EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21663673Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer.BMC Cancer2011 Jun 10Datta Adoi: 10.1186/1471-2407-11-234.
28670979DEK proto-oncogene is highly expressed in astrocytic tumors and regulates glioblastoma cell proliferation and apoptosis.Tumour Biol2017 JulFeng Tdoi: 10.1177/1010428317716248.
20543864DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung.Oncogene2010 Aug 19Shibata Tdoi: 10.1038/onc.2010.217
16721057DEK Expression is controlled by E2F and deregulated in diverse tumor types.Cell Cycle2006 JunCarro MS-
30412857The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival.Neoplasia2018 DecHacker KEdoi: 10.1016/j.neo.2018.10.005
16254365The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.J Virol2005 NovWise-Draper TM-
21317931The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.Oncogene2011 Jun 16Privette Vinnedge LMdoi: 10.1038/onc.2011.2
24954505The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.Oncogene2015 Apr 30Privette Vinnedge LMdoi: 10.1038/onc.2014.173
25197373High expression of oncoprotein DEK predicts poor prognosis of small cell lung cancer.Int J Clin Exp Pathol2014 Jul 15Wang X-
25515240DEK is a potential marker for aggressive phenotype and irinotecan-based therapy response in metastatic colorectal cancer.BMC Cancer2014 Dec 16Martinez-Useros Jdoi: 10.1186/1471-2407-14-965.
23571382DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer.J Histochem Cytochem2013 JulWang Jdoi: 10.1369/0022155413488120
25340858Mechanisms underlying cancer growth and apoptosis by DEK overexpression in colorectal cancer.PLoS One2014 Oct 23Lin Ldoi: 10.1371/journal.pone.0111260
23071688The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.PLoS One2012Privette Vinnedge LMdoi: 10.1371/journal.pone.0046985
24650035High expression of DEK predicts poor prognosis of gastric adenocarcinoma.Diagn Pathol2014 Mar 20Piao Jdoi: 10.1186/1746-1596-9-67.
22360505DEK overexpression is correlated with the clinical features of breast cancer.Pathol Int2012 MarLiu Sdoi: 10.1111/j.1440-1827.2011.02775.x
28558019Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis.PLoS One2017 May 30Matrka MCdoi: 10.1371/journal.pone.0177952
26988756The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.Oncotarget2016 Apr 26Zhang Ydoi: 10.18632/oncotarget.8060.
28765911LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells.Mol Med Rep2017 OctXu Ydoi: 10.3892/mmr.2017.7095
28627610Silencing DEK downregulates cervical cancer tumorigenesis and metastasis via the DEK/p-Ser9-GSK-3β/p-Tyr216-GSK-3β/β-catenin axis.Oncol Rep2017 AugXu Xdoi: 10.3892/or.2017.5721

