EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr9	130695554	Missense_Mutation	rs748977410	R62T	0.3	ECR1_N
BLCA	chr9	130703848	3'UTR	novel		0.1
BLCA	chr9	130693820	Missense_Mutation	NA	A10V	0.26
BRCA	chr9	130702087	Intron	novel		0.2
BRCA	chr9	130695491	Splice_Site	NA	X42_splice	0.27
CESC	chr9	130699363	Missense_Mutation	novel	R132T	0.4
CESC	chr9	130693779	5'UTR	novel		0.17
COAD	chr9	130693849	Missense_Mutation	rs140638723	R20S	0.37
COAD	chr9	130695492	Splice_Region	NA	R41R	0.3
ESCA	chr9	130697589	Missense_Mutation	novel	G78S	0.58
GBM	chr9	130702199	Missense_Mutation	novel	H187Q	0.33
HNSC	chr9	130703869	3'UTR	novel		0.37
HNSC	chr9	130698179	Nonsense_Mutation	novel	W96*	0.3
HNSC	chr9	130693896	Silent	novel	T35T	0.51
HNSC	chr9	130703882	3'UTR	novel		0.15
HNSC	chr9	130703884	3'UTR	novel		0.08
KIRP	chr9	130703767	Frame_Shift_Del	novel	*E292Gfs57**	0.49
LUAD	chr9	130698175	Missense_Mutation	novel	R95M	0.29
LUAD	chr9	130702183	Missense_Mutation	novel	Q182L	0.27
LUAD	chr9	130693914	Splice_Site	novel	X41_splice	0.32
LUSC	chr9	130702286	Frame_Shift_Ins	novel	*F219Lfs12**	0.35
LUSC	chr9	130702136	Splice_Region	novel	L166L	0.49
LUSC	chr9	130695489	Splice_Region	novel		0.1
OV	chr9	130703076	Missense_Mutation	NA	E232D	0.17
OV	chr9	130703946	3'UTR	novel		0.33
OV	chr9	130695584	Nonsense_Mutation	novel	L72*	0.04
OV	chr9	130701930	Intron	novel		0.33
READ	chr9	130693839	Missense_Mutation	novel	E16D	0.36
READ	chr9	130703092	Missense_Mutation	rs561877923	R238W	0.51
SARC	chr9	130701062	Intron	novel		0.33
SKCM	chr9	130693779	5'UTR	novel		0.19
SKCM	chr9	130700914	Silent	NA	T158T	0.3
SKCM	chr9	130703071	Nonsense_Mutation	rs149299789	R231*	0.15
SKCM	chr9	130703122	Silent	novel	R248R	0.3
STAD	chr9	130702162	Missense_Mutation	NA	S175F	0.19
THCA	chr9	130703929	3'UTR	novel		0.15
THCA	chr9	130703931	3'UTR	novel		0.15
UCEC	chr9	130702250	Nonsense_Mutation	novel	W204*	0.2
UCEC	chr9	130693878	Frame_Shift_Del	NA	*D31Ifs33**	0.49	ECR1_N
UCEC	chr9	130693843	Silent	novel	L18L	0.33
UCEC	chr9	130699339	Missense_Mutation	novel	S124Y	0.34
UCEC	chr9	130698168	Nonsense_Mutation	NA	Q93*	0.4
UCEC	chr9	130700872	Silent	rs112276515	E144E	0.31
UCEC	chr9	130701972	Intron	novel		0.5
UCEC	chr9	130703862	3'UTR	novel		0.41
UCEC	chr9	130693885	Missense_Mutation	novel	T32A	0.16	ECR1_N
UCEC	chr9	130702070	Intron	novel		0.47
UCEC	chr9	130697606	Silent	novel	I83I	0.42
UCEC	chr9	130703793	3'UTR	rs201500823		0.46
UCEC	chr9	130703700	Missense_Mutation	NA	D270N	0.43
UCEC	chr9	130702288	Missense_Mutation	novel	G217E	0.21
UCEC	chr9	130703937	3'UTR	novel		0.2
UCEC	chr9	130700874	Missense_Mutation	novel	V145A	0.28
UCEC	chr9	130702240	Missense_Mutation	novel	G201D	0.44
UCEC	chr9	130703916	3'UTR	novel		0.24
