EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26438629The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs.J Mol Histol2015 DecZhang Tdoi: 10.1007/s10735-015-9639-y
27365047Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor.Nucleic Acids Res2016 Oct 14Li N-
25944080Utility of SAM68 in the progression and prognosis for bladder cancer.BMC Cancer2015 May 6Zhang Zdoi: 10.1186/s12885-015-1367-x.
23937454High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer.BMC Gastroenterol2013 Aug 9Liao WTdoi: 10.1186/1471-230X-13-126.
21700735Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer.Ann Oncol2012 MarLi Zdoi: 10.1093/annonc/mdr290
26273626SAM68: Signal Transduction and RNA Metabolism in Human Cancer.Biomed Res Int2015Frisone Pdoi: 10.1155/2015/528954
20028857Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68.Cancer Res2010 Jan 1Paronetto MPdoi: 10.1158/0008-5472.CAN-09-2788
21642356Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer.Carcinogenesis2011 OctChen ZYdoi: 10.1093/carcin/bgr088
27623016Sam68 is Overexpressed in Epithelial Ovarian Cancer and Promotes Tumor Cell Proliferation.Med Sci Monit2016 Sep 13Dong L-
30064438The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68.Mol Cancer2018 Jul 31Wang Xdoi: 10.1186/s12943-018-0860-7.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr132039559Missense_MutationNAS407F0.2
BLCAchr132037921Missense_MutationnovelR331Q0.34
BLCAchr132033191Missense_MutationnovelE210K0.31KH_1
BLCAchr132037962Missense_MutationNAP345A0.08
BLCAchr1320139735'UTRnovel0.64
BLCAchr132036960Missense_MutationNAL274F0.12
BLCAchr132042599Missense_MutationNAR436T0.3
BLCAchr132033333Missense_MutationnovelP257L0.12
BLCAchr132037956Missense_MutationnovelP343A0.12
BLCAchr132033210Missense_MutationnovelG216V0.29
BLCAchr132033326Missense_MutationnovelL255V0.31
BRCAchr132030398SilentNAL161L0.13
BRCAchr132036978SilentnovelP280P0.1
BRCAchr132036909Splice_SiteNAX258_splice0.17
CESCchr1320429463'UTRnovel0.38
CESCchr1320435723'UTRnovel0.3
CESCchr132038569Silentrs751047839Y375Y0.25
CESCchr1320434733'UTRnovel0.09
CESCchr1320434743'UTRnovel0.09
CESCchr132036983Missense_MutationnovelR282H0.25
CESCchr1320430063'UTRnovel0.21
CHOLchr1320428813'UTRnovel0.11
COADchr1320426443'UTRnovel0.38
COADchr132037857Frame_Shift_InsNAA312Gfs*560.28
COADchr132031554Missense_MutationNAQ180K0.28KH_1
COADchr132033200Missense_MutationnovelR213C0.38KH_1
COADchr132014303Missense_MutationnovelY103C0.23
COADchr132033269Frame_Shift_DelnovelP237Hfs*190.32
COADchr132038035Missense_MutationNAY369C0.28
COADchr132014256Frame_Shift_InsnovelS90Lfs*410.4
COADchr132037932Frame_Shift_DelNAP336Hfs*40.41
ESCAchr1320430053'UTRnovel0.16
ESCAchr1320437523'UTRrs5557168490.15
ESCAchr1320427583'UTRnovel0.58
ESCAchr1320429673'UTRnovel0.5
HNSCchr132037971Missense_MutationnovelR348W0.13
HNSCchr132033291Frame_Shift_DelnovelM244Wfs*120.27
KIRCchr132038612Missense_MutationNAS390C0.19
KIRPchr132042611Missense_MutationNAY440C0.24
LAMLchr132037935Frame_Shift_InsnovelP337Hfs*40.12
LUADchr132037841SilentNAR304R0.51
LUADchr132037903Missense_MutationnovelR325K0.19
LUADchr132038596Missense_MutationnovelE384D0.33
LUADchr132031584Missense_MutationNAE190Q0.07KH_1
LUADchr132038010Missense_MutationNAP361T0.13
LUSCchr132038583Missense_MutationnovelY380C0.26
LUSCchr132039516Missense_MutationnovelD393N0.19
LUSCchr132036996SilentnovelV286V0.33
LUSCchr132036934Missense_MutationNAE266Q0.2
LUSCchr132038601Missense_MutationNAY386C0.07
LUSCchr1320426713'UTRnovel0.4
MESOchr1320139705'UTRnovel0.44
OVchr132033249Missense_MutationnovelV229G0.09
OVchr132036967Missense_MutationNAV277L0.06
OVchr132038594Missense_Mutationrs777529270E384K0.42
OVchr132037857Frame_Shift_InsNAA312Gfs*560.06
READchr132037858Frame_Shift_DelNAA312Lfs*80.23
SARCchr132037957Missense_MutationnovelP343L0.08
SKCMchr132033225Missense_MutationNAA221V0.4
SKCMchr132037906Missense_MutationNAG326V0.31
SKCMchr132030396SilentNAL161L0.39
SKCMchr132036959Missense_MutationNAL274W0.16
SKCMchr132033187Splice_SiteNAX209_splice0.39
SKCMchr132014248Missense_MutationnovelP85S0.14
SKCMchr132014249Missense_MutationnovelP85L0.15
SKCMchr132037039Missense_MutationNAP301S0.37
SKCMchr132037039Missense_MutationNAP301S0.23
SKCMchr132030417Missense_MutationnovelP168S0.43KH_1
STADchr132042617Missense_MutationNAR442H0.16
STADchr132037848Nonsense_MutationNAG307*0.12
STADchr132036913Missense_MutationNAM259V0.1
UCECchr132033319Missense_MutationNAK252N0.39
UCECchr1320435273'UTRnovel0.33
UCECchr1320436243'UTRrs7631889760.36
UCECchr1320432833'UTRnovel0.6
UCECchr132037979Silentrs373128165A350A0.16
UCECchr132030344Missense_MutationNAE143D0.21
UCECchr132042558Silentrs780046000S422S0.23
UCECchr132030326Frame_Shift_DelnovelK139Rfs*160.07
UCECchr132042560Missense_MutationNAL423P0.42
UCECchr1320432913'UTRnovel0.27
UCECchr1320426743'UTRnovel0.38
UCECchr132033323Missense_MutationnovelF254V0.38
UCECchr1320431703'UTRnovel0.42
UCECchr1320438483'UTRnovel0.31
UCECchr132036989Missense_Mutationrs375097901R284H0.3
UCECchr1320428793'UTRnovel0.43
UCECchr1320432833'UTRnovel0.94
UCECchr1320432833'UTRnovel0.52
UCECchr1320430193'UTRnovel0.12
UCECchr1320437773'UTRnovel0.39
UCECchr1320432833'UTRnovel0.44
UCECchr132031568Missense_MutationNAI184M0.16KH_1
UCECchr132036917Missense_MutationnovelM260T0.38
UCECchr132037859SilentNAR310R0.25
UCECchr132038593Silentrs755833134Y383Y0.16
UCECchr132042558Silentrs780046000S422S0.36
UCECchr1320432833'UTRnovel0.56
UCECchr1320432833'UTRnovel0.5
UCECchr132031545Missense_MutationNAL177I0.24KH_1
UCECchr1320437453'UTRnovel0.36
UCECchr132037978Missense_MutationnovelA350V0.28
UCECchr132039536SilentnovelY399Y0.33
UCECchr132037838SilentnovelG303G0.5

