EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26411419	PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway.	Diagn Pathol	2015 Sep 28	Shu XR	doi: 10.1186/s13000-015-0404-z.
22710715	p21-Activated kinase 4 promotes prostate cancer progression through CREB.	Oncogene	2013 May 9	Park MH	doi: 10.1038/onc.2012.255
22766504	MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells.	Biochem Biophys Res Commun	2012 Oct 26	Wang Z	doi: 10.1016/j.bbrc.2012.06.123
28393218	P21 activated kinase 4 binds translation elongation factor eEF1A1 to promote gastric cancer cell migration and invasion.	Oncol Rep	2017 May	Li X	doi: 10.3892/or.2017.5543
28542136	PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth.	Cell Death Dis	2017 May 25	Zhang X	doi: 10.1038/cddis.2017.85.
30177834	A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ERα-positive breast cancer cells.	Oncogene	2019 Feb	Li Y	doi: 10.1038/s41388-018-0456-0
20406887	PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.	J Cell Sci	2010 May 15	Wells CM	doi: 10.1242/jcs.055707
20501374	[Expression of PAK4 in breast cancer and benign breast pathological changes].	Nan Fang Yi Ke Da Xue Xue Bao	2010 May	Yang JX	-
26546043	p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling.	Cancer Lett	2016 Jan 28	Tyagi N	doi: 10.1016/j.canlet.2015.10.028
22085492	LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells.	Cancer Lett	2012 Apr 1	Zhang J	doi: 10.1016/j.canlet.2011.11.007
26124003	Activated Pak4 expression correlates with poor prognosis in human gastric cancer patients.	Tumour Biol	2015 Dec	Li D	doi: 10.1007/s13277-015-3368-4
19778628	DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.	Int J Biochem Cell Biol	2010 Jan	Li X	doi: 10.1016/j.biocel.2009.09.008
23893240	PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.	Oncogene	2014 Jun 19	Guo Q	doi: 10.1038/onc.2013.296
25791829	P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration.	J Surg Res	2015 Jun 1	Song B	doi: 10.1016/j.jss.2015.02.035
27297086	Study on the expression of PAK4 and P54 protein in breast cancer.	World J Surg Oncol	2016 Jun 13	Bi Y	doi: 10.1186/s12957-016-0913-6.
26218748	p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.	PLoS One	2015 Jul 28	Siu MK	doi: 10.1371/journal.pone.0133467
26614788	Prognostic significance of PAK4 expression in gastric cancer.	J Clin Pathol	2016 Jul	Kobayashi K	doi: 10.1136/jclinpath-2015-203330
19050074	Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.	Proc Natl Acad Sci U S A	2008 Dec 9	Kimmelman AC	doi: 10.1073/pnas.0809966105
23934187	Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis.	Oncogene	2014 Jun 26	Wang C	doi: 10.1038/onc.2013.300
23790167	p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion.	Neoplasma	2013	Lu W	doi: 10.4149/neo_2013_064.
20926745	p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients.	Proc Natl Acad Sci U S A	2010 Oct 26	Siu MK	doi: 10.1073/pnas.0907481107
25238288	p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-??B pathway.	Oncotarget	2014 Sep 30	Tyagi N	-
28288786	p21-activated kinase 4 regulates HIF-1α translation in cancer cells.	Biochem Biophys Res Commun	2017 Apr 29	Kim H	doi: 10.1016/j.bbrc.2017.03.024
28407679	Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.	Oncotarget	2017 Mar 14	He LF	doi: 10.18632/oncotarget.7466.
