EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21478912	Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.	Oncogene	2011 Sep 8	Fournier G	doi: 10.1038/onc.2011.106
27601590	Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.	Clin Cancer Res	2017 Mar 1	Pichler M	doi: 10.1158/1078-0432.CCR-16-0497
26013125	Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression.	Nat Commun	2015 May 26	Xu Y	doi: 10.1038/ncomms8184.
16819513	Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.	Oncogene	2007 Jan 11	Letessier A	-
24373847	Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer.	Biochim Biophys Acta	2014 Mar	Sun TT	-
29159771	CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231.	Mol Cell Biochem	2018 Jun	Yang M	doi: 10.1007/s11010-017-3221-8

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	167826286	5'Flank	novel		0.08
BLCA	chr6	167825934	5'Flank	rs755716451		0.16
BLCA	chr6	167907196	Missense_Mutation	novel	R559K	0.43
BLCA	chr6	167946881	Missense_Mutation	rs766388839	R1171H	0.28
BLCA	chr6	167917101	Frame_Shift_Ins	novel	*T854Yfs4**	0.23
BLCA	chr6	167872284	Nonsense_Mutation	NA	S162*	0.18
BLCA	chr6	167951904	Missense_Mutation	NA	S1510N	0.35
BLCA	chr6	167825721	5'Flank	rs764117945		0.11
BLCA	chr6	167826501	5'Flank	rs768552456		0.5
BLCA	chr6	167952239	Intron	novel		0.13
BLCA	chr6	167825664	5'Flank	novel		0.48
BLCA	chr6	167943961	Missense_Mutation	NA	R1080T	0.27
BLCA	chr6	167825740	5'Flank	novel		0.22
BLCA	chr6	167826553	5'Flank	novel		0.24
BLCA	chr6	167952107	Missense_Mutation	rs201932853	E1578K	0.12
BLCA	chr6	167918841	Missense_Mutation	rs201634310	P932L	0.48
BLCA	chr6	167826157	5'Flank	novel		0.23
BLCA	chr6	167898278	Missense_Mutation	novel	R464T	0.55
BLCA	chr6	167825658	5'Flank	novel		0.36
BLCA	chr6	167889284	Missense_Mutation	novel	E323K	0.26
BLCA	chr6	167918906	Missense_Mutation	rs754362514	E954Q	0.31
BLCA	chr6	167951906	Missense_Mutation	rs141139097	L1511V	0.22
BLCA	chr6	167969864	Nonsense_Mutation	novel	Q1802*	0.28
BLCA	chr6	167825994	5'Flank	novel		0.07
BLCA	chr6	167864650	Missense_Mutation	novel	Q69E	0.52
BLCA	chr6	167925087	Frame_Shift_Del	novel	*A1025Efs9**	0.18
BLCA	chr6	167952184	Silent	rs374331983	A1603A	0.22
BLCA	chr6	167951906	Silent	rs141139097	L1511L	0.43
BLCA	chr6	167915312	Missense_Mutation	rs139174764	S808L	0.15
BLCA	chr6	167826117	5'Flank	rs768311771		0.19
BRCA	chr6	167952063	Missense_Mutation	NA	E1563G	0.53
BRCA	chr6	167969137	Missense_Mutation	NA	T1754S	0.18
BRCA	chr6	167962763	Intron	novel		0.12
BRCA	chr6	167947904	Missense_Mutation	rs765437330	A1195V	0.12
BRCA	chr6	167962640	Intron	novel		0.17
BRCA	chr6	167907211	Missense_Mutation	NA	S564C	0.22
BRCA	chr6	167962469	Missense_Mutation	NA	E1617Q	0.13
BRCA	chr6	167951214	Missense_Mutation	rs140509375	R1280Q	0.2
BRCA	chr6	167911344	Missense_Mutation	NA	K631T	0.37
BRCA	chr6	167911415	Nonsense_Mutation	novel	*S655Kfs2**	0.2
BRCA	chr6	167826083	5'Flank	novel		0.52
BRCA	chr6	167943128	Splice_Site	novel	X1027_splice	0.64
BRCA	chr6	167951574	Missense_Mutation	rs571941763	P1400L	0.37
BRCA	chr6	167951904	Missense_Mutation	NA	S1510N	0.59
BRCA	chr6	167889294	Nonsense_Mutation	NA	L326*	0.29
BRCA	chr6	167889284	Frame_Shift_Ins	novel	*E323Gfs24**	0.25
BRCA	chr6	167907228	Nonsense_Mutation	novel	G570*	0.48
BRCA	chr6	167907242	Silent	novel	P574P	0.21
BRCA	chr6	167947927	Missense_Mutation	NA	G1203R	0.18
BRCA	chr6	167907163	Splice_Site	novel	X551_splice	0.82
BRCA	chr6	167914686	Missense_Mutation	novel	M742I	0.12
BRCA	chr6	167825958	5'Flank	rs763454767		0.13
BRCA	chr6	167826035	5'Flank	novel		0.2
BRCA	chr6	167918871	Missense_Mutation	NA	C942F	0.33
BRCA	chr6	167911402	Nonsense_Mutation	NA	Y650*	0.27
BRCA	chr6	167976073	3'Flank	novel		0.31
BRCA	chr6	167946743	In_Frame_Del	novel	S1126_E1130del	0.17
BRCA	chr6	167826132	5'Flank	novel		0.45
BRCA	chr6	167952079	Missense_Mutation	NA	K1568N	0.21
CESC	chr6	167951941	Silent	novel	E1522E	0.19
CESC	chr6	167962478	Missense_Mutation	NA	R1620C	0.17
CESC	chr6	167907222	Missense_Mutation	NA	E568K	0.18
CESC	chr6	167951299	Silent	NA	Q1308Q	0.17
CESC	chr6	167971787	3'Flank	novel		0.42
CESC	chr6	167918744	Missense_Mutation	novel	E900K	0.25
