EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24061479Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.Mol Cell Biol2013 DecTeng Tdoi: 10.1128/MCB.01174-13
23478443Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence.Mol Cell2013 Apr 11Fregoso OIdoi: 10.1016/j.molcel.2013.02.001
17116689Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.Mol Cell Biol2007 FebLindstrm MS-
28147343The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types.Oncotarget2017 Feb 28Fancello Ldoi: 10.18632/oncotarget.14895.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr192834778Splice_SiteNAX64_splice0.46
BLCAchr192833393Missense_MutationnovelF3C0.48
BLCAchr192837352Intronnovel0.27
BLCAchr192836277Nonsense_MutationnovelQ138*0.3
BRCAchr1928320795'UTRnovel0.23
BRCAchr192832999IntronNA0.2
BRCAchr192833648Frame_Shift_DelnovelI60Vfs*80.21
BRCAchr192833489Intronnovel0.51
BRCAchr192834879Missense_MutationNAA97G0.36
BRCAchr192832894Intronnovel0.08
BRCAchr1928418943'UTRnovel0.4
BRCAchr192833631Missense_Mutationrs764649729R54C0.17
BRCAchr192836195SilentNAL110L0.27
CESCchr192837554Missense_Mutationrs775560628R209H0.32
CESCchr192837351Intronrs3749938510.44
CESCchr1928419243'UTRrs5656618270.21
CESCchr192833041Intronnovel0.43
CESCchr192837375IntronNA0.17
CESCchr192836195SilentnovelL110L0.59
COADchr192836239Missense_MutationNAV125A0.37
COADchr192837547Missense_Mutationrs746120360Y207H0.32
COADchr192833469Intronnovel0.41
COADchr192841848Missense_Mutationrs200315052R293W0.18
COADchr192834833Missense_MutationNAE82K0.3
COADchr192836239Missense_MutationNAV125A0.31
COADchr192834824Missense_MutationnovelY79H0.27
GBMchr192833398Frame_Shift_DelNAV6Lfs*130.38
GBMchr192836227Missense_MutationNAG121V0.06
GBMchr192833433Nonsense_Mutationrs148673599Y16*0.25
GBMchr192834801Missense_MutationNAG71E0.13
GBMchr192833053Intronnovel0.54
GBMchr192836340Frame_Shift_InsnovelG161Wfs*240.55
GBMchr192837353Intronnovel0.03
GBMchr192833656Missense_MutationnovelC62Y0.3
GBMchr192840629Frame_Shift_DelnovelK263Rfs*180.1
GBMchr192837604Missense_MutationNAY226H0.24
GBMchr192833539Splice_Regionnovel0.22
HNSCchr192836219SilentnovelI118I0.07
HNSCchr192836382Missense_Mutationrs754245145I173V0.33
HNSCchr192840797Intronrs7779554350.15
KIRCchr192833603Nonsense_MutationNAY44*0.26
KIRPchr1928320775'UTRrs3720809020.33
LGGchr192834821Missense_MutationnovelA78P0.41
LGGchr192836357Missense_MutationnovelK164N0.06
LIHCchr192841848Missense_Mutationrs200315052R293W0.29
LIHCchr192833648Missense_MutationnovelD59E0.17
LUADchr192834901SilentnovelL104L0.41
LUADchr192840547Splice_SitenovelX236_splice0.12
LUADchr192834872Frame_Shift_DelnovelY95Wfs*210.13
LUADchr192840823Intronnovel0.08
LUADchr192836277Frame_Shift_DelnovelP139Vfs*240.12
LUADchr192833661Splice_SitenovelX63_splice0.29
LUADchr192840557Nonsense_MutationNAE238*0.24
LUADchr192837512Missense_MutationnovelH195L0.88
LUADchr192834894Missense_MutationnovelG102V0.19
LUSCchr1928320615'UTRrs7558781940.27
LUSCchr1928320625'UTRnovel0.27
LUSCchr192837314Intronnovel0.08
LUSCchr192836326Missense_MutationNAT154I0.35
LUSCchr192833454Splice_SitenovelX23_splice0.11
OVchr192833592Nonsense_MutationnovelK41*0.51
PRADchr192836331In_Frame_DelnovelG156del0.1
READchr1928320505'UTRnovel0.27
READchr192840619Missense_MutationNAK258N0.41
READchr192833614Missense_MutationnovelK48T0.15
READchr192841774Missense_Mutationrs765443248R268H0.39
SARCchr192834888Missense_MutationnovelC100F0.29
