EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24983967Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines.PLoS One2014 Jul 1Chen Ldoi: 10.1371/journal.pone.0101040
27845900TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development.Oncotarget2017 Jan 3Czerwi??ska Pdoi: 10.18632/oncotarget.13273.
27095111KAP1 is overexpressed in hepatocellular carcinoma and its clinical significance.Int J Clin Oncol2016 OctWang Y-
28864417TIF1β is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism.Biochem Biophys Res Commun2017 Oct 21Shen LTdoi: 10.1016/j.bbrc.2017.08.117
30309319Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells.BMC Cancer2018 Oct 11Song Xdoi: 10.1186/s12885-018-4844-1.
24861921KAP-1 is overexpressed and correlates with increased metastatic ability and tumorigenicity in pancreatic cancer.Med Oncol2014 JulYu Cdoi: 10.1007/s12032-014-0025-5
27412325Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein.Sci Rep2016 Jul 14Wei Cdoi: 10.1038/srep29822.
25421577KAP1 promotes proliferation and metastatic progression of breast cancer cells.Cancer Res2015 Jan 15Addison JBdoi: 10.1158/0008-5472.CAN-14-1561
23548070Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer.World J Surg Oncol2013 Apr 2Wang YYdoi: 10.1186/1477-7819-11-81.
19898899KAP1 is associated with peritoneal carcinomatosis in gastric cancer.Ann Surg Oncol2010 MarYokoe Tdoi: 10.1245/s10434-009-0795-8
22959342TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer.Cancer Epidemiol2013 FebLiu Ldoi: 10.1016/j.canep.2012.08.005
25548895High levels of KAP1 expression are associated with aggressive clinical features in ovarian cancer.Int J Mol Sci2014 Dec 26Cui Ydoi: 10.3390/ijms16010363.
27364555Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells.Cancer Res2016 Sep 1Cheng CTdoi: 10.1158/0008-5472.CAN-15-2921
28498400TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer.Oncol Rep2017 JunLiu Ldoi: 10.3892/or.2017.5638
29393469TRIM28 promotes cervical cancer growth through the mTOR signaling pathway.Oncol Rep2018 AprLi Fdoi: 10.3892/or.2018.6235
30479348TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.Nat Commun2018 Nov 27Fong KWdoi: 10.1038/s41467-018-07475-5.
29917268KAP1 inhibits the Raf-MEK-ERK pathway to promote tumorigenesis in A549 lung cancer cells.Mol Carcinog2018 OctWu GJdoi: 10.1002/mc.22853

