EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29699373	Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor Types	Asian Pac J Cancer Prev	2018 Apr 27	Khan M	-
27000860	Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma.	Mol Cell Biochem	2016 Apr	Li Y	doi: 10.1007/s11010-016-2692-3
20951941	A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.	Cancer Cell	2010 Oct 19	Melo SA	doi: 10.1016/j.ccr.2010.09.007.
27553833	Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer.	Clin Cancer Res	2017 Mar 1	Shigeyasu K	doi: 10.1158/1078-0432.CCR-16-1023
26358254	MicroRNA-related single-nucleotide polymorphism of XPO5 is strongly correlated with the prognosis and chemotherapy response in advanced non-small-cell lung cancer patients.	Tumour Biol	2016 Feb	Geng JQ	doi: 10.1007/s13277-015-3980-3
26147304	3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.	PLoS One	2015 Jul 6	Cho SH	doi: 10.1371/journal.pone.0131125
28383405	Association of microRNA-related gene XPO5 rs11077 polymorphism with susceptibility to thyroid cancer.	Medicine (Baltimore)	2017 Apr	Wen J	doi: 10.1097/MD.0000000000006351.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	43524861	Silent	novel	V1094V	0.34
BLCA	chr6	43575876	5'UTR	novel		0.37
BLCA	chr6	43570599	Missense_Mutation	NA	R175I	0.18	Xpo1
BLCA	chr6	43573569	Silent	novel	I46I	0.58
BLCA	chr6	43548334	Nonsense_Mutation	novel	E663*	0.33
BLCA	chr6	43527721	Missense_Mutation	rs375072367	E945K	0.44
BLCA	chr6	43528878	Missense_Mutation	novel	E909K	0.28
BLCA	chr6	43548274	Nonsense_Mutation	NA	Q683*	0.2
BLCA	chr6	43573541	Missense_Mutation	novel	E56Q	0.08
BLCA	chr6	43527727	Missense_Mutation	NA	E943K	0.28
BLCA	chr6	43551438	Missense_Mutation	novel	D530H	0.48
BLCA	chr6	43530746	Silent	novel	L873L	0.49
BLCA	chr6	43575872	5'UTR	novel		0.24
BLCA	chr6	43553427	Missense_Mutation	NA	M506I	0.2
BLCA	chr6	43560995	Missense_Mutation	NA	D342H	0.16
BLCA	chr6	43523646	3'UTR	novel		0.17
BLCA	chr6	43524489	Silent	NA	L1153L	0.2
BLCA	chr6	43523637	3'UTR	novel		0.19
BLCA	chr6	43575855	Missense_Mutation	novel	D4H	0.12
BRCA	chr6	43549566	Missense_Mutation	rs762469874	R595W	0.05
BRCA	chr6	43565657	Splice_Region	novel		0.26
BRCA	chr6	43560293	Missense_Mutation	novel	S369Y	0.21
BRCA	chr6	43548408	Missense_Mutation	NA	L638P	0.5
BRCA	chr6	43546609	Missense_Mutation	novel	Q768H	0.12
BRCA	chr6	43526725	Silent	NA	K981K	0.28
BRCA	chr6	43548415	Missense_Mutation	novel	N636H	0.06
BRCA	chr6	43523891	Missense_Mutation	NA	L1198M	0.29
BRCA	chr6	43530741	Missense_Mutation	novel	S875L	0.24
BRCA	chr6	43567178	Silent	NA	V275V	0.46
BRCA	chr6	43573507	Missense_Mutation	NA	G67A	0.17
BRCA	chr6	43567352	Splice_Region	rs765845766	A217A	0.43
BRCA	chr6	43570949	Missense_Mutation	NA	L116V	0.16	Xpo1
CESC	chr6	43522714	3'UTR	novel		0.28
CESC	chr6	43524937	Frame_Shift_Ins	novel	*V1069Afs52**	0.13
CESC	chr6	43567173	Missense_Mutation	NA	R277K	0.17
CESC	chr6	43522801	3'UTR	novel		0.32
CESC	chr6	43547678	Missense_Mutation	rs202182348	A697V	0.4
CESC	chr6	43524515	Missense_Mutation	NA	R1145C	0.51
CHOL	chr6	43570539	Missense_Mutation	novel	N195T	0.1	Xpo1
COAD	chr6	43573573	Missense_Mutation	NA	P45H	0.16
COAD	chr6	43523806	3'UTR	rs752163480		0.22
COAD	chr6	43548331	Missense_Mutation	rs759225284	R664C	0.24
COAD	chr6	43560955	Missense_Mutation	novel	S355Y	0.08
COAD	chr6	43547612	Missense_Mutation	novel	A719V	0.43
COAD	chr6	43560271	Frame_Shift_Ins	NA	*A377Sfs6**	0.38
COAD	chr6	43546751	Missense_Mutation	NA	M721T	0.37
COAD	chr6	43522755	3'UTR	novel		0.3
COAD	chr6	43560178	Missense_Mutation	novel	K407N	0.38
