EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	5002087	Frame_Shift_Del	novel	*S131Mfs14**	0.21
BLCA	chr17	5002528	Missense_Mutation	NA	S165C	0.69
BLCA	chr17	5001246	Nonsense_Mutation	NA	Q70*	0.22
BLCA	chr17	5002554	Silent	NA	L174L	0.21
BLCA	chr17	5022580	Silent	NA	L833L	0.29
BLCA	chr17	5007489	Missense_Mutation	NA	G480R	0.18
BLCA	chr17	5024167	3'UTR	novel		0.1
BLCA	chr17	5002073	Silent	NA	L126L	0.42
BLCA	chr17	5023580	Missense_Mutation	rs779132007	P914L	0.49
BRCA	chr17	5003675	Missense_Mutation	NA	G262S	0.43
BRCA	chr17	5002791	Silent	rs375834968	I223I	0.15
BRCA	chr17	5022395	Missense_Mutation	rs780072767	E772Q	0.18
BRCA	chr17	5000303	Silent	NA	E19E	0.21
BRCA	chr17	5002517	Missense_Mutation	NA	K161N	0.41
BRCA	chr17	5002124	Missense_Mutation	NA	E143D	0.2
BRCA	chr17	5004976	Missense_Mutation	NA	G381R	0.18
BRCA	chr17	5023961	Missense_Mutation	rs201887996	R1041Q	0.13
CESC	chr17	5020013	Missense_Mutation	novel	P562S	0.33
CESC	chr17	5022181	Silent	rs763581921	P700P	0.31
CESC	chr17	5022415	Missense_Mutation	NA	K778N	0.24
CESC	chr17	5022265	Silent	NA	I728I	0.37
CESC	chr17	5000779	Missense_Mutation	rs377337240	I38M	0.4
CESC	chr17	5013695	Missense_Mutation	novel	E512Q	0.41
CHOL	chr17	5007289	Silent	novel	L454L	0.12
COAD	chr17	5002534	Missense_Mutation	rs199962814	R167Q	0.32
COAD	chr17	5020527	Missense_Mutation	rs771628064	R596C	0.22
COAD	chr17	5023759	Missense_Mutation	rs550136320	D974N	0.26
COAD	chr17	5000837	Missense_Mutation	NA	S58P	0.42
COAD	chr17	5022560	Missense_Mutation	NA	G827W	0.43
COAD	chr17	5020527	Missense_Mutation	rs771628064	R596C	0.23
COAD	chr17	5023717	Frame_Shift_Del	NA	*L962Cfs126**	0.31
COAD	chr17	5020591	Missense_Mutation	novel	P617L	0.43
COAD	chr17	5022631	Silent	novel	Q850Q	0.38
COAD	chr17	5023975	Missense_Mutation	novel	A1046T	0.46
COAD	chr17	5024005	Frame_Shift_Del	novel	*K1057Sfs31**	0.14
COAD	chr17	5000283	Missense_Mutation	rs756071061	R13W	0.2
COAD	chr17	5024072	Frame_Shift_Ins	novel	*Y1081Ifs15**	0.28
COAD	chr17	5007293	Missense_Mutation	NA	E456K	0.24
COAD	chr17	5007021	Silent	NA	E424E	0.37
ESCA	chr17	5023559	Missense_Mutation	rs199975737	R907H	0.48
GBM	chr17	5023615	Missense_Mutation	rs765376957	R926W	0.09
GBM	chr17	5020497	Missense_Mutation	novel	R586G	0.11
GBM	chr17	5002769	Missense_Mutation	novel	R216H	0.33
GBM	chr17	5023651	Missense_Mutation	NA	R938C	0.22
GBM	chr17	5020665	Missense_Mutation	novel	E642K	0.26
GBM	chr17	5022236	Missense_Mutation	rs147429300	R719C	0.44
GBM	chr17	5022278	Frame_Shift_Del	novel	*R733Gfs15**	0.12
HNSC	chr17	5003865	Silent	novel	I271I	0.23
HNSC	chr17	5022210	Missense_Mutation	novel	R710H	0.21
HNSC	chr17	5007049	Missense_Mutation	novel	Q434K	0.22
HNSC	chr17	5020535	Silent	novel	N598N	0.29
HNSC	chr17	5020536	Missense_Mutation	novel	H599Y	0.29
