EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	96351954	Missense_Mutation	novel	T282S	0.13
BLCA	chr2	96360602	Silent	novel	L493L	0.08
BLCA	chr2	96351964	Missense_Mutation	rs561791494	T285M	0.21
BLCA	chr2	96360626	Silent	novel	Q501Q	0.08
BLCA	chr2	96341754	Silent	novel	L44L	0.2
BLCA	chr2	96369431	Silent	NA	P699P	0.34
BLCA	chr2	96341604	Intron	novel		0.33
BLCA	chr2	96354236	Silent	novel	I352I	0.12
BRCA	chr2	96353394	Splice_Site	novel	X334_splice	0.1
BRCA	chr2	96341687	Frame_Shift_Ins	NA	*H24Pfs36**	0.54
BRCA	chr2	96353354	Missense_Mutation	NA	A320G	0.26
BRCA	chr2	96360175	Missense_Mutation	NA	K464E	0.15
BRCA	chr2	96369495	Missense_Mutation	NA	E721K	0.15
BRCA	chr2	96353381	Missense_Mutation	NA	S329N	0.12
BRCA	chr2	96373488	3'UTR	novel		0.07
BRCA	chr2	96359078	Silent	novel	I414I	0.06
BRCA	chr2	96360145	Missense_Mutation	NA	D454Y	0.45
CESC	chr2	96341823	Silent	novel	R67R	0.21
CESC	chr2	96364493	Missense_Mutation	novel	A534T	0.43
CESC	chr2	96369038	Missense_Mutation	rs141849409	G689R	0.4
CESC	chr2	96354231	Missense_Mutation	NA	D351H	0.49
COAD	chr2	96341699	Missense_Mutation	NA	A26V	0.33
COAD	chr2	96373403	3'UTR	rs374913489		0.08
COAD	chr2	96344220	Silent	NA	R237R	0.4
COAD	chr2	96367273	Missense_Mutation	NA	I633T	0.41
COAD	chr2	96360183	Frame_Shift_Del	NA	*D469Ifs25**	0.25
COAD	chr2	96359067	Missense_Mutation	novel	D411N	0.42
COAD	chr2	96344216	Missense_Mutation	rs752350518	D236G	0.43
COAD	chr2	96359296	Intron	novel		0.25
COAD	chr2	96344142	Silent	NA	A211A	0.33
COAD	chr2	96366001	Silent	novel	A608A	0.1
COAD	chr2	96368969	Splice_Region	novel		0.41
COAD	chr2	96369000	Missense_Mutation	rs774780229	A676V	0.36
COAD	chr2	96373598	3'UTR	novel		0.57
COAD	chr2	96369019	Silent	NA	A682A	0.15
COAD	chr2	96360606	Missense_Mutation	NA	K495E	0.29
COAD	chr2	96360190	Missense_Mutation	NA	D469N	0.22
COAD	chr2	96364562	Missense_Mutation	novel	D557N	0.23
COAD	chr2	96341783	Missense_Mutation	NA	D54A	0.13
COAD	chr2	96365884	Silent	NA	D569D	0.3
ESCA	chr2	96343174	Silent	novel	A155A	0.43
ESCA	chr2	96373650	3'UTR	novel		0.07
GBM	chr2	96369444	Missense_Mutation	NA	Q704K	0.13
GBM	chr2	96341578	Intron	novel		0.26
GBM	chr2	96360628	Missense_Mutation	novel	N502T	0.04
GBM	chr2	96354183	Missense_Mutation	novel	S335P	0.17
GBM	chr2	96359229	Intron	novel		0.12
GBM	chr2	96341748	Silent	rs139287054	A42A	0.2
HNSC	chr2	96360230	Missense_Mutation	novel	V482A	0.27
HNSC	chr2	96342831	Missense_Mutation	novel	E147Q	0.29
HNSC	chr2	96359071	Missense_Mutation	novel	G412V	0.14
HNSC	chr2	96353338	Missense_Mutation	novel	I315F	0.31
HNSC	chr2	96359044	Splice_Site	novel	X403_splice	0.25
HNSC	chr2	96341779	Missense_Mutation	novel	E53K	0.17
KICH	chr2	96367257	Missense_Mutation	novel	V628L	0.59
KICH	chr2	96368975	Missense_Mutation	novel	N668D	0.11
KIRC	chr2	96359054	Missense_Mutation	NA	M406I	0.37
KIRC	chr2	96359163	Missense_Mutation	NA	D443H	0.27
LAML	chr2	96341668	Missense_Mutation	novel	S16P	0.07