CESC	chr6	167911372	Missense_Mutation	novel	M640I	0.34
CESC	chr6	167918841	Missense_Mutation	rs201634310	P932L	0.39
CESC	chr6	167951849	Missense_Mutation	rs748333996	R1492C	0.28
CESC	chr6	167976091	3'Flank	novel		0.14
CESC	chr6	167870475	Missense_Mutation	novel	E131K	0.32
CESC	chr6	167946721	Missense_Mutation	novel	G1118C	0.38
CESC	chr6	167913547	Intron	novel		0.29
CESC	chr6	167872331	Nonsense_Mutation	NA	R178*	0.22
CESC	chr6	167969819	Missense_Mutation	NA	E1787K	0.17
CESC	chr6	167826690	5'Flank	NA		0.31
CESC	chr6	167951612	Missense_Mutation	NA	E1413Q	0.66
CESC	chr6	167872309	Silent	NA	K170K	0.47
CESC	chr6	167948476	Missense_Mutation	novel	Q1270E	0.32
CESC	chr6	167826750	5'Flank	NA		0.29
CHOL	chr6	167907206	Silent	novel	S562S	0.39
CHOL	chr6	167947907	Missense_Mutation	novel	K1196T	0.47
CHOL	chr6	167907203	Silent	novel	S561S	0.1
CHOL	chr6	167889252	Missense_Mutation	novel	K312R	0.08
COAD	chr6	167962693	Intron	novel		0.47
COAD	chr6	167976364	3'Flank	novel		0.06
COAD	chr6	167976591	3'Flank	novel		0.01
COAD	chr6	167976803	3'Flank	novel		0.17
COAD	chr6	167826249	5'Flank	novel		0.43
COAD	chr6	167826042	5'Flank	rs757180520		0.2
COAD	chr6	167952176	Nonsense_Mutation	NA	R1601*	0.19
COAD	chr6	167969111	Splice_Region	NA		0.42
COAD	chr6	167946894	Silent	rs367706314	N1175N	0.28
COAD	chr6	167870469	In_Frame_Del	NA	K129del	0.43
COAD	chr6	167951195	Missense_Mutation	rs768477295	R1274C	0.27
COAD	chr6	167951849	Missense_Mutation	rs748333996	R1492C	0.33
COAD	chr6	167976921	3'Flank	novel		0.53
COAD	chr6	167911419	Missense_Mutation	NA	P656H	0.34
COAD	chr6	167826553	5'Flank	novel		0.46
COAD	chr6	167893861	Splice_Site	NA	X393_splice	0.38
COAD	chr6	167952197	Intron	NA		0.05
COAD	chr6	167952209	Intron	novel		0.31
COAD	chr6	167962858	Intron	rs537314205		0.44
COAD	chr6	167951841	Missense_Mutation	NA	T1489M	0.35
COAD	chr6	167976025	3'Flank	rs527744701		0.26
COAD	chr6	167864683	Nonsense_Mutation	rs778113186	R80*	0.4
COAD	chr6	167925049	Frame_Shift_Del	NA	*K1014Sfs20**	0.34
COAD	chr6	167826358	5'Flank	novel		0.07
COAD	chr6	167925049	Frame_Shift_Del	NA	*K1014Sfs20**	0.15
COAD	chr6	167951473	Silent	rs766768344	P1366P	0.36
COAD	chr6	167911101	Splice_Region	novel	R590R	0.05
COAD	chr6	167943408	Missense_Mutation	NA	R1051C	0.13
COAD	chr6	167875486	Missense_Mutation	NA	P244S	0.44
COAD	chr6	167952116	Missense_Mutation	rs776910572	E1581K	0.53
COAD	chr6	167898361	Frame_Shift_Del	NA	*A493Rfs25**	0.3
COAD	chr6	167951477	Frame_Shift_Del	NA	*P1369Rfs29**	0.38
COAD	chr6	167864676	Missense_Mutation	NA	E77D	0.09
COAD	chr6	167872322	Nonsense_Mutation	NA	E175*	0.13
COAD	chr6	167890865	Missense_Mutation	NA	I338S	0.09
COAD	chr6	167951247	Missense_Mutation	rs759864399	R1291Q	0.13
COAD	chr6	167880376	Missense_Mutation	NA	I252M	0.35
COAD	chr6	167976399	3'Flank	novel		0.34
COAD	chr6	167948429	Frame_Shift_Del	NA	*K1255Sfs38**	0.26
COAD	chr6	167898419	Missense_Mutation	novel	R511I	0.04
COAD	chr6	167976353	3'Flank	novel		0.06
COAD	chr6	167922882	Missense_Mutation	rs778409493	R972C	0.37
COAD	chr6	167951648	Missense_Mutation	rs754436231	R1425C	0.46
COAD	chr6	167911590	Intron	novel		0.33
DLBC	chr6	167969192	Missense_Mutation	novel	S1772F	0.33
ESCA	chr6	167826467	5'Flank	novel		0.08
ESCA	chr6	167946894	Silent	rs367706314	N1175N	0.07
ESCA	chr6	167952184	Silent	rs374331983	A1603A	0.33
ESCA	chr6	167875461	Missense_Mutation	novel	Q235H	0.47
ESCA	chr6	167976659	3'Flank	novel		0.22
ESCA	chr6	167922878	Silent	novel	H970H	0.38
ESCA	chr6	167826690	5'Flank	novel		0.59
GBM	chr6	167943439	Missense_Mutation	novel	V1061A	0.08
GBM	chr6	167943982	Frame_Shift_Del	novel	*L1087Rfs3**	0.06
GBM	chr6	167825765	5'Flank	novel		0.07
GBM	chr6	167943157	Missense_Mutation	NA	Y1036C	0.33
GBM	chr6	167825780	5'Flank	novel		0.35
GBM	chr6	167825782	5'Flank	novel		0.34
GBM	chr6	167825653	5'Flank	novel		0.76
GBM	chr6	167915302	Missense_Mutation	rs775055966	D805N	0.6
GBM	chr6	167925045	Missense_Mutation	novel	T1011I	0.26
GBM	chr6	167951462	Missense_Mutation	novel	D1363Y	0.56
GBM	chr6	167948300	Missense_Mutation	rs145954704	T1211M	0.62
GBM	chr6	167914717	Missense_Mutation	novel	S753R	0.2
GBM	chr6	167962705	Intron	novel		0.12
