EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19035462Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.Int J Cancer2009 Feb 15Liao YJdoi: 10.1002/ijc.23979.
12566309Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.Cancer Res2003 Feb 1Tseng TL-
21572396The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer.Mod Pathol2011 SepSong YHdoi: 10.1038/modpathol.2011.76
22850906Genetic factors regulating inflammation and DNA methylation associated with prostate cancer.Prostate Cancer Prostatic Dis2013 MarIanni Mdoi: 10.1038/pcan.2012.30
24800880Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study.PLoS One2014 May 6Chen Mdoi: 10.1371/journal.pone.0094683

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr6429637163'UTRnovel0.31
BLCAchr642962290SilentNAA95A0.36
BLCAchr642963142Silentrs752057158V174V0.19
BLCAchr642963205Missense_MutationnovelI195M0.46
BLCAchr642963161Missense_Mutationrs755100354D181N0.1
BRCAchr642963643SilentNAP275P0.15
CESCchr642963630Missense_MutationnovelG271D0.16
CESCchr642962300Missense_MutationnovelR99C0.37Methyltransf_31
COADchr642960915Missense_Mutationrs377704687L50I0.3
COADchr642962241Missense_MutationNAG79D0.23Methyltransf_31
GBMchr642963342SilentnovelK203K0.31
GBMchr6429637783'UTRnovel0.72
KIRCchr642962341Splice_SitenovelX112_splice0.47
KIRCchr642962227Frame_Shift_DelnovelM74Ifs*140.21Methyltransf_31
LIHCchr642963422Missense_MutationnovelA230D0.15
LIHCchr642963090Missense_Mutationrs563826316R157Q0.09Methyltransf_31
LIHCchr642960941SilentNAC58C0.48
LUADchr642962253Missense_MutationnovelT83K0.37Methyltransf_31
LUADchr642963160Silentrs147746130Y180Y0.11
LUADchr642963447Missense_MutationNAL238F0.22
LUSCchr642963152Missense_MutationNAR178C0.13Methyltransf_31
LUSCchr642963414SilentnovelV227V0.46
SKCMchr642963601Silentrs201991849F261F0.3
SKCMchr642963543Missense_Mutationrs199572656R242Q0.13
SKCMchr642963346Missense_Mutationrs758305053V205I0.41
SKCMchr642963112Silentrs149792195A164A0.27
STADchr642963542Missense_MutationnovelR242W0.15
STADchr642963686Missense_Mutationrs370220793V290M0.37
STADchr642963111Missense_Mutationrs768654043A164V0.2Methyltransf_31
STADchr642963086Missense_MutationNAH156Y0.44Methyltransf_31
STADchr642963379Missense_MutationNAA216T0.38
UCECchr6429637303'UTRnovel0.61
UCECchr642963626SilentNAL270L0.22
UCECchr642962325Missense_MutationnovelA107V0.41Methyltransf_31
UCECchr642963631SilentnovelG271G0.59
UCECchr642962766Silentrs759363288I113I0.43
UCECchr642962819Missense_MutationNAG131D0.29Methyltransf_31
UCECchr642962857Missense_Mutationrs776654469A144T0.46Methyltransf_31
UCECchr642962312Missense_Mutationrs749599022R103W0.41Methyltransf_31
UCECchr642962857Missense_Mutationrs776654469A144T0.32Methyltransf_31
UCECchr642963188Frame_Shift_DelnovelP191Qfs*110.3
UCECchr642962324Missense_Mutationrs535188125A107T0.12Methyltransf_31
UCECchr642963673SilentnovelC285C0.55

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
COADAMP0.17740.005341
READAMP0.27880.02906

