EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24024181	Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma.	Biomed Res Int	2013	Bagnoli M	doi: 10.1155/2013/143202
25301721	Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia.	Oncotarget	2014 Oct 15	Copsel S	-
23575399	Downregulation of ATP-binding cassette subfamily C member 4 increases sensitivity to neoadjuvant radiotherapy for locally advanced rectal carcinoma.	Dis Colon Rectum	2013 May	Yu ZQ	doi: 10.1097/DCR.0b013e31827c2b80.
25572969	Silencing of the ABCC4 gene by RNA interference reverses multidrug resistance in human gastric cancer.	Oncol Rep	2015 Mar	Zhang G	doi: 10.3892/or.2014.3702
24694755	Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development.	PLoS One	2014 Apr 2	Pereira C	doi: 10.1371/journal.pone.0092000
24510239	ABCC4 copy number variation is associated with susceptibility to esophageal squamous cell carcinoma.	Carcinogenesis	2014 Sep	Sun Y	doi: 10.1093/carcin/bgu043
17003774	Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells.	Prostate Cancer Prostatic Dis	2007	Cai C	-
25433169	Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.	Prostaglandins Other Lipid Mediat	2015 Jan-Mar	Kochel TJ	doi: 10.1016/j.prostaglandins.2014.11.003
24909729	Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway.	Eur J Pharm Sci	2014 Oct 1	Maeng HJ	doi: 10.1016/j.ejps.2014.05.023
28011504	Prognostic and Therapeutic Potential Implications of Genetic Variability in Prostaglandin E2 Pathway Genes in Rectal Cancer.	Anticancer Res	2017 Jan	Santos MD	-
18615486	Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer.	Prostate	2008 Sep 15	Ho LL	doi: 10.1002/pros.20809.
24606721	RNAi-mediated silencing of ATP-binding cassette C4 protein inhibits cell growth in MGC80-3 gastric cancer cell lines.	Cell Mol Biol (Noisy-le-grand)	2014 Mar 5	Chen L	-
18690847	Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.	Curr Cancer Drug Targets	2008 Aug	Gradilone A	-
12792791	Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine.	Int J Oncol	2003 Jul	Savaraj N	-
17878487	Celecoxib induces MRP-4 in lung cancer cells: therapeutic implications.	J Clin Oncol	2007 Sep 20	Gradilone A	-
21866459	[Preliminary study on relationship between multi-drug resistance-associated protein 4 and radiosensitivity of rectal cancer].	Zhonghua Wei Chang Wai Ke Za Zhi	2011 Aug	Chai R	-
26600514	Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.	Genet Mol Res	2015 Nov 19	Chen SF	doi: 10.4238/2015.November.18.18.
28029661	Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.	Oncotarget	2017 Jan 24	Kochel TJ	doi: 10.18632/oncotarget.14145.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr13	95177757	Silent	rs760295308	D559D	0.29
ACC	chr13	95188492	Silent	rs150945397	G438G	0.89
BLCA	chr13	95206561	Missense_Mutation	novel	E378Q	0.32
BLCA	chr13	95044301	Missense_Mutation	novel	L1198F	0.36
BLCA	chr13	95074325	Splice_Site	NA	X936_splice	0.33
BLCA	chr13	95075480	Missense_Mutation	novel	E920K	0.32
BLCA	chr13	95188536	Missense_Mutation	NA	E424K	0.33
BLCA	chr13	95177728	Missense_Mutation	novel	V569D	0.52
BLCA	chr13	95044304	Missense_Mutation	novel	I1197M	0.48
BLCA	chr13	95161318	Missense_Mutation	rs146708960	V776I	0.2
BLCA	chr13	95083246	Silent	rs762094616	V860V	0.38
BLCA	chr13	95247091	Missense_Mutation	novel	W64R	0.09
BLCA	chr13	95247730	Missense_Mutation	novel	I33S	0.12
