EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24024181Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma.Biomed Res Int2013Bagnoli Mdoi: 10.1155/2013/143202
25301721Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia.Oncotarget2014 Oct 15Copsel S-
23575399Downregulation of ATP-binding cassette subfamily C member 4 increases sensitivity to neoadjuvant radiotherapy for locally advanced rectal carcinoma.Dis Colon Rectum2013 MayYu ZQdoi: 10.1097/DCR.0b013e31827c2b80.
25572969Silencing of the ABCC4 gene by RNA interference reverses multidrug resistance in human gastric cancer.Oncol Rep2015 MarZhang Gdoi: 10.3892/or.2014.3702
24694755Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development.PLoS One2014 Apr 2Pereira Cdoi: 10.1371/journal.pone.0092000
24510239ABCC4 copy number variation is associated with susceptibility to esophageal squamous cell carcinoma.Carcinogenesis2014 SepSun Ydoi: 10.1093/carcin/bgu043
17003774Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells.Prostate Cancer Prostatic Dis2007Cai C-
25433169Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.Prostaglandins Other Lipid Mediat2015 Jan-MarKochel TJdoi: 10.1016/j.prostaglandins.2014.11.003
24909729Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway.Eur J Pharm Sci2014 Oct 1Maeng HJdoi: 10.1016/j.ejps.2014.05.023
28011504Prognostic and Therapeutic Potential Implications of Genetic Variability in Prostaglandin E2 Pathway Genes in Rectal Cancer.Anticancer Res2017 JanSantos MD-
18615486Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer.Prostate2008 Sep 15Ho LLdoi: 10.1002/pros.20809.
24606721RNAi-mediated silencing of ATP-binding cassette C4 protein inhibits cell growth in MGC80-3 gastric cancer cell lines.Cell Mol Biol (Noisy-le-grand)2014 Mar 5Chen L-
18690847Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.Curr Cancer Drug Targets2008 AugGradilone A-
12792791Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine.Int J Oncol2003 JulSavaraj N-
17878487Celecoxib induces MRP-4 in lung cancer cells: therapeutic implications.J Clin Oncol2007 Sep 20Gradilone A-
21866459[Preliminary study on relationship between multi-drug resistance-associated protein 4 and radiosensitivity of rectal cancer].Zhonghua Wei Chang Wai Ke Za Zhi2011 AugChai R-
26600514Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.Genet Mol Res2015 Nov 19Chen SFdoi: 10.4238/2015.November.18.18.
28029661Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.Oncotarget2017 Jan 24Kochel TJdoi: 10.18632/oncotarget.14145.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1395177757Silentrs760295308D559D0.29
ACCchr1395188492Silentrs150945397G438G0.89
BLCAchr1395206561Missense_MutationnovelE378Q0.32
BLCAchr1395044301Missense_MutationnovelL1198F0.36
BLCAchr1395074325Splice_SiteNAX936_splice0.33
BLCAchr1395075480Missense_MutationnovelE920K0.32
BLCAchr1395188536Missense_MutationNAE424K0.33
BLCAchr1395177728Missense_MutationnovelV569D0.52
BLCAchr1395044304Missense_MutationnovelI1197M0.48
