EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25338767	Attenuation of enoyl coenzyme A hydratase short chain 1 expression in gastric cancer cells inhibits cell proliferation and migration in vitro.	Cell Mol Biol Lett	2014 Dec	Zhu XS	doi: 10.2478/s11658-014-0213-5
25739098	Attenuation of enoyl coenzyme A hydratase 1 expression in colorectal cancer cells using small interfering RNA inhibits cell proliferation and migration.	Mol Med Rep	2015 Jul	Zhao QM	doi: 10.3892/mmr.2015.3418

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	133366036	Nonsense_Mutation	novel	E227*	0.23
BLCA	chr10	133362829	3'UTR	novel		0.26
BLCA	chr10	133370699	Silent	novel	L49L	0.19
BLCA	chr10	133366940	Missense_Mutation	novel	E190Q	0.35
BRCA	chr10	133366082	Silent	NA	K211K	0.42
BRCA	chr10	133366001	Silent	novel	A238A	0.07
BRCA	chr10	133370018	Missense_Mutation	novel	I100M	0.13
CESC	chr10	133362846	3'UTR	novel		0.25
CESC	chr10	133362768	3'UTR	novel		0.38
COAD	chr10	133364720	Nonsense_Mutation	NA	E249*	0.37
COAD	chr10	133362793	3'UTR	novel		0.21
COAD	chr10	133373281	Missense_Mutation	NA	P18L	0.41
COAD	chr10	133370696	Frame_Shift_Del	novel	*L49Ffs3**	0.1
COAD	chr10	133370660	Silent	rs754145676	C62C	0.22
COAD	chr10	133366977	Missense_Mutation	NA	Q177H	0.22
COAD	chr10	133370734	Missense_Mutation	rs745362960	A38T	0.27
COAD	chr10	133362926	Missense_Mutation	rs575638199	R272Q	0.36
GBM	chr10	133370009	Missense_Mutation	NA	M103I	0.7
GBM	chr10	133362857	3'UTR	novel		0.19
GBM	chr10	133369958	Nonsense_Mutation	novel	W120*	0.46
GBM	chr10	133366043	Missense_Mutation	NA	Q224H	0.17
HNSC	chr10	133368979	Missense_Mutation	rs759771909	Y153C	0.26
KIRC	chr10	133370617	Missense_Mutation	NA	E77K	0.21
LGG	chr10	133362909	Missense_Mutation	novel	A278T	0.34
LIHC	chr10	133365985	Missense_Mutation	NA	V244L	0.18
LIHC	chr10	133366962	Silent	novel	A182A	0.34
LUAD	chr10	133370655	Missense_Mutation	novel	G64D	0.17
LUAD	chr10	133369963	Missense_Mutation	novel	H119Y	0.29
LUAD	chr10	133366994	Splice_Site	novel	X172_splice	0.22
LUAD	chr10	133364669	Missense_Mutation	rs770614061	T266A	0.28
LUAD	chr10	133370698	Missense_Mutation	NA	I50F	0.27
LUSC	chr10	133366026	Missense_Mutation	NA	A230V	0.15
LUSC	chr10	133370033	Splice_Site	novel	X96_splice	0.22
OV	chr10	133366004	Silent	novel	V237V	0.07
OV	chr10	133370016	Missense_Mutation	novel	K101M	0.65
OV	chr10	133370728	Missense_Mutation	novel	K40E	0.09
OV	chr10	133366995	Splice_Site	NA	X172_splice	0.33
PRAD	chr10	133366919	Missense_Mutation	rs751581356	R197W	0.1
READ	chr10	133362830	3'UTR	novel		0.38
READ	chr10	133366029	Frame_Shift_Ins	NA	*I229Nfs6**	0.47
SKCM	chr10	133368942	Silent	novel	I165I	0.33
SKCM	chr10	133370595	Missense_Mutation	NA	A84V	0.73
SKCM	chr10	133364668	Missense_Mutation	NA	T266I	0.32
SKCM	chr10	133366046	Silent	NA	I223I	0.18
SKCM	chr10	133368969	Silent	NA	E156E	0.45
SKCM	chr10	133370598	Missense_Mutation	rs749433804	G83E	0.34
STAD	chr10	133370722	Missense_Mutation	novel	G42W	0.5
STAD	chr10	133366064	Silent	novel	T217T	0.42
STAD	chr10	133366027	Missense_Mutation	NA	A230T	0.35
STAD	chr10	133366038	Missense_Mutation	novel	A226V	0.2
STAD	chr10	133366033	Missense_Mutation	novel	K228Q	0.07
THCA	chr10	133366088	Silent	novel	V209V	0.41
UCEC	chr10	133364679	Silent	rs776186632	L262L	0.27
UCEC	chr10	133369995	Missense_Mutation	NA	F108C	0.38
UCEC	chr10	133370617	Missense_Mutation	NA	E77K	0.21
UCEC	chr10	133362915	Missense_Mutation	NA	M276V	0.36
UCEC	chr10	133370734	Missense_Mutation	rs745362960	A38T	0.37
UCEC	chr10	133370692	Silent	novel	L52L	0.06
UCEC	chr10	133366002	Missense_Mutation	rs200584793	A238V	0.24
UCEC	chr10	133369925	Silent	rs138522349	I131I	0.34
UCEC	chr10	133370579	Silent	rs551624552	G89G	0.37
UCEC	chr10	133369905	Missense_Mutation	NA	A138V	0.37
UCEC	chr10	133362825	3'UTR	novel		0.55
UCEC	chr10	133369017	Silent	rs751113264	G140G	0.45
UCEC	chr10	133370724	Frame_Shift_Ins	rs751306953	*R41Kfs5**	0.35
UCEC	chr10	133364721	Silent	novel	F248F	0.24
UCEC	chr10	133370660	Silent	rs754145676	C62C	0.37
UCEC	chr10	133362738	3'UTR	rs188884786		0.33
UCEC	chr10	133366951	Missense_Mutation	rs200293355	S186L	0.3
UCEC	chr10	133366050	Missense_Mutation	novel	A222V	0.4
UCEC	chr10	133364702	Nonsense_Mutation	novel	G255*	0.14
UCEC	chr10	133366002	Missense_Mutation	rs200584793	A238V	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	0.19593
BRCA	DEL	0.2343	9.4498e-14
CHOL	DEL	0.1944	0.048655
COAD	DEL	0.1663	9.4741e-07
LGG	DEL	0.2651	4.3789e-20
LIHC	DEL	0.2459	5.7505e-06
LUAD	DEL	0.188	0.032471
PAAD	DEL	0.1141	0.169
READ	DEL	0.2	0.014135
TGCT	DEL	0.44	9.1106e-08
THYM	DEL	0.0325	0.10563
UCS	DEL	0.2679	0.1218