BLCA	chr13	95062790	Missense_Mutation	novel	P1094A	0.25
BLCA	chr13	95209436	Splice_Region	novel	L261L	0.08
BLCA	chr13	95164458	Nonsense_Mutation	novel	Q699*	0.27
BRCA	chr13	95075506	Missense_Mutation	NA	L911P	0.23
BRCA	chr13	95177769	Silent	NA	I555I	0.35
BRCA	chr13	95044326	Missense_Mutation	NA	A1190E	0.12
BRCA	chr13	95044276	Missense_Mutation	NA	V1207M	0.49
BRCA	chr13	95166296	Nonsense_Mutation	novel	*K632delinsNLMQEL**	0.07
BRCA	chr13	95177792	Missense_Mutation	novel	A548T	0.04
BRCA	chr13	95194900	Missense_Mutation	rs761410807	R400H	0.16
BRCA	chr13	95062756	Missense_Mutation	NA	T1105K	0.11
BRCA	chr13	95071728	Missense_Mutation	novel	F1048L	0.09
BRCA	chr13	95209553	Silent	NA	A222A	0.47
BRCA	chr13	95044402	Missense_Mutation	NA	K1165E	0.19
BRCA	chr13	95021166	3'UTR	novel		0.25
BRCA	chr13	95209512	Missense_Mutation	NA	S236L	0.3
BRCA	chr13	95062706	Missense_Mutation	novel	Q1122E	0.14
BRCA	chr13	95115987	Missense_Mutation	rs199702034	R824C	0.09
BRCA	chr13	95247691	Missense_Mutation	rs775555726	S46L	0.41
CESC	chr13	95206608	Missense_Mutation	novel	R362Q	0.25
CESC	chr13	95246994	Missense_Mutation	NA	G96E	0.27
CESC	chr13	95206564	Missense_Mutation	novel	S377P	0.38
CESC	chr13	95246984	Silent	novel	T99T	0.33
CESC	chr13	95020338	3'UTR	novel		0.54
CESC	chr13	95062756	Missense_Mutation	novel	T1105I	0.4
CESC	chr13	95075549	Missense_Mutation	rs769663620	R897W	0.14
CESC	chr13	95044417	Nonsense_Mutation	NA	E1160*	0.18
CESC	chr13	95186825	Missense_Mutation	NA	R474T	0.15
CESC	chr13	95247744	Splice_Site	novel	X25_splice	0.32
CHOL	chr13	95206669	Missense_Mutation	novel	L342I	0.12
COAD	chr13	95021605	Silent	rs550257734	S1316S	0.37
COAD	chr13	95234639	Missense_Mutation	NA	V168I	0.32
COAD	chr13	95166203	Silent	rs775937284	Q663Q	0.38
COAD	chr13	95234619	Silent	novel	I174I	0.15
COAD	chr13	95021590	Silent	rs768473583	F1321F	0.6
COAD	chr13	95206542	Missense_Mutation	rs763493372	R384Q	0.31
COAD	chr13	95206634	In_Frame_Del	novel	I346_V353del	0.97
COAD	chr13	95178049	Missense_Mutation	novel	D530Y	0.38
COAD	chr13	95209498	Missense_Mutation	novel	M241V	0.27
COAD	chr13	95021674	Silent	novel	F1293F	0.14
COAD	chr13	95021525	3'UTR	novel		0.32
COAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.21
COAD	chr13	95021494	3'UTR	novel		0.22
COAD	chr13	95188467	Missense_Mutation	NA	V447M	0.17
COAD	chr13	95075549	Missense_Mutation	rs769663620	R897W	0.42
COAD	chr13	95247083	Missense_Mutation	NA	K66N	0.15
COAD	chr13	95164395	Silent	NA	L720L	0.15
COAD	chr13	95186743	Missense_Mutation	NA	K501N	0.34
COAD	chr13	95247037	Silent	NA	R82R	0.3
COAD	chr13	95074300	Missense_Mutation	rs750954023	T944M	0.47
COAD	chr13	95044329	Missense_Mutation	NA	R1189M	0.27
COAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.22
COAD	chr13	95021494	3'UTR	novel		0.33
COAD	chr13	95209549	Missense_Mutation	NA	A224T	0.39
COAD	chr13	95161322	Frame_Shift_Ins	novel	*T775Rfs21**	0.09
COAD	chr13	95161324	Missense_Mutation	novel	A774T	0.06
COAD	chr13	95170583	Silent	novel	T591T	0.33
COAD	chr13	95188492	Silent	rs150945397	G438G	0.27
COAD	chr13	95178063	Missense_Mutation	novel	L525P	0.19
ESCA	chr13	95043759	Missense_Mutation	rs200017194	R1220W	0.38
ESCA	chr13	95178013	Missense_Mutation	rs767916913	R542W	0.14
ESCA	chr13	95206581	Nonsense_Mutation	novel	S371*	0.18
GBM	chr13	95210739	Missense_Mutation	novel	G192S	0.09
GBM	chr13	95166219	Missense_Mutation	novel	S658L	0.62
GBM	chr13	95053138	Missense_Mutation	NA	F1138C	0.29
