EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23626713	The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.	PLoS One	2013 Apr 23	Hung PF	doi: 10.1371/journal.pone.0061664
22999822	Kinesin family member 14 is a candidate prognostic marker for outcome of glioma patients.	Cancer Epidemiol	2013 Feb	Wang Q	doi: 10.1016/j.canep.2012.08.011
15897902	KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers.	Oncogene	2005 Jul 14	Corson TW	-
17545527	KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.	Clin Cancer Res	2007 Jun 1	Corson TW	-
24784001	KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.	Neoplasia	2014 Mar	Singel SM	doi: 10.1016/j.neo.2014.03.008.
25528264	The role of KIF14 in patient-derived primary cultures of high-grade serous ovarian cancer cells.	J Ovarian Res	2014 Dec 21	Th??riault BL	doi: 10.1186/s13048-014-0123-1.
16570270	KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.	Int J Cancer	2006 Sep 1	Corson TW	-
24626475	Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer.	PLoS One	2014 Mar 13	Th??riault BL	doi: 10.1371/journal.pone.0091540
19509238	Consensus transcriptome signature of perineural invasion in pancreatic carcinoma.	Mol Cancer Ther	2009 Jun	Abiatari I	doi: 10.1158/1535-7163.MCT-08-0755
23479679	A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer.	Clin Cancer Res	2013 Apr 15	Singel SM	doi: 10.1158/1078-0432.CCR-13-0082
27128470	Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.	Biosci Rep	2016 Apr 5	Wang W	doi: 10.1042/BSR20150314
21618518	Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer.	Int J Cancer	2012 Apr 15	Th??riault BL	doi: 10.1002/ijc.26189
23414349	Suppression of KIF14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome.	Cancer Sci	2013 May	Yang T	doi: 10.1111/cas.12128
17099872	Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.	Genes Chromosomes Cancer	2007 Feb	Bowles E	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	200602026	Missense_Mutation	NA	M674I	0.17
BLCA	chr1	200565549	Missense_Mutation	novel	R1261T	0.28
BLCA	chr1	200618032	Missense_Mutation	NA	R231T	0.85
BLCA	chr1	200618562	Silent	novel	L54L	0.4
BLCA	chr1	200565445	Missense_Mutation	novel	L1296V	0.13
BLCA	chr1	200598348	Missense_Mutation	novel	S813F	0.31
BLCA	chr1	200559369	Missense_Mutation	novel	E1438D	0.44
BLCA	chr1	200580329	Silent	novel	L1130L	0.32
BLCA	chr1	200600409	Silent	NA	T749T	0.18
BLCA	chr1	200617841	Nonsense_Mutation	novel	Q295*	0.16
BLCA	chr1	200615482	Missense_Mutation	novel	H414Y	0.67
BLCA	chr1	200586161	Frame_Shift_Del	novel	*I1061Lfs28**	0.08
BLCA	chr1	200581264	Missense_Mutation	NA	S1091L	0.35
BLCA	chr1	200625047	5'Flank	novel		0.23
BLCA	chr1	200565556	Missense_Mutation	novel	E1259K	0.15
BLCA	chr1	200589282	Missense_Mutation	NA	H1017N	0.32
BLCA	chr1	200615397	Missense_Mutation	novel	C442F	0.13
BLCA	chr1	200617687	Missense_Mutation	novel	S346C	0.05
BLCA	chr1	200553747	Missense_Mutation	novel	L1530V	0.26
BLCA	chr1	200603282	Silent	NA	S641S	0.11
BRCA	chr1	200554579	Missense_Mutation	novel	E1486K	0.08
BRCA	chr1	200600070	Missense_Mutation	NA	Q782E	0.21
BRCA	chr1	200615583	Missense_Mutation	NA	V380A	0.17
BRCA	chr1	200569932	Silent	rs757462223	L1214L	0.1