HNSC	chr6	167965803	Missense_Mutation	novel	R1665H	0.31
HNSC	chr6	167825913	5'Flank	novel		0.09
HNSC	chr6	167880467	Missense_Mutation	novel	E283Q	0.08
HNSC	chr6	167825525	5'Flank	novel		0.25
HNSC	chr6	167864626	Missense_Mutation	rs770846848	R61W	0.24
HNSC	chr6	167943948	Missense_Mutation	novel	E1076K	0.45
HNSC	chr6	167918785	Silent	novel	L913L	0.2
HNSC	chr6	167951855	Missense_Mutation	novel	D1494N	0.22
HNSC	chr6	167951237	Nonsense_Mutation	novel	E1288*	0.09
HNSC	chr6	167951812	Silent	novel	R1479R	0.09
HNSC	chr6	167864621	Nonsense_Mutation	novel	*I60Ffs6**	0.04
HNSC	chr6	167864564	Missense_Mutation	novel	H40R	0.31
HNSC	chr6	167825671	5'Flank	novel		0.15
HNSC	chr6	167952131	Missense_Mutation	rs764193158	D1586N	0.13
HNSC	chr6	167825792	5'Flank	novel		0.21
HNSC	chr6	167875475	Nonsense_Mutation	novel	S240*	0.14
HNSC	chr6	167915319	Silent	novel	L810L	0.08
HNSC	chr6	167946744	Missense_Mutation	novel	K1125N	0.32
KIRC	chr6	167943400	Splice_Site	NA	X1049_splice	0.3
KIRC	chr6	167825888	5'Flank	novel		0.27
KIRC	chr6	167948413	Missense_Mutation	NA	W1249G	0.25
KIRC	chr6	167962520	Missense_Mutation	rs781720897	R1634C	0.21
KIRC	chr6	167943967	Missense_Mutation	NA	S1082I	0.2
KIRC	chr6	167896919	Nonsense_Mutation	NA	Q422*	0.25
KIRC	chr6	167914704	Missense_Mutation	novel	D748E	0.22
KIRP	chr6	167825963	5'Flank	novel		0.47
KIRP	chr6	167948429	Missense_Mutation	NA	E1254V	0.48
KIRP	chr6	167875347	Silent	novel	R197R	0.31
KIRP	chr6	167976782	3'Flank	rs537948372		0.31
KIRP	chr6	167943412	Missense_Mutation	NA	L1052Q	0.43
KIRP	chr6	167911494	Splice_Region	novel		0.4
KIRP	chr6	167946833	Missense_Mutation	novel	K1155R	0.23
KIRP	chr6	167946863	Missense_Mutation	NA	K1165T	0.76
LAML	chr6	167951625	Missense_Mutation	rs779545868	R1417H	0.39
LAML	chr6	167951379	Missense_Mutation	novel	L1335R	0.5
LGG	chr6	167875413	Missense_Mutation	novel	E219D	0.08
LGG	chr6	167880512	Missense_Mutation	NA	A298T	0.1
LGG	chr6	167911135	Missense_Mutation	novel	P602S	0.2
LIHC	chr6	167872302	Frame_Shift_Del	NA	*K170Rfs53**	0.55
LIHC	chr6	167951542	Silent	NA	P1389P	0.1
LIHC	chr6	167965987	Silent	novel	F1726F	0.54
LIHC	chr6	167951846	Nonsense_Mutation	novel	E1491*	0.67
LIHC	chr6	167965935	Missense_Mutation	novel	Q1709L	0.41
LIHC	chr6	167914259	Missense_Mutation	rs149079362	R710Q	0.45
LIHC	chr6	167918765	Nonsense_Mutation	novel	E907*	0.91
LUAD	chr6	167826280	5'Flank	rs371605617		0.39
LUAD	chr6	167948390	Missense_Mutation	novel	R1241L	0.38
LUAD	chr6	167875374	Missense_Mutation	NA	M206I	0.26
LUAD	chr6	167898268	Missense_Mutation	novel	V461L	0.3
LUAD	chr6	167898406	Missense_Mutation	NA	A507T	0.13
LUAD	chr6	167872233	Missense_Mutation	NA	P145H	0.2
LUAD	chr6	167962813	Intron	novel		0.4
LUAD	chr6	167943945	Missense_Mutation	NA	A1075T	0.08
LUAD	chr6	167951575	Silent	NA	P1400P	0.26
LUAD	chr6	167875351	Missense_Mutation	NA	A199S	0.6
LUAD	chr6	167825591	5'Flank	novel		0.3
LUAD	chr6	167951600	Missense_Mutation	rs144643489	R1409W	0.25
LUAD	chr6	167880433	Silent	novel	T271T	0.24
LUAD	chr6	167952200	Intron	novel		0.35
LUAD	chr6	167952081	Missense_Mutation	novel	R1569K	0.17
LUAD	chr6	167870484	Missense_Mutation	novel	A134S	0.85
LUSC	chr6	167825687	5'Flank	novel		0.06
LUSC	chr6	167826097	5'Flank	novel		0.44
LUSC	chr6	167826422	5'Flank	novel		0.09
LUSC	chr6	167951230	Nonsense_Mutation	novel	Y1285*	0.15
LUSC	chr6	167915350	Nonsense_Mutation	novel	Q821*	0.31
LUSC	chr6	167951352	Missense_Mutation	novel	S1326F	0.11
LUSC	chr6	167898406	Missense_Mutation	novel	A507S	0.3
LUSC	chr6	167898365	Missense_Mutation	rs756833549	A493V	0.09
LUSC	chr6	167969189	Missense_Mutation	rs759403576	R1771H	0.17
LUSC	chr6	167946718	Missense_Mutation	rs756198307	R1117C	0.14
LUSC	chr6	167917226	Silent	rs373339327	I894I	0.33
LUSC	chr6	167969828	Missense_Mutation	novel	T1790P	0.28
LUSC	chr6	167952025	Missense_Mutation	NA	S1550R	0.24
LUSC	chr6	167948423	Missense_Mutation	novel	Y1252C	0.22
LUSC	chr6	167826222	5'Flank	novel		0.36
LUSC	chr6	167951295	Missense_Mutation	novel	N1307S	0.27
LUSC	chr6	167880517	Splice_Region	novel	R299R	0.21
LUSC	chr6	167917140	Missense_Mutation	novel	I866V	0.06
LUSC	chr6	167948308	Missense_Mutation	novel	P1214S	0.28
