Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
---|---|---|---|---|---|---|---|
ACC | |||||||
BLCA | |||||||
BLCA | |||||||
BRCA | |||||||
BRCA | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CHOL | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
ESCA | |||||||
GBM | |||||||
GBM | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
KIRP | |||||||
LGG | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
OV | |||||||
PAAD | |||||||
PRAD | |||||||
PRAD | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
STAD | |||||||
STAD | |||||||
THYM | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC |
Cancer | Type | Freq | Q-value |
---|---|---|---|
ACC | |||
CHOL | |||
KIRP | |||
PAAD |
Cancer | P-value | Q-value |
---|---|---|
THYM | ||
KIRC | ||
MESO | ||
HNSC | ||
SKCM | ||
PAAD | ||
CESC | ||
KICH | ||
UCEC | ||
LIHC | ||
DLBC | ||
LGG | ||
LUAD | ||
UVM |
Protein ID | Domain | Pfam ID | E-value | Domain number | Total number |
---|---|---|---|---|---|
ENSP00000447470 | 2OG-FeII_Oxy | PF03171.20 | 1.5e-05 | 1 | 1 |
PID | Title | Article | Time | Author | Doi |
---|---|---|---|---|---|
20460131 |
Transcript ID | Name | Length | RefSeq ID | Protein ID | Length | RefSeq ID | UniportKB ID |
---|---|---|---|---|---|---|---|
ENST00000546681 | EGLN3-204 | 581 | - | - | - (aa) | - | - |
ENST00000551935 | EGLN3-208 | 575 | - | - | - (aa) | - | - |
ENST00000553215 | EGLN3-209 | 1004 | - | ENSP00000447470 | 145 (aa) | - | F8W1G2 |
ENST00000487915 | EGLN3-203 | 848 | - | ENSP00000451316 | 79 (aa) | - | G3V3M1 |
ENST00000547327 | EGLN3-205 | 2849 | - | ENSP00000446572 | 148 (aa) | - | F8VR39 |
ENST00000556785 | EGLN3-210 | 864 | - | - | - (aa) | - | - |
ENST00000250457 | EGLN3-201 | 2709 | - | ENSP00000250457 | 239 (aa) | - | Q9H6Z9 |
ENST00000550114 | EGLN3-207 | 566 | - | - | - (aa) | - | - |
ENST00000557521 | EGLN3-211 | 658 | - | - | - (aa) | - | - |
ENST00000464521 | EGLN3-202 | 352 | - | - | - (aa) | - | - |
ENST00000548285 | EGLN3-206 | 535 | - | - | - (aa) | - | - |
ensgID | Trait | pValue | Pubmed ID |
---|---|---|---|
ENSG00000129521 | Fibrinogen | 5.07816651189167E-5 | 17903294 |
ENSG00000129521 | Fibrinogen | 2.38174494351447E-6 | 17903294 |
ENSG00000129521 | Varicose Veins | 8.3543782868123E-5 | - |
ENSG00000129521 | Osteoporosis | 6.49678632189676E-5 | 17903295 |
ENSG00000129521 | Mental Competency | 1.84886412635623E-6 | 17903295 |
ENSG00000129521 | Stroke | 5.5631319E-005 | 19369658 |
ENSG00000129521 | Neuroblastoma | 1.71e-005 | 23222812 |
ENSG00000129521 | Waist-Hip Ratio | 4.4450000E-006 | - |
ENSG00000129521 | Waist-Hip Ratio | 1.0540000E-005 | - |
ENSG00000129521 | Basophils | 4.4380000E-005 | - |
ENSG00000129521 | Platelet Function Tests | 1.1900000E-007 | - |
ENSG00000129521 | Platelet Function Tests | 4.7000000E-007 | - |
