EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	26269477	Silent	novel	L504L	0.32
BLCA	chr1	26259717	Missense_Mutation	novel	S419F	0.17
BLCA	chr1	26277300	3'UTR	novel		0.14
BLCA	chr1	26259703	Missense_Mutation	NA	K414N	0.42
BLCA	chr1	26258212	Silent	novel	L369L	0.27
BLCA	chr1	26244224	Missense_Mutation	novel	I38M	0.48
BLCA	chr1	26244270	Missense_Mutation	rs369652785	D54N	0.19
BLCA	chr1	26257704	Silent	novel	L337L	0.17
BLCA	chr1	26257705	Nonsense_Mutation	novel	K338*	0.17
BLCA	chr1	26268583	Missense_Mutation	rs373834084	R481H	0.23
BRCA	chr1	26255467	Missense_Mutation	NA	G169R	0.21
BRCA	chr1	26257712	Missense_Mutation	NA	K340I	0.23
BRCA	chr1	26269506	Missense_Mutation	NA	T514S	0.12
BRCA	chr1	26255755	Nonsense_Mutation	NA	Q265*	0.46
BRCA	chr1	26258180	Nonsense_Mutation	rs143678426	R359*	0.19
BRCA	chr1	26255761	Missense_Mutation	NA	W267G	0.35
BRCA	chr1	26277147	Missense_Mutation	NA	E715Q	0.44
CESC	chr1	26277159	Missense_Mutation	NA	D719H	0.25
CESC	chr1	26258190	Frame_Shift_Ins	novel	*L363Rfs22**	0.08
CESC	chr1	26244252	Missense_Mutation	rs560353875	R48C	0.36
CESC	chr1	26278019	3'UTR	novel		0.38
COAD	chr1	26277448	3'UTR	novel		0.3
COAD	chr1	26244227	Silent	novel	S39S	0.45
COAD	chr1	26244256	Missense_Mutation	novel	C49Y	0.35
COAD	chr1	26255381	Missense_Mutation	NA	H140P	0.3
COAD	chr1	26259714	Missense_Mutation	novel	A418V	0.1
COAD	chr1	26255368	Missense_Mutation	rs141749569	G136S	0.25
COAD	chr1	26259789	Missense_Mutation	NA	K443T	0.12
DLBC	chr1	26275028	Missense_Mutation	novel	R620L	0.31
DLBC	chr1	26258189	Missense_Mutation	rs753729078	E362K	0.21
GBM	chr1	26255833	Missense_Mutation	novel	E291K	0.24
GBM	chr1	26258188	Silent	rs756120331	S361S	0.26
GBM	chr1	26272058	Missense_Mutation	rs773316750	R594H	0.3
HNSC	chr1	26255417	Missense_Mutation	novel	S152C	0.17
HNSC	chr1	26268515	Missense_Mutation	novel	L458F	0.17
HNSC	chr1	26269548	Missense_Mutation	novel	R528T	0.07
KIRC	chr1	26258194	Silent	NA	L363L	0.28
KIRP	chr1	26276587	Missense_Mutation	NA	H652L	0.61
LAML	chr1	26255802	Silent	novel	S280S	0.07
LAML	chr1	26255848	Missense_Mutation	novel	Q296E	0.34
LGG	chr1	26255535	Silent	novel	S191S	0.38
LGG	chr1	26271060	Nonsense_Mutation	novel	E566*	0.48
LIHC	chr1	26259760	Silent	rs534974823	A433A	0.31
LIHC	chr1	26276755	Missense_Mutation	novel	I708N	0.28
LIHC	chr1	26275057	Missense_Mutation	novel	T630A	0.65
LUAD	chr1	26259771	Missense_Mutation	novel	H437L	0.37
LUAD	chr1	26255853	Missense_Mutation	novel	M297I	0.13
LUAD	chr1	26255854	Nonsense_Mutation	novel	E298*	0.11
LUAD	chr1	26259640	Missense_Mutation	NA	F393L	0.07
LUAD	chr1	26277292	Silent	NA	*763*	0.12
LUAD	chr1	26277245	Missense_Mutation	novel	M747I	0.09
LUAD	chr1	26239794	Missense_Mutation	NA	Q4L	0.17
LUSC	chr1	26255515	Nonsense_Mutation	novel	E185*	0.22
LUSC	chr1	26269534	Silent	NA	T523T	0.21
LUSC	chr1	26255260	Missense_Mutation	NA	G100W	0.28
LUSC	chr1	26276671	Missense_Mutation	NA	C680S	0.38
MESO	chr1	26277237	Missense_Mutation	novel	T745P	0.42
OV	chr1	26277209	Frame_Shift_Del	novel	*Q735Hfs9**	0.06
OV	chr1	26277342	3'UTR	novel		0.17
PAAD	chr1	26255489	Missense_Mutation	rs756429210	A176V	0.14
PRAD	chr1	26277411	3'UTR	novel		0.29
PRAD	chr1	26255843	Missense_Mutation	rs764919627	R294H	0.48
PRAD	chr1	26277213	Missense_Mutation	rs779658026	R737C	0.41
READ	chr1	26259748	Silent	rs773036437	S429S	0.22