HNSC	chr17	5023532	Missense_Mutation	novel	A898V	0.21
KIRC	chr17	5022115	Missense_Mutation	novel	D678E	0.06
KIRC	chr17	5013661	Silent	NA	H500H	0.41
KIRC	chr17	5023669	Missense_Mutation	novel	Q944E	0.31
KIRC	chr17	5020608	Missense_Mutation	NA	D623N	0.67
LAML	chr17	5002497	Nonsense_Mutation	NA	R155*	0.48
LAML	chr17	5014748	Missense_Mutation	novel	G526D	0.71
LGG	chr17	5002111	Missense_Mutation	novel	S139F	0.05
LGG	chr17	5004593	Missense_Mutation	rs769968364	A323T	0.31
LIHC	chr17	5024130	Missense_Mutation	novel	K1097N	0.15
LIHC	chr17	5002119	Missense_Mutation	NA	V142M	0.45
LIHC	chr17	5020512	Missense_Mutation	NA	K591E	0.17
LUAD	chr17	5004602	Missense_Mutation	novel	S326C	0.4
LUAD	chr17	5004579	Missense_Mutation	novel	R318L	0.36
LUAD	chr17	5002539	Missense_Mutation	rs587777198	R169W	0.28
LUAD	chr17	5002539	Missense_Mutation	rs587777198	R169W	0.24
LUAD	chr17	5020677	Missense_Mutation	novel	R646W	0.52
LUAD	chr17	5020678	Missense_Mutation	novel	R646K	0.56
LUAD	chr17	5023924	Missense_Mutation	novel	P1029S	0.33
LUAD	chr17	5013730	Splice_Region	novel	T523T	0.41
LUAD	chr17	5022102	Frame_Shift_Ins	novel	*D675Gfs5**	0.05
LUAD	chr17	5024297	3'UTR	novel		0.25
LUAD	chr17	5023977	Silent	rs547354388	A1046A	0.38
LUSC	chr17	5023787	Missense_Mutation	novel	S983N	0.2
LUSC	chr17	5007281	Missense_Mutation	NA	A452P	0.64
LUSC	chr17	5024139	Silent	novel	G1100G	0.24
LUSC	chr17	5002572	Missense_Mutation	novel	D180Y	0.45
LUSC	chr17	5004924	Silent	novel	I363I	0.08
LUSC	chr17	5003661	Missense_Mutation	NA	S257F	0.89
LUSC	chr17	5003662	Silent	NA	S257S	0.89
LUSC	chr17	5004599	Missense_Mutation	novel	L325V	0.07
LUSC	chr17	5023486	Missense_Mutation	novel	E883K	0.42
OV	chr17	5004043	Missense_Mutation	novel	V304M	0.08
OV	chr17	5020541	Silent	rs200771979	P600P	0.24
OV	chr17	5007308	Missense_Mutation	novel	K461Q	0.26
OV	chr17	5007035	Missense_Mutation	novel	P429H	0.27
OV	chr17	5003641	Silent	novel	A250A	0.39
PAAD	chr17	5002630	Missense_Mutation	novel	G199E	0.09
PRAD	chr17	5024090	Missense_Mutation	novel	P1084L	0.37
PRAD	chr17	5023726	Missense_Mutation	rs768222656	R963C	0.28
PRAD	chr17	5023711	Missense_Mutation	rs200230098	R958W	0.56
READ	chr17	5023515	Silent	rs200822779	P892P	0.48
SARC	chr17	5002780	Missense_Mutation	rs760757050	V220I	0.05
SARC	chr17	5022395	Missense_Mutation	novel	E772K	0.17
SARC	chr17	5004940	Missense_Mutation	novel	E369Q	0.14
SARC	chr17	5004942	Frame_Shift_Ins	novel	*V370Sfs10**	0.14
SKCM	chr17	5023579	Missense_Mutation	NA	P914S	0.52
SKCM	chr17	5024096	Missense_Mutation	rs139942468	R1086Q	0.1
SKCM	chr17	5023633	Missense_Mutation	rs777872350	P932S	0.23
SKCM	chr17	5002597	Missense_Mutation	rs777596594	S188F	0.4
SKCM	chr17	5023854	Silent	NA	P1005P	0.5
SKCM	chr17	5007500	Silent	novel	V483V	0.31