COAD	chr6	43562274	Silent	rs754664679	A328A	0.19
COAD	chr6	43534004	Silent	novel	T782T	0.26
COAD	chr6	43572573	Missense_Mutation	rs746237786	R78Q	0.15
COAD	chr6	43558587	Missense_Mutation	NA	G409D	0.4
COAD	chr6	43531525	Missense_Mutation	rs377196219	V832I	0.28
COAD	chr6	43570914	Silent	novel	E127E	0.14
COAD	chr6	43553445	Silent	rs772506045	F500F	0.14
COAD	chr6	43558508	Missense_Mutation	NA	F435L	0.3
COAD	chr6	43560204	Missense_Mutation	NA	R399C	0.14
COAD	chr6	43523902	Missense_Mutation	NA	D1194G	0.33
COAD	chr6	43547686	Silent	NA	A694A	0.06
COAD	chr6	43548322	Missense_Mutation	rs760578587	V667M	0.27
ESCA	chr6	43570638	Missense_Mutation	novel	E162A	0.24	Xpo1
ESCA	chr6	43570514	Missense_Mutation	novel	K203N	0.22	Xpo1
ESCA	chr6	43560265	Silent	novel	L378L	0.21
ESCA	chr6	43560981	Silent	novel	P346P	0.35
GBM	chr6	43523609	3'UTR	novel		0.25
GBM	chr6	43524934	Missense_Mutation	rs774492981	T1070M	0.41
GBM	chr6	43549524	Missense_Mutation	novel	I609F	0.12
HNSC	chr6	43524511	Missense_Mutation	rs765690738	R1146Q	0.22
HNSC	chr6	43529284	Intron	novel		0.28
HNSC	chr6	43570969	Missense_Mutation	novel	E109G	0.2
HNSC	chr6	43523721	3'UTR	novel		0.45
HNSC	chr6	43575916	5'UTR	novel		0.39
HNSC	chr6	43524628	Missense_Mutation	novel	R1107M	0.29
KIRC	chr6	43560296	Missense_Mutation	rs774916295	R368H	0.23
KIRC	chr6	43524588	Silent	NA	E1120E	0.22
KIRC	chr6	43547703	Silent	NA	L689L	0.35
KIRC	chr6	43525920	Splice_Region	NA	D995D	0.24
KIRC	chr6	43529317	Intron	novel		0.05
KIRP	chr6	43530699	Missense_Mutation	novel	R889T	0.36
KIRP	chr6	43531510	Missense_Mutation	novel	Q837K	0.38
LGG	chr6	43523617	3'UTR	novel		0.37
LGG	chr6	43523842	3'UTR	rs758384615		0.42
LIHC	chr6	43558529	Silent	rs764721782	S428S	0.11
LIHC	chr6	43549924	Missense_Mutation	NA	S580F	0.61
LIHC	chr6	43531540	Missense_Mutation	novel	P827S	0.04
LIHC	chr6	43524589	Missense_Mutation	novel	E1120V	0.4
LIHC	chr6	43546658	Missense_Mutation	novel	G752A	0.23
LIHC	chr6	43558561	Missense_Mutation	novel	S418C	0.74
LIHC	chr6	43525194	Silent	novel	L1029L	0.17
LUAD	chr6	43531559	Silent	novel	L820L	0.09
LUAD	chr6	43570930	Missense_Mutation	NA	E122V	0.29	Xpo1
LUAD	chr6	43531532	Missense_Mutation	novel	F829L	0.05
LUAD	chr6	43530765	Frame_Shift_Del	novel	*V865Afs14**	0.04
LUAD	chr6	43530793	Missense_Mutation	NA	M858L	0.18
LUAD	chr6	43548301	Missense_Mutation	NA	A674S	0.06
LUAD	chr6	43528867	Silent	novel	V912V	0.14
LUAD	chr6	43570655	Nonsense_Mutation	novel	*I156_L157insKDF**	0.07	Xpo1
LUAD	chr6	43570649	Missense_Mutation	novel	L158F	0.22	Xpo1
LUAD	chr6	43530751	Frame_Shift_Ins	novel	*L872Ifs16**	0.08
LUAD	chr6	43570937	Missense_Mutation	NA	V120I	0.33	Xpo1
LUSC	chr6	43575953	5'UTR	novel		0.39
LUSC	chr6	43531540	Missense_Mutation	novel	P827A	0.1
LUSC	chr6	43567253	Silent	NA	L250L	0.21
LUSC	chr6	43530694	Missense_Mutation	NA	M891L	0.12
LUSC	chr6	43570528	Missense_Mutation	NA	E199K	0.4	Xpo1
LUSC	chr6	43523557	3'UTR	novel		0.17
LUSC	chr6	43570993	Missense_Mutation	novel	G101E	0.18
MESO	chr6	43533963	Missense_Mutation	novel	A796V	0.24
OV	chr6	43525192	Nonsense_Mutation	novel	*I1030Tfs9**	0.51
OV	chr6	43546739	Missense_Mutation	novel	V725A	0.22
OV	chr6	43523838	3'UTR	novel		0.38
OV	chr6	43524593	Missense_Mutation	novel	P1119S	0.1
OV	chr6	43575762	Nonsense_Mutation	novel	K35*	0.24
OV	chr6	43523485	3'UTR	novel		0.25
OV	chr6	43527631	Splice_Region	novel		0.44
PAAD	chr6	43576001	5'UTR	novel		0.11
PRAD	chr6	43551377	Missense_Mutation	NA	S550F	0.31
PRAD	chr6	43572564	Missense_Mutation	novel	G81V	0.46
READ	chr6	43524634	Missense_Mutation	novel	R1105H	0.04
READ	chr6	43548326	Silent	NA	Q665Q	0.23