LUSC	chr6	167911307	Missense_Mutation	NA	I619V	0.36
LUSC	chr6	167872343	Missense_Mutation	novel	D182N	0.06
LUSC	chr6	167952019	Silent	NA	D1548D	0.36
LUSC	chr6	167962640	Intron	novel		0.08
LUSC	chr6	167880418	Frame_Shift_Ins	novel	*L267Cfs17**	0.05
LUSC	chr6	167826240	5'Flank	novel		0.29
LUSC	chr6	167826222	5'Flank	novel		0.24
LUSC	chr6	167826476	5'Flank	rs754269094		0.2
LUSC	chr6	167875468	Missense_Mutation	rs761986153	R238W	0.6
LUSC	chr6	167952151	Silent	novel	L1592L	0.29
LUSC	chr6	167898466	Nonsense_Mutation	novel	G527*	0.27
LUSC	chr6	167962506	Missense_Mutation	novel	R1629K	0.15
LUSC	chr6	167918734	Splice_Site	novel	X897_splice	0.62
MESO	chr6	167976781	3'Flank	novel		0.23
OV	chr6	167951678	Nonsense_Mutation	NA	R1435*	0.85
OV	chr6	167872251	Frame_Shift_Ins	novel	*E151Dfs32**	0.03
OV	chr6	167872253	In_Frame_Ins	novel	G152delinsANTKKVKNAW	0.03
OV	chr6	167947935	Silent	novel	L1205L	0.06
OV	chr6	167911598	Intron	novel		0.19
OV	chr6	167826013	5'Flank	novel		0.38
OV	chr6	167890968	Silent	novel	G372G	0.11
OV	chr6	167951453	Missense_Mutation	NA	I1360V	0.17
OV	chr6	167826073	5'Flank	novel		0.22
OV	chr6	167826245	5'Flank	novel		0.75
OV	chr6	167898465	Frame_Shift_Ins	NA		0.94
OV	chr6	167965908	Missense_Mutation	novel	A1700G	0.32
PAAD	chr6	167825935	5'Flank	novel		0.18
PAAD	chr6	167898322	Nonsense_Mutation	novel	E479*	0.05
PAAD	chr6	167911326	Missense_Mutation	novel	S625I	0.16
PAAD	chr6	167951323	Silent	novel	T1316T	0.2
PAAD	chr6	167962520	Missense_Mutation	rs781720897	R1634C	0.17
PAAD	chr6	167898412	Frame_Shift_Del	novel	*A509Qfs9**	0.15
PCPG	chr6	167880512	Missense_Mutation	rs764123133	A298S	0.25
PRAD	chr6	167826244	5'Flank	NA		0.09
PRAD	chr6	167907230	Frame_Shift_Del	novel	*M571Rfs16**	0.2
PRAD	chr6	167896973	Splice_Site	NA	X439_splice	0.17
PRAD	chr6	167951825	Nonsense_Mutation	novel	Q1484*	0.14
PRAD	chr6	167880512	Missense_Mutation	NA	A298T	0.35
PRAD	chr6	167914259	Missense_Mutation	rs149079362	R710Q	0.3
PRAD	chr6	167915347	Missense_Mutation	rs780592632	R820C	0.34
READ	chr6	167914702	Missense_Mutation	novel	D748N	0.26
READ	chr6	167864576	Missense_Mutation	NA	R44I	0.23
READ	chr6	167947910	Missense_Mutation	novel	I1197T	0.16
READ	chr6	167826413	5'Flank	rs767234073		0.14
READ	chr6	167976781	3'Flank	novel		0.39
READ	chr6	167976073	3'Flank	novel		0.4
READ	chr6	167952012	Missense_Mutation	NA	K1546R	0.16
READ	chr6	167889219	Missense_Mutation	novel	M301R	0.07
READ	chr6	167962817	Intron	rs555153803		0.36
READ	chr6	167951896	Silent	NA	S1507S	0.29
READ	chr6	167825727	5'Flank	novel		0.06
READ	chr6	167864662	Missense_Mutation	rs747022102	E73K	0.43
READ	chr6	167875468	Missense_Mutation	rs761986153	R238W	0.41
READ	chr6	167911115	Missense_Mutation	novel	S595Y	0.39
READ	chr6	167911441	Silent	novel	V663V	0.48
READ	chr6	167915302	Missense_Mutation	novel	D805Y	0.08
READ	chr6	167951213	Nonsense_Mutation	NA	R1280*	0.33
READ	chr6	167870453	Missense_Mutation	novel	E123D	0.34
READ	chr6	167875394	Missense_Mutation	rs770737214	R213Q	0.19
SARC	chr6	167965912	Silent	novel	P1701P	0.36
SARC	chr6	167951891	Missense_Mutation	novel	S1506T	0.4
SKCM	chr6	167826511	5'Flank	novel		0.21
SKCM	chr6	167911421	Missense_Mutation	novel	T657A	0.38
SKCM	chr6	167969173	Missense_Mutation	novel	D1766N	0.46
SKCM	chr6	167918777	Missense_Mutation	novel	D911N	0.32
SKCM	chr6	167864683	Nonsense_Mutation	rs778113186	R80*	0.45
SKCM	chr6	167889224	Missense_Mutation	NA	P303S	0.46
SKCM	chr6	167951895	Missense_Mutation	rs796364513	S1507L	0.32
SKCM	chr6	167872270	Silent	NA	F157F	0.46
SKCM	chr6	167951699	Missense_Mutation	novel	G1442S	0.39
SKCM	chr6	167826377	5'Flank	novel		0.19
SKCM	chr6	167898246	Silent	novel	T453T	0.27
SKCM	chr6	167951512	Silent	rs114383783	F1379F	0.35
SKCM	chr6	167947928	Missense_Mutation	NA	G1203E	0.41
SKCM	chr6	167947890	Silent	NA	A1190A	0.55
SKCM	chr6	167918738	Missense_Mutation	NA	L898F	0.72
SKCM	chr6	167946901	Missense_Mutation	NA	N1178D	0.88
SKCM	chr6	167925023	Missense_Mutation	NA	E1004K	0.29
SKCM	chr6	167911336	Silent	NA	V628V	0.18
SKCM	chr6	167864653	Missense_Mutation	NA	D70N	0.16
SKCM	chr6	167880474	Missense_Mutation	NA	Y285F	0.33
SKCM	chr6	167864683	Nonsense_Mutation	rs778113186	R80*	0.15
