EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21702043	Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer.	Int J Cancer	2012 Jun 1	Zuzga DS	doi: 10.1002/ijc.26257
19081821	Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.	Mol Oncol	2008 Jun	Hasegawa Y	doi: 10.1016/j.molonc.2008.03.009.
25051011	TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).	PLoS One	2014 Jul 22	Tang M	doi: 10.1371/journal.pone.0102967
20802179	Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth.	Am J Pathol	2010 Oct	Kang N	doi: 10.2353/ajpath.2010.100187
23685951	Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP).	Acta Pharmacol Sin	2013 Aug	Zhang JW	doi: 10.1038/aps.2013.15
25543053	Serine phosphorylation of vasodilator-stimulated phosphoprotein (VASP) regulates colon cancer cell survival and apoptosis.	Life Sci	2015 Feb 15	Ali M	doi: 10.1016/j.lfs.2014.12.018
26336132	The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma.	Oncotarget	2015 Oct 6	Dppler H	doi: 10.18632/oncotarget.4965.
22320863	HIF-1α acts downstream of TNF-α to inhibit vasodilator-stimulated phosphoprotein expression and modulates the adhesion and proliferation of breast cancer cells.	DNA Cell Biol	2012 Jun	Su K	doi: 10.1089/dna.2011.1563
18813837	Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells.	Oncol Rep	2008 Oct	Han G	-
19115233	Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.	J Cell Physiol	2009 May	Bae YH	doi: 10.1002/jcp.21677.
29460479	Label-Free Quantitative Phosphoproteomics Reveals Regulation of Vasodilator-Stimulated Phosphoprotein upon Stathmin-1 Silencing in a Pair of Isogenic Colorectal Cancer Cell Lines.	Proteomics	2018 Apr	Tan HT	doi: 10.1002/pmic.201700242

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	45521345	Missense_Mutation	novel	A123T	0.55
BLCA	chr19	45523668	Silent	novel	E282E	0.26
BLCA	chr19	45517957	Missense_Mutation	novel	G69D	0.22
BRCA	chr19	45524601	Missense_Mutation	rs374049612	E330K	0.05
BRCA	chr19	45521319	Splice_Region	novel		0.25
BRCA	chr19	45526198	3'UTR	novel		0.2
BRCA	chr19	45517750	Silent	novel	Q31Q	0.09
BRCA	chr19	45523860	Missense_Mutation	novel	R298T	0.13
CESC	chr19	45524654	Silent	NA	V347V	0.6
CESC	chr19	45524618	Silent	novel	T335T	0.13
CESC	chr19	45517761	Missense_Mutation	rs571015875	R35H	0.18
CESC	chr19	45522757	Missense_Mutation	NA	E254K	0.17
CHOL	chr19	45524601	Nonsense_Mutation	novel	E330*	0.06
COAD	chr19	45526220	3'UTR	novel		0.38
COAD	chr19	45526203	3'UTR	novel		0.37
COAD	chr19	45523878	Splice_Site	novel	X304_splice	0.18
COAD	chr19	45522219	Splice_Site	novel	X160_splice	0.42
COAD	chr19	45522772	Missense_Mutation	NA	G259R	0.1
COAD	chr19	45521330	Frame_Shift_Del	novel	*P119Lfs34**	0.18
COAD	chr19	45525990	Missense_Mutation	novel	E364D	0.08
COAD	chr19	45522354	Frame_Shift_Del	NA	*A167Lfs101**	0.36
ESCA	chr19	45522542	Silent	novel	A227A	0.5
GBM	chr19	45524616	Missense_Mutation	NA	T335A	0.06
GBM	chr19	45517823	Missense_Mutation	novel	P56T	0.58
GBM	chr19	45524116	Missense_Mutation	novel	W310C	0.13
HNSC	chr19	45517799	Missense_Mutation	NA	R48C	0.09
HNSC	chr19	45524141	Missense_Mutation	novel	R319W	0.5
KIRC	chr19	45521350	Silent	NA	L124L	0.38
KIRP	chr19	45526258	3'UTR	novel		0.48
LIHC	chr19	45518085	Missense_Mutation	NA	A112S	0.38
LUAD	chr19	45517982	Silent	novel	P77P	0.17
LUAD	chr19	45525989	Missense_Mutation	novel	E364G	0.12
LUSC	chr19	45523873	Missense_Mutation	novel	Q302H	0.14
LUSC	chr19	45517998	Missense_Mutation	novel	R83G	0.21
LUSC	chr19	45517766	Missense_Mutation	NA	Q37K	0.31
LUSC	chr19	45517752	Missense_Mutation	NA	A32V	0.44
LUSC	chr19	45517753	Silent	rs777159219	A32A	0.41
LUSC	chr19	45525988	Missense_Mutation	novel	E364Q	0.15
OV	chr19	45523666	Nonsense_Mutation	novel	E282*	0.07
OV	chr19	45525971	Frame_Shift_Ins	novel	*E358Dfs21**	0.1
OV	chr19	45517787	Missense_Mutation	rs777492777	A44T	0.21
SARC	chr19	45526561	3'UTR	novel		0.07
SARC	chr19	45524106	Missense_Mutation	rs371283026	R307Q	0.38
SKCM	chr19	45518022	Missense_Mutation	NA	L91F	0.25
SKCM	chr19	45526206	3'UTR	novel		0.65
STAD	chr19	45517722	Missense_Mutation	rs749426631	R22Q	0.21
STAD	chr19	45524106	Missense_Mutation	rs371283026	R307Q	0.29
STAD	chr19	45524108	Silent	NA	R308R	0.29
STAD	chr19	45526199	3'UTR	novel		0.3
THYM	chr19	45526854	3'UTR	novel		0.48
UCEC	chr19	45517761	Missense_Mutation	rs571015875	R35H	0.3
UCEC	chr19	45523656	Silent	novel	T278T	0.48
UCEC	chr19	45522760	Missense_Mutation	novel	S255G	0.2
UCEC	chr19	45526197	3'UTR	novel		0.29
UCEC	chr19	45522204	Silent	novel	R155R	0.32
UCEC	chr19	45526563	3'UTR	novel		0.44
UCEC	chr19	45526320	3'UTR	novel		0.54
UCEC	chr19	45517741	Silent	rs373932046	T28T	0.55
UCEC	chr19	45522543	Missense_Mutation	rs760633493	A228T	0.53
UCEC	chr19	45526185	3'UTR	novel		0.56
UCEC	chr19	45517978	Frame_Shift_Del	novel	*N78Tfs33**	0.47
UCEC	chr19	45526498	3'UTR	novel		0.36
UCEC	chr19	45526836	3'UTR	novel		0.93
UCEC	chr19	45526649	3'UTR	novel		0.24
UCEC	chr19	45522766	Nonsense_Mutation	NA	R257*	0.39
UCEC	chr19	45524121	Missense_Mutation	rs759805062	K312T	0.3
UCEC	chr19	45526308	3'UTR	novel		0.48
UCEC	chr19	45522353	Frame_Shift_Ins	NA	*A167Rfs88**	0.29
UCEC	chr19	45521364	Missense_Mutation	NA	V129A	0.54
UCEC	chr19	45522723	Missense_Mutation	novel	E242D	0.33
UCEC	chr19	45522795	Missense_Mutation	novel	E266D	0.36
UCEC	chr19	45518031	Missense_Mutation	rs529146911	G94S	0.36
UCEC	chr19	45522786	Silent	novel	L263L	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0746	0.027508
KIRP	DEL	0.0451	0.054726
READ	DEL	0.0667	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1964	0.12448

