EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr15	24976961	Missense_Mutation	novel	V118L	0.43
ACC	chr15	24954967	5'UTR	novel		0.15
BLCA	chr15	24978255	Missense_Mutation	novel	A208S	0.52
BLCA	chr15	24977871	Missense_Mutation	NA	R172W	0.17
BLCA	chr15	24978271	Missense_Mutation	NA	I213T	0.36
BLCA	chr15	24955030	5'UTR	novel		0.2
BLCA	chr15	24982104	3'Flank	novel		0.06
BLCA	chr15	24982055	3'Flank	rs750523838		0.42
BLCA	chr15	24955029	5'UTR	novel		0.4
BRCA	chr15	24974841	Intron	novel		0.2
BRCA	chr15	24976367	Missense_Mutation	NA	R73L	0.54
BRCA	chr15	24974918	Intron	novel		0.17
BRCA	chr15	24974681	Intron	novel		0.33
BRCA	chr15	24976904	Nonsense_Mutation	NA	G99*	0.37
BRCA	chr15	24978301	Missense_Mutation	NA	P223L	0.2
CESC	chr15	24982074	3'Flank	novel		0.44
CESC	chr15	24968039	5'UTR	novel		0.13
CESC	chr15	24980007	3'Flank	novel		0.31
CESC	chr15	24955045	5'UTR	rs148206963		0.48
CESC	chr15	24978285	Missense_Mutation	NA	P218S	0.42
COAD	chr15	24974367	Intron	novel		0.13
COAD	chr15	24978428	Missense_Mutation	NA	R236H	0.31
COAD	chr15	24975395	Missense_Mutation	novel	D14G	0.11	LSM
COAD	chr15	24982362	3'Flank	novel		0.46
COAD	chr15	24976986	Missense_Mutation	NA	G126V	0.32
COAD	chr15	24978281	Silent	rs746441330	P216P	0.43
COAD	chr15	24977827	Missense_Mutation	rs775190561	A157V	0.29
COAD	chr15	24974718	Intron	NA		0.5
COAD	chr15	24975509	Missense_Mutation	NA	K52T	0.22	LSM
COAD	chr15	24975377	Missense_Mutation	NA	K8R	0.28
COAD	chr15	24978287	Silent	NA	P218P	0.41
COAD	chr15	24976405	Frame_Shift_Del	NA	*D89Ifs53**	0.42
COAD	chr15	24978297	Frame_Shift_Del	NA	*P223Lfs39**	0.42
COAD	chr15	24982220	3'Flank	novel		0.19
COAD	chr15	24977848	Missense_Mutation	novel	A164V	0.24
COAD	chr15	24978261	Missense_Mutation	NA	G210W	0.17
DLBC	chr15	24977824	Missense_Mutation	rs372352489	A156V	0.4
ESCA	chr15	24976342	Missense_Mutation	novel	R65W	0.12
ESCA	chr15	24974405	5'UTR	novel		0.27
ESCA	chr15	24975509	Missense_Mutation	NA	K52T	0.2	LSM
ESCA	chr15	24978427	Missense_Mutation	NA	R236C	0.24
ESCA	chr15	24974414	5'UTR	rs767553112		0.33
ESCA	chr15	24982168	3'Flank	novel		0.19
ESCA	chr15	24974414	5'UTR	rs767553112		0.32
ESCA	chr15	24978437	Missense_Mutation	novel	R239T	0.19
ESCA	chr15	24974803	Intron	novel		0.22
ESCA	chr15	24977885	Silent	novel	P176P	0.19
ESCA	chr15	24978543	3'UTR	novel		0.67
GBM	chr15	24955006	5'UTR	rs375357277		0.11
GBM	chr15	24978458	3'UTR	novel		0.07
GBM	chr15	24978581	3'UTR	novel		0.44
GBM	chr15	24977780	Splice_Region	novel	V141V	0.07
GBM	chr15	24955019	5'UTR	rs199920294		0.61
GBM	chr15	24977002	Silent	novel	V131V	0.27
HNSC	chr15	24978293	Missense_Mutation	novel	M220I	0.05
HNSC	chr15	24976409	Missense_Mutation	NA	P87L	0.2
HNSC	chr15	24978466	3'UTR	novel		0.15
HNSC	chr15	24979989	3'Flank	novel		0.17
HNSC	chr15	24977012	Frame_Shift_Del	novel	*G136Dfs6**	0.22
HNSC	chr15	24976367	Missense_Mutation	rs755610165	R73H	0.08
HNSC	chr15	24978220	Missense_Mutation	novel	R196T	0.09
HNSC	chr15	24976904	Nonsense_Mutation	NA	G99*	0.16
HNSC	chr15	24976905	Missense_Mutation	novel	G99V	0.18
HNSC	chr15	24982015	3'Flank	novel		0.41
HNSC	chr15	24978410	Missense_Mutation	novel	P230L	0.22
HNSC	chr15	24974339	Intron	novel		0.19
KIRC	chr15	24976998	Missense_Mutation	NA	P130R	0.29
KIRC	chr15	24975421	Missense_Mutation	NA	D23Y	0.31	LSM