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr618237494Missense_MutationnovelR262T0.1
BLCAchr6182644645'UTRnovel0.45
BLCAchr618249671Missense_MutationNAD248H0.21
BLCAchr618263963Missense_Mutationrs755415804E9K0.33
BLCAchr618237454In_Frame_InsnovelK275delinsNTMYNILIYAI0.14
BLCAchr618255771Missense_MutationNAR178T0.06
BRCAchr618236595Missense_MutationNAE302K0.34
BRCAchr618249713Missense_MutationNAE234K0.23
BRCAchr6182254373'UTRnovel0.67
BRCAchr618237430Frame_Shift_DelnovelA285Qfs*280.19
CESCchr618255770SilentnovelR178R0.27
CESCchr6182248053'UTRnovel0.5
CESCchr618226209Missense_MutationnovelE361K0.07
CESCchr618236595Missense_MutationNAE302Q0.24
CESCchr6182255913'UTRnovel0.32
COADchr618258019Frame_Shift_DelNAL98*0.41SAP
COADchr618263957Frame_Shift_DelnovelE11Rfs*530.4
COADchr618226177Frame_Shift_DelnovelE372Sfs*20.2
COADchr6182255723'UTRnovel0.12
COADchr618256402Frame_Shift_DelNAG138Efs*120.36
COADchr618255780Missense_MutationnovelL175R0.33
COADchr618236502SilentnovelL333L0.32
COADchr618249831Silentrs769074388P194P0.35
COADchr618255828Missense_MutationNAS159N0.24
DLBCchr618249663Missense_MutationNAE250D0.36
ESCAchr618255748Missense_MutationnovelP186A0.09
GBMchr618256385Missense_MutationnovelK143T0.06
GBMchr6182255883'UTRnovel0.78
GBMchr618256439Missense_MutationnovelK125R0.14
GBMchr6182256743'UTRnovel0.14
GBMchr618256362Missense_MutationnovelK151Q0.07
HNSCchr618263957Frame_Shift_DelnovelE11Rfs*530.3
HNSCchr618263997Splice_Sitenovel0.12
HNSCchr618263998Splice_Regionnovel0.1
HNSCchr618263929Missense_MutationnovelE20V0.31
LGGchr618236573Missense_MutationNAD309A0.11
LGGchr618255766Frame_Shift_InsnovelL180Rfs*60.08
LIHCchr618258372Nonsense_MutationnovelK60delinsIL*GI*YDSNLQ0.03
LIHCchr618258349Missense_Mutationrs147997771M68V0.32
LIHCchr618249687SilentNAE242E0.07
LUADchr618236591Missense_MutationNAS303C0.1
LUADchr6182256483'UTRnovel0.14
LUADchr618249806Missense_MutationNAG203C0.34
LUADchr618258327Missense_MutationNAR75T0.11
LUADchr618249798SilentnovelK205K0.25
LUADchr618263840Splice_SitenovelX49_splice0.22
LUSCchr6182255903'UTRnovel0.26
OVchr618258400Frame_Shift_InsnovelS51Efs*150.05
OVchr618258402Missense_MutationnovelK50M0.01
OVchr618236598Missense_MutationnovelS301G0.11
OVchr618263971Missense_MutationNAP6R0.3
OVchr6182254813'UTRnovel0.13
OVchr618236598Frame_Shift_DelnovelS301Vfs*120.15
PAADchr618257985Missense_MutationnovelL109V0.2SAP
PAADchr618236506Frame_Shift_DelnovelK330Nfs*130.18
PAADchr6182255933'UTRnovel0.19
PRADchr618258319Missense_MutationNAF78V0.24
READchr6182256303'UTRnovel0.43
SKCMchr618237414Missense_MutationnovelT289A0.39
SKCMchr618255851Splice_Regionrs755361234K151K0.36
SKCMchr6182645525'UTRnovel0.33
SKCMchr6182255883'UTRnovel0.24
SKCMchr6182645525'UTRnovel0.31
SKCMchr618258397Missense_MutationNAL52F0.28
SKCMchr618256401Missense_MutationnovelG138R0.33
STADchr618258384Missense_MutationnovelG56D0.05
STADchr6182644975'UTRnovel0.6
STADchr618263982SilentnovelS2S0.1
STADchr618256455Missense_MutationNAV120M0.35
STADchr618257954Missense_Mutationrs754580267T119I0.39
STADchr6182256053'UTRnovel0.1
STADchr618237416Missense_MutationNAS288T0.21
STADchr618258364Frame_Shift_InsnovelV63Sfs*280.26
STADchr618237382Frame_Shift_DelnovelE300Kfs*130.32
STADchr618237416Missense_MutationNAS288T0.87
UCECchr618226200Missense_MutationNAD364Y0.32
UCECchr618249663Missense_MutationNAE250D0.23
UCECchr618263924Nonsense_MutationnovelE22*0.41
UCECchr618237453Frame_Shift_InsnovelS276Ifs*80.38
UCECchr618256430Missense_MutationnovelG128D0.45
UCECchr618263865Missense_Mutationrs147127829E41D0.42
UCECchr6182256463'UTRnovel0.29
UCECchr618263881Missense_MutationnovelE36A0.16
UCECchr618236512Missense_Mutationrs778323884I329M0.53
UCECchr6182248553'UTRnovel0.52
UCECchr618237496SilentnovelK261K0.37
UCECchr618236552Missense_MutationnovelL316S0.24
UCECchr618258034SilentnovelE92E0.3
UCECchr618263939Missense_MutationnovelP17S0.43
UCECchr618237383Missense_MutationnovelK299I0.36
UCECchr618237457Missense_MutationnovelK274N0.05
UCECchr6182256643'UTRnovel0.26
UCECchr618255771Missense_MutationnovelR178M0.39
UCECchr618249817Frame_Shift_InsnovelT199Nfs*30.26
UCECchr618237488Missense_MutationnovelK264T0.34
UCECchr6182248043'UTRnovel0.47
UCECchr6182254373'UTRnovel0.29
UCECchr618226231Missense_MutationnovelN353K0.39
UCECchr618256401Nonsense_MutationNAG138*0.18
UCECchr618237382Frame_Shift_DelnovelE300Kfs*130.32
UCECchr6182254373'UTRnovel0.5
UCECchr6182254863'UTRnovel0.33
UCECchr618237416Missense_MutationNAS288T0.28
UCECchr618237382Splice_RegionnovelK299K0.31
UCECchr618226222SilentNAT356T0.5
UCECchr618249657Missense_MutationNAE252D0.48
UCECchr618256360Frame_Shift_InsnovelF152Ifs*20.06
UCECchr618258304Nonsense_MutationnovelG83*0.3SAP
UCECchr618263943SilentnovelT15T0.25
UCECchr618236509Missense_MutationnovelK330N0.29
UCECchr618249831Silentrs769074388P194P0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.17780.19267
CESCDEL0.12880.046699
PAADDEL0.2880.00010152
SARCDEL0.24120.014376
UVMAMP0.552.0409e-06

