EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26464646	Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.	Int J Clin Exp Pathol	2015 Aug 1	Jiang Y	-
10473113	A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.	Clin Cancer Res	1999 Aug	Kassis J	-
18037957	Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion.	Oncogene	2008 May 1	Peak JC	-
22554284	Akt and phospholipase Cγ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin.	BMC Res Notes	2012 Jul 10	Tomas NM	doi: 10.1186/1756-0500-5-214.
20514023	miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer.	Oncogene	2010 Jul 29	Uhlmann S	doi: 10.1038/onc.2010.201
25456276	Dysfunction of phospholipase Cγ in immune disorders and cancer.	Trends Biochem Sci	2014 Dec	Koss H	doi: 10.1016/j.tibs.2014.09.004
21087080	Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells.	Scand J Clin Lab Invest	2011 Feb	Memon AA	doi: 10.3109/00365513.2010.536250
21986528	PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer.	Biochem Biophys Res Commun	2011 Oct 28	Cho HJ	doi: 10.1016/j.bbrc.2011.09.121
15996687	NF-kappaB and Hsp70 are involved in the phospholipase Cgamma1 signaling pathway in colorectal cancer cells.	Life Sci	2005 Oct 14	Li X	-
22262199	The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-γ1 signalling in breast cancer cell migration and dissemination.	J Pathol	2012 Jun	Balz LM	doi: 10.1002/path.3991
19074886	Phospholipase Cgamma1 is required for metastasis development and progression.	Cancer Res	2008 Dec 15	Sala G	doi: 10.1158/0008-5472.CAN-08-1181.
28112359	Expression of phospholipase C isozymes in human breast cancer and their clinical significance.	Oncol Rep	2017 Mar	Cai S	doi: 10.3892/or.2017.5394

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr20	41166384	Missense_Mutation	novel	E664K	0.46
ACC	chr20	41165509	Silent	novel	T523T	0.44
ACC	chr20	41165039	Missense_Mutation	rs761490511	V442M	0.45
BLCA	chr20	41165792	Missense_Mutation	NA	E589K	0.67
BLCA	chr20	41174181	Missense_Mutation	NA	D1234H	0.12
BLCA	chr20	41167896	Missense_Mutation	novel	F782L	0.13
BLCA	chr20	41164145	Missense_Mutation	novel	K387N	0.46
BLCA	chr20	41165310	Silent	rs150914278	N484N	0.32
BLCA	chr20	41166556	Missense_Mutation	novel	R694Q	0.25
BLCA	chr20	41173521	Missense_Mutation	novel	K1127N	0.46
BLCA	chr20	41166857	Missense_Mutation	novel	A767P	0.09
BLCA	chr20	41165002	Missense_Mutation	novel	F429L	0.15
BLCA	chr20	41168812	Missense_Mutation	NA	E809K	0.52
BLCA	chr20	41159916	Nonsense_Mutation	novel	W139*	0.09
BLCA	chr20	41170236	Silent	rs149943087	K925K	0.25
BLCA	chr20	41173714	Missense_Mutation	NA	E1153K	0.29
BLCA	chr20	41165524	Silent	novel	G528G	0.12
BLCA	chr20	41174253	Missense_Mutation	novel	E1258K	0.04
BLCA	chr20	41170198	Missense_Mutation	NA	A913T	0.19
BRCA	chr20	41174661	3'UTR	novel		0.09
BRCA	chr20	41167850	Splice_Site	NA	X768_splice	0.38
BRCA	chr20	41165295	Missense_Mutation	NA	M479I	0.16
BRCA	chr20	41165039	Missense_Mutation	rs761490511	V442M	0.07
BRCA	chr20	41170169	Missense_Mutation	rs200504048	S903L	0.2
BRCA	chr20	41172243	Silent	NA	L953L	0.12
BRCA	chr20	41174519	3'UTR	novel		0.21
