EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28088229Clinicopathologic significance of TRAP1 expression in colorectal cancer: a large scale study of human colorectal adenocarcinoma tissues.Diagn Pathol2017 Jan 14Pak MGdoi: 10.1186/s13000-017-0598-3.
19490362Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression.J Neurochem2009 JulKubota Kdoi: 10.1111/j.1471-4159.2009.06099.x
25564869Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells.Oncotarget2014 Dec 15Guzzo G-
23842546Landscape of the mitochondrial Hsp90 metabolome in tumours.Nat Commun2013Chae YCdoi: 10.1038/ncomms3139.
18790094cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.Biochim Biophys Acta2008 DecRusso Adoi: 10.1016/j.bbagrm.2008.08.006
28678347TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination.J Pathol2017 SepSisinni Ldoi: 10.1002/path.4936
26517089Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer.Oncotarget2015 Dec 29Zhang Bdoi: 10.18632/oncotarget.6252.
21878357TRAP-1, the mitochondrial Hsp90.Biochim Biophys Acta2012 MarAltieri DCdoi: 10.1016/j.bbamcr.2011.08.007
25493016Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer.World J Gastroenterol2014 Dec 7Chen Rdoi: 10.3748/wjg.v20.i45.17037.
19948822Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.Am J Pathol2010 JanLeav Idoi: 10.2353/ajpath.2010.090521
26722505Expression of tumor necrosis factor receptor-associated protein 1 and its clinical significance in kidney cancer.Int J Clin Exp Pathol2015 Oct 1Si T-
25438697TRAP1 shows clinical significance and promotes cellular migration and invasion through STAT3/MMP2 pathway in human esophageal squamous cell cancer.J Genet Genomics2014 Oct 20Ou Ydoi: 10.1016/j.jgg.2014.08.004
20499060Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy.Cancer Immunol Immunother2010 SepNguyen MCdoi: 10.1007/s00262-010-0858-5
26071104TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways.Biochim Biophys Acta2015 OctAgliarulo Idoi: 10.1016/j.bbamcr.2015.05.034
23139614Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer.World J Gastroenterol2012 Nov 7Gao JYdoi: 10.3748/wjg.v18.i41.5965.
27754870Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.J Biol Chem2016 Nov 25Lisanti S-
27977010TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.Cell Death Dis2016 Dec 15Amoroso MRdoi: 10.1038/cddis.2016.400.
28427560Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation.Adv Protein Chem Struct Biol2017Amoroso MRdoi: 10.1016/bs.apcsb.2017.01.004
27662365TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma.Cell Death Differ2016 Nov 1Lettini Gdoi: 10.1038/cdd.2016.67

