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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29975921MiR-137 Suppresses Triple-Negative Breast Cancer Stemness and Tumorigenesis by Perturbing BCL11A-DNMT1 Interaction.Cell Physiol Biochem2018Chen Fdoi: 10.1159/000491526
21999220Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells.J Exp Clin Cancer Res2011 Oct 17Zhang Ydoi: 10.1186/1756-9966-30-98.
22520950Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.Hum Pathol2012 OctBen Gacem Rdoi: 10.1016/j.humpath.2011.12.022
26090723DNMT1-dependent suppression of microRNA424 regulates tumor progression in human bladder cancer.Oncotarget2015 Sep 15Wu CT-
25319390miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.Mol Cancer Ther2014 DecTang Hdoi: 10.1158/1535-7163.MCT-14-0243
27071379Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology.J Transl Med2016 Apr 12Shin Edoi: 10.1186/s12967-016-0840-x.
17093909Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues.Int J Colorectal Dis2007 JunZhu YM-
30002361Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas.Med Sci Monit2018 Jul 13Ma HSdoi: 10.12659/MSM.910608.
23064049DNA methyltransferase 1 is essential for initiation of the colon cancers.Exp Mol Pathol2013 AprMorita Rdoi: 10.1016/j.yexmp.2012.10.004
20093774The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.J Clin Invest2010 FebLin RKdoi: 10.1172/JCI40706
19399937Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.World J Gastroenterol2009 Apr 28Fan H-
17067458[Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes].Zhonghua Kou Qiang Yi Xue Za Zhi2006 JulTian Z-
16801630Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation.J Clin Oncol2006 Aug 10Reu FJ-
15340041Doxorubicin inhibits DNMT1, resulting in conditional apoptosis.Mol Pharmacol2004 DecYokochi T-
24492612Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.J Biol Chem2014 Mar 21Est??ve POdoi: 10.1074/jbc.M113.525279
25700986DNA methyl transferase 1 reduces expression of SRD5A2 in the aging adult prostate.Am J Pathol2015 MarGe Rdoi: 10.1016/j.ajpath.2014.11.020
19292979DNA methyltransferase I is a mediator of doxorubicin-induced genotoxicity in human cancer cells.Biochem Biophys Res Commun2009 May 1Tan HHdoi: 10.1016/j.bbrc.2009.03.065
23671287Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.J Biol Chem2013 Jul 5Kilgore JAdoi: 10.1074/jbc.M112.443895
25948775Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.Oncotarget2015 Jun 20Visp?? S-
18404674Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.Int J Cancer2008 Jul 15Liao Xdoi: 10.1002/ijc.23494.
18049164DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721.Eur J Gastroenterol Hepatol2007 NovFan H-
25231260A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor.Sci Rep2014 Sep 18Chen BFdoi: 10.1038/srep06413.
26305882Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer.Genes Chromosomes Cancer2015 DecJoensuu EIdoi: 10.1002/gcc.22289
21735817[Cytosine methylation in DNA and its role in cancer therapy].Postepy Biochem2011Plitta B-
27286455Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.Oncotarget2016 Jul 12Bai Jdoi: 10.18632/oncotarget.9866.
27845898Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression.Oncotarget2016 Dec 13Chin HGdoi: 10.18632/oncotarget.13271.
29759079S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1.J Ovarian Res2018 May 14Xu Ydoi: 10.1186/s13048-018-0412-1.
29247823The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.Cancer Lett2018 Mar 28Yoon JHdoi: 10.1016/j.canlet.2017.12.016
22768205Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.PLoS One2012Bai Xdoi: 10.1371/journal.pone.0040024
25908435DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.Nat Commun2015 Apr 24Pathania Rdoi: 10.1038/ncomms7910.
24913034Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.Mol Biol Rep2014 SepQiao Fdoi: 10.1007/s11033-014-3439-4
15755728Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.J Biol Chem2005 May 6Agoston AT-
23846337GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle.Clin Cancer Res2013 Sep 1Yoon JHdoi: 10.1158/1078-0432.CCR-12-3675
27906180miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.Cell Death Dis2016 Dec 1Wang Xdoi: 10.1038/cddis.2016.373.
28561650Higher-Level Pathway Objectives of Epigenetic Therapy: A Solution to the p53 Problem in Cancer.Am Soc Clin Oncol Educ Book2017Velcheti Vdoi: 10.14694/EDBK_174175.
28544374Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152.J Biochem Mol Toxicol2017 SepLi Zdoi: 10.1002/jbt.21933
28473984A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk.Biomed Res Int2017Li Hdoi: 10.1155/2017/3971259
29596883Antagonistic activities of miR-148a and DNMT1: Ectopic expression of miR-148a impairs DNMT1 mRNA and dwindle cell proliferation and survival.Gene2018 Jun 20Sengupta Ddoi: 10.1016/j.gene.2018.03.075
28659310DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Kr??ppel-Like Factor 4 Expression.Clin Cancer Res2017 Sep 15Xie VKdoi: 10.1158/1078-0432.CCR-17-0387
29568927miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns.Mol Med Rep2018 MayBibaki Edoi: 10.3892/mmr.2018.8778
