EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18353764	Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.	Mol Cell Proteomics	2008 Jul	Thorsen K	doi: 10.1074/mcp.M700590-MCP200
26657294	Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer.	Oncotarget	2016 Jan 19	De Marchi T	doi: 10.18632/oncotarget.6521.
15958622	Low-molecular weight caldesmon as a potential serum marker for glioma.	Clin Cancer Res	2005 Jun 15	Zheng PP	-
17582218	Hela /-CaD undergoes a DNA replication-associated switch in localization from the cytoplasm to the nuclei of endothelial cells/endothelial progenitor cells in human tumor vasculature.	Cancer Biol Ther	2007 Jun	Zheng PP	-
23418348	cGMP-dependent protein kinase Iβ regulates breast cancer cell migration and invasion via interaction with the actin/myosin-associated protein caldesmon.	J Cell Sci	2013 Apr 1	Schwappacher R	doi: 10.1242/jcs.118190
23265641	Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein.	J Proteome Res	2013 Feb 1	Hou Q	doi: 10.1021/pr3010259
17631293	Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.	FEBS Lett	2007 Aug 7	Yoshio T	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr7	134960096	Silent	novel	A728A	0.21
ACC	chr7	134960240	Intron	novel		0.29
BLCA	chr7	134933946	Missense_Mutation	novel	E393K	0.14
BLCA	chr7	134968374	3'UTR	novel		0.36
BLCA	chr7	134933989	Missense_Mutation	novel	E407G	0.15
BLCA	chr7	134867756	Missense_Mutation	novel	R8T	0.19
BLCA	chr7	134941194	Missense_Mutation	novel	E497K	0.53
BLCA	chr7	134960404	Intron	novel		0.38
BLCA	chr7	134958267	Missense_Mutation	NA	E680K	0.54
BLCA	chr7	134950445	Missense_Mutation	NA	M622I	0.07
BLCA	chr7	134935766	Splice_Site	novel	X462_splice	0.5
BLCA	chr7	134933595	Missense_Mutation	novel	E276K	0.28
BLCA	chr7	134934045	Missense_Mutation	novel	D426H	0.05
BLCA	chr7	134933088	Missense_Mutation	rs775853439	R107C	0.45
BLCA	chr7	134958223	Missense_Mutation	NA	S665L	0.4
BLCA	chr7	134960531	Splice_Site	novel	X734_splice	0.06
BLCA	chr7	134960230	Intron	novel		0.18
BLCA	chr7	134960232	Intron	novel		0.18
BLCA	chr7	134934045	Missense_Mutation	novel	D426H	0.32
BLCA	chr7	134933086	Missense_Mutation	novel	R106T	0.17
BLCA	chr7	134933123	Silent	novel	Q118Q	0.21
BLCA	chr7	134933963	Silent	novel	A398A	0.32
BRCA	chr7	134958255	Missense_Mutation	NA	D676H	0.37
BRCA	chr7	134941155	Missense_Mutation	NA	R484G	0.37
BRCA	chr7	134935763	Missense_Mutation	novel	E462K	0.1
BRCA	chr7	134960635	Splice_Region	novel		0.23
BRCA	chr7	134960561	Missense_Mutation	NA	S743Y	0.37
BRCA	chr7	134933001	Missense_Mutation	NA	E78K	0.19
BRCA	chr7	134960409	Intron	novel		0.32
BRCA	chr7	134867789	Missense_Mutation	NA	R19Q	0.23
BRCA	chr7	134935694	Missense_Mutation	NA	E439Q	0.31
BRCA	chr7	134928790	Silent	NA	E36E	0.19
BRCA	chr7	134960153	Intron	novel		0.1
BRCA	chr7	134934014	Silent	NA	G415G	0.22
BRCA	chr7	134933834	Missense_Mutation	NA	E355D	0.42