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.1250.011841
LIHCDEL0.33241.6679e-20
TGCTDEL0.140.00046313

Survival Analysis
CancerP-value Q-value
THYM0.00073

Kaplan-Meier Survival Analysis

KIRC0.00011

Kaplan-Meier Survival Analysis

SARC0.00033

Kaplan-Meier Survival Analysis

ACC0.00024

Kaplan-Meier Survival Analysis

KIRP0.0095

Kaplan-Meier Survival Analysis

COAD0.033

Kaplan-Meier Survival Analysis

PAAD0.023

Kaplan-Meier Survival Analysis

READ0.037

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LGG0.0036

Kaplan-Meier Survival Analysis

LUAD0.01

Kaplan-Meier Survival Analysis

UVM0.02

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000121774 (Gene tree)
Gene ID
10657
Gene Symbol
KHDRBS1
Alias
Sam68|p62|FLJ34027
Full Name
KH RNA binding domain containing, signal transduction associated 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
47,166 bases
Position
chr1:32,013,694-32,060,859
Accession
18116
RBP type
canonical RBP
Summary
This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000313829KH_1PF00013.292.7e-1011
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27235792Sam68 modulates apoptosis of intestinal epithelial cells via mediating NF-kB activation in ulcerative colitis.Mol Immunol2016 JulQian Jdoi: 10.1016/j.molimm.2016.05.011
29785588Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF-kB/P65 Pathway in Rheumatoid Arthritis.Inflammation2018 OctSun Wdoi: 10.1007/s10753-018-0809-4.
11395494Identification of Sam68 arginine glycine-rich sequences capable of conferring nonspecific RNA binding to the GSG domain.J Biol Chem2001 Aug 17Chen T-
15471878The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.J Biol Chem2004 Dec 24Haegebarth A-
15021911The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity.Oncogene2004 May 6Babic I-
17764653Arginine methylation of Sam68 and SLM proteins negatively regulates their poly(U) RNA binding activity.Arch Biochem Biophys2007 Oct 1Rho J-
17726370Regulation of arginine methylation in endothelial cells: role in premature senescence and apoptosis.Cell Cycle2007 Oct 15Polotskaia A-
23637638The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain.PLoS Genet2013 AprEhrmann Idoi: 10.1371/journal.pgen.1003474
30589479A Sam68-dependent alternative splicing program shapes postsynaptic protein complexes.Eur J Neurosci2019 JunWitte Hdoi: 10.1111/ejn.14332
19609631Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons.Neurotox Res2010 FebCasafont Idoi: 10.1007/s12640-009-9086-1
12823272Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action.Clin Exp Immunol2003 JulSanchez-Margalet V-
12496368Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68.Mol Cancer Res2002 NovHong W-
12490714Identification of cellular mRNA targets for RNA-binding protein Sam68.Nucleic Acids Res2002 Dec 15Itoh M-
12163178Retardation of the G2-M phase progression on gene disruption of RNA binding protein Sam68 in the DT40 cell line.FEBS Lett2002 Aug 14Li QH-
16362077Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss.PLoS Genet2005 DecRichard S-
16221888The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes.Mol Biol Cell2006 JanParonetto MP-
15843054Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads.Neurosci Lett2005 May 13Belly A-
15619005Role of Sam68 as an adaptor protein in signal transduction.Cell Mol Life Sci2005 JanNajib S-
14736338Sam68 exerts separable effects on cell cycle progression and apoptosis.BMC Cell Biol2004 Jan 22Taylor SJ-
14643926Sam68, the KH domain-containing superSTAR.Biochim Biophys Acta2003 Dec 5Lukong KE-
20186122Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients.EMBO J2010 Apr 7Sellier Cdoi: 10.1038/emboj.2010.21
19912651Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies.BMC Cell Biol2009 Nov 13Rajan Pdoi: 10.1186/1471-2121-10-82.
19875495Sam68: a new STAR in the male fertility firmament.J Androl2010 Jan-FebSette Cdoi: 10.2164/jandrol.109.008136
19457263The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs.BMC Mol Biol2009 May 20Galarneau Adoi: 10.1186/1471-2199-10-47.
19380878Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis.J Cell Biol2009 Apr 20Paronetto MPdoi: 10.1083/jcb.200811138.
18936165Sam68 regulates a set of alternatively spliced exons during neurogenesis.Mol Cell Biol2009 JanChawla Gdoi: 10.1128/MCB.01349-08
18481990Regulation of gene expression by the RNA-binding protein Sam68 in cancer.Biochem Soc Trans2008 JunRajan Pdoi: 10.1042/BST0360505.
17621265Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis.Oncogene2008 Jan 17Richard S-
17179751mRNAs associated with the Sam68 RNA binding protein.RNA Biol2006 AprTremblay GA-
16996007Effect of proline rich domain of an RNA-binding protein Sam68 in cell growth process, death and B cell signal transduction.Chin Med J (Engl)2006 Sep 20Li QH-
22196734SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.Cell2011 Dec 23Iijima Tdoi: 10.1016/j.cell.2011.11.028.
22005517Sam68 interacts with IRS1.Biochem Pharmacol2012 Jan 1Quintana-Portillo Rdoi: 10.1016/j.bcp.2011.09.030
21672929Sam68 mediates leptin-stimulated growth by modulating leptin receptor signaling in human trophoblastic JEG-3 cells.Hum Reprod2011 SepSanchez-Jimenez Fdoi: 10.1093/humrep/der187