BLCAchr1395161318Missense_Mutationrs146708960V776I0.2
BLCAchr1395083246Silentrs762094616V860V0.38
BLCAchr1395247091Missense_MutationnovelW64R0.09
BLCAchr1395247730Missense_MutationnovelI33S0.12
BLCAchr1395062790Missense_MutationnovelP1094A0.25
BLCAchr1395209436Splice_RegionnovelL261L0.08
BLCAchr1395164458Nonsense_MutationnovelQ699*0.27
BRCAchr1395075506Missense_MutationNAL911P0.23
BRCAchr1395177769SilentNAI555I0.35
BRCAchr1395044326Missense_MutationNAA1190E0.12
BRCAchr1395044276Missense_MutationNAV1207M0.49
BRCAchr1395166296Nonsense_MutationnovelK632delinsNLMQ*EL0.07
BRCAchr1395177792Missense_MutationnovelA548T0.04
BRCAchr1395194900Missense_Mutationrs761410807R400H0.16
BRCAchr1395062756Missense_MutationNAT1105K0.11
BRCAchr1395071728Missense_MutationnovelF1048L0.09
BRCAchr1395209553SilentNAA222A0.47
BRCAchr1395044402Missense_MutationNAK1165E0.19
BRCAchr13950211663'UTRnovel0.25
BRCAchr1395209512Missense_MutationNAS236L0.3
BRCAchr1395062706Missense_MutationnovelQ1122E0.14
BRCAchr1395115987Missense_Mutationrs199702034R824C0.09
BRCAchr1395247691Missense_Mutationrs775555726S46L0.41
CESCchr1395206608Missense_MutationnovelR362Q0.25
CESCchr1395246994Missense_MutationNAG96E0.27
CESCchr1395206564Missense_MutationnovelS377P0.38
CESCchr1395246984SilentnovelT99T0.33
CESCchr13950203383'UTRnovel0.54
CESCchr1395062756Missense_MutationnovelT1105I0.4
CESCchr1395075549Missense_Mutationrs769663620R897W0.14
CESCchr1395044417Nonsense_MutationNAE1160*0.18
CESCchr1395186825Missense_MutationNAR474T0.15
CESCchr1395247744Splice_SitenovelX25_splice0.32
CHOLchr1395206669Missense_MutationnovelL342I0.12
COADchr1395021605Silentrs550257734S1316S0.37
COADchr1395234639Missense_MutationNAV168I0.32
COADchr1395166203Silentrs775937284Q663Q0.38
COADchr1395234619SilentnovelI174I0.15
COADchr1395021590Silentrs768473583F1321F0.6
COADchr1395206542Missense_Mutationrs763493372R384Q0.31
COADchr1395206634In_Frame_DelnovelI346_V353del0.97
COADchr1395178049Missense_MutationnovelD530Y0.38
COADchr1395209498Missense_MutationnovelM241V0.27
COADchr1395021674SilentnovelF1293F0.14
COADchr13950215253'UTRnovel0.32
COADchr1395083178Frame_Shift_DelNAL883Wfs*70.21
COADchr13950214943'UTRnovel0.22
COADchr1395188467Missense_MutationNAV447M0.17
COADchr1395075549Missense_Mutationrs769663620R897W0.42
COADchr1395247083Missense_MutationNAK66N0.15
COADchr1395164395SilentNAL720L0.15
COADchr1395186743Missense_MutationNAK501N0.34
COADchr1395247037SilentNAR82R0.3
COADchr1395074300Missense_Mutationrs750954023T944M0.47
COADchr1395044329Missense_MutationNAR1189M0.27
COADchr1395083178Frame_Shift_DelNAL883Wfs*70.22
COADchr13950214943'UTRnovel0.33
COADchr1395209549Missense_MutationNAA224T0.39
COADchr1395161322Frame_Shift_InsnovelT775Rfs*210.09
COADchr1395161324Missense_MutationnovelA774T0.06
COADchr1395170583SilentnovelT591T0.33
COADchr1395188492Silentrs150945397G438G0.27
COADchr1395178063Missense_MutationnovelL525P0.19
ESCAchr1395043759Missense_Mutationrs200017194R1220W0.38