KIRC	chr15	24981890	3'Flank	novel		0.05
KIRC	chr15	24978507	3'UTR	novel		0.2
LGG	chr15	24978449	3'UTR	novel		0.36
LGG	chr15	24979961	3'Flank	novel		0.54
LIHC	chr15	24977827	Missense_Mutation	NA	A157E	0.36
LIHC	chr15	24976356	Silent	NA	L69L	0.05
LIHC	chr15	24974449	5'UTR	novel		0.26
LIHC	chr15	24976887	Missense_Mutation	novel	A93D	0.1
LUAD	chr15	24977002	Silent	novel	V131V	0.15
LUAD	chr15	24976408	Missense_Mutation	novel	P87S	0.17
LUAD	chr15	24976901	Missense_Mutation	novel	A98S	0.14
LUAD	chr15	24976351	Missense_Mutation	NA	G68C	0.36
LUAD	chr15	24978190	Splice_Region	novel		0.21
LUAD	chr15	24954967	5'UTR	novel		0.42
LUAD	chr15	24978252	Missense_Mutation	novel	P207T	0.16
LUAD	chr15	24978427	Missense_Mutation	novel	R236S	0.06
LUAD	chr15	24978250	Missense_Mutation	novel	P206R	0.15
LUAD	chr15	24976905	Missense_Mutation	novel	G99V	0.17
LUAD	chr15	24974442	5'UTR	novel		0.2
LUAD	chr15	24980026	3'Flank	NA		0.15
LUAD	chr15	24980027	3'Flank	novel		0.15
LUAD	chr15	24955046	5'UTR	novel		0.35
LUAD	chr15	24977024	Missense_Mutation	NA	Q139K	0.39
LUAD	chr15	24955012	5'UTR	rs749365354		0.29
LUAD	chr15	24974650	Intron	novel		0.43
LUAD	chr15	24980025	3'Flank	NA		0.38
LUAD	chr15	24976330	Missense_Mutation	NA	R61C	0.21
LUAD	chr15	24968071	5'UTR	novel		0.2
LUAD	chr15	24976915	Silent	NA	G102G	0.24
LUAD	chr15	24976995	Missense_Mutation	novel	G129V	0.34
LUAD	chr15	24976886	Missense_Mutation	rs200334709	A93S	0.16
LUAD	chr15	24955004	5'UTR	novel		0.09
LUAD	chr15	24955005	5'UTR	novel		0.09
LUAD	chr15	24976968	Missense_Mutation	novel	I120T	0.23
LUAD	chr15	24976343	Missense_Mutation	novel	R65L	0.21
LUSC	chr15	24976907	Missense_Mutation	NA	A100T	0.32
LUSC	chr15	24974434	5'UTR	novel		0.39
LUSC	chr15	24981981	3'Flank	novel		0.19
LUSC	chr15	24977806	Missense_Mutation	novel	V150E	0.42
LUSC	chr15	24981805	3'Flank	novel		0.5
LUSC	chr15	24974381	Splice_Region	novel		0.77
LUSC	chr15	24978244	Missense_Mutation	NA	G204V	0.16
LUSC	chr15	24981984	3'Flank	novel		0.28
LUSC	chr15	24982150	3'Flank	novel		0.58
LUSC	chr15	24976982	Missense_Mutation	NA	A125S	0.17
LUSC	chr15	24981833	3'Flank	novel		0.41
LUSC	chr15	24974400	5'UTR	novel		0.18
LUSC	chr15	24977865	Missense_Mutation	novel	P170T	0.19
LUSC	chr15	24968048	5'UTR	novel		0.11
LUSC	chr15	24974411	5'UTR	novel		0.11
LUSC	chr15	24978275	Silent	NA	G214G	0.24
LUSC	chr15	24978444	Nonstop_Mutation	novel	241Yext17	0.2
LUSC	chr15	24977871	Silent	novel	R172R	0.26
LUSC	chr15	24978439	Missense_Mutation	novel	P240T	0.07
LUSC	chr15	24976909	Silent	novel	A100A	0.27
LUSC	chr15	24974393	5'UTR	novel		0.48
LUSC	chr15	24955048	5'UTR	rs749134956		0.63
LUSC	chr15	24976366	Missense_Mutation	novel	R73C	0.13
LUSC	chr15	24978474	3'UTR	novel		0.38
LUSC	chr15	24975425	Missense_Mutation	NA	G24V	0.16	LSM
LUSC	chr15	24981838	3'Flank	novel		0.21
LUSC	chr15	24975483	Nonsense_Mutation	novel	C43*	0.35	LSM
LUSC	chr15	24974436	5'UTR	novel		0.3
OV	chr15	24962210	Splice_Site	novel		0.12
OV	chr15	24981970	3'Flank	novel		0.27
OV	chr15	24978282	Missense_Mutation	NA	P217A	0.15
OV	chr15	24980077	3'Flank	novel		0.12
OV	chr15	24974298	Intron	novel		0.32
OV	chr15	24976977	Missense_Mutation	NA	A123G	0.39
PAAD	chr15	24978266	Silent	rs372752818	T211T	0.27
PAAD	chr15	24976330	Missense_Mutation	NA	R61C	0.13