UCEC	chr9	130700930	Missense_Mutation	novel	G164R	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2056	0.070727
LAML	DEL	0.0105	0.24147
LGG	AMP	0.0604	0.21332
LIHC	DEL	0.2459	0.12467
OV	DEL	0.5492	2.9521e-06
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCEC	DEL	0.2189	0.0022334
UCS	DEL	0.6071	0.089783

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.02	Kaplan-Meier Survival Analysis
STAD	0.039	Kaplan-Meier Survival Analysis
SARC	0.047	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.046	Kaplan-Meier Survival Analysis
SKCM	0.049	Kaplan-Meier Survival Analysis
PRAD	0.012	Kaplan-Meier Survival Analysis
KIRP	0.0029	Kaplan-Meier Survival Analysis
COAD	0.039	Kaplan-Meier Survival Analysis
PAAD	0.022	Kaplan-Meier Survival Analysis
LIHC	0.00032	Kaplan-Meier Survival Analysis
LGG	0.00028	Kaplan-Meier Survival Analysis
LUAD	0.013	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130713 (Gene tree)
Gene ID: 23404
Gene Symbol: EXOSC2
Alias: hRrp4p|Rrp4p|RRP4|p7
Full Name: exosome component 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 11,174 bases
Position: chr9:130,693,721-130,704,894
Accession: 17097
RBP type: canonical RBP
Summary: (Exosome Component 2) is a Protein Coding gene. Diseases associated with EXOSC2 include Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies and Late-Onset Retinal Degeneration. Among its related pathways are PERK regulates gene expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC3.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000361425	ECR1_N	PF14382.6	7.4e-15	1	1
ENSP00000418463	ECR1_N	PF14382.6	9.6e-15	1	1
ENSP00000361426	ECR1_N	PF14382.6	1.2e-14	1	1
ENSP00000444917	ECR1_N	PF14382.6	1.2e-14	1	1
ENSP00000361427	ECR1_N	PF14382.6	1.3e-14	1	1
ENSP00000361433	ECR1_N	PF14382.6	1.3e-14	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11809881	5' exonuclease containing S1 and KH RNA-binding domains.'>Arabidopsis thaliana exosome subunit AtRrp4p is a hydrolytic 3'-->5' exonuclease containing S1 and KH RNA-binding domains.	Nucleic Acids Res	2002 Feb 1	Chekanova JA	-
23324612	The archaeal DnaG protein needs Csl4 for binding to the exosome and enhances its interaction with adenine-rich RNAs.	RNA Biol	2013 Mar	Hou L	doi: 10.4161/rna.23450
17380186	RNA channelling by the archaeal exosome.	EMBO Rep	2007 May	Lorentzen E	-
29159940	Nop5 interacts with the archaeal RNA exosome.	FEBS Lett	2017 Dec	Gauernack AS	doi: 10.1002/1873-3468.12915
12947419	An exosome-like complex in Sulfolobus solfataricus.	EMBO Rep	2003 Sep	Evguenieva-Hackenberg E	-
22503705	Heterogeneous complexes of the RNA exosome in Sulfolobus solfataricus.	Biochimie	2012 Jul	Witharana C	doi: 10.1016/j.biochi.2012.03.026