ENSG00000129521 | Child Development Disorders, Pervasive | 6.5441600E-005 | - |
ENSG00000129521 | Child Development Disorders, Pervasive | 1.4527000E-005 | - |
ENSG00000129521 | Child Development Disorders, Pervasive | 6.0145500E-005 | - |
ENSG00000129521 | Child Development Disorders, Pervasive | 1.0189500E-005 | - |
ENSG00000129521 | alpha-carotene | 4.5640000E-006 | - |
ENSG00000129521 | alpha-carotene | 2.8980000E-006 | - |
ENSG00000129521 | Taste Perception | 3.2450000E-005 | - |
ENSG00000129521 | Age-Related Hearing Impairment 1 | 8E-6 | 24939585 |
ENSG00000129521 | 3-hydroxy-1-methylpropylmercapturic acid | 3E-6 | 26053186 |
ENSG00000129521 | Smoking | 3E-6 | 26053186 |
ENSG00000129521 | Rest | 8E-7 | 27126917 |
ENSG00000129521 | Celiac Disease | 4E-6 | 23936387 |
ensgID | SNP | Chromosome | Position | SNP-risk | Trait | PubmedID | 95% CI | Or or BEAT | EFO ID |
---|---|---|---|---|---|---|---|---|---|
ENSG00000129521 | rs1958581 | 14 | 34332393 | ? | Age-related hearing impairment | 24939585 | [NR] unit decrease | 0.1353 | EFO_0005782 |
ENSG00000129521 | rs57574493 | 14 | 34149063 | G | Daytime sleep phenotypes | 27126917 | [0.4-0.98] unit increase | 0.6878 | EFO_0007828 |
ENSG00000129521 | rs797324 | 14 | 34136247 | C | Daytime sleep phenotypes | 27126917 | [0.34-0.79] unit increase | 0.5679 | EFO_0007828 |
ENSG00000129521 | rs1958589 | 14 | 34375170 | C | Celiac disease | 23936387 | EFO_0001060 | ||
ENSG00000129521 | rs191936903 | 14 | 34027246 | ? | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers | 26053186 | [NR] unit decrease | 1.1003 | EFO_0004318|EFO_0007015 |
ENSG00000129521 | rs10142635 | 14 | 34423401 | A | Heart rate response to beta blockers (atenolol add-on therapy) | 29478026 | [4.16-9.06] bpm decrease | 6.61 | EFO_0007766|EFO_0004326 |
ENSG00000129521 | rs76827035 | 14 | 34324633 | G | Eotaxin levels | 27989323 | [0.1-0.255] SD units increase | 0.1776 | EFO_0008122 |
ENSG00000129521 | rs797343 | 14 | 34177063 | T | Hematocrit | 27863252 | [0.015-0.03] unit increase | 0.02249192 | EFO_0004348 |
ENSG00000129521 | rs12879626 | 14 | 34251928 | T | Intraocular pressure | 29785010 | [0.054-0.104] unit increase | 0.079 | EFO_0004695 |
ENSG00000129521 | rs74412765 | 14 | 34053698 | T | Reasoning | 29907492 | [NR] unit decrease | 1.7 | EFO_0004350 |
ENSG00000129521 | rs797343 | 14 | 34177063 | ? | Red blood cell count | 30595370 | EFO_0004305 | ||
ENSG00000129521 | rs35833468 | 14 | 33974720 | ? | Alzheimer's disease (late onset) | 30820047 | [1.04-1.12] | 1.0869565 | EFO_1001870 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Ortholog | Gene Symbol | Coverage | Identiy | Species |
---|---|---|---|---|---|---|---|---|
ENSG00000129521 | EGLN3 | 99 | 83.333 | ENSAPOG00000007757 | egln3 | 99 | 64.502 | Acanthochromis_polyacanthus |