GBM	chr13	95206723	Missense_Mutation	novel	F324I	0.07
GBM	chr13	95053104	Silent	novel	A1149A	0.12
GBM	chr13	95071805	Missense_Mutation	novel	A1023T	0.08
GBM	chr13	95062826	Missense_Mutation	NA	S1082G	0.34
GBM	chr13	95043680	Splice_Site	novel	X1245_splice	0.63
GBM	chr13	95043772	Missense_Mutation	novel	I1215M	0.06
GBM	chr13	95210705	Missense_Mutation	novel	N203I	0.08
GBM	chr13	95021606	Missense_Mutation	NA	S1316L	0.78
HNSC	chr13	95161194	Missense_Mutation	novel	P817L	0.31
HNSC	chr13	95161195	Missense_Mutation	novel	P817S	0.32
HNSC	chr13	95075440	Missense_Mutation	novel	L933S	0.36
HNSC	chr13	95206745	Silent	novel	L316L	0.16
KIRC	chr13	95170599	Missense_Mutation	NA	I586T	0.35
KIRC	chr13	95206752	Missense_Mutation	NA	S314C	0.23
KIRC	chr13	95075503	Missense_Mutation	novel	W912L	0.04
KIRC	chr13	95177749	Missense_Mutation	NA	L562R	0.37
KIRC	chr13	95186717	Missense_Mutation	NA	A510V	0.13
KIRC	chr13	95210707	Silent	NA	V202V	0.16
KIRC	chr13	95074290	Missense_Mutation	novel	W947C	0.17
KIRP	chr13	95234610	Missense_Mutation	NA	K177N	0.49
KIRP	chr13	95234611	Missense_Mutation	NA	K177T	0.48
KIRP	chr13	95188461	Missense_Mutation	NA	A449S	0.21
LGG	chr13	95188492	Silent	rs150945397	G438G	0.37
LGG	chr13	95206542	Missense_Mutation	rs763493372	R384Q	0.26
LGG	chr13	95034628	Missense_Mutation	novel	A1283T	0.09
LGG	chr13	95071831	Missense_Mutation	novel	I1014T	0.28
LGG	chr13	95083155	Missense_Mutation	novel	R891C	0.32
LGG	chr13	95062830	Frame_Shift_Ins	novel	*K1081Sfs13**	0.09
LIHC	chr13	95164379	Missense_Mutation	NA	Q725L	0.24
LIHC	chr13	95206699	Missense_Mutation	rs377022090	V332M	0.35
LIHC	chr13	95206656	Missense_Mutation	novel	I346N	0.39
LIHC	chr13	95234759	Missense_Mutation	NA	S128A	0.24
LIHC	chr13	95115946	Silent	rs148807118	P837P	0.29
LIHC	chr13	95206703	Silent	NA	I330I	0.48
LIHC	chr13	95170571	Missense_Mutation	novel	Q595H	0.43
LUAD	chr13	95166228	Nonsense_Mutation	NA	S655*	0.06
LUAD	chr13	95073254	Missense_Mutation	novel	M990L	0.52
LUAD	chr13	95194901	Missense_Mutation	rs200696756	R400C	0.21
LUAD	chr13	95177719	Missense_Mutation	NA	H572L	0.28
LUAD	chr13	95164456	Missense_Mutation	novel	Q699H	0.24
LUAD	chr13	95247718	Missense_Mutation	rs767254775	R37Q	0.42
LUAD	chr13	95209456	Missense_Mutation	novel	G255W	0.25
LUAD	chr13	95178067	Missense_Mutation	novel	D524Y	0.16
LUAD	chr13	95062704	Missense_Mutation	NA	Q1122H	0.22
LUAD	chr13	95166157	Splice_Site	novel	X678_splice	0.42
LUAD	chr13	95071698	Silent	NA	L1058L	0.07
LUAD	chr13	95083201	Missense_Mutation	novel	F875L	0.3
LUAD	chr13	95206531	Splice_Site	novel	X387_splice	0.31
LUAD	chr13	95206625	Silent	novel	T356T	0.3
LUAD	chr13	95166201	Missense_Mutation	NA	S664C	0.3
LUAD	chr13	95188543	Splice_Site	NA	X422_splice	0.29
LUAD	chr13	95210694	Nonsense_Mutation	NA	Q207*	0.11
LUAD	chr13	95053140	Silent	NA	P1137P	0.15
LUAD	chr13	95188457	Missense_Mutation	NA	G450V	0.16
LUAD	chr13	95166341	Frame_Shift_Del	novel	Y617*	0.14
LUAD	chr13	95071783	Missense_Mutation	NA	R1030L	0.25
LUSC	chr13	95062803	Silent	novel	F1089F	0.42
LUSC	chr13	95163212	Missense_Mutation	novel	N740Y	0.25
LUSC	chr13	95034692	Frame_Shift_Ins	novel	*L1261Ffs59**	0.29
LUSC	chr13	95044365	Missense_Mutation	novel	F1177S	0.43
LUSC	chr13	95071851	Missense_Mutation	novel	M1007I	0.44
LUSC	chr13	95062754	Missense_Mutation	rs776055053	T1106A	0.21
LUSC	chr13	95021642	Missense_Mutation	novel	D1304G	0.42
OV	chr13	95096047	Intron	novel		0.09
OV	chr13	95044389	Missense_Mutation	novel	E1169G	0.13