SKCM	chr6	167914269	Silent	novel	L713L	0.16
SKCM	chr6	167896954	Silent	NA	L433L	0.1
SKCM	chr6	167951199	Missense_Mutation	NA	S1275F	0.41
SKCM	chr6	167825809	5'Flank	novel		0.25
SKCM	chr6	167951549	Missense_Mutation	NA	P1392S	0.1
SKCM	chr6	167951932	Silent	NA	D1519D	0.32
SKCM	chr6	167952086	Nonsense_Mutation	NA	Q1571*	0.3
SKCM	chr6	167951714	Nonsense_Mutation	NA	Q1447*	0.48
SKCM	chr6	167951569	Silent	rs773812168	G1398G	0.52
SKCM	chr6	167951742	Missense_Mutation	novel	P1456L	0.31
SKCM	chr6	167951935	Silent	NA	A1520A	0.19
SKCM	chr6	167951258	Missense_Mutation	novel	A1295T	0.21
STAD	chr6	167915212	Missense_Mutation	rs756328633	R775C	0.17
STAD	chr6	167925085	Silent	NA	A1024A	0.09
STAD	chr6	167864695	Nonsense_Mutation	NA	R84*	0.18
STAD	chr6	167872331	Nonsense_Mutation	NA	R178*	0.28
STAD	chr6	167918777	Missense_Mutation	novel	D911N	0.16
STAD	chr6	167870449	Missense_Mutation	rs770826881	R122Q	0.33
STAD	chr6	167951308	Silent	novel	S1311S	0.41
STAD	chr6	167952161	Missense_Mutation	NA	R1596C	0.33
STAD	chr6	167825733	5'Flank	novel		0.3
STAD	chr6	167826061	5'Flank	rs774725716		0.45
STAD	chr6	167870484	Missense_Mutation	rs769754520	A134T	0.38
STAD	chr6	167925049	Frame_Shift_Del	NA	*K1014Sfs20**	0.4
STAD	chr6	167893862	Missense_Mutation	NA	G393E	0.43
STAD	chr6	167952238	Intron	novel		0.34
STAD	chr6	167826396	5'Flank	novel		0.23
STAD	chr6	167962556	Missense_Mutation	rs150601242	A1646T	0.25
STAD	chr6	167918789	Missense_Mutation	rs779343002	R915C	0.21
STAD	chr6	167922907	Missense_Mutation	NA	Y980C	0.17
STAD	chr6	167914246	Nonsense_Mutation	novel	R706*	0.37
STAD	chr6	167969875	Frame_Shift_Ins	novel	*N1806Kfs2**	0.35
STAD	chr6	167951646	Missense_Mutation	NA	A1424V	0.19
STAD	chr6	167864702	Missense_Mutation	NA	L86Q	0.2
STAD	chr6	167951743	Silent	NA	P1456P	0.25
STAD	chr6	167969876	Missense_Mutation	rs771118698	N1806D	0.23
STAD	chr6	167864728	Missense_Mutation	NA	E95Q	0.12
STAD	chr6	167951187	Missense_Mutation	rs151265223	R1271H	0.26
STAD	chr6	167872302	Frame_Shift_Del	NA	*K170Rfs53**	0.24
STAD	chr6	167925049	Frame_Shift_Del	NA	*K1014Sfs20**	0.1
STAD	chr6	167880438	Missense_Mutation	NA	P273H	0.27
STAD	chr6	167911391	Missense_Mutation	NA	S647P	0.21
STAD	chr6	167943408	Missense_Mutation	NA	R1051C	0.04
STAD	chr6	167952048	Missense_Mutation	NA	R1558H	0.31
STAD	chr6	167922874	Missense_Mutation	rs768531974	P969L	0.52
TGCT	chr6	167965848	Frame_Shift_Del	novel	*G1682Sfs49**	0.23
TGCT	chr6	167875354	Missense_Mutation	novel	A200T	0.11
THCA	chr6	167951714	Missense_Mutation	NA	Q1447E	0.07
THCA	chr6	167872246	Frame_Shift_Ins	novel	*K150Gfs4**	0.09
THCA	chr6	167826570	5'Flank	novel		0.22
THYM	chr6	167966012	In_Frame_Del	rs758996773	E1740del	0.12
THYM	chr6	167918873	Missense_Mutation	novel	D943N	0.18
UCEC	chr6	167875363	Missense_Mutation	NA	Y203D	0.34
UCEC	chr6	167902329	Missense_Mutation	NA	E531D	0.28
UCEC	chr6	167951734	Silent	rs201083573	P1453P	0.47
UCEC	chr6	167946834	Missense_Mutation	NA	K1155N	0.26
UCEC	chr6	167825794	5'Flank	novel		0.15
UCEC	chr6	167872331	Nonsense_Mutation	NA	R178*	0.4
UCEC	chr6	167911424	Nonsense_Mutation	novel	E658*	0.27
UCEC	chr6	167917129	Missense_Mutation	rs111563192	D862G	0.15
UCEC	chr6	167962526	Missense_Mutation	rs368769724	R1636W	0.43
UCEC	chr6	167864696	Missense_Mutation	NA	R84Q	0.37
UCEC	chr6	167943166	Nonsense_Mutation	NA	S1039*	0.25
UCEC	chr6	167893892	Missense_Mutation	rs772507883	Y403C	0.36
UCEC	chr6	167915193	Silent	novel	G768G	0.27
UCEC	chr6	167943422	Silent	novel	G1055G	0.44
UCEC	chr6	167925049	Frame_Shift_Del	NA	*K1014Sfs20**	0.29
UCEC	chr6	167951708	Missense_Mutation	rs775819918	R1445C	0.09
UCEC	chr6	167826061	5'Flank	rs774725716		0.41
UCEC	chr6	167969840	Missense_Mutation	novel	R1794C	0.23
UCEC	chr6	167943448	Missense_Mutation	rs765967945	R1064Q	0.44
UCEC	chr6	167962670	Intron	novel		0.4
UCEC	chr6	167870426	Silent	NA	Q114Q	0.49
UCEC	chr6	167925070	Silent	novel	G1019G	0.42
UCEC	chr6	167947938	Silent	novel	C1206C	0.29
UCEC	chr6	167952180	Missense_Mutation	novel	R1602I	0.24
UCEC	chr6	167952106	Silent	novel	D1577D	0.44
UCEC	chr6	167918744	Nonsense_Mutation	novel	E900*	0.28
UCEC	chr6	167951528	Missense_Mutation	rs754140439	D1385N	0.35