SKCM	chr17	5007501	Missense_Mutation	rs571606260	R484W	0.31
SKCM	chr17	5023754	Missense_Mutation	novel	P972L	0.46
SKCM	chr17	5020000	Silent	NA	V557V	0.75
SKCM	chr17	5023855	Missense_Mutation	novel	P1006S	0.23
SKCM	chr17	5023583	Missense_Mutation	novel	S915W	0.28
SKCM	chr17	5022556	Silent	NA	A825A	0.6
SKCM	chr17	5024089	Missense_Mutation	NA	P1084S	0.43
SKCM	chr17	5022580	Silent	novel	L833L	0.45
SKCM	chr17	5022581	Missense_Mutation	rs575669774	R834W	0.42
SKCM	chr17	5023740	Silent	rs762359132	A967A	0.78
SKCM	chr17	5023522	Missense_Mutation	novel	G895R	0.21
SKCM	chr17	5023651	Missense_Mutation	NA	R938C	0.91
SKCM	chr17	5003868	Missense_Mutation	NA	N272K	0.06
SKCM	chr17	5024196	3'UTR	novel		0.34
SKCM	chr17	5020638	Missense_Mutation	NA	E633K	0.67
SKCM	chr17	5024096	Missense_Mutation	rs139942468	R1086Q	0.41
SKCM	chr17	5023965	Silent	novel	G1042G	0.39
SKCM	chr17	5023966	Missense_Mutation	novel	A1043T	0.4
SKCM	chr17	5023550	Missense_Mutation	NA	P904L	0.41
SKCM	chr17	5002521	Missense_Mutation	rs780907252	R163W	0.09
SKCM	chr17	5004027	Silent	NA	I298I	0.32
SKCM	chr17	5004028	Missense_Mutation	NA	P299S	0.17
SKCM	chr17	5023902	Silent	novel	P1021P	0.32
SKCM	chr17	5024130	Missense_Mutation	NA	K1097N	0.23
SKCM	chr17	5023583	Missense_Mutation	rs549971892	S915L	0.24
STAD	chr17	5023552	Missense_Mutation	novel	S905G	0.23
STAD	chr17	5007071	Missense_Mutation	NA	M441T	0.27
STAD	chr17	5002521	Missense_Mutation	rs780907252	R163W	0.37
STAD	chr17	5023928	Missense_Mutation	rs139120839	R1030H	0.36
STAD	chr17	5022544	Silent	novel	S821S	0.38
STAD	chr17	5002808	Missense_Mutation	NA	C229F	0.4
STAD	chr17	5002600	Missense_Mutation	NA	Y189C	0.1
STAD	chr17	5004949	Missense_Mutation	rs201287076	R372W	0.3
STAD	chr17	5020574	Frame_Shift_Del	NA	*P613Hfs27**	0.15
STAD	chr17	5022405	Missense_Mutation	novel	A775V	0.36
STAD	chr17	5022199	Silent	NA	T706T	0.21
STAD	chr17	5004880	Missense_Mutation	rs187228739	R349C	0.32
STAD	chr17	5023852	Frame_Shift_Del	novel	*P1006Lfs82**	0.39
STAD	chr17	5002499	Silent	NA	R155R	0.21
STAD	chr17	5023717	Missense_Mutation	rs757104315	G960R	0.24
STAD	chr17	5023971	Silent	NA	G1044G	0.21
STAD	chr17	5020574	Frame_Shift_Del	NA	*P613Hfs27**	0.69
STAD	chr17	5013724	Silent	rs376123205	G521G	0.21
STAD	chr17	5002823	Missense_Mutation	rs201655443	T234M	0.47
THCA	chr17	5024332	3'UTR	novel		0.29
UCEC	chr17	5024002	Missense_Mutation	NA	P1055S	0.26
UCEC	chr17	5002631	Silent	novel	G199G	0.2
UCEC	chr17	5002792	Missense_Mutation	rs776580434	V224I	0.39
UCEC	chr17	5002544	Silent	NA	E170E	0.35
UCEC	chr17	5002824	Silent	rs150944204	T234T	0.39
UCEC	chr17	5023486	Nonsense_Mutation	NA	E883*	0.23
UCEC	chr17	5004866	Missense_Mutation	rs539953623	R344H	0.44
UCEC	chr17	5020521	Missense_Mutation	rs745324466	V594I	0.26