ESCAchr1395178013Missense_Mutationrs767916913R542W0.14
ESCAchr1395206581Nonsense_MutationnovelS371*0.18
GBMchr1395210739Missense_MutationnovelG192S0.09
GBMchr1395166219Missense_MutationnovelS658L0.62
GBMchr1395053138Missense_MutationNAF1138C0.29
GBMchr1395206723Missense_MutationnovelF324I0.07
GBMchr1395053104SilentnovelA1149A0.12
GBMchr1395071805Missense_MutationnovelA1023T0.08
GBMchr1395062826Missense_MutationNAS1082G0.34
GBMchr1395043680Splice_SitenovelX1245_splice0.63
GBMchr1395043772Missense_MutationnovelI1215M0.06
GBMchr1395210705Missense_MutationnovelN203I0.08
GBMchr1395021606Missense_MutationNAS1316L0.78
HNSCchr1395161194Missense_MutationnovelP817L0.31
HNSCchr1395161195Missense_MutationnovelP817S0.32
HNSCchr1395075440Missense_MutationnovelL933S0.36
HNSCchr1395206745SilentnovelL316L0.16
KIRCchr1395170599Missense_MutationNAI586T0.35
KIRCchr1395206752Missense_MutationNAS314C0.23
KIRCchr1395075503Missense_MutationnovelW912L0.04
KIRCchr1395177749Missense_MutationNAL562R0.37
KIRCchr1395186717Missense_MutationNAA510V0.13
KIRCchr1395210707SilentNAV202V0.16
KIRCchr1395074290Missense_MutationnovelW947C0.17
KIRPchr1395234610Missense_MutationNAK177N0.49
KIRPchr1395234611Missense_MutationNAK177T0.48
KIRPchr1395188461Missense_MutationNAA449S0.21
LGGchr1395188492Silentrs150945397G438G0.37
LGGchr1395206542Missense_Mutationrs763493372R384Q0.26
LGGchr1395034628Missense_MutationnovelA1283T0.09
LGGchr1395071831Missense_MutationnovelI1014T0.28
LGGchr1395083155Missense_MutationnovelR891C0.32
LGGchr1395062830Frame_Shift_InsnovelK1081Sfs*130.09
LIHCchr1395164379Missense_MutationNAQ725L0.24
LIHCchr1395206699Missense_Mutationrs377022090V332M0.35
LIHCchr1395206656Missense_MutationnovelI346N0.39
LIHCchr1395234759Missense_MutationNAS128A0.24
LIHCchr1395115946Silentrs148807118P837P0.29
LIHCchr1395206703SilentNAI330I0.48
LIHCchr1395170571Missense_MutationnovelQ595H0.43
LUADchr1395166228Nonsense_MutationNAS655*0.06
LUADchr1395073254Missense_MutationnovelM990L0.52
LUADchr1395194901Missense_Mutationrs200696756R400C0.21
LUADchr1395177719Missense_MutationNAH572L0.28
LUADchr1395164456Missense_MutationnovelQ699H0.24
LUADchr1395247718Missense_Mutationrs767254775R37Q0.42
LUADchr1395209456Missense_MutationnovelG255W0.25
LUADchr1395178067Missense_MutationnovelD524Y0.16
LUADchr1395062704Missense_MutationNAQ1122H0.22
LUADchr1395166157Splice_SitenovelX678_splice0.42
LUADchr1395071698SilentNAL1058L0.07
LUADchr1395083201Missense_MutationnovelF875L0.3
LUADchr1395206531Splice_SitenovelX387_splice0.31
LUADchr1395206625SilentnovelT356T0.3
LUADchr1395166201Missense_MutationNAS664C0.3
LUADchr1395188543Splice_SiteNAX422_splice0.29
LUADchr1395210694Nonsense_MutationNAQ207*0.11
LUADchr1395053140SilentNAP1137P0.15
LUADchr1395188457Missense_MutationNAG450V0.16
LUADchr1395166341Frame_Shift_DelnovelY617*0.14
LUADchr1395071783Missense_MutationNAR1030L0.25
LUSCchr1395062803SilentnovelF1089F0.42
LUSCchr1395163212Missense_MutationnovelN740Y0.25
LUSCchr1395034692Frame_Shift_InsnovelL1261Ffs*590.29