25207720Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions.Nutr Cancer2014Krifa Mdoi: 10.1080/01635581.2014.951729
24947242IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation.Int J Cancer2015 Feb 1Liu CCdoi: 10.1002/ijc.29033
24475290Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.PLoS One2014 Jan 27Cacan Edoi: 10.1371/journal.pone.0087455
11932749DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.Nature2002 Apr 4Rhee I-
23666104DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population.Mol Biol Rep2013 AugMostowska Adoi: 10.1007/s11033-013-2589-0
25315069??EF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.Cancer Med2015 JanFukagawa Adoi: 10.1002/cam4.347
25107489Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.J Biomed Sci2014 Aug 9Samaei NMdoi: 10.1186/s12929-014-0073-3.
25595591DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression.Cancer Lett2015 Apr 10Ning Xdoi: 10.1016/j.canlet.2015.01.005
24038143The E2F1/DNMT1 axis is associated with the development of AR negative castration resistant prostate cancer.Prostate2013 DecValdez CDdoi: 10.1002/pros.22715
24502362Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.Mol Cancer2014 Feb 6Li Ddoi: 10.1186/1476-4598-13-26.
26416384Association of DNA methyltransferases expression with global and gene-specific DNA methylation in colorectal cancer cells.Cell Biochem Funct2015 OctSarabi MMdoi: 10.1002/cbf.3126
17322882Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.Nat Genet2007 MarChen T-
24389641Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.Acta Biochim Biophys Sin (Shanghai)2014 MarScott Adoi: 10.1093/abbs/gmt146
16423997De novo CpG island methylation in human cancer cells.Cancer Res2006 Jan 15Jair KW-
16322686Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.Cancer Biol Ther2006 JanTryndyak VP-
23957506Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore.BMC Cancer2013 Aug 17Inoue-Choi Mdoi: 10.1186/1471-2407-13-389.
18505931Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells.Mol Cancer Res2008 MayZhou Qdoi: 10.1158/1541-7786.MCR-07-0330.
25738352Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.Mol Med Rep2015 JulZhang Wdoi: 10.3892/mmr.2015.3402
20980350Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors.Carcinogenesis2011 FebChik Fdoi: 10.1093/carcin/bgq221
21042757HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53.Oncol Rep2010 DecAu Yeung CL-
16424002Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.Cancer Res2006 Jan 15Ting AH-
23079992Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China.Genet Mol Res2012 Dec 17Sun MYdoi: 10.4238/2012.September.26.1.
23549984MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer.Mol Cells2013 AprZuo Jdoi: 10.1007/s10059-013-2314-9
21887463Transcriptional analysis of CXCR4, DNMT3A, DNMT3B and DNMT1 gene expression in primary advanced uterine cervical carcinoma.Int J Oncol2012 MarLuczak MWdoi: 10.3892/ijo.2011.1183
22110720Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer.PLoS One2011He Sdoi: 10.1371/journal.pone.0027684
27087738Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy.Dis Markers2016Jia Zdoi: 10.1155/2016/8578064
25284287Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1.FEBS J2014 DecDevanand Pdoi: 10.1111/febs.13099
23652987The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.Int J Oncol2013 JulKang KAdoi: 10.3892/ijo.2013.1931
20428781DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells.Int J Oncol2010 JunKim H-
26085088The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2'-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells.J Biol Chem2015 Jul 24Yan Fdoi: 10.1074/jbc.M114.633693
25927928miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNA (cytosine-5)-methyltransferase 1(DNMT1) expression.J Transl Med2015 Apr 28Sui Cdoi: 10.1186/s12967-015-0488-y.
20192608Lack of effects of single nucleotide polymorphisms of the DNA methyltransferase 1 gene on gastric cancer in Iranian patients: a case control study.Asian Pac J Cancer Prev2009Khatami F-
24449497Epigenetic reprogramming modulates malignant properties of human liver cancer.Hepatology2014 JunRaggi Cdoi: 10.1002/hep.27026
21523767Expression and function role of DNA methyltransferase 1 in human bladder cancer.Cancer2011 Nov 15Wu CTdoi: 10.1002/cncr.26150
19339266Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.Cancer Res2009 Apr 1Hino Rdoi: 10.1158/0008-5472.CAN-08-3070.
20840813[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma].Zhongguo Fei Ai Za Zhi2010 SepXu Hdoi: 10.3779/j.issn.1009-3419.2010.09.04.
25753001A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.Mol Cancer Res2015 JunSong Jdoi: 10.1158/1541-7786.MCR-13-0644
25950085The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.Cancer Invest2015Zhan Qdoi: 10.3109/07357907.2015.1025794
26454216Interplay between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of the Hedgehog signaling pathway.Cancer Lett2016 Jan 1Cheng Pdoi: 10.1016/j.canlet.2015.09.019
23318422MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine.Oncogene2014 Jan 16Xiang Ydoi: 10.1038/onc.2012.575
21565170Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.Biochem Biophys Res Commun2011 Jun 3Lavoie Gdoi: 10.1016/j.bbrc.2011.04.115