21620750Sam68 is required for both NF-kB activation and apoptosis signaling by the TNF receptor.Mol Cell2011 Jul 22Ramakrishnan Pdoi: 10.1016/j.molcel.2011.05.007
21565971The RNA-binding protein Sam68 is a multifunctional player in human cancer.Endocr Relat Cancer2011 Jul 1Bielli Pdoi: 10.1530/ERC-11-0041
20662004Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells.J Pathol2010 NovSong Ldoi: 10.1002/path.2751.
20610388Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain.J Biol Chem2010 Sep 10Meyer NHdoi: 10.1074/jbc.M110.126185
27236696Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury.Cell Mol Neurobiol2017 AprChen Xdoi: 10.1007/s10571-016-0384-x
26438629The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs.J Mol Histol2015 DecZhang Tdoi: 10.1007/s10735-015-9639-y
29026317High expression of Sam68 in sacral chordomas is associated with worse clinical outcomes.Onco Targets Ther2017 Sep 22Wen Hdoi: 10.2147/OTT.S147446
10196249Cleavage of RasGAP and phosphorylation of mitogen-activated protein kinase in the course of coxsackievirus B3 replication.J Virol1999 MayHuber M-
9341174Specificity and determinants of Sam68 RNA binding. Implications for the biological function of K homology domains.J Biol Chem1997 Oct 24Lin Q-
8344248The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.EMBO J1993 AugMcGlade J-
12112020Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling.J Cell Biochem2002Najib S-
11604231Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling.Mol Cell Endocrinol2001 Oct 25Sanchez-Margalet V-
16045742Sam68 is tyrosine phosphorylated and recruited to signalling in peripheral blood mononuclear cells from HIV infected patients.Clin Exp Immunol2005 SepNajib S-
20186123The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy.EMBO J2010 Apr 7Pedrotti Sdoi: 10.1038/emboj.2010.19
17890166The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.Biochim Biophys Acta2007 OctUlke-Lemee A-
22745667Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.PLoS One2012Asbach Bdoi: 10.1371/journal.pone.0038540
26080397Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68.Proc Natl Acad Sci U S A2015 Jun 30Nakka KKdoi: 10.1073/pnas.1418603112
10564820Salpalpha and Salpbeta, growth-arresting homologs of Sam68.Gene1999 Nov 15Lee J-
7530715P62 association with RNA is regulated by tyrosine phosphorylation.J Biol Chem1995 Feb 3Wang LL-
7537265Functional interaction between c-Src and its mitotic target, Sam 68.J Biol Chem1995 Apr 28Taylor SJ-
10077576Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.Proc Natl Acad Sci U S A1999 Mar 16Di Fruscio M-
9804767The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins.J Biol Chem1998 Nov 13Di Fruscio M-
9671495Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization.Mol Cell Biol1998 AugChen T-
9633516KH domain integrity is required for wild-type localization of Sam68.Exp Cell Res1998 May 25McBride AE-
10473643A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines.Mol Biol Cell1999 SepChen T-
9315091Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis.Oncogene1997 SepResnick RJ-
9202153Identification of a novel nuclear localization signal in Sam68.FEBS Lett1997 Jun 9Ishidate T-
9045636Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.J Biol Chem1997 Mar 7Fusaki N-
9052995Insulin-induced tyrosine phosphorylation of a M(r) 70,000 protein revealed by association with the Src homology 2 (SH2) and SH3 domains of p120GAP and Grb2.Cell Growth Differ1996 AprMedema JP-
9010224The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68.Oncogene1997 Jan 16Lawe DC-
9013542A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain.J Biol Chem1997 Feb 7Barlat I-
8995379The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.J Biol Chem1997 Jan 10Trub T-
8720131Phosphorylation of HS1, GAP-associated p190 and a novel GAP-associated p60 protein by cross-linking of Fc gamma RIIIA.J Biochem1995 DecZeng H-
8637866Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells.Proc Natl Acad Sci U S A1996 Mar 19McBride AE-
8405383The KH domain occurs in a diverse set of RNA-binding proteins that include the antiterminator NusA and is probably involved in binding to nucleic acid.FEBS Lett1993 Jun 21Gibson TJ-
8419471Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins.J Immunol1993 Jan 15Gold MR-
10332027T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.Hum Mol Genet1999 JunVenables JP-
10353598Regulation of mRNA splicing and transport by the tyrosine kinase activity of src.Oncogene1999 Apr 22Gondran P-
10358169Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes.J Immunol1999 Jun 15Lang V-
8063859Serum-induced signal transduction determines the peripheral location of beta-actin mRNA within the cell.J Cell Biol1994 SepHill MA-
16568089SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosis.Oncogene2006 Aug 17Babic I-
12785721The expression of Sam68, a protein involved in insulin signal transduction, is enhanced by insulin stimulation.Cell Mol Life Sci2003 AprSanchez-Margalet V-
12529443Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.Mol Biol Cell2003 JanCote J-
12478298Signal-dependent regulation of splicing via phosphorylation of Sam68.Nature2002 Dec 12Matter N-
12482964Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.Mol Cell Biol2003 JanCoyle JH-
