EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25338120	Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression.	Oncotarget	2014 Oct 30	Benavente CA	-
20400365	Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma.	Oral Oncol	2010 Jul	Waseem A	doi: 10.1016/j.oraloncology.2010.03.022
22157815	The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.	EMBO J	2012 Feb 15	von Eyss B	doi: 10.1038/emboj.2011.451
27302170	Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.	Cancer Res	2016 Oct 1	He X	-
29109788	Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability.	Theranostics	2017 Sep 5	Jia J	doi: 10.7150/thno.21389

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr10	94593550	Nonsense_Mutation	NA	R675*	0.48
BLCA	chr10	94581386	Missense_Mutation	novel	R365C	0.07
BLCA	chr10	94558171	Missense_Mutation	NA	K103N	0.45	ResIII
BLCA	chr10	94593550	Nonsense_Mutation	NA	R675*	0.15
BLCA	chr10	94576680	Missense_Mutation	novel	H303Y	0.46
BLCA	chr10	94592469	Silent	novel	F642F	0.5
BLCA	chr10	94546456	Silent	novel	L37L	0.32
BLCA	chr10	94546469	Missense_Mutation	novel	L42V	0.24
BRCA	chr10	94601743	3'UTR	novel		0.39
BRCA	chr10	94545882	5'UTR	novel		0.56
BRCA	chr10	94592294	Frame_Shift_Del	rs745837238	*R614Efs11**	0.32
BRCA	chr10	94546496	Missense_Mutation	NA	K51Q	0.34
BRCA	chr10	94581377	Missense_Mutation	novel	M362V	0.06
BRCA	chr10	94574153	Missense_Mutation	NA	R224Q	0.36	ResIII
BRCA	chr10	94594813	Missense_Mutation	NA	A736V	0.31
CESC	chr10	94597097	Missense_Mutation	NA	R803Q	0.2
CESC	chr10	94601574	Silent	novel	F823F	0.27
CESC	chr10	94558150	Missense_Mutation	novel	K96N	0.04
COAD	chr10	94594768	Missense_Mutation	NA	R721H	0.38
COAD	chr10	94574167	Missense_Mutation	NA	E229K	0.43	ResIII
COAD	chr10	94601584	Nonsense_Mutation	novel	E827*	0.15
COAD	chr10	94594706	Silent	rs779718210	S700S	0.27
COAD	chr10	94581508	Silent	NA	F405F	0.31
COAD	chr10	94576798	Missense_Mutation	rs770460162	A342V	0.27
COAD	chr10	94545809	5'Flank	novel		0.27
COAD	chr10	94601713	3'UTR	novel		0.3
COAD	chr10	94592435	Missense_Mutation	novel	L631S	0.28
COAD	chr10	94593515	Missense_Mutation	rs772237527	T663M	0.07
COAD	chr10	94571415	Frame_Shift_Del	novel	*K156Rfs27**	0.04	ResIII
COAD	chr10	94558157	Missense_Mutation	novel	K99Q	0.07
COAD	chr10	94590473	Missense_Mutation	NA	N517H	0.12
COAD	chr10	94554130	Missense_Mutation	rs780221772	R53H	0.37
COAD	chr10	94588281	Missense_Mutation	novel	V460A	0.08
COAD	chr10	94558154	Nonsense_Mutation	NA	E98*	0.19
COAD	chr10	94583042	Missense_Mutation	novel	L437V	0.02
COAD	chr10	94545868	5'UTR	novel		0.04
ESCA	chr10	94592428	Missense_Mutation	novel	D629N	0.2
ESCA	chr10	94592294	Frame_Shift_Del	rs745837238	*R614Efs11**	0.38
GBM	chr10	94574019	Silent	rs748488487	S179S	0.42
HNSC	chr10	94588305	Frame_Shift_Del	novel	*Y469Mfs16**	0.3
HNSC	chr10	94576699	Missense_Mutation	novel	R309H	0.13
HNSC	chr10	94583057	Nonsense_Mutation	novel	Q442*	0.39
HNSC	chr10	94590453	Missense_Mutation	novel	R510L	0.18
HNSC	chr10	94562814	Frame_Shift_Del	novel	M125*	0.3	ResIII
HNSC	chr10	94546374	Splice_Region	rs750089727		0.17
KIRC	chr10	94592393	Splice_Site	NA	X618_splice	0.14
KIRC	chr10	94590504	Missense_Mutation	NA	E527A	0.2