SARCchr192840596Missense_MutationnovelP251S0.18
SARCchr192836317Missense_MutationnovelA151V0.12
SKCMchr192836203Missense_MutationnovelF113C0.33
SKCMchr192837474SilentnovelG182G0.2
SKCMchr192833364Splice_SitenovelX2_splice0.1
SKCMchr192833612Frame_Shift_InsnovelY49*0.53
SKCMchr192834860Missense_Mutationrs371559214G91S0.26
SKCMchr192834861Missense_MutationnovelG91D0.26
SKCMchr192836392Missense_MutationNAS176N0.28
SKCMchr192833528Splice_Regionnovel0.16
SKCMchr192833398Nonsense_MutationNAK5*0.56
SKCMchr192837463Nonsense_MutationNAR179*0.36
SKCMchr192836386Missense_MutationnovelP174L0.26
SKCMchr192833631Missense_Mutationrs764649729R54C0.19
SKCMchr192833631Missense_Mutationrs764649729R54C0.14
SKCMchr192837530Missense_MutationnovelG201V0.49
SKCMchr192833631Missense_Mutationrs764649729R54C0.22
SKCMchr192833392Missense_MutationNAF3L0.35
STADchr192840723Intronnovel0.24
STADchr192837551Missense_MutationNAM208T0.06
STADchr192837295Intronnovel0.17
STADchr1928320695'UTRrs3762083110.13
STADchr192837551Missense_MutationNAM208T0.36
TGCTchr192834803Frame_Shift_InsnovelM73Ifs*20.22
THCAchr1928320775'UTRrs3720809020.2
THCAchr192833471Intronnovel0.29
UCECchr192833382Splice_Regionnovel0.25
UCECchr192840588Missense_Mutationrs749410848R248Q0.29
UCECchr192837619Missense_Mutationrs568863745V231I0.21
UCECchr192836297SilentnovelC144C0.21
UCECchr192833097Intronnovel0.36
UCECchr192834833Missense_MutationNAE82K0.47
UCECchr192837594SilentNAQ222Q0.35
UCECchr192834833Missense_MutationNAE82K0.51
UCECchr192834833Missense_MutationNAE82K0.4
UCECchr192834818Missense_Mutationrs752867126A77T0.42
UCECchr192837478Missense_MutationnovelD184Y0.26
UCECchr1928418833'UTRnovel0.41
UCECchr192837482Missense_MutationNAS185F0.17
UCECchr192833433SilentNAY16Y0.17
UCECchr192840755Intronnovel0.45
UCECchr192832980Intronnovel0.05
UCECchr192833333Intronnovel0.07
UCECchr192837554Missense_Mutationrs775560628R209H0.17
UCECchr192833258Intronnovel0.17
UCECchr192834818Missense_Mutationrs752867126A77T0.35
UCECchr192836274Missense_Mutationrs746606485G137C0.62
UCECchr192837453Splice_Regionnovel0.33
UCECchr192833530Intronnovel0.17
UCECchr192834861Missense_MutationnovelG91D0.36
UCECchr192837495Missense_MutationnovelE189D0.2
UCECchr192833314Intronnovel0.45
UCECchr192834823Silentrs778200458A78A0.49
UCECchr192837351Intronrs3749938510.35
UCECchr192841848Missense_Mutationrs200315052R293W0.39
UCECchr192837542Missense_MutationNAA205V0.21
UCECchr192833097Intronnovel0.5
UCECchr1928418873'UTRnovel0.44
UCECchr192834833Missense_MutationNAE82K0.4
UCECchr192837554Missense_Mutationrs775560628R209H0.38
UCECchr192833439SilentnovelV18V0.16
UCECchr192834833Missense_MutationNAE82K0.19
UCECchr192836191Missense_MutationnovelL109R0.13
UCECchr192837521Missense_MutationnovelH198R0.35
UCECchr192840623Nonsense_MutationnovelE260*0.27
UCECchr192834835Missense_Mutationrs771331683E82D0.34
UCECchr192833465Splice_Regionnovel0.5
UCECchr192834833Missense_MutationNAE82K0.35
UCECchr192837587Frame_Shift_InsnovelK221Nfs*30.13
UCECchr192837588SilentnovelK220K0.04
UCECchr192840619Missense_MutationNAK258N0.5
UCECchr192833117Intronnovel0.47
UCECchr192833321Intronnovel0.39
UCECchr192833620Missense_MutationnovelR50M0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.27965.7821e-10
CESCDEL0.08140.01281
COADDEL0.23060.00038973
GBMDEL0.07456.3283e-06
MESODEL0.41385.9874e-12
PRADDEL0.11590.0061054
SKCMDEL0.22899.7877e-07
STADDEL0.17690.0040659
TGCTAMP0.17330.088103