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr163677761Intronnovel0.31
BLCAchr163677701Intronnovel0.47
BLCAchr163689138Splice_SitenovelX83_splice0.37
BRCAchr163664412Silentrs780424369S477S0.58
BRCAchr163679753Missense_MutationNAS170C0.26
BRCAchr163671736Missense_MutationNAE407D0.48
BRCAchr163690934Missense_Mutationrs148589352R47Q0.11
CESCchr163665982Nonsense_MutationNAQ458*0.44
CESCchr163689120Frame_Shift_DelnovelH88Qfs*460.09
CESCchr163666074Missense_Mutationrs138210295I427N0.35
CESCchr163664334Frame_Shift_DelnovelN504Tfs*140.12
CESCchr163671734Missense_MutationnovelS408N0.09
CESCchr163658834Missense_Mutationrs139636268R658C0.29
CHOLchr163679750Missense_Mutationrs759416487N171S0.32
COADchr163674426SilentnovelA319A0.39
COADchr163658831Missense_Mutationrs764916149A659T0.17
COADchr163676045Missense_Mutationrs376597215R269W0.14
COADchr163671759Missense_MutationnovelL400I0.33
COADchr163675371Missense_Mutationrs757572551V281I0.82
COADchr163666038Frame_Shift_DelnovelK439Vfs*30.06
COADchr163664386Missense_MutationnovelY486C0.17
COADchr163658834Missense_Mutationrs139636268R658C0.29
COADchr163663477Missense_Mutationrs765500192T552M0.35
COADchr163658853Silentrs756385239I651I0.29
COADchr163664360Missense_Mutationrs113510154R495C0.33
COADchr163686084Missense_Mutationrs61758086R128H0.17
COADchr163674449Nonsense_MutationnovelE312*0.3
COADchr163686082Missense_MutationNAH129Y0.32
COADchr163664428Missense_MutationNAS472F0.18
COADchr163674365Missense_Mutationrs775599442R340C0.2
COADchr163676100SilentnovelG250G0.06
GBMchr163686010Frame_Shift_DelnovelT153Pfs*110.07
GBMchr163674380Missense_MutationnovelA335S0.13
GBMchr163662129Missense_MutationNAT600P0.25
GBMchr163662024Missense_Mutationrs368514972A635T0.47
GBMchr163674344Missense_Mutationrs754378125D347N0.24
GBMchr163674338Splice_SitenovelX348_splice0.31
GBMchr163661998Missense_MutationnovelE643D0.08
HNSCchr163676127Silentrs748044609I241I0.26
HNSCchr163662054Nonsense_MutationnovelQ625*0.25
HNSCchr163674417Silentrs562153382H322H0.07
HNSCchr163672788SilentnovelL359L0.29
HNSCchr163677626Missense_Mutationrs763585509E192D0.14
HNSCchr163689109Silentrs370347742A92A0.33
KIRCchr163676075Missense_MutationNAS259P0.31
KIRCchr163677663Splice_Regionnovel0.16
KIRPchr163677497Splice_SitenovelX235_splice0.38
KIRPchr163662966Splice_Regionrs749434626A570A0.38
LIHCchr163662965Missense_Mutationrs549044388A571T0.33
LIHCchr163666008Missense_Mutationrs764205911R449Q0.45
LIHCchr163689090Missense_MutationNAD99Y0.43
LIHCchr163663464SilentnovelV556V0.5
LUADchr163674426Silentrs747215207A319A0.61
LUADchr163690935Nonsense_Mutationrs141984778R47*0.21
LUADchr163690881Missense_Mutationrs772715172E65K0.07
LUADchr163675360Silentrs755984821P284P0.19
LUADchr163674357Missense_Mutationrs143857142I342M0.19
LUSCchr163674387SilentnovelK332K0.09
LUSCchr163674386Missense_MutationnovelT333S0.18
LUSCchr163664394SilentnovelL483L0.16
OVchr163658158Missense_MutationnovelL696V0.84
OVchr163658149Nonsense_MutationnovelK699*0.33
OVchr163674486Missense_MutationnovelW299C0.25
OVchr163663463Missense_MutationNAD557N0.22
OVchr163663456Missense_MutationnovelY559C0.1
PAADchr163663513Missense_Mutationrs141361125R540H0.09
PAADchr163672702Missense_Mutationrs148180859R388Q0.28
PAADchr163674436Missense_Mutationrs151069865R316H0.14
PAADchr163690953Missense_MutationnovelA41S0.18
PCPGchr163677662Splice_Regionnovel0.39
PRADchr163677583Frame_Shift_DelnovelG204Sfs*60.1
PRADchr163663496Missense_Mutationrs143144399K546Q0.31