LAML	chr2	96369492	Missense_Mutation	novel	N720H	0.13
LGG	chr2	96344141	Missense_Mutation	novel	A211D	0.24
LIHC	chr2	96351900	Missense_Mutation	NA	T264A	0.24
LIHC	chr2	96373405	3'UTR	novel		0.25
LUAD	chr2	96364493	Missense_Mutation	rs201839137	A534S	0.15
LUAD	chr2	96351984	Frame_Shift_Del	novel	*P292Qfs3**	0.09
LUAD	chr2	96342059	Missense_Mutation	NA	D94E	0.06
LUAD	chr2	96365980	Missense_Mutation	NA	Q601H	0.15
LUAD	chr2	96341500	Intron	novel		0.19
LUAD	chr2	96365966	Missense_Mutation	rs140487512	K597E	0.04
LUAD	chr2	96366005	Missense_Mutation	novel	G610R	0.1
LUAD	chr2	96341638	Splice_Region	rs757408775		0.24
LUAD	chr2	96342847	Missense_Mutation	NA	K152R	0.1
LUAD	chr2	96373408	3'UTR	novel		0.35
LUAD	chr2	96359105	Missense_Mutation	novel	M423I	0.17
LUAD	chr2	96343174	Silent	novel	A155A	0.25
LUAD	chr2	96353356	Missense_Mutation	NA	G321W	0.09
LUAD	chr2	96359072	Silent	novel	G412G	0.17
LUAD	chr2	96366053	Nonsense_Mutation	NA	Q626*	0.2
LUSC	chr2	96353376	Missense_Mutation	novel	W327C	0.14
LUSC	chr2	96359140	Missense_Mutation	novel	T435I	0.27
LUSC	chr2	96341748	Silent	rs139287054	A42A	0.26
LUSC	chr2	96359164	Missense_Mutation	novel	D443A	0.17
LUSC	chr2	96353340	Missense_Mutation	rs770262566	I315M	0.17
LUSC	chr2	96354290	Silent	novel	G370G	0.52
LUSC	chr2	96364497	Missense_Mutation	novel	Q535L	0.38
MESO	chr2	96359268	Intron	novel		0.39
OV	chr2	96369480	Silent	rs147238606	L716L	0.33
OV	chr2	96341858	Missense_Mutation	novel	T79N	0.07
OV	chr2	96342053	Silent	novel	S92S	0.09
PAAD	chr2	96367340	Silent	novel	L655L	0.05
PAAD	chr2	96341822	Missense_Mutation	rs769563241	R67Q	0.23
PAAD	chr2	96341880	Silent	novel	A86A	0.16
PAAD	chr2	96344153	Missense_Mutation	novel	K215T	0.21
PAAD	chr2	96360595	Missense_Mutation	novel	T491I	0.25
PAAD	chr2	96354258	Missense_Mutation	novel	D360Y	0.12
PRAD	chr2	96354231	Missense_Mutation	NA	D351Y	0.28
READ	chr2	96354191	Silent	rs530283845	S337S	0.36
SARC	chr2	96354311	Missense_Mutation	novel	D377E	0.15
SKCM	chr2	96373366	3'UTR	novel		0.13
SKCM	chr2	96367275	Missense_Mutation	NA	H634Y	0.28
SKCM	chr2	96373496	3'UTR	novel		0.67
SKCM	chr2	96344215	Missense_Mutation	NA	D236Y	0.43
SKCM	chr2	96351977	Silent	rs773957779	L289L	0.09
SKCM	chr2	96359281	Intron	novel		0.19
SKCM	chr2	96341770	Missense_Mutation	NA	P50S	0.29
SKCM	chr2	96359060	Silent	novel	S408S	0.48
SKCM	chr2	96359061	Missense_Mutation	novel	L409F	0.47
SKCM	chr2	96364551	Missense_Mutation	rs766296287	N553S	0.23
SKCM	chr2	96342113	Silent	NA	S112S	0.45
STAD	chr2	96373434	3'UTR	novel		0.24
STAD	chr2	96354251	Silent	rs771154917	D357D	0.22
STAD	chr2	96360183	Frame_Shift_Del	NA	*D469Ifs25**	0.18
STAD	chr2	96360182	Frame_Shift_Ins	novel	*D469Rfs3**	0.18
STAD	chr2	96341743	Missense_Mutation	novel	K41Q	0.32
STAD	chr2	96359089	Missense_Mutation	novel	C418Y	0.29
STAD	chr2	96341870	Missense_Mutation	rs759878969	R83H	0.41
STAD	chr2	96359162	Silent	rs148820630	P442P	0.13
STAD	chr2	96365993	Missense_Mutation	novel	P606S	0.27