KIRP	chr10	94545866	5'UTR	rs191227493		0.29
LAML	chr10	94574186	Missense_Mutation	novel	R235M	0.14	ResIII
LAML	chr10	94592293	Missense_Mutation	novel	L611Q	0.08
LGG	chr10	94574672	Missense_Mutation	novel	L275P	0.2
LGG	chr10	94558155	Frame_Shift_Del	novel	*K99Nfs9**	0.3
LGG	chr10	94597097	Missense_Mutation	NA	R803Q	0.46
LGG	chr10	94592484	Silent	NA	G647G	0.21
LIHC	chr10	94590532	Silent	novel	Q536Q	0.19
LIHC	chr10	94590452	Nonsense_Mutation	NA	R510*	0.04
LUAD	chr10	94546408	Silent	NA	L21L	0.63
LUAD	chr10	94590437	Missense_Mutation	NA	T505A	0.61
LUAD	chr10	94546425	Missense_Mutation	novel	T27S	0.23
LUAD	chr10	94574093	Missense_Mutation	NA	K204R	0.14	ResIII
LUAD	chr10	94574109	Silent	novel	P209P	0.37
LUAD	chr10	94601647	3'UTR	novel		0.3
LUAD	chr10	94601621	Nonstop_Mutation	NA	839Lext6	0.15
LUAD	chr10	94581397	Silent	NA	R368R	0.39
LUSC	chr10	94546468	Silent	novel	G41G	0.2
LUSC	chr10	94562709	Missense_Mutation	novel	A118S	0.31	ResIII
LUSC	chr10	94574166	Silent	novel	V228V	0.48
LUSC	chr10	94574137	Missense_Mutation	novel	T219S	0.12	ResIII
LUSC	chr10	94592243	Missense_Mutation	novel	L594F	0.11
LUSC	chr10	94592244	Missense_Mutation	novel	V595L	0.1
LUSC	chr10	94546483	Silent	novel	R46R	0.09
LUSC	chr10	94592474	Missense_Mutation	novel	R644M	0.22
MESO	chr10	94574606	Missense_Mutation	NA	G253D	0.2
OV	chr10	94581479	Silent	NA	L396L	0.18
PAAD	chr10	94592238	Nonsense_Mutation	novel	E593*	0.18
PRAD	chr10	94571393	Missense_Mutation	novel	I147M	0.18	ResIII
READ	chr10	94554224	Silent	NA	T84T	0.18
READ	chr10	94590456	Missense_Mutation	rs372532589	R511Q	0.29
READ	chr10	94592507	Frame_Shift_Del	novel	*N657Tfs15**	0.1
READ	chr10	94576792	Missense_Mutation	novel	R340Q	0.39
SARC	chr10	94554223	Missense_Mutation	rs752164311	T84M	0.33
SKCM	chr10	94581412	Silent	novel	F373F	0.36
SKCM	chr10	94554161	Silent	novel	I63I	0.31
SKCM	chr10	94590659	Silent	novel	I550I	0.44
SKCM	chr10	94588346	Missense_Mutation	NA	A482T	0.19
SKCM	chr10	94574018	Missense_Mutation	rs781780355	S179L	0.1	ResIII
SKCM	chr10	94594769	Silent	NA	R721R	0.08
SKCM	chr10	94573984	Missense_Mutation	NA	L168F	0.39	ResIII
SKCM	chr10	94592306	Silent	NA	G615G	0.16
SKCM	chr10	94574083	Missense_Mutation	NA	P201S	0.37	ResIII
SKCM	chr10	94574074	Missense_Mutation	novel	F198V	0.15	ResIII
SKCM	chr10	94574075	Missense_Mutation	novel	F198S	0.16	ResIII
SKCM	chr10	94590711	Missense_Mutation	NA	R568C	0.44
SKCM	chr10	94554230	Missense_Mutation	novel	M86I	0.24
SKCM	chr10	94554231	Missense_Mutation	novel	E87K	0.24
STAD	chr10	94593600	Silent	novel	I691I	0.1
STAD	chr10	94574164	Missense_Mutation	NA	V228I	0.16	ResIII
STAD	chr10	94576728	Missense_Mutation	rs555694666	R319W	0.08
STAD	chr10	94592294	Frame_Shift_Del	rs745837238	*R614Efs11**	0.32
STAD	chr10	94554165	Missense_Mutation	NA	Y65H	0.06
STAD	chr10	94594726	Missense_Mutation	NA	R707K	0.47
STAD	chr10	94554126	Missense_Mutation	novel	A52T	0.24
STAD	chr10	94592293	Frame_Shift_Ins	NA	*R614Kfs33**	0.27
STAD	chr10	94592294	Frame_Shift_Del	rs745837238	*R614Efs11**	0.49
STAD	chr10	94592495	Missense_Mutation	NA	Y651C	0.2
STAD	chr10	94590770	Silent	NA	E587E	0.39
STAD	chr10	94592507	Frame_Shift_Del	novel	*N657Tfs15**	0.34
STAD	chr10	94546377	Missense_Mutation	NA	G11D	0.26