BRCA	chr20	41162491	Silent	NA	V184V	0.36
BRCA	chr20	41166784	Silent	NA	E742E	0.4
BRCA	chr20	41162697	Missense_Mutation	NA	R218H	0.19
BRCA	chr20	41173498	Missense_Mutation	NA	E1120K	0.11
BRCA	chr20	41164096	Missense_Mutation	novel	G371D	0.09
BRCA	chr20	41174208	Nonsense_Mutation	rs756437887	R1243*	0.25
BRCA	chr20	41169524	Missense_Mutation	NA	I883N	0.24
BRCA	chr20	41170235	Missense_Mutation	novel	K925R	0.13
BRCA	chr20	41174236	Missense_Mutation	rs565097087	R1252H	0.31
CESC	chr20	41165818	Silent	rs555840839	L597L	0.17
CESC	chr20	41166793	Silent	novel	P745P	0.32
CESC	chr20	41165728	Silent	NA	R567R	0.33
CESC	chr20	41166561	Missense_Mutation	rs764393595	R696W	0.21
CESC	chr20	41175161	3'UTR	novel		0.25
CESC	chr20	41166342	Missense_Mutation	NA	E650Q	0.34
CESC	chr20	41166561	Missense_Mutation	rs764393595	R696W	0.33
CESC	chr20	41167913	Missense_Mutation	novel	P788H	0.33
CESC	chr20	41173496	Missense_Mutation	novel	A1119V	0.2
CESC	chr20	41174823	3'UTR	novel		0.22
CESC	chr20	41165316	Missense_Mutation	NA	I486M	0.29
CESC	chr20	41166510	Missense_Mutation	novel	E679K	0.08
CHOL	chr20	41165335	Missense_Mutation	novel	G493S	0.1
COAD	chr20	41137749	Frame_Shift_Del	novel	*L37Vfs37**	0.22
COAD	chr20	41174304	Missense_Mutation	NA	E1275K	0.13
COAD	chr20	41162986	Missense_Mutation	novel	T237I	0.29
COAD	chr20	41169474	Frame_Shift_Del	novel	L868*	0.36
COAD	chr20	41159687	Missense_Mutation	NA	R100Q	0.25
COAD	chr20	41166595	Missense_Mutation	NA	R707Q	0.26
COAD	chr20	41163966	Silent	NA	A352A	0.23
COAD	chr20	41166508	Missense_Mutation	NA	A678V	0.53
COAD	chr20	41169494	Missense_Mutation	novel	R873Q	0.37
COAD	chr20	41174593	3'UTR	novel		0.82
COAD	chr20	41163781	Missense_Mutation	rs780274359	D320N	0.44
COAD	chr20	41172466	Missense_Mutation	NA	P984L	0.07
COAD	chr20	41170253	Missense_Mutation	NA	Q931L	0.39
COAD	chr20	41173931	Missense_Mutation	NA	A1189T	0.3
COAD	chr20	41168799	Silent	rs137975099	A804A	0.18
COAD	chr20	41174214	Missense_Mutation	novel	R1245W	0.17
COAD	chr20	41166587	Silent	NA	I704I	0.29
COAD	chr20	41172523	Missense_Mutation	NA	Y1003S	0.32
COAD	chr20	41172766	Silent	rs766145575	T1056T	0.32
COAD	chr20	41174576	3'UTR	novel		0.12
COAD	chr20	41172584	Silent	novel	Y1023Y	0.38
COAD	chr20	41159633	Missense_Mutation	NA	R82H	0.14
DLBC	chr20	41165669	Missense_Mutation	novel	E548K	0.16
ESCA	chr20	41170169	Missense_Mutation	rs200504048	S903L	0.2
ESCA	chr20	41172281	Frame_Shift_Ins	novel	*D966Efs2**	0.14
ESCA	chr20	41160137	Missense_Mutation	NA	R166W	0.09
ESCA	chr20	41166328	Missense_Mutation	rs756135063	R645H	0.51
ESCA	chr20	41173454	Missense_Mutation	novel	R1105Q	0.46
GBM	chr20	41159720	Missense_Mutation	rs766543085	Y111C	0.45
GBM	chr20	41169158	Frame_Shift_Ins	novel	*L855Qfs15**	0.08
GBM	chr20	41169153	Frame_Shift_Del	novel	*V853Gfs16**	0.15
GBM	chr20	41172529	Missense_Mutation	rs768105603	R1005Q	0.2
GBM	chr20	41170146	Silent	NA	F895F	0.18
GBM	chr20	41172258	Silent	novel	V958V	0.2
GBM	chr20	41173744	Missense_Mutation	NA	E1163K	0.38
GBM	chr20	41165072	Missense_Mutation	novel	N453D	0.17
GBM	chr20	41173458	Silent	novel	G1106G	0.11