PAAD	chr15	24977847	Missense_Mutation	rs772663663	A164S	0.22
PRAD	chr15	24976410	Silent	rs200650114	P87P	0.45
PRAD	chr15	24978297	Frame_Shift_Del	NA	*P223Lfs39**	0.06
PRAD	chr15	24955045	5'UTR	rs148206963		0.17
READ	chr15	24975394	Missense_Mutation	novel	D14N	0.07	LSM
READ	chr15	24974310	Intron	novel		0.38
READ	chr15	24982129	3'Flank	novel		0.53
READ	chr15	24982313	3'Flank	novel		0.37
SKCM	chr15	24982144	3'Flank	novel		0.3
SKCM	chr15	24976370	Missense_Mutation	novel	G74E	0.16
SKCM	chr15	24980035	3'Flank	novel		0.55
SKCM	chr15	24981876	3'Flank	novel		0.23
SKCM	chr15	24975414	Silent	NA	I20I	0.34
SKCM	chr15	24977913	Missense_Mutation	rs71461576	P186S	0.74
SKCM	chr15	24978286	Missense_Mutation	NA	P218L	0.35
SKCM	chr15	24981941	3'Flank	novel		0.37
SKCM	chr15	24982095	3'Flank	rs759814409		0.54
SKCM	chr15	24982030	3'Flank	NA		0.48
SKCM	chr15	24978249	Missense_Mutation	novel	P206S	0.27
SKCM	chr15	24979957	3'Flank	novel		0.3
SKCM	chr15	24968058	5'UTR	novel		0.49
SKCM	chr15	24978412	Missense_Mutation	NA	P231T	0.24
SKCM	chr15	24982030	3'Flank	NA		0.13
SKCM	chr15	24982068	3'Flank	novel		0.33
SKCM	chr15	24978213	Missense_Mutation	NA	G194S	0.27
SKCM	chr15	24980042	3'Flank	novel		0.36
SKCM	chr15	24976309	Missense_Mutation	novel	K54E	0.54
SKCM	chr15	24976970	Missense_Mutation	NA	P121S	0.39
SKCM	chr15	24981951	3'Flank	novel		0.05
SKCM	chr15	24974302	Intron	novel		0.26
SKCM	chr15	24982095	3'Flank	rs759814409		0.28
SKCM	chr15	24981822	3'Flank	novel		0.15
SKCM	chr15	24982069	3'Flank	novel		0.27
SKCM	chr15	24981968	3'Flank	novel		0.09
SKCM	chr15	24962111	Splice_Region	NA		0.25
SKCM	chr15	24978416	Missense_Mutation	NA	P232L	0.2
SKCM	chr15	24978496	3'UTR	novel		0.17
SKCM	chr15	24982095	3'Flank	rs759814409		0.53
SKCM	chr15	24955032	5'UTR	novel		0.17
SKCM	chr15	24982030	3'Flank	NA		0.54
SKCM	chr15	24978527	3'UTR	novel		0.28
SKCM	chr15	24982095	3'Flank	rs759814409		0.57
SKCM	chr15	24977013	Missense_Mutation	NA	G135E	0.29
SKCM	chr15	24978475	3'UTR	novel		0.43
SKCM	chr15	24981896	3'Flank	novel		0.15
STAD	chr15	24976906	Silent	NA	G99G	0.12
STAD	chr15	24974440	5'UTR	novel		0.25
STAD	chr15	24974414	5'UTR	rs767553112		0.12
STAD	chr15	24975481	Missense_Mutation	NA	C43R	0.26	LSM
STAD	chr15	24982220	3'Flank	NA		0.32
STAD	chr15	24982049	3'Flank	novel		0.38
STAD	chr15	24976935	Missense_Mutation	NA	A109E	0.22
STAD	chr15	24974414	5'UTR	rs767553112		0.22
STAD	chr15	24976949	Missense_Mutation	rs370688371	V114L	0.31
STAD	chr15	24981783	3'Flank	rs767993170		0.56
STAD	chr15	24975509	Missense_Mutation	NA	K52T	0.05	LSM
STAD	chr15	24978427	Missense_Mutation	NA	R236C	0.07
STAD	chr15	24982116	3'Flank	novel		0.07
STAD	chr15	24982209	3'Flank	novel		0.25
STAD	chr15	24978230	Missense_Mutation	novel	M199I	0.26
STAD	chr15	24982220	3'Flank	NA		0.43
STAD	chr15	24982011	3'Flank	novel		0.13
STAD	chr15	24978525	3'UTR	novel		0.11
STAD	chr15	24975509	Missense_Mutation	NA	K52T	0.48	LSM
STAD	chr15	24981943	3'Flank	novel		0.06
STAD	chr15	24978532	3'UTR	novel		0.23
STAD	chr15	24974414	5'UTR	rs767553112		0.21
STAD	chr15	24976984	Silent	NA	A125A	0.39
STAD	chr15	24977805	Missense_Mutation	NA	V150I	0.32
STAD	chr15	24978271	Missense_Mutation	NA	I213T	0.47
STAD	chr15	24982079	3'Flank	novel		0.25
STAD	chr15	24982220	3'Flank	NA		0.32
STAD	chr15	24977834	Silent	novel	A159A	0.21
