EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr16	58708244	Missense_Mutation	novel	R407H	0.3
ACC	chr16	58734209	Missense_Mutation	novel	G7V	0.34
BLCA	chr16	58722162	Silent	novel	L121L	0.33
BLCA	chr16	58723743	Splice_Region	rs759931275		0.49
BRCA	chr16	58708155	3'UTR	novel		0.47
BRCA	chr16	58708137	3'UTR	novel		0.23
BRCA	chr16	58708251	Missense_Mutation	NA	D405H	0.28
CESC	chr16	58723888	Missense_Mutation	novel	H35R	0.31
CESC	chr16	58734166	Silent	NA	L21L	0.1
CESC	chr16	58718655	Missense_Mutation	NA	L157V	0.19
COAD	chr16	58716047	Missense_Mutation	NA	A329V	0.21
COAD	chr16	58716144	Missense_Mutation	novel	D297N	0.07
COAD	chr16	58722244	Missense_Mutation	novel	K94R	0.17
COAD	chr16	58708158	3'UTR	rs374778384		0.36
COAD	chr16	58722252	Missense_Mutation	NA	N91K	0.45
COAD	chr16	58716797	Missense_Mutation	rs754471368	A240V	0.32
COAD	chr16	58716012	Splice_Site	NA	X340_splice	0.53
COAD	chr16	58716796	Silent	rs758265732	A240A	0.25
GBM	chr16	58718270	Missense_Mutation	novel	H210Y	0.07
GBM	chr16	58718645	Missense_Mutation	novel	P160Q	0.03
HNSC	chr16	58718295	Missense_Mutation	novel	I201M	0.12
HNSC	chr16	58723815	Missense_Mutation	novel	K59N	0.22
HNSC	chr16	58708133	3'UTR	novel		0.11
HNSC	chr16	58708094	3'UTR	novel		0.33
KIRC	chr16	58709421	Missense_Mutation	NA	E389G	0.19
KIRC	chr16	58718270	Missense_Mutation	novel	H210N	0.04
KIRC	chr16	58723810	Missense_Mutation	rs199949591	N61S	0.2
KIRP	chr16	58708192	Frame_Shift_Del	novel	*I425Ffs32**	0.53
LAML	chr16	58716743	Missense_Mutation	novel	A258V	0.11
LAML	chr16	58718230	Missense_Mutation	rs762925421	P223L	0.09
LUAD	chr16	58723859	Silent	novel	L45L	0.06
LUAD	chr16	58722246	Missense_Mutation	novel	D93E	0.15
LUAD	chr16	58716791	Missense_Mutation	novel	F242S	0.3
LUAD	chr16	58718679	Missense_Mutation	NA	F149V	0.19
LUAD	chr16	58718285	Missense_Mutation	NA	S205C	0.21
LUAD	chr16	58718276	Missense_Mutation	novel	L208F	0.09
LUAD	chr16	58722260	Missense_Mutation	rs137905758	A89S	0.17
LUSC	chr16	58716681	Missense_Mutation	NA	K279E	0.32
LUSC	chr16	58709473	Missense_Mutation	NA	Q372K	0.4
LUSC	chr16	58709542	Missense_Mutation	novel	D349Y	0.37
LUSC	chr16	58718541	Missense_Mutation	novel	V195L	0.27
LUSC	chr16	58723868	Missense_Mutation	novel	D42N	0.14
LUSC	chr16	58716798	Missense_Mutation	NA	A240S	0.2
LUSC	chr16	58708159	3'UTR	novel		0.66
PRAD	chr16	58718204	Missense_Mutation	novel	V232M	0.13
SKCM	chr16	58716074	Missense_Mutation	NA	P320L	0.47
SKCM	chr16	58716721	Silent	NA	I265I	0.2
SKCM	chr16	58723751	Missense_Mutation	rs201744006	R81C	0.22
SKCM	chr16	58734194	Missense_Mutation	NA	G12E	0.94
SKCM	chr16	58723874	Missense_Mutation	novel	P40S	0.14
SKCM	chr16	58722187	Missense_Mutation	NA	A113V	0.8
SKCM	chr16	58716062	Missense_Mutation	NA	A324V	0.14
SKCM	chr16	58719231	Nonsense_Mutation	NA	G134*	0.17
SKCM	chr16	58716721	Silent	NA	I265I	0.28
SKCM	chr16	58708155	3'UTR	novel		0.19
SKCM	chr16	58716092	Missense_Mutation	NA	P314L	0.57
SKCM	chr16	58723864	Missense_Mutation	NA	P43L	0.34
STAD	chr16	58716732	Missense_Mutation	rs752927520	R262C	0.09
STAD	chr16	58723754	Missense_Mutation	rs537935734	V80I	0.23
STAD	chr16	58718539	Silent	NA	V195V	0.4
STAD	chr16	58734271	5'UTR	novel		0.31
THCA	chr16	58716173	Missense_Mutation	NA	R287L	0.3
UCEC	chr16	58716732	Missense_Mutation	rs752927520	R262C	0.3
UCEC	chr16	58718261	Missense_Mutation	novel	A213T	0.19
UCEC	chr16	58718247	Silent	rs181076765	T217T	0.2
UCEC	chr16	58708012	3'UTR	novel		0.45
UCEC	chr16	58723763	Missense_Mutation	novel	L77M	0.18
UCEC	chr16	58723767	Silent	rs780937861	Y75Y	0.21
UCEC	chr16	58716024	Nonsense_Mutation	NA	R337*	0.33
UCEC	chr16	58719243	Nonsense_Mutation	novel	Q130*	0.38
UCEC	chr16	58707924	3'UTR	novel		0.28
UCEC	chr16	58718269	Missense_Mutation	NA	H210R	0.43
UCEC	chr16	58722244	Missense_Mutation	novel	K94R	0.25
UCEC	chr16	58709524	Missense_Mutation	NA	R355G	0.49
UCEC	chr16	58708287	Missense_Mutation	rs141302038	R393W	0.57
UCEC	chr16	58718605	Silent	rs541543249	G173G	0.35
UCEC	chr16	58719200	Missense_Mutation	novel	F144Y	0.26
UCEC	chr16	58718587	Silent	novel	Y179Y	0.41
UCEC	chr16	58716690	Missense_Mutation	novel	S276P	0.18
UCEC	chr16	58707892	3'UTR	novel		0.35
UCEC	chr16	58708076	3'UTR	novel		0.4
UCEC	chr16	58722254	Missense_Mutation	NA	N91D	0.2
UCEC	chr16	58707875	3'UTR	novel		0.25
UCEC	chr16	58716025	Silent	novel	L336L	0.13
UCEC	chr16	58716662	Splice_Site	novel	X285_splice	0.19
UCEC	chr16	58716804	Missense_Mutation	novel	L238I	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1525	0.017271
CHOL	DEL	0.1944	0.23475
SKCM	DEL	0.2616	0.036923
TGCT	AMP	0.1067	0.035574
UCEC	DEL	0.2709	4.7164e-05

