EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29749494	Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma.	Oncol Rep	2018 Jul	Bi C	doi: 10.3892/or.2018.6434
23959174	Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β.	Sci Rep	2013	Takahashi RU	doi: 10.1038/srep02474.
25595901	Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.	Oncotarget	2015 Feb 20	Fujita Y	-
24884960	RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.	Mol Cancer	2014 May 31	Tominaga N	doi: 10.1186/1476-4598-13-134.
18724378	RPN2 gene confers docetaxel resistance in breast cancer.	Nat Med	2008 Sep	Honma K	doi: 10.1038/nm.1858.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr20	37210094	Silent	novel	V305V	0.19
BLCA	chr20	37230003	Missense_Mutation	novel	E509K	0.58
BLCA	chr20	37207278	Silent	novel	Q232Q	0.16
BLCA	chr20	37236704	Silent	NA	V626V	0.11
BLCA	chr20	37232366	Nonsense_Mutation	novel	S551*	0.4
BLCA	chr20	37238417	Intron	NA		0.42
BLCA	chr20	37230013	Missense_Mutation	rs151311325	S512L	0.23
BLCA	chr20	37234080	Missense_Mutation	novel	H580Y	0.8
BRCA	chr20	37230057	Nonsense_Mutation	NA	Q527*	0.27
BRCA	chr20	37210161	Missense_Mutation	novel	V328L	0.13
CESC	chr20	37241399	3'UTR	rs747754200		0.5
CESC	chr20	37203884	Splice_Site	novel	X160_splice	0.38
COAD	chr20	37241542	3'UTR	novel		0.35
COAD	chr20	37204794	Frame_Shift_Del	novel	*G196Afs41**	0.12
COAD	chr20	37241400	3'UTR	novel		0.42
COAD	chr20	37238405	Intron	novel		0.28
COAD	chr20	37225745	Silent	rs752016809	F414F	0.16
COAD	chr20	37184332	Missense_Mutation	rs146095088	V56M	0.22
COAD	chr20	37184291	Missense_Mutation	NA	D42G	0.39
COAD	chr20	37241399	3'UTR	rs747754200		0.71
ESCA	chr20	37241347	3'UTR	novel		0.29
ESCA	chr20	37199099	Missense_Mutation	novel	E118V	0.45
ESCA	chr20	37236596	Missense_Mutation	novel	M590I	0.33
ESCA	chr20	37241399	3'UTR	rs747754200		0.47
GBM	chr20	37236665	Silent	rs201803454	T613T	0.47
GBM	chr20	37234021	Missense_Mutation	novel	W560L	0.04
GBM	chr20	37207407	Silent	NA	P275P	0.24
HNSC	chr20	37199169	Silent	novel	S141S	0.04
HNSC	chr20	37210142	Missense_Mutation	novel	Q321H	0.28
HNSC	chr20	37228603	Silent	rs200454814	A451A	0.22
HNSC	chr20	37199104	Missense_Mutation	novel	S120T	0.22
HNSC	chr20	37199105	Nonsense_Mutation	novel	S120*	0.22
HNSC	chr20	37228694	In_Frame_Del	novel	Y482_T489del	0.17
HNSC	chr20	37199202	Silent	novel	L152L	0.35
KIRC	chr20	37213836	Missense_Mutation	NA	D355Y	0.26
KIRC	chr20	37203929	Missense_Mutation	NA	A175G	0.06
KIRP	chr20	37236585	Missense_Mutation	novel	L587M	0.31
LAML	chr20	37207297	Missense_Mutation	rs373475376	A239T	0.08
LGG	chr20	37184179	Splice_Site	novel	X5_splice	0.32
LIHC	chr20	37232323	Frame_Shift_Del	novel	*T539Pfs10**	0.41
LIHC	chr20	37238405	Intron	novel		0.32
LIHC	chr20	37184238	Silent	novel	T24T	0.19
LIHC	chr20	37199147	Missense_Mutation	novel	G134D	0.04
LUAD	chr20	37198490	Nonsense_Mutation	NA	E101*	0.09
LUAD	chr20	37232370	Silent	NA	P552P	0.14
LUAD	chr20	37184235	Silent	novel	L23L	0.09
LUAD	chr20	37184289	Silent	novel	L41L	0.3
LUAD	chr20	37199123	Missense_Mutation	novel	Y126C	0.68
LUAD	chr20	37198404	Missense_Mutation	NA	C72Y	0.08
LUAD	chr20	37203904	Missense_Mutation	NA	T167A	0.24
LUSC	chr20	37238400	Intron	novel		0.18
LUSC	chr20	37228686	Missense_Mutation	novel	Y479F	0.31
LUSC	chr20	37225718	Silent	novel	T405T	0.36
OV	chr20	37203955	In_Frame_Ins	novel	I184delinsKL	0.04
OV	chr20	37203956	In_Frame_Ins	novel	I184_E185insLGSRNLP	0.02
OV	chr20	37234043	Silent	rs757241492	V567V	0.32
OV	chr20	37236627	Missense_Mutation	novel	Q601E	0.03
OV	chr20	37234069	Missense_Mutation	rs755601800	T576M	0.18
OV	chr20	37230042	Missense_Mutation	NA	P522T	0.3
OV	chr20	37207399	Missense_Mutation	novel	V273F	0.19
OV	chr20	37228595	In_Frame_Ins	novel	F449delinsYHRI	0.07
PRAD	chr20	37204795	Missense_Mutation	novel	G195E	0.05