OV	chr13	95177792	Missense_Mutation	novel	A548S	0.09
PAAD	chr13	95083163	Missense_Mutation	novel	D888V	0.2
PAAD	chr13	95161279	Missense_Mutation	rs779403637	V789I	0.15
PAAD	chr13	95234738	Missense_Mutation	novel	Y135H	0.19
PRAD	chr13	95206543	Nonsense_Mutation	NA	R384*	0.21
PRAD	chr13	95194895	In_Frame_Del	novel	R400_Q401del	0.12
PRAD	chr13	95210737	Silent	NA	G192G	0.17
PRAD	chr13	95247700	Missense_Mutation	NA	D43A	0.35
PRAD	chr13	95210726	Missense_Mutation	rs200675964	N196S	0.11
READ	chr13	95186893	Splice_Site	novel	X452_splice	0.41
READ	chr13	95071665	Silent	novel	E1069E	0.25
READ	chr13	95234735	Missense_Mutation	NA	A136T	0.38
SKCM	chr13	95115928	Silent	novel	F843F	0.06
SKCM	chr13	95161219	Missense_Mutation	NA	P809S	0.61
SKCM	chr13	95164472	Missense_Mutation	novel	G694E	0.53
SKCM	chr13	95062822	Missense_Mutation	NA	S1083F	0.28
SKCM	chr13	95206663	Missense_Mutation	novel	S344G	0.19
SKCM	chr13	95206718	Silent	NA	F325F	0.08
SKCM	chr13	95073278	Missense_Mutation	novel	A982T	0.11
SKCM	chr13	95188453	Splice_Region	novel	K451K	0.45
SKCM	chr13	95206534	Nonsense_Mutation	NA	Q387*	0.5
SKCM	chr13	95083225	Silent	NA	P867P	0.25
SKCM	chr13	95170538	Silent	NA	L606L	0.35
SKCM	chr13	95209577	Silent	NA	F214F	0.29
SKCM	chr13	95206645	Missense_Mutation	rs532299842	R350C	0.26
SKCM	chr13	95177765	Missense_Mutation	NA	L557F	0.54
SKCM	chr13	95209577	Silent	NA	F214F	0.15
SKCM	chr13	95164433	Missense_Mutation	novel	A707V	0.3
SKCM	chr13	95164486	Silent	NA	E689E	0.39
SKCM	chr13	95166305	Silent	novel	S629S	0.63
SKCM	chr13	95062822	Missense_Mutation	NA	S1083F	0.45
SKCM	chr13	95021608	Silent	NA	P1315P	0.23
SKCM	chr13	95194935	Splice_Region	NA	T388T	0.83
SKCM	chr13	95164438	Silent	rs761242748	F705F	0.32
SKCM	chr13	95177785	Missense_Mutation	NA	Y550C	0.32
SKCM	chr13	95161311	Missense_Mutation	NA	F778S	0.3
SKCM	chr13	95206534	Nonsense_Mutation	NA	Q387*	0.4
SKCM	chr13	95177763	Silent	NA	L557L	0.42
SKCM	chr13	95164432	Silent	NA	A707A	0.24
SKCM	chr13	95206706	Missense_Mutation	novel	K329N	0.18
SKCM	chr13	95206586	Silent	rs780319858	F369F	0.08
SKCM	chr13	95209480	Missense_Mutation	NA	L247F	0.13
SKCM	chr13	95206637	Silent	rs764661404	F352F	0.28
SKCM	chr13	95206725	Missense_Mutation	rs375104829	S323L	0.25
SKCM	chr13	95044316	Silent	novel	R1193R	0.26
SKCM	chr13	95177756	Missense_Mutation	novel	D560N	0.43
SKCM	chr13	95021571	3'UTR	novel		0.25
SKCM	chr13	95164405	Silent	NA	F716F	0.19
SKCM	chr13	95073236	Missense_Mutation	NA	C996G	0.3
SKCM	chr13	95075543	Missense_Mutation	rs780945816	P899S	0.45
SKCM	chr13	95074230	Silent	NA	S967S	0.34
SKCM	chr13	95206725	Missense_Mutation	rs375104829	S323L	0.31
SKCM	chr13	95074231	Missense_Mutation	NA	S967F	0.21
SKCM	chr13	95177708	Splice_Region	NA	L576L	0.21
SKCM	chr13	95210780	Missense_Mutation	novel	A178E	0.39
STAD	chr13	95209537	Missense_Mutation	NA	L228I	0.11
STAD	chr13	95074244	Missense_Mutation	rs376326528	V963I	0.19
STAD	chr13	95188491	Missense_Mutation	NA	E439K	0.33
STAD	chr13	95062736	Missense_Mutation	rs771698317	D1112N	0.05
STAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.26
STAD	chr13	95071661	Splice_Site	NA	X1070_splice	0.19
STAD	chr13	95188491	Missense_Mutation	NA	E439K	0.25
STAD	chr13	95034716	Missense_Mutation	NA	K1253N	0.05
STAD	chr13	95043762	Frame_Shift_Del	rs756859429	*I1219Sfs11**	0.43
STAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.41
STAD	chr13	95188464	Nonsense_Mutation	novel	G448*	0.22