BRCA	chr1	200602035	Frame_Shift_Ins	novel	*K671Nfs9**	0.13
BRCA	chr1	200602036	Frame_Shift_Ins	novel	*K671Tfs8**	0.13
BRCA	chr1	200602017	Silent	novel	T677T	0.03
BRCA	chr1	200559453	Splice_Site	novel	X1411_splice	0.1
BRCA	chr1	200554579	Missense_Mutation	novel	E1486K	0.09
BRCA	chr1	200617773	Silent	novel	P317P	0.04
BRCA	chr1	200618333	Missense_Mutation	NA	E131K	0.1
BRCA	chr1	200589315	Missense_Mutation	novel	H1006Y	0.07
BRCA	chr1	200560827	Silent	novel	I1375I	0.09
BRCA	chr1	200553423	Missense_Mutation	NA	E1638K	0.26
BRCA	chr1	200580260	Silent	novel	L1153L	0.15
BRCA	chr1	200617760	Missense_Mutation	NA	L322I	0.23
BRCA	chr1	200615373	Missense_Mutation	NA	G450V	0.34
BRCA	chr1	200617823	Missense_Mutation	NA	P301A	0.27
CESC	chr1	200592135	Missense_Mutation	novel	G920S	0.13
CESC	chr1	200615516	Silent	novel	I402I	0.14
CESC	chr1	200615517	Frame_Shift_Ins	novel	*I402Tfs27**	0.15
CESC	chr1	200618699	Frame_Shift_Ins	novel	*R9Ffs6**	0.14
CESC	chr1	200603890	Silent	novel	L604L	0.15
CESC	chr1	200553205	3'UTR	novel		0.38
CESC	chr1	200589324	Missense_Mutation	novel	K1003E	0.33
CESC	chr1	200592114	Missense_Mutation	novel	A927T	0.36
CESC	chr1	200618007	Silent	novel	P239P	0.29
CESC	chr1	200560730	Missense_Mutation	novel	S1408G	0.21
CESC	chr1	200601942	Silent	novel	V702V	0.24
CESC	chr1	200618634	Silent	novel	L30L	0.26
CESC	chr1	200553570	Missense_Mutation	NA	D1589H	0.22
CHOL	chr1	200618311	Missense_Mutation	novel	I138R	0.63
COAD	chr1	200554591	Nonsense_Mutation	NA	Q1482*	0.38
COAD	chr1	200569979	Missense_Mutation	NA	R1198I	0.25
COAD	chr1	200600103	Nonsense_Mutation	NA	E771*	0.42
COAD	chr1	200614367	Missense_Mutation	NA	R469I	0.3
COAD	chr1	200618275	Missense_Mutation	novel	E150G	0.12
COAD	chr1	200592166	Silent	novel	R909R	0.05
COAD	chr1	200605895	Splice_Site	novel	X536_splice	0.24
COAD	chr1	200618348	Missense_Mutation	rs780290398	K126E	0.39
COAD	chr1	200553349	3'UTR	novel		0.4
COAD	chr1	200565624	Missense_Mutation	novel	S1236F	0.22
COAD	chr1	200560766	Silent	novel	L1396L	0.4
COAD	chr1	200601912	Silent	rs145353826	N712N	0.46
COAD	chr1	200553261	3'UTR	novel		0.23
COAD	chr1	200618535	Missense_Mutation	NA	I63M	0.19
COAD	chr1	200560794	Silent	novel	G1386G	0.06
COAD	chr1	200560836	Missense_Mutation	rs753019306	K1372N	0.22
COAD	chr1	200592203	Missense_Mutation	NA	R897I	0.29
COAD	chr1	200593759	Missense_Mutation	NA	N854H	0.1
COAD	chr1	200603909	Missense_Mutation	rs373895990	R598Q	0.32
COAD	chr1	200608907	Missense_Mutation	rs771409397	S493G	0.34
ESCA	chr1	200555387	Missense_Mutation	novel	S1474L	0.27
ESCA	chr1	200617715	Missense_Mutation	rs147387069	E337K	0.25
GBM	chr1	200553349	3'UTR	novel		0.19
GBM	chr1	200592216	Missense_Mutation	novel	D893Y	0.18
GBM	chr1	200617693	Missense_Mutation	novel	N344T	0.21
GBM	chr1	200615539	Missense_Mutation	novel	T395S	0.04
GBM	chr1	200553492	Missense_Mutation	rs146186348	G1615S	0.42
GBM	chr1	200615593	Missense_Mutation	novel	A377S	0.09
GBM	chr1	200617809	Missense_Mutation	novel	K305N	0.5
GBM	chr1	200617951	Missense_Mutation	novel	S258I	0.05
GBM	chr1	200593671	Missense_Mutation	rs759631922	R883H	0.27
HNSC	chr1	200555445	Missense_Mutation	NA	E1455Q	0.17
HNSC	chr1	200553742	Silent	novel	L1531L	0.24