Survival Analysis
CancerP-value Q-value
THYM0.0063

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.035

Kaplan-Meier Survival Analysis

UCS0.0059

Kaplan-Meier Survival Analysis

HNSC0.0034

Kaplan-Meier Survival Analysis

SKCM0.031

Kaplan-Meier Survival Analysis

LUSC0.019

Kaplan-Meier Survival Analysis

COAD0.0097

Kaplan-Meier Survival Analysis

BLCA0.012

Kaplan-Meier Survival Analysis

CESC0.00087

Kaplan-Meier Survival Analysis

KICH0.017

Kaplan-Meier Survival Analysis

UCEC0.018

Kaplan-Meier Survival Analysis

GBM0.045

Kaplan-Meier Survival Analysis

LIHC0.0012

Kaplan-Meier Survival Analysis

LUAD0.00011

Kaplan-Meier Survival Analysis

OV0.045

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000124713 (Gene tree)
Gene ID
27232
Gene Symbol
GNMT
Alias
-
Full Name
glycine N-methyltransferase
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
24,466 bases
Position
chr6:42,939,415-42,963,880
Accession
4415
RBP type
canonical RBP
Summary
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000361894Methyltransf_31PF13847.61.3e-0911
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000372808GNMT-2011072-ENSP00000361894295 (aa)-Q14749
Gene Model
Click here to download ENSG00000124713's gene model file
Pathways
Pathway IDPathway NameSource
hsa00260Glycine, serine and threonine metabolismKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124713's network
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000124713GNMT9974.403ENSAPOG00000019561gnmt9974.403Acanthochromis_polyacanthus
ENSG00000124713GNMT10094.576ENSAMEG00000012753GNMT10094.576Ailuropoda_melanoleuca
ENSG00000124713GNMT9974.315ENSACIG00000003441gnmt9974.315Amphilophus_citrinellus
ENSG00000124713GNMT9974.744ENSAOCG00000006298gnmt9974.744Amphiprion_ocellaris
ENSG00000124713GNMT9974.744ENSAPEG00000018396gnmt9974.744Amphiprion_percula
ENSG00000124713GNMT9973.720ENSATEG00000008278gnmt9773.720Anabas_testudineus
ENSG00000124713GNMT9979.932ENSACAG00000005587GNMT9979.932Anolis_carolinensis
ENSG00000124713GNMT10096.949ENSANAG00000021291GNMT10096.949Aotus_nancymaae
ENSG00000124713GNMT9973.630ENSACLG00000020588gnmt9973.630Astatotilapia_calliptera
ENSG00000124713GNMT9373.188ENSAMXG00000042907gnmt9973.188Astyanax_mexicanus
ENSG00000124713GNMT9992.517ENSBTAG00000051409-9992.517Bos_taurus
ENSG00000124713GNMT9992.857ENSBTAG00000051534GNMT9992.857Bos_taurus
ENSG00000124713GNMT10096.949ENSCJAG00000004675GNMT10096.949Callithrix_jacchus
ENSG00000124713GNMT9089.850ENSCAFG00000001741GNMT7889.850Canis_familiaris
ENSG00000124713GNMT10096.271ENSCAFG00020010607GNMT10096.271Canis_lupus_dingo
ENSG00000124713GNMT9993.857ENSCHIG00000026364GNMT9993.857Capra_hircus
ENSG00000124713GNMT9989.761ENSCPOG00000033341GNMT9989.761Cavia_porcellus
ENSG00000124713GNMT10096.610ENSCCAG00000035170GNMT10096.610Cebus_capucinus
ENSG00000124713GNMT10098.644ENSCATG00000032921GNMT10098.644Cercocebus_atys
ENSG00000124713GNMT10091.864ENSCLAG00000013521GNMT10091.864Chinchilla_lanigera
ENSG00000124713GNMT10098.644ENSCSAG00000011512GNMT10098.644Chlorocebus_sabaeus
