Splice_Site	NA	X47_splice	0.32
LUSC	chr1	193059419	5'UTR	novel		0.33
LUSC	chr1	193029386	Splice_Site	NA	X145_splice	0.2
LUSC	chr1	193023867	In_Frame_Del	novel	A236del	0.21
LUSC	chr1	193016288	3'UTR	novel		0.79
MESO	chr1	193049852	Splice_Site	NA	X47_splice	0.44
OV	chr1	193059453	5'UTR	novel		0.32
OV	chr1	193059270	5'UTR	novel		0.57
PAAD	chr1	193016148	3'UTR	novel		0.18
READ	chr1	193029393	Silent	rs375167412	F143F	0.25
READ	chr1	193015968	3'UTR	novel		0.8
READ	chr1	193016377	Missense_Mutation	rs146351256	A322T	0.21
READ	chr1	193059946	5'Flank	novel		0.5
SARC	chr1	193016124	3'UTR	novel		0.38
SKCM	chr1	193016283	3'UTR	novel		0.21
SKCM	chr1	193029277	Missense_Mutation	NA	S156L	0.26
SKCM	chr1	193049776	Silent	NA	S72S	0.15
SKCM	chr1	193016305	3'UTR	novel		0.69
STAD	chr1	193059919	5'Flank	novel		0.18
STAD	chr1	193049774	Missense_Mutation	NA	R73Q	0.1
UCEC	chr1	193016128	3'UTR	novel		0.15
UCEC	chr1	193028087	Missense_Mutation	novel	Q209H	0.21
UCEC	chr1	193059962	5'Flank	novel		0.3
UCEC	chr1	193029558	Nonsense_Mutation	NA	E116*	0.3
UCEC	chr1	193051811	Missense_Mutation	rs770894191	R28Q	0.3
UCEC	chr1	193049818	Nonsense_Mutation	NA	W58*	0.14
UCEC	chr1	193029285	Silent	novel	T153T	0.29
UCEC	chr1	193016020	3'UTR	novel		0.44
UCEC	chr1	193016210	3'UTR	novel		0.27
UCEC	chr1	193049764	Silent	rs200634415	T76T	0.28
UCEC	chr1	193059516	5'Flank	novel		0.23
UCEC	chr1	193059433	5'UTR	novel		0.25
UCEC	chr1	193023926	Missense_Mutation	novel	R217Q	0.1
UCEC	chr1	193016370	Missense_Mutation	novel	K324T	0.38
UCEC	chr1	193020336	Intron	novel		0.28
UCEC	chr1	193059507	5'Flank	novel		0.19
UCEC	chr1	193023876	Frame_Shift_Del	novel	*Q233Dfs20**	0.11
UCEC	chr1	193022992	Silent	NA	I260I	0.23
UCEC	chr1	193029413	Nonsense_Mutation	novel	R137*	0.24
UCEC	chr1	193028145	Missense_Mutation	novel	A190V	0.37
UCEC	chr1	193018571	Intron	novel		0.38
UCEC	chr1	193021114	Missense_Mutation	novel	I310L	0.24
UCEC	chr1	193059732	5'Flank	novel		0.36
UCEC	chr1	193029544	Silent	novel	S120S	0.4
UCEC	chr1	193059345	5'UTR	novel		0.27
UCEC	chr1	193059811	5'Flank	novel		0.2
UCEC	chr1	193059423	5'UTR	novel		0.09
UCEC	chr1	193016179	3'UTR	novel		0.31
UCEC	chr1	193059263	5'UTR	novel		0.38
UCEC	chr1	193049840	Missense_Mutation	novel	G51E	0.5
UCEC	chr1	193022960	Missense_Mutation	NA	I271T	0.33
UCEC	chr1	193022933	Missense_Mutation	NA	R280I	0.25
UCEC	chr1	193029197	Nonsense_Mutation	novel	E183*	0.09
UCEC	chr1	193022942	Missense_Mutation	novel	K277T	0.08
UCEC	chr1	193051771	Missense_Mutation	novel	E41D	0.16
UCEC	chr1	193018612	Intron	novel		0.25
UCEC	chr1	193059950	5'Flank	novel		0.22
UCEC	chr1	193059799	5'Flank	novel		0.26
UCEC	chr1	193059922	5'Flank	rs373291362		0.39
UCEC	chr1	193022971	Frame_Shift_Ins	novel	*N267Kfs6**	0.36
UCEC	chr1	193023922	Silent	NA	F218F	0.55
UCEC	chr1	193018605	Intron	novel		0.62
UCEC	chr1	193023905	Missense_Mutation	novel	V224A	0.27
UCEC	chr1	193021111	Missense_Mutation	novel	P311S	0.09
UCEC	chr1	193029285	Silent	novel	T153T	0.64
UCEC	chr1	193016248	3'UTR	rs184132625		0.39
UCEC	chr1	193059902	5'Flank	novel		0.38
UCS	chr1	193023926	Missense_Mutation	novel	R217Q	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0686	0.033566
DLBC	DEL	0.0417	0.0017831
KIRC	AMP	0.0852	0.059566
PAAD	AMP	0.2174	0.085665
READ	AMP	0.2606	0.14328
TGCT	AMP	0.34	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00079	Kaplan-Meier Survival Analysis
SARC	0.041	Kaplan-Meier Survival Analysis
ACC	0.00024	Kaplan-Meier Survival Analysis
SKCM	0.035	Kaplan-Meier Survival Analysis
KIRP	0.00022	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
CESC	0.0061	Kaplan-Meier Survival Analysis
LAML	0.021	Kaplan-Meier Survival Analysis
KICH	0.0062	Kaplan-Meier Survival Analysis
UCEC	0.0054	Kaplan-Meier Survival Analysis
LIHC	0.017	Kaplan-Meier Survival Analysis
LGG	0.003	Kaplan-Meier Survival Analysis
THCA	0.004	Kaplan-Meier Survival Analysis
LUAD	0.0013	Kaplan-Meier Survival Analysis
OV	0.0063	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