HNSC	chr1	200581253	Nonsense_Mutation	NA	Q1095*	0.1
HNSC	chr1	200581248	Silent	novel	E1096E	0.2
HNSC	chr1	200569990	Missense_Mutation	NA	M1194I	0.25
HNSC	chr1	200580298	Missense_Mutation	novel	E1141Q	0.3
HNSC	chr1	200618297	Missense_Mutation	novel	M143V	0.07
HNSC	chr1	200553617	Missense_Mutation	novel	S1573C	0.14
HNSC	chr1	200565559	Missense_Mutation	novel	D1258H	0.05
HNSC	chr1	200586217	Missense_Mutation	novel	D1042G	0.41
HNSC	chr1	200560733	Missense_Mutation	novel	A1407S	0.11
KIRC	chr1	200617957	Missense_Mutation	NA	H256R	0.2
KIRC	chr1	200586206	Missense_Mutation	NA	R1046G	0.25
KIRC	chr1	200618525	Missense_Mutation	NA	Y67N	0.27
KIRC	chr1	200617780	Missense_Mutation	NA	Q315L	0.4
KIRC	chr1	200618194	Missense_Mutation	NA	S177C	0.24
KIRC	chr1	200590240	Nonsense_Mutation	novel	K949delinsIGTSTL	0.04
KIRC	chr1	200593723	Missense_Mutation	NA	E866K	0.19
KIRP	chr1	200617903	Missense_Mutation	novel	E274G	0.33
LAML	chr1	200602065	Silent	novel	L661L	0.07
LAML	chr1	200590249	Missense_Mutation	novel	A946D	0.07
LAML	chr1	200602032	Silent	novel	T672T	0.14
LIHC	chr1	200553764	Missense_Mutation	novel	C1524S	0.04
LIHC	chr1	200553635	Frame_Shift_Del	novel	*V1567Pfs9**	0.64
LIHC	chr1	200581212	Silent	novel	Y1108Y	0.18
LIHC	chr1	200618003	Frame_Shift_Del	novel	*Q241Rfs33**	0.4
LIHC	chr1	200553563	Missense_Mutation	novel	L1591S	0.68
LIHC	chr1	200589265	Missense_Mutation	novel	I1022M	0.59
LIHC	chr1	200593756	Missense_Mutation	NA	F855V	0.19
LIHC	chr1	200617736	Missense_Mutation	rs116130210	A330T	0.12
LIHC	chr1	200589229	Silent	novel	L1034L	0.07
LUAD	chr1	200618309	Missense_Mutation	NA	D139Y	0.35
LUAD	chr1	200565449	Silent	NA	D1294D	0.78
LUAD	chr1	200565188	Missense_Mutation	NA	V1318I	0.31
LUAD	chr1	200618425	Missense_Mutation	novel	S100L	0.2
LUAD	chr1	200618230	Missense_Mutation	novel	R165M	0.38
LUAD	chr1	200598325	Missense_Mutation	novel	K821E	0.35
LUAD	chr1	200605292	Silent	NA	T579T	0.15
LUAD	chr1	200560725	Silent	novel	V1409V	0.27
LUAD	chr1	200589274	Missense_Mutation	novel	E1019D	0.37
LUAD	chr1	200553629	Missense_Mutation	NA	Q1569L	0.47
LUAD	chr1	200569990	Missense_Mutation	NA	M1194I	0.29
LUAD	chr1	200598402	Missense_Mutation	NA	Q795L	0.51
LUAD	chr1	200553658	Silent	rs768837535	Y1559Y	0.26
LUAD	chr1	200589261	Missense_Mutation	novel	V1024F	0.11
LUAD	chr1	200598356	Silent	novel	P810P	0.08
LUAD	chr1	200590193	Missense_Mutation	novel	A965S	0.17
LUAD	chr1	200590273	Splice_Site	NA	X938_splice	0.08
LUSC	chr1	200618263	Missense_Mutation	NA	N154S	0.45
LUSC	chr1	200598266	Missense_Mutation	novel	L840F	0.32
LUSC	chr1	200598260	Silent	NA	G842G	0.31
LUSC	chr1	200592230	Missense_Mutation	novel	V888A	0.17
LUSC	chr1	200553467	Missense_Mutation	novel	K1623T	0.28
LUSC	chr1	200555398	Missense_Mutation	rs547122818	I1470M	0.23
LUSC	chr1	200602068	Missense_Mutation	novel	W660C	0.15
LUSC	chr1	200598415	Nonsense_Mutation	novel	G791*	0.41
LUSC	chr1	200553380	3'UTR	novel		0.71
LUSC	chr1	200600437	Missense_Mutation	NA	R740Q	0.42
LUSC	chr1	200605367	Missense_Mutation	novel	K554N	0.36
LUSC	chr1	200569913	Missense_Mutation	NA	S1220L	0.35
LUSC	chr1	200581213	Missense_Mutation	NA	Y1108C	0.69
LUSC	chr1	200602050	Silent	novel	L666L	0.16