STAD	chr15	24982220	3'Flank	NA		0.43
STAD	chr15	24975509	Missense_Mutation	NA	K52T	0.14	LSM
STAD	chr15	24976316	Missense_Mutation	rs571239725	A56V	0.18
STAD	chr15	24982049	3'Flank	novel		0.08
STAD	chr15	24977827	Missense_Mutation	rs775190561	A157V	0.38
STAD	chr15	24978470	3'UTR	novel		0.23
STAD	chr15	24954932	5'Flank	novel		0.67
STAD	chr15	24982220	3'Flank	NA		0.56
STAD	chr15	24954927	5'Flank	novel		0.33
UCEC	chr15	24978545	3'UTR	novel		0.37
UCEC	chr15	24978248	Silent	novel	L205L	0.55
UCEC	chr15	24982220	3'Flank	NA		0.52
UCEC	chr15	24978266	Silent	rs372752818	T211T	0.52
UCEC	chr15	24975442	Missense_Mutation	novel	T30A	0.36	LSM
UCEC	chr15	24978538	3'UTR	novel		0.47
UCEC	chr15	24975468	Missense_Mutation	NA	M38I	0.16	LSM
UCEC	chr15	24977886	Missense_Mutation	NA	P177S	0.15
UCEC	chr15	24978265	Missense_Mutation	rs764893207	T211M	0.2
UCEC	chr15	24968083	Splice_Site	rs368905564		0.35
UCEC	chr15	24955047	5'UTR	rs140138645		0.11
UCEC	chr15	24975428	Missense_Mutation	rs749853771	R25Q	0.08	LSM
UCEC	chr15	24977842	Missense_Mutation	novel	A162D	0.41
UCEC	chr15	24980059	3'Flank	novel		0.12
UCEC	chr15	24955045	5'UTR	rs148206963		0.35
UCEC	chr15	24976316	Missense_Mutation	rs571239725	A56V	0.37
UCEC	chr15	24975371	Missense_Mutation	novel	S6N	0.4
UCEC	chr15	24977808	Missense_Mutation	novel	A151S	0.14
UCEC	chr15	24976367	Missense_Mutation	rs755610165	R73H	0.47
UCEC	chr15	24955003	5'UTR	rs370477576		0.19
UCEC	chr15	24975411	Silent	NA	C19C	0.28
UCEC	chr15	24978279	Missense_Mutation	NA	P216S	0.39
UCEC	chr15	24977031	Splice_Site	novel	X140_splice	0.21
UCEC	chr15	24954947	5'UTR	rs529153586		0.4
UCEC	chr15	24978497	3'UTR	novel		0.29
UCEC	chr15	24978281	Silent	rs746441330	P216P	0.15
UCEC	chr15	24974811	Intron	novel		0.5
UCEC	chr15	24974734	Intron	novel		0.18
UCEC	chr15	24975468	Missense_Mutation	NA	M38I	0.35	LSM
UCEC	chr15	24978295	Missense_Mutation	novel	R221I	0.39
UCEC	chr15	24976954	Silent	novel	P115P	0.36
UCEC	chr15	24978303	Missense_Mutation	NA	P224S	0.06
UCEC	chr15	24976990	Missense_Mutation	novel	L127F	0.42
UCEC	chr15	24976922	Missense_Mutation	NA	G105W	0.07
UCEC	chr15	24975372	Silent	novel	S6S	0.17
UCEC	chr15	24981857	3'Flank	rs531371876		0.26
UCEC	chr15	24982096	3'Flank	rs772339470		0.23
UCEC	chr15	24954932	5'Flank	novel		0.52
UCEC	chr15	24978302	Frame_Shift_Del	novel	*P224Hfs38**	0.4
UCEC	chr15	24954932	5'Flank	novel		0.35
UCEC	chr15	24982348	3'Flank	novel		0.36
UCEC	chr15	24974405	5'UTR	novel		0.38
UCEC	chr15	24978220	Missense_Mutation	novel	R196K	0.34
UCEC	chr15	24977880	Missense_Mutation	novel	P175S	0.48
UCEC	chr15	24976323	Missense_Mutation	novel	Q58H	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2111	0.079424
BLCA	DEL	0.2892	0.00034787
COAD	DEL	0.3592	1.0065e-06
ESCA	DEL	0.2337	0.035837
HNSC	DEL	0.1552	0.11567
KICH	AMP	0.2576	0.21756
KIRP	DEL	0.1042	0.2062
LUAD	DEL	0.3857	6.8561e-07
LUSC	DEL	0.2415	5.9764e-05
PAAD	DEL	0.1033	0.13216
PRAD	AMP	0.0244	0.015423
READ	DEL	0.4182	0.025797
SARC	DEL	0.1556	0.18974
STAD	DEL	0.1927	3.7853e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0019	Kaplan-Meier Survival Analysis
STAD	0.038	Kaplan-Meier Survival Analysis
MESO	0.014	Kaplan-Meier Survival Analysis
UCS	0.0047	Kaplan-Meier Survival Analysis
SKCM	0.0069	Kaplan-Meier Survival Analysis