11748924Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: possible role of Sam68.Cell Immunol2001 Sep 15Martin-Romero C-
11585385Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway.Cell Immunol2001 Jul 10Sanchez-Margalet V-
11032831Neoplastic transformation and tumorigenesis associated with sam68 protein deficiency in cultured murine fibroblasts.J Biol Chem2000 Dec 22Liu K-
10913193Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.Mol Cell Biol2000 AugDerry JJ-
16179349Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.J Biol Chem2005 Nov 18Lukong KE-
16772024Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes.BMC Genomics2006 Jun 13Korostynski M-
15039213Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer.Am J Pathol2004 AprParonetto MP-
14991841Somatodendritic localization and mRNA association of the splicing regulatory protein Sam68 in the hippocampus and cortex.J Neurosci Res2004 Mar 1Grange J-
14996936Depolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neurons.J Cell Sci2004 Mar 1Ben Fredj N-
14731619A mitotic function for Src?Trends Cell Biol1994 OctCourtneidge SA-
14647465Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68.Oncogene2003 Nov 27Paronetto MP-
20110258Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin.Nucleic Acids Res2010 MayBusa Rdoi: 10.1093/nar/gkq004
20028857Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68.Cancer Res2010 Jan 1Paronetto MPdoi: 10.1158/0008-5472.CAN-09-2788
19762470Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor.J Biol Chem2009 Nov 13Huot MEdoi: 10.1074/jbc.M109.018465
19535902Sam68 functions in nuclear export and translation of HIV-1 RNA.RNA Biol2009 Sep-OctHe JJ-
23018781Emerging roles for Sam68 in adipogenesis and neuronal development.RNA Biol2012 SepVogel Gdoi: 10.4161/rna.21409
18617690An induction gene trap screen in neural stem cells reveals an instructive function of the niche and identifies the splicing regulator sam68 as a tenascin-C-regulated target gene.Stem Cells2008 SepMoritz Sdoi: 10.1634/stemcells.2007-1095
18321792Dynamic expression of the RNA-binding protein Sam68 during mouse pre-implantation development.Gene Expr Patterns2008 MayParonetto MPdoi: 10.1016/j.gep.2008.01.005
18325609Motor coordination defects in mice deficient for the Sam68 RNA-binding protein.Behav Brain Res2008 Jun 3Lukong KEdoi: 10.1016/j.bbr.2008.01.010
18273831The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor.J Pathol2008 MayRajan Pdoi: 10.1002/path.2324.
18186019Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.Proteomics2008 JanKozielski Fdoi: 10.1002/pmic.200700534.
18077133Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.Cell Signal2008 FebLukong KE-
17927519Targeting the RNA-binding protein Sam68 as a treatment for cancer?Future Oncol2007 OctLukong KE-
17855053The association of Sam68 with Vav1 contributes to tumorigenesis.Cell Signal2007 DecLazer G-
17371836The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.J Cell Biol2007 Mar 26Paronetto MP-
17237817The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells.Oncogene2007 Jun 28Busa R-
17200140Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2.J Cell Sci2007 Jan 15Sergeant KA-
23382180RNA-binding protein Sam68 controls synapse number and local β-actin mRNA metabolism in dendrites.Proc Natl Acad Sci U S A2013 Feb 19Klein MEdoi: 10.1073/pnas.1209811110
22732506Co-regulation of survival of motor neuron and Bcl-xL expression: implications for neuroprotection in spinal muscular atrophy.Neuroscience2012 Sep 18Anderton RSdoi: 10.1016/j.neuroscience.2012.06.042
22745822The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs.PLoS One2012Messina Vdoi: 10.1371/journal.pone.0039729
22623775Herpes simplex virus 2 infection impacts stress granule accumulation.J Virol2012 AugFinnen RLdoi: 10.1128/JVI.00313-12
22424772The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis.Mol Cell2012 Apr 27Huot Medoi: 10.1016/j.molcel.2012.02.007
22280896The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells.Virology2012 Mar 30Lawrence Pdoi: 10.1016/j.virol.2011.12.019
21189685Post-translational regulation of star proteins and effects on their biological functions.Adv Exp Med Biol2010Sette C-
21189691Reaching for the stars: Linking RNA binding proteins to diseases.Adv Exp Med Biol2010Richard S-
21035519Leptin receptor activation increases Sam68 tyrosine phosphorylation and expression in human trophoblastic cells.Mol Cell Endocrinol2011 Jan 30Sanchez-Jimenez Fdoi: 10.1016/j.mce.2010.10.014
20890126Spinal muscular atrophy: a new player joins the battle for SMN2 exon 7 splicing.Cell Cycle2010 Oct 1Pedrotti S-
20881015Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development.Hum Mol Genet2010 Dec 15Bianchi Edoi: 10.1093/hmg/ddq422
20844127Regulatory mechanisms that mediate tenascin C-dependent inhibition of oligodendrocyte precursor differentiation.J Neurosci2010 Sep 15Czopka Tdoi: 10.1523/JNEUROSCI.4957-09.2010.
20730808The role of the RNA-binding protein Sam68 in mammary tumourigenesis.J Pathol2010 NovElliott DJdoi: 10.1002/path.2753.
20639695An emerging role for nuclear RNA-mediated responses to genotoxic stress.RNA Biol2010 Jul-AugBusa R-