LUSCchr1395044365Missense_MutationnovelF1177S0.43
LUSCchr1395071851Missense_MutationnovelM1007I0.44
LUSCchr1395062754Missense_Mutationrs776055053T1106A0.21
LUSCchr1395021642Missense_MutationnovelD1304G0.42
OVchr1395096047Intronnovel0.09
OVchr1395044389Missense_MutationnovelE1169G0.13
OVchr1395177792Missense_MutationnovelA548S0.09
PAADchr1395083163Missense_MutationnovelD888V0.2
PAADchr1395161279Missense_Mutationrs779403637V789I0.15
PAADchr1395234738Missense_MutationnovelY135H0.19
PRADchr1395206543Nonsense_MutationNAR384*0.21
PRADchr1395194895In_Frame_DelnovelR400_Q401del0.12
PRADchr1395210737SilentNAG192G0.17
PRADchr1395247700Missense_MutationNAD43A0.35
PRADchr1395210726Missense_Mutationrs200675964N196S0.11
READchr1395186893Splice_SitenovelX452_splice0.41
READchr1395071665SilentnovelE1069E0.25
READchr1395234735Missense_MutationNAA136T0.38
SKCMchr1395115928SilentnovelF843F0.06
SKCMchr1395161219Missense_MutationNAP809S0.61
SKCMchr1395164472Missense_MutationnovelG694E0.53
SKCMchr1395062822Missense_MutationNAS1083F0.28
SKCMchr1395206663Missense_MutationnovelS344G0.19
SKCMchr1395206718SilentNAF325F0.08
SKCMchr1395073278Missense_MutationnovelA982T0.11
SKCMchr1395188453Splice_RegionnovelK451K0.45
SKCMchr1395206534Nonsense_MutationNAQ387*0.5
SKCMchr1395083225SilentNAP867P0.25
SKCMchr1395170538SilentNAL606L0.35
SKCMchr1395209577SilentNAF214F0.29
SKCMchr1395206645Missense_Mutationrs532299842R350C0.26
SKCMchr1395177765Missense_MutationNAL557F0.54
SKCMchr1395209577SilentNAF214F0.15
SKCMchr1395164433Missense_MutationnovelA707V0.3
SKCMchr1395164486SilentNAE689E0.39
SKCMchr1395166305SilentnovelS629S0.63
SKCMchr1395062822Missense_MutationNAS1083F0.45
SKCMchr1395021608SilentNAP1315P0.23
SKCMchr1395194935Splice_RegionNAT388T0.83
SKCMchr1395164438Silentrs761242748F705F0.32
SKCMchr1395177785Missense_MutationNAY550C0.32
SKCMchr1395161311Missense_MutationNAF778S0.3
SKCMchr1395206534Nonsense_MutationNAQ387*0.4
SKCMchr1395177763SilentNAL557L0.42
SKCMchr1395164432SilentNAA707A0.24
SKCMchr1395206706Missense_MutationnovelK329N0.18
SKCMchr1395206586Silentrs780319858F369F0.08
SKCMchr1395209480Missense_MutationNAL247F0.13
SKCMchr1395206637Silentrs764661404F352F0.28
SKCMchr1395206725Missense_Mutationrs375104829S323L0.25
SKCMchr1395044316SilentnovelR1193R0.26
SKCMchr1395177756Missense_MutationnovelD560N0.43
SKCMchr13950215713'UTRnovel0.25
SKCMchr1395164405SilentNAF716F0.19
SKCMchr1395073236Missense_MutationNAC996G0.3
SKCMchr1395075543Missense_Mutationrs780945816P899S0.45
SKCMchr1395074230SilentNAS967S0.34
SKCMchr1395206725Missense_Mutationrs375104829S323L0.31
SKCMchr1395074231Missense_MutationNAS967F0.21
SKCMchr1395177708Splice_RegionNAL576L0.21
SKCMchr1395210780Missense_MutationnovelA178E0.39
STADchr1395209537Missense_MutationNAL228I0.11
STADchr1395074244Missense_Mutationrs376326528V963I0.19
STADchr1395188491Missense_MutationNAE439K0.33
STADchr1395062736Missense_Mutationrs771698317D1112N0.05
STADchr1395083178Frame_Shift_DelNAL883Wfs*70.26