CESC	chr7	134960004	Missense_Mutation	novel	A698T	0.23
CESC	chr7	134933529	Missense_Mutation	NA	H254N	0.23
CESC	chr7	134970462	3'Flank	novel		0.33
CESC	chr7	134933039	Silent	novel	G90G	0.14
CESC	chr7	134933742	Missense_Mutation	novel	A325T	0.3
CESC	chr7	134933978	Missense_Mutation	NA	K403N	0.11
CESC	chr7	134960002	Missense_Mutation	novel	P697L	0.37
CESC	chr7	134947614	Missense_Mutation	novel	E547K	0.4
CESC	chr7	134867698	5'UTR	novel		0.15
CESC	chr7	134933932	Missense_Mutation	rs775880471	R388H	0.18
CHOL	chr7	134947528	Missense_Mutation	novel	S518I	0.08
CHOL	chr7	134947572	Missense_Mutation	rs768053736	G533S	0.12
COAD	chr7	134941184	Silent	rs758682592	S493S	0.36
COAD	chr7	134933193	Missense_Mutation	NA	A142T	0.21
COAD	chr7	134947698	Nonsense_Mutation	novel	R575*	0.11
COAD	chr7	134933088	Missense_Mutation	rs775853439	R107C	0.25
COAD	chr7	134958111	Missense_Mutation	novel	S660R	0.23
COAD	chr7	134960131	Intron	novel		0.34
COAD	chr7	134965321	Missense_Mutation	novel	D771Y	0.25
COAD	chr7	134941199	Missense_Mutation	novel	F498L	0.22
COAD	chr7	134960153	Intron	novel		0.22
COAD	chr7	134867794	Missense_Mutation	NA	E21K	0.16
COAD	chr7	134941199	Missense_Mutation	novel	F498L	0.36
COAD	chr7	134960501	Intron	novel		0.13
COAD	chr7	134958108	Frame_Shift_Del	novel	*S660Afs12**	0.15
COAD	chr7	134960012	Silent	novel	S700S	0.42
COAD	chr7	134947530	Missense_Mutation	rs569578471	V519M	0.18
COAD	chr7	134950507	Missense_Mutation	NA	S643Y	0.29
COAD	chr7	134960153	Intron	novel		0.26
COAD	chr7	134947510	Missense_Mutation	NA	R512H	0.87
COAD	chr7	134928803	Missense_Mutation	rs773676427	R41W	0.36
COAD	chr7	134933365	Missense_Mutation	NA	K199T	0.16
COAD	chr7	134933452	Nonsense_Mutation	novel	L228*	0.08
COAD	chr7	134960198	Intron	novel		0.49
COAD	chr7	134933097	Missense_Mutation	rs372385136	R110C	0.13
COAD	chr7	134928775	Silent	rs746947014	D31D	0.42
COAD	chr7	134933066	Silent	novel	R99R	0.13
COAD	chr7	134947604	Silent	NA	R543R	0.38
COAD	chr7	134958217	Missense_Mutation	NA	V663G	0.22
COAD	chr7	134867734	Translation_Start_Site	NA	M1?	0.37
COAD	chr7	134928872	Missense_Mutation	NA	D64N	0.2
COAD	chr7	134941122	Nonsense_Mutation	NA	E473*	0.26
COAD	chr7	134947752	Nonsense_Mutation	NA	R593*	0.23
COAD	chr7	134928807	Missense_Mutation	rs762365246	R42H	0.5
COAD	chr7	134947752	Nonsense_Mutation	NA	R593*	0.23
COAD	chr7	134933221	Missense_Mutation	NA	E151V	0.16
COAD	chr7	134958223	Missense_Mutation	NA	S665L	0.2
COAD	chr7	134960153	Intron	novel		0.15
COAD	chr7	134928803	Missense_Mutation	rs773676427	R41W	0.26
COAD	chr7	134933118	Missense_Mutation	rs766257245	R117W	0.12
COAD	chr7	134935753	Frame_Shift_Ins	novel	*E461Rfs6**	0.18
ESCA	chr7	134968714	3'UTR	rs539250778		0.48
ESCA	chr7	134968723	3'UTR	novel		0.39
GBM	chr7	134867749	Missense_Mutation	rs748134346	R6C	0.13
GBM	chr7	134965387	Splice_Site	novel	X792_splice	0.02
GBM	chr7	134867753	Missense_Mutation	rs142583902	R7H	0.16