ENSG00000124713GNMT9273.723ENSCPBG00000003801-9673.723Chrysemys_picta_bellii
ENSG00000124713GNMT10097.966ENSCANG00000034169GNMT10097.966Colobus_angolensis_palliatus
ENSG00000124713GNMT10093.559ENSCGRG00001020404Gnmt10093.559Cricetulus_griseus_chok1gshd
ENSG00000124713GNMT10093.559ENSCGRG00000015089Gnmt10093.559Cricetulus_griseus_crigri
ENSG00000124713GNMT9973.038ENSCSEG00000000109gnmt9973.038Cynoglossus_semilaevis
ENSG00000124713GNMT9972.696ENSCVAG00000009951gnmt9972.696Cyprinodon_variegatus
ENSG00000124713GNMT9972.542ENSDARG00000006840gnmt9972.542Danio_rerio
ENSG00000124713GNMT9957.045FBgn0038074Gnmt9757.045Drosophila_melanogaster
ENSG00000124713GNMT9341.304ENSEBUG00000007574-9841.304Eptatretus_burgeri
ENSG00000124713GNMT9967.628ENSEBUG00000011858gnmt9967.628Eptatretus_burgeri
ENSG00000124713GNMT9344.364ENSEBUG00000013162-9944.364Eptatretus_burgeri
ENSG00000124713GNMT10094.915ENSEASG00005003124GNMT10094.915Equus_asinus_asinus
ENSG00000124713GNMT10095.254ENSECAG00000017768GNMT10095.254Equus_caballus
ENSG00000124713GNMT9674.205ENSELUG00000019811gnmt9374.205Esox_lucius
ENSG00000124713GNMT10095.932ENSFCAG00000009711GNMT10095.932Felis_catus
ENSG00000124713GNMT8977.947ENSFALG00000000732GNMT9977.947Ficedula_albicollis
ENSG00000124713GNMT10091.864ENSFDAG00000020423GNMT10091.864Fukomys_damarensis
ENSG00000124713GNMT9970.608ENSGMOG00000010882gnmt9970.608Gadus_morhua
ENSG00000124713GNMT5282.237ENSGALG00000043290-8882.237Gallus_gallus
ENSG00000124713GNMT9973.720ENSGAFG00000001478gnmt9973.720Gambusia_affinis
ENSG00000124713GNMT9971.672ENSGACG00000005698gnmt9871.672Gasterosteus_aculeatus
ENSG00000124713GNMT7982.479ENSGAGG00000025685GNMT9982.479Gopherus_agassizii
ENSG00000124713GNMT100100.000ENSGGOG00000013572GNMT100100.000Gorilla_gorilla
ENSG00000124713GNMT9973.973ENSHBUG00000020847gnmt9973.973Haplochromis_burtoni
ENSG00000124713GNMT10091.525ENSHGLG00000017376GNMT10091.525Heterocephalus_glaber_female
ENSG00000124713GNMT10091.186ENSHGLG00100006220GNMT10091.186Heterocephalus_glaber_male
ENSG00000124713GNMT9972.696ENSHCOG00000014727gnmt9972.696Hippocampus_comes
ENSG00000124713GNMT9970.169ENSIPUG00000009695Gnmt9970.169Ictalurus_punctatus
ENSG00000124713GNMT10093.559ENSSTOG00000009464GNMT10093.559Ictidomys_tridecemlineatus
ENSG00000124713GNMT5295.395ENSJJAG00000001038-9295.395Jaculus_jaculus
ENSG00000124713GNMT9975.427ENSKMAG00000010405gnmt9975.427Kryptolebias_marmoratus
ENSG00000124713GNMT9973.379ENSLBEG00000019748gnmt9973.379Labrus_bergylta
ENSG00000124713GNMT9977.211ENSLACG00000008668GNMT9977.211Latimeria_chalumnae
ENSG00000124713GNMT9975.932ENSLOCG00000017179gnmt9976.271Lepisosteus_oculatus
ENSG00000124713GNMT10092.905ENSLAFG00000013861GNMT10092.905Loxodonta_africana
ENSG00000124713GNMT10098.644ENSMFAG00000045063GNMT10098.644Macaca_fascicularis
ENSG00000124713GNMT10098.644ENSMMUG00000001393GNMT10098.644Macaca_mulatta
ENSG00000124713GNMT10098.644ENSMNEG00000036639GNMT10098.644Macaca_nemestrina
ENSG00000124713GNMT10098.644ENSMLEG00000035798GNMT10098.644Mandrillus_leucophaeus
ENSG00000124713GNMT9973.973ENSMZEG00005006910gnmt9973.973Maylandia_zebra