STAD	chr10	94588243	Silent	NA	F447F	0.28
THCA	chr10	94601571	Missense_Mutation	NA	I822M	0.14
UCEC	chr10	94574018	Missense_Mutation	rs781780355	S179L	0.45	ResIII
UCEC	chr10	94596902	Missense_Mutation	NA	N764T	0.34
UCEC	chr10	94601559	Missense_Mutation	NA	E818D	0.24
UCEC	chr10	94583009	Missense_Mutation	NA	D426Y	0.35
UCEC	chr10	94546473	Missense_Mutation	novel	E43G	0.07
UCEC	chr10	94562823	Missense_Mutation	novel	K128Q	0.19	ResIII
UCEC	chr10	94571425	Missense_Mutation	novel	N158T	0.43	ResIII
UCEC	chr10	94588304	Missense_Mutation	novel	V468I	0.37
UCEC	chr10	94594791	Missense_Mutation	NA	D729N	0.42
UCEC	chr10	94596929	Missense_Mutation	novel	E773G	0.06
UCEC	chr10	94601559	Missense_Mutation	NA	E818D	0.36
UCEC	chr10	94601805	3'UTR	novel		0.37
UCEC	chr10	94588304	Missense_Mutation	novel	V468I	0.28
UCEC	chr10	94596922	Missense_Mutation	novel	L771V	0.36
UCEC	chr10	94590711	Missense_Mutation	NA	R568C	0.19
UCEC	chr10	94562697	Missense_Mutation	NA	N114H	0.43	ResIII
UCEC	chr10	94596900	Missense_Mutation	NA	K763N	0.17
UCEC	chr10	94597097	Missense_Mutation	NA	R803Q	0.36
UCEC	chr10	94554220	Missense_Mutation	novel	L83S	0.33
UCEC	chr10	94576668	Missense_Mutation	rs761675110	T299A	0.34
UCEC	chr10	94546425	Missense_Mutation	novel	T27I	0.3
UCEC	chr10	94576738	Missense_Mutation	novel	T322N	0.25
UCEC	chr10	94594756	Missense_Mutation	novel	V717A	0.4
UCEC	chr10	94571406	Frame_Shift_Del	rs775038246	*N154Ifs29**	0.42	ResIII
UCEC	chr10	94558174	Missense_Mutation	novel	K104N	0.51	ResIII
UCEC	chr10	94573996	Missense_Mutation	novel	D172Y	0.47	ResIII
UCEC	chr10	94577081	Intron	novel		0.43
UCEC	chr10	94581408	Missense_Mutation	rs771730256	R372Q	0.4
UCEC	chr10	94592231	Splice_Region	rs147829794	I590I	0.61
UCEC	chr10	94592452	Missense_Mutation	novel	L637I	0.52
UCEC	chr10	94584039	Intron	novel		0.48
UCEC	chr10	94592471	Missense_Mutation	NA	S643N	0.43
UCEC	chr10	94574725	Missense_Mutation	novel	F293L	0.38
UCEC	chr10	94581487	Missense_Mutation	NA	N398K	0.04
UCEC	chr10	94574019	Silent	rs748488487	S179S	0.17
UCEC	chr10	94588263	Missense_Mutation	novel	S454Y	0.15
UCEC	chr10	94596906	Missense_Mutation	novel	F765L	0.35
UCEC	chr10	94576799	Silent	rs373919239	A342A	0.16
UCEC	chr10	94594791	Missense_Mutation	NA	D729N	0.24
UCEC	chr10	94574090	Missense_Mutation	novel	R203Q	0.44	ResIII
UCEC	chr10	94574656	Missense_Mutation	novel	V270L	0.35
UCEC	chr10	94597096	Nonsense_Mutation	novel	R803*	0.08
UCEC	chr10	94601808	3'UTR	novel		0.35
UCEC	chr10	94574656	Missense_Mutation	novel	V270I	0.39
UCEC	chr10	94574018	Missense_Mutation	rs781780355	S179L	0.11	ResIII
UCEC	chr10	94545915	5'UTR	novel		0.31
UCEC	chr10	94597097	Missense_Mutation	NA	R803Q	0.45
UCEC	chr10	94558154	Frame_Shift_Ins	novel	*L100Ifs11**	0.41
UCEC	chr10	94581332	Missense_Mutation	novel	Y347H	0.12
UCEC	chr10	94590729	Missense_Mutation	novel	P574S	0.19
UCEC	chr10	94601574	Missense_Mutation	novel	F823L	0.19
UCEC	chr10	94592514	Splice_Region	rs145577611	N657N	0.16
UCEC	chr10	94594752	Missense_Mutation	NA	P716S	0.16
UCEC	chr10	94583030	Nonsense_Mutation	novel	E433*	0.43
UCEC	chr10	94594791	Missense_Mutation	NA	D729N	0.31
UCS	chr10	94592294	Frame_Shift_Del	rs745837238	*R614Efs11**	0.55
UCS	chr10	94594801	Missense_Mutation	novel	I732S	0.16