PRAD	chr20	37204887	Missense_Mutation	novel	P226S	0.1
READ	chr20	37228621	Silent	rs747878354	N457N	0.35
READ	chr20	37199113	Missense_Mutation	NA	T123A	0.31
SARC	chr20	37198431	Missense_Mutation	novel	P81L	0.29
SARC	chr20	37230039	Missense_Mutation	novel	T521A	0.21
SKCM	chr20	37184196	Silent	novel	F10F	0.39
SKCM	chr20	37210154	Silent	NA	F325F	0.41
SKCM	chr20	37213817	Silent	novel	F348F	0.31
SKCM	chr20	37232325	Silent	NA	P537P	0.18
SKCM	chr20	37207285	Nonsense_Mutation	NA	Q235*	0.22
SKCM	chr20	37184258	Missense_Mutation	NA	K31R	0.14
SKCM	chr20	37225733	Silent	NA	S410S	0.38
SKCM	chr20	37184200	Silent	NA	L12L	0.13
SKCM	chr20	37236650	Silent	NA	I608I	0.54
SKCM	chr20	37223890	Missense_Mutation	rs138101348	I369F	0.13
SKCM	chr20	37199197	Missense_Mutation	rs147803642	R151C	0.23
SKCM	chr20	37204778	Silent	NA	A189A	0.49
SKCM	chr20	37199158	Missense_Mutation	NA	P138S	0.44
SKCM	chr20	37204892	Silent	NA	S227S	0.34
SKCM	chr20	37228691	Missense_Mutation	novel	L481F	0.3
STAD	chr20	37234064	Silent	NA	P574P	0.06
STAD	chr20	37223881	Missense_Mutation	NA	R366G	0.19
STAD	chr20	37207385	Missense_Mutation	NA	H268R	0.12
STAD	chr20	37228559	Nonsense_Mutation	NA	R437*	0.15
STAD	chr20	37229989	Missense_Mutation	rs139589912	K504R	0.13
STAD	chr20	37228629	Missense_Mutation	NA	K460T	0.09
STAD	chr20	37241399	3'UTR	novel		0.32
STAD	chr20	37234028	Silent	novel	R562R	0.11
STAD	chr20	37184293	Missense_Mutation	rs201593369	R43C	0.09
STAD	chr20	37230014	Silent	rs557396469	S512S	0.23
STAD	chr20	37228711	Silent	NA	D487D	0.13
UCEC	chr20	37203941	Missense_Mutation	novel	S179I	0.43
UCEC	chr20	37241387	3'UTR	novel		0.19
UCEC	chr20	37241399	3'UTR	rs747754200		0.5
UCEC	chr20	37207333	Missense_Mutation	NA	E251K	0.31
UCEC	chr20	37241505	3'UTR	novel		0.07
UCEC	chr20	37228554	Missense_Mutation	NA	F435S	0.55
UCEC	chr20	37210125	Missense_Mutation	rs778793118	R316G	0.37
UCEC	chr20	37213865	Missense_Mutation	novel	E364D	0.38
UCEC	chr20	37234031	Silent	novel	I563I	0.2
UCEC	chr20	37213824	Missense_Mutation	rs114711297	E351K	0.17
UCEC	chr20	37210067	Silent	novel	L296L	0.21
UCEC	chr20	37225745	Silent	rs752016809	F414F	0.47
UCEC	chr20	37229984	Silent	novel	V502V	0.43
UCEC	chr20	37238406	Intron	rs375391019		0.38
UCEC	chr20	37232314	Missense_Mutation	novel	E534Q	0.21
UCEC	chr20	37232370	Silent	rs368527026	P552P	0.38
UCEC	chr20	37200480	Intron	novel		0.34
UCEC	chr20	37213773	Silent	novel	L334L	0.51
UCEC	chr20	37184237	Missense_Mutation	rs755181709	T24M	0.36
UCEC	chr20	37184196	Silent	novel	F10F	0.46
UCEC	chr20	37241557	3'UTR	novel		0.19
UCEC	chr20	37241399	3'UTR	rs747754200		0.56
UCEC	chr20	37241399	3'UTR	rs747754200		0.37
UCEC	chr20	37210069	Missense_Mutation	novel	S297Y	0.38
UCEC	chr20	37213824	Missense_Mutation	rs114711297	E351K	0.45
UCEC	chr20	37204866	Missense_Mutation	rs778332605	M219V	0.27
UCEC	chr20	37241444	3'UTR	novel		0.34
UCEC	chr20	37238409	Intron	novel		0.21
UCEC	chr20	37184286	Silent	rs762745360	S40S	0.54
UCEC	chr20	37213793	Missense_Mutation	novel	K340N	0.38
UCEC	chr20	37199118	Silent	novel	Q124Q	0.54
UCEC	chr20	37207403	Missense_Mutation	NA	V274E	0.39
UCEC	chr20	37204793	Silent	rs368565035	L194L	0.2
UCEC	chr20	37213793	Missense_Mutation	novel	K340N	0.08
UCEC	chr20	37228607	Missense_Mutation	novel	P453S	0.33
UCEC	chr20	37184359	Missense_Mutation	novel	V65M	0.34
UCEC	chr20	37204879	Missense_Mutation	novel	G223E	0.36
UCEC	chr20	37204838	Silent	novel	A209A	0.44
UCEC	chr20	37228714	Silent	NA	A488A	0.57
UCEC	chr20	37241399	3'UTR	rs747754200		0.38
UCEC	chr20	37232392	Splice_Site	novel	X559_splice	0.18
UCEC	chr20	37241399	3'UTR	novel		0.36
UCEC	chr20	37198400	Missense_Mutation	NA	A71S	0.28
UCEC	chr20	37230047	Silent	novel	K523K	0.33
UCEC	chr20	37198431	Missense_Mutation	novel	P81L	0.38
UCS	chr20	37234027	Missense_Mutation	novel	R562L	0.11