21713675	The archaeal exosome.	Adv Exp Med Biol	2011	Evguenieva-Hackenberg E	doi: 10.1007/978-1-4419-7841-7_3.
21618872	The archaeal exosome.	Adv Exp Med Biol	2010	Evguenieva-Hackenberg E	-
20488184	The evolutionarily conserved subunits Rrp4 and Csl4 confer different substrate specificities to the archaeal exosome.	FEBS Lett	2010 Jul 2	Roppelt V	doi: 10.1016/j.febslet.2010.05.014
25326320	Archaeal DnaG contains a conserved N-terminal RNA-binding domain and enables tailing of rRNA by the exosome.	Nucleic Acids Res	2014 Nov 10	Hou L	doi: 10.1093/nar/gku969
24789718	Structure and function of the archaeal exosome.	Wiley Interdiscip Rev RNA	2014 Sep-Oct	Evguenieva-Hackenberg E	doi: 10.1002/wrna.1234
28288106	The Rrp4-exosome complex recruits and channels substrate RNA by a unique mechanism.	Nat Chem Biol	2017 May	Cvetkovic MA	doi: 10.1038/nchembio.2328
17159918	Structural and biochemical characterization of the yeast exosome component Rrp40.	EMBO Rep	2007 Jan	Oddone A	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430138	EXOSC2-205	2533	-	-	- (aa)	-	-
ENST00000495699	EXOSC2-210	709	-	ENSP00000418463	237 (aa)	-	A3KFL5
ENST00000463488	EXOSC2-206	699	-	-	- (aa)	-	-
ENST00000546165	EXOSC2-211	1956	-	ENSP00000444917	267 (aa)	-	Q13868
ENST00000372352	EXOSC2-203	1957	-	ENSP00000361427	285 (aa)	-	A3KFL2
ENST00000372351	EXOSC2-202	1885	XM_006717023	ENSP00000361426	263 (aa)	XP_006717086	Q13868
ENST00000372350	EXOSC2-201	606	-	ENSP00000361425	200 (aa)	-	A3KFL1
ENST00000467138	EXOSC2-207	2766	-	-	- (aa)	-	-
ENST00000490641	EXOSC2-208	699	-	-	- (aa)	-	-
ENST00000491115	EXOSC2-209	739	-	-	- (aa)	-	-
ENST00000372358	EXOSC2-204	2040	XM_005272176	ENSP00000361433	293 (aa)	XP_005272233	Q13868

Gene Model

Click here to download ENSG00000130713's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130713	Hemoglobin A, Glycosylated	9.4700000E-005	19875614
ENSG00000130713	Hemoglobin A, Glycosylated	9.4530000E-005	19875614

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130713's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130713	EXOSC2	95	75.269	ENSAPOG00000008861	exosc2	97	78.491	Acanthochromis_polyacanthus
ENSG00000130713	EXOSC2	100	96.928	ENSAMEG00000016239	EXOSC2	100	96.928	Ailuropoda_melanoleuca
ENSG00000130713	EXOSC2	100	77.474	ENSACIG00000019054	exosc2	100	77.474	Amphilophus_citrinellus
ENSG00000130713	EXOSC2	100	77.474	ENSAOCG00000004983	exosc2	100	77.474	Amphiprion_ocellaris
ENSG00000130713	EXOSC2	100	77.474	ENSAOCG00000008577	exosc2	100	77.474	Amphiprion_ocellaris
ENSG00000130713	EXOSC2	100	77.474	ENSAPEG00000014088	exosc2	100	77.474	Amphiprion_percula
ENSG00000130713	EXOSC2	100	78.498	ENSATEG00000018680	exosc2	100	78.498	Anabas_testudineus
ENSG00000130713	EXOSC2	96	87.589	ENSAPLG00000012516	EXOSC2	97	87.589	Anas_platyrhynchos