ENSG00000129521 | EGLN3 | 99 | 80.769 | ENSAOCG00000023534 | egln3 | 99 | 62.338 | Amphiprion_ocellaris |
ENSG00000129521 | EGLN3 | 97 | 79.221 | ENSAOCG00000000273 | - | 98 | 75.424 | Amphiprion_ocellaris |
ENSG00000129521 | EGLN3 | 97 | 79.221 | ENSAOCG00000019598 | - | 98 | 76.271 | Amphiprion_ocellaris |
ENSG00000129521 | EGLN3 | 99 | 80.769 | ENSAPEG00000013864 | egln3 | 100 | 61.181 | Amphiprion_percula |
ENSG00000129521 | EGLN3 | 99 | 83.333 | ENSAPEG00000000070 | - | 100 | 62.393 | Amphiprion_percula |
ENSG00000129521 | EGLN3 | 99 | 84.615 | ENSATEG00000016315 | egln3 | 85 | 83.810 | Anabas_testudineus |
ENSG00000129521 | EGLN3 | 97 | 100.000 | ENSANAG00000037222 | EGLN3 | 100 | 99.160 | Aotus_nancymaae |
ENSG00000129521 | EGLN3 | 100 | 86.076 | ENSACLG00000007509 | egln3 | 98 | 66.239 | Astatotilapia_calliptera |
ENSG00000129521 | EGLN3 | 99 | 84.615 | ENSAMXG00000002702 | egln3 | 100 | 66.109 | Astyanax_mexicanus |
ENSG00000129521 | EGLN3 | 99 | 98.718 | ENSCAFG00000013182 | EGLN3 | 88 | 94.574 | Canis_familiaris |
ENSG00000129521 | EGLN3 | 99 | 100.000 | ENSTSYG00000002267 | - | 100 | 99.160 | Carlito_syrichta |
ENSG00000129521 | EGLN3 | 97 | 98.701 | ENSCAPG00000014697 | - | 89 | 88.136 | Cavia_aperea |
ENSG00000129521 | EGLN3 | 97 | 97.403 | ENSCGRG00000000933 | - | 100 | 97.368 | Cricetulus_griseus_crigri |
ENSG00000129521 | EGLN3 | 100 | 86.076 | ENSHBUG00000015449 | egln3 | 95 | 66.239 | Haplochromis_burtoni |
ENSG00000129521 | EGLN3 | 99 | 84.615 | ENSIPUG00000001099 | egln3 | 98 | 68.696 | Ictalurus_punctatus |
ENSG00000129521 | EGLN3 | 99 | 89.744 | ENSLOCG00000009500 | egln3 | 100 | 75.417 | Lepisosteus_oculatus |
ENSG00000129521 | EGLN3 | 99 | 85.897 | ENSMAMG00000000031 | egln3 | 97 | 68.376 | Mastacembelus_armatus |
ENSG00000129521 | EGLN3 | 100 | 86.076 | ENSMZEG00005001042 | egln3 | 85 | 64.103 | Maylandia_zebra |
ENSG00000129521 | EGLN3 | 100 | 94.937 | ENSMGAG00000012453 | EGLN3 | 100 | 91.870 | Meleagris_gallopavo |
ENSG00000129521 | EGLN3 | 97 | 84.416 | ENSMMOG00000013295 | egln3 | 97 | 76.068 | Mola_mola |
ENSG00000129521 | EGLN3 | 100 | 78.481 | ENSORLG00000018068 | egln3 | 94 | 63.559 | Oryzias_latipes |
ENSG00000129521 | EGLN3 | 100 | 78.481 | ENSORLG00020010688 | egln3 | 94 | 62.979 | Oryzias_latipes_hni |
ENSG00000129521 | EGLN3 | 100 | 78.481 | ENSORLG00015007682 | egln3 | 94 | 62.553 | Oryzias_latipes_hsok |
ENSG00000129521 | EGLN3 | 100 | 78.481 | ENSOMEG00000005866 | egln3 | 97 | 62.553 | Oryzias_melastigma |
ENSG00000129521 | EGLN3 | 100 | 99.310 | ENSPTIG00000017846 | EGLN3 | 100 | 99.310 | Panthera_tigris_altaica |
ENSG00000129521 | EGLN3 | 99 | 80.769 | ENSPFOG00000010877 | egln3 | 94 | 65.812 | Poecilia_formosa |
ENSG00000129521 | EGLN3 | 99 | 80.769 | ENSPLAG00000023868 | egln3 | 97 | 65.812 | Poecilia_latipinna |