22942708Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the Southern Chinese population.Int J Mol Sci2012Yang XXdoi: 10.3390/ijms13078364
14559786Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation.Cancer Res2003 Oct 1Leu YW-
12496760DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.Nat Genet2003 JanRobert MF-
23254386Increased levels of DNA methyltransferases are associated with the tumorigenic capacity of prostate cancer cells.Oncol Rep2013 MarGravina GLdoi: 10.3892/or.2012.2192
16963560Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.Proc Natl Acad Sci U S A2006 Sep 19Egger G-
17716861Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation.Cell Signal2007 NovSun L-
19957555[Effect of DNA methyltransferase 1 gene silencing on proliferation and apoptosis of HeLa cells].Zhonghua Fu Chan Ke Za Zhi2009 JulZhao XL-
19798569Two-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk.Breast Cancer Res Treat2010 JunYe Cdoi: 10.1007/s10549-009-0569-9
20192566Effects of amino acid substitution polymorphisms of two DNA methyltransferases on susceptibility to sporadic colorectal cancer.Asian Pac J Cancer Prev2009Khatami F-
21565830MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1.Carcinogenesis2011 JulWang Hdoi: 10.1093/carcin/bgr081
24515776MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1.Med Oncol2014 MarYan Jdoi: 10.1007/s12032-014-0879-6
24001151Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells.Mol Cancer2013 Aug 30Agarwal Sdoi: 10.1186/1476-4598-12-99.
17698033Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells.Biochem Biophys Res Commun2007 Oct 12Jagadeesh Sdoi: 10.1016/j.bbrc.2007.08.005
17657744Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer.Int J Cancer2007 Nov 15Kang MY-
27475839DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop.Exp Cell Res2016 Aug 15Sengupta Ddoi: 10.1016/j.yexcr.2016.07.023
28300471Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.Epigenetics2017 Jun 3Vafadar-Isfahani Ndoi: 10.1080/15592294.2017.1300729
28222434A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells.Cell Physiol Biochem2017Han Xdoi: 10.1159/000460618
28102109Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells.J Chemother2017 JunCacan Edoi: 10.1080/1120009X.2016.1277007
27197203Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.Cancer Res2016 Jun 1Pathania Rdoi: 10.1158/0008-5472.CAN-15-2249
28036257Epigenetic therapy in urologic cancers: an update on clinical trials.Oncotarget2017 Feb 14Faleiro Idoi: 10.18632/oncotarget.14226.
27651312LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1.Cancer Res2016 Nov 1Sun M-
27212035DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells.Oncogene2016 Dec 15Rajabi Hdoi: 10.1038/onc.2016.180
28754593LncRNA-SNHG1 contributes to gastric cancer cell proliferation by regulating DNMT1.Biochem Biophys Res Commun2017 Sep 30Hu Ydoi: 10.1016/j.bbrc.2017.07.137
28869603A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.Oncogene2017 Dec 14Yan Fdoi: 10.1038/onc.2017.305
26980709ERα propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells.Oncotarget2016 Apr 12Si Xdoi: 10.18632/oncotarget.8038.
28427182Identification of DBCCR1 as a suppressor in the development of lung cancer that is associated with increased DNA methyltransferase 1.Oncotarget2017 May 16Zhou Gdoi: 10.18632/oncotarget.15826.
28867761SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells.Int J Mol Sci2017 Aug 30Lu Ydoi: 10.3390/ijms18091863.
29854080Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells.Oxid Med Cell Longev2018 Mar 22Zappe Kdoi: 10.1155/2018/3734250
29901158Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.Oncol Rep2018 AugGuo Ydoi: 10.3892/or.2018.6494
29956566Association of five genetic variations in DNMT1 and DNMT3A with gastric cancer in a Chinese population.Future Oncol2018 JulZhou Jdoi: 10.2217/fon-2017-0707
30015946A novel regulatory circuit of miR152 and DNMT1 in human bladder cancer.Oncol Rep2018 SepZhang Hdoi: 10.3892/or.2018.6553
30226601The interaction between miR148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer.Oncol Rep2018 NovHong Ldoi: 10.3892/or.2018.6700
29973691A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy.Oncogene2018 NovDu WWdoi: 10.1038/s41388-018-0369-y
29338433In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9.Hum Gene Ther2018 FebHe ZYdoi: 10.1089/hum.2017.209.
28253728Expression of DNA methylation-related proteins in metastatic breast cancer.Neoplasma2017Cha YJdoi: 10.4149/neo_2017_312.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1910148979Silentrs200928585D859D0.21
BLCAchr1910155889Missense_MutationNAD470N0.42
BLCAchr1910151750In_Frame_DelnovelS682_R689del0.19
BLCAchr1910134257Missense_MutationnovelI1592M0.24
BLCAchr1910140273SilentNAF1177F0.24
BLCAchr1910175574Missense_Mutationrs781646588S189L0.4
BLCAchr1910180861Missense_MutationnovelL48V0.18
BLCAchr1910151464SilentnovelK717K0.1
BLCAchr1910154750SilentnovelL540L0.53
BLCAchr1910175599Missense_MutationNAQ181E0.32
BLCAchr1910177305Missense_MutationNAH170D0.17
BLCAchr1910149546Missense_MutationnovelF815L0.05
BLCAchr1910136244SilentNAL1495L0.22