UCEC	chr6	167952171	Missense_Mutation	novel	A1599D	0.29
UCEC	chr6	167969802	Missense_Mutation	novel	G1781E	0.38
UCEC	chr6	167946773	Nonsense_Mutation	novel	S1135*	0.19
UCEC	chr6	167948389	Missense_Mutation	rs372686576	R1241W	0.12
UCEC	chr6	167951768	Missense_Mutation	novel	E1465K	0.26
UCEC	chr6	167875377	Silent	rs140639514	P207P	0.42
UCEC	chr6	167870385	Splice_Site	NA	X101_splice	0.26
UCEC	chr6	167914647	Nonsense_Mutation	novel	Y729*	0.05
UCEC	chr6	167943155	Silent	NA	I1035I	0.22
UCEC	chr6	167975984	3'Flank	novel		0.17
UCEC	chr6	167890994	Missense_Mutation	rs200779172	P381L	0.41
UCEC	chr6	167864673	Silent	rs758827842	A76A	0.06
UCEC	chr6	167826084	5'Flank	novel		0.29
UCEC	chr6	167826664	5'Flank	novel		0.31
UCEC	chr6	167864627	Missense_Mutation	novel	R61Q	0.19
UCEC	chr6	167948327	Missense_Mutation	novel	P1220L	0.1
UCEC	chr6	167951595	Missense_Mutation	novel	A1407D	0.17
UCEC	chr6	167952130	Silent	rs138409874	D1585D	0.14
UCEC	chr6	167962524	Missense_Mutation	novel	R1635Q	0.14
UCEC	chr6	167872331	Nonsense_Mutation	NA	R178*	0.3
UCEC	chr6	167943166	Missense_Mutation	rs375077108	S1039L	0.53
UCEC	chr6	167947907	Missense_Mutation	NA	K1196R	0.35
UCEC	chr6	167951241	Missense_Mutation	rs200475003	R1289Q	0.34
UCEC	chr6	167951586	Missense_Mutation	NA	V1404A	0.23
UCEC	chr6	167946737	Missense_Mutation	rs755200405	R1123Q	0.12
UCEC	chr6	167898438	Silent	NA	L517L	0.16
UCEC	chr6	167976415	3'Flank	novel		0.13
UCEC	chr6	167911575	Intron	novel		0.44
UCEC	chr6	167976017	3'Flank	novel		0.75
UCEC	chr6	167864661	Silent	rs765753006	I72I	0.41
UCEC	chr6	167913607	Intron	novel		0.38
UCEC	chr6	167976008	3'Flank	novel		0.2
UCEC	chr6	167826399	5'Flank	rs765062513		0.28
UCEC	chr6	167870484	Missense_Mutation	rs769754520	A134T	0.3
UCEC	chr6	167911450	Silent	rs760584936	V666V	0.34
UCEC	chr6	167951195	Missense_Mutation	rs768477295	R1274C	0.39
UCEC	chr6	167962478	Missense_Mutation	NA	R1620C	0.39
UCEC	chr6	167976031	3'Flank	novel		0.48
UCEC	chr6	167976737	3'Flank	novel		0.45
UCEC	chr6	167864626	Missense_Mutation	rs770846848	R61W	0.32
UCEC	chr6	167914669	Nonsense_Mutation	novel	E737*	0.34
UCEC	chr6	167971860	3'Flank	novel		0.56
UCEC	chr6	167864667	Silent	rs373834830	T74T	0.41
UCEC	chr6	167890953	Missense_Mutation	novel	K367N	0.35
UCEC	chr6	167911386	Missense_Mutation	rs754471752	V645A	0.37
UCEC	chr6	167969188	Missense_Mutation	rs529414934	R1771C	0.34
UCEC	chr6	167948449	Missense_Mutation	novel	D1261Y	0.41
UCEC	chr6	167962621	Intron	rs749514065		0.45
UCEC	chr6	167964885	Intron	novel		0.45
UCEC	chr6	167826580	5'Flank	novel		0.41
UCEC	chr6	167971832	3'Flank	novel		0.4
UCEC	chr6	167925012	Missense_Mutation	novel	P1000H	0.31
UCEC	chr6	167951971	Silent	NA	I1532I	0.3
UCEC	chr6	167964783	Intron	novel		0.86
UCEC	chr6	167976694	3'Flank	rs371847911		0.51
UCEC	chr6	167946732	Silent	novel	K1121K	0.33
UCEC	chr6	167864662	Missense_Mutation	rs747022102	E73K	0.42
UCEC	chr6	167946835	Nonsense_Mutation	novel	K1156*	0.11
UCEC	chr6	167951207	Nonsense_Mutation	novel	E1278*	0.13
UCEC	chr6	167965966	Silent	novel	V1719V	0.19
UCEC	chr6	167889263	Nonsense_Mutation	novel	E316*	0.24
UCEC	chr6	167971719	3'Flank	novel		0.3
UCEC	chr6	167889253	Silent	NA	K312K	0.05
UCEC	chr6	167914293	Silent	novel	H721H	0.37
UCEC	chr6	167922936	In_Frame_Del	NA	L991del	0.37
UCEC	chr6	167969163	Silent	rs376394053	D1762D	0.39
UCEC	chr6	167976012	3'Flank	rs557858701		0.19
UCEC	chr6	167875394	Missense_Mutation	rs770737214	R213Q	0.45
UCEC	chr6	167898351	Missense_Mutation	novel	K488N	0.39
UCEC	chr6	167952093	Missense_Mutation	novel	S1573L	0.35
UCEC	chr6	167870483	Silent	rs376282690	D133D	0.45
UCEC	chr6	167911298	Missense_Mutation	novel	L616V	0.33
UCEC	chr6	167951512	Silent	rs114383783	F1379F	0.2
UCEC	chr6	167976748	3'Flank	novel		0.41
UCEC	chr6	167969802	Missense_Mutation	novel	G1781V	0.08
UCEC	chr6	167825578	5'Flank	novel		0.57
UCEC	chr6	167896922	Missense_Mutation	novel	L423V	0.21
UCEC	chr6	167898273	Silent	rs756963164	T462T	0.42
UCEC	chr6	167952183	Missense_Mutation	rs759940319	A1603V	0.32
UCEC	chr6	167969999	3'Flank	novel		0.58
UCEC	chr6	167976762	3'Flank	novel		0.25
UCEC	chr6	167864734	Missense_Mutation	NA	H97Y	0.35