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1958545827SilentNAL173L0.26
BLCAchr1958547814Nonsense_MutationnovelQ288*0.18
BLCAchr1958549415Missense_MutationNAE583K0.13
BLCAchr1958548326Missense_MutationNAM378I0.07
BLCAchr1958547861Missense_MutationnovelM303I0.51
BLCAchr1958548124Missense_MutationnovelA349T0.26
BRCAchr1958548503Missense_Mutationrs759243122R412C0.29
BRCAchr1958547884Missense_MutationnovelR311H0.1
BRCAchr19585506033'UTRnovel0.46
BRCAchr1958547456Missense_MutationnovelS223G0.16
BRCAchr1958550182SilentNAI743I0.49
BRCAchr1958545833Missense_MutationNAE175K0.19
BRCAchr1958548320SilentNAL376L0.3
BRCAchr1958548579Missense_MutationNAS437C0.2
BRCAchr1958549770SilentNAL672L0.48
CESCchr1958548085Frame_Shift_InsnovelK340Dfs*190.13
CESCchr1958549064Missense_MutationnovelD496N0.36
CESCchr1958545486Missense_MutationNAF134L0.23
CESCchr1958550422Missense_MutationnovelE793K0.16
CESCchr1958548068Missense_MutationnovelR330Q0.38
CESCchr1958549800SilentNAL682L0.41
COADchr1958549984Silentrs756462692H714H0.27
COADchr19585505943'UTRrs2015457750.62
COADchr1958549996SilentnovelR718R0.23
COADchr1958545477Missense_MutationNAE131D0.32
COADchr1958549995Missense_MutationNAR718H0.06
COADchr1958549496Missense_MutationnovelG610C0.36
COADchr1958549953Missense_MutationNAC704Y0.21
COADchr1958548901Missense_MutationnovelG467D0.06
COADchr1958549037Nonsense_MutationNAR487*0.34
GBMchr1958547803Missense_MutationnovelV284G0.25
GBMchr1958548373Missense_MutationnovelD394V0.16
GBMchr1958547632Missense_MutationnovelR253H0.18
GBMchr1958549531SilentnovelL621L0.04
HNSCchr1958549361Missense_MutationnovelP565T0.21
HNSCchr1958550476Missense_MutationnovelE811Q0.12
KIRCchr1958545771Missense_MutationNAT154S0.21
KIRCchr1958549645SilentnovelV659V0.1
KIRCchr1958548745Missense_MutationNAM443I0.12
KIRPchr1958545496Missense_MutationnovelS138G0.41
KIRPchr19585506223'UTRnovel0.19
KIRPchr1958545831Missense_MutationNAC174Y0.38
LAMLchr1958549105Frame_Shift_DelnovelP510Qfs*1660.3
LGGchr1958549651Splice_SitenovelX661_splice0.47
LGGchr1958545874SilentnovelK188K0.25
LGGchr1958550414Missense_Mutationrs373226669R790H0.35
LIHCchr1958547710Missense_MutationnovelS279N0.32
LIHCchr1958547463Missense_MutationnovelD225V0.22
LIHCchr1958548313Missense_MutationNAR374Q0.28
LIHCchr1958549816Missense_MutationNAD688Y0.84
LIHCchr1958545855Missense_MutationNAQ182R0.4
LUADchr1958548293Splice_SitenovelX368_splice0.18
LUADchr1958549232Missense_MutationnovelI552V0.11
LUADchr1958549100Missense_MutationNAV508L0.48
LUADchr1958547811Missense_Mutationrs758388758V287I0.18
LUADchr1958549436Missense_MutationNAP590S0.16
LUADchr1958550433Missense_MutationnovelM796I0.09
LUSCchr1958550017SilentnovelT725T0.14
LUSCchr1958550467Missense_MutationnovelV808L0.25
LUSCchr1958550023Silentrs763622570S727S0.19
LUSCchr1958549416Missense_MutationnovelE583V0.25
LUSCchr1958549421Missense_MutationnovelP585A0.31
MESOchr1958550203In_Frame_DelnovelL751del0.16
OVchr1958549051SilentnovelE491E0.29
PRADchr1958549051Missense_MutationnovelE491D0.21
PRADchr1958547714Splice_SitenovelX280_splice0.36
PRADchr1958549378Silentrs373664048E570E0.31
PRADchr1958549754Missense_Mutationrs767456825S667L0.42
READchr1958549985Missense_Mutationrs780327650E715K0.31
READchr19585506713'UTRnovel0.4
READchr1958549189Silentrs142762100A537A0.2
SKCMchr1958549428Missense_Mutationrs375189696A587V0.23
SKCMchr1958549510SilentNAP614P0.23