27057671The nuclear protein Sam68 is recruited to the cytoplasmic stress granules during enterovirus 71 infection.Microb Pathog2016 JulZhang Hdoi: 10.1016/j.micpath.2016.04.001
25666188Sam68 is cleaved by caspases under apoptotic cell death induced by ionizing radiation.J Radiat Res2015 MarCho SJdoi: 10.1093/jrr/rru113
25605807Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis.Diabetes2015 JulWang Hdoi: 10.2337/db14-0528
24287914Role of Sam68 in post-transcriptional gene regulation.Int J Mol Sci2013 Nov 28Sanchez-Jimenez Fdoi: 10.3390/ijms141223402.
27845622Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing.Elife2016 Nov 15La Rosa Pdoi: 10.7554/eLife.20750.
26050229Sam68 promotes cellular proliferation and predicts poor prognosis in esophageal squamous cell carcinoma.Tumour Biol2015 NovWang Ydoi: 10.1007/s13277-015-3631-8
27377249The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL.J Cell Biol2016 Jul 4Mannen Tdoi: 10.1083/jcb.201601024.
27623016Sam68 is Overexpressed in Epithelial Ovarian Cancer and Promotes Tumor Cell Proliferation.Med Sci Monit2016 Sep 13Dong L-
27458801Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-kB activation.Elife2016 Jul 25Fu Kdoi: 10.7554/eLife.15018.
27415018Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells.PLoS One2016 Jul 14Perez-Perez Adoi: 10.1371/journal.pone.0158218
27059137Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush.Biochem Biophys Res Commun2016 May 13Wu Wdoi: 10.1016/j.bbrc.2016.04.013
26310125The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7.Sci Rep2015 Aug 27Stockley Jdoi: 10.1038/srep13426.
26202240Nuclear Protein Sam68 Interacts with the Enterovirus 71 Internal Ribosome Entry Site and Positively Regulates Viral Protein Translation.J Virol2015 OctZhang Hdoi: 10.1128/JVI.01677-15
25944080Utility of SAM68 in the progression and prognosis for bladder cancer.BMC Cancer2015 May 6Zhang Zdoi: 10.1186/s12885-015-1367-x.
25776557Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis.Mol Cell Biol2015 Jun 1Song Jdoi: 10.1128/MCB.01488-14
28548969-----
29137239Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets.Oncotarget2017 May 11Li Ndoi: 10.18632/oncotarget.17813
29374200Interplay between TETs and microRNAs in the adult brain for memory formation.Sci Rep2018 Jan 26Kremer EAdoi: 10.1038/s41598-018-19806-z.
29386330SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA.Genes Dev2018 Jan 1Tichon Adoi: 10.1101/gad.309138.117
29808484A novel mutation in KHDRBS1 in a patient affected by primary ovarian insufficiency.Clin Endocrinol (Oxf)2018 May 28Carlosama Cdoi: 10.1111/cen.13749
30258098The RNA binding protein Sam68 controls T helper 1 differentiation and anti-mycobacterial response through modulation of miR-29.Cell Death Differ2019 JunVolpe Edoi: 10.1038/s41418-018-0201-9
25753412Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD.Cell Rep2015 Mar 10Klein MEdoi: 10.1016/j.celrep.2015.02.020
31072811The Promoter-Associated Noncoding RNA pncCCND1_B Assembles a Protein-RNA Complex to Regulate Cyclin D1 Transcription in Ewing Sarcoma.Cancer Res2019 Jul 15Palombo Rdoi: 10.1158/0008-5472.CAN-18-2403
15657085Satellite DNA binding and cellular localisation of RNA helicase P68.J Cell Sci2005 Feb 1Enukashvily N-
26695943Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections.Virol J2015 Dec 23Rai DKdoi: 10.1186/s12985-015-0452-8.
2172924A 62,000 molecular weight spliceosome protein crosslinks to the intron polypyrimidine tract.Nucleic Acids Res1990 Oct 25Wang J-
18183298Signal-regulated Pre-mRNA occupancy by the general splicing factor U2AF.PLoS One2008 Jan 9Tisserant Adoi: 10.1371/journal.pone.0001418.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000484270KHDRBS1-2031989NR_073499-- (aa)--
ENST00000327300KHDRBS1-2022757-ENSP00000313829443 (aa)-Q07666
ENST00000492989KHDRBS1-2041215-ENSP00000417731404 (aa)-Q07666
ENST00000307714KHDRBS1-2012738NR_073498-- (aa)--
Gene Model
Click here to download ENSG00000121774's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000121774Platelet Function Tests2.7909900E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000121774's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000121774KHDRBS17862.040ENSG00000112232KHDRBS29960.773
ENSG00000121774KHDRBS17857.821ENSG00000131773KHDRBS39568.831
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000121774KHDRBS18054.061ENSAPOG00000011054khdrbs1a9555.297Acanthochromis_polyacanthus
ENSG00000121774KHDRBS17866.391ENSAPOG00000000893khdrbs1b10063.288Acanthochromis_polyacanthus
ENSG00000121774KHDRBS110094.131ENSAMEG00000007969KHDRBS110094.131Ailuropoda_melanoleuca
ENSG00000121774KHDRBS17866.298ENSACIG00000006462khdrbs1b10064.130Amphilophus_citrinellus
ENSG00000121774KHDRBS18057.333ENSACIG00000015350khdrbs1a9557.029Amphilophus_citrinellus
ENSG00000121774KHDRBS17866.667ENSAOCG00000005657khdrbs1b10063.562Amphiprion_ocellaris
ENSG00000121774KHDRBS18056.684ENSAOCG00000018612khdrbs1a9556.989Amphiprion_ocellaris
ENSG00000121774KHDRBS18053.807ENSAPEG00000021382khdrbs1a9555.297Amphiprion_percula
ENSG00000121774KHDRBS17866.391ENSAPEG00000003469khdrbs1b10063.288Amphiprion_percula
ENSG00000121774KHDRBS18353.518ENSATEG00000005443khdrbs1a9953.750Anabas_testudineus
ENSG00000121774KHDRBS17862.334ENSATEG00000007550khdrbs1b10062.873Anabas_testudineus
