EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21663673	Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer.	BMC Cancer	2011 Jun 10	Datta A	doi: 10.1186/1471-2407-11-234.
28670979	DEK proto-oncogene is highly expressed in astrocytic tumors and regulates glioblastoma cell proliferation and apoptosis.	Tumour Biol	2017 Jul	Feng T	doi: 10.1177/1010428317716248.
20543864	DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung.	Oncogene	2010 Aug 19	Shibata T	doi: 10.1038/onc.2010.217
16721057	DEK Expression is controlled by E2F and deregulated in diverse tumor types.	Cell Cycle	2006 Jun	Carro MS	-
30412857	The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival.	Neoplasia	2018 Dec	Hacker KE	doi: 10.1016/j.neo.2018.10.005
16254365	The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.	J Virol	2005 Nov	Wise-Draper TM	-
21317931	The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.	Oncogene	2011 Jun 16	Privette Vinnedge LM	doi: 10.1038/onc.2011.2
24954505	The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.	Oncogene	2015 Apr 30	Privette Vinnedge LM	doi: 10.1038/onc.2014.173
25197373	High expression of oncoprotein DEK predicts poor prognosis of small cell lung cancer.	Int J Clin Exp Pathol	2014 Jul 15	Wang X	-
25515240	DEK is a potential marker for aggressive phenotype and irinotecan-based therapy response in metastatic colorectal cancer.	BMC Cancer	2014 Dec 16	Martinez-Useros J	doi: 10.1186/1471-2407-14-965.
23571382	DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer.	J Histochem Cytochem	2013 Jul	Wang J	doi: 10.1369/0022155413488120
25340858	Mechanisms underlying cancer growth and apoptosis by DEK overexpression in colorectal cancer.	PLoS One	2014 Oct 23	Lin L	doi: 10.1371/journal.pone.0111260
23071688	The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.	PLoS One	2012	Privette Vinnedge LM	doi: 10.1371/journal.pone.0046985
24650035	High expression of DEK predicts poor prognosis of gastric adenocarcinoma.	Diagn Pathol	2014 Mar 20	Piao J	doi: 10.1186/1746-1596-9-67.
22360505	DEK overexpression is correlated with the clinical features of breast cancer.	Pathol Int	2012 Mar	Liu S	doi: 10.1111/j.1440-1827.2011.02775.x
28558019	Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis.	PLoS One	2017 May 30	Matrka MC	doi: 10.1371/journal.pone.0177952
26988756	The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.	Oncotarget	2016 Apr 26	Zhang Y	doi: 10.18632/oncotarget.8060.
28765911	LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells.	Mol Med Rep	2017 Oct	Xu Y	doi: 10.3892/mmr.2017.7095
28627610	Silencing DEK downregulates cervical cancer tumorigenesis and metastasis via the DEK/p-Ser9-GSK-3β/p-Tyr216-GSK-3β/β-catenin axis.	Oncol Rep	2017 Aug	Xu X	doi: 10.3892/or.2017.5721

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	18237494	Missense_Mutation	novel	R262T	0.1
BLCA	chr6	18264464	5'UTR	novel		0.45
BLCA	chr6	18249671	Missense_Mutation	NA	D248H	0.21
BLCA	chr6	18263963	Missense_Mutation	rs755415804	E9K	0.33
BLCA	chr6	18237454	In_Frame_Ins	novel	K275delinsNTMYNILIYAI	0.14
BLCA	chr6	18255771	Missense_Mutation	NA	R178T	0.06
BRCA	chr6	18236595	Missense_Mutation	NA	E302K	0.34
BRCA	chr6	18249713	Missense_Mutation	NA	E234K	0.23
BRCA	chr6	18225437	3'UTR	novel		0.67
BRCA	chr6	18237430	Frame_Shift_Del	novel	*A285Qfs28**	0.19
CESC	chr6	18255770	Silent	novel	R178R	0.27
CESC	chr6	18224805	3'UTR	novel		0.5
CESC	chr6	18226209	Missense_Mutation	novel	E361K	0.07
CESC	chr6	18236595	Missense_Mutation	NA	E302Q	0.24
CESC	chr6	18225591	3'UTR	novel		0.32
COAD	chr6	18258019	Frame_Shift_Del	NA	L98*	0.41	SAP
COAD	chr6	18263957	Frame_Shift_Del	novel	*E11Rfs53**	0.4
COAD	chr6	18226177	Frame_Shift_Del	novel	*E372Sfs2**	0.2