Survival Analysis

Cancer	P-value	Q-value
THYM	0.023	Kaplan-Meier Survival Analysis
KIRC	0.0029	Kaplan-Meier Survival Analysis
SARC	0.003	Kaplan-Meier Survival Analysis
MESO	0.0002	Kaplan-Meier Survival Analysis
ACC	0.027	Kaplan-Meier Survival Analysis
UCS	0.018	Kaplan-Meier Survival Analysis
HNSC	0.029	Kaplan-Meier Survival Analysis
LUSC	0.017	Kaplan-Meier Survival Analysis
COAD	0.034	Kaplan-Meier Survival Analysis
PAAD	0.0044	Kaplan-Meier Survival Analysis
BLCA	0.014	Kaplan-Meier Survival Analysis
LAML	0.013	Kaplan-Meier Survival Analysis
GBM	0.013	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
DLBC	0.039	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.02	Kaplan-Meier Survival Analysis
UVM	0.0087	Kaplan-Meier Survival Analysis
OV	0.026	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000125753 (Gene tree)
Gene ID: 7408
Gene Symbol: VASP
Alias: N
Full Name: vasodilator stimulated phosphoprotein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 20,411 bases
Position: chr19:45,506,579-45,526,989
Accession: 12652
RBP type: non-canonical RBP
Summary: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16531412	Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration.	J Biol Chem	2006 May 5	Zhang Y	-
22395610	Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.	Nat Commun	2012 Mar 6	Fraley SI	doi: 10.1038/ncomms1711.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590603	VASP-210	388	-	ENSP00000467773	35 (aa)	-	K7EQD0
ENST00000586014	VASP-202	1725	-	ENSP00000467005	103 (aa)	-	K7ENL7
ENST00000592139	VASP-211	424	-	ENSP00000464742	46 (aa)	-	K7EIG8
ENST00000587444	VASP-204	240	-	-	- (aa)	-	-
ENST00000590459	VASP-209	405	-	-	- (aa)	-	-
ENST00000588482	VASP-207	804	-	ENSP00000466319	183 (aa)	-	K7EM16
ENST00000588463	VASP-206	655	-	-	- (aa)	-	-
ENST00000589627	VASP-208	696	-	ENSP00000467061	59 (aa)	-	K7ENR7
ENST00000588273	VASP-205	318	-	-	- (aa)	-	-
ENST00000245932	VASP-201	2305	XM_005259199	ENSP00000245932	380 (aa)	XP_005259256	P50552
ENST00000586619	VASP-203	655	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000125753's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04530	Tight junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000125753	Blood Pressure	4.2400762E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125753's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001843	neural tube closure	-	IEA	Process
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	8836115.16189514.16631741.16940418.17599063.20195357.21423205.21911467.23153535.24076653.25416956.	IPI	Function
GO:0005522	profilin binding	17914456.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005923	bicellular tight junction	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	-	IDA	Component
GO:0007411	axon guidance	-	TAS	Process
GO:0008154	actin polymerization or depolymerization	-	IEA	Process
GO:0015629	actin cytoskeleton	7828592.	TAS	Component
GO:0017124	SH3 domain binding	-	IEA	Function
GO:0030838	positive regulation of actin filament polymerization	23153535.	IDA	Process
GO:0031258	lamellipodium membrane	-	IEA	Component
GO:0031527	filopodium membrane	-	IEA	Component
GO:0034329	cell junction assembly	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051289	protein homotetramerization	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.