EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21266548Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.Proc Natl Acad Sci U S A2011 Feb 8Akutsu Mdoi: 10.1073/pnas.1015287108
16144914Estrogen-responsive finger protein as a new potential biomarker for breast cancer.Clin Cancer Res2005 Sep 1Suzuki T-
12943693Estrogen-responsive RING finger protein controls breast cancer growth.J Steroid Biochem Mol Biol2003 JunHorie K-
22452784Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP.Biochem J2012 Jun 15Dong XYdoi: 10.1042/BJ20111890.
27528750The role of Trim25 in development, disease and RNA metabolism.Biochem Soc Trans2016 Aug 15Heikel Gdoi: 10.1042/BST20160077.
26113559Overexpression of TRIM25 in Lung Cancer Regulates Tumor Cell Progression.Technol Cancer Res Treat2016 OctQin Ydoi: 10.1177/1533034615595903
27626314The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.Oncotarget2016 Oct 4Wang Sdoi: 10.18632/oncotarget.11915.
28813674An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis.Cell Rep2017 Aug 15Walsh LAdoi: 10.1016/j.celrep.2017.07.052.
29379164TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer.Oncogene2018 AprTakayama KIdoi: 10.1038/s41388-017-0095-x

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1756901474SilentnovelL344L0.09
BLCAchr17568915693'UTRnovel0.6
BLCAchr1756913937Missense_MutationNAE18K0.24
BLCAchr1756913699Missense_MutationnovelS97F0.81
BLCAchr1756891812Missense_MutationNAA594D0.47
BLCAchr1756892229Frame_Shift_InsnovelY455Lfs*40.04
BLCAchr1756904345SilentnovelQ279Q0.69
BLCAchr1756908517Missense_MutationNAG215A0.4
BLCAchr1756913812SilentNAA59A0.3
BLCAchr1756892137Missense_MutationnovelQ486E0.39
BRCAchr17568915093'UTRnovel0.4
BRCAchr1756891973Frame_Shift_DelnovelS540Rfs*600.09
BRCAchr1756901553Nonsense_MutationnovelS318*0.06
BRCAchr1756891989Missense_Mutationrs367715143R535Q0.82
BRCAchr1756913467SilentNAC174C0.55
BRCAchr1756901579Splice_SitenovelX310_splice0.09
BRCAchr1756904386Missense_MutationnovelE266Q0.09
BRCAchr1756895942Missense_MutationNAK388N0.13
CESCchr17568915993'UTRnovel0.42
CESCchr17568913293'UTRnovel0.41
CESCchr1756892095Nonsense_MutationnovelQ500*0.24
CESCchr1756891967Silentrs137888736L542L0.22
COADchr17568916383'UTRnovel0.33
COADchr1756904376Missense_MutationnovelR269M0.17
COADchr1756892123Silentrs142382736P490P0.15
COADchr1756891731Missense_MutationnovelG621D0.15
COADchr1756892016Missense_MutationNAV526A0.25
COADchr1756913526Frame_Shift_InsnovelR155Ffs*320.58
COADchr17569140045'UTRnovel0.32
COADchr1756901426Frame_Shift_DelNAS361Vfs*200.13
COADchr1756891966Missense_MutationnovelG543S0.23
COADchr1756913427Missense_Mutationrs763430514P188S0.4
COADchr1756899164Silentrs759955328H368H0.34
COADchr1756891927Missense_MutationnovelT556A0.32
COADchr1756908515Frame_Shift_Delrs746988951A216Rfs*80.11
DLBCchr1756891920Missense_MutationnovelI558N0.35
ESCAchr1756901497Missense_MutationnovelI337F0.33
GBMchr1756891820Silentrs748000227F591F0.26
GBMchr1756901449Missense_MutationnovelG353R0.2
GBMchr1756901503Missense_MutationnovelK335E0.2
GBMchr1756913547Missense_MutationnovelP148T0.34
GBMchr1756904327Missense_MutationnovelK285N0.08
HNSCchr1756913481Missense_MutationnovelE170K0.23
HNSCchr1756913563SilentnovelD142D0.4
HNSCchr17568916533'UTRnovel0.21
HNSCchr17569140395'Flanknovel0.62
HNSCchr1756908542Missense_MutationnovelT207A0.28