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746
READ	AMP	0.8727	7.719e-21

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0067	Kaplan-Meier Survival Analysis
SARC	0.00085	Kaplan-Meier Survival Analysis
MESO	0.0073	Kaplan-Meier Survival Analysis
ACC	0.048	Kaplan-Meier Survival Analysis
HNSC	0.0005	Kaplan-Meier Survival Analysis
LUSC	0.03	Kaplan-Meier Survival Analysis
BRCA	0.046	Kaplan-Meier Survival Analysis
COAD	0.02	Kaplan-Meier Survival Analysis
BLCA	0.00078	Kaplan-Meier Survival Analysis
CESC	0.039	Kaplan-Meier Survival Analysis
KICH	0.016	Kaplan-Meier Survival Analysis
GBM	0.045	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.044	Kaplan-Meier Survival Analysis
UVM	0.00084	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000118705 (Gene tree)
Gene ID: 6185
Gene Symbol: RPN2
Alias: SWP1|RPNII|RIBIIR|RPN-II
Full Name: ribophorin II
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 63,214 bases
Position: chr20:37,178,410-37,241,623
Accession: 10382
RBP type: non-canonical RBP
Summary: This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462163	RPN2-207	712	-	ENSP00000435563	162 (aa)	-	F2Z3K5
ENST00000373632	RPN2-203	1073	-	ENSP00000362735	344 (aa)	-	Q5JYR7
ENST00000373622	RPN2-202	2348	XM_006723851	ENSP00000362724	615 (aa)	XP_006723914	P04844
ENST00000237530	RPN2-201	2515	XM_006723852	ENSP00000237530	631 (aa)	XP_006723915	P04844
ENST00000456400	RPN2-206	453	-	ENSP00000399404	147 (aa)	-	H0Y5M1
ENST00000470352	RPN2-208	511	-	-	- (aa)	-	-
ENST00000456102	RPN2-205	791	-	ENSP00000399137	166 (aa)	-	Q5JYR4
ENST00000437329	RPN2-204	520	-	ENSP00000409580	138 (aa)	-	Q5JYR3

Gene Model

Click here to download ENSG00000118705's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00510	N-Glycan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000118705	Hippocampus	6E-6	19668339

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000118705	rs6031882	20	37181380	?	Hippocampal atrophy	19668339			EFO_0005039
ENSG00000118705	rs74417947	20	37181711	?	Initial pursuit acceleration in psychotic disorders	29064472			EFO_0000692\|EFO_0008434\|EFO_0000289\|EFO_0005411

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000118705's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000118705	RPN2	100	36.471	FBgn0034277	OstDelta	98	33.488	Drosophila_melanogaster
ENSG00000118705	RPN2	100	92.846	ENSMUSG00000027642	Rpn2	100	92.846	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000421	autophagosome membrane	-	IEA	Component
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	21873635.	IBA	Function
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	15835887.	NAS	Function
GO:0005515	protein binding	24965446.29290612.	IPI	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005791	rough endoplasmic reticulum	-	IEA	Component
GO:0006464	cellular protein modification process	10660554.	TAS	Process
GO:0006487	protein N-linked glycosylation	21873635.	IBA	Process
GO:0007568	aging	-	IEA	Process
GO:0008250	oligosaccharyltransferase complex	15835887.	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0018279	protein N-linked glycosylation via asparagine	15835887.	NAS	Process
GO:0018279	protein N-linked glycosylation via asparagine	-	TAS	Process
GO:0042493	response to drug	-	IEA	Process
GO:0043022	ribosome binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.