KIRP	0.0063	Kaplan-Meier Survival Analysis
PAAD	0.0089	Kaplan-Meier Survival Analysis
CESC	0.0077	Kaplan-Meier Survival Analysis
LUAD	0.0015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000128739 (Gene tree)
Gene ID: 6638
Gene Symbol: SNRPN
Alias: SMN|SM-D|HCERN3|SNRNP-N|SNURF-SNRPN|RT-LI|PWCR
Full Name: small nuclear ribonucleoprotein polypeptide N
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 155,087 bases
Position: chr15:24,823,637-24,978,723
Accession: 11164
RBP type: canonical RBP
Summary: This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000463510	LSM	PF01423.22	1.3e-19	1	1
ENSP00000306223	LSM	PF01423.22	2.7e-19	1	1
ENSP00000375105	LSM	PF01423.22	2.7e-19	1	1
ENSP00000382969	LSM	PF01423.22	2.7e-19	1	1
ENSP00000382972	LSM	PF01423.22	2.7e-19	1	1
ENSP00000463458	LSM	PF01423.22	2.7e-19	1	1
ENSP00000494831	LSM	PF01423.22	2.7e-19	1	1
ENSP00000495345	LSM	PF01423.22	2.7e-19	1	1
ENSP00000452342	LSM	PF01423.22	2.7e-19	1	1
ENSP00000462211	LSM	PF01423.22	5.5e-14	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28387446	Polymorphisms in the SNRPN gene are associated with obesity susceptibility in a Spanish population.	J Gene Med	2017 May	Albuquerque D	doi: 10.1002/jgm.2956.
8502240	C-reactive protein (CRP) binding to the Sm-D protein of snRNPS. Identification of a short polypeptide binding region.	Mol Immunol	1993 Jun	Jewell WS	-
24311566	Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis.	Nucleic Acids Res	2014 Feb	Ishikawa H	doi: 10.1093/nar/gkt1271

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000579070	SNRPN-209	871	-	ENSP00000463510	169 (aa)	-	J3QLE5
ENST00000400097	SNRPN-203	1605	-	ENSP00000382969	240 (aa)	-	P63162
ENST00000577565	SNRPN-208	1298	-	ENSP00000463458	240 (aa)	-	P63162
ENST00000400098	SNRPN-204	525	-	-	- (aa)	-	-
ENST00000390687	SNRPN-202	1528	-	ENSP00000375105	240 (aa)	-	P63162
ENST00000584968	SNRPN-210	908	-	ENSP00000462211	59 (aa)	-	J3KRY3
ENST00000645002	SNRPN-212	1940	-	ENSP00000494831	240 (aa)	-	P63162
ENST00000346403	SNRPN-201	1304	-	ENSP00000306223	240 (aa)	-	P63162
ENST00000400100	SNRPN-205	1751	-	ENSP00000382972	240 (aa)	-	P63162
ENST00000553597	SNRPN-206	849	-	-	- (aa)	-	-
ENST00000642807	SNRPN-211	1835	-	ENSP00000495345	240 (aa)	-	P63162
ENST00000554227	SNRPN-207	1763	-	ENSP00000452342	244 (aa)	-	P63162

Gene Model

Click here to download ENSG00000128739's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000128739	Respiratory Function Tests	1.36266882142553E-6	17903307
ENSG00000128739	Stroke	1.0883615E-004	-
ENSG00000128739	Glomerular Filtration Rate	5.9744733E-005	-
ENSG00000128739	Periodontitis	4E-8	26962152
ENSG00000128739	Tooth	4E-8	26962152
ENSG00000128739	Plaque, Atherosclerotic	5E-6	28282560
ENSG00000128739	Hormones	2E-6	23251661
ENSG00000128739	Respiratory Function Tests	1E-6	17903307

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000128739	rs904310	15	24857294	?	Periodontal disease-related phenotypes	26962152	[0.25-0.53] unit increase	0.39	EFO_0000649\|EFO_0007780
ENSG00000128739	rs2030062	15	24888839	G	Obesity-related traits	23251661	[NR] pM increase	0.03	EFO_0004730
ENSG00000128739	rs12592731	15	24925023	?	Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)	26148204			EFO_0009279\|EFO_0000764\|EFO_0007934
