EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26821084Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma.Oncol Rep2016 AprKomatsu Hdoi: 10.3892/or.2016.4593
28474808Thyroid transcription factor-1-regulated microRNA-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells.Cancer Sci2017 JulGriesing Sdoi: 10.1111/cas.13271
26036188Overexpression of Transcription Termination Factor 1 is Associated with a Poor Prognosis in Patients with Colorectal Cancer.Ann Surg Oncol2015 DecUeda Mdoi: 10.1245/s10434-015-4652-7
25878335An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.Clin Cancer Res2015 Aug 1Cardnell RJdoi: 10.1158/1078-0432.CCR-14-3286
26912193Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome.Sci Rep2016 Feb 25Wood LWdoi: 10.1038/srep19857.
27354614Prognostic Factors Including the Expression of Thyroid Transcription Factor 1 (TTF1) in Patients Irradiated for Limited-disease Small Cell Lung Cancer.Anticancer Res2016 JulKsmann L-
26447895Various Antibody Clones of Napsin A, Thyroid Transcription Factor 1, and p40 and Comparisons With Cytokeratin 5 and p63 in Histopathologic Diagnostics of Non-Small Cell Lung Carcinoma.Appl Immunohistochem Mol Morphol2016 OctTran L-
28378892Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-small cell lung cancer.Genes Chromosomes Cancer2017 JulYoshimura Kdoi: 10.1002/gcc.22461
30194207TTF-1 Expression Predicts the Merit of Additional Antiangiogenic Treatment in Non-squamous Non-small Cell Lung Cancer.Anticancer Res2018 SepTakeuchi Adoi: 10.21873/anticanres.12882.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr9132401574SilentNAS416S0.06
BLCAchr9132390832Splice_SitenovelX663_splice0.12
BLCAchr9132400151Missense_MutationNAG492A0.23
BLCAchr9132402636SilentnovelL62L0.33
BLCAchr9132402469Missense_MutationnovelH118R0.16
BLCAchr9132401957Missense_Mutationrs375652888E289K0.22
BLCAchr9132400141SilentnovelV495V0.19
BLCAchr9132402162Missense_MutationnovelK220N0.31
BRCAchr9132402195Missense_MutationnovelE209D0.14
BRCAchr9132398322Silentrs747116451V532V0.18
BRCAchr9132401564Missense_MutationnovelD420H0.09
BRCAchr91323759033'UTRrs3676333160.27
BRCAchr9132401531Nonsense_MutationNAE431*0.1
CESCchr9132402091Missense_MutationnovelR244I0.21
CESCchr9132402711SilentNAF37F0.36
CESCchr9132390776Silentrs368907058V681V0.48
CESCchr9132401543Missense_Mutationrs763134689A427T0.37
CESCchr9132390755Missense_MutationNAK688N0.29
COADchr9132401908Missense_MutationNAA305V0.36
COADchr9132379111SilentNAF804F0.36
COADchr9132390666Missense_MutationnovelK718T0.06
COADchr9132388143Missense_MutationnovelE770K0.3
COADchr9132379094Missense_MutationnovelV810A0.09
COADchr9132375986Missense_MutationnovelG883C0.17
COADchr9132401509Missense_Mutationrs200157893R438Q0.21
COADchr9132401461Missense_Mutationrs141255148A454V0.32
COADchr9132402273SilentnovelA183A0.1
COADchr9132401986Frame_Shift_DelNAK279Rfs*1440.43
COADchr9132379146Splice_SitenovelX793_splice0.19
COADchr9132401986Frame_Shift_DelNAK279Rfs*1440.15
COADchr9132402322Frame_Shift_DelnovelK167Rfs*1010.09
COADchr9132390823Missense_Mutationrs199931383R666C0.22
COADchr9132401664Missense_MutationnovelK386N0.29
COADchr9132401664Missense_MutationnovelK386N0.32
COADchr9132400075Silentrs778850521Y517Y0.22
COADchr9132400123Missense_MutationnovelF501L0.05
COADchr9132401814Frame_Shift_Insrs772401251K337Efs*90.32
DLBCchr9132386597Missense_MutationnovelD779E0.21
ESCAchr9132402153Frame_Shift_InsnovelK224Efs*50.33
ESCAchr9132401986Frame_Shift_DelNAK279Rfs*1440.42
GBMchr9132392158SilentnovelL635L0.17
HNSCchr9132390828Missense_MutationnovelR664T0.81
HNSCchr9132402154Frame_Shift_Delrs765042099K223Rfs*450.25
HNSCchr9132402295Missense_MutationNAA176V0.34
HNSCchr9132375916Silentrs769761538*906*0.29
HNSCchr9132376128Silentrs540254981L835L0.35
HNSCchr9132401540Missense_MutationnovelM428V0.48
HNSCchr9132375965In_Frame_DelnovelP886_A889del0.58
HNSCchr9132401631SilentnovelV397V0.09