READ	chr6	43553390	Nonsense_Mutation	NA	R519*	0.54
READ	chr6	43523857	3'UTR	novel		0.09
SARC	chr6	43523707	3'UTR	novel		0.3
SARC	chr6	43523708	3'UTR	novel		0.3
SKCM	chr6	43548460	Missense_Mutation	novel	P621S	0.24
SKCM	chr6	43528833	Missense_Mutation	novel	H924Y	0.24
SKCM	chr6	43528834	Silent	novel	L923L	0.22
SKCM	chr6	43560197	Missense_Mutation	novel	S401F	0.3
SKCM	chr6	43533906	Splice_Site	novel	X815_splice	0.13
SKCM	chr6	43555923	Missense_Mutation	NA	R452C	0.12
SKCM	chr6	43570654	Missense_Mutation	NA	L157F	0.14	Xpo1
SKCM	chr6	43565714	Missense_Mutation	NA	P286L	0.3
SKCM	chr6	43546732	Silent	rs369471517	S727S	0.63
SKCM	chr6	43558548	Missense_Mutation	NA	S422F	0.36
SKCM	chr6	43575784	Missense_Mutation	NA	Q27H	0.45
SKCM	chr6	43568710	Splice_Site	novel	X216_splice	0.23
SKCM	chr6	43568711	Splice_Region	novel	K216K	0.24
SKCM	chr6	43548276	Missense_Mutation	NA	S682F	0.34
SKCM	chr6	43549564	Silent	NA	R595R	0.5
SKCM	chr6	43560204	Missense_Mutation	NA	R399C	0.15
SKCM	chr6	43555960	Silent	novel	S439S	0.16
SKCM	chr6	43546568	Splice_Region	novel		0.48
SKCM	chr6	43572533	Silent	novel	K91K	0.39
SKCM	chr6	43523744	3'UTR	novel		0.07
STAD	chr6	43526710	Silent	NA	S986S	0.08
STAD	chr6	43524477	Missense_Mutation	novel	C1157W	0.08
STAD	chr6	43548334	Missense_Mutation	rs764867205	E663K	0.23
STAD	chr6	43573601	Missense_Mutation	NA	F36I	0.14
STAD	chr6	43523895	Frame_Shift_Ins	novel	*G1197Wfs7**	0.38
STAD	chr6	43575802	Missense_Mutation	NA	M21I	0.24
STAD	chr6	43547677	Silent	rs774272076	A697A	0.18
THCA	chr6	43530751	Frame_Shift_Ins	novel	*L872Ifs16**	0.06
UCEC	chr6	43528855	Silent	rs764175153	L916L	0.29
UCEC	chr6	43523978	Nonsense_Mutation	NA	E1169*	0.4
UCEC	chr6	43533921	Missense_Mutation	NA	K810T	0.3
UCEC	chr6	43553389	Missense_Mutation	rs746618680	R519Q	0.38
UCEC	chr6	43526697	Missense_Mutation	novel	A991T	0.09
UCEC	chr6	43528181	Missense_Mutation	NA	I934V	0.52
UCEC	chr6	43533982	Nonsense_Mutation	NA	E790*	0.4
UCEC	chr6	43546706	Missense_Mutation	novel	C736F	0.05
UCEC	chr6	43551373	Silent	rs770243870	C551C	0.44
UCEC	chr6	43525187	Missense_Mutation	novel	A1032S	0.44
UCEC	chr6	43553445	Silent	rs772506045	F500F	0.45
UCEC	chr6	43558566	Missense_Mutation	novel	S416N	0.42
UCEC	chr6	43523823	3'UTR	novel		0.14
UCEC	chr6	43529271	Intron	rs368932102		0.23
UCEC	chr6	43568735	In_Frame_Ins	novel	K208_T209insQKKQT	0.04	Xpo1
UCEC	chr6	43553374	Missense_Mutation	NA	E524G	0.26
UCEC	chr6	43568731	Missense_Mutation	novel	D210Y	0.05	Xpo1
UCEC	chr6	43570556	Silent	novel	I189I	0.17
UCEC	chr6	43558508	Missense_Mutation	NA	F435L	0.43
UCEC	chr6	43560219	Missense_Mutation	novel	I394L	0.51
UCEC	chr6	43548330	Missense_Mutation	rs753547042	R664H	0.29
UCEC	chr6	43558502	Splice_Region	novel	N437N	0.5
UCEC	chr6	43560287	Missense_Mutation	novel	T371N	0.37
UCEC	chr6	43531525	Missense_Mutation	rs377196219	V832I	0.34
UCEC	chr6	43546712	Missense_Mutation	rs748684361	R734Q	0.4
UCEC	chr6	43548419	Silent	novel	L634L	0.5
UCEC	chr6	43549565	Missense_Mutation	rs368843561	R595Q	0.53
UCEC	chr6	43570919	Nonsense_Mutation	novel	R126*	0.11	Xpo1
UCEC	chr6	43523806	3'UTR	rs752163480		0.58
UCEC	chr6	43530822	Missense_Mutation	novel	F848Y	0.42
UCEC	chr6	43549519	Missense_Mutation	novel	K610N	0.54
UCEC	chr6	43555857	Missense_Mutation	novel	L474I	0.41
UCEC	chr6	43523738	3'UTR	novel		0.25
UCEC	chr6	43524493	Missense_Mutation	rs766940966	R1152H	0.37
UCEC	chr6	43565687	Missense_Mutation	NA	A295V	0.42
UCEC	chr6	43522695	3'UTR	rs536522462		0.43
UCEC	chr6	43553389	Missense_Mutation	rs746618680	R519Q	0.33
UCEC	chr6	43570647	Missense_Mutation	novel	R159Q	0.35	Xpo1