LUSC	chr1	200560794	Silent	novel	G1386G	0.45
LUSC	chr1	200617692	Silent	novel	N344N	0.09
LUSC	chr1	200580317	Missense_Mutation	novel	I1134M	0.14
LUSC	chr1	200581236	Missense_Mutation	novel	I1100M	0.07
LUSC	chr1	200618552	Missense_Mutation	novel	G58C	0.06
MESO	chr1	200581215	Nonsense_Mutation	novel	Y1107*	0.11
OV	chr1	200565461	Silent	novel	E1290E	0.05
OV	chr1	200586135	Silent	novel	Q1069Q	0.38
OV	chr1	200560811	Missense_Mutation	novel	A1381P	0.14
OV	chr1	200600087	Missense_Mutation	novel	A776D	0.4
OV	chr1	200554552	Missense_Mutation	novel	R1495G	0.07
OV	chr1	200617773	Silent	novel	P317P	0.04
OV	chr1	200624966	5'Flank	novel		0.34
OV	chr1	200565529	Frame_Shift_Del	novel	L1267*	0.14
OV	chr1	200553681	Missense_Mutation	NA	P1552S	0.36
PAAD	chr1	200555455	Splice_Site	novel	X1452_splice	0.24
PRAD	chr1	200618614	Missense_Mutation	NA	K37T	0.24
PRAD	chr1	200617995	Silent	novel	K243K	0.05
READ	chr1	200554502	Silent	NA	E1511E	0.28
READ	chr1	200589218	Frame_Shift_Del	novel	*Q1038Rfs3**	0.05
READ	chr1	200614377	Missense_Mutation	NA	I466L	0.19
READ	chr1	200618015	Missense_Mutation	novel	T237A	0.05
READ	chr1	200555445	Nonsense_Mutation	novel	E1455*	0.28
READ	chr1	200565573	Missense_Mutation	novel	F1253C	0.32
READ	chr1	200603909	Missense_Mutation	rs373895990	R598Q	0.35
READ	chr1	200605360	Missense_Mutation	rs371145728	A557T	0.34
READ	chr1	200608881	Missense_Mutation	novel	K501N	0.41
READ	chr1	200560827	Silent	NA	I1375I	0.32
READ	chr1	200565100	Missense_Mutation	novel	K1347T	0.23
READ	chr1	200608881	Missense_Mutation	novel	K501N	0.07
READ	chr1	200617771	Missense_Mutation	novel	K318T	0.42
SARC	chr1	200603846	Missense_Mutation	novel	R619Q	0.41
SKCM	chr1	200586222	Silent	NA	L1040L	0.21
SKCM	chr1	200603250	Missense_Mutation	NA	P652L	0.31
SKCM	chr1	200590123	Splice_Site	NA	X987_splice	0.18
SKCM	chr1	200615589	Missense_Mutation	NA	S378F	0.12
SKCM	chr1	200554545	Missense_Mutation	NA	V1497A	0.19
SKCM	chr1	200617738	Missense_Mutation	NA	S329F	0.28
SKCM	chr1	200575685	Missense_Mutation	NA	G1158S	0.23
SKCM	chr1	200553605	Missense_Mutation	NA	S1577F	0.29
SKCM	chr1	200565585	Missense_Mutation	rs763960016	S1249L	0.33
SKCM	chr1	200553491	Missense_Mutation	rs542837815	G1615D	0.66
SKCM	chr1	200618110	Missense_Mutation	NA	R205K	0.78
SKCM	chr1	200618369	Missense_Mutation	NA	L119F	0.2
SKCM	chr1	200605867	Silent	novel	I545I	0.46
SKCM	chr1	200598281	Silent	novel	S835S	0.46
SKCM	chr1	200559408	Missense_Mutation	NA	M1425I	0.37
SKCM	chr1	200553651	Missense_Mutation	novel	R1562G	0.42
SKCM	chr1	200554543	Missense_Mutation	NA	N1498Y	0.38
SKCM	chr1	200565446	Splice_Region	NA	N1295N	0.26
SKCM	chr1	200554570	Missense_Mutation	NA	E1489K	0.2
SKCM	chr1	200586117	Silent	novel	R1075R	0.31
SKCM	chr1	200601954	Silent	rs746449492	A698A	0.21
SKCM	chr1	200553342	3'UTR	novel		0.22
SKCM	chr1	200554540	Missense_Mutation	rs769821801	R1499C	0.13
SKCM	chr1	200618698	Missense_Mutation	novel	R9K	0.6
SKCM	chr1	200603228	Splice_Region	rs745318634	T659T	0.43
SKCM	chr1	200592234	Nonsense_Mutation	rs757053461	R887*	0.21
SKCM	chr1	200618479	Missense_Mutation	NA	P82L	0.16
SKCM	chr1	200589238	Missense_Mutation	novel	M1031I	0.26
SKCM	chr1	200618569	Missense_Mutation	rs201770638	P52L	0.19