BLCAchr1910159726Missense_MutationNAI388M0.21
BLCAchr1910159956Intronnovel0.43
BLCAchr1910134246Missense_MutationnovelM1596K0.28
BLCAchr1910156461Silentrs767165265I427I0.21
BLCAchr1910143918Missense_MutationnovelH972Q0.48
BRCAchr1910137989Missense_MutationnovelR1363Q0.5
BRCAchr1910180219Intronnovel0.31
BRCAchr1910138470Missense_MutationNAD1346H0.14
BRCAchr1910140108Missense_MutationnovelM1232I0.11
BRCAchr1910151479Frame_Shift_InsnovelM712Ifs*450.04
BRCAchr1910149638Missense_MutationNAD785N0.35
BRCAchr1910149868Missense_MutationNAP773L0.65
BRCAchr1910149486SilentNAI835I0.14
BRCAchr1910154981Frame_Shift_DelnovelI506Hfs*180.1
BRCAchr1910175573Silentrs201526918S189S0.11
BRCAchr1910137186Missense_MutationnovelS1447L0.37
BRCAchr1910143902Missense_MutationnovelD978H0.05
BRCAchr1910142057Missense_MutationNAG1078C0.31
BRCAchr1910180381SilentNAP138P0.3
BRCAchr1910148981Missense_Mutationrs749258509D859N0.38
BRCAchr1910146481Nonsense_MutationNAE906*0.13
BRCAchr1910146502SilentnovelL899L0.11
BRCAchr1910166684Splice_SitenovelX252_splice0.18
BRCAchr1910139784SilentNAL1264L0.16
CESCchr1910159764Missense_MutationnovelD376H0.24
CESCchr1910162692Missense_MutationNAS312F0.33
CESCchr1910154360Missense_MutationNAQ635P0.26
CESCchr1910151500SilentnovelV705V0.11
CESCchr1910137214Missense_MutationnovelD1438N0.17
CESCchr1910180886Splice_SitenovelX40_splice0.2
CESCchr1910138576Missense_MutationnovelR1310S0.17
CESCchr1910137180Missense_MutationnovelG1449D0.18
CESCchr1910142180Missense_Mutationrs370786558A1037T0.49
CESCchr1910154687SilentnovelV561V0.25
CESCchr1910155014Missense_MutationNAA496V0.34
CESCchr1910154711Silentrs777372271H553H0.22
CESCchr1910180425Missense_MutationnovelD124H0.42
CESCchr1910143984Missense_MutationNAI950M0.29
COADchr1910140094Missense_MutationNAS1237L0.39
COADchr1910180384Silentrs369311643T137T0.2
COADchr1910156448Missense_Mutationrs751093624E432K0.39
COADchr1910154371SilentnovelF631F0.26
COADchr1910154638Missense_MutationnovelT578A0.21
COADchr1910148937Silentrs199832007Y873Y0.23
COADchr1910140141Silentrs139909192C1221C0.07
COADchr1910175574Missense_Mutationrs781646588S189L0.38
COADchr1910137931SilentNAS1382S0.35
COADchr1910162670SilentNAE319E0.26
COADchr1910154710Missense_MutationnovelA554P0.23
COADchr1910154910Missense_MutationnovelI531V0.48
COADchr1910166634Silentrs755151805G269G0.21
COADchr1910142052SilentNAG1079G0.29
COADchr1910148982Silentrs375136816D858D0.41
COADchr1910156448Missense_Mutationrs751093624E432K0.22
COADchr1910140276Silentrs772752543A1176A0.09
COADchr1910154710Missense_MutationnovelA554T0.57
COADchr1910160050Frame_Shift_DelnovelM337Wfs*80.2
COADchr1910151512SilentnovelD701D0.2
COADchr1910142113Missense_Mutationrs779489678R1059H0.22
COADchr1910173123SilentNAT229T0.17
COADchr1910182046Nonsense_MutationNAE38*0.33
COADchr1910156453Missense_MutationnovelN430S0.08
COADchr1910175577Missense_MutationnovelK188T0.07
COADchr1910143961Missense_MutationNAR958H0.33
COADchr1910135740Missense_MutationNAR1574Q0.19
COADchr1910162737Missense_Mutationrs775360871R297Q0.22
COADchr1910156448Missense_Mutationrs751093624E432K0.2
COADchr1910143959Missense_MutationNAP959S0.39
ESCAchr1910143861SilentnovelY991Y0.12
ESCAchr1910143843SilentnovelK997K0.43
ESCAchr1910159660Splice_RegionnovelF410F0.07
ESCAchr1910159970Intronnovel0.3
GBMchr1910154640Missense_MutationnovelL577Q0.2
GBMchr1910155050Missense_MutationnovelA484V0.12
GBMchr1910146358Missense_MutationnovelT947A0.38
GBMchr1910154908SilentnovelI531I0.15
GBMchr1910180810Nonsense_MutationnovelE65*0.15
GBMchr1910143777Missense_MutationnovelN1019K0.17
GBMchr1910155048Missense_MutationNAE485K0.03
GBMchr1910154963Missense_MutationnovelV513G0.06
GBMchr1910162692Missense_MutationnovelS312C0.07
GBMchr1910154659Missense_MutationnovelD571Y0.07
GBMchr1910166616Silentrs762073261D275D0.41
GBMchr1910140237SilentnovelE1189E0.22
GBMchr1910137909Missense_MutationnovelG1390W0.41
GBMchr1910154667Missense_MutationnovelG568A0.72
GBMchr1910154991Missense_MutationnovelE504Q0.21
GBMchr1910159687SilentnovelA401A0.06
HNSCchr1910137155SilentnovelY1457Y0.25
HNSCchr1910151541Missense_MutationnovelP692S0.21
HNSCchr1910138533Missense_MutationNAP1325S0.21
HNSCchr1910143945Silentrs150359172P963P0.15
HNSCchr1910154417Missense_MutationNAT616M0.42
HNSCchr1910138452Missense_MutationnovelS1352G0.19
HNSCchr1910139709SilentnovelR1289R0.32
HNSCchr1910138518Missense_MutationnovelP1330S0.2
HNSCchr1910160405Missense_MutationnovelR325L0.09
HNSCchr1910160011Splice_Regionnovel0.07
KICHchr1910135791Missense_MutationnovelQ1557R0.13
KIRCchr1910136209Missense_MutationNAH1507R0.08
KIRCchr1910151527Missense_MutationNAM696I0.16
KIRCchr1910141170Missense_MutationnovelK1094R0.07
KIRCchr1910139690Missense_MutationNAF1296L0.42
KIRPchr1910140056Frame_Shift_DelnovelS1250Pfs*310.21
LAMLchr1910149880Missense_MutationnovelD769G0.13
LGGchr1910194875Missense_MutationnovelR9W0.15
LGGchr1910140841Missense_MutationnovelL1139M0.36
LGGchr1910143881Missense_MutationnovelL985M0.14
LGGchr1910159734SilentnovelL386L0.4
LGGchr1910166634Silentrs755151805G269G0.47
LIHCchr1910175618Splice_RegionnovelG174G0.39
LIHCchr1910175619Splice_SitenovelX174_splice0.39
LIHCchr1910137948Missense_MutationNAV1377M0.36
LIHCchr1910137928Silentrs764029022A1383A0.4