UCEC	chr6	43573497	Silent	novel	I70I	0.41
UCEC	chr6	43524944	Missense_Mutation	novel	D1067Y	0.19
UCEC	chr6	43530700	Silent	novel	R889R	0.39
UCEC	chr6	43570971	Missense_Mutation	novel	E108D	0.37
UCEC	chr6	43523806	3'UTR	rs752163480		0.26
UCEC	chr6	43525163	Missense_Mutation	novel	D1040Y	0.53
UCEC	chr6	43531515	Missense_Mutation	novel	R835I	0.31
UCEC	chr6	43533904	Splice_Region	novel		0.22
UCEC	chr6	43549538	Missense_Mutation	novel	A604V	0.05
UCEC	chr6	43522715	3'UTR	rs765625820		0.81
UCEC	chr6	43531495	Missense_Mutation	novel	T842A	0.1
UCEC	chr6	43546697	Missense_Mutation	NA	T739I	0.05
UCEC	chr6	43555959	Nonsense_Mutation	NA	R440*	0.34
UCEC	chr6	43525141	Missense_Mutation	novel	T1047R	0.48
UCEC	chr6	43560996	Silent	NA	S341S	0.26
UCEC	chr6	43522702	3'UTR	novel		0.45
UCEC	chr6	43522683	3'UTR	novel		0.28
UCEC	chr6	43547615	Missense_Mutation	NA	R718H	0.23
UCEC	chr6	43524934	Missense_Mutation	rs774492981	T1070M	0.24
UCEC	chr6	43529348	Intron	novel		0.3
UCEC	chr6	43533929	Silent	rs763541168	D807D	0.17
UCEC	chr6	43546579	Silent	NA	A778A	0.4
UCEC	chr6	43560224	Missense_Mutation	novel	A392V	0.33
UCEC	chr6	43570611	Missense_Mutation	novel	P171L	0.23	Xpo1
UCEC	chr6	43549580	Splice_Site	novel	X591_splice	0.43
UCEC	chr6	43527655	Nonsense_Mutation	novel	R967*	0.32
UCEC	chr6	43522662	3'UTR	rs764517398		0.38
UCEC	chr6	43562261	Missense_Mutation	novel	L333M	0.36
UCS	chr6	43533991	Missense_Mutation	novel	Y787H	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	AMP	0.1752	0.005341
READ	AMP	0.2909	0.02906

Survival Analysis

Cancer	P-value	Q-value
THYM	0.035	Kaplan-Meier Survival Analysis
KIRC	0.018	Kaplan-Meier Survival Analysis
SARC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.0013	Kaplan-Meier Survival Analysis
PAAD	0.043	Kaplan-Meier Survival Analysis
BLCA	0.019	Kaplan-Meier Survival Analysis
CESC	0.017	Kaplan-Meier Survival Analysis
KICH	0.0072	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000124571 (Gene tree)
Gene ID: 57510
Gene Symbol: XPO5
Alias: KIAA1291
Full Name: exportin 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 53,746 bases
Position: chr6:43,522,330-43,576,075
Accession: 17675
RBP type: canonical RBP
Summary: This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000265351	Xpo1	PF08389.12	2.1e-32	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19124606	RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.	Mol Cell Biol	2009 Mar	Fritz J	doi: 10.1128/MCB.01519-08
12509441	Exportin-5 mediates nuclear export of minihelix-containing RNAs.	J Biol Chem	2003 Feb 21	Gwizdek C	-
12426392	Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.	EMBO J	2002 Nov 15	Bohnsack MT	-
11777942	Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.	J Cell Biol	2002 Jan 7	Brownawell AM	-
15254228	Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.	Mol Cell Biol	2004 Aug	Chen T	-
15166236	The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export.	J Biol Chem	2004 Jul 23	Macchi P	-
14570900	Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3.	J Biol Chem	2004 Jan 9	Gwizdek C	-
19301657	Protein components of the microRNA pathway and human diseases.	Methods Mol Biol	2009	Perron MP	doi: 10.1007/978-1-60327-547-7_18.
18366743	The evolution of core proteins involved in microRNA biogenesis.	BMC Evol Biol	2008 Mar 25	Murphy D	doi: 10.1186/1471-2148-8-92.
16963774	Exportin-5 orthologues are functionally divergent among species.	Nucleic Acids Res	2006	Shibata S	-
29728564	Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.	Sci Rep	2018 May 4	Ederle H	doi: 10.1038/s41598-018-25007-5.