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.1667	0.048655
COAD	DEL	0.1752	9.4741e-07
MESO	DEL	0.2644	0.00015289
PAAD	DEL	0.1304	0.169
READ	DEL	0.2364	0.014135
THCA	DEL	0.016	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.3036	0.1218

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0016	Kaplan-Meier Survival Analysis
KIRC	0.00021	Kaplan-Meier Survival Analysis
STAD	0.015	Kaplan-Meier Survival Analysis
SARC	0.0039	Kaplan-Meier Survival Analysis
MESO	0.00018	Kaplan-Meier Survival Analysis
UCS	0.017	Kaplan-Meier Survival Analysis
PRAD	0.0073	Kaplan-Meier Survival Analysis
LUSC	0.00015	Kaplan-Meier Survival Analysis
KIRP	0.00015	Kaplan-Meier Survival Analysis
PAAD	0.03	Kaplan-Meier Survival Analysis
PCPG	0.031	Kaplan-Meier Survival Analysis
BLCA	0.018	Kaplan-Meier Survival Analysis
CESC	0.00037	Kaplan-Meier Survival Analysis
LIHC	0.00031	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.00037	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119969 (Gene tree)
Gene ID: 3070
Gene Symbol: HELLS
Alias: PASG|SMARCA6|LSH|Nbla10143
Full Name: helicase, lymphoid specific
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 112,472 bases
Position: chr10:94,501,434-94,613,905
Accession: 4861
RBP type: canonical RBP
Summary: This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000239027	ResIII	PF04851.15	4.7e-07	1	1
ENSP00000377601	ResIII	PF04851.15	5.1e-07	1	1
ENSP00000239026	ResIII	PF04851.15	8.5e-07	1	1
ENSP00000360383	ResIII	PF04851.15	1.2e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000394036	HELLS-205	3131	XM_024447968	ENSP00000377601	884 (aa)	XP_024303736	A0A0B4J1V9
ENST00000239026	HELLS-201	2740	-	ENSP00000239026	714 (aa)	-	F6XU50
ENST00000394045	HELLS-206	2699	-	ENSP00000377609	740 (aa)	-	Q9NRZ9
ENST00000462057	HELLS-208	778	-	-	- (aa)	-	-
ENST00000371327	HELLS-203	4987	-	ENSP00000360378	310 (aa)	-	Q9NW36
ENST00000475263	HELLS-211	676	-	-	- (aa)	-	-
ENST00000371332	HELLS-204	2675	XM_024447967	ENSP00000360383	700 (aa)	XP_024303735	A0A087WSW7
ENST00000419900	HELLS-207	711	-	ENSP00000409945	192 (aa)	-	B1ALG6
ENST00000464030	HELLS-209	321	-	-	- (aa)	-	-
ENST00000466552	HELLS-210	2724	-	-	- (aa)	-	-
ENST00000348459	HELLS-202	3099	-	ENSP00000239027	838 (aa)	-	Q9NRZ9
ENST00000630929	HELLS-212	400	-	ENSP00000485823	97 (aa)	-	Q76H82

Gene Model

Click here to download ENSG00000119969's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000119969	Platelet Function Tests	2.9629600E-005	-
ENSG00000119969	Platelet Function Tests	1.7678900E-005	-
ENSG00000119969	Platelet Function Tests	1.5971000E-014	-
ENSG00000119969	Platelet Function Tests	1.5412000E-005	-
ENSG00000119969	Platelet Function Tests	1.0675000E-009	-
ENSG00000119969	Platelet Function Tests	8.5210000E-020	-
ENSG00000119969	Platelet Function Tests	6.9110000E-006	-
ENSG00000119969	Platelet Function Tests	1.7441000E-021	-
ENSG00000119969	Platelet Function Tests	3.1219000E-010	-
ENSG00000119969	Platelet Function Tests	4.3392000E-023	-
ENSG00000119969	Platelet Function Tests	1.4317000E-014	-
ENSG00000119969	Platelet Function Tests	1.9290000E-007	-
ENSG00000119969	Platelet Function Tests	1.1098000E-017	-
ENSG00000119969	Platelet Function Tests	9.0377000E-012	-