ENSG00000130713	EXOSC2	99	85.274	ENSACAG00000002706	EXOSC2	99	85.274	Anolis_carolinensis
ENSG00000130713	EXOSC2	100	76.792	ENSACLG00000013613	exosc2	100	76.792	Astatotilapia_calliptera
ENSG00000130713	EXOSC2	100	80.339	ENSAMXG00000042605	exosc2	100	80.339	Astyanax_mexicanus
ENSG00000130713	EXOSC2	100	96.246	ENSBTAG00000048071	EXOSC2	100	96.246	Bos_taurus
ENSG00000130713	EXOSC2	91	43.284	WBGene00022232	exos-2	88	43.284	Caenorhabditis_elegans
ENSG00000130713	EXOSC2	100	99.317	ENSCJAG00000020537	EXOSC2	100	99.317	Callithrix_jacchus
ENSG00000130713	EXOSC2	99	96.233	ENSCAFG00000019941	EXOSC2	99	96.233	Canis_familiaris
ENSG00000130713	EXOSC2	100	96.246	ENSCAFG00020024047	EXOSC2	100	96.246	Canis_lupus_dingo
ENSG00000130713	EXOSC2	100	96.246	ENSCHIG00000021398	EXOSC2	100	96.246	Capra_hircus
ENSG00000130713	EXOSC2	100	95.563	ENSTSYG00000001805	EXOSC2	100	95.563	Carlito_syrichta
ENSG00000130713	EXOSC2	100	91.809	ENSCPOG00000005902	EXOSC2	100	91.809	Cavia_porcellus
ENSG00000130713	EXOSC2	100	99.317	ENSCCAG00000019749	EXOSC2	100	99.317	Cebus_capucinus
ENSG00000130713	EXOSC2	100	99.317	ENSCATG00000025389	-	100	99.317	Cercocebus_atys
ENSG00000130713	EXOSC2	100	96.587	ENSCLAG00000006195	EXOSC2	100	96.761	Chinchilla_lanigera
ENSG00000130713	EXOSC2	100	99.317	ENSCSAG00000014760	EXOSC2	100	99.317	Chlorocebus_sabaeus
ENSG00000130713	EXOSC2	100	97.270	ENSCHOG00000000858	EXOSC2	100	97.270	Choloepus_hoffmanni
ENSG00000130713	EXOSC2	99	86.986	ENSCPBG00000022626	EXOSC2	99	86.986	Chrysemys_picta_bellii
ENSG00000130713	EXOSC2	99	59.174	ENSCING00000014934	-	94	61.672	Ciona_intestinalis
ENSG00000130713	EXOSC2	99	61.086	ENSCSAVG00000003684	-	100	61.957	Ciona_savignyi
ENSG00000130713	EXOSC2	99	92.123	ENSCANG00000029298	-	99	92.123	Colobus_angolensis_palliatus
ENSG00000130713	EXOSC2	100	99.317	ENSCANG00000039828	-	100	99.317	Colobus_angolensis_palliatus
ENSG00000130713	EXOSC2	100	95.222	ENSCGRG00001013981	Exosc2	100	95.222	Cricetulus_griseus_chok1gshd
ENSG00000130713	EXOSC2	100	95.222	ENSCGRG00000017629	Exosc2	100	95.222	Cricetulus_griseus_crigri
ENSG00000130713	EXOSC2	100	76.792	ENSCSEG00000016539	exosc2	100	76.792	Cynoglossus_semilaevis
ENSG00000130713	EXOSC2	100	76.451	ENSCVAG00000022260	exosc2	100	76.451	Cyprinodon_variegatus
ENSG00000130713	EXOSC2	100	77.966	ENSDARG00000028688	exosc2	100	77.966	Danio_rerio
ENSG00000130713	EXOSC2	100	89.908	ENSDNOG00000025767	-	100	97.378	Dasypus_novemcinctus
ENSG00000130713	EXOSC2	100	93.857	ENSDORG00000009238	Exosc2	100	93.857	Dipodomys_ordii
ENSG00000130713	EXOSC2	89	61.450	FBgn0034879	Rrp4	89	61.132	Drosophila_melanogaster
ENSG00000130713	EXOSC2	94	78.623	ENSETEG00000016130	-	99	78.623	Echinops_telfairi
ENSG00000130713	EXOSC2	100	97.270	ENSEASG00005008475	EXOSC2	86	97.270	Equus_asinus_asinus