22593162	A baculovirus-encoded MicroRNA (miRNA) suppresses its host miRNA biogenesis by regulating the exportin-5 cofactor Ran.	J Virol	2012 Aug	Singh CP	doi: 10.1128/JVI.00064-12
15542639	Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis.	J Virol	2004 Dec	Lu S	-
15356295	Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.	Nucleic Acids Res	2004 Sep 8	Zeng Y	-
21297638	Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.	Nat Struct Mol Biol	2011 Mar	Bennasser Y	doi: 10.1038/nsmb.1987

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000398799	XPO5-202	568	-	ENSP00000381779	76 (aa)	-	E2QRM3
ENST00000265351	XPO5-201	5364	-	ENSP00000265351	1204 (aa)	-	Q9HAV4
ENST00000450462	XPO5-205	633	-	-	- (aa)	-	-
ENST00000455285	XPO5-206	758	-	ENSP00000387384	253 (aa)	-	H0Y3W3
ENST00000424378	XPO5-204	624	-	-	- (aa)	-	-
ENST00000612911	XPO5-212	911	-	-	- (aa)	-	-
ENST00000513451	XPO5-211	232	-	-	- (aa)	-	-
ENST00000488195	XPO5-209	868	-	-	- (aa)	-	-
ENST00000455854	XPO5-207	3629	-	-	- (aa)	-	-
ENST00000496341	XPO5-210	800	-	ENSP00000424196	107 (aa)	-	H0Y9I3
ENST00000486936	XPO5-208	601	-	ENSP00000426185	60 (aa)	-	H0YA57
ENST00000398835	XPO5-203	868	-	ENSP00000381816	24 (aa)	-	H0Y3Q8

Gene Model

Click here to download ENSG00000124571's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124571's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000124571	XPO5	96	72.603	ENSAPOG00000018844	si:ch211-233m11.2	99	68.037	Acanthochromis_polyacanthus
ENSG00000124571	XPO5	100	97.368	ENSAMEG00000012197	XPO5	100	94.274	Ailuropoda_melanoleuca
ENSG00000124571	XPO5	96	75.342	ENSACIG00000020796	si:ch211-233m11.2	99	60.450	Amphilophus_citrinellus
ENSG00000124571	XPO5	96	72.603	ENSAOCG00000004757	si:ch211-233m11.2	94	61.596	Amphiprion_ocellaris
ENSG00000124571	XPO5	96	72.603	ENSAPEG00000012728	si:ch211-233m11.2	94	62.340	Amphiprion_percula
ENSG00000124571	XPO5	96	69.863	ENSATEG00000002222	si:ch211-233m11.2	99	60.887	Anabas_testudineus
ENSG00000124571	XPO5	92	91.837	ENSAPLG00000001469	XPO5	100	82.742	Anas_platyrhynchos
ENSG00000124571	XPO5	100	88.158	ENSACAG00000009808	XPO5	98	81.319	Anolis_carolinensis
ENSG00000124571	XPO5	100	98.505	ENSANAG00000029648	XPO5	100	98.505	Aotus_nancymaae
ENSG00000124571	XPO5	96	71.233	ENSACLG00000011682	si:ch211-233m11.2	99	57.541	Astatotilapia_calliptera
ENSG00000124571	XPO5	96	69.863	ENSAMXG00000005187	XPO5	99	63.789	Astyanax_mexicanus
ENSG00000124571	XPO5	100	94.103	ENSBTAG00000018970	XPO5	100	94.103	Bos_taurus
ENSG00000124571	XPO5	100	98.256	ENSCJAG00000005612	XPO5	100	98.256	Callithrix_jacchus
ENSG00000124571	XPO5	100	97.368	ENSCAFG00000001892	XPO5	100	95.104	Canis_familiaris
ENSG00000124571	XPO5	100	92.940	ENSCHIG00000011271	XPO5	100	92.940	Capra_hircus
ENSG00000124571	XPO5	99	91.270	ENSCPOG00000009917	XPO5	100	92.051	Cavia_porcellus
ENSG00000124571	XPO5	100	98.339	ENSCCAG00000017800	XPO5	100	98.339	Cebus_capucinus
ENSG00000124571	XPO5	100	99.419	ENSCATG00000036321	XPO5	100	99.419	Cercocebus_atys
ENSG00000124571	XPO5	100	96.053	ENSCLAG00000009723	XPO5	100	92.199	Chinchilla_lanigera
ENSG00000124571	XPO5	100	99.419	ENSCSAG00000012047	XPO5	100	99.419	Chlorocebus_sabaeus
ENSG00000124571	XPO5	93	96.970	ENSCHOG00000006606	XPO5	94	84.397	Choloepus_hoffmanni
ENSG00000124571	XPO5	100	88.158	ENSCPBG00000025210	XPO5	100	84.424	Chrysemys_picta_bellii
ENSG00000124571	XPO5	96	32.432	ENSCSAVG00000008842	-	85	33.858	Ciona_savignyi
ENSG00000124571	XPO5	100	99.336	ENSCANG00000043106	XPO5	100	99.336	Colobus_angolensis_palliatus
ENSG00000124571	XPO5	100	92.105	ENSCGRG00001010034	Xpo5	100	86.794	Cricetulus_griseus_chok1gshd
ENSG00000124571	XPO5	100	92.105	ENSCGRG00000013221	Xpo5	100	86.722	Cricetulus_griseus_crigri
ENSG00000124571	XPO5	95	68.919	ENSCSEG00000004593	XPO5	97	59.677	Cynoglossus_semilaevis