STADchr1395071661Splice_SiteNAX1070_splice0.19
STADchr1395188491Missense_MutationNAE439K0.25
STADchr1395034716Missense_MutationNAK1253N0.05
STADchr1395043762Frame_Shift_Delrs756859429I1219Sfs*110.43
STADchr1395083178Frame_Shift_DelNAL883Wfs*70.41
STADchr1395188464Nonsense_MutationnovelG448*0.22
STADchr13950214943'UTRnovel0.28
STADchr1395083178Frame_Shift_DelNAL883Wfs*70.17
STADchr1395083195Frame_Shift_DelnovelL878Ffs*120.16
STADchr1395083178Frame_Shift_DelNAL883Wfs*70.37
STADchr1395083178Frame_Shift_DelNAL883Wfs*70.23
STADchr1395206750Missense_MutationNAC315S0.08
STADchr1395161280Silentrs11568709Y788Y0.44
STADchr1395207918Missense_MutationNAT265A0.48
STADchr1395170591SilentnovelL589L0.27
STADchr1395186835Missense_Mutationrs368213763V471M0.17
STADchr1395234735Missense_MutationNAA136T0.38
STADchr1395301273Missense_MutationnovelQ14H0.1
STADchr1395186820Missense_MutationnovelA476T0.13
STADchr1395161279Missense_Mutationrs779403637V789I0.14
STADchr1395206676Silentrs571589752Y339Y0.32
STADchr1395247673Missense_Mutationrs142182014R52H0.45
STADchr1395083178Frame_Shift_DelNAL883Wfs*70.2
STADchr1395043762Frame_Shift_Delrs756859429I1219Sfs*110.42
TGCTchr1395206645Missense_MutationnovelR350S0.31
THYMchr1395043767Missense_MutationnovelK1217R0.36
UCECchr1395083178Frame_Shift_DelNAL883Wfs*70.53
UCECchr1395044311Frame_Shift_DelnovelN1195Ifs*40.29
UCECchr1395071675Missense_Mutationrs151127848K1066T0.32
UCECchr1395234795Missense_MutationNAI116V0.36
UCECchr13950213033'UTRnovel0.17
UCECchr1395034666Missense_MutationnovelY1270C0.32
UCECchr1395207803Missense_MutationnovelR303K0.38
UCECchr1395073230Nonsense_Mutationrs149024948R998*0.19
UCECchr1395074226Missense_MutationnovelI969V0.08
UCECchr1395043735Missense_Mutationrs141672372V1228M0.39
UCECchr1395053140SilentnovelP1137P0.3
UCECchr1395075515Missense_Mutationrs199652249L908R0.2
UCECchr1395186801Missense_MutationnovelP482H0.22
UCECchr13950215373'UTRnovel0.18
UCECchr13950211543'UTRnovel0.36
UCECchr1395194895SilentNAL402L0.53
UCECchr1395073293Missense_MutationnovelG977R0.42
UCECchr1395115946Silentrs148807118P837P0.36
UCECchr1395071667Nonsense_MutationNAE1069*0.45
UCECchr1395044414Missense_MutationnovelD1161Y0.41
UCECchr1395188491Missense_MutationNAE439K0.39
UCECchr1395234797Missense_MutationnovelK115T0.37
UCECchr13950212143'UTRnovel0.31
UCECchr1395210775Missense_Mutationrs267603866R180C0.2
UCECchr1395083187Missense_Mutationrs201390689R880Q0.38
UCECchr1395247012Missense_MutationNAK90T0.38
UCECchr1395115998Missense_Mutationrs11568659R820I0.26
UCECchr1395247008SilentNAS91S0.18
UCECchr1395034740Splice_SiteNAX1246_splice0.27
UCECchr1395044287Missense_Mutationrs373949612A1203V0.17
UCECchr1395071820Missense_MutationNAD1018Y0.44
UCECchr1395074283Missense_Mutationrs753708057V950I0.45
UCECchr1395177736Silentrs774233830D566D0.3
UCECchr1395178015Missense_MutationnovelA541V0.08
UCECchr1395188467Missense_MutationNAV447M0.15
UCECchr1395301291SilentnovelV8V0.45
UCECchr1395209587Missense_MutationnovelF211S0.09
UCECchr1395073229Missense_Mutationrs767394657R998Q0.38