STAD	chr13	95021494	3'UTR	novel		0.28
STAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.17
STAD	chr13	95083195	Frame_Shift_Del	novel	*L878Ffs12**	0.16
STAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.37
STAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.23
STAD	chr13	95206750	Missense_Mutation	NA	C315S	0.08
STAD	chr13	95161280	Silent	rs11568709	Y788Y	0.44
STAD	chr13	95207918	Missense_Mutation	NA	T265A	0.48
STAD	chr13	95170591	Silent	novel	L589L	0.27
STAD	chr13	95186835	Missense_Mutation	rs368213763	V471M	0.17
STAD	chr13	95234735	Missense_Mutation	NA	A136T	0.38
STAD	chr13	95301273	Missense_Mutation	novel	Q14H	0.1
STAD	chr13	95186820	Missense_Mutation	novel	A476T	0.13
STAD	chr13	95161279	Missense_Mutation	rs779403637	V789I	0.14
STAD	chr13	95206676	Silent	rs571589752	Y339Y	0.32
STAD	chr13	95247673	Missense_Mutation	rs142182014	R52H	0.45
STAD	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.2
STAD	chr13	95043762	Frame_Shift_Del	rs756859429	*I1219Sfs11**	0.42
TGCT	chr13	95206645	Missense_Mutation	novel	R350S	0.31
THYM	chr13	95043767	Missense_Mutation	novel	K1217R	0.36
UCEC	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.53
UCEC	chr13	95044311	Frame_Shift_Del	novel	*N1195Ifs4**	0.29
UCEC	chr13	95071675	Missense_Mutation	rs151127848	K1066T	0.32
UCEC	chr13	95234795	Missense_Mutation	NA	I116V	0.36
UCEC	chr13	95021303	3'UTR	novel		0.17
UCEC	chr13	95034666	Missense_Mutation	novel	Y1270C	0.32
UCEC	chr13	95207803	Missense_Mutation	novel	R303K	0.38
UCEC	chr13	95073230	Nonsense_Mutation	rs149024948	R998*	0.19
UCEC	chr13	95074226	Missense_Mutation	novel	I969V	0.08
UCEC	chr13	95043735	Missense_Mutation	rs141672372	V1228M	0.39
UCEC	chr13	95053140	Silent	novel	P1137P	0.3
UCEC	chr13	95075515	Missense_Mutation	rs199652249	L908R	0.2
UCEC	chr13	95186801	Missense_Mutation	novel	P482H	0.22
UCEC	chr13	95021537	3'UTR	novel		0.18
UCEC	chr13	95021154	3'UTR	novel		0.36
UCEC	chr13	95194895	Silent	NA	L402L	0.53
UCEC	chr13	95073293	Missense_Mutation	novel	G977R	0.42
UCEC	chr13	95115946	Silent	rs148807118	P837P	0.36
UCEC	chr13	95071667	Nonsense_Mutation	NA	E1069*	0.45
UCEC	chr13	95044414	Missense_Mutation	novel	D1161Y	0.41
UCEC	chr13	95188491	Missense_Mutation	NA	E439K	0.39
UCEC	chr13	95234797	Missense_Mutation	novel	K115T	0.37
UCEC	chr13	95021214	3'UTR	novel		0.31
UCEC	chr13	95210775	Missense_Mutation	rs267603866	R180C	0.2
UCEC	chr13	95083187	Missense_Mutation	rs201390689	R880Q	0.38
UCEC	chr13	95247012	Missense_Mutation	NA	K90T	0.38
UCEC	chr13	95115998	Missense_Mutation	rs11568659	R820I	0.26
UCEC	chr13	95247008	Silent	NA	S91S	0.18
UCEC	chr13	95034740	Splice_Site	NA	X1246_splice	0.27
UCEC	chr13	95044287	Missense_Mutation	rs373949612	A1203V	0.17
UCEC	chr13	95071820	Missense_Mutation	NA	D1018Y	0.44
UCEC	chr13	95074283	Missense_Mutation	rs753708057	V950I	0.45
UCEC	chr13	95177736	Silent	rs774233830	D566D	0.3
UCEC	chr13	95178015	Missense_Mutation	novel	A541V	0.08
UCEC	chr13	95188467	Missense_Mutation	NA	V447M	0.15
UCEC	chr13	95301291	Silent	novel	V8V	0.45
UCEC	chr13	95209587	Missense_Mutation	novel	F211S	0.09
UCEC	chr13	95073229	Missense_Mutation	rs767394657	R998Q	0.38
UCEC	chr13	95164478	Missense_Mutation	novel	S692Y	0.1
UCEC	chr13	95021421	3'UTR	novel		0.15
UCEC	chr13	95071848	Silent	novel	I1008I	0.09
UCEC	chr13	95115933	Missense_Mutation	novel	D842Y	0.45
UCEC	chr13	95186748	Missense_Mutation	rs145886106	E500K	0.24
UCEC	chr13	95021487	3'UTR	novel		0.29
