EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26301749	Dyskerin and TERC expression may condition survival in lung cancer patients.	Oncotarget	2015 Aug 28	Penzo M	-
20501855	Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation.	Cancer Res	2010 Jun 1	Montanaro L	doi: 10.1158/0008-5472.CAN-09-4024
18936525	Relationship between dyskerin expression and telomerase activity in human breast cancer.	Cell Oncol	2008	Montanaro L	-
18607840	Real-time PCR quantification of human DKC1 expression in colorectal cancer.	Acta Oncol	2008	Turano M	doi: 10.1080/02841860801898616.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chrX	154776187	Missense_Mutation	novel	R447W	0.38
ACC	chrX	154773224	Missense_Mutation	novel	P377H	0.41
ACC	chrX	154775014	Intron	novel		0.39
BLCA	chrX	154764916	Nonsense_Mutation	novel	K12*	0.15
BLCA	chrX	154767002	Missense_Mutation	NA	E152Q	0.16
BRCA	chrX	154764940	Missense_Mutation	novel	K20E	0.2
BRCA	chrX	154764921	Missense_Mutation	NA	H13Q	0.46
BRCA	chrX	154767343	Missense_Mutation	NA	E201K	0.11
BRCA	chrX	154776837	Silent	NA	K505K	0.17
CESC	chrX	154776226	Missense_Mutation	NA	P460S	0.11
CESC	chrX	154768657	Intron	novel		0.35
CESC	chrX	154765513	Frame_Shift_Del	novel	*W52Gfs5**	0.11	TruB_N
CESC	chrX	154776880	3'UTR	novel		0.19
COAD	chrX	154768424	Missense_Mutation	novel	S255G	0.71
COAD	chrX	154776241	Silent	novel	L465L	0.33
COAD	chrX	154776877	3'UTR	novel		0.09
COAD	chrX	154773200	Missense_Mutation	novel	V369A	0.08
COAD	chrX	154764937	Missense_Mutation	rs782010351	R19W	0.4
COAD	chrX	154765448	Missense_Mutation	novel	I30T	0.05
COAD	chrX	154773168	Silent	rs781915787	C358C	0.38
COAD	chrX	154769242	Missense_Mutation	novel	R283W	0.1
COAD	chrX	154762788	5'UTR	novel		0.73
COAD	chrX	154775269	Missense_Mutation	rs782117503	A445V	0.43
COAD	chrX	154775252	Silent	rs143207180	A439A	0.33
ESCA	chrX	154774639	Missense_Mutation	rs199422253	L398P	0.15
GBM	chrX	154773236	Missense_Mutation	NA	G381A	0.2
GBM	chrX	154775028	Intron	novel		0.38
GBM	chrX	154768539	Intron	novel		0.06
GBM	chrX	154766374	Missense_Mutation	NA	R141H	0.44
GBM	chrX	154776310	Missense_Mutation	NA	E488K	0.38
GBM	chrX	154770818	Silent	rs374103494	D325D	0.24
GBM	chrX	154776272	Missense_Mutation	novel	K475R	0.36
GBM	chrX	154769252	Frame_Shift_Ins	novel	*Y287Lfs11**	0.06
HNSC	chrX	154769197	Missense_Mutation	novel	D268N	0.08
HNSC	chrX	154776933	3'UTR	novel		0.29
HNSC	chrX	154776935	3'UTR	novel		0.29
HNSC	chrX	154766314	Missense_Mutation	novel	S121I	0.28
KIRC	chrX	154777076	3'UTR	novel		0.25
LAML	chrX	154775118	Intron	novel		0.47
LGG	chrX	154765975	Missense_Mutation	novel	K80N	0.3	TruB_N
LGG	chrX	154776224	Missense_Mutation	novel	P459H	0.45
LIHC	chrX	154762976	Missense_Mutation	novel	A4V	0.35
LIHC	chrX	154768430	Missense_Mutation	NA	K257E	0.9
LIHC	chrX	154775090	Intron	novel		0.78
LUAD	chrX	154768615	Intron	novel		0.26
LUAD	chrX	154768637	Intron	novel		0.33
LUAD	chrX	154768578	Intron	novel		0.22
LUAD	chrX	154768423	Missense_Mutation	NA	M254I	0.19
LUAD	chrX	154768652	Intron	novel		0.2
LUAD	chrX	154768658	Intron	novel		0.27
LUAD	chrX	154770879	Missense_Mutation	NA	A346T	0.22
LUAD	chrX	154769252	Missense_Mutation	NA	V286A	0.09
LUAD	chrX	154766237	Missense_Mutation	novel	D95E	0.19	TruB_N
LUAD	chrX	154765480	Nonsense_Mutation	NA	E41*	0.24
LUAD	chrX	154773231	Missense_Mutation	novel	K379N	0.13
LUAD	chrX	154764965	Missense_Mutation	novel	A28V	0.17
LUAD	chrX	154768653	Intron	novel		0.38
LUSC	chrX	154770797	Silent	novel	P318P	0.63
OV	chrX	154768352	Missense_Mutation	novel	V231L	0.19
PAAD	chrX	154766349	Missense_Mutation	novel	I133V	0.07