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0043	Kaplan-Meier Survival Analysis
STAD	0.031	Kaplan-Meier Survival Analysis
UCS	0.012	Kaplan-Meier Survival Analysis
SKCM	0.041	Kaplan-Meier Survival Analysis
TGCT	0.03	Kaplan-Meier Survival Analysis
KIRP	0.0056	Kaplan-Meier Survival Analysis
BLCA	0.044	Kaplan-Meier Survival Analysis
CESC	0.039	Kaplan-Meier Survival Analysis
READ	0.0083	Kaplan-Meier Survival Analysis
LAML	0.00013	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
UVM	0.0039	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000127884 (Gene tree)
Gene ID: 1892
Gene Symbol: ECHS1
Alias: SCEH
Full Name: enoyl-CoA hydratase, short chain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 11,210 bases
Position: chr10:133,362,480-133,373,689
Accession: 3151
RBP type: non-canonical RBP
Summary: The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368547	ECHS1-201	1617	-	ENSP00000357535	290 (aa)	-	P30084

Gene Model

Click here to download ENSG00000127884's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00062	Fatty acid elongation	KEGG
hsa00071	Fatty acid degradation	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa00310	Lysine degradation	KEGG
hsa00380	Tryptophan metabolism	KEGG
hsa00410	beta-Alanine metabolism	KEGG
hsa00640	Propanoate metabolism	KEGG
hsa00650	Butanoate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01212	Fatty acid metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000127884	Longevity	3E-10	25918517

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000127884	rs7894051	10	133370917	?	Lifespan	25918517	[NR] unit decrease	3.525	EFO_0004300

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000127884's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000127884	ECHS1	89	61.479	WBGene00001155	ech-6	89	61.479	Caenorhabditis_elegans
ENSG00000127884	ECHS1	95	57.091	FBgn0033879	CG6543	93	57.091	Drosophila_melanogaster
ENSG00000127884	ECHS1	100	87.586	ENSMUSG00000025465	Echs1	100	87.586	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004300	enoyl-CoA hydratase activity	21873635.	IBA	Function
GO:0004300	enoyl-CoA hydratase activity	26251176.	IDA	Function
GO:0005515	protein binding	14557246.23416296.24510904.24947832.	IPI	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005739	mitochondrion	16130169.	TAS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006635	fatty acid beta-oxidation	21873635.	IBA	Process
GO:0006635	fatty acid beta-oxidation	26251176.	IDA	Process
GO:0006635	fatty acid beta-oxidation	-	IEA	Process
GO:0006635	fatty acid beta-oxidation	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.