EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28455244	GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells.	Cancer Lett	2017 Aug 1	Abrego J	doi: 10.1016/j.canlet.2017.04.029
29751795	Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose.	BMC Cancer	2018 May 11	Zhou X	doi: 10.1186/s12885-018-4443-1.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	99430583	5'UTR	novel		0.39
BLCA	chr10	99430568	5'UTR	novel		0.13
BLCA	chr10	99420721	Missense_Mutation	novel	N68T	0.19
BLCA	chr10	99430571	5'UTR	novel		0.45
BLCA	chr10	99397428	3'UTR	novel		0.26
BLCA	chr10	99420670	Missense_Mutation	novel	S85F	0.39
BRCA	chr10	99430600	5'Flank	novel		0.22
BRCA	chr10	99430590	5'UTR	rs778400032		0.31
CESC	chr10	99420796	Missense_Mutation	rs377247241	T43M	0.13
CESC	chr10	99403473	Missense_Mutation	novel	E319K	0.34
CESC	chr10	99406166	Missense_Mutation	novel	D170N	0.19
CESC	chr10	99403838	Nonsense_Mutation	NA	Q227*	0.67
CESC	chr10	99402680	Missense_Mutation	rs776949680	M334I	0.27
CESC	chr10	99406779	In_Frame_Del	novel	R122_Y124del	0.31
COAD	chr10	99397629	Missense_Mutation	NA	R387Q	0.32
COAD	chr10	99406139	Missense_Mutation	NA	E179K	0.29
COAD	chr10	99403830	Missense_Mutation	novel	F229L	0.45
COAD	chr10	99402650	Silent	NA	A344A	0.12
COAD	chr10	99406824	Frame_Shift_Del	novel	*G109Efs12**	0.39
COAD	chr10	99397617	Missense_Mutation	NA	S391N	0.44
COAD	chr10	99397533	3'UTR	rs368527371		0.39
COAD	chr10	99403570	Silent	NA	S286S	0.45
COAD	chr10	99420671	Missense_Mutation	novel	S85A	0.09
COAD	chr10	99397472	3'UTR	novel		0.1
COAD	chr10	99403734	Silent	NA	F261F	0.33
COAD	chr10	99402674	Silent	NA	S336S	0.34
GBM	chr10	99397352	3'UTR	novel		0.5
GBM	chr10	99406157	Missense_Mutation	novel	G173S	0.11
GBM	chr10	99406159	Missense_Mutation	novel	Q172R	0.08
GBM	chr10	99430588	5'UTR	novel		0.64
GBM	chr10	99420739	Missense_Mutation	novel	A62V	0.06
GBM	chr10	99397644	Missense_Mutation	novel	L382Q	0.15
GBM	chr10	99402695	Missense_Mutation	novel	D329E	0.83
GBM	chr10	99420701	Missense_Mutation	novel	L75M	0.07
HNSC	chr10	99430571	5'UTR	novel		0.17
HNSC	chr10	99430548	Silent	novel	V6V	0.11
HNSC	chr10	99430605	5'Flank	novel		0.23
HNSC	chr10	99403567	Silent	novel	Q287Q	0.4
KIRC	chr10	99403838	Nonsense_Mutation	NA	Q227*	0.24
KIRC	chr10	99420676	Frame_Shift_Del	novel	*C83Lfs19**	0.12
KIRC	chr10	99405791	Frame_Shift_Del	novel	*P203Gfs20**	0.4
LAML	chr10	99430543	Missense_Mutation	novel	A8V	0.14
LGG	chr10	99403746	Missense_Mutation	novel	F257L	0.39
LGG	chr10	99420796	Missense_Mutation	rs377247241	T43M	0.38
LIHC	chr10	99420677	Missense_Mutation	novel	C83G	0.42
LUAD	chr10	99430608	5'Flank	novel		0.17
LUAD	chr10	99403605	Nonsense_Mutation	NA	G275*	0.36
LUAD	chr10	99397469	3'UTR	novel		0.07
LUAD	chr10	99406176	Missense_Mutation	NA	K166N	0.48
LUAD	chr10	99403838	Missense_Mutation	NA	Q227E	0.3
LUSC	chr10	99430592	5'UTR	rs745311133		0.22
LUSC	chr10	99430503	Silent	NA	L21L	0.07
OV	chr10	99406823	Frame_Shift_Ins	novel	*T110Nfs9**	0.08
OV	chr10	99420745	Missense_Mutation	novel	K60M	0.07
OV	chr10	99420734	Frame_Shift_Del	NA	*E58Tfs4**	0.23
PAAD	chr10	99420722	Missense_Mutation	novel	N68H	0.19
PAAD	chr10	99430489	Missense_Mutation	novel	R26M	0.18