HNSC	chr20	41163243	Missense_Mutation	novel	E253Q	0.15
HNSC	chr20	41163445	Missense_Mutation	novel	R286L	0.22
HNSC	chr20	41168812	Missense_Mutation	novel	E809Q	0.24
HNSC	chr20	41163267	Missense_Mutation	rs758702634	Y261H	0.24
HNSC	chr20	41166290	Silent	novel	L632L	0.2
HNSC	chr20	41159754	Silent	novel	L122L	0.12
HNSC	chr20	41172577	Missense_Mutation	novel	S1021C	0.2
HNSC	chr20	41164983	Missense_Mutation	novel	R423K	0.21
HNSC	chr20	41169152	Missense_Mutation	rs753634028	V853M	0.4
HNSC	chr20	41159662	Missense_Mutation	novel	R92G	0.21
HNSC	chr20	41165057	Missense_Mutation	novel	G448R	0.3
KICH	chr20	41172445	Missense_Mutation	novel	Y977C	0.1
KIRC	chr20	41170200	Silent	NA	A913A	0.14
KIRC	chr20	41173464	Silent	NA	V1108V	0.38
KIRC	chr20	41167866	Silent	NA	G772G	0.24
KIRP	chr20	41166213	Frame_Shift_Del	novel	*H607Lfs23**	0.32
LAML	chr20	41165315	Missense_Mutation	novel	I486S	0.1
LAML	chr20	41166583	Missense_Mutation	novel	A703V	0.13
LGG	chr20	41173744	Missense_Mutation	NA	E1163K	0.31
LGG	chr20	41173746	In_Frame_Ins	novel	E1163_E1164dup	0.33
LGG	chr20	41165274	Silent	rs780171437	Y472Y	0.19
LGG	chr20	41167875	Silent	novel	Y775Y	0.39
LGG	chr20	41166819	Missense_Mutation	NA	Y754C	0.4
LGG	chr20	41173744	Missense_Mutation	NA	E1163K	0.11
LIHC	chr20	41173522	Missense_Mutation	NA	T1128A	0.07
LIHC	chr20	41163810	Frame_Shift_Ins	novel	*W330Lfs18**	0.4
LIHC	chr20	41174140	Missense_Mutation	novel	L1220R	0.47
LIHC	chr20	41163800	Missense_Mutation	NA	L326P	0.49
LIHC	chr20	41162466	Missense_Mutation	novel	D176V	0.29
LUAD	chr20	41166589	Missense_Mutation	NA	S705C	0.06
LUAD	chr20	41165752	Missense_Mutation	NA	E575D	0.5
LUAD	chr20	41163944	Missense_Mutation	NA	S345F	0.06
LUAD	chr20	41163945	Silent	NA	S345S	0.06
LUAD	chr20	41162449	Splice_Region	novel		0.09
LUAD	chr20	41166509	Silent	novel	A678A	0.16
LUAD	chr20	41165537	Missense_Mutation	NA	E533K	0.27
LUAD	chr20	41163779	Missense_Mutation	rs150381500	P319R	0.17
LUAD	chr20	41162535	Missense_Mutation	novel	T199K	0.62
LUAD	chr20	41165343	Silent	rs375923457	L495L	0.49
LUAD	chr20	41172544	Missense_Mutation	NA	R1010L	0.13
LUSC	chr20	41163231	Missense_Mutation	NA	V249M	0.26
LUSC	chr20	41173530	Silent	NA	F1130F	0.21
LUSC	chr20	41165792	Missense_Mutation	NA	E589Q	0.13
LUSC	chr20	41174150	Silent	NA	F1223F	0.58
LUSC	chr20	41164188	Frame_Shift_Del	novel	*F402Lfs78**	0.37
LUSC	chr20	41164106	Silent	novel	G374G	0.17
OV	chr20	41165749	Missense_Mutation	rs146548575	I574M	0.16
OV	chr20	41166589	Missense_Mutation	NA	S705C	0.13
OV	chr20	41162655	Missense_Mutation	rs764899653	R204H	0.32
OV	chr20	41174261	Silent	rs200825598	F1260F	0.07
OV	chr20	41163719	Missense_Mutation	novel	V299D	0.34
PAAD	chr20	41173931	Missense_Mutation	NA	A1189T	0.18
PRAD	chr20	41167882	Missense_Mutation	rs767507889	R778C	0.24
READ	chr20	41166705	Missense_Mutation	NA	R716H	0.37
READ	chr20	41159696	Missense_Mutation	novel	Q103L	0.06
READ	chr20	41166751	Silent	rs778521353	F731F	0.46
SARC	chr20	41163834	Splice_Site	novel	X337_splice	0.55
SARC	chr20	41169093	Missense_Mutation	novel	Y833C	0.07
SARC	chr20	41165308	Missense_Mutation	novel	N484Y	0.12