ENSG00000124713GNMT9680.919ENSMGAG00000007120GNMT9980.919Meleagris_gallopavo
ENSG00000124713GNMT6994.702ENSMAUG00000016515Gnmt7294.702Mesocricetus_auratus
ENSG00000124713GNMT10094.237ENSMICG00000008225GNMT10094.237Microcebus_murinus
ENSG00000124713GNMT9973.379ENSMMOG00000002466gnmt9973.379Mola_mola
ENSG00000124713GNMT9889.583ENSMODG00000019018GNMT9889.583Monodelphis_domestica
ENSG00000124713GNMT9972.696ENSMALG00000010637gnmt9972.696Monopterus_albus
ENSG00000124713GNMT10092.203MGP_CAROLIEiJ_G0021685Gnmt10092.203Mus_caroli
ENSG00000124713GNMT10091.525ENSMUSG00000002769Gnmt10091.525Mus_musculus
ENSG00000124713GNMT10092.542MGP_PahariEiJ_G0020676Gnmt10092.542Mus_pahari
ENSG00000124713GNMT10091.864MGP_SPRETEiJ_G0022597Gnmt10091.864Mus_spretus
ENSG00000124713GNMT10096.271ENSMLUG00000012100GNMT10096.271Myotis_lucifugus
ENSG00000124713GNMT5295.395ENSNGAG00000013438-8495.395Nannospalax_galili
ENSG00000124713GNMT9973.288ENSNBRG00000010043gnmt9973.288Neolamprologus_brichardi
ENSG00000124713GNMT10098.644ENSNLEG00000030090GNMT10098.644Nomascus_leucogenys
ENSG00000124713GNMT9991.156ENSMEUG00000007821GNMT9991.156Notamacropus_eugenii
ENSG00000124713GNMT9972.603ENSONIG00000008264gnmt9972.603Oreochromis_niloticus
ENSG00000124713GNMT9994.218ENSOCUG00000003858GNMT9994.218Oryctolagus_cuniculus
ENSG00000124713GNMT9973.288ENSORLG00000023048gnmt9973.288Oryzias_latipes
ENSG00000124713GNMT9973.288ENSORLG00020017645gnmt9973.288Oryzias_latipes_hni
ENSG00000124713GNMT9972.945ENSORLG00015014146gnmt9972.945Oryzias_latipes_hsok
ENSG00000124713GNMT9973.379ENSOMEG00000012757gnmt9973.379Oryzias_melastigma
ENSG00000124713GNMT10095.254ENSOGAG00000012676GNMT10095.254Otolemur_garnettii
ENSG00000124713GNMT9993.174ENSOARG00000004327GNMT9593.174Ovis_aries
ENSG00000124713GNMT100100.000ENSPPAG00000000924GNMT100100.000Pan_paniscus
ENSG00000124713GNMT10095.593ENSPPRG00000023762GNMT10095.593Panthera_pardus
ENSG00000124713GNMT10095.593ENSPTIG00000021496GNMT10095.593Panthera_tigris_altaica
ENSG00000124713GNMT100100.000ENSPTRG00000018178GNMT100100.000Pan_troglodytes
ENSG00000124713GNMT10098.305ENSPANG00000022693GNMT10098.305Papio_anubis
ENSG00000124713GNMT9977.627ENSPKIG00000022265gnmt9182.143Paramormyrops_kingsleyae
ENSG00000124713GNMT7768.860ENSPSIG00000002397GNMT9968.860Pelodiscus_sinensis
ENSG00000124713GNMT9975.085ENSPMGG00000008397gnmt9975.085Periophthalmus_magnuspinnatus
ENSG00000124713GNMT9992.177ENSPEMG00000011330Gnmt9992.177Peromyscus_maniculatus_bairdii
ENSG00000124713GNMT9990.816ENSPCIG00000009285GNMT9990.816Phascolarctos_cinereus
ENSG00000124713GNMT9972.696ENSPFOG00000010483gnmt9972.696Poecilia_formosa
ENSG00000124713GNMT9972.696ENSPLAG00000007172gnmt9972.696Poecilia_latipinna
ENSG00000124713GNMT9972.696ENSPMEG00000024025gnmt9972.696Poecilia_mexicana
ENSG00000124713GNMT6788.500ENSPPYG00000016623-10088.500Pongo_abelii
ENSG00000124713GNMT10093.898ENSPCOG00000020942GNMT10093.898Propithecus_coquereli
ENSG00000124713GNMT10089.831ENSPVAG00000008702GNMT10089.831Pteropus_vampyrus
ENSG00000124713GNMT8871.429ENSPNYG00000004219gnmt8873.790Pundamilia_nyererei