PAAD	chr10	99406773	Missense_Mutation	novel	G126V	0.33
PRAD	chr10	99402660	Missense_Mutation	NA	R341Q	0.44
READ	chr10	99397629	Missense_Mutation	NA	R387Q	0.27
READ	chr10	99403514	Missense_Mutation	rs769200718	R305Q	0.17
READ	chr10	99420799	Missense_Mutation	NA	R42H	0.19
READ	chr10	99430588	5'UTR	novel		0.28
READ	chr10	99405789	Silent	rs139505253	P203P	0.19
READ	chr10	99403599	Nonsense_Mutation	novel	E277*	0.36
READ	chr10	99403829	Missense_Mutation	rs772704095	A230T	0.35
READ	chr10	99406760	Silent	NA	K130K	0.38
SKCM	chr10	99420782	Missense_Mutation	NA	P48S	0.18
SKCM	chr10	99403555	Silent	rs200430334	I291I	0.29
SKCM	chr10	99406200	Silent	novel	S158S	0.22
SKCM	chr10	99406227	Silent	rs201446452	S149S	0.49
SKCM	chr10	99403563	Missense_Mutation	NA	E289K	0.35
SKCM	chr10	99397511	3'UTR	novel		0.15
SKCM	chr10	99403743	Silent	NA	S258S	0.56
SKCM	chr10	99403744	Missense_Mutation	novel	S258F	0.57
SKCM	chr10	99403743	Silent	NA	S258S	0.38
SKCM	chr10	99406196	Missense_Mutation	rs374549839	R160C	0.31
SKCM	chr10	99402655	Missense_Mutation	NA	E343K	0.3
SKCM	chr10	99406752	Missense_Mutation	NA	P133L	0.21
STAD	chr10	99397636	Missense_Mutation	novel	S385G	0.1
STAD	chr10	99403515	Nonsense_Mutation	rs373027330	R305*	0.07
STAD	chr10	99420798	Silent	NA	R42R	0.33
STAD	chr10	99397567	Missense_Mutation	NA	A408T	0.2
STAD	chr10	99420667	Missense_Mutation	rs146802616	R86H	0.21
STAD	chr10	99397417	3'UTR	novel		0.24
STAD	chr10	99403468	Splice_Site	NA	X320_splice	0.3
STAD	chr10	99403570	Silent	NA	S286S	0.27
STAD	chr10	99397655	Silent	NA	K378K	0.23
THCA	chr10	99420683	Missense_Mutation	rs752608223	R81W	0.25
UCEC	chr10	99403550	Missense_Mutation	novel	R293Q	0.28
UCEC	chr10	99397371	3'UTR	novel		0.36
UCEC	chr10	99403769	Missense_Mutation	novel	E250K	0.37
UCEC	chr10	99397528	3'UTR	novel		0.36
UCEC	chr10	99397454	3'UTR	novel		0.37
UCEC	chr10	99406205	Missense_Mutation	novel	R157W	0.24
UCEC	chr10	99403833	Silent	NA	G228G	0.33
UCEC	chr10	99405774	Missense_Mutation	NA	Q208H	0.29
UCEC	chr10	99403829	Missense_Mutation	rs772704095	A230T	0.38
UCEC	chr10	99397597	Missense_Mutation	NA	L398I	0.18
UCEC	chr10	99420775	Missense_Mutation	NA	V50A	0.23
UCEC	chr10	99403829	Missense_Mutation	rs772704095	A230T	0.2
UCEC	chr10	99406810	Nonsense_Mutation	rs375319064	R114*	0.34
UCEC	chr10	99403628	Missense_Mutation	NA	R267K	0.35
UCEC	chr10	99397371	3'UTR	novel		0.17
UCEC	chr10	99402639	Missense_Mutation	novel	P348H	0.36
UCEC	chr10	99406809	Missense_Mutation	novel	R114Q	0.41
UCEC	chr10	99397573	Missense_Mutation	NA	H406N	0.38
UCEC	chr10	99397303	3'UTR	novel		0.6
UCEC	chr10	99406196	Missense_Mutation	rs374549839	R160C	0.06
UCEC	chr10	99406817	Silent	novel	G111G	0.55
UCEC	chr10	99397629	Missense_Mutation	NA	R387Q	0.3
UCEC	chr10	99430519	Missense_Mutation	novel	V16A	0.46
UCEC	chr10	99406760	Silent	NA	K130K	0.43
UCEC	chr10	99403829	Missense_Mutation	rs772704095	A230T	0.36
UCEC	chr10	99397614	Missense_Mutation	NA	G392D	0.26
UCEC	chr10	99420620	Splice_Region	novel		0.35
UCEC	chr10	99403528	Frame_Shift_Del	novel	*A301Pfs24**	0.58
UCEC	chr10	99406809	Missense_Mutation	novel	R114Q	0.28
UCEC	chr10	99397219	3'UTR	novel		0.33
