EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	63540880	Missense_Mutation	novel	E469K	0.6
BLCA	chr20	63542447	Silent	novel	I260I	0.22
BLCA	chr20	63547304	Nonsense_Mutation	novel	Q54*	0.29
BLCA	chr20	63540927	Missense_Mutation	rs369164878	A453V	0.06
BLCA	chr20	63542475	Missense_Mutation	NA	G251D	0.29
BLCA	chr20	63547356	Frame_Shift_Del	novel	*N37Tfs34**	0.32
BLCA	chr20	63547357	Missense_Mutation	novel	P36H	0.33
BRCA	chr20	63544266	Missense_Mutation	rs372015286	R147W	0.12
BRCA	chr20	63542192	Missense_Mutation	novel	R306L	0.17
CESC	chr20	63541505	Silent	novel	R354R	0.23
CESC	chr20	63540841	Missense_Mutation	rs748858814	A482T	0.44
CESC	chr20	63547394	Missense_Mutation	rs543252716	G24S	0.18
CESC	chr20	63547287	Silent	rs36032098	L59L	0.19
CESC	chr20	63540875	In_Frame_Ins	novel	R470_P471insQPQ	0.04
CESC	chr20	63547295	Frame_Shift_Ins	novel	*L57Sfs5**	0.1
COAD	chr20	63540865	Missense_Mutation	NA	A474T	0.16
COAD	chr20	63547399	Missense_Mutation	rs777121276	A22V	0.53
COAD	chr20	63547271	Missense_Mutation	rs764471349	R65W	0.18
COAD	chr20	63540945	Missense_Mutation	novel	R447H	0.34
COAD	chr20	63542554	Missense_Mutation	rs142975228	R225W	0.29
COAD	chr20	63542310	Missense_Mutation	NA	L267F	0.18
COAD	chr20	63543438	Missense_Mutation	NA	A174V	0.2
COAD	chr20	63542194	Missense_Mutation	novel	M305I	0.07
COAD	chr20	63540826	Missense_Mutation	rs146373271	H487Y	0.33
COAD	chr20	63543344	Missense_Mutation	novel	Q205H	0.42
COAD	chr20	63542308	Silent	rs761533969	L267L	0.3
COAD	chr20	63542460	Missense_Mutation	rs137951199	A256V	0.17
COAD	chr20	63547402	Missense_Mutation	rs564747393	P21L	0.27
ESCA	chr20	63547392	Silent	rs780114763	G24G	0.31
ESCA	chr20	63540944	Silent	novel	R447R	0.52
ESCA	chr20	63541204	Missense_Mutation	novel	Q424H	0.16
GBM	chr20	63541510	Missense_Mutation	rs61740255	A353T	0.49
GBM	chr20	63542231	Missense_Mutation	rs533446182	S293L	0.47
GBM	chr20	63547272	Silent	rs140773907	A64A	0.26
GBM	chr20	63542554	Missense_Mutation	rs142975228	R225W	0.22
GBM	chr20	63541590	Missense_Mutation	novel	P326L	0.25
HNSC	chr20	63542566	Missense_Mutation	novel	D221Y	0.38
HNSC	chr20	63547339	Missense_Mutation	NA	P42L	0.23
HNSC	chr20	63541270	Silent	novel	V402V	0.09
KIRC	chr20	63543341	Missense_Mutation	NA	N206K	0.31
LGG	chr20	63547251	Silent	NA	S71S	0.47
LGG	chr20	63541207	Silent	novel	G423G	0.44
LGG	chr20	63547399	Missense_Mutation	rs777121276	A22V	0.49
LGG	chr20	63541331	Missense_Mutation	rs374780062	P382L	0.39
LIHC	chr20	63540931	Missense_Mutation	novel	P452S	0.15
LIHC	chr20	63547262	Missense_Mutation	rs149894938	G68R	0.48
LIHC	chr20	63541506	Missense_Mutation	rs775845157	R354Q	0.2
LUAD	chr20	63541470	Missense_Mutation	rs757824796	V366A	0.4
LUAD	chr20	63541348	Splice_Site	novel	X377_splice	0.18
LUAD	chr20	63541236	Missense_Mutation	rs780151368	V414I	0.13
LUAD	chr20	63547259	Missense_Mutation	NA	E69K	0.24
LUAD	chr20	63540831	Missense_Mutation	NA	R485I	0.12
LUAD	chr20	63543474	Missense_Mutation	NA	A162D	0.24
LUAD	chr20	63541213	Silent	NA	T421T	0.09
LUAD	chr20	63543470	Missense_Mutation	novel	Q163H	0.31
LUAD	chr20	63543383	Silent	NA	E192E	0.33
LUAD	chr20	63541290	Missense_Mutation	NA	E396K	0.1
LUAD	chr20	63541326	Frame_Shift_Ins	novel	*S384Qfs13**	0.19