PRADchr163662940Missense_Mutationrs112776374T579M0.5
PRADchr163679743SilentnovelG173G0.36
PRADchr163686031Nonsense_MutationnovelQ146*0.4
READchr163677734Intronnovel0.5
READchr163666057Frame_Shift_InsnovelD433Rfs*30.54
READchr163675372Silentrs377042927F280F0.31
READchr163675336Missense_MutationnovelM292I0.26
SKCMchr163677656Splice_RegionNAA182A0.35
SKCMchr163675372Silentrs377042927F280F0.12
SKCMchr163690952Missense_Mutationrs765388146A41V0.39
SKCMchr163679729Missense_MutationNAS178L0.13
SKCMchr163662000Missense_Mutationrs145014945E643K0.36
STADchr163674346Missense_MutationnovelP346H0.2
STADchr163686127Missense_Mutationrs192245771R114W0.28
STADchr163665977Missense_MutationnovelE459D0.06
STADchr163690885Silentrs376485209T63T0.19
STADchr163672698Splice_SitenovelX389_splice0.3
STADchr163689121SilentNAH88H0.28
STADchr163662929Missense_Mutationrs371118456M583V0.28
STADchr163663497SilentNAK545K0.38
STADchr163686089Frame_Shift_DelnovelK126Nfs*380.17
STADchr163658225Silentrs776747983Y673Y0.14
STADchr163677700Intronnovel0.12
STADchr163674427Missense_Mutationrs200973932A319V0.13
STADchr163690906SilentnovelG56G0.49
STADchr163677536SilentnovelA222A0.22
STADchr163674367Missense_MutationNAI339N0.12
STADchr163674365Missense_Mutationrs775599442R340C0.12
STADchr163666058Frame_Shift_DelnovelD433Mfs*210.45
STADchr163666053Missense_MutationNAA434V0.25
STADchr163676064Missense_MutationNAK262N0.22
STADchr163666110Missense_Mutationrs371962678R415Q0.38
STADchr163664316SilentNAE509E0.13
UCECchr163658825Missense_Mutationrs776306147E661K0.4
UCECchr163676051Missense_Mutationrs148151713E267K0.34
UCECchr163690953Missense_MutationnovelA41S0.38
UCECchr163664293Missense_MutationnovelM517T0.58
UCECchr163665985Missense_Mutationrs146643872E457K0.42
UCECchr163662126Missense_MutationnovelL601I0.41
UCECchr163671728Missense_MutationnovelL410P0.19
UCECchr163674357Silentrs143857142I342I0.11
UCECchr163666084Missense_MutationnovelK424Q0.43
UCECchr163671733Silentrs377663088S408S0.27
UCECchr163671753Missense_MutationNAR402W0.26
UCECchr163663559Missense_MutationnovelL525F0.31
UCECchr163686045Missense_MutationnovelM141T0.16
UCECchr163690838Missense_MutationnovelE79G0.43
UCECchr163674365Missense_Mutationrs775599442R340C0.5
UCECchr163662060Missense_Mutationrs192869535R623C0.42
UCECchr163662948Missense_MutationnovelE576D0.56
UCECchr163674426SilentnovelA319A0.47
UCECchr163690961Missense_MutationnovelR38M0.5
UCECchr163666071Missense_Mutationrs764283922D428G0.45
UCECchr163674345Silentrs146112190P346P0.38
UCECchr163663476Silentrs762072656T552T0.25
UCECchr163663497Missense_MutationnovelK545N0.25
UCECchr163666038Missense_MutationnovelK439T0.4
UCECchr163672757Missense_Mutationrs144436579V370F0.5
UCECchr163672762Missense_Mutationrs375364304R368H0.34
UCECchr163679729Missense_MutationNAS178L0.28
UCECchr163690834Silentrs766135520S80S0.37
UCECchr163674387SilentnovelK332K0.36
UCECchr163686122SilentnovelE115E0.38
UCECchr163658860Missense_Mutationrs147353660A649V0.19
UCECchr163675387Silentrs138639006T275T0.28
UCECchr163674489Missense_MutationnovelI298M0.24
UCECchr163677748Intronnovel0.26
UCECchr163675387Silentrs138639006T275T0.11
UCECchr163676045Missense_Mutationrs376597215R269W0.45
UCECchr163690895Missense_MutationnovelS60N0.12
UCECchr163662020Missense_MutationnovelQ636R0.44
UCECchr163686105Missense_MutationNAS121I0.2
UCECchr163666049SilentnovelE435E0.28
UCECchr163690826Splice_SitenovelX83_splice0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.53330.22898
BLCADEL0.33583.2014e-16
CHOLDEL0.11110.23475