STAD	chr1	200553300	3'UTR	novel		0.16
STAD	chr1	200618489	Missense_Mutation	novel	P79S	0.04
STAD	chr1	200553408	Missense_Mutation	NA	S1643G	0.25
STAD	chr1	200605335	Missense_Mutation	NA	D565V	0.2
STAD	chr1	200555447	Missense_Mutation	NA	K1454R	0.26
STAD	chr1	200560813	Missense_Mutation	novel	Q1380R	0.04
STAD	chr1	200603909	Missense_Mutation	rs373895990	R598Q	0.2
STAD	chr1	200618323	Missense_Mutation	NA	K134R	0.09
STAD	chr1	200590181	Missense_Mutation	NA	L969I	0.43
STAD	chr1	200603937	Missense_Mutation	novel	E589K	0.33
STAD	chr1	200565572	Frame_Shift_Del	NA	*F1253Lfs11**	0.15
STAD	chr1	200589239	Missense_Mutation	rs377490365	M1031T	0.08
STAD	chr1	200598361	Missense_Mutation	NA	D809N	0.47
STAD	chr1	200601956	Missense_Mutation	rs371788866	A698T	0.12
STAD	chr1	200553439	Silent	rs754764767	S1632S	0.24
STAD	chr1	200615548	Missense_Mutation	NA	H392D	0.45
STAD	chr1	200592168	Frame_Shift_Del	novel	*R909Gfs9**	0.31
STAD	chr1	200603245	Missense_Mutation	novel	R654C	0.17
STAD	chr1	200592095	Missense_Mutation	rs568570558	M933T	0.12
STAD	chr1	200600426	Missense_Mutation	NA	C744R	0.44
STAD	chr1	200570004	Missense_Mutation	NA	S1190C	0.36
TGCT	chr1	200560737	Silent	novel	K1405K	0.35
THCA	chr1	200569991	Missense_Mutation	NA	M1194K	0.33
THYM	chr1	200553529	Silent	novel	K1602K	0.1
UCEC	chr1	200554561	Missense_Mutation	NA	D1492Y	0.16
UCEC	chr1	200614317	Splice_Site	NA	X485_splice	0.36
UCEC	chr1	200592177	Missense_Mutation	NA	K906Q	0.32
UCEC	chr1	200565125	Missense_Mutation	novel	D1339Y	0.46
UCEC	chr1	200592233	Missense_Mutation	novel	R887Q	0.29
UCEC	chr1	200598406	Missense_Mutation	novel	F794L	0.53
UCEC	chr1	200553414	Missense_Mutation	novel	T1641A	0.49
UCEC	chr1	200618399	Missense_Mutation	novel	D109N	0.42
UCEC	chr1	200615538	Missense_Mutation	rs138621008	T395M	0.29
UCEC	chr1	200603934	Missense_Mutation	NA	E590K	0.15
UCEC	chr1	200600107	Missense_Mutation	novel	W769C	0.41
UCEC	chr1	200615537	Silent	rs749140614	T395T	0.32
UCEC	chr1	200618221	Missense_Mutation	novel	N168S	0.46
UCEC	chr1	200565228	Missense_Mutation	novel	Q1304H	0.33
UCEC	chr1	200618754	5'UTR	novel		0.4
UCEC	chr1	200586205	Missense_Mutation	rs570902338	R1046H	0.53
UCEC	chr1	200560836	Missense_Mutation	rs753019306	K1372N	0.22
UCEC	chr1	200589228	Missense_Mutation	NA	A1035T	0.21
UCEC	chr1	200618530	Missense_Mutation	NA	R65I	0.23
UCEC	chr1	200624919	5'Flank	NA		0.13
UCEC	chr1	200581270	Missense_Mutation	NA	K1089R	0.42
UCEC	chr1	200586127	Missense_Mutation	rs375038287	R1072Q	0.23
UCEC	chr1	200618620	Missense_Mutation	rs768534308	R35Q	0.3
UCEC	chr1	200565220	Missense_Mutation	novel	T1307I	0.12
UCEC	chr1	200624898	5'Flank	novel		0.17
UCEC	chr1	200603909	Missense_Mutation	rs373895990	R598Q	0.58
UCEC	chr1	200617945	Missense_Mutation	NA	G260E	0.26
UCEC	chr1	200617881	Silent	novel	C281C	0.06
UCEC	chr1	200555445	Nonsense_Mutation	novel	E1455*	0.34
UCEC	chr1	200590199	Nonsense_Mutation	novel	E963*	0.09
UCEC	chr1	200593761	Missense_Mutation	novel	K853T	0.26
UCEC	chr1	200617873	Missense_Mutation	novel	E284G	0.26
UCEC	chr1	200618530	Missense_Mutation	NA	R65I	0.42
UCEC	chr1	200554573	Missense_Mutation	novel	F1488V	0.34
UCEC	chr1	200560854	Missense_Mutation	novel	M1366I	0.32