PAAD	chrX	154773139	Missense_Mutation	novel	L349I	0.06
PRAD	chrX	154766276	Missense_Mutation	NA	W108C	0.07
READ	chrX	154775266	Missense_Mutation	NA	T444I	0.16
SKCM	chrX	154768402	Silent	NA	R247R	0.14
SKCM	chrX	154769227	Missense_Mutation	NA	D278N	0.3
SKCM	chrX	154773237	Silent	rs782792193	G381G	0.1
SKCM	chrX	154769220	Silent	novel	N275N	0.77
SKCM	chrX	154767367	Missense_Mutation	NA	P209S	0.75
SKCM	chrX	154775245	Missense_Mutation	novel	V437A	0.41
SKCM	chrX	154768606	Intron	novel		0.34
SKCM	chrX	154775211	Missense_Mutation	NA	E426K	0.39
SKCM	chrX	154768568	Intron	novel		0.18
SKCM	chrX	154768628	Intron	novel		0.32
SKCM	chrX	154767294	Silent	NA	P184P	0.29
SKCM	chrX	154776844	Missense_Mutation	novel	E508K	0.11
STAD	chrX	154776859	Nonsense_Mutation	novel	S513*	0.13
STAD	chrX	154767342	Silent	rs781789313	Y200Y	0.58
STAD	chrX	154764937	Missense_Mutation	rs782010351	R19W	0.89
STAD	chrX	154767364	Missense_Mutation	rs374771308	D208N	0.28
STAD	chrX	154775048	Intron	novel		0.08
STAD	chrX	154774690	Missense_Mutation	novel	E415G	0.31
STAD	chrX	154768581	Intron	novel		0.14
STAD	chrX	154775087	Intron	rs199881721		0.44
STAD	chrX	154768397	Missense_Mutation	NA	L246I	0.27
STAD	chrX	154767041	Frame_Shift_Del	novel	*T167Pfs7**	0.21
THCA	chrX	154775249	Silent	NA	V438V	0.48
UCEC	chrX	154775240	Silent	rs189466923	P435P	0.39
UCEC	chrX	154762923	5'UTR	novel		0.44
UCEC	chrX	154766356	Missense_Mutation	NA	C135Y	0.4
UCEC	chrX	154775232	Missense_Mutation	NA	K433Q	0.24
UCEC	chrX	154766374	Missense_Mutation	NA	R141H	0.32
UCEC	chrX	154768563	Intron	novel		0.38
UCEC	chrX	154775075	Intron	NA		0.29
UCEC	chrX	154776809	Missense_Mutation	novel	T496I	0.21
UCEC	chrX	154774660	Missense_Mutation	rs782379748	T405I	0.51
UCEC	chrX	154775068	Intron	NA		0.06
UCEC	chrX	154767041	Missense_Mutation	NA	G165W	0.19
UCEC	chrX	154776901	3'UTR	novel		0.11
UCEC	chrX	154775106	Intron	novel		0.28
UCEC	chrX	154770802	Missense_Mutation	novel	V320A	0.13
UCEC	chrX	154776831	Missense_Mutation	novel	K503N	0.18
UCEC	chrX	154768326	Missense_Mutation	novel	A222V	0.03
UCEC	chrX	154769239	Missense_Mutation	novel	L282M	0.04
UCEC	chrX	154769218	Missense_Mutation	novel	N275Y	0.04
UCEC	chrX	154774670	Silent	novel	T408T	0.19
UCEC	chrX	154764915	Missense_Mutation	novel	K11N	0.14
UCEC	chrX	154766292	Missense_Mutation	novel	R114W	0.46
UCEC	chrX	154776911	3'UTR	novel		0.5
UCEC	chrX	154762951	5'UTR	rs373433875		0.29
UCEC	chrX	154773169	Missense_Mutation	rs199422249	D359N	0.37
UCEC	chrX	154776844	Nonsense_Mutation	novel	E508*	0.33
UCEC	chrX	154773197	Missense_Mutation	novel	R368I	0.52
UCEC	chrX	154765462	Nonsense_Mutation	novel	E35*	0.32
UCEC	chrX	154765449	Missense_Mutation	NA	I30M	0.37
UCEC	chrX	154770818	Silent	rs374103494	D325D	0.38
UCEC	chrX	154762831	5'UTR	novel		0.25
UCEC	chrX	154773146	Missense_Mutation	novel	T351N	0.42
UCEC	chrX	154776877	3'UTR	novel		0.45
UCEC	chrX	154774599	Splice_Region	novel		0.25
UCEC	chrX	154762944	5'UTR	rs782080949		0.35
UCEC	chrX	154766281	Missense_Mutation	NA	R110Q	0.36
UCEC	chrX	154770879	Missense_Mutation	NA	A346T	0.3
UCEC	chrX	154773181	Missense_Mutation	novel	V363I	0.32
UCEC	chrX	154775059	Intron	novel		0.17
UCEC	chrX	154768656	Intron	novel		0.14
UCEC	chrX	154769192	Missense_Mutation	NA	V266A	0.5
UCEC	chrX	154775034	Intron	NA		0.53
UCEC	chrX	154776266	Missense_Mutation	NA	S473I	0.33
UCEC	chrX	154773212	Missense_Mutation	NA	R373I	0.29
UCEC	chrX	154775240	Silent	rs189466923	P435P	0.73
UCEC	chrX	154776194	Missense_Mutation	novel	R449Q	0.4
UCEC	chrX	154765456	Missense_Mutation	rs372511229	A33T	0.35
UCEC	chrX	154765946	Missense_Mutation	novel	P71S	0.13	TruB_N