SARC	chr20	41163973	Missense_Mutation	rs201158224	R355C	0.44
SKCM	chr20	41165779	Silent	rs149803392	L584L	0.27
SKCM	chr20	41165749	Silent	rs146548575	I574I	0.4
SKCM	chr20	41163471	Silent	NA	L295L	0.3
SKCM	chr20	41170400	Intron	novel		0.43
SKCM	chr20	41160152	Missense_Mutation	NA	R171C	0.25
SKCM	chr20	41163428	Silent	rs200581225	F280F	0.1
SKCM	chr20	41163396	Missense_Mutation	NA	R270C	0.28
SKCM	chr20	41164945	Silent	NA	I410I	0.37
SKCM	chr20	41163452	Silent	rs751778690	I288I	0.22
SKCM	chr20	41163257	Silent	NA	F257F	0.43
SKCM	chr20	41165062	Silent	NA	L449L	0.54
SKCM	chr20	41164113	Missense_Mutation	novel	V377I	0.35
SKCM	chr20	41172460	Missense_Mutation	NA	S982F	0.25
SKCM	chr20	41166295	Missense_Mutation	NA	D634G	0.41
SKCM	chr20	41172447	Missense_Mutation	rs755375534	R978W	0.23
SKCM	chr20	41166704	Missense_Mutation	rs750533169	R716C	0.43
SKCM	chr20	41172515	Silent	NA	F1000F	0.43
STAD	chr20	41163267	Missense_Mutation	rs758702634	Y261H	0.15
STAD	chr20	41172198	Silent	NA	T938T	0.28
STAD	chr20	41170264	Missense_Mutation	NA	A935T	0.39
STAD	chr20	41159651	Missense_Mutation	novel	R88Q	0.34
STAD	chr20	41165702	Missense_Mutation	NA	R559C	0.18
STAD	chr20	41172607	Missense_Mutation	NA	C1031Y	0.41
STAD	chr20	41165518	Silent	novel	D526D	0.45
STAD	chr20	41160143	Missense_Mutation	rs774118487	R168C	0.23
STAD	chr20	41170264	Missense_Mutation	NA	A935T	0.18
STAD	chr20	41163433	Missense_Mutation	rs769806657	R282Q	0.18
STAD	chr20	41165068	Silent	NA	S451S	0.39
STAD	chr20	41166220	Missense_Mutation	rs747210988	R609H	0.34
STAD	chr20	41166567	Nonsense_Mutation	novel	E698*	0.5
STAD	chr20	41170147	Missense_Mutation	rs146143589	V896I	0.36
STAD	chr20	41163396	Missense_Mutation	NA	R270C	0.19
STAD	chr20	41170166	Missense_Mutation	rs140033921	A902V	0.12
STAD	chr20	41160114	Missense_Mutation	rs777319797	R158Q	0.44
STAD	chr20	41165034	Missense_Mutation	NA	K440R	0.1
STAD	chr20	41172647	Splice_Site	NA	X1044_splice	0.5
STAD	chr20	41164099	Missense_Mutation	rs759833563	P372L	0.13
STAD	chr20	41162713	Silent	NA	S223S	0.29
STAD	chr20	41164166	Silent	NA	L394L	0.23
STAD	chr20	41162724	Missense_Mutation	rs141297485	T227M	0.19
STAD	chr20	41160135	Missense_Mutation	NA	D165V	0.22
STAD	chr20	41164109	Missense_Mutation	NA	M375I	0.32
STAD	chr20	41166279	Missense_Mutation	NA	F629V	0.11
STAD	chr20	41162654	Missense_Mutation	rs756870964	R204C	0.25
STAD	chr20	41166561	Missense_Mutation	rs764393595	R696W	0.34
STAD	chr20	41168799	Silent	novel	A804A	0.26
STAD	chr20	41170264	Missense_Mutation	NA	A935T	0.28
THCA	chr20	41172544	Missense_Mutation	NA	R1010H	0.1
THYM	chr20	41166857	Missense_Mutation	novel	A767S	0.24
UCEC	chr20	41166224	Silent	novel	I610I	0.23
UCEC	chr20	41166751	Silent	rs778521353	F731F	0.37
UCEC	chr20	41170335	Intron	novel		0.28
UCEC	chr20	41173718	Missense_Mutation	NA	F1154C	0.38
UCEC	chr20	41162655	Missense_Mutation	rs764899653	R204H	0.23
UCEC	chr20	41166705	Missense_Mutation	NA	R716H	0.11
UCEC	chr20	41170193	Missense_Mutation	novel	V911A	0.07
UCEC	chr20	41166751	Silent	rs778521353	F731F	0.06
UCEC	chr20	41170146	Silent	NA	F895F	0.29
UCEC	chr20	41174302	Missense_Mutation	rs372257814	R1274Q	0.38