ENSG00000130713	EXOSC2	100	97.270	ENSECAG00000007897	EXOSC2	86	97.270	Equus_caballus
ENSG00000130713	EXOSC2	100	78.644	ENSELUG00000013641	exosc2	100	78.644	Esox_lucius
ENSG00000130713	EXOSC2	100	96.928	ENSFCAG00000025936	EXOSC2	100	96.928	Felis_catus
ENSG00000130713	EXOSC2	98	83.275	ENSFALG00000001446	EXOSC2	98	83.275	Ficedula_albicollis
ENSG00000130713	EXOSC2	100	95.563	ENSFDAG00000017196	EXOSC2	100	95.563	Fukomys_damarensis
ENSG00000130713	EXOSC2	100	77.133	ENSFHEG00000018571	exosc2	100	77.133	Fundulus_heteroclitus
ENSG00000130713	EXOSC2	100	73.379	ENSGMOG00000011785	exosc2	99	73.379	Gadus_morhua
ENSG00000130713	EXOSC2	99	85.616	ENSGALG00000040373	EXOSC2	99	85.616	Gallus_gallus
ENSG00000130713	EXOSC2	99	76.027	ENSGAFG00000010283	exosc2	99	76.027	Gambusia_affinis
ENSG00000130713	EXOSC2	100	75.427	ENSGACG00000016805	exosc2	100	76.647	Gasterosteus_aculeatus
ENSG00000130713	EXOSC2	87	90.196	ENSGAGG00000021026	EXOSC2	96	90.196	Gopherus_agassizii
ENSG00000130713	EXOSC2	100	99.317	ENSGGOG00000010578	EXOSC2	100	99.317	Gorilla_gorilla
ENSG00000130713	EXOSC2	100	77.474	ENSHBUG00000022437	exosc2	100	77.474	Haplochromis_burtoni
ENSG00000130713	EXOSC2	100	96.928	ENSHGLG00000012834	EXOSC2	100	97.166	Heterocephalus_glaber_female
ENSG00000130713	EXOSC2	100	96.928	ENSHGLG00100007092	EXOSC2	100	97.166	Heterocephalus_glaber_male
ENSG00000130713	EXOSC2	100	75.427	ENSHCOG00000019130	exosc2	100	75.427	Hippocampus_comes
ENSG00000130713	EXOSC2	100	77.891	ENSIPUG00000015397	exosc2	100	77.891	Ictalurus_punctatus
ENSG00000130713	EXOSC2	100	96.246	ENSSTOG00000005999	EXOSC2	100	96.246	Ictidomys_tridecemlineatus
ENSG00000130713	EXOSC2	100	95.222	ENSJJAG00000003188	Exosc2	100	95.222	Jaculus_jaculus
ENSG00000130713	EXOSC2	99	77.397	ENSKMAG00000017397	exosc2	99	77.397	Kryptolebias_marmoratus
ENSG00000130713	EXOSC2	100	76.792	ENSLBEG00000019269	exosc2	100	76.792	Labrus_bergylta
ENSG00000130713	EXOSC2	100	83.673	ENSLACG00000015530	EXOSC2	100	83.673	Latimeria_chalumnae
ENSG00000130713	EXOSC2	100	97.279	ENSLAFG00000006984	EXOSC2	100	97.279	Loxodonta_africana
ENSG00000130713	EXOSC2	100	99.317	ENSMFAG00000000597	-	100	99.317	Macaca_fascicularis
ENSG00000130713	EXOSC2	100	85.666	ENSMFAG00000034160	-	84	85.666	Macaca_fascicularis
ENSG00000130713	EXOSC2	100	98.947	ENSMMUG00000012498	EXOSC2	100	98.947	Macaca_mulatta
ENSG00000130713	EXOSC2	100	86.689	ENSMNEG00000028704	-	91	86.689	Macaca_nemestrina
ENSG00000130713	EXOSC2	100	99.317	ENSMNEG00000031861	-	100	99.317	Macaca_nemestrina
ENSG00000130713	EXOSC2	100	99.317	ENSMLEG00000042587	-	100	99.317	Mandrillus_leucophaeus
ENSG00000130713	EXOSC2	100	85.666	ENSMLEG00000029891	-	91	85.666	Mandrillus_leucophaeus
ENSG00000130713	EXOSC2	100	77.816	ENSMAMG00000012466	exosc2	100	77.816	Mastacembelus_armatus