LIHCchr1910140888Missense_MutationNAQ1123P0.44
LUADchr1910138542Missense_MutationNAE1322Q0.1
LUADchr1910143768Splice_RegionNAY1022Y0.37
LUADchr1910138496Frame_Shift_DelnovelH1332Gfs*100.18
LUADchr1910140872Silentrs564054594S1128S0.26
LUADchr1910155014Missense_MutationNAA496V0.08
LUADchr1910154452Missense_MutationnovelI604M0.07
LUADchr1910154939Missense_MutationnovelD521V0.24
LUADchr1910177315SilentNAT166T0.11
LUADchr1910146388Missense_MutationnovelD937Y0.41
LUADchr1910143950Frame_Shift_DelnovelE962Sfs*1710.07
LUADchr1910135733Splice_Regionnovel0.31
LUSCchr1910141148Missense_MutationNAN1101K0.14
LUSCchr1910173123SilentnovelT229T0.11
LUSCchr1910140870Missense_MutationNAE1129G0.34
LUSCchr1910154349Missense_MutationNAD639Y0.73
LUSCchr1910180559Missense_MutationnovelL79P0.37
LUSCchr1910154760Missense_MutationnovelP537L0.43
LUSCchr1910149599Missense_MutationnovelC798R0.44
OVchr1910160060Silentrs772293711T333T0.11
OVchr1910154347Missense_MutationnovelD639E0.06
OVchr1910154991Missense_MutationnovelE504Q0.05
OVchr1910154994Frame_Shift_DelnovelQ503Rfs*250.04
OVchr1910154698Missense_MutationnovelV558M0.14
OVchr1910159693Nonsense_MutationnovelY399*0.38
OVchr1910159689Missense_MutationnovelA401S0.05
OVchr1910154679Missense_MutationnovelY564C0.11
OVchr1910144027Intronnovel0.5
OVchr1910142098Missense_MutationnovelY1064C0.07
OVchr1910151521Missense_MutationnovelE698D0.06
OVchr1910154645SilentnovelI575I0.07
OVchr1910149571Missense_MutationnovelA807V0.06
OVchr1910154934Missense_MutationNAT523A0.48
OVchr1910140223Missense_MutationnovelL1194Q0.06
OVchr1910151450Missense_MutationnovelK722T0.03
OVchr1910154718Missense_MutationnovelL551Q0.04
OVchr1910151514Frame_Shift_InsnovelD701Tfs*870.11
OVchr1910180224Intronnovel0.1
PAADchr1910146380SilentNAV939V0.09
PRADchr1910154623Missense_MutationNAD583N0.19
PRADchr1910151426Missense_MutationNAR730H0.08
PRADchr1910180837Nonsense_MutationnovelE56*0.12
READchr1910137980Missense_MutationNAT1366M0.29
READchr1910156448Missense_Mutationrs751093624E432K0.22
READchr1910140132SilentNAP1224P0.27
READchr1910180861Frame_Shift_InsnovelL48Afs*160.11
READchr1910166606Missense_MutationnovelD279N0.17
READchr1910155048Missense_MutationNAE485K0.46
READchr1910173121Missense_Mutationrs771381056R230H0.41
READchr1910144081Intronnovel0.36
READchr1910143961Missense_MutationNAR958H0.31
READchr1910151422SilentNAI731I0.29
READchr1910156448Missense_Mutationrs751093624E432K0.21
READchr1910173131Missense_MutationNAS227A0.1
SARCchr1910148884Missense_MutationnovelK891I0.08
SARCchr1910141158Missense_MutationnovelD1098V0.31
SARCchr1910136268Silentrs372868127P1487P0.35
SARCchr1910177294Splice_RegionnovelK173K0.29
SKCMchr1910144047Intronnovel0.51
SKCMchr1910138533Missense_MutationNAP1325S0.14
SKCMchr1910140134Missense_MutationNAP1224S0.16
SKCMchr1910140167Nonsense_MutationnovelQ1213*0.34
SKCMchr1910180782Missense_MutationnovelS74F0.36
SKCMchr1910137109Missense_MutationNAR1473C0.45
SKCMchr1910154380Silentrs370444117F628F0.19
SKCMchr1910156480Missense_MutationNAP421L0.34
SKCMchr1910140278Missense_MutationNAA1176T0.43
SKCMchr1910141133Silentrs748574658P1106P0.19
SKCMchr1910154908SilentnovelI531I0.25
SKCMchr1910154909Missense_MutationnovelI531S0.26
SKCMchr1910154323SilentNAA647A0.19
SKCMchr1910140133Missense_MutationNAP1224L0.19
SKCMchr1910141134Missense_MutationnovelP1106L0.44
SKCMchr1910149657Splice_RegionnovelR778R0.48
SKCMchr1910175617Missense_MutationnovelP175S0.39
SKCMchr1910142165Missense_MutationNAL1042F0.41
SKCMchr1910149005Missense_MutationNAP851S0.15
SKCMchr1910137895Silentrs774626723S1394S0.11
SKCMchr1910149637Missense_MutationNAD785G0.1
SKCMchr1910143763Splice_Regionnovel0.09
SKCMchr1910140067Missense_MutationNAS1246F0.14
SKCMchr1910138532Missense_MutationNAP1325L0.15
SKCMchr1910137281Splice_SiteNAX1416_splice0.21
SKCMchr1910137130Missense_Mutationrs147984942R1466C0.28
SKCMchr1910149918SilentNAT756T0.23
SKCMchr1910137927SilentNAL1384L0.51
SKCMchr1910159847Missense_MutationNAD373N0.46
SKCMchr1910136139Silentrs572638597P1530P0.49
SKCMchr1910141180Missense_MutationNAA1091S0.31
SKCMchr1910138485SilentNAL1341L0.13
SKCMchr1910139745SilentNAS1277S0.68
SKCMchr1910143904Missense_MutationNAS977F0.09
SKCMchr1910140857SilentnovelE1133E0.45
SKCMchr1910140794SilentnovelG1154G0.3
SKCMchr1910159947Intronnovel0.18
SKCMchr1910143785Missense_Mutationrs144533539R1017W0.36
STADchr1910140837Missense_Mutationrs767421908R1140Q0.3
STADchr1910149508Missense_MutationNAI828T0.28
STADchr1910138510Silentrs751126457H1332H0.09
STADchr1910159910Missense_MutationNAK352E0.33
STADchr1910148969Missense_MutationnovelY863H0.07
STADchr1910166634Silentrs755151805G269G0.05
STADchr1910156496Missense_Mutationrs181300723H416Y0.19
STADchr1910180479Missense_Mutationrs759600542R106C0.44
STADchr1910148999Missense_MutationNAS853P0.36
STADchr1910156460Missense_MutationNAE428K0.28
STADchr1910138590Missense_MutationnovelV1306M0.14
STADchr1910140237Missense_MutationnovelE1189D0.36
STADchr1910149853Missense_MutationnovelR778M0.14
STADchr1910146477Missense_MutationNAI907T0.4
STADchr1910140113Missense_MutationNAG1231C0.08
STADchr1910160391Frame_Shift_InsnovelK330Qfs*350.24
STADchr1910151426Missense_MutationNAR730H0.21
STADchr1910137961Silentrs779701784S1372S0.29