LUAD	chr20	63541327	Missense_Mutation	novel	S383R	0.78
LUSC	chr20	63543477	Missense_Mutation	rs140476273	R161Q	0.18
LUSC	chr20	63547130	Frame_Shift_Del	novel	*V102Lfs92**	0.13
LUSC	chr20	63543332	Silent	novel	L209L	0.1
LUSC	chr20	63542296	Silent	NA	A271A	0.44
LUSC	chr20	63540935	Silent	novel	A450A	0.41
LUSC	chr20	63541510	Missense_Mutation	novel	A353S	0.33
PAAD	chr20	63541274	Missense_Mutation	rs139360881	R401H	0.17
PAAD	chr20	63541533	Missense_Mutation	rs751206072	R345H	0.15
PRAD	chr20	63541288	Missense_Mutation	NA	E396D	0.17
PRAD	chr20	63547242	Silent	rs780031609	R74R	0.06
PRAD	chr20	63541249	Silent	novel	V409V	0.35
PRAD	chr20	63542192	Missense_Mutation	rs749399265	R306H	0.19
READ	chr20	63547318	Missense_Mutation	NA	C49F	0.37
READ	chr20	63542204	Missense_Mutation	rs760106125	T302M	0.47
READ	chr20	63542165	Missense_Mutation	NA	G315V	0.14
READ	chr20	63547408	Missense_Mutation	NA	I19N	0.42
SARC	chr20	63542230	Silent	rs756318161	S293S	0.17
SKCM	chr20	63542293	Silent	rs560487403	K272K	0.42
SKCM	chr20	63543404	Silent	NA	R185R	0.14
SKCM	chr20	63542578	Missense_Mutation	novel	A217T	0.31
SKCM	chr20	63542579	Splice_Region	novel	K216K	0.32
SKCM	chr20	63541540	Missense_Mutation	novel	E343K	0.15
SKCM	chr20	63541541	Silent	novel	E342E	0.15
SKCM	chr20	63547197	Silent	rs377302688	F89F	0.25
SKCM	chr20	63547296	Silent	NA	F56F	0.23
SKCM	chr20	63542566	Missense_Mutation	novel	D221N	0.58
SKCM	chr20	63544279	Silent	NA	G142G	0.75
SKCM	chr20	63547259	Missense_Mutation	NA	E69K	0.5
SKCM	chr20	63542308	Silent	NA	L267L	0.43
SKCM	chr20	63544287	Missense_Mutation	rs757706555	E140K	0.6
SKCM	chr20	63540886	Missense_Mutation	novel	P467S	0.21
SKCM	chr20	63547331	Missense_Mutation	NA	P45S	0.58
SKCM	chr20	63542274	Missense_Mutation	novel	G279S	0.29
STAD	chr20	63540947	Silent	rs764818396	P446P	0.08
STAD	chr20	63542265	Missense_Mutation	rs751298544	H282Y	0.45
STAD	chr20	63547398	Silent	rs768842767	A22A	0.43
STAD	chr20	63540870	Missense_Mutation	NA	S472C	0.15
STAD	chr20	63547123	Missense_Mutation	rs373892181	T114M	0.06
STAD	chr20	63543363	Missense_Mutation	NA	A199V	0.14
UCEC	chr20	63541224	Missense_Mutation	NA	E418K	0.35
UCEC	chr20	63542542	Missense_Mutation	NA	E229K	0.71
UCEC	chr20	63542192	Missense_Mutation	rs749399265	R306H	0.37
UCEC	chr20	63542542	Missense_Mutation	NA	E229K	0.39
UCEC	chr20	63543405	Missense_Mutation	novel	R185Q	0.4
UCEC	chr20	63547448	Missense_Mutation	novel	R6G	0.53
UCEC	chr20	63541295	Missense_Mutation	rs146362549	A394V	0.16
UCEC	chr20	63542214	Missense_Mutation	NA	Y299H	0.16
UCEC	chr20	63543464	Missense_Mutation	novel	K165N	0.1
UCEC	chr20	63544287	Missense_Mutation	rs757706555	E140K	0.47
UCEC	chr20	63544302	Missense_Mutation	novel	L135I	0.36
UCEC	chr20	63541285	Silent	novel	A397A	0.43
UCEC	chr20	63540980	Silent	rs745966576	T435T	0.5
UCEC	chr20	63541249	Silent	novel	V409V	0.46
UCEC	chr20	63541522	Missense_Mutation	rs374425555	R349W	0.41
UCEC	chr20	63540878	Silent	novel	E469E	0.3
UCEC	chr20	63542542	Missense_Mutation	NA	E229K	0.36
UCEC	chr20	63547275	Silent	rs202085727	T63T	0.31
UCEC	chr20	63543334	Silent	novel	L209L	0.09
UCEC	chr20	63541238	Missense_Mutation	novel	G413D	0.09
UCEC	chr20	63543313	Splice_Site	novel	X215_splice	0.46
UCEC	chr20	63542553	Missense_Mutation	rs761225720	R225Q	0.33