UCECchr1395164478Missense_MutationnovelS692Y0.1
UCECchr13950214213'UTRnovel0.15
UCECchr1395071848SilentnovelI1008I0.09
UCECchr1395115933Missense_MutationnovelD842Y0.45
UCECchr1395186748Missense_Mutationrs145886106E500K0.24
UCECchr13950214873'UTRnovel0.29
UCECchr1395043788Splice_SitenovelX1210_splice0.25
UCECchr1395044426Missense_MutationnovelE1157K0.18
UCECchr1395166344SilentnovelT616T0.19
UCECchr1395206588Missense_MutationnovelF369V0.18
UCECchr1395234740Missense_MutationnovelA134V0.22
UCECchr13950214483'UTRnovel0.29
UCECchr1395246978SilentnovelI101I0.26
UCECchr1395071833SilentnovelV1013V0.45
UCECchr1395166363Missense_MutationnovelK610T0.47
UCECchr13950215423'UTRnovel0.39
UCECchr1395043683Missense_MutationnovelM1245T0.37
UCECchr1395053160Missense_MutationnovelM1131L0.2
UCECchr1395166237Missense_MutationnovelR652H0.3
UCECchr1395234709SilentnovelC144C0.29
UCECchr1395247751Missense_MutationnovelW26L0.38
UCECchr1395083178Frame_Shift_DelNAL883Wfs*70.17
UCECchr13950207673'UTRnovel0.33
UCECchr13950210893'UTRnovel0.37
UCECchr1395073229Missense_Mutationrs767394657R998Q0.58
UCECchr1395075462Missense_MutationnovelL926M0.13
UCECchr1395166316Missense_MutationnovelD626Y0.46
UCECchr1395206700Silentrs550657413I331I0.56
UCECchr1395166296Nonsense_MutationnovelK632delinsNLMQ*EL0.08
UCECchr13950215633'UTRnovel0.53
UCECchr1395207879Nonsense_MutationNAE278*0.39
UCECchr13950203673'UTRnovel0.25
UCECchr13950213773'UTRnovel0.5
UCECchr1395021664Missense_MutationnovelY1297D0.24
UCECchr1395163178Missense_MutationnovelG751E0.31
UCECchr1395163131Missense_MutationnovelI767L0.2
UCECchr1395053159Missense_MutationNAM1131T0.36
UCECchr13950212523'UTRnovel0.36
UCECchr1395075478Missense_Mutationrs776637323E920D0.09
UCECchr1395178035SilentnovelT534T0.35
UCECchr1395186737SilentnovelR503R0.4
UCECchr1395234639Missense_MutationNAV168I0.33
UCECchr1395062736Missense_Mutationrs771698317D1112N0.18
UCECchr1395075553Splice_SitenovelX896_splice0.17
UCECchr1395115966Missense_MutationNAH831Y0.3
UCECchr13950212893'UTRnovel0.47
UCECchr1395021611SilentnovelQ1314Q0.16
UCECchr1395083178Frame_Shift_DelNAL883Wfs*70.3
UCECchr1395062827Missense_MutationNAK1081N0.42
UCECchr1395071667Nonsense_MutationNAE1069*0.42
UCECchr1395194938Splice_SiteNAX388_splice0.47
UCECchr1395043762Frame_Shift_Delrs756859429I1219Sfs*110.39
UCECchr1395021605Silentrs550257734S1316S0.32
UCECchr1395178074Missense_MutationNAE521D0.15
UCECchr1395075466Missense_MutationnovelQ924H0.41
UCECchr1395164447Missense_MutationnovelK702N0.35
UCECchr1395188534Missense_MutationnovelE424D0.38
UCECchr1395083165Missense_MutationnovelR887S0.45
UCECchr1395166321Missense_MutationNAG624D0.07
UCECchr1395188467Missense_MutationNAV447M0.51
UCECchr1395206741Missense_MutationNAG318R0.24
UCECchr13950205483'UTRnovel0.18
UCECchr1395034640Missense_MutationNAA1279T0.42
UCECchr1395071832Missense_MutationnovelI1014V0.41
UCECchr1395234666Missense_Mutationrs745785051V159I0.38
UCSchr1395194906Missense_Mutationrs749961375R398H0.19