ENSG00000130713	EXOSC2	100	76.451	ENSMZEG00005018737	exosc2	100	76.451	Maylandia_zebra
ENSG00000130713	EXOSC2	99	85.616	ENSMGAG00000005450	EXOSC2	99	85.616	Meleagris_gallopavo
ENSG00000130713	EXOSC2	100	94.881	ENSMAUG00000008299	Exosc2	100	94.881	Mesocricetus_auratus
ENSG00000130713	EXOSC2	100	97.611	ENSMICG00000015495	EXOSC2	100	97.611	Microcebus_murinus
ENSG00000130713	EXOSC2	100	94.881	ENSMOCG00000008262	Exosc2	100	94.881	Microtus_ochrogaster
ENSG00000130713	EXOSC2	100	78.157	ENSMMOG00000009616	exosc2	100	78.157	Mola_mola
ENSG00000130713	EXOSC2	100	92.833	ENSMODG00000012114	EXOSC2	100	92.833	Monodelphis_domestica
ENSG00000130713	EXOSC2	100	77.474	ENSMALG00000022132	exosc2	100	77.474	Monopterus_albus
ENSG00000130713	EXOSC2	100	93.857	MGP_CAROLIEiJ_G0023415	Exosc2	100	94.595	Mus_caroli
ENSG00000130713	EXOSC2	100	93.857	ENSMUSG00000039356	Exosc2	100	94.595	Mus_musculus
ENSG00000130713	EXOSC2	100	94.198	MGP_PahariEiJ_G0024872	Exosc2	100	94.595	Mus_pahari
ENSG00000130713	EXOSC2	100	93.857	MGP_SPRETEiJ_G0024332	Exosc2	100	94.595	Mus_spretus
ENSG00000130713	EXOSC2	100	96.246	ENSMPUG00000012686	EXOSC2	100	96.246	Mustela_putorius_furo
ENSG00000130713	EXOSC2	100	96.949	ENSMLUG00000008776	EXOSC2	100	96.949	Myotis_lucifugus
ENSG00000130713	EXOSC2	100	95.222	ENSNGAG00000019383	Exosc2	100	95.222	Nannospalax_galili
ENSG00000130713	EXOSC2	100	77.133	ENSNBRG00000005453	exosc2	100	77.133	Neolamprologus_brichardi
ENSG00000130713	EXOSC2	100	100.000	ENSNLEG00000012533	EXOSC2	100	100.000	Nomascus_leucogenys
ENSG00000130713	EXOSC2	100	75.229	ENSMEUG00000000795	EXOSC2	100	72.014	Notamacropus_eugenii
ENSG00000130713	EXOSC2	83	96.970	ENSOPRG00000008688	EXOSC2	65	96.970	Ochotona_princeps
ENSG00000130713	EXOSC2	100	93.174	ENSODEG00000016880	-	100	93.174	Octodon_degus
ENSG00000130713	EXOSC2	87	93.701	ENSODEG00000019513	-	100	93.701	Octodon_degus
ENSG00000130713	EXOSC2	100	77.133	ENSONIG00000014086	exosc2	100	77.133	Oreochromis_niloticus
ENSG00000130713	EXOSC2	100	84.642	ENSOANG00000001044	EXOSC2	100	84.642	Ornithorhynchus_anatinus
ENSG00000130713	EXOSC2	100	95.222	ENSOCUG00000007138	EXOSC2	100	95.222	Oryctolagus_cuniculus
ENSG00000130713	EXOSC2	100	77.474	ENSORLG00000007443	exosc2	100	77.474	Oryzias_latipes
ENSG00000130713	EXOSC2	100	77.133	ENSORLG00020018902	exosc2	100	77.133	Oryzias_latipes_hni
ENSG00000130713	EXOSC2	100	77.474	ENSORLG00015006767	exosc2	100	77.474	Oryzias_latipes_hsok
ENSG00000130713	EXOSC2	100	76.451	ENSOMEG00000003533	exosc2	100	76.451	Oryzias_melastigma
ENSG00000130713	EXOSC2	100	97.952	ENSOGAG00000007558	EXOSC2	100	97.952	Otolemur_garnettii
ENSG00000130713	EXOSC2	100	95.932	ENSOARG00000007438	EXOSC2	100	95.932	Ovis_aries
ENSG00000130713	EXOSC2	100	100.000	ENSPPAG00000034796	EXOSC2	100	100.000	Pan_paniscus