UCS	chrX	154776199	Missense_Mutation	novel	S451R	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1932	3.2002e-05
DLBC	AMP	0.1458	0.24013
HNSC	AMP	0.2069	0.0095371
KIRC	AMP	0.0436	0.12739
LIHC	AMP	0.1514	0.011319
LUSC	AMP	0.1776	0.08275
OV	AMP	0.3092	2.176e-06
PAAD	AMP	0.0761	0.041079
READ	AMP	0.1576	0.14805
STAD	AMP	0.1111	0.0021069
TGCT	DEL	0.0733	0.08422
THCA	DEL	0.006	0.21991
UCS	DEL	0.3036	0.063955

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.029	Kaplan-Meier Survival Analysis
SARC	0.0013	Kaplan-Meier Survival Analysis
MESO	0.00022	Kaplan-Meier Survival Analysis
ACC	0.028	Kaplan-Meier Survival Analysis
HNSC	0.00084	Kaplan-Meier Survival Analysis
PRAD	0.022	Kaplan-Meier Survival Analysis
LUSC	0.038	Kaplan-Meier Survival Analysis
BRCA	0.046	Kaplan-Meier Survival Analysis
ESCA	0.0026	Kaplan-Meier Survival Analysis
KIRP	0.00014	Kaplan-Meier Survival Analysis
READ	0.041	Kaplan-Meier Survival Analysis
UCEC	0.00014	Kaplan-Meier Survival Analysis
LIHC	0.00017	Kaplan-Meier Survival Analysis
LGG	0.00035	Kaplan-Meier Survival Analysis
LUAD	0.015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130826 (Gene tree)
Gene ID: 1736
Gene Symbol: DKC1
Alias: XAP101|dyskerin|NAP57|NOLA4|Cbf5|DKC
Full Name: dyskerin pseudouridine synthase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 14,948 bases
Position: chrX:154,762,742-154,777,689
Accession: 2890
RBP type: canonical RBP
Summary: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000478387	TruB_N	PF01509.18	3.9e-21	1	1
ENSP00000358563	TruB_N	PF01509.18	5e-21	1	1
ENSP00000395693	TruB_N	PF01509.18	1.6e-20	1	1
ENSP00000400542	TruB_N	PF01509.18	1.8e-19	1	1
ENSP00000358563	PUA	PF01472.20	1.3e-17	1	1
ENSP00000478387	PUA	PF01472.20	1.3e-17	1	1
ENSP00000478387	DKCLD	PF08068.12	8.1e-31	1	1
ENSP00000395693	DKCLD	PF08068.12	9.9e-31	1	1
ENSP00000400542	DKCLD	PF08068.12	1.2e-30	1	1
ENSP00000358563	DKCLD	PF08068.12	1.2e-30	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22117216	Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita.	EMBO J	2011 Nov 25	Li S	doi: 10.1038/emboj.2011.427.
27197171	MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.	Cancer Res	2016 Jun 15	O'Brien R	doi: 10.1158/0008-5472.CAN-15-0879
7798307	NAP57, a mammalian nucleolar protein with a putative homolog in yeast and bacteria.	J Cell Biol	1994 Dec	Meier UT	-
19744324	Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins.	BMC Evol Biol	2009 Sep 10	Donovan J	doi: 10.1186/1471-2148-9-229.
22426501	Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription.	Int J Mol Med	2012 Jun	Dieriks B	doi: 10.3892/ijmm.2012.937
24690175	Acute dyskerin depletion triggers cellular senescence and renders osteosarcoma cells resistant to genotoxic stress-induced apoptosis.	Biochem Biophys Res Commun	2014 Apr 18	Lin P	doi: 10.1016/j.bbrc.2014.03.114
24303026	Dyskerin localizes to the mitotic apparatus and is required for orderly mitosis in human cells.	PLoS One	2013 Nov 26	Alawi F	doi: 10.1371/journal.pone.0080805
29448111	In silico screening of proteins targeting circulating miRNAs for improved diagnosis of multiple myeloma.	Biochem Biophys Res Commun	2018 Mar 4	Suyal S	doi: 10.1016/j.bbrc.2018.02.103
29672884	Oxidatively Modified Protein-Disulfide Isomerase-Associated 3 Promotes Dyskerin Pseudouridine Synthase 1-Mediated Malignancy and Survival of Hepatocellular Carcinoma Cells.	Hepatology	2018 Nov	Ko E	doi: 10.1002/hep.30039
30931479	N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.	Nucleic Acids Res	2019 Jun 4	MacNeil DE	doi: 10.1093/nar/gkz233.