Survival Analysis
CancerP-value Q-value
THYM0.011

Kaplan-Meier Survival Analysis

KIRC0.004

Kaplan-Meier Survival Analysis

SARC0.006

Kaplan-Meier Survival Analysis

MESO0.0036

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

UCS0.029

Kaplan-Meier Survival Analysis

SKCM0.00019

Kaplan-Meier Survival Analysis

PRAD0.022

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

PAAD0.0052

Kaplan-Meier Survival Analysis

PCPG0.014

Kaplan-Meier Survival Analysis

READ0.0022

Kaplan-Meier Survival Analysis

KICH0.0064

Kaplan-Meier Survival Analysis

UCEC0.022

Kaplan-Meier Survival Analysis

LIHC0.0025

Kaplan-Meier Survival Analysis

LGG0.0014

Kaplan-Meier Survival Analysis

OV0.0031

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000124795 (Gene tree)
Gene ID
7913
Gene Symbol
DEK
Alias
D6S231E
Full Name
DEK proto-oncogene
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
40,956 bases
Position
chr6:18,223,868-18,264,823
Accession
2768
RBP type
canonical RBP
Summary
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000425399SAPPF02037.274.6e-0611
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16603771The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.J Biol Chem2006 Jun 16Cavellan E-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000397239DEK-2023427XM_017011273ENSP00000380414375 (aa)XP_016866762P35659
ENST00000503715DEK-203580-ENSP00000425399122 (aa)-D6RDA2
ENST00000505224DEK-2041372-ENSP00000421165347 (aa)-B4DFG0
ENST00000244776DEK-2011441-ENSP00000244776341 (aa)-P35659
ENST00000507591DEK-205739-ENSP00000423427156 (aa)-H0Y993
ENST00000512145DEK-206791--- (aa)--
ENST00000515742DEK-207661-ENSP00000423553151 (aa)-D6R9L5
ENST00000515770DEK-2082895-ENSP00000422380285 (aa)-H0Y8X0
Gene Model
Click here to download ENSG00000124795's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000124795thiopurine methyltransferase5E-3427770449
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124795's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003677DNA binding-IEAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus21653549.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006325chromatin organization-IEAProcess
GO:0006357regulation of transcription by RNA polymerase II-TASProcess
GO:0006366transcription by RNA polymerase II9050861.TASProcess
GO:0007165signal transduction9050861.TASProcess
GO:0019079viral genome replication9050861.TASProcess
GO:0042393histone binding21873635.IBAFunction
GO:0042393histone binding12140263.IDAFunction
GO:0043292contractile fiber-IEAComponent
GO:0045815positive regulation of gene expression, epigenetic-TASProcess
GO:2000779regulation of double-strand break repair21873635.IBAProcess
GO:2000779regulation of double-strand break repair21653549.IMPProcess
GO:2001032regulation of double-strand break repair via nonhomologous end joining-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us