SKCMchr1958548545Missense_MutationnovelP426S0.24
SKCMchr1958547700Missense_MutationnovelE276K0.38
SKCMchr1958547399Missense_MutationNAE204K0.69
SKCMchr1958547665Missense_MutationNAG264E0.28
SKCMchr1958549052Missense_MutationNAR492C0.45
SKCMchr1958548320SilentNAL376L0.22
SKCMchr1958550155Silentrs778163708P734P0.41
SKCMchr1958548520SilentNAS417S0.13
SKCMchr1958549216SilentnovelP546P0.28
SKCMchr1958545791Missense_Mutationrs757143187P161S0.56
SKCMchr1958545792Missense_MutationnovelP161L0.56
SKCMchr19585505663'UTRnovel0.6
SKCMchr1958547476SilentnovelC229C0.38
STADchr1958549052Frame_Shift_InsnovelR492Qfs*90.26
STADchr19585505853'UTRnovel0.21
STADchr1958549554Missense_MutationNAR629H0.87
STADchr1958549117SilentnovelT513T0.41
STADchr1958549839Missense_MutationNAK695N0.06
STADchr1958550181Missense_MutationNAI743T0.31
STADchr1958545835SilentNAE175E0.11
STADchr1958547815Missense_MutationNAQ288R0.28
STADchr1958550217Missense_MutationnovelY755C0.35
STADchr1958547459Missense_MutationNAC224R0.29
STADchr1958549161Missense_MutationNAA528D0.26
STADchr1958548737Splice_Regionnovel0.11
STADchr1958549331Missense_MutationNAE555Q0.06
STADchr1958548109Missense_MutationNAH344Y0.12
TGCTchr1958549101Missense_MutationnovelV508D0.21
THCAchr1958548911Splice_SitenovelX470_splice0.17
UCECchr1958549147SilentNAE523E0.22
UCECchr1958548151Missense_MutationnovelN358D0.42
UCECchr1958549651Splice_SitenovelX661_splice0.32
UCECchr1958548398Silentrs142842422A402A0.2
UCECchr1958549985Missense_Mutationrs780327650E715K0.19
UCECchr1958547714Splice_SitenovelX280_splice0.4
UCECchr1958549574Missense_MutationnovelD636N0.47
UCECchr1958550523SilentnovelE826E0.35
UCECchr19585507033'UTRnovel0.5
UCECchr1958549962Missense_MutationNAV707A0.23
UCECchr1958549594SilentNAQ642Q0.18
UCECchr1958545477SilentNAE131E0.12
UCECchr1958547841Missense_MutationNAM297V0.11
UCECchr1958545897Splice_SitenovelX196_splice0.06
UCECchr1958545477Missense_MutationNAE131D0.25
UCECchr1958548314SilentNAR374R0.49
UCECchr1958548354Missense_MutationnovelE388K0.35
UCECchr1958550513Missense_MutationnovelS823I0.4
UCECchr1958549751Missense_MutationnovelC666Y0.3
UCECchr1958550391SilentnovelV782V0.35
UCECchr1958547462Missense_MutationNAD225N0.32
UCECchr1958547658Missense_Mutationrs775103162R262C0.46
UCECchr1958549460Missense_MutationnovelS598G0.38
UCECchr1958549844Nonsense_MutationNAS697*0.24
UCECchr1958545875Missense_MutationnovelD189N0.39
UCECchr1958547461SilentnovelC224C0.49
UCECchr1958545827Missense_MutationnovelL173M0.44
UCECchr1958547851Missense_MutationNAL300Q0.47
UCECchr1958548085Missense_MutationnovelT336S0.04
UCECchr1958548993Missense_MutationnovelR472H0.31
UCECchr1958549189Silentrs142762100A537A0.37
UCECchr1958549854SilentnovelN700N0.41
UCECchr1958550183Missense_MutationnovelR744C0.17
UCECchr1958549858Missense_MutationNAR702W0.23
UCECchr1958549178Missense_MutationnovelP534S0.33
UCECchr1958550253Missense_Mutationrs200494482R767H0.26
UCECchr1958550436Silentrs375142648N797N0.24
UCECchr1958547698Missense_MutationnovelK275T0.06
UCECchr1958545466Missense_MutationNAD128Y0.33
UCECchr1958549236Missense_MutationnovelV553A0.32
UCECchr1958549574Missense_MutationnovelD636N0.37
UCECchr1958549468Silentrs770754268S600S0.39
UCECchr1958549417Missense_MutationnovelE583D0.1
UCECchr1958548323SilentnovelK377K0.37
UCECchr1958549946Splice_Regionrs1115726520.37
UCECchr1958549440Missense_MutationnovelR591H0.19