18358808	Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.	Cell	2008 Mar 21	Venteicher AS	doi: 10.1016/j.cell.2008.01.019.
26286192	Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles.	Nucleic Acids Res	2015 Sep 30	Lee JH	doi: 10.1093/nar/gkv844
27573912	H/ACA Box Small Nucleolar RNA 7A Promotes the Self-Renewal of Human Umbilical Cord Mesenchymal Stem Cells.	Stem Cells	2017 Jan	Zhang Y	doi: 10.1002/stem.2490

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000492372	DKC1-212	406	-	-	- (aa)	-	-
ENST00000426673	DKC1-204	843	-	ENSP00000407253	207 (aa)	-	H7C2Q2
ENST00000437719	DKC1-205	686	-	ENSP00000395693	229 (aa)	-	H7C0M1
ENST00000475423	DKC1-208	587	-	-	- (aa)	-	-
ENST00000413910	DKC1-203	851	-	ENSP00000400542	258 (aa)	-	C9IYT0
ENST00000481062	DKC1-210	819	-	-	- (aa)	-	-
ENST00000452771	DKC1-206	708	-	ENSP00000407325	169 (aa)	-	H7C2Q9
ENST00000473552	DKC1-207	656	-	-	- (aa)	-	-
ENST00000620277	DKC1-213	3079	-	ENSP00000478387	420 (aa)	-	O60832
ENST00000369550	DKC1-201	2577	-	ENSP00000358563	514 (aa)	-	O60832
ENST00000484317	DKC1-211	671	-	-	- (aa)	-	-
ENST00000412124	DKC1-202	670	-	ENSP00000389304	76 (aa)	-	H7BZF2
ENST00000475966	DKC1-209	902	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000130826's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130826's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130826	DKC1	99	87.317	ENSAPOG00000007799	dkc1	91	78.556	Acanthochromis_polyacanthus
ENSG00000130826	DKC1	99	99.512	ENSAMEG00000002776	DKC1	100	91.829	Ailuropoda_melanoleuca
ENSG00000130826	DKC1	99	88.835	ENSACIG00000022614	dkc1	89	82.284	Amphilophus_citrinellus
ENSG00000130826	DKC1	99	86.408	ENSAOCG00000013159	dkc1	93	77.119	Amphiprion_ocellaris
ENSG00000130826	DKC1	99	86.408	ENSAPEG00000002284	dkc1	93	78.373	Amphiprion_percula
ENSG00000130826	DKC1	99	88.350	ENSATEG00000013682	dkc1	79	84.729	Anabas_testudineus
ENSG00000130826	DKC1	99	90.244	ENSACAG00000015600	DKC1	77	85.268	Anolis_carolinensis
ENSG00000130826	DKC1	99	99.512	ENSANAG00000022732	DKC1	100	97.665	Aotus_nancymaae
ENSG00000130826	DKC1	99	87.379	ENSACLG00000015605	dkc1	94	77.609	Astatotilapia_calliptera
ENSG00000130826	DKC1	99	88.293	ENSAMXG00000017108	dkc1	87	79.266	Astyanax_mexicanus
ENSG00000130826	DKC1	99	99.512	ENSBTAG00000013045	DKC1	100	91.440	Bos_taurus
ENSG00000130826	DKC1	98	68.966	WBGene00010478	K01G5.5	98	65.068	Caenorhabditis_elegans
ENSG00000130826	DKC1	99	100.000	ENSCJAG00000004210	DKC1	100	98.835	Callithrix_jacchus
ENSG00000130826	DKC1	99	89.756	ENSCAFG00000009311	-	96	79.000	Canis_familiaris
ENSG00000130826	DKC1	99	98.568	ENSCAFG00000019620	-	97	90.711	Canis_familiaris
ENSG00000130826	DKC1	99	98.568	ENSCAFG00020008918	-	97	90.711	Canis_lupus_dingo
ENSG00000130826	DKC1	99	90.732	ENSCAFG00020009379	-	92	78.831	Canis_lupus_dingo
ENSG00000130826	DKC1	99	99.024	ENSCHIG00000017392	DKC1	100	91.440	Capra_hircus
ENSG00000130826	DKC1	99	99.024	ENSTSYG00000007681	DKC1	99	94.050	Carlito_syrichta
ENSG00000130826	DKC1	99	98.537	ENSCAPG00000003342	DKC1	99	94.253	Cavia_aperea
ENSG00000130826	DKC1	99	98.537	ENSCPOG00000008825	DKC1	97	94.567	Cavia_porcellus
ENSG00000130826	DKC1	100	98.062	ENSCCAG00000027418	DKC1	100	90.661	Cebus_capucinus
ENSG00000130826	DKC1	100	99.222	ENSCATG00000033602	DKC1	100	99.222	Cercocebus_atys