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCAAMP0.12040.012126
CESCAMP0.17630.00028304
LIHCAMP0.12972.2054e-10
LUADAMP0.10270.027609
UCSAMP0.41070.0028198

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.00026

Kaplan-Meier Survival Analysis

ACC0.046

Kaplan-Meier Survival Analysis

PRAD0.046

Kaplan-Meier Survival Analysis

KIRP0.0045

Kaplan-Meier Survival Analysis

BLCA0.014

Kaplan-Meier Survival Analysis

CESC0.02

Kaplan-Meier Survival Analysis

UCEC0.0032

Kaplan-Meier Survival Analysis

GBM0.032

Kaplan-Meier Survival Analysis

LIHC0.0093

Kaplan-Meier Survival Analysis

LUAD0.036

Kaplan-Meier Survival Analysis

UVM0.00018

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000125257 (Gene tree)
Gene ID
10257
Gene Symbol
ABCC4
Alias
MRP4|EST170205|MOAT-B|MOATB
Full Name
ATP binding cassette subfamily C member 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
281,647 bases
Position
chr13:95,019,829-95,301,475
Accession
55
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22840641The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans.Vet Parasitol2012 Dec 21Yan Rdoi: 10.1016/j.vetpar.2012.06.038
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000642524ABCC4-2082256-ENSP0000049376652 (aa)-A0A2R8YDG7
ENST00000643816ABCC4-2113480--- (aa)--
ENST00000643051ABCC4-2096171-ENSP00000495513800 (aa)-A0A2R8Y6V8
ENST00000643556ABCC4-2103059-ENSP0000049493835 (aa)-A0A2R8Y5Z3
ENST00000484109ABCC4-205532--- (aa)--
ENST00000643842ABCC4-2125999-ENSP0000049386139 (aa)-Q8IWU1
ENST00000536256ABCC4-2062840-ENSP00000442024784 (aa)-O15439
ENST00000645532ABCC4-2162103-ENSP00000494431669 (aa)-A0A2R8YDC1
ENST00000474158ABCC4-204448--- (aa)--
ENST00000467685ABCC4-202357--- (aa)--
ENST00000471041ABCC4-203747--- (aa)--
ENST00000629385ABCC4-2072903XM_017020320ENSP00000487081859 (aa)XP_016875809O15439
ENST00000376887ABCC4-2015841XM_005254025ENSP000003660841325 (aa)XP_005254082O15439
ENST00000644880ABCC4-214562--- (aa)--
ENST00000646439ABCC4-2173863-ENSP000004947511278 (aa)-O15439
ENST00000644471ABCC4-2132225--- (aa)--
ENST00000645237ABCC4-2155856-ENSP000004946091325 (aa)-O15439
Gene Model
Click here to download ENSG00000125257's gene model file
Pathways
Pathway IDPathway NameSource
hsa01523Antifolate resistanceKEGG
hsa02010ABC transportersKEGG
hsa04024cAMP signaling pathwayKEGG
hsa04976Bile secretionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000125257Body Mass Index6.83377798271767E-517903300
ENSG00000125257Lipoproteins, VLDL3.16179372242532E-617903299
ENSG00000125257Lipoproteins, VLDL2.14679795383107E-817903299
ENSG00000125257Diabetic Nephropathies2.4000000E-00516775037
ENSG00000125257Diabetic Nephropathies4.4000000E-00516775037
ENSG00000125257Diabetic Nephropathies2.1000000E-00516775037
ENSG00000125257Alcoholism7.3249e-00522978509
ENSG00000125257Alcoholism4.21319e-00522978509
ENSG00000125257Respiratory Function Tests3.0480000E-005-
ENSG00000125257Respiratory Function Tests1.7910000E-005-
ENSG00000125257Erythrocyte Count4.8930000E-005-
ENSG00000125257Ankle Brachial Index8.6181300E-005-
ENSG00000125257Body Mass Index8.3675311E-005-
ENSG00000125257Platelet Function Tests2.4445400E-005-
ENSG00000125257Platelet Function Tests2.6300000E-006-
ENSG00000125257Platelet Function Tests2.5643400E-005-
ENSG00000125257Platelet Function Tests2.9003900E-005-
ENSG00000125257Platelet Function Tests2.7560900E-005-
ENSG00000125257Platelet Function Tests2.7560900E-005-