HNSCchr9132392143SilentnovelK640K0.23
HNSCchr9132398322Silentrs747116451V532V0.51
KIRCchr9132400183Frame_Shift_InsnovelD483Rfs*50.06
KIRCchr91323759093'UTRnovel0.5
KIRPchr9132402221In_Frame_DelnovelE195_S200del0.15
LAMLchr9132401475SilentnovelK449K0.11
LGGchr9132400059Missense_Mutationrs757246175R523W0.18
LGGchr9132401891Missense_Mutationrs763033895R311W0.4
LIHCchr9132401772SilentNAP350P0.68
LIHCchr9132401460Silentrs61741946A454A0.58
LIHCchr9132401985Frame_Shift_Insrs746659855K280Efs*100.29
LIHCchr9132402760Frame_Shift_DelnovelK21Sfs*230.29
LUADchr9132390822Missense_Mutationrs756664211R666H0.32
LUADchr9132402603SilentnovelC73C0.21
LUADchr9132390674Missense_MutationnovelK715N0.06
LUADchr9132401928Missense_MutationnovelQ298H0.05
LUADchr9132402275Missense_MutationNAA183S0.68
LUADchr9132401751Silentrs774520750Y357Y0.06
LUADchr9132402458Missense_MutationnovelD122H0.24
LUADchr9132401528Missense_MutationnovelG432C0.19
LUADchr9132392136Missense_MutationNAG643C0.38
LUADchr9132400129Missense_MutationnovelQ499H0.13
LUADchr9132376033Missense_MutationnovelY867C0.24
LUADchr9132402812Nonsense_MutationNAE4*0.14
LUADchr9132392208Splice_SitenovelX619_splice0.09
LUADchr9132390742Missense_MutationNAE693Q0.19
LUSCchr9132401918Missense_MutationNAE302Q0.05
LUSCchr9132375929Missense_Mutationrs773873964R902W0.5
LUSCchr9132401824Missense_MutationNAK333T0.18
LUSCchr9132398166SilentnovelR584R0.17
LUSCchr9132402600Frame_Shift_DelnovelD74Efs*570.2
LUSCchr9132402602Frame_Shift_DelnovelR71*0.19
OVchr9132401990Missense_MutationNAK278Q0.17
OVchr9132402103Missense_Mutationrs772587005S240W0.32
OVchr9132401983Frame_Shift_InsnovelK280Tfs*100.09
OVchr9132402494Nonsense_MutationnovelE110*0.04
OVchr9132398167Missense_MutationnovelR584M0.09
OVchr9132402527Missense_MutationnovelE99Q0.22
OVchr9132401635Missense_MutationNAS396F0.58
OVchr9132402182Missense_MutationnovelA214T0.09
OVchr9132388210Missense_MutationNAK747N0.39
PAADchr9132401718SilentnovelG368G0.18
PRADchr9132379126Nonsense_Mutationrs753268627Y799*0.43
PRADchr9132402128Missense_MutationnovelE232K0.38
PRADchr9132400210Silentrs144643349S472S0.25
PRADchr9132401873Missense_MutationNAH317Y0.31
READchr9132402009SilentnovelH271H0.1
READchr9132376046Nonsense_MutationNAR863*0.25
READchr9132396456Silentrs371348195F611F0.34
READchr9132402269Missense_MutationnovelD185N0.38
SARCchr9132390639Missense_MutationnovelA727D0.11
SARCchr9132392079Missense_MutationnovelS662R0.33
SARCchr9132401779Missense_MutationnovelA348V0.34
SKCMchr9132398232SilentNAS562S0.24
SKCMchr9132398181SilentNAI579I0.4
SKCMchr9132390747Missense_MutationNAP691L0.12
SKCMchr9132400149Missense_MutationNAS493A0.65
SKCMchr9132402384SilentNAQ146Q0.36
SKCMchr9132402126Missense_MutationnovelE232D0.34
SKCMchr9132400211Missense_MutationNAS472F0.39
SKCMchr9132402138SilentNAN228N0.43
SKCMchr9132388148Missense_MutationNAL768P0.06
SKCMchr9132402145Missense_MutationNAS226F0.15
SKCMchr9132388150SilentnovelS767S0.33
SKCMchr9132402145Missense_MutationNAS226F0.82
SKCMchr9132402355Missense_MutationnovelS156L0.35
SKCMchr9132402145Missense_MutationNAS226F0.41
SKCMchr9132379062Missense_MutationNAP821S0.8
SKCMchr9132390748Missense_MutationNAP691S0.83
SKCMchr9132401876SilentnovelL316L0.66
STADchr9132376023Silentrs201618724D870D0.19
STADchr9132401815Frame_Shift_DelNAK336Rfs*870.17
STADchr9132392200Missense_MutationnovelS621R0.08
STADchr9132401815Frame_Shift_DelNAK336Rfs*870.27
STADchr9132401815Frame_Shift_DelNAK336Rfs*870.23
STADchr9132402695Missense_MutationNAV43L0.18
STADchr9132402102Silentrs143824332S240S0.44
STADchr9132376161SilentNAI824I0.25
STADchr9132402001Frame_Shift_Delrs770528448K274Sfs*1490.35
STADchr9132402188Missense_MutationNAA212T0.23
STADchr9132402001Frame_Shift_Delrs770528448K274Sfs*1490.35
STADchr9132376043Missense_MutationNAD864N0.25
STADchr9132400195Missense_MutationnovelL477F0.11
STADchr9132401815Frame_Shift_DelNAK336Rfs*870.13