28440035	MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway.	Cancer Med	2017 Jun	Sheng N	doi: 10.1002/cam4.1029
28178642	P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation.	Oncotarget	2017 Apr 11	Xie X	doi: 10.18632/oncotarget.15079.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	39178599	3'UTR	novel		0.45
BLCA	chr19	39169599	Missense_Mutation	NA	N16H	0.38
BLCA	chr19	39178635	3'UTR	novel		0.29
BRCA	chr19	39169588	Missense_Mutation	NA	S12F	0.29
BRCA	chr19	39169628	Silent	rs113813881	F25F	0.16
CESC	chr19	39173575	Splice_Site	novel	X223_splice	0.49
CESC	chr19	39178591	3'UTR	rs774636800		0.13
CESC	chr19	39169712	Silent	rs377525201	L53L	0.44
CESC	chr19	39173103	Silent	novel	G130G	0.56
CESC	chr19	39179272	3'UTR	novel		0.4
CESC	chr19	39173673	Missense_Mutation	rs764392821	R254Q	0.16
CESC	chr19	39177726	Frame_Shift_Del	NA	*Y515Tfs10**	0.26
CESC	chr19	39178489	Silent	rs55747949	T562T	0.43
CESC	chr19	39173649	Missense_Mutation	NA	S246F	0.37
CESC	chr19	39178599	3'UTR	novel		0.26
COAD	chr19	39178429	Silent	NA	S542S	0.38
COAD	chr19	39175365	Missense_Mutation	rs377696830	S429L	0.38
COAD	chr19	39177688	Missense_Mutation	rs774651046	S500L	0.39
COAD	chr19	39178429	Silent	NA	S542S	0.5
COAD	chr19	39175408	Silent	rs141004307	S443S	0.07
COAD	chr19	39178471	Silent	NA	D556D	0.13
COAD	chr19	39169566	Missense_Mutation	NA	R5G	0.25
COAD	chr19	39173142	Missense_Mutation	NA	E143D	0.32
COAD	chr19	39173273	Frame_Shift_Del	NA	*Q189Sfs180**	0.6
COAD	chr19	39173857	Silent	NA	G315G	0.36
COAD	chr19	39176617	Missense_Mutation	NA	A463T	0.16
COAD	chr19	39173273	Frame_Shift_Del	NA	*Q189Sfs180**	0.34
COAD	chr19	39173273	Frame_Shift_Del	NA	*Q189Sfs180**	0.38
COAD	chr19	39178560	Missense_Mutation	rs747655225	R586H	0.19
COAD	chr19	39173273	Frame_Shift_Del	NA	*Q189Sfs180**	0.44
COAD	chr19	39176663	Missense_Mutation	NA	T478M	0.1
COAD	chr19	39176641	Nonsense_Mutation	NA	R471*	0.08
COAD	chr19	39173037	Silent	rs55711468	P108P	0.33
COAD	chr19	39173034	Silent	NA	P107P	0.31
COAD	chr19	39169746	Frame_Shift_Del	NA	*A66Pfs29**	0.29
COAD	chr19	39177719	Silent	rs749356499	D510D	0.43
DLBC	chr19	39169652	Silent	rs757615009	T33T	0.21
ESCA	chr19	39173084	Missense_Mutation	novel	T124M	0.14
ESCA	chr19	39175000	Missense_Mutation	rs780200774	E390K	0.22
GBM	chr19	39175384	Silent	rs757293101	G435G	0.31
GBM	chr19	39174985	Missense_Mutation	NA	Y385H	0.32
GBM	chr19	39173339	Missense_Mutation	novel	P209L	0.1
HNSC	chr19	39169673	Silent	novel	Q40Q	0.43
HNSC	chr19	39169534	Splice_Region	rs376621337		0.23
HNSC	chr19	39173787	Missense_Mutation	novel	P292L	0.41
KIRC	chr19	39175377	Missense_Mutation	novel	A433V	0.33
KIRC	chr19	39177717	Missense_Mutation	NA	D510N	0.39
KIRC	chr19	39173852	Missense_Mutation	NA	P314T	0.2
KIRP	chr19	39176627	Missense_Mutation	NA	S466I	0.42
KIRP	chr19	39172930	Missense_Mutation	novel	G73R	0.38
LGG	chr19	39173635	Missense_Mutation	NA	Q241H	0.09
LIHC	chr19	39173617	Silent	novel	G235G	0.61
LIHC	chr19	39178632	3'UTR	novel		0.53
LIHC	chr19	39177701	Missense_Mutation	novel	M504I	0.34
LIHC	chr19	39172929	Silent	novel	R72R	0.41
LIHC	chr19	39175000	Nonsense_Mutation	novel	E390*	0.09
LIHC	chr19	39169576	Missense_Mutation	NA	R8Q	0.18
LUAD	chr19	39173320	Missense_Mutation	rs370979504	R203W	0.47
LUAD	chr19	39169721	Silent	rs764654285	P56P	0.29
LUAD	chr19	39178539	Missense_Mutation	novel	A579D	0.3
LUAD	chr19	39169617	Missense_Mutation	novel	H22Y	0.17
LUAD	chr19	39173365	Missense_Mutation	NA	R218W	0.17
LUAD	chr19	39174958	Missense_Mutation	rs375220515	E376K	0.42
LUAD	chr19	39175005	Silent	novel	L391L	0.2
LUAD	chr19	39176622	Missense_Mutation	novel	Q464H	0.26