ENSG00000128739	rs11634944	15	24937946	C	Interleukin-8 levels	27989323	[0.072-0.171] SD units increase	0.1214	EFO_0004811
ENSG00000128739	rs34318108	15	24853480	A	Carotid plaque burden	28282560	[0.064-0.161] unit decrease	0.11261877	EFO_0006501
ENSG00000128739	rs3867498	15	24833640	?	Pulmonary function	17903307			EFO_0003892

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128739's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000128739	SNRPN	100	96.450	ENSG00000125835	SNRPB	96	92.760

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000128739	SNRPN	99	100.000	ENSAMEG00000007034	SNRPN	98	99.583	Ailuropoda_melanoleuca
ENSG00000128739	SNRPN	100	100.000	ENSANAG00000034241	SNRPN	100	100.000	Aotus_nancymaae
ENSG00000128739	SNRPN	100	100.000	ENSBTAG00000008251	SNRPN	100	98.750	Bos_taurus
ENSG00000128739	SNRPN	100	100.000	ENSCJAG00000003759	-	100	100.000	Callithrix_jacchus
ENSG00000128739	SNRPN	100	100.000	ENSCJAG00000042622	-	95	99.561	Callithrix_jacchus
ENSG00000128739	SNRPN	100	100.000	ENSCAFG00000010127	SNRPN	100	99.583	Canis_familiaris
ENSG00000128739	SNRPN	100	100.000	ENSCAFG00020024075	SNRPN	100	99.583	Canis_lupus_dingo
ENSG00000128739	SNRPN	100	100.000	ENSCHIG00000017477	SNRPN	100	98.750	Capra_hircus
ENSG00000128739	SNRPN	100	100.000	ENSTSYG00000005248	SNRPN	100	100.000	Carlito_syrichta
ENSG00000128739	SNRPN	100	100.000	ENSCAPG00000003047	SNRPN	100	100.000	Cavia_aperea
ENSG00000128739	SNRPN	100	100.000	ENSCPOG00000020270	SNRPN	100	100.000	Cavia_porcellus
ENSG00000128739	SNRPN	100	100.000	ENSCCAG00000024231	SNRPN	100	100.000	Cebus_capucinus
ENSG00000128739	SNRPN	100	100.000	ENSCATG00000032518	SNRPN	100	100.000	Cercocebus_atys
ENSG00000128739	SNRPN	100	100.000	ENSCLAG00000011376	SNRPN	100	100.000	Chinchilla_lanigera
ENSG00000128739	SNRPN	100	100.000	ENSCSAG00000006406	SNRPN	100	100.000	Chlorocebus_sabaeus
ENSG00000128739	SNRPN	98	98.718	ENSCHOG00000001846	SNRPN	88	98.718	Choloepus_hoffmanni
ENSG00000128739	SNRPN	100	100.000	ENSCANG00000041156	SNRPN	100	100.000	Colobus_angolensis_palliatus
ENSG00000128739	SNRPN	100	100.000	ENSCGRG00001004136	Snrpn	100	99.583	Cricetulus_griseus_chok1gshd
ENSG00000128739	SNRPN	100	100.000	ENSCGRG00000001621	Snrpn	100	99.167	Cricetulus_griseus_crigri
ENSG00000128739	SNRPN	100	96.610	ENSCVAG00000014193	SNRPN	70	92.899	Cyprinodon_variegatus
ENSG00000128739	SNRPN	99	99.405	ENSDNOG00000037060	SNRPN	100	98.361	Dasypus_novemcinctus
ENSG00000128739	SNRPN	100	100.000	ENSDORG00000004527	Snrpn	100	99.583	Dipodomys_ordii
ENSG00000128739	SNRPN	100	100.000	ENSEASG00005017871	SNRPN	100	99.583	Equus_asinus_asinus
ENSG00000128739	SNRPN	100	100.000	ENSECAG00000018148	SNRPN	100	99.583	Equus_caballus
ENSG00000128739	SNRPN	99	99.405	ENSEEUG00000007440	-	100	98.745	Erinaceus_europaeus
ENSG00000128739	SNRPN	100	100.000	ENSFCAG00000022298	-	100	99.583	Felis_catus
ENSG00000128739	SNRPN	83	90.000	ENSFDAG00000010528	-	86	85.792	Fukomys_damarensis
ENSG00000128739	SNRPN	100	100.000	ENSFDAG00000016578	-	100	99.583	Fukomys_damarensis
ENSG00000128739	SNRPN	100	96.610	ENSGMOG00000018161	SNRPN	74	76.331	Gadus_morhua
ENSG00000128739	SNRPN	83	85.714	ENSGGOG00000024469	-	69	83.942	Gorilla_gorilla
ENSG00000128739	SNRPN	100	100.000	ENSGGOG00000003988	SNRPN	100	100.000	Gorilla_gorilla