STADchr1910154768SilentnovelT534T0.3
STADchr1910140103Missense_MutationNAR1234H0.16
STADchr1910135719Intronnovel0.3
STADchr1910137945Missense_MutationnovelR1378W0.19
STADchr1910140065SilentNAL1247L0.27
STADchr1910142201Missense_MutationNAS1030P0.13
STADchr1910173873Splice_RegionNAE211E0.22
STADchr1910142180Missense_Mutationrs370786558A1037T0.22
TGCTchr1910180555SilentnovelA80A0.13
TGCTchr1910143850Missense_MutationnovelR995Q0.24
TGCTchr1910149924Silentrs771365059A754A0.42
THCAchr1910151499Missense_MutationNAD706N0.1
UCECchr1910162738Missense_MutationnovelR297W0.27
UCECchr1910149930SilentnovelI752I0.21
UCECchr1910180852Missense_Mutationrs755995375E51K0.27
UCECchr1910143781Missense_MutationnovelV1018A0.23
UCECchr1910146445Missense_MutationnovelD918Y0.16
UCECchr1910143789Missense_MutationNAK1015N0.31
UCECchr1910151814Missense_MutationnovelA669S0.52
UCECchr19101335733'UTRnovel0.41
UCECchr1910154379Missense_MutationNAD629N0.48
UCECchr1910154935SilentnovelS522S0.05
UCECchr1910180852Missense_Mutationrs755995375E51K0.19
UCECchr1910180517Missense_MutationnovelE93V0.4
UCECchr1910140184Missense_Mutationrs757460628R1207H0.11
UCECchr1910143809Missense_MutationnovelP1009S0.09
UCECchr1910135658Intronnovel0.51
UCECchr1910139687Missense_Mutationrs767041788G1297S0.34
UCECchr1910140315Silentrs761140414T1163T0.3
UCECchr1910142091Missense_MutationnovelE1066D0.28
UCECchr1910166621Missense_Mutationrs200024502E274K0.41
UCECchr1910154600Silentrs780983040V590V0.33
UCECchr1910159753SilentNAQ379Q0.26
UCECchr1910155862Missense_MutationNAF479L0.41
UCECchr1910136273Missense_MutationNAD1486N0.09
UCECchr1910136261Missense_MutationnovelR1490W0.21
UCECchr1910149912SilentnovelE758E0.18
UCECchr1910160405Missense_MutationnovelR325H0.13
UCECchr19101335193'UTRnovel0.5
UCECchr1910143944Missense_Mutationrs757550838V964M0.08
UCECchr1910151434Silentrs762745449N727N0.11
UCECchr1910146410Silentrs539948794N929N0.44
UCECchr1910146421Missense_MutationnovelA926S0.1
UCECchr1910166615Missense_MutationnovelE276K0.39
UCECchr1910151492Missense_MutationnovelN708S0.32
UCECchr1910137998Missense_MutationnovelG1360D0.34
UCECchr1910155029Missense_MutationnovelP491H0.37
UCECchr1910151404Silentrs765090249A737A0.52
UCECchr1910175543Silentrs753493675D199D0.5
UCECchr1910136268SilentnovelP1487P0.38
UCECchr1910135848Missense_MutationnovelR1538H0.61
UCECchr1910151532Missense_MutationnovelA695T0.27
UCECchr1910156505Missense_MutationnovelY413H0.51
UCECchr1910142180Missense_Mutationrs370786558A1037T0.58
UCECchr1910146408Missense_MutationnovelG930D0.51
UCECchr1910146494Missense_MutationnovelE901D0.41
UCECchr1910154376Missense_MutationnovelT630A0.4
UCECchr1910154926Missense_MutationnovelE525D0.41
UCECchr1910136273Missense_MutationNAD1486N0.47
UCECchr1910136212Missense_MutationnovelR1506Q0.09
UCECchr1910134267Missense_MutationNAG1589D0.4
UCECchr1910155048Missense_MutationNAE485K0.35
UCECchr1910159891Missense_MutationNAQ358R0.1
UCECchr1910177316Missense_MutationNAT166I0.31
UCECchr1910180426SilentNAA123A0.4
UCECchr1910180530Missense_MutationnovelD89Y0.29
UCECchr1910138442Missense_MutationnovelT1355N0.25
UCECchr1910149892Missense_MutationnovelV765A0.42
UCECchr1910180454Missense_MutationnovelR114I0.47
UCECchr1910136219Missense_MutationnovelG1504R0.07
UCECchr1910168348Missense_MutationNAR246Q0.41
UCECchr1910180530Missense_MutationnovelD89Y0.18
UCECchr1910137271Missense_MutationnovelA1419T0.43
UCECchr1910139794Missense_Mutationrs774073234R1261Q0.1
UCECchr1910151512SilentnovelD701D0.44
UCECchr1910154739Missense_MutationnovelR544H0.4
UCECchr1910134260Missense_MutationnovelE1591D0.38
UCECchr1910146455SilentnovelL914L0.4
UCECchr1910140094Missense_MutationNAS1237L0.2
UCECchr1910134227Missense_MutationnovelE1602D0.43
UCECchr1910142203Missense_MutationnovelK1029T0.34
UCECchr1910136169Silentrs761534071D1520D0.09
UCECchr1910154301Missense_MutationnovelV655I0.42
UCECchr1910162730Silentrs373861581P299P0.25
UCECchr1910135539Intronnovel0.38
UCECchr1910154626Missense_MutationNAR582W0.33
UCECchr1910151463Frame_Shift_DelNAM718Cfs*590.38
UCECchr1910149470Missense_Mutationrs751754286E841K0.5
UCECchr19101336553'UTRrs3751753040.38
UCECchr1910180852Missense_Mutationrs755995375E51K0.36
UCECchr1910140093Silentrs201007703S1237S0.16
UCECchr1910151440SilentnovelK725K0.19
UCECchr1910154768SilentnovelT534T0.23
UCECchr1910155048Missense_MutationNAE485K0.34
UCECchr1910155925Missense_MutationNAL458I0.26
UCECchr1910156494Silentrs780223552H416H0.24
UCECchr1910162672Missense_Mutationrs200531080E319K0.15
UCECchr1910166615Missense_MutationnovelE276K0.38
UCECchr1910180388Missense_Mutationrs775139340R136H0.41
UCECchr1910180852Missense_Mutationrs755995375E51K0.25
UCECchr1910146410Silentrs539948794N929N0.17
UCECchr1910149627Silentrs755858168N788N0.72
UCECchr1910136267Missense_Mutationrs749413587A1488T0.3
UCECchr1910135848Missense_MutationnovelR1538H0.5
UCECchr1910173887Missense_Mutationrs780431940V207I0.44
UCECchr1910177304Missense_MutationnovelH170R0.28
UCECchr1910154674Missense_MutationNAE566K0.4
UCECchr1910156447Missense_MutationnovelE432V0.28
UCECchr1910156448Missense_Mutationrs751093624E432K0.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
READDEL0.09090.23023
THCADEL0.0140.10598