Survival Analysis

Cancer	P-value	Q-value
SARC	0.048	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.0046	Kaplan-Meier Survival Analysis
HNSC	0.00047	Kaplan-Meier Survival Analysis
SKCM	0.00062	Kaplan-Meier Survival Analysis
BRCA	0.024	Kaplan-Meier Survival Analysis
ESCA	0.025	Kaplan-Meier Survival Analysis
KIRP	0.00054	Kaplan-Meier Survival Analysis
COAD	0.025	Kaplan-Meier Survival Analysis
LAML	0.0061	Kaplan-Meier Survival Analysis
UCEC	0.012	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0054	Kaplan-Meier Survival Analysis
CHOL	0.014	Kaplan-Meier Survival Analysis
LUAD	0.024	Kaplan-Meier Survival Analysis
OV	0.026	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000125166 (Gene tree)
Gene ID: 2806
Gene Symbol: GOT2
Alias: mitAAT|KATIV|KAT4|KYAT4
Full Name: glutamic-oxaloacetic transaminase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 27,227 bases
Position: chr16:58,707,131-58,734,357
Accession: 4433
RBP type: non-canonical RBP
Summary: Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29458450	Transcriptomic and metabolomic responses induced in the livers of growing pigs by a short-term intravenous infusion of sodium butyrate.	Animal	2018 Nov	Ren E	doi: 10.1017/S1751731118000174

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494627	GOT2-204	889	-	-	- (aa)	-	-
ENST00000496461	GOT2-205	981	-	-	- (aa)	-	-
ENST00000492378	GOT2-203	987	-	-	- (aa)	-	-
ENST00000564400	GOT2-206	983	-	-	- (aa)	-	-
ENST00000434819	GOT2-202	1615	-	ENSP00000394100	387 (aa)	-	P00505
ENST00000245206	GOT2-201	2462	-	ENSP00000245206	430 (aa)	-	P00505
ENST00000568368	GOT2-207	516	-	ENSP00000456205	59 (aa)	-	H3BRE7