STAD	chr2	96354320	Missense_Mutation	NA	D380E	0.09
STAD	chr2	96365922	Missense_Mutation	NA	P582L	0.22
STAD	chr2	96360183	Frame_Shift_Del	NA	*D469Ifs25**	0.33
STAD	chr2	96343250	Frame_Shift_Del	novel	*L183Wfs11**	0.23
STAD	chr2	96359064	Frame_Shift_Del	novel	*D411Mfs13**	0.36
STAD	chr2	96360183	Frame_Shift_Del	NA	*D469Ifs25**	0.19
STAD	chr2	96341479	Intron	novel		0.23
STAD	chr2	96359188	Missense_Mutation	rs778708976	R451H	0.11
STAD	chr2	96353323	Missense_Mutation	novel	A310T	0.43
THYM	chr2	96373462	3'UTR	novel		0.63
THYM	chr2	96364591	Missense_Mutation	novel	Q566H	0.08
UCEC	chr2	96359115	Nonsense_Mutation	NA	E427*	0.32
UCEC	chr2	96354382	Missense_Mutation	novel	S401N	0.37
UCEC	chr2	96359051	Silent	novel	E405E	0.42
UCEC	chr2	96364529	Nonsense_Mutation	novel	E546*	0.34
UCEC	chr2	96373791	3'UTR	novel		0.44
UCEC	chr2	96354327	Missense_Mutation	rs775388261	A383T	0.24
UCEC	chr2	96373453	3'UTR	novel		0.6
UCEC	chr2	96341748	Silent	rs139287054	A42A	0.39
UCEC	chr2	96354376	Missense_Mutation	novel	V399A	0.36
UCEC	chr2	96359199	Splice_Region	novel		0.3
UCEC	chr2	96367297	Missense_Mutation	NA	K641T	0.1
UCEC	chr2	96354308	Silent	rs748559519	N376N	0.19
UCEC	chr2	96353331	Missense_Mutation	NA	D312E	0.43
UCEC	chr2	96343211	Missense_Mutation	novel	R168C	0.08
UCEC	chr2	96373745	3'UTR	novel		0.2
UCEC	chr2	96344229	Missense_Mutation	NA	E240D	0.54
UCEC	chr2	96353353	Missense_Mutation	novel	A320T	0.41
UCEC	chr2	96373642	3'UTR	rs556121483		0.17
UCEC	chr2	96343273	Silent	rs577284139	P188P	0.27
UCEC	chr2	96373420	3'UTR	novel		0.27
UCEC	chr2	96359185	Missense_Mutation	rs376237191	R450Q	0.57
UCEC	chr2	96341633	Intron	novel		0.42
UCEC	chr2	96351922	Missense_Mutation	novel	R271I	0.13
UCEC	chr2	96359179	Missense_Mutation	NA	R448M	0.41
UCEC	chr2	96343177	Silent	novel	G156G	0.24
UCEC	chr2	96365974	Silent	novel	A599A	0.34
UCEC	chr2	96341636	Splice_Region	novel		0.33
UCEC	chr2	96373822	3'UTR	novel		0.25
UCEC	chr2	96342052	Missense_Mutation	rs757817973	S92I	0.38
UCEC	chr2	96373507	3'UTR	novel		0.36
UCEC	chr2	96344171	Missense_Mutation	novel	R221I	0.24
UCEC	chr2	96364574	Missense_Mutation	novel	F561V	0.44
UCEC	chr2	96373350	Nonstop_Mutation	novel	742Lext60	0.15
UCEC	chr2	96360183	Frame_Shift_Del	NA	*D469Ifs25**	0.44
UCEC	chr2	96342831	Missense_Mutation	rs745604508	E147K	0.34
UCEC	chr2	96373323	Missense_Mutation	novel	S733Y	0.21
UCEC	chr2	96343223	Missense_Mutation	rs543345745	V172I	0.35
UCEC	chr2	96341866	Missense_Mutation	novel	P82S	0.27
UCEC	chr2	96351896	Silent	novel	L262L	0.32
UCEC	chr2	96354190	Missense_Mutation	rs750951986	S337L	0.31
UCEC	chr2	96373420	3'UTR	novel		0.45
UCEC	chr2	96341842	Missense_Mutation	NA	D74Y	0.4
UCEC	chr2	96367333	Frame_Shift_Del	novel	*S653Tfs30**	0.1
UCEC	chr2	96373524	3'UTR	rs189162735		0.36
UCEC	chr2	96343222	Silent	rs776797054	A171A	0.25
UCEC	chr2	96364492	Missense_Mutation	novel	M533I	0.44
UCEC	chr2	96373802	3'UTR	novel		0.46
UCEC	chr2	96343231	Silent	rs147327251	A174A	0.27