LUAD	chr19	39169534	Splice_Region	rs376621337		0.36
LUSC	chr19	39169653	Missense_Mutation	novel	G34W	0.15
LUSC	chr19	39173993	Nonsense_Mutation	novel	E361*	0.35
LUSC	chr19	39178574	Nonsense_Mutation	NA	R591*	0.48
OV	chr19	39169631	Missense_Mutation	novel	D26E	0.21
OV	chr19	39178501	Silent	NA	L566L	0.33
PAAD	chr19	39176658	Silent	rs201757969	V476V	0.17
PAAD	chr19	39176673	Nonsense_Mutation	novel	W481*	0.21
READ	chr19	39173273	Frame_Shift_Del	NA	*Q189Sfs180**	0.19
SARC	chr19	39178685	3'UTR	novel		0.22
SKCM	chr19	39173595	Missense_Mutation	novel	A228G	0.35
SKCM	chr19	39173596	Silent	novel	A228A	0.32
SKCM	chr19	39169649	Silent	NA	F32F	0.24
SKCM	chr19	39178428	Missense_Mutation	NA	S542L	0.57
SKCM	chr19	39169713	Missense_Mutation	NA	V54F	0.36
SKCM	chr19	39176666	Missense_Mutation	NA	P479L	0.19
SKCM	chr19	39173687	Missense_Mutation	NA	P259S	0.44
SKCM	chr19	39177731	Silent	rs146955542	P514P	0.42
SKCM	chr19	39176678	Missense_Mutation	novel	A483V	0.27
SKCM	chr19	39176679	Silent	NA	A483A	0.27
SKCM	chr19	39178511	Missense_Mutation	novel	P570S	0.41
SKCM	chr19	39169544	5'UTR	rs775288678		0.33
SKCM	chr19	39169553	5'UTR	novel		0.13
SKCM	chr19	39176702	Missense_Mutation	NA	P491L	0.09
SKCM	chr19	39173665	Silent	novel	T251T	0.41
SKCM	chr19	39169744	Missense_Mutation	NA	P64L	0.43
STAD	chr19	39173991	Missense_Mutation	rs777017835	R360H	0.53
STAD	chr19	39176663	Missense_Mutation	NA	T478M	0.19
STAD	chr19	39176677	Missense_Mutation	rs780795083	A483T	0.43
STAD	chr19	39177725	Frame_Shift_Ins	rs769136911	*Y515Lfs124**	0.57
STAD	chr19	39176703	Silent	NA	P491P	0.32
STAD	chr19	39176680	Missense_Mutation	novel	P484S	0.4
STAD	chr19	39178533	Missense_Mutation	rs762977178	P577L	0.21
STAD	chr19	39178569	Missense_Mutation	NA	R589H	0.24
UCEC	chr19	39173034	Silent	NA	P107P	0.25
UCEC	chr19	39169535	5'UTR	rs370008929		0.44
UCEC	chr19	39169691	Silent	novel	S46S	0.33
UCEC	chr19	39179109	3'UTR	novel		0.36
UCEC	chr19	39169593	Missense_Mutation	novel	P14S	0.4
UCEC	chr19	39176657	Missense_Mutation	novel	V476D	0.44
UCEC	chr19	39177773	Silent	rs767808811	R528R	0.31
UCEC	chr19	39178991	3'UTR	rs757223909		0.39
UCEC	chr19	39179288	3'UTR	novel		0.46
UCEC	chr19	39179333	3'UTR	novel		0.23
UCEC	chr19	39178490	Missense_Mutation	novel	A563T	0.42
UCEC	chr19	39175324	Silent	NA	E415E	0.38
UCEC	chr19	39169629	Missense_Mutation	novel	D26N	0.09
UCEC	chr19	39172937	Missense_Mutation	novel	K75T	0.14
UCEC	chr19	39173042	Missense_Mutation	rs763084575	R110H	0.55
UCEC	chr19	39173151	Silent	rs761695934	G146G	0.69
UCEC	chr19	39175050	Silent	rs372653621	I406I	0.52
UCEC	chr19	39176651	Missense_Mutation	rs776546703	S474L	0.37
UCEC	chr19	39176651	Missense_Mutation	rs776546703	S474L	0.47
UCEC	chr19	39177675	Missense_Mutation	rs746034918	V496I	0.35
UCEC	chr19	39173126	Missense_Mutation	novel	F138S	0.28
UCEC	chr19	39175409	Missense_Mutation	rs760075494	D444N	0.32
UCEC	chr19	39172997	Missense_Mutation	novel	T95I	0.35
UCEC	chr19	39175324	Silent	NA	E415E	0.75
UCEC	chr19	39176709	Silent	novel	G493G	0.24
UCEC	chr19	39175428	Missense_Mutation	novel	H450R	0.22
UCEC	chr19	39173635	Silent	novel	Q241Q	0.25
UCS	chr19	39173628	Frame_Shift_Ins	novel	*Q241Pfs62**	0.55
UCS	chr19	39169688	Missense_Mutation	novel	E45D	0.71

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0451	0.054726
OV	AMP	0.3644	2.2539e-28
READ	DEL	0.0545	0.23023
UCS	DEL	0.125	0.12448

Survival Analysis

Cancer	P-value	Q-value
THYM	0.049	Kaplan-Meier Survival Analysis
MESO	0.038	Kaplan-Meier Survival Analysis
ACC	0.00062	Kaplan-Meier Survival Analysis
SKCM	0.00012	Kaplan-Meier Survival Analysis