ENSG00000128739	SNRPN	100	94.915	ENSHGLG00000019812	-	89	91.080	Heterocephalus_glaber_female
ENSG00000128739	SNRPN	100	88.136	ENSHGLG00000020936	-	88	79.812	Heterocephalus_glaber_female
ENSG00000128739	SNRPN	100	93.220	ENSHGLG00000002327	-	88	84.977	Heterocephalus_glaber_female
ENSG00000128739	SNRPN	100	100.000	ENSHGLG00000011924	SNRPN	100	100.000	Heterocephalus_glaber_female
ENSG00000128739	SNRPN	100	94.915	ENSHGLG00100021056	-	89	91.080	Heterocephalus_glaber_male
ENSG00000128739	SNRPN	100	100.000	ENSHGLG00100016559	SNRPN	100	100.000	Heterocephalus_glaber_male
ENSG00000128739	SNRPN	100	94.915	ENSHGLG00100004881	-	88	83.099	Heterocephalus_glaber_male
ENSG00000128739	SNRPN	100	100.000	ENSSTOG00000001339	SNRPN	100	100.000	Ictidomys_tridecemlineatus
ENSG00000128739	SNRPN	99	100.000	ENSLAFG00000009458	SNRPN	100	99.583	Loxodonta_africana
ENSG00000128739	SNRPN	100	100.000	ENSMFAG00000042235	SNRPN	100	100.000	Macaca_fascicularis
ENSG00000128739	SNRPN	100	100.000	ENSMMUG00000023139	SNURF	100	100.000	Macaca_mulatta
ENSG00000128739	SNRPN	100	100.000	ENSMNEG00000031291	SNRPN	100	100.000	Macaca_nemestrina
ENSG00000128739	SNRPN	100	100.000	ENSMLEG00000038837	SNRPN	100	100.000	Mandrillus_leucophaeus
ENSG00000128739	SNRPN	99	89.222	ENSMGAG00000008696	SNRPN	92	85.909	Meleagris_gallopavo
ENSG00000128739	SNRPN	100	100.000	ENSMAUG00000000051	Snrpn	100	100.000	Mesocricetus_auratus
ENSG00000128739	SNRPN	100	100.000	ENSMICG00000042356	SNRPN	100	100.000	Microcebus_murinus
ENSG00000128739	SNRPN	100	100.000	ENSMOCG00000015350	Snrpn	100	100.000	Microtus_ochrogaster
ENSG00000128739	SNRPN	100	100.000	ENSMODG00000013926	-	92	94.118	Monodelphis_domestica
ENSG00000128739	SNRPN	100	100.000	MGP_CAROLIEiJ_G0029815	Snrpn	100	100.000	Mus_caroli
ENSG00000128739	SNRPN	100	100.000	ENSMUSG00000102252	Snrpn	100	100.000	Mus_musculus
ENSG00000128739	SNRPN	100	100.000	MGP_PahariEiJ_G0013040	Snrpn	100	100.000	Mus_pahari
ENSG00000128739	SNRPN	100	100.000	MGP_SPRETEiJ_G0030918	Snrpn	100	100.000	Mus_spretus
ENSG00000128739	SNRPN	100	67.797	ENSMPUG00000007115	-	64	70.423	Mustela_putorius_furo
ENSG00000128739	SNRPN	100	100.000	ENSMPUG00000014638	-	100	99.583	Mustela_putorius_furo
ENSG00000128739	SNRPN	81	85.417	ENSMLUG00000025849	-	73	63.291	Myotis_lucifugus
ENSG00000128739	SNRPN	99	100.000	ENSMLUG00000023361	-	98	99.163	Myotis_lucifugus
ENSG00000128739	SNRPN	81	81.250	ENSMLUG00000024428	-	62	71.111	Myotis_lucifugus
ENSG00000128739	SNRPN	100	100.000	ENSNGAG00000000181	Snrpn	100	100.000	Nannospalax_galili
ENSG00000128739	SNRPN	100	100.000	ENSNLEG00000001376	SNRPN	99	83.750	Nomascus_leucogenys
ENSG00000128739	SNRPN	95	92.547	ENSODEG00000016065	-	87	86.473	Octodon_degus
ENSG00000128739	SNRPN	100	100.000	ENSODEG00000013478	-	100	99.583	Octodon_degus
ENSG00000128739	SNRPN	100	100.000	ENSODEG00000020110	-	100	99.167	Octodon_degus
ENSG00000128739	SNRPN	100	99.408	ENSODEG00000019708	-	95	99.559	Octodon_degus
ENSG00000128739	SNRPN	100	100.000	ENSOCUG00000003532	-	100	99.585	Oryctolagus_cuniculus
ENSG00000128739	SNRPN	100	96.610	ENSORLG00020007490	SNRPN	70	93.491	Oryzias_latipes_hni
ENSG00000128739	SNRPN	100	96.610	ENSORLG00015003332	SNRPN	70	93.491	Oryzias_latipes_hsok