ENSG00000130826	DKC1	99	99.512	ENSCLAG00000000720	DKC1	100	94.094	Chinchilla_lanigera
ENSG00000130826	DKC1	100	99.416	ENSCSAG00000006706	DKC1	100	99.416	Chlorocebus_sabaeus
ENSG00000130826	DKC1	99	92.195	ENSCPBG00000005858	DKC1	93	87.045	Chrysemys_picta_bellii
ENSG00000130826	DKC1	99	82.039	ENSCING00000004599	-	85	73.077	Ciona_intestinalis
ENSG00000130826	DKC1	99	83.010	ENSCSAVG00000010047	-	96	74.596	Ciona_savignyi
ENSG00000130826	DKC1	100	99.416	ENSCANG00000027987	DKC1	100	99.416	Colobus_angolensis_palliatus
ENSG00000130826	DKC1	99	97.073	ENSCGRG00001014574	-	97	92.354	Cricetulus_griseus_chok1gshd
ENSG00000130826	DKC1	94	74.112	ENSCGRG00001016789	-	98	65.112	Cricetulus_griseus_chok1gshd
ENSG00000130826	DKC1	94	74.112	ENSCGRG00000014809	-	96	64.990	Cricetulus_griseus_crigri
ENSG00000130826	DKC1	99	97.073	ENSCGRG00000016075	-	97	92.354	Cricetulus_griseus_crigri
ENSG00000130826	DKC1	99	85.922	ENSCSEG00000012633	dkc1	93	80.822	Cynoglossus_semilaevis
ENSG00000130826	DKC1	99	87.805	ENSCVAG00000010155	dkc1	83	80.365	Cyprinodon_variegatus
ENSG00000130826	DKC1	99	87.317	ENSDARG00000016484	dkc1	79	86.181	Danio_rerio
ENSG00000130826	DKC1	99	97.561	ENSDNOG00000004218	DKC1	100	92.218	Dasypus_novemcinctus
ENSG00000130826	DKC1	100	95.736	ENSDORG00000013566	-	99	95.736	Dipodomys_ordii
ENSG00000130826	DKC1	99	76.585	FBgn0259937	Nop60B	92	67.943	Drosophila_melanogaster
ENSG00000130826	DKC1	99	93.795	ENSETEG00000016095	DKC1	99	87.373	Echinops_telfairi
ENSG00000130826	DKC1	99	74.561	ENSEBUG00000015962	dkc1	99	81.911	Eptatretus_burgeri
ENSG00000130826	DKC1	86	79.096	ENSEBUG00000016062	dkc1	93	65.236	Eptatretus_burgeri
ENSG00000130826	DKC1	99	98.091	ENSEASG00005007484	DKC1	100	91.221	Equus_asinus_asinus
ENSG00000130826	DKC1	99	98.091	ENSECAG00000023524	DKC1	100	91.221	Equus_caballus
ENSG00000130826	DKC1	99	95.610	ENSEEUG00000003323	DKC1	99	90.353	Erinaceus_europaeus
ENSG00000130826	DKC1	99	87.864	ENSELUG00000014538	dkc1	90	79.955	Esox_lucius
ENSG00000130826	DKC1	99	98.537	ENSFCAG00000006577	DKC1	100	92.023	Felis_catus
ENSG00000130826	DKC1	99	89.806	ENSFALG00000011496	DKC1	95	79.800	Ficedula_albicollis
ENSG00000130826	DKC1	99	98.058	ENSFDAG00000002516	DKC1	100	93.124	Fukomys_damarensis
ENSG00000130826	DKC1	99	87.379	ENSFHEG00000004627	dkc1	89	78.233	Fundulus_heteroclitus
ENSG00000130826	DKC1	99	86.341	ENSGMOG00000017277	dkc1	100	83.376	Gadus_morhua
ENSG00000130826	DKC1	99	89.320	ENSGALG00000005054	DKC1	85	85.586	Gallus_gallus
ENSG00000130826	DKC1	99	87.317	ENSGAFG00000011486	dkc1	74	80.455	Gambusia_affinis
ENSG00000130826	DKC1	99	87.317	ENSGACG00000004373	dkc1	96	88.754	Gasterosteus_aculeatus
ENSG00000130826	DKC1	99	92.195	ENSGAGG00000011330	DKC1	89	84.946	Gopherus_agassizii
ENSG00000130826	DKC1	100	100.000	ENSGGOG00000001045	DKC1	100	100.000	Gorilla_gorilla
ENSG00000130826	DKC1	99	87.317	ENSHBUG00000012436	dkc1	86	80.361	Haplochromis_burtoni
ENSG00000130826	DKC1	99	99.024	ENSHGLG00000000649	DKC1	100	93.230	Heterocephalus_glaber_female
ENSG00000130826	DKC1	99	99.024	ENSHGLG00100001153	DKC1	100	93.151	Heterocephalus_glaber_male
ENSG00000130826	DKC1	99	87.317	ENSHCOG00000021099	dkc1	86	80.499	Hippocampus_comes
ENSG00000130826	DKC1	99	86.893	ENSIPUG00000010309	dkc1	88	79.348	Ictalurus_punctatus