ENSG00000130713	EXOSC2	100	96.587	ENSPPRG00000001089	EXOSC2	100	96.587	Panthera_pardus
ENSG00000130713	EXOSC2	100	96.587	ENSPTIG00000021163	EXOSC2	100	96.587	Panthera_tigris_altaica
ENSG00000130713	EXOSC2	100	100.000	ENSPTRG00000045766	-	100	100.000	Pan_troglodytes
ENSG00000130713	EXOSC2	100	100.000	ENSPTRG00000021476	EXOSC2	100	100.000	Pan_troglodytes
ENSG00000130713	EXOSC2	100	99.317	ENSPANG00000025966	EXOSC2	100	99.317	Papio_anubis
ENSG00000130713	EXOSC2	99	80.277	ENSPKIG00000004271	exosc2	98	80.277	Paramormyrops_kingsleyae
ENSG00000130713	EXOSC2	99	87.671	ENSPSIG00000006743	EXOSC2	99	87.671	Pelodiscus_sinensis
ENSG00000130713	EXOSC2	86	79.051	ENSPMGG00000010980	exosc2	99	79.051	Periophthalmus_magnuspinnatus
ENSG00000130713	EXOSC2	100	94.881	ENSPEMG00000006345	Exosc2	100	94.881	Peromyscus_maniculatus_bairdii
ENSG00000130713	EXOSC2	100	76.271	ENSPMAG00000001280	exosc2	100	76.271	Petromyzon_marinus
ENSG00000130713	EXOSC2	100	93.174	ENSPCIG00000024122	EXOSC2	97	93.174	Phascolarctos_cinereus
ENSG00000130713	EXOSC2	99	76.451	ENSPFOG00000019819	exosc2	99	76.451	Poecilia_formosa
ENSG00000130713	EXOSC2	99	76.712	ENSPLAG00000004605	exosc2	99	76.712	Poecilia_latipinna
ENSG00000130713	EXOSC2	99	76.712	ENSPMEG00000010976	exosc2	99	76.712	Poecilia_mexicana
ENSG00000130713	EXOSC2	99	76.370	ENSPREG00000014306	exosc2	99	76.370	Poecilia_reticulata
ENSG00000130713	EXOSC2	100	99.659	ENSPPYG00000019695	EXOSC2	100	99.659	Pongo_abelii
ENSG00000130713	EXOSC2	100	96.928	ENSPCAG00000013400	EXOSC2	100	96.928	Procavia_capensis
ENSG00000130713	EXOSC2	100	97.952	ENSPCOG00000017639	EXOSC2	100	97.952	Propithecus_coquereli
ENSG00000130713	EXOSC2	100	95.563	ENSPVAG00000001513	EXOSC2	100	95.563	Pteropus_vampyrus
ENSG00000130713	EXOSC2	100	77.474	ENSPNYG00000007383	exosc2	100	77.474	Pundamilia_nyererei
ENSG00000130713	EXOSC2	100	80.272	ENSPNAG00000014281	exosc2	100	80.272	Pygocentrus_nattereri
ENSG00000130713	EXOSC2	100	94.881	ENSRNOG00000009245	Exosc2	100	94.881	Rattus_norvegicus
ENSG00000130713	EXOSC2	99	92.808	ENSRBIG00000029791	-	99	92.808	Rhinopithecus_bieti
ENSG00000130713	EXOSC2	100	98.976	ENSRBIG00000031203	-	100	98.976	Rhinopithecus_bieti
ENSG00000130713	EXOSC2	99	91.096	ENSRROG00000043609	-	99	91.096	Rhinopithecus_roxellana
ENSG00000130713	EXOSC2	100	98.976	ENSRROG00000010827	-	100	98.976	Rhinopithecus_roxellana
ENSG00000130713	EXOSC2	86	50.000	YHR069C	-	82	41.554	Saccharomyces_cerevisiae
ENSG00000130713	EXOSC2	100	98.976	ENSSBOG00000022712	EXOSC2	100	98.976	Saimiri_boliviensis_boliviensis
ENSG00000130713	EXOSC2	100	92.150	ENSSHAG00000016050	EXOSC2	100	92.150	Sarcophilus_harrisii
ENSG00000130713	EXOSC2	100	78.840	ENSSFOG00015011245	exosc2	100	78.840	Scleropages_formosus
ENSG00000130713	EXOSC2	100	76.792	ENSSMAG00000003112	exosc2	100	76.792	Scophthalmus_maximus