GBM	chr7	134928898	Splice_Region	novel	N72N	0.24
HNSC	chr7	134891589	Intron	rs748990540		0.48
HNSC	chr7	134960245	Intron	novel		0.38
HNSC	chr7	134950433	Silent	novel	K618K	0.33
KICH	chr7	134933043	Missense_Mutation	novel	D92Y	0.36
KICH	chr7	134947686	Frame_Shift_Del	novel	*K571Rfs31**	0.04
KIRC	chr7	134933513	Silent	NA	S248S	0.07
KIRC	chr7	134960490	Intron	novel		0.07
LGG	chr7	134934042	Nonsense_Mutation	novel	E425*	0.17
LGG	chr7	134950434	Missense_Mutation	rs370580506	R619C	0.48
LGG	chr7	134960037	Missense_Mutation	novel	V709I	0.07
LIHC	chr7	134959999	Missense_Mutation	novel	K696T	0.41
LIHC	chr7	134928873	Missense_Mutation	NA	D64V	0.47
LIHC	chr7	134958219	Frame_Shift_Del	novel	*K664Nfs8**	0.15
LIHC	chr7	134968431	3'UTR	novel		0.26
LIHC	chr7	134958282	Missense_Mutation	novel	A685T	0.05
LUAD	chr7	134947513	Missense_Mutation	novel	P513R	0.33
LUAD	chr7	134941171	Missense_Mutation	NA	T489K	0.16
LUAD	chr7	134933067	Missense_Mutation	NA	L100M	0.24
LUAD	chr7	134928819	Missense_Mutation	novel	R46L	0.09
LUAD	chr7	134960607	Silent	novel	K758K	0.21
LUAD	chr7	134958256	Missense_Mutation	novel	D676G	0.09
LUAD	chr7	134960083	Frame_Shift_Del	novel	*T726Lfs13**	0.67
LUAD	chr7	134933592	Missense_Mutation	novel	E275K	0.1
LUAD	chr7	134933475	Missense_Mutation	NA	E236K	0.11
LUAD	chr7	134867731	5'UTR	novel		0.19
LUAD	chr7	134968409	3'UTR	novel		0.09
LUAD	chr7	134928804	Missense_Mutation	rs774839540	R41Q	0.22
LUAD	chr7	134933205	Missense_Mutation	NA	T146A	0.31
LUAD	chr7	134950505	Silent	novel	S642S	0.31
LUAD	chr7	134960135	Intron	novel		0.42
LUAD	chr7	134933089	Missense_Mutation	NA	R107L	0.13
LUAD	chr7	134960715	Intron	novel		0.25
LUAD	chr7	134867751	Silent	NA	R6R	0.41
LUAD	chr7	134891545	Intron	novel		0.33
LUAD	chr7	134947740	Missense_Mutation	NA	E589Q	0.23
LUAD	chr7	134867715	5'UTR	NA		0.15
LUSC	chr7	134965380	Silent	novel	P790P	0.08
LUSC	chr7	134941145	Silent	novel	S480S	0.44
LUSC	chr7	134933182	Missense_Mutation	NA	Q138R	0.49
LUSC	chr7	134933073	Silent	NA	R102R	0.1
LUSC	chr7	134958075	Missense_Mutation	novel	E648Q	0.26
LUSC	chr7	134928798	Missense_Mutation	novel	R39L	0.23
LUSC	chr7	134958247	Missense_Mutation	novel	S673C	0.04
LUSC	chr7	134933061	Nonsense_Mutation	novel	E98*	0.27
LUSC	chr7	134958258	Missense_Mutation	NA	S677R	0.15
OV	chr7	134965371	Silent	novel	V787V	0.03
OV	chr7	134960632	Splice_Region	novel		0.27
OV	chr7	134928771	Missense_Mutation	novel	N30T	0.11
PAAD	chr7	134960514	Intron	novel		0.2
PAAD	chr7	134950410	Nonsense_Mutation	NA	R611*	0.04
PAAD	chr7	134928776	Missense_Mutation	novel	D32N	0.09
PRAD	chr7	134960241	Intron	novel		0.29
READ	chr7	134941183	Missense_Mutation	rs201681214	S493L	0.31
READ	chr7	134947628	Silent	rs757030162	F551F	0.11
READ	chr7	134933226	Frame_Shift_Ins	NA	*S153Rfs2**	0.32
READ	chr7	134928833	Missense_Mutation	NA	R51W	0.37
READ	chr7	134928901	Splice_Site	NA	X73_splice	0.34