ENSG00000121774KHDRBS17386.626ENSAPLG00000006587KHDRBS110088.450Anas_platyrhynchos
ENSG00000121774KHDRBS17884.814ENSACAG00000011693KHDRBS110086.040Anolis_carolinensis
ENSG00000121774KHDRBS1100100.000ENSANAG00000026939KHDRBS1100100.000Aotus_nancymaae
ENSG00000121774KHDRBS17865.847ENSACLG00000012927khdrbs1b10063.587Astatotilapia_calliptera
ENSG00000121774KHDRBS18056.736ENSACLG00000003959khdrbs1a9556.883Astatotilapia_calliptera
ENSG00000121774KHDRBS17957.600ENSAMXG00000002827khdrbs1a9560.705Astyanax_mexicanus
ENSG00000121774KHDRBS17862.429ENSAMXG00000011853khdrbs1b10065.634Astyanax_mexicanus
ENSG00000121774KHDRBS110099.549ENSBTAG00000012497KHDRBS110099.549Bos_taurus
ENSG00000121774KHDRBS1100100.000ENSCJAG00000006580KHDRBS181100.000Callithrix_jacchus
ENSG00000121774KHDRBS19997.738ENSCAFG00000010777KHDRBS110099.764Canis_familiaris
ENSG00000121774KHDRBS110099.774ENSCAFG00020025153KHDRBS110099.774Canis_lupus_dingo
ENSG00000121774KHDRBS110099.549ENSCHIG00000013092KHDRBS110099.549Capra_hircus
ENSG00000121774KHDRBS110094.131ENSTSYG00000004921KHDRBS110094.131Carlito_syrichta
ENSG00000121774KHDRBS110099.097ENSCPOG00000024148KHDRBS110099.097Cavia_porcellus
ENSG00000121774KHDRBS110090.745ENSCCAG00000034524KHDRBS110090.745Cebus_capucinus
ENSG00000121774KHDRBS1100100.000ENSCATG00000044448KHDRBS1100100.000Cercocebus_atys
ENSG00000121774KHDRBS110099.323ENSCLAG00000015761KHDRBS110099.323Chinchilla_lanigera
ENSG00000121774KHDRBS1100100.000ENSCSAG00000001043KHDRBS181100.000Chlorocebus_sabaeus
ENSG00000121774KHDRBS185100.000ENSCHOG00000006973KHDRBS185100.000Choloepus_hoffmanni
ENSG00000121774KHDRBS110081.982ENSCPBG00000011092KHDRBS19190.155Chrysemys_picta_bellii
ENSG00000121774KHDRBS185100.000ENSCANG00000039547KHDRBS1100100.000Colobus_angolensis_palliatus
ENSG00000121774KHDRBS110095.260ENSCGRG00001018212Khdrbs110095.260Cricetulus_griseus_chok1gshd
ENSG00000121774KHDRBS110095.260ENSCGRG00000007017Khdrbs110095.260Cricetulus_griseus_crigri
ENSG00000121774KHDRBS17866.759ENSCSEG00000011915khdrbs1b10063.736Cynoglossus_semilaevis
ENSG00000121774KHDRBS18552.475ENSCSEG00000000180khdrbs1a9454.933Cynoglossus_semilaevis
ENSG00000121774KHDRBS17856.720ENSCVAG00000012845khdrbs1a9956.952Cyprinodon_variegatus
ENSG00000121774KHDRBS17263.609ENSCVAG00000016032khdrbs1b9960.117Cyprinodon_variegatus
ENSG00000121774KHDRBS17861.453ENSDARG00000070475khdrbs1b10065.169Danio_rerio
ENSG00000121774KHDRBS17856.098ENSDARG00000052856khdrbs1a10056.806Danio_rerio
ENSG00000121774KHDRBS110098.194ENSDNOG00000039857KHDRBS110098.194Dasypus_novemcinctus
ENSG00000121774KHDRBS110095.485ENSDORG00000011530Khdrbs110094.808Dipodomys_ordii
ENSG00000121774KHDRBS110099.549ENSEASG00005010927KHDRBS110099.549Equus_asinus_asinus
ENSG00000121774KHDRBS110099.549ENSECAG00000019346KHDRBS110099.549Equus_caballus
ENSG00000121774KHDRBS17862.712ENSELUG00000003895khdrbs1a10062.360Esox_lucius
ENSG00000121774KHDRBS17861.351ENSELUG00000018597khdrbs1b9963.215Esox_lucius
ENSG00000121774KHDRBS110099.774ENSFCAG00000006511KHDRBS110099.774Felis_catus
ENSG00000121774KHDRBS110092.325ENSFDAG00000009053KHDRBS110092.325Fukomys_damarensis
ENSG00000121774KHDRBS17856.183ENSFHEG00000017506khdrbs1a9955.882Fundulus_heteroclitus
ENSG00000121774KHDRBS17863.014ENSFHEG00000017102khdrbs1b10063.043Fundulus_heteroclitus
ENSG00000121774KHDRBS15971.667ENSGMOG00000011695khdrbs1a7370.899Gadus_morhua
ENSG00000121774KHDRBS18682.908ENSGALG00000003272KHDRBS19185.063Gallus_gallus
ENSG00000121774KHDRBS17856.183ENSGAFG00000017614khdrbs1a9955.376Gambusia_affinis
ENSG00000121774KHDRBS17864.286ENSGAFG00000018819khdrbs1b10062.568Gambusia_affinis
ENSG00000121774KHDRBS17955.145ENSGACG00000006577khdrbs1a9954.839Gasterosteus_aculeatus
ENSG00000121774KHDRBS17154.252ENSGACG00000009219khdrbs1b9952.312Gasterosteus_aculeatus
ENSG00000121774KHDRBS110079.279ENSGAGG00000000937KHDRBS19090.237Gopherus_agassizii
ENSG00000121774KHDRBS1100100.000ENSGGOG00000008633KHDRBS1100100.000Gorilla_gorilla
ENSG00000121774KHDRBS18056.736ENSHBUG00000015400khdrbs1a9556.883Haplochromis_burtoni
ENSG00000121774KHDRBS17865.847ENSHBUG00000023083khdrbs1b10063.587Haplochromis_burtoni
ENSG00000121774KHDRBS110099.323ENSHGLG00000011935KHDRBS110099.323Heterocephalus_glaber_female
ENSG00000121774KHDRBS110094.808ENSHGLG00100008915KHDRBS110094.808Heterocephalus_glaber_male
ENSG00000121774KHDRBS17860.623ENSHCOG00000018060khdrbs1b9958.696Hippocampus_comes
ENSG00000121774KHDRBS17853.968ENSHCOG00000014480khdrbs1a9954.032Hippocampus_comes
ENSG00000121774KHDRBS17959.467ENSIPUG00000019749khdrbs1a9760.800Ictalurus_punctatus
ENSG00000121774KHDRBS17868.362ENSIPUG00000014237Khdrbs110068.362Ictalurus_punctatus
ENSG00000121774KHDRBS110099.549ENSSTOG00000014138KHDRBS110099.549Ictidomys_tridecemlineatus
ENSG00000121774KHDRBS110097.291ENSJJAG00000016809Khdrbs110097.291Jaculus_jaculus
ENSG00000121774KHDRBS17856.150ENSKMAG00000014883khdrbs1a9956.417Kryptolebias_marmoratus
ENSG00000121774KHDRBS17867.123ENSKMAG00000001634khdrbs1b10064.130Kryptolebias_marmoratus
ENSG00000121774KHDRBS17854.062ENSLBEG00000025137khdrbs1a9354.497Labrus_bergylta
ENSG00000121774KHDRBS17858.127ENSLBEG00000009832khdrbs1b10057.377Labrus_bergylta
ENSG00000121774KHDRBS17177.673ENSLACG00000010345KHDRBS110077.358Latimeria_chalumnae