ENSG00000130826	DKC1	99	90.244	ENSSTOG00000011904	-	93	84.569	Ictidomys_tridecemlineatus
ENSG00000130826	DKC1	99	99.024	ENSSTOG00000001074	-	100	95.483	Ictidomys_tridecemlineatus
ENSG00000130826	DKC1	99	97.073	ENSSTOG00000020149	-	100	84.078	Ictidomys_tridecemlineatus
ENSG00000130826	DKC1	100	96.899	ENSJJAG00000010086	-	99	96.899	Jaculus_jaculus
ENSG00000130826	DKC1	71	75.000	ENSJJAG00000008207	-	96	70.588	Jaculus_jaculus
ENSG00000130826	DKC1	99	82.927	ENSKMAG00000008010	dkc1	92	76.321	Kryptolebias_marmoratus
ENSG00000130826	DKC1	99	87.317	ENSLBEG00000019122	dkc1	92	78.879	Labrus_bergylta
ENSG00000130826	DKC1	99	89.268	ENSLACG00000014025	DKC1	91	88.693	Latimeria_chalumnae
ENSG00000130826	DKC1	99	89.268	ENSLOCG00000013713	dkc1	88	84.174	Lepisosteus_oculatus
ENSG00000130826	DKC1	99	96.585	ENSLAFG00000000221	DKC1	97	91.751	Loxodonta_africana
ENSG00000130826	DKC1	100	99.222	ENSMFAG00000032398	DKC1	86	99.222	Macaca_fascicularis
ENSG00000130826	DKC1	100	99.416	ENSMMUG00000005768	DKC1	100	99.416	Macaca_mulatta
ENSG00000130826	DKC1	100	99.416	ENSMNEG00000034503	DKC1	100	99.416	Macaca_nemestrina
ENSG00000130826	DKC1	100	99.416	ENSMLEG00000034422	DKC1	100	99.416	Mandrillus_leucophaeus
ENSG00000130826	DKC1	99	88.350	ENSMAMG00000005427	dkc1	89	87.406	Mastacembelus_armatus
ENSG00000130826	DKC1	99	87.317	ENSMZEG00005014503	dkc1	86	80.587	Maylandia_zebra
ENSG00000130826	DKC1	99	89.320	ENSMGAG00000009238	DKC1	87	85.504	Meleagris_gallopavo
ENSG00000130826	DKC1	100	96.512	ENSMAUG00000016454	-	99	96.512	Mesocricetus_auratus
ENSG00000130826	DKC1	99	77.670	ENSMICG00000002818	-	99	84.783	Microcebus_murinus
ENSG00000130826	DKC1	99	97.561	ENSMICG00000038751	-	100	92.678	Microcebus_murinus
ENSG00000130826	DKC1	100	93.023	ENSMOCG00000001169	-	99	93.023	Microtus_ochrogaster
ENSG00000130826	DKC1	99	87.379	ENSMMOG00000020348	dkc1	87	85.965	Mola_mola
ENSG00000130826	DKC1	99	92.195	ENSMODG00000009243	DKC1	78	85.903	Monodelphis_domestica
ENSG00000130826	DKC1	99	87.805	ENSMALG00000009454	dkc1	85	80.135	Monopterus_albus
ENSG00000130826	DKC1	99	93.427	MGP_CAROLIEiJ_G0033191	Dkc1	100	92.568	Mus_caroli
ENSG00000130826	DKC1	99	97.561	ENSMUSG00000031403	Dkc1	99	96.512	Mus_musculus
ENSG00000130826	DKC1	99	97.561	MGP_PahariEiJ_G0031735	Dkc1	99	96.512	Mus_pahari
ENSG00000130826	DKC1	99	97.561	MGP_SPRETEiJ_G0034351	Dkc1	99	96.512	Mus_spretus
ENSG00000130826	DKC1	99	99.024	ENSMPUG00000016136	DKC1	93	90.730	Mustela_putorius_furo
ENSG00000130826	DKC1	99	92.363	ENSMLUG00000011918	DKC1	100	83.525	Myotis_lucifugus
ENSG00000130826	DKC1	100	96.512	ENSNGAG00000015724	-	99	96.512	Nannospalax_galili
ENSG00000130826	DKC1	99	88.350	ENSNBRG00000005638	dkc1	81	86.717	Neolamprologus_brichardi
ENSG00000130826	DKC1	100	99.611	ENSNLEG00000014323	DKC1	100	99.611	Nomascus_leucogenys
ENSG00000130826	DKC1	99	85.841	ENSMEUG00000001066	DKC1	96	81.900	Notamacropus_eugenii
ENSG00000130826	DKC1	87	89.617	ENSOPRG00000005248	DKC1	100	75.639	Ochotona_princeps
ENSG00000130826	DKC1	99	98.049	ENSODEG00000011816	-	91	93.978	Octodon_degus
ENSG00000130826	DKC1	100	98.062	ENSODEG00000000549	-	99	98.062	Octodon_degus
ENSG00000130826	DKC1	99	88.780	ENSONIG00000013889	dkc1	95	77.800	Oreochromis_niloticus