READ	chr7	134933104	Missense_Mutation	NA	Q112R	0.31
READ	chr7	134941148	Missense_Mutation	novel	F481L	0.05
READ	chr7	134960106	Missense_Mutation	NA	N732H	0.26
READ	chr7	134934071	Silent	NA	K434K	0.39
READ	chr7	134947628	Silent	rs757030162	F551F	0.41
READ	chr7	134933951	Frame_Shift_Ins	NA	*H397Tfs24**	0.26
SARC	chr7	134947555	Frame_Shift_Del	NA	*Q529Rfs76**	0.34
SARC	chr7	134947706	Missense_Mutation	rs773589171	K577N	0.51
SKCM	chr7	134960710	Intron	novel		0.38
SKCM	chr7	134933237	Silent	novel	R156R	0.31
SKCM	chr7	134933238	Nonsense_Mutation	novel	Q157*	0.31
SKCM	chr7	134960479	Intron	novel		0.94
SKCM	chr7	134947620	Missense_Mutation	NA	E549K	0.19
SKCM	chr7	134960475	Intron	NA		0.4
SKCM	chr7	134960524	Intron	novel		0.21
SKCM	chr7	134941199	Silent	NA	F498F	0.57
SKCM	chr7	134941155	Nonsense_Mutation	NA	R484*	0.3
SKCM	chr7	134928871	Silent	NA	T63T	0.39
SKCM	chr7	134947512	Missense_Mutation	NA	P513S	0.55
SKCM	chr7	134959980	Missense_Mutation	NA	K690E	0.59
SKCM	chr7	134933524	Missense_Mutation	novel	S252F	0.25
SKCM	chr7	134968360	3'UTR	novel		0.32
SKCM	chr7	134950507	Missense_Mutation	novel	S643F	0.54
SKCM	chr7	134960674	Intron	novel		0.81
SKCM	chr7	134933452	Missense_Mutation	NA	L228S	0.38
STAD	chr7	134947724	Silent	novel	E583E	0.5
STAD	chr7	134933554	Missense_Mutation	novel	K262T	0.36
STAD	chr7	134960153	Intron	novel		0.31
STAD	chr7	134947748	Silent	rs758658636	A591A	0.18
STAD	chr7	134867744	Missense_Mutation	NA	F4C	0.45
STAD	chr7	134928806	Missense_Mutation	NA	R42C	0.49
STAD	chr7	134933336	Missense_Mutation	NA	E189D	0.32
STAD	chr7	134960734	Intron	novel		0.56
STAD	chr7	134960152	Intron	NA		0.2
STAD	chr7	134891552	Intron	novel		0.4
STAD	chr7	134933088	Missense_Mutation	rs775853439	R107C	0.23
STAD	chr7	134950409	Silent	rs751734611	R610R	0.25
STAD	chr7	134933283	Missense_Mutation	novel	Y172H	0.3
STAD	chr7	134933967	Nonsense_Mutation	NA	Q400*	0.08
STAD	chr7	134958251	Missense_Mutation	NA	K674N	0.15
STAD	chr7	134960153	Intron	novel		0.31
STAD	chr7	134867750	Missense_Mutation	rs772216381	R6H	0.38
STAD	chr7	134947602	Missense_Mutation	NA	R543C	0.38
STAD	chr7	134891665	Intron	novel		0.17
STAD	chr7	134947657	Missense_Mutation	rs769729218	A561V	0.44
THCA	chr7	134960157	Intron	novel		0.12
THCA	chr7	134891601	Intron	novel		0.1
THCA	chr7	134933199	Frame_Shift_Ins	novel	*N144Rfs3**	0.14
THYM	chr7	134891495	Intron	novel		0.21
THYM	chr7	134947687	Missense_Mutation	novel	K571R	0.09
UCEC	chr7	134960153	Intron	novel		0.1
UCEC	chr7	134867794	Missense_Mutation	NA	E21K	0.31
UCEC	chr7	134933695	Missense_Mutation	NA	R309I	0.33
UCEC	chr7	134941226	Missense_Mutation	NA	E507D	0.24
UCEC	chr7	134928802	Silent	NA	E40E	0.27
UCEC	chr7	134960080	Nonsense_Mutation	NA	S723*	0.37
UCEC	chr7	134933372	Silent	novel	G201G	0.47
UCEC	chr7	134969776	3'Flank	novel		0.31
UCEC	chr7	134941160	Missense_Mutation	NA	K485N	0.37
UCEC	chr7	134960843	Intron	novel		0.3