UCEC	chr13	95043788	Splice_Site	novel	X1210_splice	0.25
UCEC	chr13	95044426	Missense_Mutation	novel	E1157K	0.18
UCEC	chr13	95166344	Silent	novel	T616T	0.19
UCEC	chr13	95206588	Missense_Mutation	novel	F369V	0.18
UCEC	chr13	95234740	Missense_Mutation	novel	A134V	0.22
UCEC	chr13	95021448	3'UTR	novel		0.29
UCEC	chr13	95246978	Silent	novel	I101I	0.26
UCEC	chr13	95071833	Silent	novel	V1013V	0.45
UCEC	chr13	95166363	Missense_Mutation	novel	K610T	0.47
UCEC	chr13	95021542	3'UTR	novel		0.39
UCEC	chr13	95043683	Missense_Mutation	novel	M1245T	0.37
UCEC	chr13	95053160	Missense_Mutation	novel	M1131L	0.2
UCEC	chr13	95166237	Missense_Mutation	novel	R652H	0.3
UCEC	chr13	95234709	Silent	novel	C144C	0.29
UCEC	chr13	95247751	Missense_Mutation	novel	W26L	0.38
UCEC	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.17
UCEC	chr13	95020767	3'UTR	novel		0.33
UCEC	chr13	95021089	3'UTR	novel		0.37
UCEC	chr13	95073229	Missense_Mutation	rs767394657	R998Q	0.58
UCEC	chr13	95075462	Missense_Mutation	novel	L926M	0.13
UCEC	chr13	95166316	Missense_Mutation	novel	D626Y	0.46
UCEC	chr13	95206700	Silent	rs550657413	I331I	0.56
UCEC	chr13	95166296	Nonsense_Mutation	novel	*K632delinsNLMQEL**	0.08
UCEC	chr13	95021563	3'UTR	novel		0.53
UCEC	chr13	95207879	Nonsense_Mutation	NA	E278*	0.39
UCEC	chr13	95020367	3'UTR	novel		0.25
UCEC	chr13	95021377	3'UTR	novel		0.5
UCEC	chr13	95021664	Missense_Mutation	novel	Y1297D	0.24
UCEC	chr13	95163178	Missense_Mutation	novel	G751E	0.31
UCEC	chr13	95163131	Missense_Mutation	novel	I767L	0.2
UCEC	chr13	95053159	Missense_Mutation	NA	M1131T	0.36
UCEC	chr13	95021252	3'UTR	novel		0.36
UCEC	chr13	95075478	Missense_Mutation	rs776637323	E920D	0.09
UCEC	chr13	95178035	Silent	novel	T534T	0.35
UCEC	chr13	95186737	Silent	novel	R503R	0.4
UCEC	chr13	95234639	Missense_Mutation	NA	V168I	0.33
UCEC	chr13	95062736	Missense_Mutation	rs771698317	D1112N	0.18
UCEC	chr13	95075553	Splice_Site	novel	X896_splice	0.17
UCEC	chr13	95115966	Missense_Mutation	NA	H831Y	0.3
UCEC	chr13	95021289	3'UTR	novel		0.47
UCEC	chr13	95021611	Silent	novel	Q1314Q	0.16
UCEC	chr13	95083178	Frame_Shift_Del	NA	*L883Wfs7**	0.3
UCEC	chr13	95062827	Missense_Mutation	NA	K1081N	0.42
UCEC	chr13	95071667	Nonsense_Mutation	NA	E1069*	0.42
UCEC	chr13	95194938	Splice_Site	NA	X388_splice	0.47
UCEC	chr13	95043762	Frame_Shift_Del	rs756859429	*I1219Sfs11**	0.39
UCEC	chr13	95021605	Silent	rs550257734	S1316S	0.32
UCEC	chr13	95178074	Missense_Mutation	NA	E521D	0.15
UCEC	chr13	95075466	Missense_Mutation	novel	Q924H	0.41
UCEC	chr13	95164447	Missense_Mutation	novel	K702N	0.35
UCEC	chr13	95188534	Missense_Mutation	novel	E424D	0.38
UCEC	chr13	95083165	Missense_Mutation	novel	R887S	0.45
UCEC	chr13	95166321	Missense_Mutation	NA	G624D	0.07
UCEC	chr13	95188467	Missense_Mutation	NA	V447M	0.51
UCEC	chr13	95206741	Missense_Mutation	NA	G318R	0.24
UCEC	chr13	95020548	3'UTR	novel		0.18
UCEC	chr13	95034640	Missense_Mutation	NA	A1279T	0.42
UCEC	chr13	95071832	Missense_Mutation	novel	I1014V	0.41
UCEC	chr13	95234666	Missense_Mutation	rs745785051	V159I	0.38
UCS	chr13	95194906	Missense_Mutation	rs749961375	R398H	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	AMP	0.1204	0.012126
CESC	AMP	0.1763	0.00028304
LIHC	AMP	0.1297	2.2054e-10
LUAD	AMP	0.1027	0.027609
UCS	AMP	0.4107	0.0028198

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.00026	Kaplan-Meier Survival Analysis
ACC	0.046	Kaplan-Meier Survival Analysis