READ	chr1	26277273	Nonsense_Mutation	novel	E757*	0.4
SARC	chr1	26278244	3'UTR	novel		0.08
SKCM	chr1	26259701	Missense_Mutation	NA	K414E	0.39
SKCM	chr1	26255569	Missense_Mutation	novel	H203Y	0.3
SKCM	chr1	26271058	Missense_Mutation	NA	P565Q	0.08
SKCM	chr1	26271097	Missense_Mutation	rs747760374	S578L	0.92
SKCM	chr1	26255249	Missense_Mutation	NA	P96L	0.31
SKCM	chr1	26276582	Silent	NA	Q650Q	0.19
SKCM	chr1	26255353	Missense_Mutation	NA	R131G	0.41
SKCM	chr1	26255269	Missense_Mutation	novel	P103S	0.39
SKCM	chr1	26244193	Missense_Mutation	NA	S28F	0.33
SKCM	chr1	26244193	Missense_Mutation	NA	S28F	0.21
SKCM	chr1	26268492	Missense_Mutation	NA	R451C	0.36
SKCM	chr1	26257606	Missense_Mutation	novel	G305R	0.34
SKCM	chr1	26257607	Missense_Mutation	novel	G305E	0.34
SKCM	chr1	26244233	Silent	novel	P41P	0.61
SKCM	chr1	26255672	Missense_Mutation	rs779280111	R237Q	0.11
SKCM	chr1	26268492	Missense_Mutation	NA	R451C	0.22
STAD	chr1	26268632	Silent	novel	Q497Q	0.24
STAD	chr1	26268568	Missense_Mutation	novel	I476N	0.43
STAD	chr1	26257675	Missense_Mutation	NA	S328G	0.13
STAD	chr1	26276592	Missense_Mutation	rs772262341	R654C	0.27
STAD	chr1	26271079	Nonsense_Mutation	novel	W572*	0.41
STAD	chr1	26277377	3'UTR	novel		0.48
STAD	chr1	26239825	Silent	rs201779964	H14H	0.14
STAD	chr1	26255606	Missense_Mutation	NA	S215N	0.34
TGCT	chr1	26258142	Splice_Site	novel	X346_splice	0.16
THCA	chr1	26277359	3'UTR	novel		0.06
THCA	chr1	26259802	Missense_Mutation	novel	R447S	0.13
UCEC	chr1	26278174	3'UTR	novel		0.19
UCEC	chr1	26255404	Missense_Mutation	novel	L148I	0.22
UCEC	chr1	26255838	Missense_Mutation	NA	L292F	0.25
UCEC	chr1	26268599	Silent	NA	L486L	0.52
UCEC	chr1	26277784	3'UTR	novel		0.2
UCEC	chr1	26244170	Silent	rs755493447	S20S	0.17
UCEC	chr1	26277653	3'UTR	novel		0.41
UCEC	chr1	26255384	Missense_Mutation	novel	S141F	0.41
UCEC	chr1	26278591	3'UTR	novel		0.22
UCEC	chr1	26255368	Missense_Mutation	rs141749569	G136S	0.28
UCEC	chr1	26276621	Silent	NA	S663S	0.17
UCEC	chr1	26255277	Silent	NA	K105K	0.25
UCEC	chr1	26277421	3'UTR	novel		0.16
UCEC	chr1	26255515	Nonsense_Mutation	novel	E185*	0.18
UCEC	chr1	26269511	Silent	rs776360857	L516L	0.29
UCEC	chr1	26278439	3'UTR	rs761605314		0.32
UCEC	chr1	26277278	Missense_Mutation	novel	N758K	0.29
UCEC	chr1	26271093	Missense_Mutation	rs777194985	D577N	0.5
UCEC	chr1	26255636	Missense_Mutation	NA	A225V	0.16
UCEC	chr1	26257675	Missense_Mutation	NA	S328G	0.22
UCEC	chr1	26277910	3'UTR	novel		0.31
UCEC	chr1	26278577	3'UTR	novel		0.31
UCEC	chr1	26239770	5'UTR	novel		0.1
UCEC	chr1	26255801	Missense_Mutation	novel	S280Y	0.12
UCEC	chr1	26268526	Missense_Mutation	novel	C462Y	0.53
UCEC	chr1	26271087	Nonsense_Mutation	rs560358188	R575*	0.38
UCEC	chr1	26258180	Nonsense_Mutation	rs143678426	R359*	0.39
UCEC	chr1	26277623	3'UTR	novel		0.32
UCEC	chr1	26278651	3'UTR	rs556533146		0.44
UCEC	chr1	26277297	3'UTR	novel		0.59
UCEC	chr1	26278746	3'UTR	novel		0.18
UCEC	chr1	26258188	Silent	rs756120331	S361S	0.43
UCEC	chr1	26259703	Missense_Mutation	NA	K414N	0.36
UCEC	chr1	26244285	Missense_Mutation	novel	A59S	0.14
UCEC	chr1	26257696	Missense_Mutation	rs772525914	H335Y	0.2
UCEC	chr1	26278500	3'UTR	novel		0.1
UCEC	chr1	26278334	3'UTR	novel		0.49
UCEC	chr1	26278440	3'UTR	novel		0.39
UCEC	chr1	26278318	3'UTR	novel		0.13
UCEC	chr1	26268540	Missense_Mutation	NA	E467K	0.53
UCEC	chr1	26255285	Missense_Mutation	NA	S108Y	0.35