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.07120.027508
HNSCDEL0.11690.20195
KIRPDEL0.04510.054726
OVDEL0.44568.1256e-19
PAADDEL0.06520.035089
READDEL0.0970.23023
SARCDEL0.30746.413e-12
TGCTDEL0.280.0046229
UCECDEL0.10760.0003803
UCSDEL0.19640.12448

Survival Analysis
CancerP-value Q-value
THYM0.0045

Kaplan-Meier Survival Analysis

STAD0.033

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

KIRP0.0058

Kaplan-Meier Survival Analysis

PAAD0.011

Kaplan-Meier Survival Analysis

LIHC0.00013

Kaplan-Meier Survival Analysis

DLBC0.018

Kaplan-Meier Survival Analysis

LGG0.0079

Kaplan-Meier Survival Analysis

LUAD0.00016

Kaplan-Meier Survival Analysis

UVM0.005

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000130726 (Gene tree)
Gene ID
10155
Gene Symbol
TRIM28
Alias
TIF1B|KAP1|TF1B|RNF96|PPP1R157
Full Name
tripartite motif containing 28
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
6,632 bases
Position
chr19:58,544,091-58,550,722
Accession
16384
RBP type
non-canonical RBP
Summary
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
29937225A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity.Cell2018 Jul 12Percharde Mdoi: 10.1016/j.cell.2018.05.043
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000595028TRIM28-205486--- (aa)--
ENST00000597618TRIM28-210609--- (aa)--
ENST00000597995TRIM28-212702--- (aa)--
ENST00000253024TRIM28-2012960XM_024451309ENSP00000253024835 (aa)XP_024307077Q13263
ENST00000598355TRIM28-213714--- (aa)--
ENST00000593582TRIM28-203533-ENSP00000472586162 (aa)-M0R2I3
ENST00000597136TRIM28-2071552-ENSP00000471303460 (aa)-M0R0K9
ENST00000594806TRIM28-204861-ENSP00000473126178 (aa)-M0R3C0
ENST00000597423TRIM28-209733--- (aa)--
ENST00000595974TRIM28-206665--- (aa)--
ENST00000597172TRIM28-208577--- (aa)--
ENST00000597968TRIM28-211504-ENSP0000047050361 (aa)-M0QZE6
ENST00000601150TRIM28-215915--- (aa)--
ENST00000341753TRIM28-2022709-ENSP00000342232753 (aa)-Q13263
ENST00000600840TRIM28-214338--- (aa)--
Gene Model
Click here to download ENSG00000130726's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130726's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-IEAProcess
GO:0000785chromatin21873635.IBAComponent
GO:0001837epithelial to mesenchymal transition-ISSProcess
GO:0003677DNA binding21873635.IBAFunction
GO:0003677DNA binding9016654.IDAFunction
GO:0003682chromatin binding27029610.IDAFunction
GO:0003713transcription coactivator activity-ISSFunction
GO:0003714transcription corepressor activity21873635.IBAFunction
GO:0003714transcription corepressor activity8769649.IDAFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0004672protein kinase activity-IEAFunction
GO:0004842ubiquitin-protein transferase activity21873635.IBAFunction
GO:0004842ubiquitin-protein transferase activity18082607.IDAFunction
GO:0005515protein binding10330177.11013263.16169070.17704056.18060868.18675275.18854139.19498464.20424263.20562864.20858735.20864041.20936779.21170338.21277283.21549307.21642969.21888893.23543754.23665872.24018422.24657165.26496610.27029610.27123980.27705803.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus8769649.9016654.IDAComponent
GO:0005634nucleus-ISSComponent
GO:0005654nucleoplasm21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005719nuclear euchromatin-IEAComponent
GO:0005720nuclear heterochromatin-IEAComponent
GO:0006281DNA repair17178852.IDAProcess
GO:0006325chromatin organization-IEAProcess
GO:0006367transcription initiation from RNA polymerase II promoter-TASProcess
GO:0007265Ras protein signal transduction24623306.IMPProcess
GO:0007566embryo implantation-IEAProcess
GO:0008270zinc ion binding10653693.11226167.IDAFunction
GO:0016032viral process-IEAProcess
GO:0016567protein ubiquitination-IEAProcess
GO:0016925protein sumoylation21873635.IBAProcess
GO:0016925protein sumoylation18082607.IDAProcess
GO:0016925protein sumoylation-IEAProcess
GO:0019789SUMO transferase activity17298944.EXPFunction
GO:0031625ubiquitin protein ligase binding18082607.IDAFunction
GO:0035851Krueppel-associated box domain binding23665872.IDAFunction
GO:0042307positive regulation of protein import into nucleus23665872.IDAProcess
GO:0043045DNA methylation involved in embryo development-IEAProcess
GO:0043388positive regulation of DNA binding-IEAProcess
GO:0043565sequence-specific DNA binding-ISSFunction
GO:0045087innate immune response18248090.IDAProcess
GO:0045739positive regulation of DNA repair17178852.IDAProcess
GO:0045869negative regulation of single stranded viral RNA replication via double stranded DNA intermediate-IEAProcess
GO:0045892negative regulation of transcription, DNA-templated21873635.IBAProcess
GO:0045892negative regulation of transcription, DNA-templated9016654.IDAProcess
GO:0045893positive regulation of transcription, DNA-templated-ISSProcess
GO:0046777protein autophosphorylation-IEAProcess
GO:0051259protein complex oligomerization17512541.IDAProcess
GO:0060028convergent extension involved in axis elongation-IEAProcess
GO:0060669embryonic placenta morphogenesis-IEAProcess
GO:0070087chromo shadow domain binding15882967.IPIFunction
GO:0090309positive regulation of methylation-dependent chromatin silencing24623306.IMPProcess
GO:0090309positive regulation of methylation-dependent chromatin silencing-ISSProcess
GO:0090575RNA polymerase II transcription factor complex21873635.IBAComponent
GO:0090575RNA polymerase II transcription factor complex-ISSComponent
GO:1901536negative regulation of DNA demethylation-IEAProcess
GO:1902187negative regulation of viral release from host cell18248090.IDAProcess
GO:1990841promoter-specific chromatin binding21873635.IBAFunction
GO:1990841promoter-specific chromatin binding24623306.IDAFunction
GO:2000653regulation of genetic imprinting-IEAProcess
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