PRAD	0.046	Kaplan-Meier Survival Analysis
KIRP	0.0045	Kaplan-Meier Survival Analysis
BLCA	0.014	Kaplan-Meier Survival Analysis
CESC	0.02	Kaplan-Meier Survival Analysis
UCEC	0.0032	Kaplan-Meier Survival Analysis
GBM	0.032	Kaplan-Meier Survival Analysis
LIHC	0.0093	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis
UVM	0.00018	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000125257 (Gene tree)
Gene ID: 10257
Gene Symbol: ABCC4
Alias: MRP4|EST170205|MOAT-B|MOATB
Full Name: ATP binding cassette subfamily C member 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 281,647 bases
Position: chr13:95,019,829-95,301,475
Accession: 55
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22840641	The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans.	Vet Parasitol	2012 Dec 21	Yan R	doi: 10.1016/j.vetpar.2012.06.038

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000642524	ABCC4-208	2256	-	ENSP00000493766	52 (aa)	-	A0A2R8YDG7
ENST00000643816	ABCC4-211	3480	-	-	- (aa)	-	-
ENST00000643051	ABCC4-209	6171	-	ENSP00000495513	800 (aa)	-	A0A2R8Y6V8
ENST00000643556	ABCC4-210	3059	-	ENSP00000494938	35 (aa)	-	A0A2R8Y5Z3
ENST00000484109	ABCC4-205	532	-	-	- (aa)	-	-
ENST00000643842	ABCC4-212	5999	-	ENSP00000493861	39 (aa)	-	Q8IWU1
ENST00000536256	ABCC4-206	2840	-	ENSP00000442024	784 (aa)	-	O15439
ENST00000645532	ABCC4-216	2103	-	ENSP00000494431	669 (aa)	-	A0A2R8YDC1
ENST00000474158	ABCC4-204	448	-	-	- (aa)	-	-
ENST00000467685	ABCC4-202	357	-	-	- (aa)	-	-
ENST00000471041	ABCC4-203	747	-	-	- (aa)	-	-
ENST00000629385	ABCC4-207	2903	XM_017020320	ENSP00000487081	859 (aa)	XP_016875809	O15439
ENST00000376887	ABCC4-201	5841	XM_005254025	ENSP00000366084	1325 (aa)	XP_005254082	O15439
ENST00000644880	ABCC4-214	562	-	-	- (aa)	-	-
ENST00000646439	ABCC4-217	3863	-	ENSP00000494751	1278 (aa)	-	O15439
ENST00000644471	ABCC4-213	2225	-	-	- (aa)	-	-
ENST00000645237	ABCC4-215	5856	-	ENSP00000494609	1325 (aa)	-	O15439

Gene Model

Click here to download ENSG00000125257's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01523	Antifolate resistance	KEGG
hsa02010	ABC transporters	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04976	Bile secretion	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000125257	Body Mass Index	6.83377798271767E-5	17903300
ENSG00000125257	Lipoproteins, VLDL	3.16179372242532E-6	17903299
ENSG00000125257	Lipoproteins, VLDL	2.14679795383107E-8	17903299
ENSG00000125257	Diabetic Nephropathies	2.4000000E-005	16775037
ENSG00000125257	Diabetic Nephropathies	4.4000000E-005	16775037
ENSG00000125257	Diabetic Nephropathies	2.1000000E-005	16775037
ENSG00000125257	Alcoholism	7.3249e-005	22978509
ENSG00000125257	Alcoholism	4.21319e-005	22978509
ENSG00000125257	Respiratory Function Tests	3.0480000E-005	-
ENSG00000125257	Respiratory Function Tests	1.7910000E-005	-
ENSG00000125257	Erythrocyte Count	4.8930000E-005	-
ENSG00000125257	Ankle Brachial Index	8.6181300E-005	-
ENSG00000125257	Body Mass Index	8.3675311E-005	-
ENSG00000125257	Platelet Function Tests	2.4445400E-005	-
ENSG00000125257	Platelet Function Tests	2.6300000E-006	-
ENSG00000125257	Platelet Function Tests	2.5643400E-005	-
ENSG00000125257	Platelet Function Tests	2.9003900E-005	-
ENSG00000125257	Platelet Function Tests	2.7560900E-005	-
ENSG00000125257	Platelet Function Tests	2.7560900E-005	-
ENSG00000125257	Platelet Function Tests	1.3301100E-005	-