UCEC	chr2	96366005	Nonsense_Mutation	NA	G610*	0.33
UCEC	chr2	96354327	Missense_Mutation	rs775388261	A383T	0.39
UCEC	chr2	96364499	Missense_Mutation	novel	G536S	0.25
UCEC	chr2	96353307	Splice_Region	novel	A304A	0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0139	0.08832
PAAD	DEL	0.0326	0.2014
SARC	AMP	0.1751	0.15096

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0055	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.00016	Kaplan-Meier Survival Analysis
MESO	0.00022	Kaplan-Meier Survival Analysis
SKCM	0.024	Kaplan-Meier Survival Analysis
PRAD	0.035	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0003	Kaplan-Meier Survival Analysis
PCPG	0.035	Kaplan-Meier Survival Analysis
READ	0.037	Kaplan-Meier Survival Analysis
KICH	0.0012	Kaplan-Meier Survival Analysis
UCEC	0.00082	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00039	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000121152 (Gene tree)
Gene ID: 23397
Gene Symbol: NCAPH
Alias: CAP-H|hCAP-H|BRRN1
Full Name: non-SMC condensin I complex subunit H
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 41,355 bases
Position: chr2:96,335,741-96,377,095
Accession: 1112
RBP type: non-canonical RBP
Summary: This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000455200	NCAPH-205	2952	-	ENSP00000407308	730 (aa)	-	E9PHA2
ENST00000435349	NCAPH-203	779	-	ENSP00000415162	182 (aa)	-	H7C415
ENST00000240423	NCAPH-201	2763	XM_005263908	ENSP00000240423	741 (aa)	XP_005263965	Q15003
ENST00000477409	NCAPH-207	1573	-	-	- (aa)	-	-
ENST00000427946	NCAPH-202	2363	-	ENSP00000400774	605 (aa)	-	Q15003
ENST00000435975	NCAPH-204	1852	-	ENSP00000405237	607 (aa)	-	C9J470
ENST00000456906	NCAPH-206	673	-	ENSP00000401227	216 (aa)	-	C9JZP1

Gene Model

Click here to download ENSG00000121152's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000121152	Platelet Function Tests	1.0500000E-008	-
ENSG00000121152	Platelet Function Tests	9.2100000E-009	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000121152's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000796	condensin complex	11136719.	IDA	Component
GO:0000799	nuclear condensin complex	21873635.	IBA	Component
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0005515	protein binding	17268547.21633354.21730191.26496610.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007076	mitotic chromosome condensation	21873635.	IBA	Process
GO:0007076	mitotic chromosome condensation	11136719.11694586.	IDA	Process
GO:0007076	mitotic chromosome condensation	27737959.	IMP	Process
GO:0010032	meiotic chromosome condensation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0044547	DNA topoisomerase binding	21873635.	IBA	Function
GO:0051301	cell division	-	IEA	Process
GO:0051309	female meiosis chromosome separation	-	IEA	Process
GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	21873635.	IBA	Function
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.