ENSG00000128739	SNRPN	100	98.305	ENSOMEG00000002066	SNRPN	70	94.083	Oryzias_melastigma
ENSG00000128739	SNRPN	100	100.000	ENSOGAG00000007392	SNRPN	100	100.000	Otolemur_garnettii
ENSG00000128739	SNRPN	100	100.000	ENSOARG00000009080	SNRPN	100	98.750	Ovis_aries
ENSG00000128739	SNRPN	93	74.545	ENSPPAG00000034049	-	65	79.720	Pan_paniscus
ENSG00000128739	SNRPN	100	100.000	ENSPPAG00000027650	SNRPN	100	100.000	Pan_paniscus
ENSG00000128739	SNRPN	100	100.000	ENSPPRG00000019878	-	100	99.583	Panthera_pardus
ENSG00000128739	SNRPN	90	71.053	ENSPPRG00000006957	-	73	71.053	Panthera_pardus
ENSG00000128739	SNRPN	100	100.000	ENSPTIG00000004537	SNRPN	100	99.167	Panthera_tigris_altaica
ENSG00000128739	SNRPN	93	76.364	ENSPTRG00000052400	-	65	80.420	Pan_troglodytes
ENSG00000128739	SNRPN	100	100.000	ENSPTRG00000006826	SNRPN	100	100.000	Pan_troglodytes
ENSG00000128739	SNRPN	100	100.000	ENSPANG00000020142	SNRPN	100	100.000	Papio_anubis
ENSG00000128739	SNRPN	100	100.000	ENSPEMG00000012911	-	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000128739	SNRPN	100	97.041	ENSPEMG00000020979	-	89	95.775	Peromyscus_maniculatus_bairdii
ENSG00000128739	SNRPN	100	100.000	ENSPEMG00000013920	-	100	89.583	Peromyscus_maniculatus_bairdii
ENSG00000128739	SNRPN	98	100.000	ENSPCIG00000004699	-	68	94.836	Phascolarctos_cinereus
ENSG00000128739	SNRPN	100	96.610	ENSPMEG00000020674	SNRPN	70	93.491	Poecilia_mexicana
ENSG00000128739	SNRPN	100	100.000	ENSPPYG00000006269	SNURF	100	100.000	Pongo_abelii
ENSG00000128739	SNRPN	100	100.000	ENSPCOG00000014231	SNRPN	100	100.000	Propithecus_coquereli
ENSG00000128739	SNRPN	100	100.000	ENSRNOG00000059764	Snrpn	100	100.000	Rattus_norvegicus
ENSG00000128739	SNRPN	100	100.000	ENSRBIG00000041765	SNRPN	100	100.000	Rhinopithecus_bieti
ENSG00000128739	SNRPN	100	100.000	ENSRROG00000035157	SNRPN	100	100.000	Rhinopithecus_roxellana
ENSG00000128739	SNRPN	100	100.000	ENSSBOG00000024929	-	100	98.750	Saimiri_boliviensis_boliviensis
ENSG00000128739	SNRPN	100	100.000	ENSSBOG00000000110	-	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000128739	SNRPN	98	100.000	ENSSHAG00000010257	-	89	93.981	Sarcophilus_harrisii
ENSG00000128739	SNRPN	98	100.000	ENSSARG00000000072	SNRPN	100	77.824	Sorex_araneus
ENSG00000128739	SNRPN	100	100.000	ENSSSCG00000028124	SNRPN	100	99.167	Sus_scrofa
ENSG00000128739	SNRPN	100	100.000	ENSTTRG00000010966	SNRPN	89	98.750	Tursiops_truncatus
ENSG00000128739	SNRPN	96	100.000	ENSUAMG00000016284	SNRPN	78	99.552	Ursus_americanus
ENSG00000128739	SNRPN	100	100.000	ENSUMAG00000025589	SNRPN	100	99.583	Ursus_maritimus
ENSG00000128739	SNRPN	100	100.000	ENSVVUG00000017971	SNRPN	94	99.563	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	18951082.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	1533223.	TAS	Component
GO:0005682	U5 snRNP	21873635.	IBA	Component
GO:0005685	U1 snRNP	21873635.	IBA	Component
GO:0005686	U2 snRNP	21873635.	IBA	Component
GO:0005687	U4 snRNP	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0008380	RNA splicing	1533223.	TAS	Process
GO:0009725	response to hormone	-	IEA	Process
GO:0030532	small nuclear ribonucleoprotein complex	7512861.	TAS	Component
GO:0046540	U4/U6 x U5 tri-snRNP complex	21873635.	IBA	Component
GO:0071004	U2-type prespliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.