ENSG00000124571	XPO5	96	68.493	ENSCVAG00000014491	si:ch211-233m11.2	99	59.155	Cyprinodon_variegatus
ENSG00000124571	XPO5	96	69.863	ENSDARG00000098868	XPO5	99	68.000	Danio_rerio
ENSG00000124571	XPO5	100	97.368	ENSDNOG00000009443	XPO5	91	91.128	Dasypus_novemcinctus
ENSG00000124571	XPO5	100	93.421	ENSDORG00000000432	Xpo5	100	92.715	Dipodomys_ordii
ENSG00000124571	XPO5	99	35.266	FBgn0031051	Ranbp21	99	35.332	Drosophila_melanogaster
ENSG00000124571	XPO5	95	94.286	ENSETEG00000010810	XPO5	95	94.286	Echinops_telfairi
ENSG00000124571	XPO5	73	47.805	ENSEBUG00000011631	si:ch211-233m11.2	95	47.805	Eptatretus_burgeri
ENSG00000124571	XPO5	100	97.368	ENSEASG00005003351	XPO5	100	96.595	Equus_asinus_asinus
ENSG00000124571	XPO5	92	86.364	ENSEEUG00000005499	XPO5	100	74.357	Erinaceus_europaeus
ENSG00000124571	XPO5	93	76.056	ENSELUG00000021008	si:ch211-233m11.2	99	64.590	Esox_lucius
ENSG00000124571	XPO5	100	97.368	ENSFCAG00000009737	XPO5	100	93.355	Felis_catus
ENSG00000124571	XPO5	92	90.816	ENSFALG00000012130	XPO5	100	81.810	Ficedula_albicollis
ENSG00000124571	XPO5	100	96.053	ENSFDAG00000007516	XPO5	100	92.869	Fukomys_damarensis
ENSG00000124571	XPO5	96	67.123	ENSFHEG00000022609	si:ch211-233m11.2	99	59.069	Fundulus_heteroclitus
ENSG00000124571	XPO5	96	75.342	ENSGMOG00000012528	si:ch211-233m11.2	99	60.298	Gadus_morhua
ENSG00000124571	XPO5	100	88.158	ENSGALG00000010341	XPO5	100	82.921	Gallus_gallus
ENSG00000124571	XPO5	96	65.753	ENSGAFG00000009505	si:ch211-233m11.2	99	58.589	Gambusia_affinis
ENSG00000124571	XPO5	96	68.493	ENSGACG00000008050	si:ch211-233m11.2	99	61.653	Gasterosteus_aculeatus
ENSG00000124571	XPO5	100	88.158	ENSGAGG00000010628	XPO5	100	83.607	Gopherus_agassizii
ENSG00000124571	XPO5	100	99.086	ENSGGOG00000007940	XPO5	100	99.086	Gorilla_gorilla
ENSG00000124571	XPO5	96	71.233	ENSHBUG00000022345	si:ch211-233m11.2	99	59.903	Haplochromis_burtoni
ENSG00000124571	XPO5	100	96.053	ENSHGLG00000019191	XPO5	100	92.863	Heterocephalus_glaber_female
ENSG00000124571	XPO5	100	91.618	ENSHGLG00100014203	XPO5	100	91.618	Heterocephalus_glaber_male
ENSG00000124571	XPO5	91	59.794	ENSHCOG00000003642	si:ch211-233m11.2	99	55.556	Hippocampus_comes
ENSG00000124571	XPO5	93	76.056	ENSIPUG00000007740	XPO5	99	64.760	Ictalurus_punctatus
ENSG00000124571	XPO5	100	96.053	ENSSTOG00000020172	XPO5	100	95.266	Ictidomys_tridecemlineatus
ENSG00000124571	XPO5	100	92.105	ENSJJAG00000009521	Xpo5	100	90.615	Jaculus_jaculus
ENSG00000124571	XPO5	96	69.863	ENSKMAG00000004007	XPO5	99	58.296	Kryptolebias_marmoratus
ENSG00000124571	XPO5	96	72.603	ENSLBEG00000008107	si:ch211-233m11.2	99	60.379	Labrus_bergylta
ENSG00000124571	XPO5	100	77.632	ENSLACG00000011825	XPO5	99	65.571	Latimeria_chalumnae
ENSG00000124571	XPO5	100	77.632	ENSLOCG00000015733	si:ch211-233m11.2	99	66.968	Lepisosteus_oculatus
ENSG00000124571	XPO5	99	93.651	ENSLAFG00000000567	XPO5	100	94.449	Loxodonta_africana
ENSG00000124571	XPO5	100	99.502	ENSMFAG00000038120	XPO5	100	99.502	Macaca_fascicularis
ENSG00000124571	XPO5	100	99.502	ENSMMUG00000015193	XPO5	100	99.502	Macaca_mulatta
ENSG00000124571	XPO5	100	99.502	ENSMNEG00000035404	XPO5	100	99.502	Macaca_nemestrina
ENSG00000124571	XPO5	100	99.502	ENSMLEG00000035689	XPO5	100	99.502	Mandrillus_leucophaeus
ENSG00000124571	XPO5	100	69.737	ENSMAMG00000021525	si:ch211-233m11.2	99	60.442	Mastacembelus_armatus
ENSG00000124571	XPO5	96	71.233	ENSMZEG00005027653	si:ch211-233m11.2	99	60.231	Maylandia_zebra
ENSG00000124571	XPO5	92	91.837	ENSMGAG00000010938	XPO5	100	82.601	Meleagris_gallopavo
ENSG00000124571	XPO5	100	92.105	ENSMAUG00000011670	Xpo5	100	86.213	Mesocricetus_auratus
ENSG00000124571	XPO5	100	95.436	ENSMICG00000005032	XPO5	100	95.436	Microcebus_murinus
ENSG00000124571	XPO5	100	92.105	ENSMOCG00000016105	Xpo5	100	86.545	Microtus_ochrogaster