UCEC	chr7	134928864	Missense_Mutation	NA	Q61R	0.32
UCEC	chr7	134933981	Frame_Shift_Del	novel	*E407Kfs3**	0.5
UCEC	chr7	134970476	3'Flank	novel		0.52
UCEC	chr7	134968755	3'UTR	novel		0.14
UCEC	chr7	134933064	Missense_Mutation	rs778481089	R99C	0.4
UCEC	chr7	134947528	Missense_Mutation	novel	S518I	0.42
UCEC	chr7	134947529	Silent	novel	S518S	0.41
UCEC	chr7	134933758	Missense_Mutation	NA	R330M	0.27
UCEC	chr7	134933076	Missense_Mutation	rs369898278	R103C	0.16
UCEC	chr7	134933432	Silent	novel	E221E	0.03
UCEC	chr7	134933590	Missense_Mutation	novel	A274E	0.17
UCEC	chr7	134933973	Missense_Mutation	rs201623086	T402A	0.21
UCEC	chr7	134928797	Missense_Mutation	rs775030605	R39W	0.31
UCEC	chr7	134958078	Nonsense_Mutation	NA	R649*	0.47
UCEC	chr7	134960493	Intron	novel		0.46
UCEC	chr7	134934071	Missense_Mutation	novel	K434N	0.46
UCEC	chr7	134969095	3'UTR	novel		0.14
UCEC	chr7	134960012	Silent	novel	S700S	0.33
UCEC	chr7	134947554	Frame_Shift_Ins	novel	*Q529Pfs81**	0.43
UCEC	chr7	134947555	Frame_Shift_Del	NA	*Q529Rfs76**	0.26
UCEC	chr7	134935756	Missense_Mutation	novel	K459N	0.18
UCEC	chr7	134941122	Nonsense_Mutation	NA	E473*	0.15
UCEC	chr7	134867753	Missense_Mutation	rs142583902	R7H	0.32
UCEC	chr7	134950472	Missense_Mutation	novel	K631N	0.64
UCEC	chr7	134941106	Missense_Mutation	NA	K467N	0.37
UCEC	chr7	134941238	Splice_Site	NA	X511_splice	0.42
UCEC	chr7	134941131	Nonsense_Mutation	novel	E476*	0.36
UCEC	chr7	134969141	3'UTR	novel		0.33
UCEC	chr7	134970626	3'Flank	novel		0.45
UCEC	chr7	134960209	Intron	novel		0.34
UCEC	chr7	134968713	3'UTR	novel		0.28
UCEC	chr7	134969075	3'UTR	novel		0.32
UCEC	chr7	134969929	3'Flank	rs771216573		0.29
UCEC	chr7	134965337	Missense_Mutation	rs571684749	R776Q	0.16
UCEC	chr7	134947555	Frame_Shift_Del	NA	*Q529Rfs76**	0.38
UCEC	chr7	134935701	Missense_Mutation	novel	G441V	0.4
UCEC	chr7	134891459	Intron	novel		0.38
UCEC	chr7	134933946	Nonsense_Mutation	novel	E393*	0.31
UCEC	chr7	134960616	Silent	novel	A761A	0.46
UCEC	chr7	134960153	Intron	novel		0.37
UCEC	chr7	134970608	3'Flank	novel		0.43
UCEC	chr7	134968714	3'UTR	rs539250778		0.25
UCEC	chr7	134970619	3'Flank	novel		0.47
UCEC	chr7	134933774	Missense_Mutation	NA	E335D	0.24
UCEC	chr7	134933932	Missense_Mutation	rs775880471	R388H	0.3
UCEC	chr7	134941091	Splice_Site	NA	X463_splice	0.29
UCEC	chr7	134960836	Intron	novel		0.39
UCEC	chr7	134950480	Missense_Mutation	novel	F634C	0.32
UCEC	chr7	134933144	Missense_Mutation	novel	I125M	0.27
UCEC	chr7	134965324	Missense_Mutation	rs147498390	V772I	0.46
UCEC	chr7	134947646	Silent	novel	K557K	0.09
UCEC	chr7	134933061	Missense_Mutation	novel	E98K	0.09
UCEC	chr7	134950379	Missense_Mutation	NA	E600D	0.43
UCEC	chr7	134958092	Missense_Mutation	novel	L653F	0.25
UCEC	chr7	134960449	Intron	novel		0.33
UCEC	chr7	134928813	Missense_Mutation	rs144711541	R44Q	0.11
UCEC	chr7	134933931	Missense_Mutation	rs201179218	R388C	0.44