ENSG00000121774KHDRBS17975.630ENSLOCG00000002273khdrbs1a9973.315Lepisosteus_oculatus
ENSG00000121774KHDRBS18798.182ENSLAFG00000009414KHDRBS19998.182Loxodonta_africana
ENSG00000121774KHDRBS1100100.000ENSMFAG00000001194KHDRBS1100100.000Macaca_fascicularis
ENSG00000121774KHDRBS1100100.000ENSMNEG00000035607KHDRBS1100100.000Macaca_nemestrina
ENSG00000121774KHDRBS18199.722ENSMLEG00000032825KHDRBS19999.722Mandrillus_leucophaeus
ENSG00000121774KHDRBS18154.617ENSMAMG00000008449khdrbs1a10053.298Mastacembelus_armatus
ENSG00000121774KHDRBS17866.482ENSMAMG00000004312khdrbs1b10064.130Mastacembelus_armatus
ENSG00000121774KHDRBS17865.847ENSMZEG00005000823khdrbs1b10063.587Maylandia_zebra
ENSG00000121774KHDRBS18056.736ENSMZEG00005027048khdrbs1a9556.883Maylandia_zebra
ENSG00000121774KHDRBS17384.592ENSMGAG00000004455KHDRBS110087.613Meleagris_gallopavo
ENSG00000121774KHDRBS110099.549ENSMICG00000001428KHDRBS18199.549Microcebus_murinus
ENSG00000121774KHDRBS110095.485ENSMOCG00000022233Khdrbs110095.485Microtus_ochrogaster
ENSG00000121774KHDRBS17860.795ENSMMOG00000021224khdrbs1b10060.000Mola_mola
ENSG00000121774KHDRBS17859.207ENSMMOG00000002147khdrbs1a9959.605Mola_mola
ENSG00000121774KHDRBS110088.667ENSMODG00000017551-10088.889Monodelphis_domestica
ENSG00000121774KHDRBS17864.722ENSMALG00000000347khdrbs1b10064.033Monopterus_albus
ENSG00000121774KHDRBS18056.955ENSMALG00000005558khdrbs1a9555.556Monopterus_albus
ENSG00000121774KHDRBS110094.357MGP_CAROLIEiJ_G0026534Khdrbs110094.357Mus_caroli
ENSG00000121774KHDRBS110094.357ENSMUSG00000028790Khdrbs110094.357Mus_musculus
ENSG00000121774KHDRBS110093.002MGP_PahariEiJ_G0028866Khdrbs110093.002Mus_pahari
ENSG00000121774KHDRBS110094.357MGP_SPRETEiJ_G0027514Khdrbs110094.357Mus_spretus
ENSG00000121774KHDRBS110099.774ENSMPUG00000015353KHDRBS110099.774Mustela_putorius_furo
ENSG00000121774KHDRBS110098.194ENSMLUG00000008109KHDRBS110098.194Myotis_lucifugus
ENSG00000121774KHDRBS110096.840ENSNGAG00000021015Khdrbs110096.840Nannospalax_galili
ENSG00000121774KHDRBS17866.393ENSNBRG00000000441khdrbs1b10063.587Neolamprologus_brichardi
ENSG00000121774KHDRBS18056.736ENSNBRG00000000382khdrbs1a9556.883Neolamprologus_brichardi
ENSG00000121774KHDRBS17398.142ENSNLEG00000002148-9786.118Nomascus_leucogenys
ENSG00000121774KHDRBS15497.561ENSMEUG00000015720-10072.063Notamacropus_eugenii
ENSG00000121774KHDRBS19389.051ENSOPRG00000005131KHDRBS110089.051Ochotona_princeps
ENSG00000121774KHDRBS18056.331ENSONIG00000012217khdrbs1a9656.218Oreochromis_niloticus
ENSG00000121774KHDRBS18065.600ENSONIG00000007705khdrbs1b10062.865Oreochromis_niloticus
ENSG00000121774KHDRBS15892.969ENSOANG00000012357-9280.952Ornithorhynchus_anatinus
ENSG00000121774KHDRBS110099.323ENSOCUG00000007654KHDRBS110099.323Oryctolagus_cuniculus
ENSG00000121774KHDRBS17864.738ENSORLG00000020884khdrbs1b10062.295Oryzias_latipes
ENSG00000121774KHDRBS17956.349ENSORLG00000017156khdrbs1a9955.676Oryzias_latipes
ENSG00000121774KHDRBS17956.568ENSORLG00020003020khdrbs1a9755.496Oryzias_latipes_hni
ENSG00000121774KHDRBS17865.014ENSORLG00015008545khdrbs1b10062.568Oryzias_latipes_hsok
ENSG00000121774KHDRBS18056.053ENSORLG00015017288khdrbs1a9855.000Oryzias_latipes_hsok
ENSG00000121774KHDRBS17855.080ENSOMEG00000017158khdrbs1a9955.080Oryzias_melastigma
ENSG00000121774KHDRBS19260.706ENSOMEG00000004739khdrbs1b10060.656Oryzias_melastigma
ENSG00000121774KHDRBS110099.550ENSOGAG00000004582KHDRBS110099.550Otolemur_garnettii
ENSG00000121774KHDRBS110086.907ENSOARG00000000666KHDRBS110086.907Ovis_aries
ENSG00000121774KHDRBS1100100.000ENSPPAG00000035456KHDRBS1100100.000Pan_paniscus
ENSG00000121774KHDRBS110099.774ENSPPRG00000009461KHDRBS110099.774Panthera_pardus
ENSG00000121774KHDRBS184100.000ENSPTIG00000007835KHDRBS184100.000Panthera_tigris_altaica
ENSG00000121774KHDRBS1100100.000ENSPTRG00000000469KHDRBS1100100.000Pan_troglodytes
ENSG00000121774KHDRBS1100100.000ENSPANG00000023230KHDRBS181100.000Papio_anubis
ENSG00000121774KHDRBS17860.504ENSPKIG00000011578khdrbs1a10057.064Paramormyrops_kingsleyae
ENSG00000121774KHDRBS17872.805ENSPKIG00000024687khdrbs1b10071.875Paramormyrops_kingsleyae
ENSG00000121774KHDRBS17391.950ENSPSIG00000005721KHDRBS19991.950Pelodiscus_sinensis
ENSG00000121774KHDRBS110095.485ENSPEMG00000024209Khdrbs110095.485Peromyscus_maniculatus_bairdii
ENSG00000121774KHDRBS17848.930ENSPMAG00000004531khdrbs1a10045.736Petromyzon_marinus
ENSG00000121774KHDRBS110088.222ENSPCIG00000022322KHDRBS110088.444Phascolarctos_cinereus
ENSG00000121774KHDRBS17866.027ENSPFOG00000012131khdrbs1b10062.500Poecilia_formosa
ENSG00000121774KHDRBS17957.784ENSPFOG00000022410khdrbs1a10056.658Poecilia_formosa
ENSG00000121774KHDRBS17866.027ENSPLAG00000000612khdrbs1b10062.500Poecilia_latipinna
ENSG00000121774KHDRBS17856.452ENSPLAG00000000511khdrbs1a9955.645Poecilia_latipinna
ENSG00000121774KHDRBS17866.575ENSPMEG00000019927khdrbs1b10063.043Poecilia_mexicana
ENSG00000121774KHDRBS17856.452ENSPREG00000021975khdrbs1a9955.645Poecilia_reticulata
ENSG00000121774KHDRBS17866.027ENSPREG00000016786khdrbs1b10062.772Poecilia_reticulata
ENSG00000121774KHDRBS1100100.000ENSPPYG00000001605KHDRBS181100.000Pongo_abelii
ENSG00000121774KHDRBS110098.646ENSPCAG00000009844KHDRBS110098.646Procavia_capensis
ENSG00000121774KHDRBS19292.857ENSPCOG00000024908-9294.286Propithecus_coquereli