ENSG00000124713GNMT9972.881ENSPNAG00000001905gnmt9972.881Pygocentrus_nattereri
ENSG00000124713GNMT9991.156ENSRNOG00000048623LOC1009115649991.156Rattus_norvegicus
ENSG00000124713GNMT9992.177ENSRNOG00000016349Gnmt9992.177Rattus_norvegicus
ENSG00000124713GNMT10097.627ENSRBIG00000044856GNMT10097.627Rhinopithecus_bieti
ENSG00000124713GNMT10097.627ENSRROG00000042667GNMT10097.627Rhinopithecus_roxellana
ENSG00000124713GNMT10096.949ENSSBOG00000023382GNMT10096.949Saimiri_boliviensis_boliviensis
ENSG00000124713GNMT9991.156ENSSHAG00000011595GNMT9991.156Sarcophilus_harrisii
ENSG00000124713GNMT9962.626ENSSFOG00015004123gnmt9962.626Scleropages_formosus
ENSG00000124713GNMT9974.315ENSSDUG00000013522gnmt9974.315Seriola_dumerili
ENSG00000124713GNMT9973.630ENSSLDG00000017480gnmt9973.630Seriola_lalandi_dorsalis
ENSG00000124713GNMT9983.333ENSSPUG00000018643GNMT9983.333Sphenodon_punctatus
ENSG00000124713GNMT9973.379ENSSPAG00000006015gnmt9973.379Stegastes_partitus
ENSG00000124713GNMT10094.576ENSSSCG00000033214GNMT9694.576Sus_scrofa
ENSG00000124713GNMT7278.873ENSTGUG00000005210GNMT9978.873Taeniopygia_guttata
ENSG00000124713GNMT5179.333ENSTRUG00000000840gnmt9979.333Takifugu_rubripes
ENSG00000124713GNMT9972.449ENSTNIG00000008896gnmt9972.449Tetraodon_nigroviridis
ENSG00000124713GNMT10094.576ENSTTRG00000006983GNMT10094.576Tursiops_truncatus
ENSG00000124713GNMT10095.932ENSUAMG00000017465GNMT10095.932Ursus_americanus
ENSG00000124713GNMT10096.271ENSVVUG00000027542GNMT10096.271Vulpes_vulpes
ENSG00000124713GNMT5176.000ENSXCOG00000013186gnmt9476.000Xiphophorus_couchianus
ENSG00000124713GNMT9971.331ENSXMAG00000000189gnmt9971.331Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005515protein binding16189514.21988832.26871637.IPIFunction
GO:0005542folic acid binding-IEAFunction
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005977glycogen metabolic process-IEAProcess
GO:0006111regulation of gluconeogenesis21873635.IBAProcess
GO:0006464cellular protein modification process10843803.NASProcess
GO:0006555methionine metabolic process-IEAProcess
GO:0006730one-carbon metabolic process21873635.IBAProcess
GO:0016594glycine binding21873635.IBAFunction
GO:0016594glycine binding15340920.IDAFunction
GO:0017174glycine N-methyltransferase activity21873635.IBAFunction
GO:0017174glycine N-methyltransferase activity15340920.IDAFunction
GO:0032259methylation-IEAProcess
GO:0034641cellular nitrogen compound metabolic process-TASProcess
GO:0042802identical protein binding21873635.IBAFunction
GO:0042802identical protein binding16189514.26871637.IPIFunction
GO:0046498S-adenosylhomocysteine metabolic process21873635.IBAProcess
GO:0046500S-adenosylmethionine metabolic process21873635.IBAProcess
GO:0046500S-adenosylmethionine metabolic process15340920.IDAProcess
GO:0051289protein homotetramerization21873635.IBAProcess
GO:0051289protein homotetramerization15340920.IPIProcess
GO:1901052sarcosine metabolic process21873635.IBAProcess
GO:1904047S-adenosyl-L-methionine binding21873635.IBAFunction
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