ENSG00000130826	DKC1	97	67.943	ENSOANG00000022295	-	95	64.223	Ornithorhynchus_anatinus
ENSG00000130826	DKC1	99	96.117	ENSOANG00000008713	-	96	87.420	Ornithorhynchus_anatinus
ENSG00000130826	DKC1	99	98.537	ENSOCUG00000012646	DKC1	100	92.816	Oryctolagus_cuniculus
ENSG00000130826	DKC1	99	86.893	ENSORLG00000018748	dkc1	89	78.097	Oryzias_latipes
ENSG00000130826	DKC1	99	86.829	ENSOMEG00000005786	dkc1	82	85.356	Oryzias_melastigma
ENSG00000130826	DKC1	99	98.049	ENSOGAG00000003399	DKC1	100	91.794	Otolemur_garnettii
ENSG00000130826	DKC1	99	99.024	ENSOARG00000003047	DKC1	100	90.467	Ovis_aries
ENSG00000130826	DKC1	100	99.611	ENSPPAG00000023820	DKC1	100	99.611	Pan_paniscus
ENSG00000130826	DKC1	99	98.537	ENSPPRG00000009104	DKC1	100	92.023	Panthera_pardus
ENSG00000130826	DKC1	99	98.537	ENSPTIG00000017469	DKC1	99	89.194	Panthera_tigris_altaica
ENSG00000130826	DKC1	100	100.000	ENSPTRG00000022449	DKC1	100	100.000	Pan_troglodytes
ENSG00000130826	DKC1	99	100.000	ENSPTRG00000043416	-	85	100.000	Pan_troglodytes
ENSG00000130826	DKC1	100	99.416	ENSPANG00000011978	DKC1	100	99.416	Papio_anubis
ENSG00000130826	DKC1	99	89.320	ENSPKIG00000008443	dkc1	91	81.050	Paramormyrops_kingsleyae
ENSG00000130826	DKC1	98	82.969	ENSPSIG00000013765	DKC1	86	92.997	Pelodiscus_sinensis
ENSG00000130826	DKC1	99	84.951	ENSPMGG00000004097	dkc1	82	75.615	Periophthalmus_magnuspinnatus
ENSG00000130826	DKC1	100	84.496	ENSPEMG00000013348	Dkc1	96	95.897	Peromyscus_maniculatus_bairdii
ENSG00000130826	DKC1	99	92.683	ENSPCIG00000016706	DKC1	76	87.090	Phascolarctos_cinereus
ENSG00000130826	DKC1	99	87.805	ENSPFOG00000018653	dkc1	86	80.952	Poecilia_formosa
ENSG00000130826	DKC1	99	87.805	ENSPLAG00000003272	dkc1	72	86.111	Poecilia_latipinna
ENSG00000130826	DKC1	99	87.805	ENSPMEG00000010413	dkc1	86	80.952	Poecilia_mexicana
ENSG00000130826	DKC1	99	88.350	ENSPREG00000004100	dkc1	78	86.398	Poecilia_reticulata
ENSG00000130826	DKC1	99	100.000	ENSPPYG00000020892	DKC1	100	99.804	Pongo_abelii
ENSG00000130826	DKC1	99	97.073	ENSPCAG00000015034	DKC1	73	94.370	Procavia_capensis
ENSG00000130826	DKC1	99	99.512	ENSPCOG00000026874	DKC1	100	94.747	Propithecus_coquereli
ENSG00000130826	DKC1	99	97.073	ENSPVAG00000009222	DKC1	97	90.342	Pteropus_vampyrus
ENSG00000130826	DKC1	99	87.379	ENSPNYG00000020063	dkc1	88	80.000	Pundamilia_nyererei
ENSG00000130826	DKC1	99	88.350	ENSPNAG00000005780	dkc1	82	84.988	Pygocentrus_nattereri
ENSG00000130826	DKC1	99	89.756	ENSRNOG00000055562	Dkc1	97	82.294	Rattus_norvegicus
ENSG00000130826	DKC1	100	99.416	ENSRBIG00000028457	DKC1	86	99.416	Rhinopithecus_bieti
ENSG00000130826	DKC1	100	99.416	ENSRROG00000044780	DKC1	100	99.416	Rhinopithecus_roxellana
ENSG00000130826	DKC1	98	67.980	YLR175W	-	88	66.509	Saccharomyces_cerevisiae
ENSG00000130826	DKC1	99	100.000	ENSSBOG00000033746	DKC1	100	98.641	Saimiri_boliviensis_boliviensis
ENSG00000130826	DKC1	99	92.683	ENSSHAG00000002463	DKC1	97	85.776	Sarcophilus_harrisii
ENSG00000130826	DKC1	99	87.805	ENSSFOG00015009585	dkc1	89	79.957	Scleropages_formosus
ENSG00000130826	DKC1	99	87.805	ENSSMAG00000002552	dkc1	95	75.502	Scophthalmus_maximus
ENSG00000130826	DKC1	99	87.805	ENSSDUG00000009963	dkc1	85	81.448	Seriola_dumerili
ENSG00000130826	DKC1	99	87.864	ENSSLDG00000019342	dkc1	92	80.813	Seriola_lalandi_dorsalis