UCEC	chr6	167911380	Missense_Mutation	rs753394042	R643Q	0.28
UCEC	chr6	167962478	Missense_Mutation	NA	R1620C	0.06
UCEC	chr6	167826262	5'Flank	novel		0.34
UCEC	chr6	167962803	Intron	novel		0.29
UCEC	chr6	167971879	3'Flank	novel		0.41
UCEC	chr6	167951998	Silent	novel	Q1541Q	0.33
UCEC	chr6	167952118	Missense_Mutation	novel	E1581D	0.12
UCEC	chr6	167962793	Intron	novel		0.11
UCEC	chr6	167925049	Frame_Shift_Del	NA	*K1014Sfs20**	0.18
UCEC	chr6	167951711	Missense_Mutation	NA	T1446A	0.28
UCEC	chr6	167962555	Silent	rs764768550	D1645D	0.25
UCEC	chr6	167864747	Splice_Site	NA	X101_splice	0.38
UCEC	chr6	167917139	Silent	NA	N865N	0.46
UCEC	chr6	167962551	Missense_Mutation	NA	R1644L	0.35
UCEC	chr6	167969170	Missense_Mutation	rs540701101	R1765W	0.27
UCEC	chr6	167914142	Intron	novel		0.37
UCEC	chr6	167962616	Intron	rs374360014		0.27
UCEC	chr6	167880419	Missense_Mutation	novel	L267M	0.08
UCEC	chr6	167946718	Missense_Mutation	rs756198307	R1117C	0.38
UCEC	chr6	167951612	Missense_Mutation	NA	E1413Q	0.08
UCEC	chr6	167917217	Missense_Mutation	novel	E891D	0.26
UCEC	chr6	167943970	Missense_Mutation	novel	S1083Y	0.34
UCEC	chr6	167947862	Missense_Mutation	novel	P1181L	0.25
UCEC	chr6	167948348	Missense_Mutation	novel	T1227I	0.25
UCEC	chr6	167962550	Nonsense_Mutation	novel	R1644*	0.59
UCEC	chr6	167825614	5'Flank	novel		0.4
UCEC	chr6	167825645	5'Flank	novel		0.47
UCEC	chr6	167952193	Splice_Region	novel		0.31
UCEC	chr6	167911348	Silent	NA	L632L	0.22
UCEC	chr6	167951186	Missense_Mutation	rs144621028	R1271C	0.09
UCEC	chr6	167962478	Missense_Mutation	NA	R1620C	0.37
UCEC	chr6	167825783	5'Flank	novel		0.5
UCEC	chr6	167969928	Missense_Mutation	novel	T1823I	0.05
UCEC	chr6	167875443	Missense_Mutation	novel	K229N	0.39
UCEC	chr6	167896964	Missense_Mutation	novel	S437A	0.21
UCEC	chr6	167915209	Nonsense_Mutation	rs750660726	R774*	0.33
UCEC	chr6	167915352	Silent	novel	Q821Q	0.11
UCEC	chr6	167943447	Nonsense_Mutation	novel	R1064*	0.59
UCEC	chr6	167962550	Nonsense_Mutation	novel	R1644*	0.38
UCEC	chr6	167971858	3'Flank	novel		0.38
UCEC	chr6	167864661	Silent	rs765753006	I72I	0.45
UCEC	chr6	167969842	Silent	novel	R1794R	0.12
UCEC	chr6	167976895	3'Flank	novel		0.47
UCS	chr6	167944042	Missense_Mutation	novel	S1107C	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2	0.041315
BLCA	DEL	0.3799	0.00027473
BRCA	DEL	0.3019	3.2026e-22
CESC	DEL	0.3017	9.8477e-05
KIRC	DEL	0.2443	7.439e-11
KIRP	DEL	0.1076	0.054498
LGG	DEL	0.1442	0.0022414
MESO	DEL	0.3448	0.0023534
OV	DEL	0.639	8.6228e-38
PAAD	DEL	0.375	0.11274
SKCM	DEL	0.5368	1.5442e-06
THYM	DEL	0.1382	0.10691

Survival Analysis

Cancer	P-value	Q-value
THYM	0.031	Kaplan-Meier Survival Analysis
KIRC	0.005	Kaplan-Meier Survival Analysis
STAD	0.027	Kaplan-Meier Survival Analysis
SARC	0.047	Kaplan-Meier Survival Analysis
MESO	0.0068	Kaplan-Meier Survival Analysis
SKCM	0.018	Kaplan-Meier Survival Analysis
PRAD	0.043	Kaplan-Meier Survival Analysis
BRCA	0.0044	Kaplan-Meier Survival Analysis
CESC	0.003	Kaplan-Meier Survival Analysis
READ	0.0046	Kaplan-Meier Survival Analysis
LAML	0.02	Kaplan-Meier Survival Analysis
LGG	0.021	Kaplan-Meier Survival Analysis
LUAD	0.026	Kaplan-Meier Survival Analysis
OV	0.00059	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130396 (Gene tree)
Gene ID: 4301
Gene Symbol: AFDN
Alias: AF-6|AF6|MLLT4
Full Name: afadin, adherens junction formation factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 145,102 bases
Position: chr6:167,826,922-167,972,023
Accession: 7137
RBP type: non-canonical RBP
Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000366806	AFDN-203	5962	-	ENSP00000355771	1781 (aa)	-	A8MQ02
ENST00000486649	AFDN-214	423	-	-	- (aa)	-	-
ENST00000366809	AFDN-204	4839	-	-	- (aa)	-	-
ENST00000511503	AFDN-220	1257	-	-	- (aa)	-	-
ENST00000497596	AFDN-215	728	-	ENSP00000426462	167 (aa)	-	H0YA98
ENST00000392112	AFDN-206	7459	XM_006715494	ENSP00000375960	1743 (aa)	XP_006715557	P55196
ENST00000485634	AFDN-213	606	-	ENSP00000423035	191 (aa)	-	H0Y948
ENST00000447894	AFDN-211	5475	XM_005266996	ENSP00000404595	1824 (aa)	XP_005267053	P55196
ENST00000351017	AFDN-202	5823	XM_006715491	ENSP00000252692	1831 (aa)	XP_006715554	J3KN01