ENSG00000124571	XPO5	96	69.863	ENSMMOG00000010447	si:ch211-233m11.2	99	57.882	Mola_mola
ENSG00000124571	XPO5	100	88.158	ENSMODG00000018963	XPO5	100	87.150	Monodelphis_domestica
ENSG00000124571	XPO5	96	69.863	ENSMALG00000004677	si:ch211-233m11.2	99	58.615	Monopterus_albus
ENSG00000124571	XPO5	100	92.105	MGP_CAROLIEiJ_G0021661	Xpo5	100	87.957	Mus_caroli
ENSG00000124571	XPO5	100	92.105	ENSMUSG00000067150	Xpo5	100	87.708	Mus_musculus
ENSG00000124571	XPO5	100	92.105	MGP_PahariEiJ_G0020653	Xpo5	100	87.874	Mus_pahari
ENSG00000124571	XPO5	100	92.105	MGP_SPRETEiJ_G0022573	Xpo5	100	87.625	Mus_spretus
ENSG00000124571	XPO5	100	96.053	ENSMPUG00000012904	-	100	92.879	Mustela_putorius_furo
ENSG00000124571	XPO5	100	96.053	ENSMLUG00000017752	XPO5	100	94.279	Myotis_lucifugus
ENSG00000124571	XPO5	100	93.421	ENSNGAG00000015950	Xpo5	100	86.545	Nannospalax_galili
ENSG00000124571	XPO5	96	71.233	ENSNBRG00000020176	si:ch211-233m11.2	99	59.736	Neolamprologus_brichardi
ENSG00000124571	XPO5	100	98.684	ENSNLEG00000003966	XPO5	100	95.847	Nomascus_leucogenys
ENSG00000124571	XPO5	99	94.667	ENSOPRG00000000146	XPO5	92	93.312	Ochotona_princeps
ENSG00000124571	XPO5	100	94.737	ENSODEG00000017078	XPO5	100	91.104	Octodon_degus
ENSG00000124571	XPO5	96	71.233	ENSONIG00000018463	si:ch211-233m11.2	99	61.006	Oreochromis_niloticus
ENSG00000124571	XPO5	93	89.899	ENSOANG00000012106	-	100	85.918	Ornithorhynchus_anatinus
ENSG00000124571	XPO5	100	96.053	ENSOCUG00000005510	XPO5	100	95.270	Oryctolagus_cuniculus
ENSG00000124571	XPO5	96	67.123	ENSORLG00000007230	si:ch211-233m11.2	99	57.718	Oryzias_latipes
ENSG00000124571	XPO5	96	67.123	ENSORLG00020004548	si:ch211-233m11.2	99	57.904	Oryzias_latipes_hni
ENSG00000124571	XPO5	96	67.123	ENSORLG00015000295	si:ch211-233m11.2	99	57.904	Oryzias_latipes_hsok
ENSG00000124571	XPO5	96	67.123	ENSOMEG00000004338	XPO5	98	57.735	Oryzias_melastigma
ENSG00000124571	XPO5	100	94.737	ENSOGAG00000016321	XPO5	100	93.278	Otolemur_garnettii
ENSG00000124571	XPO5	100	94.435	ENSOARG00000007607	XPO5	100	94.435	Ovis_aries
ENSG00000124571	XPO5	100	98.684	ENSPPAG00000039971	XPO5	100	97.342	Pan_paniscus
ENSG00000124571	XPO5	100	97.368	ENSPPRG00000009028	XPO5	100	93.439	Panthera_pardus
ENSG00000124571	XPO5	98	95.443	ENSPTIG00000011671	XPO5	100	95.443	Panthera_tigris_altaica
ENSG00000124571	XPO5	100	99.751	ENSPTRG00000018204	XPO5	100	99.751	Pan_troglodytes
ENSG00000124571	XPO5	100	98.684	ENSPANG00000004080	XPO5	100	98.592	Papio_anubis
ENSG00000124571	XPO5	93	76.056	ENSPKIG00000021336	si:ch211-233m11.2	99	66.472	Paramormyrops_kingsleyae
ENSG00000124571	XPO5	96	64.384	ENSPMGG00000022509	XPO5	99	57.650	Periophthalmus_magnuspinnatus
ENSG00000124571	XPO5	97	86.655	ENSPEMG00000020387	Xpo5	100	86.655	Peromyscus_maniculatus_bairdii
ENSG00000124571	XPO5	95	54.167	ENSPMAG00000005443	si:ch211-233m11.2	99	46.596	Petromyzon_marinus
ENSG00000124571	XPO5	100	88.158	ENSPCIG00000028142	XPO5	100	85.762	Phascolarctos_cinereus
ENSG00000124571	XPO5	96	71.233	ENSPFOG00000004497	si:ch211-233m11.2	99	59.247	Poecilia_formosa
ENSG00000124571	XPO5	96	71.233	ENSPLAG00000009067	si:ch211-233m11.2	99	59.165	Poecilia_latipinna
ENSG00000124571	XPO5	96	71.233	ENSPMEG00000016885	si:ch211-233m11.2	99	59.165	Poecilia_mexicana
ENSG00000124571	XPO5	96	71.233	ENSPREG00000017998	si:ch211-233m11.2	99	58.492	Poecilia_reticulata
ENSG00000124571	XPO5	100	99.003	ENSPPYG00000016646	XPO5	100	99.003	Pongo_abelii
ENSG00000124571	XPO5	100	96.053	ENSPCAG00000005038	XPO5	91	92.754	Procavia_capensis
ENSG00000124571	XPO5	100	97.368	ENSPCOG00000028854	XPO5	100	96.598	Propithecus_coquereli
ENSG00000124571	XPO5	100	96.053	ENSPVAG00000005691	XPO5	100	95.515	Pteropus_vampyrus
ENSG00000124571	XPO5	96	71.233	ENSPNYG00000012685	si:ch211-233m11.2	99	58.051	Pundamilia_nyererei