UCEC	chr10	99420620	Splice_Region	novel		0.46
UCEC	chr10	99403528	Frame_Shift_Del	novel	*A301Pfs24**	0.48
UCEC	chr10	99403550	Missense_Mutation	novel	R293Q	0.34
UCEC	chr10	99405848	Missense_Mutation	novel	F184L	0.27
UCEC	chr10	99402660	Missense_Mutation	NA	R341Q	0.05
UCEC	chr10	99403792	Missense_Mutation	novel	R242H	0.09
UCS	chr10	99403555	Silent	rs200430334	I291I	0.61
UCS	chr10	99397660	Nonsense_Mutation	novel	E377*	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.2222	0.048655
COAD	DEL	0.1774	9.4741e-07
MESO	DEL	0.2874	0.00015289
OV	DEL	0.4041	5.3759e-12
PAAD	DEL	0.1359	0.169
READ	DEL	0.2424	0.014135
THCA	DEL	0.016	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.3036	0.1218

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.014	Kaplan-Meier Survival Analysis
ACC	0.05	Kaplan-Meier Survival Analysis
HNSC	0.048	Kaplan-Meier Survival Analysis
SKCM	0.027	Kaplan-Meier Survival Analysis
PRAD	0.044	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
CESC	0.0025	Kaplan-Meier Survival Analysis
LAML	0.00048	Kaplan-Meier Survival Analysis
LGG	0.009	Kaplan-Meier Survival Analysis
LUAD	0.0094	Kaplan-Meier Survival Analysis
UVM	0.0039	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000120053 (Gene tree)
Gene ID: 2805
Gene Symbol: GOT1
Alias: AST1
Full Name: glutamic-oxaloacetic transaminase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 34,700 bases
Position: chr10:99,396,870-99,431,569
Accession: 4432
RBP type: non-canonical RBP
Summary: Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370508	GOT1-201	2923	-	ENSP00000359539	413 (aa)	-	P17174
ENST00000471741	GOT1-202	716	-	-	- (aa)	-	-
ENST00000489349	GOT1-203	646	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000120053's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00220	Arginine biosynthesis	KEGG
hsa00250	Alanine, aspartate and glutamate metabolism	KEGG
hsa00270	Cysteine and methionine metabolism	KEGG
hsa00330	Arginine and proline metabolism	KEGG
hsa00350	Tyrosine metabolism	KEGG
hsa00360	Phenylalanine metabolism	KEGG
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01210	2-Oxocarboxylic acid metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000120053	Heart Failure	7.7333047E-004	-
ENSG00000120053	Platelet Function Tests	1.3614200E-005	-
ENSG00000120053	Dental Caries	6E-6	23064961
ENSG00000120053	Inflammatory Bowel Diseases	2E-34	28067908
ENSG00000120053	Crohn Disease	2E-20	21102463
ENSG00000120053	Inflammatory Bowel Diseases	1E-54	23128233
ENSG00000120053	Erythrocyte Indices	1E-10	23222517
ENSG00000120053	Crohn Disease	1E-36	26192919
ENSG00000120053	Hypothyroidism	1E-10	27182965
ENSG00000120053	Inflammatory Bowel Diseases	2E-63	26192919
ENSG00000120053	Crohn Disease	6E-47	26192919
ENSG00000120053	Aspartate Aminotransferases	9E-7	24124411
ENSG00000120053	Colitis, Ulcerative	2E-36	26192919
ENSG00000120053	Crohn Disease	2E-24	28067908
ENSG00000120053	Colitis, Ulcerative	2E-21	28067908

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000120053	rs76850691	10	99397681	C	Liver enzyme levels (aspartate transaminase)	24124411	[0.06-0.138] unit decrease	0.099	EFO_0004736