UCEC	chr1	200600491	Missense_Mutation	novel	E722A	0.29
UCEC	chr1	200603322	Missense_Mutation	novel	K628R	0.42
UCEC	chr1	200602000	Missense_Mutation	novel	S683N	0.13
UCEC	chr1	200553272	3'UTR	novel		0.34
UCEC	chr1	200593671	Missense_Mutation	rs759631922	R883H	0.34
UCEC	chr1	200618599	Missense_Mutation	rs372557019	S42L	0.31
UCEC	chr1	200618141	Missense_Mutation	NA	K195Q	0.32
UCEC	chr1	200618530	Missense_Mutation	NA	R65I	0.35
UCEC	chr1	200590166	Frame_Shift_Ins	novel	*A974Sfs4**	0.27
UCEC	chr1	200559371	Missense_Mutation	novel	E1438K	0.42
UCEC	chr1	200589249	Nonsense_Mutation	rs372514522	R1028*	0.41
UCEC	chr1	200617999	Missense_Mutation	novel	S242N	0.4
UCEC	chr1	200553460	Silent	novel	V1625V	0.45
UCEC	chr1	200554531	Nonsense_Mutation	novel	E1502*	0.44
UCEC	chr1	200615542	Missense_Mutation	novel	D394Y	0.27
UCEC	chr1	200598422	Splice_Site	novel	X789_splice	0.15
UCEC	chr1	200617930	Missense_Mutation	novel	K265R	0.26
UCEC	chr1	200618192	Missense_Mutation	novel	S178A	0.33
UCEC	chr1	200600061	Missense_Mutation	NA	K785Q	0.42
UCEC	chr1	200600431	Missense_Mutation	NA	R742K	0.4
UCEC	chr1	200624914	5'Flank	rs544875711		0.43
UCEC	chr1	200618013	Silent	rs772474712	T237T	0.19
UCEC	chr1	200598422	Splice_Site	novel	X789_splice	0.26
UCEC	chr1	200581271	Missense_Mutation	novel	K1089Q	0.37
UCEC	chr1	200615507	Silent	novel	V405V	0.19
UCEC	chr1	200598244	Frame_Shift_Del	novel	*D848Ifs12**	0.49
UCEC	chr1	200553719	Missense_Mutation	rs780969944	R1539H	0.3
UCEC	chr1	200565522	Missense_Mutation	novel	S1270N	0.34
UCEC	chr1	200590239	Silent	novel	K949K	0.33
UCEC	chr1	200598396	Missense_Mutation	novel	D797G	0.23
UCEC	chr1	200603909	Missense_Mutation	rs373895990	R598Q	0.33
UCEC	chr1	200603909	Missense_Mutation	rs373895990	R598Q	0.34
UCEC	chr1	200559410	Missense_Mutation	novel	M1425L	0.35
UCEC	chr1	200608847	Missense_Mutation	novel	G513W	0.38
UCEC	chr1	200614386	Nonsense_Mutation	novel	E463*	0.55
UCEC	chr1	200617735	Missense_Mutation	novel	A330E	0.06
UCEC	chr1	200617874	Nonsense_Mutation	novel	E284*	0.43
UCEC	chr1	200575637	Missense_Mutation	novel	E1174K	0.42
UCEC	chr1	200600075	Missense_Mutation	novel	K780T	0.33
UCEC	chr1	200553605	Missense_Mutation	NA	S1577Y	0.17
UCEC	chr1	200598329	Missense_Mutation	NA	M819I	0.32
UCEC	chr1	200559388	Missense_Mutation	novel	G1432E	0.12
UCEC	chr1	200598378	Missense_Mutation	novel	L803R	0.18
UCEC	chr1	200603928	Missense_Mutation	rs760556501	D592N	0.15
UCEC	chr1	200617777	Missense_Mutation	novel	R316K	0.13
UCEC	chr1	200618530	Missense_Mutation	NA	R65I	0.14
UCEC	chr1	200618206	Missense_Mutation	NA	S173C	0.4
UCEC	chr1	200590223	Missense_Mutation	novel	M955V	0.24
UCEC	chr1	200618764	5'UTR	novel		0.5
UCEC	chr1	200624974	5'Flank	novel		0.1
UCEC	chr1	200618708	Missense_Mutation	NA	T6A	0.11
UCEC	chr1	200602035	Frame_Shift_Ins	novel	*K671Nfs9**	0.09
UCEC	chr1	200602036	Frame_Shift_Ins	novel	*K671Tfs8**	0.09
UCEC	chr1	200603227	Missense_Mutation	novel	W660R	0.3
UCEC	chr1	200589249	Nonsense_Mutation	rs372514522	R1028*	0.34
UCEC	chr1	200590250	Missense_Mutation	novel	A946T	0.26
UCEC	chr1	200618416	Missense_Mutation	novel	L103P	0.39
UCEC	chr1	200565110	Missense_Mutation	NA	E1344K	0.46
UCEC	chr1	200618702	Missense_Mutation	NA	N8H	0.11