ENSG00000130713	EXOSC2	100	76.689	ENSSDUG00000004634	exosc2	100	76.689	Seriola_dumerili
ENSG00000130713	EXOSC2	100	77.474	ENSSLDG00000010616	exosc2	100	77.474	Seriola_lalandi_dorsalis
ENSG00000130713	EXOSC2	99	87.119	ENSSPUG00000013391	EXOSC2	99	87.119	Sphenodon_punctatus
ENSG00000130713	EXOSC2	100	77.474	ENSSPAG00000022947	exosc2	100	77.474	Stegastes_partitus
ENSG00000130713	EXOSC2	100	97.952	ENSSSCG00000005704	EXOSC2	100	97.952	Sus_scrofa
ENSG00000130713	EXOSC2	99	82.534	ENSTGUG00000004697	EXOSC2	99	82.534	Taeniopygia_guttata
ENSG00000130713	EXOSC2	100	73.720	ENSTRUG00000022436	exosc2	100	73.720	Takifugu_rubripes
ENSG00000130713	EXOSC2	100	89.761	ENSTTRG00000015159	EXOSC2	100	89.761	Tursiops_truncatus
ENSG00000130713	EXOSC2	100	88.991	ENSUAMG00000009651	EXOSC2	99	93.863	Ursus_americanus
ENSG00000130713	EXOSC2	100	96.587	ENSUMAG00000018726	EXOSC2	100	96.587	Ursus_maritimus
ENSG00000130713	EXOSC2	100	96.246	ENSVVUG00000027665	EXOSC2	100	96.246	Vulpes_vulpes
ENSG00000130713	EXOSC2	100	79.522	ENSXETG00000001340	exosc2	100	79.522	Xenopus_tropicalis
ENSG00000130713	EXOSC2	99	76.712	ENSXMAG00000005265	exosc2	99	76.712	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	8600032.	TAS	Function
GO:0000176	nuclear exosome (RNase complex)	21873635.	IBA	Component
GO:0000176	nuclear exosome (RNase complex)	26166824.	IDA	Component
GO:0000177	cytoplasmic exosome (RNase complex)	21873635.	IBA	Component
GO:0000178	exosome (RNase complex)	21873635.	IBA	Component
GO:0000178	exosome (RNase complex)	20531389.	IDA	Component
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0004532	exoribonuclease activity	17174896.	IDA	Function
GO:0005515	protein binding	11719186.12419256.15231747.15687258.16396833.17545563.18326031.20531386.20531389.21255825.26496610.	IPI	Function
GO:0005634	nucleus	17545563.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	17545563.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006364	rRNA processing	-	TAS	Process
GO:0008312	7S RNA binding	8600032.	TAS	Function
GO:0030307	positive regulation of cell growth	17545563.	IMP	Process
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	21873635.	IBA	Process
GO:0034475	U4 snRNA 3'-end processing	21873635.	IBA	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	21873635.	IBA	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0071034	CUT catabolic process	21873635.	IBA	Process
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	21873635.	IBA	Process
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	21873635.	IBA	Process
GO:0071049	nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription	21873635.	IBA	Process
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	21873635.	IBA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.