UCEC	chr20	41168784	Silent	novel	L799L	0.29
UCEC	chr20	41164095	Missense_Mutation	NA	G371S	0.43
UCEC	chr20	41174249	Silent	rs374152526	P1256P	0.35
UCEC	chr20	41159632	Missense_Mutation	rs773797758	R82C	0.47
UCEC	chr20	41175156	3'UTR	novel		0.25
UCEC	chr20	41174307	Nonsense_Mutation	novel	R1276*	0.34
UCEC	chr20	41168832	Silent	novel	S815S	0.26
UCEC	chr20	41174566	3'UTR	rs370567797		0.42
UCEC	chr20	41163429	Missense_Mutation	NA	L281I	0.2
UCEC	chr20	41165662	Silent	rs775474675	H545H	0.29
UCEC	chr20	41165814	Missense_Mutation	NA	T596M	0.23
UCEC	chr20	41166527	Silent	rs377147698	R684R	0.12
UCEC	chr20	41173495	Missense_Mutation	novel	A1119S	0.06
UCEC	chr20	41170487	Intron	novel		0.12
UCEC	chr20	41174311	Missense_Mutation	NA	R1277K	0.45
UCEC	chr20	41172548	Missense_Mutation	NA	I1011M	0.4
UCEC	chr20	41174576	3'UTR	novel		0.35
UCEC	chr20	41173804	Missense_Mutation	novel	L1183M	0.34
UCEC	chr20	41170263	Silent	rs34183705	D934D	0.26
UCEC	chr20	41162528	Missense_Mutation	rs370628843	R197W	0.31
UCEC	chr20	41163445	Missense_Mutation	NA	R286Q	0.25
UCEC	chr20	41165711	Missense_Mutation	novel	R562C	0.32
UCEC	chr20	41165712	Missense_Mutation	novel	R562H	0.32
UCEC	chr20	41166751	Silent	rs778521353	F731F	0.36
UCEC	chr20	41174739	3'UTR	novel		0.23
UCEC	chr20	41174880	3'UTR	novel		0.41
UCEC	chr20	41174721	3'UTR	novel		0.26
UCEC	chr20	41163774	Silent	novel	V317V	0.28
UCEC	chr20	41162966	Frame_Shift_Del	novel	*F232Sfs7**	0.36
UCEC	chr20	41172263	Missense_Mutation	NA	C960Y	0.34
UCEC	chr20	41174263	Missense_Mutation	rs774703045	R1261H	0.67
UCEC	chr20	41173659	Silent	novel	N1134N	0.48
UCEC	chr20	41167922	Missense_Mutation	novel	T791N	0.29
UCEC	chr20	41166751	Silent	rs778521353	F731F	0.36
UCEC	chr20	41174735	3'UTR	novel		0.23
UCEC	chr20	41173452	Silent	novel	G1104G	0.13
UCEC	chr20	41169152	Missense_Mutation	rs753634028	V853M	0.17
UCEC	chr20	41166751	Silent	rs778521353	F731F	0.56
UCEC	chr20	41169139	Missense_Mutation	novel	E848D	0.51
UCEC	chr20	41165336	Missense_Mutation	rs191463364	G493D	0.37
UCEC	chr20	41170147	Missense_Mutation	rs146143589	V896I	0.25
UCEC	chr20	41175582	3'UTR	novel		0.26
UCEC	chr20	41166797	Missense_Mutation	NA	Y747H	0.15
UCEC	chr20	41164149	Missense_Mutation	novel	K389E	0.19
UCEC	chr20	41165015	Missense_Mutation	novel	G434W	0.26
UCEC	chr20	41159944	Missense_Mutation	novel	T149A	0.08
UCEC	chr20	41166307	Missense_Mutation	NA	H638R	0.38
UCEC	chr20	41159698	Missense_Mutation	novel	S104T	0.22
UCEC	chr20	41172841	Silent	NA	S1081S	0.51
UCEC	chr20	41170147	Missense_Mutation	rs146143589	V896I	0.48
UCEC	chr20	41173936	Silent	novel	V1190V	0.16
UCEC	chr20	41174307	Nonsense_Mutation	novel	R1276*	0.33
UCEC	chr20	41174483	Missense_Mutation	novel	R1283W	0.27
UCEC	chr20	41165755	Silent	rs775588772	T576T	0.26
UCEC	chr20	41174302	Missense_Mutation	rs372257814	R1274Q	0.36
UCEC	chr20	41173688	Missense_Mutation	novel	P1144L	0.35
UCEC	chr20	41172447	Missense_Mutation	rs755375534	R978W	0.39
UCEC	chr20	41163716	Missense_Mutation	novel	F298S	0.42
UCEC	chr20	41169477	Silent	rs150658422	P867P	0.46
UCEC	chr20	41166348	Nonsense_Mutation	NA	R652*	0.28