UCEC	chr17	5014777	Missense_Mutation	rs759883791	G536R	0.24
UCEC	chr17	5003682	Missense_Mutation	rs774939825	R264H	0.38
UCEC	chr17	5022407	Missense_Mutation	rs117621046	A776T	0.44
UCEC	chr17	5020625	Missense_Mutation	NA	Q628H	0.12
UCEC	chr17	5023967	Missense_Mutation	rs373541138	A1043V	0.15
UCEC	chr17	5002499	Silent	NA	R155R	0.44
UCEC	chr17	5020653	Missense_Mutation	novel	D638N	0.09
UCEC	chr17	5020875	Silent	novel	R669R	0.23
UCEC	chr17	5022592	Silent	rs746348476	I837I	0.45
UCEC	chr17	5020057	Silent	novel	T576T	0.31
UCEC	chr17	5023713	Silent	novel	R958R	0.42
UCEC	chr17	5024334	3'UTR	novel		0.42
UCEC	chr17	5022455	Missense_Mutation	novel	P792S	0.53
UCEC	chr17	5023909	Nonsense_Mutation	rs372792586	R1024*	0.37
UCEC	chr17	5024004	Frame_Shift_Ins	novel	*H1058Afs38**	0.5
UCEC	chr17	5002549	Missense_Mutation	NA	P172L	0.43
UCEC	chr17	5002793	Missense_Mutation	novel	V224A	0.41
UCEC	chr17	5001304	Missense_Mutation	novel	Y89C	0.27
UCEC	chr17	5003632	Silent	novel	V247V	0.44
UCEC	chr17	5007282	Missense_Mutation	novel	A452V	0.26
UCEC	chr17	5022333	Missense_Mutation	novel	A751V	0.5
UCEC	chr17	5022130	Silent	NA	R683R	0.33
UCEC	chr17	5004011	Missense_Mutation	rs774589252	R293Q	0.33
UCEC	chr17	5001326	Silent	novel	Y96Y	0.1
UCEC	chr17	5007076	Missense_Mutation	novel	R443G	0.26
UCEC	chr17	5023576	Frame_Shift_Del	novel	*S915Rfs173**	0.55
UCEC	chr17	5022581	Silent	novel	R834R	0.34
UCEC	chr17	5024456	3'UTR	novel		0.16
UCEC	chr17	5001343	Missense_Mutation	novel	G102E	0.23
UCEC	chr17	5023681	Missense_Mutation	rs764527829	R948W	0.21
UCEC	chr17	5022190	Silent	rs372267137	T703T	0.3
UCEC	chr17	5002492	Missense_Mutation	rs528902778	R153Q	0.37
UCEC	chr17	5007030	Missense_Mutation	novel	F427L	0.42
UCEC	chr17	5022576	Missense_Mutation	novel	D832G	0.41
UCEC	chr17	5000299	Missense_Mutation	rs756916879	R18H	0.05
UCEC	chr17	5020832	Missense_Mutation	novel	R655Q	0.38
UCEC	chr17	5007045	Silent	novel	E432E	0.15
UCEC	chr17	5000298	Missense_Mutation	rs199632760	R18C	0.22
UCEC	chr17	5022384	Missense_Mutation	rs552440254	R768Q	0.4
UCEC	chr17	5023743	Silent	NA	R968R	0.5
UCEC	chr17	5024053	Missense_Mutation	rs748194713	R1072W	0.12
UCEC	chr17	5024208	3'UTR	novel		0.16
UCEC	chr17	5022198	Missense_Mutation	novel	T706I	0.34
UCEC	chr17	5007476	Silent	novel	L475L	0.29
UCEC	chr17	5022432	Missense_Mutation	rs774940396	R784H	0.38
UCEC	chr17	5002124	Missense_Mutation	NA	E143D	0.37
UCEC	chr17	5002806	Silent	novel	R228R	0.3
UCEC	chr17	5013677	Missense_Mutation	novel	E506K	0.2
UCEC	chr17	5023902	Silent	novel	P1021P	0.23
UCEC	chr17	5024110	Missense_Mutation	rs755305909	R1091C	0.17
UCEC	chr17	5002564	Missense_Mutation	novel	Y177F	0.42
UCEC	chr17	5023813	Missense_Mutation	novel	P992S	0.33
UCEC	chr17	5013725	Missense_Mutation	novel	V522I	0.4