STADchr9132401814Frame_Shift_Insrs772401251K337Efs*90.35
STADchr9132402001Frame_Shift_Delrs770528448K274Sfs*1490.41
STADchr9132401986Frame_Shift_DelNAK279Rfs*1440.24
STADchr9132401621Nonsense_Mutationrs769896687R401*0.34
STADchr9132390647Missense_MutationNAE724D0.33
STADchr9132401641Missense_MutationNAL394R0.16
STADchr9132401986Frame_Shift_DelNAK279Rfs*1440.37
STADchr9132402720SilentNAH34H0.31
STADchr9132402238Missense_MutationNAE195G0.27
STADchr9132392140SilentnovelT641T0.6
STADchr9132400160Missense_Mutationrs757835009A489V0.19
STADchr9132401763Silentrs759510256L353L0.41
TGCTchr9132400037Missense_MutationnovelQ530R0.21
THCAchr9132400065SilentNAL521L0.34
UCECchr9132401510Nonsense_Mutationrs778557441R438*0.48
UCECchr9132402531Silentrs772573075D97D0.29
UCECchr9132390682Missense_Mutationrs752308539R713W0.23
UCECchr9132390659Missense_MutationnovelI720M0.3
UCECchr9132376046Nonsense_MutationNAR863*0.33
UCECchr9132390823Missense_Mutationrs199931383R666C0.3
UCECchr9132402471Missense_MutationNAK117N0.41
UCECchr9132396473Nonsense_MutationNAR606*0.16
UCECchr9132402416SilentNAL136L0.39
UCECchr9132386582Missense_MutationnovelD784E0.13
UCECchr9132401621Nonsense_Mutationrs769896687R401*0.12
UCECchr9132396483SilentnovelL602L0.04
UCECchr9132401498Missense_MutationNAT442A0.12
UCECchr9132401762Missense_Mutationrs142402338E354K0.29
UCECchr9132398219Missense_MutationNAL567M0.18
UCECchr9132402279SilentnovelQ181Q0.32
UCECchr9132401815Frame_Shift_DelNAK336Rfs*870.17
UCECchr9132402084SilentnovelA246A0.43
UCECchr9132402278Missense_Mutationrs368736523R182W0.48
UCECchr9132376161SilentNAI824I0.45
UCECchr9132400183SilentnovelS481S0.29
UCECchr9132401543Missense_Mutationrs763134689A427T0.26
UCECchr9132396449Frame_Shift_InsnovelN614Lfs*270.23
UCECchr9132386596Missense_Mutationrs530893039T780A0.33
UCECchr9132402350Missense_Mutationrs748912949A158T0.41
UCECchr9132402558Frame_Shift_InsnovelR89Efs*40.34
UCECchr9132402001Frame_Shift_Delrs770528448K274Sfs*1490.32
UCECchr9132390823Missense_Mutationrs199931383R666C0.48
UCECchr9132392199Missense_Mutationrs373368136E622K0.39
UCECchr9132401793Missense_MutationnovelE343D0.44
UCECchr9132401814Frame_Shift_Insrs772401251K337Efs*90.45
UCECchr9132396486Missense_MutationNAK601N0.36
UCECchr9132402001Frame_Shift_Delrs770528448K274Sfs*1490.35
UCECchr9132396456Missense_MutationnovelF611L0.39
UCECchr9132401600Missense_MutationnovelS408A0.19
UCECchr9132401827Missense_MutationnovelS332Y0.25
UCECchr9132390612Missense_MutationnovelQ736P0.39
UCECchr9132402153Frame_Shift_InsnovelK224Efs*50.34
UCECchr9132375963Silentrs199752397H890H0.43
UCECchr9132388169Missense_MutationNAA761V0.56
UCECchr9132400145Missense_MutationnovelA494V0.44
UCECchr9132402343Missense_MutationnovelH160R0.47
UCECchr9132402001Frame_Shift_Delrs770528448K274Sfs*1490.36
UCECchr9132390792Missense_Mutationrs751911549K676R0.24
UCECchr9132400173Missense_Mutationrs377409657D485N0.42
UCECchr9132402558Frame_Shift_InsnovelR89Efs*40.57
UCECchr9132401815Frame_Shift_DelNAK336Rfs*870.3
UCECchr9132375990Silentrs147089074S881S0.21
UCECchr9132402380Missense_MutationNAL148I0.5
UCECchr9132398321Missense_Mutationrs746380888A533T0.29
UCECchr9132392140SilentnovelT641T0.34
UCECchr9132402001Frame_Shift_Delrs770528448K274Sfs*1490.42
UCECchr91323758373'UTRnovel0.27
UCECchr9132375984SilentnovelG883G0.5
UCECchr9132376160Missense_Mutationrs776077995D825N0.33
UCECchr9132400062Missense_MutationnovelE522K0.43
UCECchr9132400174Silentrs199954975A484A0.3
UCECchr9132401509Missense_Mutationrs200157893R438Q0.39
UCSchr9132375943Frame_Shift_DelnovelL897Wfs*180.33
UCSchr9132401621Nonsense_Mutationrs769896687R401*0.28
UVMchr9132376139Missense_MutationnovelL832V0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.20190.070727
LAMLDEL0.01050.24147
LGGAMP0.05850.21332
LIHCDEL0.24860.12467
OVDEL0.55092.9521e-06
SARCDEL0.2140.00032085
THCADEL0.04010.24038
THYMDEL0.01630.022012
UCECDEL0.22080.0022334
UCSDEL0.60710.089783