Gene Model

Click here to download ENSG00000125166's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00220	Arginine biosynthesis	KEGG
hsa00250	Alanine, aspartate and glutamate metabolism	KEGG
hsa00270	Cysteine and methionine metabolism	KEGG
hsa00330	Arginine and proline metabolism	KEGG
hsa00350	Tyrosine metabolism	KEGG
hsa00360	Phenylalanine metabolism	KEGG
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01210	2-Oxocarboxylic acid metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG
hsa04975	Fat digestion and absorption	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000125166	Platelet Function Tests	9.9973322E-006	-
ENSG00000125166	Platelet Function Tests	1.1140300E-005	-
ENSG00000125166	Platelet Function Tests	4.1453646E-006	-
ENSG00000125166	Platelet Function Tests	4.7680432E-006	-
ENSG00000125166	Aorta	3E-6	21223598

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000125166	rs73550818	16	58730951	?	Aspartate aminotransferase levels	29403010	[0.021-0.037] unit increase novel	0.02855	EFO_0004736
ENSG00000125166	rs12600277	16	58725428	?	Aortic root size	21223598	[0.082-0.198] cm increase	0.1399	EFO_0005037

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125166's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000125166	GOT2	93	43.284	WBGene00020146	got-1.2	97	43.577	Caenorhabditis_elegans
ENSG00000125166	GOT2	96	63.107	FBgn0001125	Got2	96	63.107	Drosophila_melanogaster
ENSG00000125166	GOT2	95	48.058	FBgn0001124	Got1	95	48.866	Drosophila_melanogaster
ENSG00000125166	GOT2	93	48.894	ENSG00000120053	GOT1	98	48.889	Homo_sapiens
ENSG00000125166	GOT2	100	94.651	ENSMUSG00000031672	Got2	100	94.651	Mus_musculus
ENSG00000125166	GOT2	93	43.659	YLR027C	AAT2	97	44.089	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	21873635.	IBA	Function
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	2182221.2567216.2731362.	IDA	Function
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	-	ISS	Function
GO:0005543	phospholipid binding	-	IEA	Function
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	9537447.	IDA	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0005743	mitochondrial inner membrane	-	IEA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005886	plasma membrane	9537447.	IDA	Component
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0006103	2-oxoglutarate metabolic process	-	ISS	Process
GO:0006107	oxaloacetate metabolic process	-	IEA	Process
GO:0006531	aspartate metabolic process	-	ISS	Process
GO:0006532	aspartate biosynthetic process	-	IEA	Process
GO:0006533	aspartate catabolic process	21873635.	IBA	Process
GO:0006533	aspartate catabolic process	2567216.	IDA	Process
GO:0006536	glutamate metabolic process	-	ISS	Process
GO:0007565	female pregnancy	-	IEA	Process
GO:0007595	lactation	-	IEA	Process
GO:0008652	cellular amino acid biosynthetic process	-	TAS	Process
GO:0009986	cell surface	-	IEA	Component
GO:0014850	response to muscle activity	-	IEA	Process
GO:0015908	fatty acid transport	9537447.	IEP	Process
GO:0016212	kynurenine-oxoglutarate transaminase activity	-	IEA	Function
GO:0016597	amino acid binding	-	IEA	Function
GO:0019470	4-hydroxyproline catabolic process	21998747.	TAS	Process
GO:0019550	glutamate catabolic process to aspartate	-	IEA	Process
GO:0019551	glutamate catabolic process to 2-oxoglutarate	-	IEA	Process
GO:0019899	enzyme binding	-	IEA	Function
GO:0030170	pyridoxal phosphate binding	-	IEA	Function
GO:0030315	T-tubule	-	IEA	Component
GO:0032868	response to insulin	-	IEA	Process
GO:0032991	protein-containing complex	-	IEA	Component
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0043204	perikaryon	-	IEA	Component
GO:0043278	response to morphine	-	IEA	Process
GO:0045471	response to ethanol	9537447.	IDA	Process
GO:0046487	glyoxylate metabolic process	-	TAS	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0097052	L-kynurenine metabolic process	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.