COAD	chr6	18225572	3'UTR	novel		0.12
COAD	chr6	18256402	Frame_Shift_Del	NA	*G138Efs12**	0.36
COAD	chr6	18255780	Missense_Mutation	novel	L175R	0.33
COAD	chr6	18236502	Silent	novel	L333L	0.32
COAD	chr6	18249831	Silent	rs769074388	P194P	0.35
COAD	chr6	18255828	Missense_Mutation	NA	S159N	0.24
DLBC	chr6	18249663	Missense_Mutation	NA	E250D	0.36
ESCA	chr6	18255748	Missense_Mutation	novel	P186A	0.09
GBM	chr6	18256385	Missense_Mutation	novel	K143T	0.06
GBM	chr6	18225588	3'UTR	novel		0.78
GBM	chr6	18256439	Missense_Mutation	novel	K125R	0.14
GBM	chr6	18225674	3'UTR	novel		0.14
GBM	chr6	18256362	Missense_Mutation	novel	K151Q	0.07
HNSC	chr6	18263957	Frame_Shift_Del	novel	*E11Rfs53**	0.3
HNSC	chr6	18263997	Splice_Site	novel		0.12
HNSC	chr6	18263998	Splice_Region	novel		0.1
HNSC	chr6	18263929	Missense_Mutation	novel	E20V	0.31
LGG	chr6	18236573	Missense_Mutation	NA	D309A	0.11
LGG	chr6	18255766	Frame_Shift_Ins	novel	*L180Rfs6**	0.08
LIHC	chr6	18258372	Nonsense_Mutation	novel	*K60delinsILGIYDSNLQ*	0.03
LIHC	chr6	18258349	Missense_Mutation	rs147997771	M68V	0.32
LIHC	chr6	18249687	Silent	NA	E242E	0.07
LUAD	chr6	18236591	Missense_Mutation	NA	S303C	0.1
LUAD	chr6	18225648	3'UTR	novel		0.14
LUAD	chr6	18249806	Missense_Mutation	NA	G203C	0.34
LUAD	chr6	18258327	Missense_Mutation	NA	R75T	0.11
LUAD	chr6	18249798	Silent	novel	K205K	0.25
LUAD	chr6	18263840	Splice_Site	novel	X49_splice	0.22
LUSC	chr6	18225590	3'UTR	novel		0.26
OV	chr6	18258400	Frame_Shift_Ins	novel	*S51Efs15**	0.05
OV	chr6	18258402	Missense_Mutation	novel	K50M	0.01
OV	chr6	18236598	Missense_Mutation	novel	S301G	0.11
OV	chr6	18263971	Missense_Mutation	NA	P6R	0.3
OV	chr6	18225481	3'UTR	novel		0.13
OV	chr6	18236598	Frame_Shift_Del	novel	*S301Vfs12**	0.15
PAAD	chr6	18257985	Missense_Mutation	novel	L109V	0.2	SAP
PAAD	chr6	18236506	Frame_Shift_Del	novel	*K330Nfs13**	0.18
PAAD	chr6	18225593	3'UTR	novel		0.19
PRAD	chr6	18258319	Missense_Mutation	NA	F78V	0.24
READ	chr6	18225630	3'UTR	novel		0.43
SKCM	chr6	18237414	Missense_Mutation	novel	T289A	0.39
SKCM	chr6	18255851	Splice_Region	rs755361234	K151K	0.36
SKCM	chr6	18264552	5'UTR	novel		0.33
SKCM	chr6	18225588	3'UTR	novel		0.24
SKCM	chr6	18264552	5'UTR	novel		0.31
SKCM	chr6	18258397	Missense_Mutation	NA	L52F	0.28
SKCM	chr6	18256401	Missense_Mutation	novel	G138R	0.33
STAD	chr6	18258384	Missense_Mutation	novel	G56D	0.05
STAD	chr6	18264497	5'UTR	novel		0.6
STAD	chr6	18263982	Silent	novel	S2S	0.1
STAD	chr6	18256455	Missense_Mutation	NA	V120M	0.35
STAD	chr6	18257954	Missense_Mutation	rs754580267	T119I	0.39
STAD	chr6	18225605	3'UTR	novel		0.1
STAD	chr6	18237416	Missense_Mutation	NA	S288T	0.21
STAD	chr6	18258364	Frame_Shift_Ins	novel	*V63Sfs28**	0.26
STAD	chr6	18237382	Frame_Shift_Del	novel	*E300Kfs13**	0.32
STAD	chr6	18237416	Missense_Mutation	NA	S288T	0.87
UCEC	chr6	18226200	Missense_Mutation	NA	D364Y	0.32
UCEC	chr6	18249663	Missense_Mutation	NA	E250D	0.23
UCEC	chr6	18263924	Nonsense_Mutation	novel	E22*	0.41
UCEC	chr6	18237453	Frame_Shift_Ins	novel	*S276Ifs8**	0.38
UCEC	chr6	18256430	Missense_Mutation	novel	G128D	0.45
UCEC	chr6	18263865	Missense_Mutation	rs147127829	E41D	0.42
UCEC	chr6	18225646	3'UTR	novel		0.29
UCEC	chr6	18263881	Missense_Mutation	novel	E36A	0.16
UCEC	chr6	18236512	Missense_Mutation	rs778323884	I329M	0.53
UCEC	chr6	18224855	3'UTR	novel		0.52
UCEC	chr6	18237496	Silent	novel	K261K	0.37
UCEC	chr6	18236552	Missense_Mutation	novel	L316S	0.24
UCEC	chr6	18258034	Silent	novel	E92E	0.3
UCEC	chr6	18263939	Missense_Mutation	novel	P17S	0.43
UCEC	chr6	18237383	Missense_Mutation	novel	K299I	0.36
UCEC	chr6	18237457	Missense_Mutation	novel	K274N	0.05
UCEC	chr6	18225664	3'UTR	novel		0.26
UCEC	chr6	18255771	Missense_Mutation	novel	R178M	0.39
UCEC	chr6	18249817	Frame_Shift_Ins	novel	*T199Nfs3**	0.26