ENSG00000129521 | EGLN3 | 99 | 80.769 | ENSPMEG00000002851 | egln3 | 97 | 65.812 | Poecilia_mexicana |
ENSG00000129521 | EGLN3 | 99 | 82.051 | ENSPREG00000002945 | egln3 | 97 | 66.239 | Poecilia_reticulata |
ENSG00000129521 | EGLN3 | 97 | 92.405 | ENSPCOG00000013527 | - | 100 | 92.562 | Propithecus_coquereli |
ENSG00000129521 | EGLN3 | 99 | 94.872 | ENSPVAG00000002170 | EGLN3 | 100 | 91.509 | Pteropus_vampyrus |
ENSG00000129521 | EGLN3 | 99 | 85.897 | ENSPNAG00000008631 | egln3 | 99 | 68.644 | Pygocentrus_nattereri |
ENSG00000129521 | EGLN3 | 99 | 89.744 | ENSSFOG00015014197 | egln3 | 80 | 67.662 | Scleropages_formosus |
ENSG00000129521 | EGLN3 | 99 | 84.615 | ENSSDUG00000010655 | egln3 | 97 | 68.240 | Seriola_dumerili |
ENSG00000129521 | EGLN3 | 97 | 97.403 | ENSSPUG00000013593 | - | 100 | 94.958 | Sphenodon_punctatus |
ENSG00000129521 | EGLN3 | 99 | 83.333 | ENSSPAG00000007191 | egln3 | 98 | 65.417 | Stegastes_partitus |
ENSG00000129521 | EGLN3 | 100 | 78.481 | ENSTNIG00000002846 | egln3 | 92 | 64.414 | Tetraodon_nigroviridis |
ENSG00000129521 | EGLN3 | 99 | 98.718 | ENSUMAG00000010391 | EGLN3 | 91 | 98.333 | Ursus_maritimus |
ENSG00000129521 | EGLN3 | 97 | 98.701 | ENSVVUG00000029949 | - | 100 | 99.160 | Vulpes_vulpes |
Go ID | Go_term | PubmedID | Evidence | Category |
---|---|---|---|---|
GO:0001666 | response to hypoxia | 20978507. | IEP | Process |
GO:0005506 | iron ion binding | - | IEA | Function |
GO:0005515 | protein binding | 15721254.16511565.17353276.19584355.20849813.21575608.21620138.21988832.22286099.25416956.26972000. | IPI | Function |
GO:0005634 | nucleus | 12615973. | IDA | Component |
GO:0005654 | nucleoplasm | - | TAS | Component |
GO:0005737 | cytoplasm | 12615973. | IDA | Component |
GO:0005829 | cytosol | - | IDA | Component |
GO:0005829 | cytosol | - | TAS | Component |
GO:0006915 | apoptotic process | 20978507. | IEP | Process |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 20978507. | IEP | Process |
GO:0006974 | cellular response to DNA damage stimulus | - | IEA | Process |
GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | 22955912. | IDA | Function |
GO:0018126 | protein hydroxylation | 19584355. | IDA | Process |
GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 11598268. | IDA | Process |
GO:0031418 | L-ascorbic acid binding | - | IEA | Function |
GO:0031545 | peptidyl-proline 4-dioxygenase activity | 12615973.12788921.22286099. | EXP | Function |
GO:0031545 | peptidyl-proline 4-dioxygenase activity | 11598268. | IDA | Function |
GO:0042127 | regulation of cell proliferation | 20978507. | IEP | Process |
GO:0043523 | regulation of neuron apoptotic process | - | ISS | Process |
GO:0055114 | oxidation-reduction process | - | IEA | Process |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | - | TAS | Process |