PRI

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116750 (Gene tree)
Gene ID: 51377
Gene Symbol: UCHL5
Alias: UCH37|CGI-70|INO80R
Full Name: ubiquitin C-terminal hydrolase L5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 47,858 bases
Position: chr1:193,012,250-193,060,107
Accession: 19678
RBP type: non-canonical RBP
Summary: (Ubiquitin C-Terminal Hydrolase L5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include endopeptidase inhibitor activity. An important paralog of this gene is BAP1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000443327	UCHL5-211	785	-	ENSP00000391153	183 (aa)	-	H0Y4E0
ENST00000367450	UCHL5-203	1355	XM_006711370	ENSP00000356420	368 (aa)	XP_006711433	Q5LJA9
ENST00000367451	UCHL5-204	1346	XM_017001439	ENSP00000356421	355 (aa)	XP_016856928	Q5LJA5
ENST00000449480	UCHL5-212	784	-	ENSP00000402847	115 (aa)	-	H0Y636
ENST00000483156	UCHL5-213	417	-	-	- (aa)	-	-
ENST00000367454	UCHL5-205	1815	-	ENSP00000356424	328 (aa)	-	Q9Y5K5
ENST00000367455	UCHL5-206	5327	XM_017001436	ENSP00000356425	329 (aa)	XP_016856925	Q9Y5K5
ENST00000367449	UCHL5-202	1507	XM_006711369	ENSP00000356419	316 (aa)	XP_006711432	Q9Y5K5
ENST00000367448	UCHL5-201	1534	XM_005245246	ENSP00000356418	326 (aa)	XP_005245303	Q9Y5K5
ENST00000421683	UCHL5-210	834	-	ENSP00000389563	258 (aa)	-	Q5LJB0
ENST00000417752	UCHL5-208	577	-	ENSP00000412265	165 (aa)	-	Q5LJB1
ENST00000416915	UCHL5-207	411	-	ENSP00000392416	99 (aa)	-	H0Y4K0
ENST00000420791	UCHL5-209	1329	XM_017001443	ENSP00000408720	218 (aa)	XP_016856932	H0Y6Y4

Gene Model

Click here to download ENSG00000116750's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116750	Marijuana Abuse	5E-6	21668797

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116750	rs9427573	1	193026083	?	Cannabis dependence	21668797	[1.71-3.82]	2.56	EFO_0007191
ENSG00000116750	rs10921304	1	193022653	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116750's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116750	UCHL5	99	46.965	WBGene00006724	ubh-4	92	47.284	Caenorhabditis_elegans
ENSG00000116750	UCHL5	100	61.830	FBgn0011327	Uch-L5	99	60.241	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	18922472.	IDA	Function
GO:0004866	endopeptidase inhibitor activity	18162577.	IMP	Function
GO:0005515	protein binding	11163772.16990800.17139257.18922472.19490896.19615732.21303910.21516116.25416956.	IPI	Function
GO:0005634	nucleus	18922472.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	18922472.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0010951	negative regulation of endopeptidase activity	-	IEA	Process
GO:0016579	protein deubiquitination	21873635.	IBA	Process
GO:0016579	protein deubiquitination	18922472.	IDA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0021670	lateral ventricle development	-	IEA	Process
GO:0030901	midbrain development	-	IEA	Process
GO:0031011	Ino80 complex	21303910.	IDA	Component
GO:0031011	Ino80 complex	18922472.	IDA	Component
GO:0031597	cytosolic proteasome complex	-	IEA	Component
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	23770237.	IMP	Process
GO:0048853	forebrain morphogenesis	-	IEA	Process
GO:0061136	regulation of proteasomal protein catabolic process	18162577.	IMP	Process
GO:0070628	proteasome binding	18162577.18922472.	IDA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

PRI

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.