Survival Analysis
CancerP-value Q-value
THYM0.0085

Kaplan-Meier Survival Analysis

KIRC0.00011

Kaplan-Meier Survival Analysis

STAD0.0087

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

UCS0.036

Kaplan-Meier Survival Analysis

SKCM0.048

Kaplan-Meier Survival Analysis

PRAD0.038

Kaplan-Meier Survival Analysis

BLCA0.017

Kaplan-Meier Survival Analysis

CESC0.0061

Kaplan-Meier Survival Analysis

LIHC0.00078

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000125482 (Gene tree)
Gene ID
7270
Gene Symbol
TTF1
Alias
N
Full Name
transcription termination factor 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
31,324 bases
Position
chr9:132,375,548-132,406,871
Accession
12397
RBP type
non-canonical RBP
Summary
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30854058Identification of B-cell translocation gene 1-controlled gene networks in diffuse large B-cell lymphoma: A study based on bioinformatics analysis.Oncol Lett2019 MarYan Wdoi: 10.3892/ol.2019.9900
9009277Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I.EMBO J1997 Jan 2Mason SW-
11532953NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines.EMBO J2001 Sep 3Strohner R-
29555014Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication.BMB Rep2018 JulPark SH-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000612514TTF1-2031780-ENSP00000481441390 (aa)-A0A087WY09
ENST00000334270TTF1-2013052XM_006717273ENSP00000333920905 (aa)XP_006717336Q15361
ENST00000461970TTF1-202581--- (aa)--
Gene Model
Click here to download ENSG00000125482's gene model file
Pathways
Pathway IDPathway NameSource
hsa04918Thyroid hormone synthesisKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000125482rs1164402399132381918?Plantar warts28928442[0.92-2.79] unit decrease1.8562EFO_0008406
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125482's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003677DNA binding-IEAFunction
GO:0003682chromatin binding21873635.IBAFunction
GO:0005634nucleus-IDAComponent
GO:0005634nucleus7597036.NASComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005886plasma membrane-IDAComponent
GO:0006353DNA-templated transcription, termination7597036.NASProcess
GO:0006363termination of RNA polymerase I transcription21873635.IBAProcess
GO:0006363termination of RNA polymerase I transcription-TASProcess
GO:0008156negative regulation of DNA replication-IEAProcess
GO:0044267cellular protein metabolic process-TASProcess
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