UCEC	chr1	200601899	Missense_Mutation	NA	R717G	0.3
UCEC	chr1	200565151	Missense_Mutation	NA	P1330H	0.17
UCEC	chr1	200589248	Missense_Mutation	rs143052858	R1028Q	0.36
UCEC	chr1	200617736	Missense_Mutation	rs116130210	A330T	0.29
UCEC	chr1	200618436	Silent	novel	R96R	0.36
UCEC	chr1	200618530	Missense_Mutation	NA	R65I	0.28
UCEC	chr1	200565533	Silent	novel	S1266S	0.14
UCEC	chr1	200575675	Missense_Mutation	novel	R1161M	0.15
UCEC	chr1	200603250	Missense_Mutation	novel	P652H	0.2
UCEC	chr1	200617970	Nonsense_Mutation	novel	G252*	0.15
UCEC	chr1	200618626	Missense_Mutation	novel	S33I	0.21
UCEC	chr1	200618781	5'UTR	novel		0.19
UCEC	chr1	200565601	Nonsense_Mutation	novel	E1244*	0.33
UCEC	chr1	200554583	Silent	novel	Q1484Q	0.25
UCEC	chr1	200581202	Missense_Mutation	novel	R1112G	0.36
UCEC	chr1	200565572	Frame_Shift_Del	NA	*F1253Lfs11**	0.24
UCEC	chr1	200618039	Missense_Mutation	rs377722529	V229I	0.15
UCEC	chr1	200618743	5'UTR	novel		0.17
UCEC	chr1	200565182	Silent	novel	L1320L	0.43
UCEC	chr1	200581231	Missense_Mutation	NA	S1102N	0.27
UCEC	chr1	200600103	Nonsense_Mutation	NA	E771*	0.34
UCEC	chr1	200603909	Missense_Mutation	rs373895990	R598Q	0.45
UCEC	chr1	200590224	Missense_Mutation	novel	M954I	0.4
UCEC	chr1	200605890	Missense_Mutation	novel	I538V	0.37
UCEC	chr1	200617869	Silent	novel	H285H	0.09
UCEC	chr1	200553760	Silent	novel	H1525H	0.55
UCS	chr1	200615362	Frame_Shift_Ins	novel	*S454Ifs8**	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0784	0.033566
DLBC	DEL	0.0417	0.0017831
KIRC	AMP	0.0871	0.059566
READ	AMP	0.2606	0.14328
TGCT	AMP	0.3533	0.088103
THCA	AMP	0.0481	0.075436

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0028	Kaplan-Meier Survival Analysis
KIRC	0.00028	Kaplan-Meier Survival Analysis
STAD	0.039	Kaplan-Meier Survival Analysis
SARC	0.027	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.046	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
COAD	0.046	Kaplan-Meier Survival Analysis
PAAD	0.00014	Kaplan-Meier Survival Analysis
PCPG	0.032	Kaplan-Meier Survival Analysis
READ	0.019	Kaplan-Meier Survival Analysis
KICH	0.0083	Kaplan-Meier Survival Analysis
UCEC	0.014	Kaplan-Meier Survival Analysis
LIHC	0.00014	Kaplan-Meier Survival Analysis
CHOL	0.02	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0057	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000118193 (Gene tree)
Gene ID: 9928
Gene Symbol: KIF14
Alias: KIAA0042
Full Name: kinesin family member 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 69,295 bases
Position: chr1:200,551,497-200,620,791
Accession: 19181
RBP type: non-canonical RBP
Summary: This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000367350	KIF14-201	7274	XM_011510231	ENSP00000356319	1648 (aa)	XP_011508533	Q15058
ENST00000614960	KIF14-202	6838	XM_011510232	ENSP00000483069	1648 (aa)	XP_011508534	Q15058

Gene Model

Click here to download ENSG00000118193's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000118193	Lipoprotein(a)	4.6910000E-006	-
ENSG00000118193	Gait	3E-7	26219847

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000118193	rs10800713	1	200579617	A	Tandem gait	26219847	[1.51-3.36] unit decrease	2.431	EFO_0007680