ENSG00000119969	Platelet Function Tests	2.3708000E-007	-
ENSG00000119969	Platelet Function Tests	1.5236000E-014	-
ENSG00000119969	Anticoagulants	8E-12	19578179
ENSG00000119969	platelet adhesion inhibitor	2E-13	19706858
ENSG00000119969	Anticoagulants	5E-12	23755828

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000119969	rs7078811	10	94596424	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119969's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000119969	HELLS	67	47.000	ENSG00000080503	SMARCA2	78	37.912
ENSG00000119969	HELLS	69	47.500	ENSG00000127616	SMARCA4	91	35.589
ENSG00000119969	HELLS	85	42.804	ENSG00000173575	CHD2	86	61.856

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119969	HELLS	98	67.831	ENSAPOG00000007707	hells	99	63.321	Acanthochromis_polyacanthus
ENSG00000119969	HELLS	100	96.499	ENSAMEG00000013525	HELLS	100	95.232	Ailuropoda_melanoleuca
ENSG00000119969	HELLS	96	68.129	ENSACIG00000018996	hells	99	66.949	Amphilophus_citrinellus
ENSG00000119969	HELLS	98	67.994	ENSAOCG00000006348	hells	97	65.175	Amphiprion_ocellaris
ENSG00000119969	HELLS	99	67.327	ENSAPEG00000001422	hells	97	64.692	Amphiprion_percula
ENSG00000119969	HELLS	99	68.058	ENSATEG00000008107	hells	99	63.313	Anabas_testudineus
ENSG00000119969	HELLS	99	84.158	ENSAPLG00000002649	HELLS	99	82.188	Anas_platyrhynchos
ENSG00000119969	HELLS	99	75.910	ENSACAG00000028785	HELLS	96	75.728	Anolis_carolinensis
ENSG00000119969	HELLS	100	97.199	ENSANAG00000034765	-	100	96.778	Aotus_nancymaae
ENSG00000119969	HELLS	99	66.808	ENSACLG00000007613	hells	99	63.827	Astatotilapia_calliptera
ENSG00000119969	HELLS	95	69.624	ENSAMXG00000002088	hells	99	68.143	Astyanax_mexicanus
ENSG00000119969	HELLS	96	94.635	ENSBTAG00000005979	HELLS	100	94.635	Bos_taurus
ENSG00000119969	HELLS	100	97.619	ENSCJAG00000015819	HELLS	100	97.136	Callithrix_jacchus
ENSG00000119969	HELLS	99	96.634	ENSCAFG00000008090	HELLS	100	94.756	Canis_familiaris
ENSG00000119969	HELLS	100	96.639	ENSCAFG00020004809	HELLS	98	96.188	Canis_lupus_dingo
ENSG00000119969	HELLS	100	93.120	ENSCHIG00000019462	HELLS	100	90.931	Capra_hircus
ENSG00000119969	HELLS	100	94.000	ENSTSYG00000005811	-	100	94.000	Carlito_syrichta
ENSG00000119969	HELLS	100	93.697	ENSCPOG00000003043	HELLS	100	93.198	Cavia_porcellus
ENSG00000119969	HELLS	65	97.688	ENSCCAG00000026761	HELLS	99	97.688	Cebus_capucinus
ENSG00000119969	HELLS	100	98.880	ENSCATG00000033830	HELLS	100	98.880	Cercocebus_atys
ENSG00000119969	HELLS	100	94.258	ENSCLAG00000003938	HELLS	100	93.674	Chinchilla_lanigera
ENSG00000119969	HELLS	100	98.739	ENSCSAG00000006181	HELLS	100	98.739	Chlorocebus_sabaeus
ENSG00000119969	HELLS	100	82.402	ENSCPBG00000025739	HELLS	99	84.195	Chrysemys_picta_bellii
ENSG00000119969	HELLS	100	98.880	ENSCANG00000037736	HELLS	100	98.880	Colobus_angolensis_palliatus
ENSG00000119969	HELLS	100	92.437	ENSCGRG00001017410	Hells	100	90.268	Cricetulus_griseus_chok1gshd
ENSG00000119969	HELLS	98	67.201	ENSCSEG00000016985	hells	99	65.000	Cynoglossus_semilaevis
ENSG00000119969	HELLS	73	63.760	ENSCVAG00000000159	hells	96	63.760	Cyprinodon_variegatus
ENSG00000119969	HELLS	99	68.531	ENSDARG00000057738	hells	97	65.714	Danio_rerio