UCEC	chr6	18237488	Missense_Mutation	novel	K264T	0.34
UCEC	chr6	18224804	3'UTR	novel		0.47
UCEC	chr6	18225437	3'UTR	novel		0.29
UCEC	chr6	18226231	Missense_Mutation	novel	N353K	0.39
UCEC	chr6	18256401	Nonsense_Mutation	NA	G138*	0.18
UCEC	chr6	18237382	Frame_Shift_Del	novel	*E300Kfs13**	0.32
UCEC	chr6	18225437	3'UTR	novel		0.5
UCEC	chr6	18225486	3'UTR	novel		0.33
UCEC	chr6	18237416	Missense_Mutation	NA	S288T	0.28
UCEC	chr6	18237382	Splice_Region	novel	K299K	0.31
UCEC	chr6	18226222	Silent	NA	T356T	0.5
UCEC	chr6	18249657	Missense_Mutation	NA	E252D	0.48
UCEC	chr6	18256360	Frame_Shift_Ins	novel	*F152Ifs2**	0.06
UCEC	chr6	18258304	Nonsense_Mutation	novel	G83*	0.3	SAP
UCEC	chr6	18263943	Silent	novel	T15T	0.25
UCEC	chr6	18236509	Missense_Mutation	novel	K330N	0.29
UCEC	chr6	18249831	Silent	rs769074388	P194P	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1778	0.19267
CESC	DEL	0.1288	0.046699
PAAD	DEL	0.288	0.00010152
SARC	DEL	0.2412	0.014376
UVM	AMP	0.55	2.0409e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.011	Kaplan-Meier Survival Analysis
KIRC	0.004	Kaplan-Meier Survival Analysis
SARC	0.006	Kaplan-Meier Survival Analysis
MESO	0.0036	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.029	Kaplan-Meier Survival Analysis
SKCM	0.00019	Kaplan-Meier Survival Analysis
PRAD	0.022	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0052	Kaplan-Meier Survival Analysis
PCPG	0.014	Kaplan-Meier Survival Analysis
READ	0.0022	Kaplan-Meier Survival Analysis
KICH	0.0064	Kaplan-Meier Survival Analysis
UCEC	0.022	Kaplan-Meier Survival Analysis
LIHC	0.0025	Kaplan-Meier Survival Analysis
LGG	0.0014	Kaplan-Meier Survival Analysis
OV	0.0031	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000124795 (Gene tree)
Gene ID: 7913
Gene Symbol: DEK
Alias: D6S231E
Full Name: DEK proto-oncogene
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 40,956 bases
Position: chr6:18,223,868-18,264,823
Accession: 2768
RBP type: canonical RBP
Summary: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000425399	SAP	PF02037.27	4.6e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16603771	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.	J Biol Chem	2006 Jun 16	Cavellan E	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397239	DEK-202	3427	XM_017011273	ENSP00000380414	375 (aa)	XP_016866762	P35659
ENST00000503715	DEK-203	580	-	ENSP00000425399	122 (aa)	-	D6RDA2
ENST00000505224	DEK-204	1372	-	ENSP00000421165	347 (aa)	-	B4DFG0
ENST00000244776	DEK-201	1441	-	ENSP00000244776	341 (aa)	-	P35659
ENST00000507591	DEK-205	739	-	ENSP00000423427	156 (aa)	-	H0Y993
ENST00000512145	DEK-206	791	-	-	- (aa)	-	-
ENST00000515742	DEK-207	661	-	ENSP00000423553	151 (aa)	-	D6R9L5
ENST00000515770	DEK-208	2895	-	ENSP00000422380	285 (aa)	-	H0Y8X0

Gene Model

Click here to download ENSG00000124795's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000124795	thiopurine methyltransferase	5E-34	27770449

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124795's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21653549.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	9050861.	TAS	Process
GO:0007165	signal transduction	9050861.	TAS	Process
GO:0019079	viral genome replication	9050861.	TAS	Process
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042393	histone binding	12140263.	IDA	Function
GO:0043292	contractile fiber	-	IEA	Component
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	Process
GO:2000779	regulation of double-strand break repair	21873635.	IBA	Process
GO:2000779	regulation of double-strand break repair	21653549.	IMP	Process
GO:2001032	regulation of double-strand break repair via nonhomologous end joining	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.