ENST00000515794	AFDN-222	746	-	ENSP00000422166	124 (aa)	-	H0Y8U8
ENST00000400822	AFDN-207	7593	-	ENSP00000383623	1834 (aa)	-	P55196
ENST00000509296	AFDN-219	686	-	-	- (aa)	-	-
ENST00000400824	AFDN-208	875	-	ENSP00000383625	247 (aa)	-	F8W9I4
ENST00000511637	AFDN-221	5999	-	-	- (aa)	-	-
ENST00000400825	AFDN-209	963	-	ENSP00000383626	250 (aa)	-	E9PFY5
ENST00000507679	AFDN-217	670	-	-	- (aa)	-	-
ENST00000476946	AFDN-212	867	-	ENSP00000424188	129 (aa)	-	H0Y9I0
ENST00000392108	AFDN-205	6812	-	ENSP00000375956	1651 (aa)	-	P55196
ENST00000507704	AFDN-218	1031	-	ENSP00000421441	313 (aa)	-	H0Y8L4
ENST00000503021	AFDN-216	581	-	-	- (aa)	-	-
ENST00000423229	AFDN-210	1807	-	ENSP00000414675	389 (aa)	-	H0Y7R8
ENST00000344191	AFDN-201	5249	-	ENSP00000341118	1665 (aa)	-	Q5TIG5

Gene Model

Click here to download ENSG00000130396's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04014	Ras signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04520	Adherens junction	KEGG
hsa04530	Tight junction	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130396	Fibrinogen	1.0580000E-005	-
ENSG00000130396	Fibrinogen	2.0590000E-007	-
ENSG00000130396	Platelet Function Tests	7.2200000E-006	-
ENSG00000130396	Platelet Function Tests	9.4600000E-006	-
ENSG00000130396	Platelet Function Tests	5.8900000E-007	-
ENSG00000130396	Platelet Function Tests	1.0500000E-006	-
ENSG00000130396	Platelet Function Tests	6.1000000E-007	-
ENSG00000130396	Platelet Function Tests	1.1700000E-007	-
ENSG00000130396	Platelet Function Tests	3.9900000E-006	-
ENSG00000130396	Platelet Function Tests	2.9000000E-006	-
ENSG00000130396	Platelet Function Tests	1.4700000E-007	-
ENSG00000130396	Platelet Function Tests	3.4600000E-008	-
ENSG00000130396	Platelet Function Tests	3.5600000E-006	-
ENSG00000130396	Child Development Disorders, Pervasive	6.1424800E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130396	rs62427705	6	167886940	?	Non-albumin protein levels	29403010	[0.023-0.046] unit increase novel	0.03439	EFO_0004568
ENSG00000130396	rs3800533	6	167935400	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000130396	rs2285248	6	167942931	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130396's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130396	AFDN	100	96.761	ENSMUSG00000068036	Afdn	100	96.943	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	17491594.22891260.23750010.23885123.27815408.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005911	cell-cell junction	10856295.	TAS	Component
GO:0005913	cell-cell adherens junction	21873635.	IBA	Component
GO:0007155	cell adhesion	10856295.	TAS	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0007267	cell-cell signaling	8242616.	TAS	Process
GO:0008022	protein C-terminus binding	10856295.	TAS	Function
GO:0010628	positive regulation of gene expression	25893857.	IMP	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0017016	Ras GTPase binding	23885123.	IPI	Function
GO:0022409	positive regulation of cell-cell adhesion	25893857.	IMP	Process
GO:0030054	cell junction	-	IDA	Component
GO:0030336	negative regulation of cell migration	21478912.	IMP	Process
GO:0032880	regulation of protein localization	21873635.	IBA	Process
GO:0034332	adherens junction organization	-	TAS	Process
GO:0043547	positive regulation of GTPase activity	23885123.	IMP	Process
GO:0044291	cell-cell contact zone	16882694.	IDA	Component
GO:0044331	cell-cell adhesion mediated by cadherin	23990464.	ISS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0050839	cell adhesion molecule binding	21873635.	IBA	Function
GO:0051015	actin filament binding	16882694.	IDA	Function
GO:0061951	establishment of protein localization to plasma membrane	23990464.	ISS	Process
GO:0070160	tight junction	27815408.	IDA	Component
GO:0070830	bicellular tight junction assembly	27815408.	IMP	Process
GO:0090557	establishment of endothelial intestinal barrier	23885123.	IMP	Process
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	16882694.	IMP	Process

EuRBPDB

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Eesembl ID

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.