UCEC	chr17	5022333	Missense_Mutation	novel	A751V	0.41
UCEC	chr17	5014822	Nonsense_Mutation	novel	Q551*	0.13
UCEC	chr17	5020554	Silent	novel	L605L	0.46
UCEC	chr17	5024675	3'UTR	novel		0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.5486	3.9592e-10
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.029	Kaplan-Meier Survival Analysis
UCS	0.034	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
LUSC	0.01	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.01	Kaplan-Meier Survival Analysis
LAML	0.029	Kaplan-Meier Survival Analysis
KICH	0.031	Kaplan-Meier Survival Analysis
UCEC	0.029	Kaplan-Meier Survival Analysis
DLBC	0.016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000129250 (Gene tree)
Gene ID: 10749
Gene Symbol: KIF1C
Alias: SPAX2|SPG58|SAX2
Full Name: kinesin family member 1C
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 30,454 bases
Position: chr17:4,997,948-5,028,401
Accession: 6317
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000573815	KIF1C-203	726	-	-	- (aa)	-	-
ENST00000320785	KIF1C-201	7919	XM_005256424	ENSP00000320821	1103 (aa)	XP_005256481	O43896
ENST00000572959	KIF1C-202	590	-	-	- (aa)	-	-
ENST00000574165	KIF1C-204	799	-	ENSP00000458697	138 (aa)	-	I3L1B1

Gene Model

Click here to download ENSG00000129250's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000129250	Sleep	6E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000129250	rs11658587	17	4998687	A	Obesity-related traits	23251661	[NR] min/d increase	0.03	EFO_0004870
ENSG00000129250	rs238282	17	5018833	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129250's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000129250	KIF1C	100	97.826	ENSMUSG00000020821	Kif1c	100	93.019	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003774	motor activity	9685376.	TAS	Function
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0005515	protein binding	20360680.24482476.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005783	endoplasmic reticulum	9685376.	TAS	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	IEA	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	21873635.	IBA	Function
GO:0016192	vesicle-mediated transport	21873635.	IBA	Process
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0030424	axon	21873635.	IBA	Component
GO:0030425	dendrite	21873635.	IBA	Component
GO:0030705	cytoskeleton-dependent intracellular transport	21873635.	IBA	Process
GO:0043005	neuron projection	21873635.	IBA	Component
GO:1904115	axon cytoplasm	-	IEA	Component
GO:1990048	anterograde neuronal dense core vesicle transport	-	ISS	Process
GO:1990049	retrograde neuronal dense core vesicle transport	-	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.