ENSG00000119969	HELLS	90	95.577	ENSDNOG00000017758	HELLS	100	95.577	Dasypus_novemcinctus
ENSG00000119969	HELLS	100	92.997	ENSDORG00000011812	Hells	100	91.885	Dipodomys_ordii
ENSG00000119969	HELLS	70	63.534	ENSEBUG00000016152	hells	93	53.070	Eptatretus_burgeri
ENSG00000119969	HELLS	100	96.779	ENSEASG00005011764	HELLS	100	95.232	Equus_asinus_asinus
ENSG00000119969	HELLS	100	96.499	ENSECAG00000018810	HELLS	100	95.107	Equus_caballus
ENSG00000119969	HELLS	82	96.739	ENSEEUG00000007680	HELLS	91	96.739	Erinaceus_europaeus
ENSG00000119969	HELLS	99	66.761	ENSELUG00000014909	hells	93	64.532	Esox_lucius
ENSG00000119969	HELLS	100	96.919	ENSFCAG00000005206	HELLS	100	96.919	Felis_catus
ENSG00000119969	HELLS	99	82.725	ENSFALG00000007136	HELLS	99	81.387	Ficedula_albicollis
ENSG00000119969	HELLS	100	94.118	ENSFDAG00000010042	HELLS	100	93.187	Fukomys_damarensis
ENSG00000119969	HELLS	99	65.823	ENSFHEG00000022950	hells	97	64.613	Fundulus_heteroclitus
ENSG00000119969	HELLS	99	83.046	ENSGALG00000005451	HELLS	100	83.262	Gallus_gallus
ENSG00000119969	HELLS	99	66.284	ENSGAFG00000001204	hells	97	62.441	Gambusia_affinis
ENSG00000119969	HELLS	99	66.008	ENSGACG00000003897	hells	91	64.796	Gasterosteus_aculeatus
ENSG00000119969	HELLS	99	83.597	ENSGAGG00000010269	HELLS	100	83.811	Gopherus_agassizii
ENSG00000119969	HELLS	100	99.714	ENSGGOG00000008103	HELLS	100	99.714	Gorilla_gorilla
ENSG00000119969	HELLS	99	67.137	ENSHBUG00000010270	hells	99	63.827	Haplochromis_burtoni
ENSG00000119969	HELLS	85	90.798	ENSHGLG00000006537	-	100	90.798	Heterocephalus_glaber_female
ENSG00000119969	HELLS	100	94.678	ENSHGLG00000011377	-	100	94.039	Heterocephalus_glaber_female
ENSG00000119969	HELLS	100	94.398	ENSHGLG00100017230	-	100	93.796	Heterocephalus_glaber_male
ENSG00000119969	HELLS	99	84.507	ENSHGLG00100001957	-	95	83.539	Heterocephalus_glaber_male
ENSG00000119969	HELLS	99	66.008	ENSHCOG00000001119	hells	96	66.008	Hippocampus_comes
ENSG00000119969	HELLS	99	66.946	ENSIPUG00000002634	HELLS	97	63.571	Ictalurus_punctatus
ENSG00000119969	HELLS	100	96.078	ENSSTOG00000021976	HELLS	100	94.891	Ictidomys_tridecemlineatus
ENSG00000119969	HELLS	98	92.117	ENSJJAG00000000865	Hells	99	87.117	Jaculus_jaculus
ENSG00000119969	HELLS	99	67.482	ENSKMAG00000017279	hells	97	64.916	Kryptolebias_marmoratus
ENSG00000119969	HELLS	99	68.688	ENSLBEG00000027807	hells	96	65.259	Labrus_bergylta
ENSG00000119969	HELLS	100	95.798	ENSLAFG00000007049	HELLS	100	95.255	Loxodonta_africana
ENSG00000119969	HELLS	100	98.880	ENSMFAG00000044053	HELLS	100	98.807	Macaca_fascicularis
ENSG00000119969	HELLS	100	98.492	ENSMMUG00000017255	HELLS	100	98.846	Macaca_mulatta
ENSG00000119969	HELLS	100	98.880	ENSMNEG00000042628	HELLS	100	98.880	Macaca_nemestrina
ENSG00000119969	HELLS	100	98.880	ENSMLEG00000041751	HELLS	100	98.807	Mandrillus_leucophaeus
ENSG00000119969	HELLS	99	66.810	ENSMAMG00000009850	hells	98	67.438	Mastacembelus_armatus
ENSG00000119969	HELLS	99	67.137	ENSMZEG00005018414	hells	99	63.827	Maylandia_zebra
ENSG00000119969	HELLS	99	82.566	ENSMGAG00000006818	HELLS	97	83.258	Meleagris_gallopavo
ENSG00000119969	HELLS	100	92.297	ENSMAUG00000021941	Hells	97	89.850	Mesocricetus_auratus
ENSG00000119969	HELLS	82	93.728	ENSMICG00000046554	-	95	93.728	Microcebus_murinus