UCEC	chr20	41166525	Missense_Mutation	novel	R684C	0.34
UCEC	chr20	41169112	Silent	rs35738919	L839L	0.37
UCEC	chr20	41172642	Missense_Mutation	novel	P1043S	0.36
UCS	chr20	41172225	Silent	novel	K947K	0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	AMP	0.7073	1.2657e-35
LAML	DEL	0.0209	0.14746
LUAD	DEL	0.1202	0.18308
READ	AMP	0.8727	7.719e-21

Survival Analysis

Cancer	P-value	Q-value
THYM	0.00035	Kaplan-Meier Survival Analysis
SARC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.0051	Kaplan-Meier Survival Analysis
ACC	0.024	Kaplan-Meier Survival Analysis
HNSC	0.022	Kaplan-Meier Survival Analysis
PAAD	0.00081	Kaplan-Meier Survival Analysis
KICH	0.028	Kaplan-Meier Survival Analysis
UCEC	0.036	Kaplan-Meier Survival Analysis
LIHC	0.011	Kaplan-Meier Survival Analysis
THCA	0.037	Kaplan-Meier Survival Analysis
LUAD	0.004	Kaplan-Meier Survival Analysis
UVM	0.0033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000124181 (Gene tree)
Gene ID: 5335
Gene Symbol: PLCG1
Alias: PLC148|PLC-II|PLCgamma1|NCKAP3|PLC1
Full Name: phospholipase C gamma 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 59,842 bases
Position: chr20:41,136,960-41,196,801
Accession: 9065
RBP type: non-canonical RBP
Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14647465	Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68.	Oncogene	2003 Nov 27	Paronetto MP	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000609821	PLCG1-218	570	-	-	- (aa)	-	-
ENST00000477870	PLCG1-208	1051	-	-	- (aa)	-	-
ENST00000617873	PLCG1-220	583	-	-	- (aa)	-	-
ENST00000609257	PLCG1-217	956	-	ENSP00000476757	133 (aa)	-	V9GYH5
ENST00000599785	PLCG1-213	880	-	ENSP00000468958	50 (aa)	-	M0QX77
ENST00000630423	PLCG1-222	635	-	-	- (aa)	-	-
ENST00000244007	PLCG1-201	5285	XM_005260438	ENSP00000244007	1291 (aa)	XP_005260495	P19174
ENST00000483646	PLCG1-210	591	-	-	- (aa)	-	-
ENST00000483175	PLCG1-209	1084	-	-	- (aa)	-	-
ENST00000465571	PLCG1-205	543	-	-	- (aa)	-	-
ENST00000423733	PLCG1-203	498	-	-	- (aa)	-	-
ENST00000373271	PLCG1-202	7395	XM_011528867	ENSP00000362368	1290 (aa)	XP_011527169	P19174
ENST00000490253	PLCG1-211	527	-	-	- (aa)	-	-
ENST00000619272	PLCG1-221	330	-	-	- (aa)	-	-
ENST00000470528	PLCG1-206	510	-	-	- (aa)	-	-
ENST00000608885	PLCG1-216	865	-	ENSP00000476432	219 (aa)	-	V9GY63
ENST00000461641	PLCG1-204	936	-	-	- (aa)	-	-
ENST00000492148	PLCG1-212	597	-	-	- (aa)	-	-
ENST00000473632	PLCG1-207	412	-	-	- (aa)	-	-
ENST00000608689	PLCG1-215	969	-	-	- (aa)	-	-
ENST00000607954	PLCG1-214	1005	-	ENSP00000476454	108 (aa)	-	V9GY71
ENST00000612731	PLCG1-219	544	-	ENSP00000485760	132 (aa)	-	A0A0D9SEK2

Gene Model

Click here to download ENSG00000124181's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01521	EGFR tyrosine kinase inhibitor resistance	KEGG
hsa04012	ErbB signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04020	Calcium signaling pathway	KEGG
hsa04064	NF-kappa B signaling pathway	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG
hsa04072	Phospholipase D signaling pathway	KEGG
hsa04360	Axon guidance	KEGG
hsa04370	VEGF signaling pathway	KEGG