Survival Analysis
CancerP-value Q-value
THYM0.0028

Kaplan-Meier Survival Analysis

KIRC0.031

Kaplan-Meier Survival Analysis

STAD0.0069

Kaplan-Meier Survival Analysis

SARC0.029

Kaplan-Meier Survival Analysis

MESO0.00012

Kaplan-Meier Survival Analysis

ACC0.00015

Kaplan-Meier Survival Analysis

HNSC0.0083

Kaplan-Meier Survival Analysis

PRAD0.022

Kaplan-Meier Survival Analysis

KIRP0.0012

Kaplan-Meier Survival Analysis

CESC0.016

Kaplan-Meier Survival Analysis

READ0.029

Kaplan-Meier Survival Analysis

LAML0.034

Kaplan-Meier Survival Analysis

LIHC0.00066

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

UVM0.0094

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000130816 (Gene tree)
Gene ID
1786
Gene Symbol
DNMT1
Alias
MCMT|CXXC9|DNMT
Full Name
DNA methyltransferase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
97,942 bases
Position
chr19:10,133,345-10,231,286
Accession
2976
RBP type
non-canonical RBP
Summary
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21507353Dnmt1 structure and function.Prog Mol Biol Transl Sci2011Svedruzic ZMdoi: 10.1016/B978-0-12-387685-0.00006-8.
19728080The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines.Breast Cancer Res Treat2010 JulLicata LAdoi: 10.1007/s10549-009-0517-8
31002127LncRNA SNHG1 promotes liver cancer development through inhibiting p53 expression via binding to DNMT1.Eur Rev Med Pharmacol Sci2019 AprLi SJdoi: 10.26355/eurrev_201904_17550.
31190878LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1.Onco Targets Ther2019 May 16Kang Xdoi: 10.2147/OTT.S189468
24003239Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA.J Biol Chem2013 Oct 18Hoshina Sdoi: 10.1074/jbc.M113.492504
25512341The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.Cell Res2015 JanBao Xdoi: 10.1038/cr.2014.165
31058319PARTICLE - The RNA podium for genomic silencers.J Cell Physiol2019 NovO'Leary VBdoi: 10.1002/jcp.28739
18220765Mammalian cytosine DNA methyltransferase Dnmt1: enzymatic mechanism, novel mechanism-based inhibitors, and RNA-directed DNA methylation.Curr Med Chem2008Svedruzic ZM-
25444166Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice.Biol Psychiatry2015 Mar 15Dong Edoi: 10.1016/j.biopsych.2014.08.012
11335728A conserved 3'-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity.J Biol Chem2001 Jul 6Detich N-
30402841lncRNA HOXB-AS3 promotes hepatoma by inhibiting p53 expression.Eur Rev Med Pharmacol Sci2018 OctZhang XMdoi: 10.26355/eurrev_201810_16145.
30536843Long noncoding RNA ATB participates in the development of renal cell carcinoma by downregulating p53 via binding to DNMT1.J Cell Physiol2019 AugSong Cdoi: 10.1002/jcp.27957
30915752LncRNA LINC00673 inhibits p53 expression by interacting with EZH2 and DNMT1 in papillary thyroid carcinoma.Eur Rev Med Pharmacol Sci2019 MarMeng XFdoi: 10.26355/eurrev_201903_17249.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000591798DNMT1-224521--- (aa)--
ENST00000586667DNMT1-207714--- (aa)--
ENST00000590619DNMT1-221231-ENSP0000046806277 (aa)-K7ER10
ENST00000589538DNMT1-220559--- (aa)--
ENST00000340748DNMT1-2015408-ENSP000003457391616 (aa)-P26358
ENST00000592054DNMT1-225591-ENSP0000046835971 (aa)-K7ERQ1
ENST00000588913DNMT1-2141775-ENSP00000467125389 (aa)-K7ENW7
ENST00000586086DNMT1-205489--- (aa)--
ENST00000592342DNMT1-226636-ENSP0000046599394 (aa)-K7ELB1
ENST00000586588DNMT1-2063094--- (aa)--
ENST00000587197DNMT1-211809--- (aa)--
ENST00000591239DNMT1-222550--- (aa)--
ENST00000359526DNMT1-2025206-ENSP000003525161632 (aa)-P26358
ENST00000591764DNMT1-223341--- (aa)--
ENST00000589349DNMT1-218603--- (aa)--
ENST00000586799DNMT1-208672-ENSP0000046726055 (aa)-K7EP77
ENST00000589294DNMT1-217575--- (aa)--
ENST00000587604DNMT1-212513--- (aa)--
ENST00000592705DNMT1-2275215-ENSP0000046665789 (aa)-K7EMU8
ENST00000593049DNMT1-228534--- (aa)--
ENST00000585920DNMT1-204529--- (aa)--
ENST00000588952DNMT1-215841-ENSP00000467050119 (aa)-K7ENQ6
ENST00000589091DNMT1-216563--- (aa)--
ENST00000589351DNMT1-219672--- (aa)--
ENST00000586988DNMT1-210711-ENSP0000046495840 (aa)-K7EIZ6
ENST00000585843DNMT1-203911--- (aa)--
ENST00000586800DNMT1-209583-ENSP0000046555525 (aa)-K7EKC3
ENST00000588118DNMT1-213973-ENSP00000465223255 (aa)-K7EJL0
Gene Model
Click here to download ENSG00000130816's gene model file
Pathways
Pathway IDPathway NameSource
hsa00270Cysteine and methionine metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa05206MicroRNAs in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000130816Child Development Disorders, Pervasive4.2719400E-005-