Survival Analysis
CancerP-value Q-value
THYM0.028

Kaplan-Meier Survival Analysis

SARC0.0001

Kaplan-Meier Survival Analysis

ACC0.0025

Kaplan-Meier Survival Analysis

SKCM0.026

Kaplan-Meier Survival Analysis

BRCA0.003

Kaplan-Meier Survival Analysis

KIRP0.014

Kaplan-Meier Survival Analysis

COAD0.038

Kaplan-Meier Survival Analysis

LAML0.044

Kaplan-Meier Survival Analysis

GBM0.017

Kaplan-Meier Survival Analysis

LIHC0.001

Kaplan-Meier Survival Analysis

LGG0.00058

Kaplan-Meier Survival Analysis

UVM0.023

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000122406 (Gene tree)
Gene ID
6125
Gene Symbol
RPL5
Alias
L5|PPP1R135|uL18
Full Name
ribosomal protein L5
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
9,942 bases
Position
chr1:92,831,983-92,841,924
Accession
10360
RBP type
non-canonical RBP
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26159998Chaperoning 5S RNA assembly.Genes Dev2015 Jul 1Madru Cdoi: 10.1101/gad.260349.115.
24141778Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex.Oncogene2014 Oct 9Liao JMdoi: 10.1038/onc.2013.430
25404745A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.J Cell Biol2014 Nov 24BaBler Jdoi: 10.1083/jcb.201408111
28369725RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.Br J Haematol2017 AprLee HCdoi: 10.1111/bjh.14525.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000497519RPL5-2051210--- (aa)--
ENST00000461952RPL5-2031116--- (aa)--
ENST00000644759RPL5-2081085-ENSP00000495549297 (aa)-P46777
ENST00000645300RPL5-210896-ENSP00000495589238 (aa)-A0A2R8Y6J3
ENST00000646852RPL5-212733--- (aa)--
ENST00000643510RPL5-206277--- (aa)--
ENST00000370321RPL5-2021028-ENSP00000359345297 (aa)-P46777
ENST00000644549RPL5-207271--- (aa)--
ENST00000645908RPL5-211591--- (aa)--
ENST00000645119RPL5-209629-ENSP00000493811170 (aa)-A0A2R8Y4A2
ENST00000315741RPL5-201681-ENSP00000359338130 (aa)-Q5T7N0
ENST00000470843RPL5-204694-ENSP0000047367563 (aa)-R4GNJ2
Gene Model
Click here to download ENSG00000122406's gene model file
Pathways
Pathway IDPathway NameSource
hsa03010RibosomeKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000122406Schizophrenia1.01E-5-
ENSG00000122406Schizophrenia7.36E-6-
ENSG00000122406Smoking1.2700000E-005-
ENSG00000122406Monocytes1.3470000E-00621738480
ENSG00000122406Multiple Sclerosis8E-617660530
ENSG00000122406Multiple Sclerosis3E-619525955
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000122406rs6604026192838046GMultiple sclerosis19525955[NR]1.17EFO_0003885
ENSG00000122406rs6604026192838046CMultiple sclerosis17660530[1.08-1.22]1.15EFO_0003885
ENSG00000122406rs189162117192839027?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122406's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000122406RPL510082.540WBGene00004416rpl-59958.362Caenorhabditis_elegans
ENSG00000122406RPL510085.714FBgn0064225RpL59768.621Drosophila_melanogaster
ENSG00000122406RPL510098.462ENSMUSG00000058558Rpl510098.773Mus_musculus
ENSG00000122406RPL510069.841YPL131WRPL59949.488Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000027ribosomal large subunit assembly21873635.IBAProcess
GO:0000027ribosomal large subunit assembly24120868.IMPProcess
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TASProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003730mRNA 3'-UTR binding16213212.IDAFunction
GO:0003735structural constituent of ribosome12962325.NASFunction
GO:0005515protein binding9465063.9687515.12054647.15314173.15469983.16648475.17110929.17373842.18560357.20434207.20926688.21399665.IPIFunction
GO:0005634nucleus9687515.IDAComponent
GO:0005654nucleoplasm24120868.IDAComponent
GO:0005730nucleolus16791210.HDAComponent
GO:0005730nucleolus15469983.24120868.IDAComponent
GO:0005737cytoplasm16791210.HDAComponent
GO:0005737cytoplasm15314173.15469983.IDAComponent
GO:0005783endoplasmic reticulum-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006364rRNA processing18697920.IMPProcess
GO:0006412translation12962325.NASProcess
GO:0006413translational initiation-TASProcess
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TASProcess
GO:00080975S rRNA binding21873635.IBAFunction
GO:00080975S rRNA binding18560357.IDAFunction
GO:0010628positive regulation of gene expression18560357.IDAProcess
GO:0016020membrane19946888.HDAComponent
GO:0019083viral transcription-TASProcess
GO:0022625cytosolic large ribosomal subunit12962325.HDAComponent
GO:0022625cytosolic large ribosomal subunit21873635.IBAComponent
GO:0031625ubiquitin protein ligase binding18560357.IPIFunction
GO:0032991protein-containing complex15314173.IDAComponent
GO:0042273ribosomal large subunit biogenesis18697920.IMPProcess
GO:0045202synapse-IEAComponent
GO:0045727positive regulation of translation16213212.IDAProcess
GO:0048027mRNA 5'-UTR binding16213212.IDAFunction
GO:0050821protein stabilization18560357.IMPProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:1901796regulation of signal transduction by p53 class mediator24120868.IMPProcess
GO:1904667negative regulation of ubiquitin protein ligase activity18560357.IDAProcess
GO:1990904ribonucleoprotein complex18809582.IDAComponent
GO:1990948ubiquitin ligase inhibitor activity18560357.IDAFunction
GO:2000059negative regulation of ubiquitin-dependent protein catabolic process18560357.IDAProcess
GO:2000435negative regulation of protein neddylation18560357.IDAProcess
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