ENSG00000125257Platelet Function Tests1.3301100E-005-
ENSG00000125257Platelet Function Tests8.2300000E-006-
ENSG00000125257Platelet Function Tests2.7560900E-005-
ENSG00000125257Platelet Function Tests1.8750100E-005-
ENSG00000125257Child Development Disorders, Pervasive3.1238000E-005-
ENSG00000125257Arterial Pressure1.8030000E-006-
ENSG00000125257irinotecan2E-723478653
ENSG00000125257Carcinoma, Non-Small-Cell Lung2E-723478653
ENSG00000125257Breast Neoplasms2E-617903305
ENSG00000125257Bronchial Provocation Tests7E-625514360
ENSG00000125257Pulmonary Disease, Chronic Obstructive7E-625514360
ENSG00000125257Platelet Count7E-1222139419
ENSG00000125257Longevity1E-620834067
ENSG00000125257Metabolism1E-1924816252
ENSG00000125257Metabolism8E-2324816252
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000125257rs169506501395123178TResponse to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer23478653[8.4-109.0]30.2EFO_0004829|EFO_0003060
ENSG00000125257rs37655351395163281GAirway responsiveness in chronic obstructive pulmonary disease25514360[NR] unit increase0.065EFO_0006897|EFO_0000341
ENSG00000125257rs41484411395245953GPlatelet count22139419[2.94-5.29] 10^9/l increase4.117EFO_0004309
ENSG00000125257rs80021801395270511TBlood metabolite levels24816252[0.02-0.028] unit decrease0.024EFO_0005664
ENSG00000125257rs41484351395247462?Platelet count29403010[0.05-0.068] unit increase novel0.05872EFO_0004309
ENSG00000125257rs95248621395242373APlatelet count27863252[0.028-0.042] unit increase0.03508941EFO_0004309
ENSG00000125257rs41484351395247462APlatelet count27863252[0.062-0.088] unit increase0.07469402EFO_0004309
ENSG00000125257rs95165471395242683TPlateletcrit27863252[0.063-0.09] unit increase0.07672933EFO_0007985
ENSG00000125257rs47738601395248987TPlateletcrit27863252[0.035-0.05] unit increase0.04226349EFO_0007985
ENSG00000125257rs19266571395222702?Breast cancer17903305EFO_0000305
ENSG00000125257rs41485461395028031?Longevity20834067EFO_0004300
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125257's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002576platelet degranulation-TASProcess
GO:0005515protein binding29146910.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane15297306.25173977.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0010243response to organonitrogen compound-IEAProcess
GO:0014070response to organic cyclic compound-IEAProcess
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism-TASFunction
GO:0016020membrane19946888.HDAComponent
GO:0016020membrane21873635.IBAComponent
GO:0016020membrane15297306.IDAComponent
GO:0016021integral component of membrane-IEAComponent
GO:0016323basolateral plasma membrane24130369.IDAComponent
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activity7557451.NASFunction
GO:0031088platelet dense granule membrane15297306.IDAComponent
GO:0031088platelet dense granule membrane-TASComponent
GO:0032310prostaglandin secretion25173977.IDAProcess
GO:0042493response to drug-IEAProcess
GO:0042626ATPase activity, coupled to transmembrane movement of substances21873635.IBAFunction
GO:0048661positive regulation of smooth muscle cell proliferation-IEAProcess
GO:0055085transmembrane transport21873635.IBAProcess
GO:0055085transmembrane transport-TASProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0060271cilium assembly25173977.IMPProcess
GO:0099131ATP hydrolysis coupled ion transmembrane transport-IEAProcess
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