UCEC	chr1	26269487	Missense_Mutation	NA	E508K	0.48
UCEC	chr1	26268492	Missense_Mutation	NA	R451C	0.09
UCEC	chr1	26276561	Silent	novel	I643I	0.22
UCEC	chr1	26277259	Missense_Mutation	novel	A752V	0.25
UCEC	chr1	26277421	3'UTR	novel		0.28
UCEC	chr1	26255238	Silent	novel	A92A	0.37
UCEC	chr1	26278085	3'UTR	novel		0.47
UCEC	chr1	26278191	3'UTR	rs567724784		0.16
UCEC	chr1	26255660	Missense_Mutation	novel	A233V	0.42
UCEC	chr1	26277463	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0915	0.00029523
CHOL	DEL	0.7778	3.3987e-23
COAD	DEL	0.3259	4.7302e-24
DLBC	DEL	0.1042	0.011841
ESCA	DEL	0.2935	0.0012162
HNSC	DEL	0.136	7.0766e-07
KIRC	DEL	0.1496	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LIHC	DEL	0.3486	1.6679e-20
LUAD	DEL	0.1705	0.0024765
LUSC	DEL	0.3752	2.5882e-07
MESO	DEL	0.2644	2.434e-07
READ	DEL	0.4	2.1758e-10
TGCT	DEL	0.16	0.00046313

Survival Analysis

Cancer	P-value	Q-value
THYM	0.025	Kaplan-Meier Survival Analysis
STAD	0.019	Kaplan-Meier Survival Analysis
SARC	0.0021	Kaplan-Meier Survival Analysis
MESO	0.00026	Kaplan-Meier Survival Analysis
ACC	0.00016	Kaplan-Meier Survival Analysis
PCPG	0.048	Kaplan-Meier Survival Analysis
CESC	0.047	Kaplan-Meier Survival Analysis
UCEC	0.029	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.044	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000130695 (Gene tree)
Gene ID: 64793
Gene Symbol: CEP85
Alias: DKFZP434L0117|CCDC21
Full Name: centrosomal protein 85
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 44,886 bases
Position: chr1:26,234,153-26,279,038
Accession: 25309
RBP type: non-canonical RBP
Summary: This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491670	CEP85-207	941	-	-	- (aa)	-	-
ENST00000252992	CEP85-201	3935	XM_024449198	ENSP00000252992	762 (aa)	XP_024304966	Q6P2H3
ENST00000451429	CEP85-202	3922	XM_017002105	ENSP00000417002	761 (aa)	XP_016857594	Q6P2H3
ENST00000640292	CEP85-208	2663	-	ENSP00000492362	711 (aa)	-	Q6P2H3
ENST00000469609	CEP85-205	2384	-	-	- (aa)	-	-
ENST00000453146	CEP85-203	2821	-	ENSP00000391790	435 (aa)	-	H7BZW2
ENST00000480446	CEP85-206	435	-	-	- (aa)	-	-
ENST00000468163	CEP85-204	453	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000130695's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130695	Transforming Growth Factor beta	9E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130695	rs10902723	1	26242051	G	Obesity-related traits	23251661	[NR] pg/mL increase	0.01	EFO_0004818
ENSG00000130695	rs11577318	1	26275079	G	Granulocyte percentage of myeloid white cells	27863252	[0.022-0.04] unit increase	0.03076225	EFO_0007997

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130695's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000242	pericentriolar material	26220856.	IDA	Component
GO:0000922	spindle pole	21399614.	IDA	Component
GO:0005515	protein binding	18985028.21044950.26220856.	IPI	Function
GO:0005730	nucleolus	21399614.	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	21399614.26220856.	IDA	Component
GO:0005815	microtubule organizing center	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006469	negative regulation of protein kinase activity	26220856.	IMP	Process
GO:0007059	chromosome segregation	-	IEA	Process
GO:0046602	regulation of mitotic centrosome separation	26220856.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.