UCEC	chr7	134947511	Silent	novel	R512R	0.6
UCEC	chr7	134867793	Silent	rs767141301	L20L	0.4
UCEC	chr7	134970645	3'Flank	novel		0.55
UCEC	chr7	134947596	Missense_Mutation	NA	R541C	0.33
UCEC	chr7	134933347	Missense_Mutation	novel	E193G	0.19
UCEC	chr7	134960124	Intron	novel		0.28
UCEC	chr7	134947613	Silent	novel	T546T	0.41
UCEC	chr7	134867794	Missense_Mutation	NA	E21K	0.37
UCEC	chr7	134928813	Missense_Mutation	rs144711541	R44Q	0.38
UCEC	chr7	134947619	Silent	novel	S548S	0.41
UCEC	chr7	134960627	Missense_Mutation	novel	S765Y	0.55
UCEC	chr7	134947565	Silent	novel	V530V	0.44
UVM	chr7	134935741	Silent	novel	D454D	0.48

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0667	0.12261
CESC	DEL	0.1763	0.0016147
DLBC	DEL	0.0833	0.03486
KIRC	AMP	0.2822	0.075418
LAML	DEL	0.1204	3.4101e-05
LGG	AMP	0.3119	1.5525e-07
LIHC	DEL	0.0703	0.24831
PAAD	DEL	0.0598	0.049388
TGCT	DEL	0.0667	0.11738
THCA	DEL	0	0.27619
UCEC	DEL	0.0928	0.0001859
UCS	DEL	0.3036	0.10142

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00018	Kaplan-Meier Survival Analysis
STAD	0.0062	Kaplan-Meier Survival Analysis
SARC	0.038	Kaplan-Meier Survival Analysis
MESO	0.0074	Kaplan-Meier Survival Analysis
ACC	0.035	Kaplan-Meier Survival Analysis
SKCM	0.015	Kaplan-Meier Survival Analysis
LUSC	0.024	Kaplan-Meier Survival Analysis
KIRP	0.022	Kaplan-Meier Survival Analysis
BLCA	0.00089	Kaplan-Meier Survival Analysis
CESC	0.012	Kaplan-Meier Survival Analysis
UCEC	0.026	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000122786 (Gene tree)
Gene ID: 800
Gene Symbol: CALD1
Alias: CDM|H-CAD|L-CAD
Full Name: caldesmon 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 226,478 bases
Position: chr7:134,744,252-134,970,729
Accession: 1441
RBP type: non-canonical RBP
Summary: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000445569	CALD1-211	525	-	ENSP00000390926	132 (aa)	-	C9JEK3
ENST00000436461	CALD1-209	1614	-	ENSP00000411476	459 (aa)	-	C9J813
ENST00000473714	CALD1-216	230	-	-	- (aa)	-	-
ENST00000482470	CALD1-220	3941	-	-	- (aa)	-	-
ENST00000435928	CALD1-208	458	-	ENSP00000416611	72 (aa)	-	C9JE79
ENST00000478075	CALD1-218	193	-	-	- (aa)	-	-
ENST00000495522	CALD1-222	2199	-	ENSP00000419673	557 (aa)	-	E7EX44
ENST00000466704	CALD1-214	903	-	-	- (aa)	-	-
ENST00000462181	CALD1-213	188	-	-	- (aa)	-	-
ENST00000489019	CALD1-221	422	-	-	- (aa)	-	-
ENST00000443197	CALD1-210	4173	-	ENSP00000407522	536 (aa)	-	E9PGZ1
ENST00000454108	CALD1-212	558	-	ENSP00000401988	72 (aa)	-	C9JE79
ENST00000480638	CALD1-219	560	-	-	- (aa)	-	-
ENST00000496024	CALD1-223	557	-	-	- (aa)	-	-
ENST00000424922	CALD1-206	2124	XM_017012654	ENSP00000393621	532 (aa)	XP_016868143	Q05682
ENST00000430085	CALD1-207	1938	-	ENSP00000394715	85 (aa)	-	F8WE61
ENST00000498254	CALD1-224	443	-	-	- (aa)	-	-
ENST00000472096	CALD1-215	651	-	-	- (aa)	-	-
ENST00000417172	CALD1-204	1915	-	ENSP00000398826	538 (aa)	-	Q05682