KICHchr1756908518Missense_Mutationrs777785843G215R0.47
KIRCchr1756908489Missense_MutationNAR224S0.25
KIRPchr1756891765Missense_MutationNAA610P0.6
LIHCchr17569139995'UTRnovel0.44
LIHCchr1756904402SilentnovelT260T0.26
LIHCchr1756904453Missense_MutationnovelQ243H0.35
LUADchr1756891939Nonsense_MutationnovelE552*0.1
LUADchr1756901562Missense_MutationNAR315L0.4
LUADchr1756891980Missense_MutationNAP538L0.27
LUADchr1756913636Missense_MutationnovelT118K0.23
LUADchr1756904365Nonsense_MutationnovelK273*0.25
LUSCchr1756913428SilentnovelS187S0.08
LUSCchr1756891866Missense_MutationNAR576P0.48
LUSCchr1756891936Missense_MutationNAW553R0.18
LUSCchr1756913500SilentnovelL163L0.6
LUSCchr17568916763'UTRnovel0.42
LUSCchr1756904302Nonsense_MutationnovelE294*0.18
LUSCchr1756908555SilentnovelL202L0.2
MESOchr1756899155SilentnovelA371A0.18
OVchr1756908482Missense_MutationnovelQ227K0.12
OVchr17568879743'UTRnovel1
OVchr1756895599Missense_MutationnovelV396F0.05
OVchr17568916983'UTRnovel0.1
PRADchr1756891961SilentNAR544R0.27
PRADchr1756891872Missense_MutationnovelA574V0.42
PRADchr1756892182Missense_MutationnovelA471T0.38
READchr1756892144Missense_MutationNAE483D0.36
READchr1756904266Missense_Mutationrs747508258E306K0.49
SARCchr17568916413'UTRnovel0.88
SKCMchr1756913615Missense_MutationnovelS125F0.34
SKCMchr1756901467Missense_Mutationrs772478621E347K0.23
SKCMchr1756891823SilentnovelF590F0.29
SKCMchr1756904302Missense_MutationNAE294K0.31
SKCMchr1756891950Missense_MutationnovelS548F0.09
SKCMchr1756891802SilentNAV597V0.28
SKCMchr1756891756Missense_MutationNAP613S0.21
STADchr1756895526Missense_MutationNAL420S0.22
STADchr1756892063Frame_Shift_DelnovelI511Sfs*160.16
STADchr1756913551SilentnovelQ146Q0.13
STADchr1756904416Nonsense_MutationNAE256*0.22
STADchr1756892126SilentNAR489R0.08
STADchr1756891745Nonsense_MutationNAW616*0.24
STADchr1756904399Silentrs766353810R261R0.17
STADchr17568916713'UTRnovel0.34
STADchr1756899135Missense_Mutationrs200203148R378H0.19
UCECchr1756895942Missense_MutationNAK388N0.34
UCECchr1756904325Missense_MutationNAS286N0.27
UCECchr1756892198Silentrs770136591T465T0.18
UCECchr1756895372Missense_Mutationrs766569547L445P0.44
UCECchr1756892197Missense_Mutationrs141649169A466T0.11
UCECchr17568908643'UTRnovel0.15
UCECchr1756895413Silentrs756570736P431P0.08
UCECchr17568910133'UTRnovel0.67
UCECchr1756892133Missense_MutationnovelN487T0.28
UCECchr1756891963Missense_Mutationrs762576334R544C0.32
UCECchr17568913833'UTRnovel0.6
UCECchr1756895413Silentrs756570736P431P0.2
UCECchr1756892197Missense_MutationnovelA466S0.44
UCECchr1756895520Splice_Siters752704891X422_splice0.27
UCECchr1756908514Missense_Mutationrs769575690A216V0.34
UCECchr17568912793'UTRnovel0.43
UCECchr1756904355Missense_MutationnovelT276I0.05
UCECchr1756908506Missense_MutationNAA219S0.37
UCECchr1756904341Missense_MutationNAL281I0.26
UCECchr1756913910Missense_MutationnovelP27T0.27
UCECchr1756895411Missense_MutationnovelN432S0.35
UCECchr1756901479Missense_MutationnovelD343Y0.18
UCECchr1756908552SilentNAR203R0.24
UCECchr1756891869Missense_Mutationrs764739358T575M0.45
UCECchr1756901531Silentrs755954951P325P0.31
UCECchr1756908519Silentrs749229572N214N0.39
UCECchr1756891941Missense_MutationnovelV551A0.38
UCSchr1756901508Missense_MutationnovelL333P0.29

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.04170.18166
KIRPAMP0.66320.14801
READAMP0.16970.15915
THCADEL0.0020.221
UVMAMP0.16250.054583