ENSG00000121774KHDRBS110099.323ENSPCOG00000019588-10099.323Propithecus_coquereli
ENSG00000121774KHDRBS110099.097ENSPVAG00000013289KHDRBS110099.097Pteropus_vampyrus
ENSG00000121774KHDRBS17865.847ENSPNYG00000004607khdrbs1b10063.587Pundamilia_nyererei
ENSG00000121774KHDRBS18056.736ENSPNYG00000001540khdrbs1a9556.883Pundamilia_nyererei
ENSG00000121774KHDRBS17864.426ENSPNAG00000029804khdrbs1b10065.449Pygocentrus_nattereri
ENSG00000121774KHDRBS17957.333ENSPNAG00000015629khdrbs1a8059.946Pygocentrus_nattereri
ENSG00000121774KHDRBS110094.357ENSRNOG00000046794Khdrbs110094.357Rattus_norvegicus
ENSG00000121774KHDRBS1100100.000ENSRBIG00000028373KHDRBS1100100.000Rhinopithecus_bieti
ENSG00000121774KHDRBS1100100.000ENSRROG00000043518KHDRBS181100.000Rhinopithecus_roxellana
ENSG00000121774KHDRBS183100.000ENSSBOG00000031548KHDRBS1100100.000Saimiri_boliviensis_boliviensis
ENSG00000121774KHDRBS18195.518ENSSHAG00000007106KHDRBS19995.518Sarcophilus_harrisii
ENSG00000121774KHDRBS17863.483ENSSFOG00015023564-9960.548Scleropages_formosus
ENSG00000121774KHDRBS19462.937ENSSFOG00015007055khdrbs1b10069.405Scleropages_formosus
ENSG00000121774KHDRBS17863.661ENSSMAG00000020593khdrbs1b10064.130Scophthalmus_maximus
ENSG00000121774KHDRBS18054.337ENSSMAG00000007244khdrbs1a9554.264Scophthalmus_maximus
ENSG00000121774KHDRBS17865.301ENSSDUG00000001503khdrbs1b10064.402Seriola_dumerili
ENSG00000121774KHDRBS18055.325ENSSDUG00000010794khdrbs1a9555.556Seriola_dumerili
ENSG00000121774KHDRBS17864.033ENSSLDG00000005200khdrbs1b10063.144Seriola_lalandi_dorsalis
ENSG00000121774KHDRBS18055.325ENSSLDG00000002979khdrbs1a9555.556Seriola_lalandi_dorsalis
ENSG00000121774KHDRBS18298.730ENSSARG00000008479KHDRBS18298.730Sorex_araneus
ENSG00000121774KHDRBS17991.292ENSSPUG00000017881KHDRBS19090.256Sphenodon_punctatus
ENSG00000121774KHDRBS17866.301ENSSPAG00000000646khdrbs1b10063.215Stegastes_partitus
ENSG00000121774KHDRBS17856.053ENSSPAG00000020848khdrbs1a9956.319Stegastes_partitus
ENSG00000121774KHDRBS110099.774ENSSSCG00000023122KHDRBS110099.774Sus_scrofa
ENSG00000121774KHDRBS17864.738ENSTRUG00000010001khdrbs1b10062.295Takifugu_rubripes
ENSG00000121774KHDRBS17856.911ENSTRUG00000012039khdrbs1a9956.032Takifugu_rubripes
ENSG00000121774KHDRBS17965.395ENSTNIG00000013071khdrbs1b10062.331Tetraodon_nigroviridis
ENSG00000121774KHDRBS18058.333ENSTNIG00000017471khdrbs1a10057.447Tetraodon_nigroviridis
ENSG00000121774KHDRBS17196.190ENSTBEG00000016857KHDRBS110096.190Tupaia_belangeri
ENSG00000121774KHDRBS110099.774ENSTTRG00000009637KHDRBS110099.774Tursiops_truncatus
ENSG00000121774KHDRBS110099.774ENSUAMG00000009175KHDRBS110099.774Ursus_americanus
ENSG00000121774KHDRBS178100.000ENSUMAG00000008568KHDRBS1100100.000Ursus_maritimus
ENSG00000121774KHDRBS110099.549ENSVPAG00000006966KHDRBS110099.549Vicugna_pacos
ENSG00000121774KHDRBS110099.774ENSVVUG00000015032KHDRBS110099.774Vulpes_vulpes
ENSG00000121774KHDRBS18175.068ENSXETG00000005246khdrbs110076.923Xenopus_tropicalis
ENSG00000121774KHDRBS17858.310ENSXCOG00000011027khdrbs1a9955.801Xiphophorus_couchianus
ENSG00000121774KHDRBS17856.183ENSXMAG00000006419khdrbs1a9955.376Xiphophorus_maculatus
ENSG00000121774KHDRBS17866.849ENSXMAG00000005713khdrbs1b10063.315Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000086G2/M transition of mitotic cell cycle-ISSProcess
GO:0000381regulation of alternative mRNA splicing, via spliceosome24514149.IDAProcess
GO:0003677DNA binding1374686.TASFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding1374686.IDAFunction
GO:0005070SH3/SH2 adaptor activity9045636.IPIFunction
GO:0005515protein binding7537265.7852312.9045636.10332027.10749975.10913193.11278465.11585385.12029088.16107303.16169070.16341228.16888650.17141806.17371836.17855053.20186123.20936779.21706016.21988832.22000517.22641034.24514149.26496610.IPIFunction
GO:0005634nucleus1374686.29496907.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm29496907.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006397mRNA processing-IEAProcess
GO:0007050cell cycle arrest9013542.TASProcess
GO:0007165signal transduction9013542.TASProcess
GO:0007166cell surface receptor signaling pathway9045636.IDAProcess
GO:0007283spermatogenesis-IEAProcess
GO:0008143poly(A) binding21984414.IDAFunction
GO:0008266poly(U) RNA binding21984414.IDAFunction
GO:0008283cell proliferation9013542.TASProcess
GO:0009967positive regulation of signal transduction-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016020membrane1374686.IDAComponent
GO:0017124SH3 domain binding-IEAFunction
GO:0019904protein domain specific binding10749975.IPIFunction
GO:0031647regulation of protein stability21613532.IDAProcess
GO:0042802identical protein binding10332027.10749975.IDAFunction
GO:0042802identical protein binding20186123.22365833.24514149.IPIFunction
GO:0044877protein-containing complex binding-IEAFunction
GO:0045892negative regulation of transcription, DNA-templated-ISSProcess
GO:0045948positive regulation of translational initiation21613532.IDAProcess
GO:0046831regulation of RNA export from nucleus-ISSProcess
GO:0046833positive regulation of RNA export from nucleus21613532.IDAProcess
GO:0051259protein complex oligomerization10332027.10749975.IDAProcess
GO:0070618Grb2-Sos complex-IEAComponent
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