hsa04650	Natural killer cell mediated cytotoxicity	KEGG
hsa04658	Th1 and Th2 cell differentiation	KEGG
hsa04659	Th17 cell differentiation	KEGG
hsa04660	T cell receptor signaling pathway	KEGG
hsa04664	Fc epsilon RI signaling pathway	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04933	AGE-RAGE signaling pathway in diabetic complications	KEGG
hsa05110	Vibrio cholerae infection	KEGG
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	KEGG
hsa05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05214	Glioma	KEGG
hsa05223	Non-small cell lung cancer	KEGG
hsa05225	Hepatocellular carcinoma	KEGG
hsa05231	Choline metabolism in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124181	Blood Pressure	4E-8	27790247
ENSG00000124181	Cholesterol	4E-8	27790247
ENSG00000124181	Electrocardiography	4E-8	27790247
ENSG00000124181	Glucose	4E-8	27790247
ENSG00000124181	Hematocrit	4E-8	27790247
ENSG00000124181	Cholesterol, HDL	4E-8	27790247
ENSG00000124181	Triglycerides	4E-8	27790247
ENSG00000124181	Body Mass Index	4E-8	27790247
ENSG00000124181	Atrial Fibrillation	7E-7	27790247
ENSG00000124181	Blood Pressure	7E-7	27790247
ENSG00000124181	Cholesterol	7E-7	27790247
ENSG00000124181	Coronary Disease	7E-7	27790247
ENSG00000124181	Diabetes Mellitus	7E-7	27790247
ENSG00000124181	Electrocardiography	7E-7	27790247
ENSG00000124181	Glucose	7E-7	27790247
ENSG00000124181	Heart Failure	7E-7	27790247
ENSG00000124181	Hematocrit	7E-7	27790247
ENSG00000124181	Cholesterol, HDL	7E-7	27790247
ENSG00000124181	Mortality	7E-7	27790247
ENSG00000124181	Neoplasms	7E-7	27790247
ENSG00000124181	Triglycerides	7E-7	27790247
ENSG00000124181	Body Mass Index	7E-7	27790247
ENSG00000124181	Stroke	7E-7	27790247

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000124181	rs2228246	20	41163423	G	Major depressive disorder	27479909	[0.026-0.058] unit increase	0.042	EFO_0003761
ENSG00000124181	rs760762	20	41147406	?	Age-related disease endophenotypes	27790247			EFO_0004574\|EFO_0006336\|EFO_0004530\|EFO_0006335\|EFO_0004348\|EFO_0007928\|EFO_0004468\|EFO_0004340\|EFO_0004612
ENSG00000124181	rs6129767	20	41193692	T	Coronary artery disease	29212778	[0.025-0.052] unit decrease	0.0385	EFO_0000378
ENSG00000124181	rs753381	20	41168825	C	Hemoglobin concentration	27863252	[0.014-0.028] unit increase	0.02054587	EFO_0004509
ENSG00000124181	rs4297946	20	41182635	G	Total cholesterol levels	29507422	unit decrease	0.029	EFO_0004574
ENSG00000124181	rs4297946	20	41182635	G	Total cholesterol levels	29507422	unit decrease	0.027	EFO_0004574
ENSG00000124181	rs4297946	20	41182635	G	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.032	EFO_0004611
ENSG00000124181	rs4297946	20	41182635	G	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.03	EFO_0004611

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124181's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0001726	ruffle	17229814.	IDA	Component
GO:0004435	phosphatidylinositol phospholipase C activity	21873635.	IBA	Function
GO:0004435	phosphatidylinositol phospholipase C activity	2550068.	IDA	Function