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000118193's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000118193	KIF14	100	71.869	ENSMUSG00000041498	Kif14	100	71.869	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001558	regulation of cell growth	24854087.	IMP	Process
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0005515	protein binding	16431929.16820410.20309963.	IPI	Function
GO:0005524	ATP binding	-	ISS	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005874	microtubule	23209302.	IDA	Component
GO:0005886	plasma membrane	24784001.	IPI	Component
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007019	microtubule depolymerization	-	ISS	Process
GO:0007080	mitotic metaphase plate congression	15843429.	IMP	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008017	microtubule binding	-	ISS	Function
GO:0008284	positive regulation of cell proliferation	24784001.	IDA	Process
GO:0008284	positive regulation of cell proliferation	24854087.	IMP	Process
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	-	ISS	Function
GO:0010389	regulation of G2/M transition of mitotic cell cycle	24854087.	IMP	Process
GO:0015631	tubulin binding	-	ISS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0016887	ATPase activity	-	ISS	Function
GO:0019901	protein kinase binding	16431929.24784001.	IPI	Function
GO:0021685	cerebellar granular layer structural organization	-	ISS	Process
GO:0021693	cerebellar Purkinje cell layer structural organization	-	ISS	Process
GO:0021695	cerebellar cortex development	-	ISS	Process
GO:0021766	hippocampus development	-	ISS	Process
GO:0021772	olfactory bulb development	-	ISS	Process
GO:0021846	cell proliferation in forebrain	-	ISS	Process
GO:0021987	cerebral cortex development	-	ISS	Process
GO:0030155	regulation of cell adhesion	23209302.	IMP	Process
GO:0030165	PDZ domain binding	23209302.	IDA	Function
GO:0030334	regulation of cell migration	23209302.	IMP	Process
GO:0030496	midbody	16431929.20309963.	IDA	Component
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	24854087.	IMP	Process
GO:0031641	regulation of myelination	-	ISS	Process
GO:0032147	activation of protein kinase activity	24784001.	IMP	Process
GO:0032467	positive regulation of cytokinesis	16431929.24854087.	IMP	Process
GO:0032487	regulation of Rap protein signal transduction	23209302.	IMP	Process
GO:0033624	negative regulation of integrin activation	23209302.	IMP	Process
GO:0034446	substrate adhesion-dependent cell spreading	23209302.	IDA	Process
GO:0043066	negative regulation of apoptotic process	24784001.	IMP	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	24854087.	IMP	Process
GO:0043523	regulation of neuron apoptotic process	-	ISS	Process
GO:0043524	negative regulation of neuron apoptotic process	-	ISS	Process
GO:0045184	establishment of protein localization	23209302.	IDA	Process
GO:0051233	spindle midzone	16431929.	IDA	Component
GO:0051301	cell division	-	IEA	Process
GO:0090543	Flemming body	-	IDA	Component
GO:1903429	regulation of cell maturation	-	IEA	Process
GO:2000045	regulation of G1/S transition of mitotic cell cycle	24854087.	IMP	Process

EuRBPDB

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.