Survival Analysis
CancerP-value Q-value
STAD0.00047

Kaplan-Meier Survival Analysis

HNSC0.042

Kaplan-Meier Survival Analysis

SKCM0.035

Kaplan-Meier Survival Analysis

BRCA0.012

Kaplan-Meier Survival Analysis

COAD0.036

Kaplan-Meier Survival Analysis

PAAD0.0052

Kaplan-Meier Survival Analysis

BLCA0.037

Kaplan-Meier Survival Analysis

CESC0.0064

Kaplan-Meier Survival Analysis

READ0.0061

Kaplan-Meier Survival Analysis

LAML0.038

Kaplan-Meier Survival Analysis

KICH0.0062

Kaplan-Meier Survival Analysis

LIHC0.004

Kaplan-Meier Survival Analysis

DLBC0.033

Kaplan-Meier Survival Analysis

LGG0.0018

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000121060 (Gene tree)
Gene ID
7706
Gene Symbol
TRIM25
Alias
EFP|RNF147|ZNF147
Full Name
tripartite motif containing 25
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
77,694 bases
Position
chr17:56,836,387-56,914,080
Accession
12932
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
29117863RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.BMC Biol2017 Nov 8Choudhury NRdoi: 10.1186/s12915-017-0444-9.
30342007TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense.J Mol Biol2018 Dec 7Sanchez JGdoi: 10.1016/j.jmb.2018.10.003
31289203Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy.Haematologica2019 Jul 9Tong Jdoi: 10.3324/haematol.2019.218289
23950712A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.PLoS Pathog2013Oshiumi Hdoi: 10.1371/journal.ppat.1003533
27122586Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.J Virol2016 Jun 24Jiang Jdoi: 10.1128/JVI.00549-16
29107643Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.Cell Host Microbe2017 Nov 8Meyerson NRdoi: 10.1016/j.chom.2017.10.003
30797711Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation.EBioMedicine2019 MarWang Zdoi: 10.1016/j.ebiom.2018.12.061
26687707Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity.Cell Microbiol2016 JunKathum OAdoi: 10.1111/cmi.12559
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000572550TRIM25-206519--- (aa)--
ENST00000570473TRIM25-203498--- (aa)--
ENST00000572021TRIM25-2051555-ENSP0000045998043 (aa)-I3L2W4
ENST00000537230TRIM25-2022906-ENSP00000445961630 (aa)-Q14258
ENST00000316881TRIM25-2015734-ENSP00000323889630 (aa)-Q14258
ENST00000570749TRIM25-204614--- (aa)--
ENST00000574997TRIM25-209440--- (aa)--
ENST00000573108TRIM25-207952--- (aa)--
ENST00000574234TRIM25-208471--- (aa)--
ENST00000648772TRIM25-2104248-ENSP00000498158456 (aa)--
Gene Model
Click here to download ENSG00000121060's gene model file
Pathways
Pathway IDPathway NameSource
hsa04064NF-kappa B signaling pathwayKEGG
hsa04622RIG-I-like receptor signaling pathwayKEGG
hsa05164Influenza AKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000121060rs284886431756880732TMyopia (age of diagnosis)29808027[1.08-1.6] unit decrease1.3391EFO_0004847|HP_0000545
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000121060's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000121060TRIM259973.386ENSMUSG00000000275Trim259973.071Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding19454348.20818395.22452784.24478431.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006511ubiquitin-dependent protein catabolic process22452784.24810856.IMPProcess
GO:0006513protein monoubiquitination24810856.IMPProcess
GO:0008270zinc ion binding-IEAFunction
GO:0016032viral process-IEAProcess
GO:0016604nuclear body-IDAComponent
GO:0016874ligase activity-IEAFunction
GO:0019985translesion synthesis-TASProcess
GO:0030433ubiquitin-dependent ERAD pathway24810856.IMPProcess
GO:0032480negative regulation of type I interferon production-TASProcess
GO:0033280response to vitamin D-IEAProcess
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling23077300.IDAProcess
GO:0043627response to estrogen22452784.IDAProcess
GO:0045087innate immune response18248090.IDAProcess
GO:0045087innate immune response-TASProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0046596regulation of viral entry into host cell18248090.IDAProcess
GO:0046597negative regulation of viral entry into host cell-IEAProcess
GO:0051091positive regulation of DNA-binding transcription factor activity23077300.IMPProcess
GO:0051092positive regulation of NF-kappaB transcription factor activity23077300.IMPProcess
GO:0051607defense response to virus-IEAProcess
GO:0060333interferon-gamma-mediated signaling pathway-TASProcess
GO:0061630ubiquitin protein ligase activity24810856.IMPFunction
GO:1902186regulation of viral release from host cell18248090.IMPProcess
GO:1902187negative regulation of viral release from host cell-IEAProcess
GO:1990830cellular response to leukemia inhibitory factor-IEAProcess
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