ENSG00000124571	XPO5	96	78.082	ENSPNAG00000020035	si:ch211-233m11.2	99	65.271	Pygocentrus_nattereri
ENSG00000124571	XPO5	100	92.105	ENSRNOG00000019085	Xpo5	100	87.625	Rattus_norvegicus
ENSG00000124571	XPO5	100	99.502	ENSRBIG00000027492	XPO5	100	99.502	Rhinopithecus_bieti
ENSG00000124571	XPO5	100	99.336	ENSRROG00000030655	XPO5	100	99.336	Rhinopithecus_roxellana
ENSG00000124571	XPO5	100	98.256	ENSSBOG00000004763	XPO5	100	98.256	Saimiri_boliviensis_boliviensis
ENSG00000124571	XPO5	100	86.207	ENSSHAG00000014472	XPO5	100	86.289	Sarcophilus_harrisii
ENSG00000124571	XPO5	96	73.973	ENSSFOG00015005618	si:ch211-233m11.2	99	61.564	Scleropages_formosus
ENSG00000124571	XPO5	96	73.973	ENSSMAG00000001548	si:ch211-233m11.2	99	60.463	Scophthalmus_maximus
ENSG00000124571	XPO5	96	72.603	ENSSDUG00000009710	si:ch211-233m11.2	97	64.967	Seriola_dumerili
ENSG00000124571	XPO5	96	72.603	ENSSLDG00000020343	si:ch211-233m11.2	99	60.913	Seriola_lalandi_dorsalis
ENSG00000124571	XPO5	93	91.919	ENSSARG00000001349	XPO5	90	83.965	Sorex_araneus
ENSG00000124571	XPO5	96	72.603	ENSSPAG00000005659	si:ch211-233m11.2	99	60.248	Stegastes_partitus
ENSG00000124571	XPO5	100	96.053	ENSSSCG00000001679	XPO5	100	89.452	Sus_scrofa
ENSG00000124571	XPO5	92	91.837	ENSTGUG00000009168	XPO5	100	82.479	Taeniopygia_guttata
ENSG00000124571	XPO5	95	69.444	ENSTRUG00000012007	si:ch211-233m11.2	99	56.379	Takifugu_rubripes
ENSG00000124571	XPO5	96	69.863	ENSTNIG00000008658	si:ch211-233m11.2	99	56.882	Tetraodon_nigroviridis
ENSG00000124571	XPO5	100	97.368	ENSTBEG00000002808	XPO5	93	94.706	Tupaia_belangeri
ENSG00000124571	XPO5	100	95.266	ENSTTRG00000006347	XPO5	100	95.266	Tursiops_truncatus
ENSG00000124571	XPO5	93	97.980	ENSUMAG00000005928	XPO5	100	93.054	Ursus_maritimus
ENSG00000124571	XPO5	93	97.980	ENSVPAG00000004716	XPO5	100	83.675	Vicugna_pacos
ENSG00000124571	XPO5	100	97.368	ENSVVUG00000028952	XPO5	100	95.349	Vulpes_vulpes
ENSG00000124571	XPO5	96	57.534	ENSXETG00000003957	exd3	99	45.425	Xenopus_tropicalis
ENSG00000124571	XPO5	96	68.493	ENSXETG00000010883	xpo5	85	67.126	Xenopus_tropicalis
ENSG00000124571	XPO5	96	68.493	ENSXCOG00000013237	si:ch211-233m11.2	99	59.095	Xiphophorus_couchianus
ENSG00000124571	XPO5	91	61.856	ENSXMAG00000002870	si:ch211-233m11.2	98	58.235	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	-	TAS	Function
GO:0003729	mRNA binding	21297638.	IDA	Function
GO:0005049	nuclear export signal receptor activity	21873635.	IBA	Function
GO:0005049	nuclear export signal receptor activity	14681208.	IMP	Function
GO:0005515	protein binding	11777942.19124606.26878725.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11777942.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11777942.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006611	protein export from nucleus	11777942.24209753.	IDA	Process
GO:0008536	Ran GTPase binding	11777942.	IDA	Function
GO:0008536	Ran GTPase binding	14681208.20951941.	IPI	Function
GO:0008565	protein transporter activity	-	IEA	Function
GO:0010586	miRNA metabolic process	-	TAS	Process
GO:0035068	micro-ribonucleoprotein complex	19965479.	IDA	Component
GO:0035281	pre-miRNA export from nucleus	15613540.	IDA	Process
GO:0035281	pre-miRNA export from nucleus	14681208.	IMP	Process
GO:0035281	pre-miRNA export from nucleus	19965479.	NAS	Process
GO:0042272	nuclear RNA export factor complex	19965479.	IDA	Component
GO:0042565	RNA nuclear export complex	21873635.	IBA	Component
GO:0042565	RNA nuclear export complex	14681208.	IDA	Component
GO:0046825	regulation of protein export from nucleus	21873635.	IBA	Process
GO:0070883	pre-miRNA binding	21297638.	IDA	Function
GO:0070883	pre-miRNA binding	14681208.	IDA	Function
GO:0070883	pre-miRNA binding	19965479.	NAS	Function
GO:1900370	positive regulation of RNA interference	15613540.	IDA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.