ENSG00000120053	rs11819158	10	99418299	?	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[6.5-9.6]	8.05	EFO_0004265\|EFO_0007908
ENSG00000120053	rs11813054	10	99420879	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000120053	rs76850691	10	99397681	C	Aspartate aminotransferase levels	30718733	[0.1-0.2] unit decrease	0.151	EFO_0004736

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000120053's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000120053	GOT1	99	53.790	WBGene00020146	got-1.2	99	53.790	Caenorhabditis_elegans
ENSG00000120053	GOT1	98	56.404	FBgn0001124	Got1	96	56.404	Drosophila_melanogaster
ENSG00000120053	GOT1	98	47.407	FBgn0001125	Got2	94	47.407	Drosophila_melanogaster
ENSG00000120053	GOT1	98	48.889	ENSG00000125166	GOT2	93	48.894	Homo_sapiens
ENSG00000120053	GOT1	98	48.642	ENSMUSG00000031672	Got2	93	48.649	Mus_musculus
ENSG00000120053	GOT1	98	46.602	YLR027C	AAT2	97	46.602	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	21873635.	IBA	Function
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	2182221.2241899.2731362.6391741.	IDA	Function
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	-	ISS	Function
GO:0004609	phosphatidylserine decarboxylase activity	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	7060339.	IDA	Component
GO:0005764	lysosome	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0006103	2-oxoglutarate metabolic process	-	ISS	Process
GO:0006107	oxaloacetate metabolic process	-	IEA	Process
GO:0006114	glycerol biosynthetic process	-	ISS	Process
GO:0006531	aspartate metabolic process	-	ISS	Process
GO:0006532	aspartate biosynthetic process	21873635.	IBA	Process
GO:0006533	aspartate catabolic process	2241899.	IDA	Process
GO:0006536	glutamate metabolic process	-	ISS	Process
GO:0007219	Notch signaling pathway	-	IEA	Process
GO:0008652	cellular amino acid biosynthetic process	-	TAS	Process
GO:0009743	response to carbohydrate	-	IEA	Process
GO:0019550	glutamate catabolic process to aspartate	-	IEA	Process
GO:0019551	glutamate catabolic process to 2-oxoglutarate	-	IEA	Process
GO:0030170	pyridoxal phosphate binding	-	IEA	Function
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	-	IEA	Process
GO:0031406	carboxylic acid binding	-	IEA	Function
GO:0032869	cellular response to insulin stimulus	8396422.	IEP	Process
GO:0032966	negative regulation of collagen biosynthetic process	-	IEA	Process
GO:0035902	response to immobilization stress	-	IEA	Process
GO:0043679	axon terminus	-	IEA	Component
GO:0046686	response to cadmium ion	-	IEA	Process
GO:0047801	L-cysteine:2-oxoglutarate aminotransferase activity	-	ISS	Function
GO:0051384	response to glucocorticoid	8396422.	IEP	Process
GO:0051481	negative regulation of cytosolic calcium ion concentration	-	IEA	Process
GO:0051902	negative regulation of mitochondrial depolarization	-	IEA	Process
GO:0055089	fatty acid homeostasis	-	IEA	Process
GO:0060290	transdifferentiation	-	IEA	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0071260	cellular response to mechanical stimulus	-	IEA	Process
GO:1990267	response to transition metal nanoparticle	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.