ENSG00000119969	HELLS	100	92.717	ENSMOCG00000019342	Hells	100	90.024	Microtus_ochrogaster
ENSG00000119969	HELLS	99	63.239	ENSMMOG00000007950	hells	97	60.684	Mola_mola
ENSG00000119969	HELLS	100	86.592	ENSMODG00000005589	-	51	85.607	Monodelphis_domestica
ENSG00000119969	HELLS	99	65.867	ENSMALG00000010244	hells	94	61.481	Monopterus_albus
ENSG00000119969	HELLS	100	92.717	MGP_CAROLIEiJ_G0022930	Hells	100	91.241	Mus_caroli
ENSG00000119969	HELLS	100	92.577	ENSMUSG00000025001	Hells	100	91.241	Mus_musculus
ENSG00000119969	HELLS	100	93.277	MGP_PahariEiJ_G0014423	Hells	100	92.092	Mus_pahari
ENSG00000119969	HELLS	100	93.137	MGP_SPRETEiJ_G0023848	Hells	100	91.484	Mus_spretus
ENSG00000119969	HELLS	100	96.078	ENSMPUG00000017131	HELLS	100	94.749	Mustela_putorius_furo
ENSG00000119969	HELLS	100	92.997	ENSMLUG00000030511	HELLS	100	90.931	Myotis_lucifugus
ENSG00000119969	HELLS	100	92.437	ENSNGAG00000014049	Hells	100	91.169	Nannospalax_galili
ENSG00000119969	HELLS	99	62.623	ENSNBRG00000024242	hells	99	60.494	Neolamprologus_brichardi
ENSG00000119969	HELLS	100	99.580	ENSNLEG00000012987	HELLS	100	99.580	Nomascus_leucogenys
ENSG00000119969	HELLS	100	91.737	ENSODEG00000015916	HELLS	100	90.334	Octodon_degus
ENSG00000119969	HELLS	99	66.763	ENSONIG00000013166	hells	97	63.886	Oreochromis_niloticus
ENSG00000119969	HELLS	100	86.014	ENSOANG00000005139	HELLS	100	85.351	Ornithorhynchus_anatinus
ENSG00000119969	HELLS	100	95.938	ENSOCUG00000026731	HELLS	100	94.272	Oryctolagus_cuniculus
ENSG00000119969	HELLS	99	67.001	ENSORLG00000000987	hells	97	63.787	Oryzias_latipes
ENSG00000119969	HELLS	99	66.858	ENSORLG00020003952	hells	97	63.603	Oryzias_latipes_hni
ENSG00000119969	HELLS	99	66.955	ENSORLG00015010960	hells	96	64.423	Oryzias_latipes_hsok
ENSG00000119969	HELLS	99	66.428	ENSOMEG00000000135	hells	95	64.115	Oryzias_melastigma
ENSG00000119969	HELLS	100	95.238	ENSOGAG00000017145	HELLS	99	94.203	Otolemur_garnettii
ENSG00000119969	HELLS	100	94.678	ENSOARG00000004495	HELLS	100	93.675	Ovis_aries
ENSG00000119969	HELLS	100	100.000	ENSPPAG00000001726	HELLS	100	99.774	Pan_paniscus
ENSG00000119969	HELLS	100	96.919	ENSPPRG00000005839	HELLS	100	96.919	Panthera_pardus
ENSG00000119969	HELLS	100	96.919	ENSPTIG00000007647	HELLS	100	96.919	Panthera_tigris_altaica
ENSG00000119969	HELLS	100	100.000	ENSPTRG00000002778	HELLS	100	99.774	Pan_troglodytes
ENSG00000119969	HELLS	100	98.880	ENSPANG00000033528	HELLS	100	98.880	Papio_anubis
ENSG00000119969	HELLS	99	66.573	ENSPKIG00000010890	hells	99	62.909	Paramormyrops_kingsleyae
ENSG00000119969	HELLS	99	83.567	ENSPSIG00000005462	HELLS	100	82.093	Pelodiscus_sinensis
ENSG00000119969	HELLS	99	66.092	ENSPMGG00000014690	hells	98	66.715	Periophthalmus_magnuspinnatus
ENSG00000119969	HELLS	100	85.938	ENSPEMG00000017579	Hells	100	90.962	Peromyscus_maniculatus_bairdii
ENSG00000119969	HELLS	99	62.915	ENSPMAG00000004376	hells	98	60.491	Petromyzon_marinus
ENSG00000119969	HELLS	100	86.592	ENSPCIG00000013361	HELLS	100	85.375	Phascolarctos_cinereus
ENSG00000119969	HELLS	99	65.571	ENSPFOG00000001954	hells	97	62.307	Poecilia_formosa
ENSG00000119969	HELLS	99	65.423	ENSPLAG00000006504	hells	97	64.034	Poecilia_latipinna