UCEC	chr20	63542184	Missense_Mutation	rs748368398	N309D	0.31
UCEC	chr20	63547271	Missense_Mutation	rs764471349	R65W	0.09
UCEC	chr20	63542263	Silent	rs766255803	H282H	0.35
UCEC	chr20	63544325	Missense_Mutation	rs370061091	R127Q	0.34
UCEC	chr20	63547182	Silent	rs549550690	S94S	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0305	0.00029523
CHOL	DEL	0.0278	3.3987e-23
DLBC	DEL	0.0208	0.011841
HNSC	DEL	0.0402	7.0766e-07
KIRC	DEL	0	2.3538e-09
KIRP	DEL	0	1.462e-09
LIHC	AMP	0.2892	0.013414
LUAD	AMP	0.3682	8.1427e-15
LUAD	DEL	0.0504	0.0024765
LUSC	DEL	0.1058	2.5882e-07
MESO	DEL	0	2.434e-07
OV	AMP	0.6321	5.6628e-10
PRAD	AMP	0.0589	0.07085
READ	AMP	0.8667	0.033971
READ	DEL	0.0061	2.1758e-10
SARC	AMP	0.3035	0.033553
SKCM	AMP	0.4496	0.058021
TGCT	DEL	0.0733	0.00046313
UCS	DEL	0.0179	0.0051125

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0014	Kaplan-Meier Survival Analysis
STAD	0.00092	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.0013	Kaplan-Meier Survival Analysis
LUSC	0.039	Kaplan-Meier Survival Analysis
COAD	0.0028	Kaplan-Meier Survival Analysis
PAAD	0.022	Kaplan-Meier Survival Analysis
BLCA	0.0016	Kaplan-Meier Survival Analysis
READ	0.028	Kaplan-Meier Survival Analysis
LAML	0.021	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
OV	0.0098	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000125508 (Gene tree)
Gene ID: 6725
Gene Symbol: SRMS
Alias: SRM|dJ697K14.1|PTK70|C20orf148
Full Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 7,581 bases
Position: chr20:63,539,924-63,547,504
Accession: 11298
RBP type: non-canonical RBP
Summary: (Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites) is a Protein Coding gene. Diseases associated with SRMS include Skeletal Muscle Cancer and Muscle Cancer. Among its related pathways are Signaling by GPCR and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PTK6.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000217188	SRMS-201	1516	-	ENSP00000217188	488 (aa)	-	Q9H3Y6

Gene Model

Click here to download ENSG00000125508's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000125508	Platelet Function Tests	6.3500000E-006	-
ENSG00000125508	Magnesium	1.9270000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125508's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004713	protein tyrosine kinase activity	25897081.	EXP	Function
GO:0004713	protein tyrosine kinase activity	23822091.29496907.	IDA	Function
GO:0004715	non-membrane spanning protein tyrosine kinase activity	21873635.	IBA	Function
GO:0005102	signaling receptor binding	21873635.	IBA	Function
GO:0005515	protein binding	23822091.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	23822091.29496907.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	21873635.	IBA	Process
GO:0009968	negative regulation of signal transduction	-	TAS	Process
GO:0018108	peptidyl-tyrosine phosphorylation	29496907.	IDA	Process
GO:0030154	cell differentiation	21873635.	IBA	Process
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	21873635.	IBA	Component
GO:0038083	peptidyl-tyrosine autophosphorylation	21873635.	IBA	Process
GO:0038083	peptidyl-tyrosine autophosphorylation	23822091.	IDA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.