ENSG00000130816Hydrochlorothiazide3E-623400010
ENSG00000130816Triglycerides3E-623400010
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000130816rs1170648271910224049GHigh light scatter reticulocyte count27863252[0.081-0.161] unit decrease0.1210407EFO_0007986
ENSG00000130816rs1170648271910224049GHigh light scatter reticulocyte percentage of red cells27863252[0.084-0.164] unit decrease0.1239822EFO_0007986
ENSG00000130816rs21169401910199716GThiazide-induced adverse metabolic effects in hypertensive patients23400010[11.4-28.02] mg/dL decrease19.71EFO_0005202|EFO_0004530
ENSG00000130816rs21169411910223767CPulse pressure28135244[0.14-0.3] unit decrease0.2198EFO_0005763
ENSG00000130816rs104092431910222312TMyeloid white cell count27863252[0.015-0.03] unit decrease0.02282543EFO_0007988
ENSG00000130816rs22889371910230236GReticulocyte fraction of red cells27863252[0.038-0.056] unit decrease0.04712367EFO_0007986
ENSG00000130816rs1406586661910228310TImmature fraction of reticulocytes27863252[0.029-0.047] unit decrease0.03780359EFO_0007986
ENSG00000130816rs104092431910222312TNeutrophil count27863252[0.015-0.029] unit decrease0.02207318EFO_0004833
ENSG00000130816rs104092431910222312TGranulocyte count27863252[0.014-0.029] unit decrease0.02169456EFO_0007987
ENSG00000130816rs104092431910222312TSum neutrophil eosinophil counts27863252[0.015-0.029] unit decrease0.02187366EFO_0004833|EFO_0004842
ENSG00000130816rs104092431910222312TSum basophil neutrophil counts27863252[0.015-0.029] unit decrease0.02189254EFO_0004833|EFO_0005090
ENSG00000130816rs104092431910222312?Systolic blood pressure30595370EFO_0006335
ENSG00000130816rs104092431910222312?Cardiovascular disease30595370EFO_0000319
ENSG00000130816rs21169421910223987TSystolic blood pressure30578418[0.15-0.28] mmHg increase0.2156EFO_0006335
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130816's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000130816DNMT110085.000ENSMUSG00000004099Dnmt110077.483Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-IEAProcess
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0003677DNA binding21873635.IBAFunction
GO:0003677DNA binding18754681.IDAFunction
GO:0003723RNA binding-IEAFunction
GO:0003886DNA (cytosine-5-)-methyltransferase activity21873635.IBAFunction
GO:0003886DNA (cytosine-5-)-methyltransferase activity21745816.IDAFunction
GO:0005515protein binding16357870.16983096.17673620.17934516.17972916.19282482.19450230.19798101.21151116.21745816.21947282.22094255.25544563.25753001.27728808.IPIFunction
GO:0005634nucleus16791210.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005657replication fork-IEAComponent
GO:0005721pericentric heterochromatin-IEAComponent
GO:0006306DNA methylation10888872.TASProcess
GO:0006325chromatin organization-IEAProcess
GO:0007265Ras protein signal transduction24623306.IMPProcess
GO:0008270zinc ion binding-IEAFunction
GO:0008327methyl-CpG binding-IEAFunction
GO:0009008DNA-methyltransferase activity18754681.IDAFunction
GO:0009008DNA-methyltransferase activity-TASFunction
GO:0010216maintenance of DNA methylation21873635.IBAProcess
GO:0010216maintenance of DNA methylation18754681.21745816.IDAProcess
GO:0010424DNA methylation on cytosine within a CG sequence21873635.IBAProcess
GO:0010628positive regulation of gene expression18413740.IMPProcess
GO:0010629negative regulation of gene expression27021683.IMPProcess
GO:0016458gene silencing-IEAProcess
GO:0043045DNA methylation involved in embryo development-IEAProcess
GO:0045814negative regulation of gene expression, epigenetic-TASProcess
GO:0051571positive regulation of histone H3-K4 methylation18413740.IMPProcess
GO:0051573negative regulation of histone H3-K9 methylation18413740.IMPProcess
GO:0071230cellular response to amino acid stimulus-IEAProcess
GO:0090116C-5 methylation of cytosine-IEAProcess
GO:0090309positive regulation of methylation-dependent chromatin silencing24623306.IMPProcess
GO:1904707positive regulation of vascular smooth muscle cell proliferation27021683.IMPProcess
GO:1905460negative regulation of vascular associated smooth muscle cell apoptotic process27021683.IMPProcess
GO:1905931negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching27021683.IMPProcess
GO:1990841promoter-specific chromatin binding24623306.IDAFunction
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