ENSG00000119969	HELLS	99	65.567	ENSPMEG00000003024	hells	97	64.175	Poecilia_mexicana
ENSG00000119969	HELLS	99	65.280	ENSPREG00000020337	hells	97	62.069	Poecilia_reticulata
ENSG00000119969	HELLS	100	99.479	ENSPPYG00000002502	HELLS	100	99.434	Pongo_abelii
ENSG00000119969	HELLS	99	91.631	ENSPCAG00000013618	HELLS	100	87.709	Procavia_capensis
ENSG00000119969	HELLS	100	96.359	ENSPCOG00000023985	HELLS	100	96.143	Propithecus_coquereli
ENSG00000119969	HELLS	92	97.790	ENSPVAG00000017899	HELLS	92	97.790	Pteropus_vampyrus
ENSG00000119969	HELLS	99	65.297	ENSPNYG00000009100	hells	99	62.546	Pundamilia_nyererei
ENSG00000119969	HELLS	96	67.153	ENSPNAG00000029968	hells	96	64.025	Pygocentrus_nattereri
ENSG00000119969	HELLS	100	93.277	ENSRNOG00000047104	Hells	100	91.647	Rattus_norvegicus
ENSG00000119969	HELLS	100	93.277	ENSRNOG00000047692	LOC100911660	100	92.092	Rattus_norvegicus
ENSG00000119969	HELLS	100	98.250	ENSRBIG00000041080	HELLS	100	97.547	Rhinopithecus_bieti
ENSG00000119969	HELLS	100	98.739	ENSRROG00000040169	HELLS	100	98.739	Rhinopithecus_roxellana
ENSG00000119969	HELLS	99	86.713	ENSSHAG00000014358	HELLS	99	86.520	Sarcophilus_harrisii
ENSG00000119969	HELLS	99	68.864	ENSSFOG00015017895	hells	98	66.667	Scleropages_formosus
ENSG00000119969	HELLS	99	67.482	ENSSMAG00000017423	hells	99	63.333	Scophthalmus_maximus
ENSG00000119969	HELLS	99	67.770	ENSSDUG00000016924	hells	99	63.861	Seriola_dumerili
ENSG00000119969	HELLS	99	65.274	ENSSLDG00000018960	hells	94	63.379	Seriola_lalandi_dorsalis
ENSG00000119969	HELLS	100	80.559	ENSSPUG00000017425	HELLS	100	80.528	Sphenodon_punctatus
ENSG00000119969	HELLS	96	68.601	ENSSPAG00000015579	hells	99	66.667	Stegastes_partitus
ENSG00000119969	HELLS	100	95.798	ENSSSCG00000010486	HELLS	100	94.988	Sus_scrofa
ENSG00000119969	HELLS	99	83.497	ENSTGUG00000007157	HELLS	99	81.576	Taeniopygia_guttata
ENSG00000119969	HELLS	99	67.792	ENSTRUG00000000350	hells	97	64.839	Takifugu_rubripes
ENSG00000119969	HELLS	88	71.429	ENSTNIG00000003738	hells	98	57.745	Tetraodon_nigroviridis
ENSG00000119969	HELLS	100	95.518	ENSUAMG00000003343	HELLS	100	94.769	Ursus_americanus
ENSG00000119969	HELLS	100	96.359	ENSUMAG00000004748	HELLS	99	95.785	Ursus_maritimus
ENSG00000119969	HELLS	99	93.961	ENSVPAG00000010115	HELLS	100	93.079	Vicugna_pacos
ENSG00000119969	HELLS	100	96.639	ENSVVUG00000022808	HELLS	100	95.107	Vulpes_vulpes
ENSG00000119969	HELLS	99	65.896	ENSXCOG00000013840	hells	99	61.446	Xiphophorus_couchianus
ENSG00000119969	HELLS	99	65.854	ENSXMAG00000005731	hells	98	64.888	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000775	chromosome, centromeric region	-	ISS	Component
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	22157815.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005721	pericentric heterochromatin	-	ISS	Component
GO:0006346	methylation-dependent chromatin silencing	-	ISS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007275	multicellular organism development	-	ISS	Process
GO:0010216	maintenance of DNA methylation	-	ISS	Process
GO:0031508	pericentric heterochromatin assembly	-	ISS	Process
GO:0046651	lymphocyte proliferation	-	ISS	Process
GO:0051301	cell division	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.