Survival Analysis
CancerP-value Q-value
KIRC0.00087

Kaplan-Meier Survival Analysis

STAD0.044

Kaplan-Meier Survival Analysis

ACC0.014

Kaplan-Meier Survival Analysis

UCS0.029

Kaplan-Meier Survival Analysis

SKCM0.0031

Kaplan-Meier Survival Analysis

PRAD0.0081

Kaplan-Meier Survival Analysis

COAD0.0098

Kaplan-Meier Survival Analysis

BLCA0.019

Kaplan-Meier Survival Analysis

READ0.012

Kaplan-Meier Survival Analysis

LAML0.0074

Kaplan-Meier Survival Analysis

LIHC0.021

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.034

Kaplan-Meier Survival Analysis

UVM0.012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000126602 (Gene tree)
Gene ID
10131
Gene Symbol
TRAP1
Alias
HSP75|HSP90L
Full Name
TNF receptor associated protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
65,959 bases
Position
chr16:3,651,639-3,717,597
Accession
16264
RBP type
non-canonical RBP
Summary
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19940440Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator.Sex Dev2010Kohno Sdoi: 10.1159/000260374
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000571011TRAP1-205480-ENSP0000046054586 (aa)-I3L3L4
ENST00000570403TRAP1-203521-ENSP0000046135437 (aa)-I3L4L7
ENST00000575707TRAP1-213785-ENSP0000045938559 (aa)-I3L253
ENST00000573872TRAP1-208656--- (aa)--
ENST00000246957TRAP1-2012296-ENSP00000246957704 (aa)-Q12931
ENST00000576335TRAP1-216645-ENSP00000459354215 (aa)-I3L239
ENST00000576106TRAP1-215555--- (aa)--
ENST00000574494TRAP1-210547--- (aa)--
ENST00000575671TRAP1-2122309-ENSP00000458166495 (aa)-I3L0K7
ENST00000575854TRAP1-214595--- (aa)--
ENST00000576788TRAP1-217568--- (aa)--
ENST00000571538TRAP1-206587-ENSP0000045824435 (aa)-I3L0P6
ENST00000538171TRAP1-2022052XM_011522345ENSP00000442070651 (aa)XP_011520647Q12931
ENST00000574941TRAP1-211558--- (aa)--
ENST00000571804TRAP1-207781-ENSP0000046161837 (aa)-I3L4L7
ENST00000570514TRAP1-204412--- (aa)--
ENST00000574175TRAP1-209535-ENSP00000459585108 (aa)-I3L2D5
Gene Model
Click here to download ENSG00000126602's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000126602Cholangitis, Sclerosing4E-727992413
ENSG00000126602Homovanillic Acid5E-623319000
ENSG00000126602Hydroxyindoleacetic Acid5E-623319000
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000126602rs6500550163696240TWhite blood cell count27863252[0.016-0.032] unit decrease0.02400567EFO_0004308
ENSG00000126602rs6500550163696240TNeutrophil count27863252[0.017-0.032] unit decrease0.02436507EFO_0004833
ENSG00000126602rs6500550163696240TGranulocyte count27863252[0.015-0.031] unit decrease0.02317921EFO_0007987
ENSG00000126602rs6500550163696240TSum neutrophil eosinophil counts27863252[0.016-0.032] unit decrease0.02403534EFO_0004833|EFO_0004842
ENSG00000126602rs6500550163696240TSum basophil neutrophil counts27863252[0.016-0.031] unit decrease0.02363953EFO_0004833|EFO_0005090
ENSG00000126602rs56340469163696768?White blood cell count30595370EFO_0004308
ENSG00000126602rs111843862163682594TSmoking initiation (ever regular vs never regular) (MTAG)30643251[0.0053-0.0102] unit increase0.00773933EFO_0006527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000126602's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000126602TRAP19460.606WBGene00000915daf-219332.541Caenorhabditis_elegans
ENSG00000126602TRAP110062.857FBgn0026761Trap19352.877Drosophila_melanogaster
ENSG00000126602TRAP19463.636FBgn0001233Hsp838545.813Drosophila_melanogaster
ENSG00000126602TRAP110048.571ENSG00000166598HSP90B19051.163Homo_sapiens
ENSG00000126602TRAP110054.286ENSG00000080824HSP90AA18741.564Homo_sapiens
ENSG00000126602TRAP19346.411ENSG00000096384HSP90AB18546.411Homo_sapiens
ENSG00000126602TRAP110094.286ENSMUSG00000005981Trap110088.244Mus_musculus
ENSG00000126602TRAP110048.571ENSMUSG00000020048Hsp90b19331.956Mus_musculus
ENSG00000126602TRAP19345.320ENSMUSG00000021270Hsp90aa18946.448Mus_musculus
ENSG00000126602TRAP19346.411ENSMUSG00000023944Hsp90ab18658.333Mus_musculus
ENSG00000126602TRAP19445.283YPL240CHSP828546.377Saccharomyces_cerevisiae
ENSG00000126602TRAP19345.411YMR186WHSC828645.411Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005164tumor necrosis factor receptor binding7876093.NASFunction
GO:0005515protein binding17579517.23564345.23747254.29128334.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005739mitochondrion21873635.IBAComponent
GO:0005739mitochondrion17579517.IDAComponent
GO:0005743mitochondrial inner membrane21873635.IBAComponent
GO:0005743mitochondrial inner membrane23564345.IDAComponent
GO:0005758mitochondrial intermembrane space17579517.ISSComponent
GO:0005759mitochondrial matrix23564345.IDAComponent
GO:0009386translational attenuation24113185.IMPProcess
GO:0016020membrane19946888.HDAComponent
GO:0019901protein kinase binding21873635.IBAFunction
GO:0019901protein kinase binding17579517.IPIFunction
GO:0051082unfolded protein binding-IEAFunction
GO:0061077chaperone-mediated protein folding24522549.TASProcess
GO:1901856negative regulation of cellular respiration23564345.IMPProcess
GO:1903427negative regulation of reactive oxygen species biosynthetic process18221368.TASProcess
GO:1903751negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide17579517.ISSProcess
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