ENSG00000125257	Platelet Function Tests	8.2300000E-006	-
ENSG00000125257	Platelet Function Tests	2.7560900E-005	-
ENSG00000125257	Platelet Function Tests	1.8750100E-005	-
ENSG00000125257	Child Development Disorders, Pervasive	3.1238000E-005	-
ENSG00000125257	Arterial Pressure	1.8030000E-006	-
ENSG00000125257	irinotecan	2E-7	23478653
ENSG00000125257	Carcinoma, Non-Small-Cell Lung	2E-7	23478653
ENSG00000125257	Breast Neoplasms	2E-6	17903305
ENSG00000125257	Bronchial Provocation Tests	7E-6	25514360
ENSG00000125257	Pulmonary Disease, Chronic Obstructive	7E-6	25514360
ENSG00000125257	Platelet Count	7E-12	22139419
ENSG00000125257	Longevity	1E-6	20834067
ENSG00000125257	Metabolism	1E-19	24816252
ENSG00000125257	Metabolism	8E-23	24816252

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000125257	rs16950650	13	95123178	T	Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer	23478653	[8.4-109.0]	30.2	EFO_0004829\|EFO_0003060
ENSG00000125257	rs3765535	13	95163281	G	Airway responsiveness in chronic obstructive pulmonary disease	25514360	[NR] unit increase	0.065	EFO_0006897\|EFO_0000341
ENSG00000125257	rs4148441	13	95245953	G	Platelet count	22139419	[2.94-5.29] 10^9/l increase	4.117	EFO_0004309
ENSG00000125257	rs8002180	13	95270511	T	Blood metabolite levels	24816252	[0.02-0.028] unit decrease	0.024	EFO_0005664
ENSG00000125257	rs4148435	13	95247462	?	Platelet count	29403010	[0.05-0.068] unit increase novel	0.05872	EFO_0004309
ENSG00000125257	rs9524862	13	95242373	A	Platelet count	27863252	[0.028-0.042] unit increase	0.03508941	EFO_0004309
ENSG00000125257	rs4148435	13	95247462	A	Platelet count	27863252	[0.062-0.088] unit increase	0.07469402	EFO_0004309
ENSG00000125257	rs9516547	13	95242683	T	Plateletcrit	27863252	[0.063-0.09] unit increase	0.07672933	EFO_0007985
ENSG00000125257	rs4773860	13	95248987	T	Plateletcrit	27863252	[0.035-0.05] unit increase	0.04226349	EFO_0007985
ENSG00000125257	rs1926657	13	95222702	?	Breast cancer	17903305			EFO_0000305
ENSG00000125257	rs4148546	13	95028031	?	Longevity	20834067			EFO_0004300

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125257's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0005515	protein binding	29146910.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	15297306.25173977.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0010243	response to organonitrogen compound	-	IEA	Process
GO:0014070	response to organic cyclic compound	-	IEA	Process
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	-	TAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	21873635.	IBA	Component
GO:0016020	membrane	15297306.	IDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016323	basolateral plasma membrane	24130369.	IDA	Component
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	7557451.	NAS	Function
GO:0031088	platelet dense granule membrane	15297306.	IDA	Component
GO:0031088	platelet dense granule membrane	-	TAS	Component
GO:0032310	prostaglandin secretion	25173977.	IDA	Process
GO:0042493	response to drug	-	IEA	Process
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	21873635.	IBA	Function
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	Process
GO:0055085	transmembrane transport	21873635.	IBA	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0060271	cilium assembly	25173977.	IMP	Process
GO:0099131	ATP hydrolysis coupled ion transmembrane transport	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.