GO:0004435	phosphatidylinositol phospholipase C activity	-	TAS	Function
GO:0004629	phospholipase C activity	-	TAS	Function
GO:0005168	neurotrophin TRKA receptor binding	15488758.	IPI	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	1396585.1656221.7537096.7537265.7693694.7993895.8321198.8627166.8628282.8657103.8892607.9020117.9045636.9489702.9593725.10811803.10873601.11796522.11896612.14568990.14570588.14722116.15641795.15929943.16273093.16525023.16921170.16938345.17229814.17474147.17936057.19264842.20808760.20932831.21706016.21725281.23063561.23397142.23460737.24440983.24642916.24728074.25241761.	IPI	Function
GO:0005737	cytoplasm	15702972.	IDA	Component
GO:0005829	cytosol	2550068.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	2550068.22454520.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005911	cell-cell junction	-	IEA	Component
GO:0007165	signal transduction	-	TAS	Process
GO:0007173	epidermal growth factor receptor signaling pathway	22454520.	IMP	Process
GO:0007202	activation of phospholipase C activity	-	TAS	Process
GO:0007411	axon guidance	-	TAS	Process
GO:0008180	COP9 signalosome	22561606.	IDA	Component
GO:0009395	phospholipid catabolic process	-	IEA	Process
GO:0010634	positive regulation of epithelial cell migration	21873635.	IBA	Process
GO:0010634	positive regulation of epithelial cell migration	17229814.	IMP	Process
GO:0010863	positive regulation of phospholipase C activity	-	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016477	cell migration	22454520.	IMP	Process
GO:0019722	calcium-mediated signaling	22454520.	IMP	Process
GO:0019901	protein kinase binding	22454520.	IPI	Function
GO:0030027	lamellipodium	17229814.	IDA	Component
GO:0030971	receptor tyrosine kinase binding	-	IEA	Function
GO:0032959	inositol trisphosphate biosynthetic process	21873635.	IBA	Process
GO:0035254	glutamate receptor binding	-	IEA	Function
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	Process
GO:0042995	cell projection	22454520.	IDA	Component
GO:0043536	positive regulation of blood vessel endothelial cell migration	20011604.	IDA	Process
GO:0043647	inositol phosphate metabolic process	-	TAS	Process
GO:0045766	positive regulation of angiogenesis	20011604.	IDA	Process
GO:0048015	phosphatidylinositol-mediated signaling	21873635.	IBA	Process
GO:0050804	modulation of chemical synaptic transmission	-	IEA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0050900	leukocyte migration	-	TAS	Process
GO:0051209	release of sequestered calcium ion into cytosol	21873635.	IBA	Process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	22454520.	IMP	Process
GO:0071364	cellular response to epidermal growth factor stimulus	17229814.	IDA	Process
GO:0071364	cellular response to epidermal growth factor stimulus	22454520.	IMP	Process
GO:0098685	Schaffer collateral - CA1 synapse	-	IEA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1905564	positive regulation of vascular endothelial cell proliferation	27464494.	IMP	Process
GO:2000353	positive regulation of endothelial cell apoptotic process	27464494.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.