PRAD	0.016	Kaplan-Meier Survival Analysis
TGCT	0.042	Kaplan-Meier Survival Analysis
KICH	0.0043	Kaplan-Meier Survival Analysis
UCEC	0.029	Kaplan-Meier Survival Analysis
LIHC	0.0099	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0028	Kaplan-Meier Survival Analysis
OV	0.048	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000130669 (Gene tree)
Gene ID: 10298
Gene Symbol: PAK4
Alias: N
Full Name: p21 (RAC1) activated kinase 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 57,047 bases
Position: chr19:39,125,770-39,182,816
Accession: 16059
RBP type: non-canonical RBP
Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000360442	PAK4-203	2855	-	ENSP00000353625	591 (aa)	-	O96013
ENST00000600350	PAK4-211	549	-	-	- (aa)	-	-
ENST00000602004	PAK4-212	564	-	ENSP00000471318	182 (aa)	-	M0R0L9
ENST00000593480	PAK4-204	714	-	ENSP00000472862	131 (aa)	-	M0R2X4
ENST00000593690	PAK4-205	3025	XM_011526316	ENSP00000469413	591 (aa)	XP_011524618	O96013
ENST00000599470	PAK4-209	1715	-	ENSP00000470284	438 (aa)	-	O96013
ENST00000597715	PAK4-206	633	-	ENSP00000472061	149 (aa)	-	M0R1R1
ENST00000599386	PAK4-208	5735	XM_011526320	ENSP00000471157	438 (aa)	XP_011524622	O96013
ENST00000321944	PAK4-201	2555	-	ENSP00000326864	501 (aa)	-	O96013
ENST00000599657	PAK4-210	534	-	ENSP00000473215	93 (aa)	-	M0R3G6
ENST00000358301	PAK4-202	2739	-	ENSP00000351049	591 (aa)	-	O96013
ENST00000597766	PAK4-207	380	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000130669's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04012	ErbB signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04360	Axon guidance	KEGG
hsa04510	Focal adhesion	KEGG
hsa04660	T cell receptor signaling pathway	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05211	Renal cell carcinoma	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130669's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001558	regulation of cell growth	20070256.	TAS	Process
GO:0004672	protein kinase activity	9822598.	NAS	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	26607847.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	21788589.	IMP	Function
GO:0005515	protein binding	20936779.21044950.22653441.24130170.25074804.26607847.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005794	Golgi apparatus	9822598.	TAS	Component
GO:0005913	cell-cell adherens junction	25468996.	HDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006915	apoptotic process	20070256.	TAS	Process
GO:0007010	cytoskeleton organization	20070256.	TAS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007165	signal transduction	20070256.	TAS	Process
GO:0008283	cell proliferation	20070256.	TAS	Process
GO:0016477	cell migration	21873635.	IBA	Process
GO:0016477	cell migration	20070256.	TAS	Process
GO:0023014	signal transduction by protein phosphorylation	21873635.	IBA	Process
GO:0031098	stress-activated protein kinase signaling cascade	21873635.	IBA	Process
GO:0032147	activation of protein kinase activity	21873635.	IBA	Process
GO:0043408	regulation of MAPK cascade	21873635.	IBA	Process
GO:0045766	positive regulation of angiogenesis	21788589.	IMP	Process
GO:0048365	Rac GTPase binding	21873635.	IBA	Function
GO:0060996	dendritic spine development	-	IEA	Process
GO:0071407	cellular response to organic cyclic compound	-	IEA	Process
GO:0098609	cell-cell adhesion	-	IEA	Process
GO:0098641	cadherin binding involved in cell-cell adhesion	25468996.	HDA	Function
GO:2000352	negative regulation of endothelial cell apoptotic process	21788589.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.