ENST00000393118	CALD1-203	4281	-	ENSP00000376826	558 (aa)	-	Q05682
ENST00000361901	CALD1-202	4114	XM_017012652	ENSP00000354513	538 (aa)	XP_016868141	Q05682
ENST00000422748	CALD1-205	2665	XM_024446942	ENSP00000395710	563 (aa)	XP_024302710	Q05682
ENST00000475772	CALD1-217	753	-	-	- (aa)	-	-
ENST00000361675	CALD1-201	3612	XM_017012650	ENSP00000354826	793 (aa)	XP_016868139	Q05682

Gene Model

Click here to download ENSG00000122786's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04270	Vascular smooth muscle contraction	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000122786	Leukocyte Count	7.4410000E-005	-
ENSG00000122786	Platelet Function Tests	1.7253200E-005	-
ENSG00000122786	Platelet Function Tests	1.5351200E-005	-
ENSG00000122786	Paliperidone Palmitate	5E-6	27846195
ENSG00000122786	Schizophrenia	5E-6	27846195
ENSG00000122786	Paliperidone Palmitate	5E-6	27846195
ENSG00000122786	Schizophrenia	5E-6	27846195
ENSG00000122786	Peripheral Nervous System Diseases	6E-6	24554482
ENSG00000122786	HIV-1	6E-6	24554482
ENSG00000122786	Reverse Transcriptase Inhibitors	6E-6	24554482
ENSG00000122786	Attention Deficit Disorder with Hyperactivity	2E-6	27663945

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000122786	rs10247392	7	134883505	?	Response to paliperidone in schizophrenia (PANSS score)	27846195	[0.097-0.242] unit decrease	0.1695217	EFO_0000692\|EFO_0007925\|EFO_0007927
ENSG00000122786	rs10247392	7	134883505	G	Response to paliperidone in schizophrenia (PANSS score)	27846195	[NR] unit increase	2.9047	EFO_0000692\|EFO_0007925\|EFO_0007927
ENSG00000122786	rs79846815	7	134878819	A	Attention deficit hyperactivity disorder symptom score	27663945			EFO_0007860
ENSG00000122786	rs17169635	7	134805711	?	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy)	24554482	[NR]	3.526	GO_0061479\|EFO_0000180\|EFO_0003100
ENSG00000122786	rs2003620	7	134794733	C	Hepatocyte growth factor levels	27989323	[0.13-0.32] SD units decrease	0.2279	EFO_0006903
ENSG00000122786	rs28674970	7	134874329	T	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.14-0.36] unit increase	0.249546	EFO_0008377\|EFO_0008378
ENSG00000122786	rs13247106	7	134874629	G	Diverticular disease	30177863	[NR] unit decrease	0.0031645	EFO_1001460
ENSG00000122786	rs1452909	7	134881320	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122786's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000122786	CALD1	100	95.833	ENSMUSG00000029761	Cald1	98	92.812	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005523	tropomyosin binding	1555769.	TAS	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006936	muscle contraction	-	TAS	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0017022	myosin binding	-	IEA	Function
GO:0030016	myofibril	-	IEA	Component
GO:0030478	actin cap	-	IEA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.