ENSG00000130826	DKC1	99	95.610	ENSSARG00000001822	DKC1	96	83.402	Sorex_araneus
ENSG00000130826	DKC1	99	92.195	ENSSPUG00000018907	DKC1	86	84.615	Sphenodon_punctatus
ENSG00000130826	DKC1	99	86.408	ENSSPAG00000002585	dkc1	76	86.869	Stegastes_partitus
ENSG00000130826	DKC1	100	97.150	ENSSSCG00000012823	DKC1	100	90.857	Sus_scrofa
ENSG00000130826	DKC1	99	89.806	ENSTGUG00000006781	DKC1	100	81.681	Taeniopygia_guttata
ENSG00000130826	DKC1	99	87.864	ENSTRUG00000004413	dkc1	86	80.952	Takifugu_rubripes
ENSG00000130826	DKC1	99	88.835	ENSTNIG00000002582	dkc1	87	65.324	Tetraodon_nigroviridis
ENSG00000130826	DKC1	99	97.561	ENSTBEG00000011262	DKC1	100	92.857	Tupaia_belangeri
ENSG00000130826	DKC1	94	93.953	ENSTTRG00000008089	DKC1	74	91.803	Tursiops_truncatus
ENSG00000130826	DKC1	99	99.515	ENSUAMG00000022721	DKC1	95	94.678	Ursus_americanus
ENSG00000130826	DKC1	99	99.515	ENSUMAG00000016899	DKC1	93	98.417	Ursus_maritimus
ENSG00000130826	DKC1	80	98.519	ENSVPAG00000003259	-	65	100.000	Vicugna_pacos
ENSG00000130826	DKC1	99	92.683	ENSVVUG00000021671	-	91	74.498	Vulpes_vulpes
ENSG00000130826	DKC1	99	96.912	ENSVVUG00000020734	-	87	89.370	Vulpes_vulpes
ENSG00000130826	DKC1	99	88.780	ENSXETG00000032517	DKC1	85	82.727	Xenopus_tropicalis
ENSG00000130826	DKC1	99	87.864	ENSXCOG00000005498	dkc1	92	79.638	Xiphophorus_couchianus
ENSG00000130826	DKC1	99	87.805	ENSXMAG00000004919	dkc1	86	80.499	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	25219674.	IMP	Process
GO:0000495	box H/ACA snoRNA 3'-end processing	21873635.	IBA	Process
GO:0001650	fibrillar center	-	IDA	Component
GO:0003720	telomerase activity	12135483.	IDA	Function
GO:0003720	telomerase activity	23685356.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003723	RNA binding	18082603.20351177.22527283.	IPI	Function
GO:0005515	protein binding	16601202.16618814.18358808.19179534.19383767.21846770.23685356.24965446.25467444.26496610.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005697	telomerase holoenzyme complex	12135483.18082603.29695869.	IDA	Component
GO:0005697	telomerase holoenzyme complex	20351177.	TAS	Component
GO:0005730	nucleolus	10556300.	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006364	rRNA processing	10556300.	TAS	Process
GO:0006396	RNA processing	9590285.	TAS	Process
GO:0007004	telomere maintenance via telomerase	23685356.29695869.	IDA	Process
GO:0007004	telomere maintenance via telomerase	26950371.	IMP	Process
GO:0007004	telomere maintenance via telomerase	-	TAS	Process
GO:0009982	pseudouridine synthase activity	21873635.	IBA	Function
GO:0009982	pseudouridine synthase activity	25219674.	IMP	Function
GO:0031118	rRNA pseudouridine synthesis	21873635.	IBA	Process
GO:0031118	rRNA pseudouridine synthesis	-	TAS	Process
GO:0031120	snRNA pseudouridine synthesis	21873635.	IBA	Process
GO:0031429	box H/ACA snoRNP complex	21873635.	IBA	Component
GO:0031429	box H/ACA snoRNP complex	18082603.	IDA	Component
GO:0031429	box H/ACA snoRNP complex	22527283.	TAS	Component
GO:0032212	positive regulation of telomere maintenance via telomerase	-	IEA	Process
GO:0034513	box H/ACA snoRNA binding	18082603.	IPI	Function
GO:0051973	positive regulation of telomerase activity	25467444.	IMP	Process
GO:0070034	telomerase RNA binding	26950371.	IC	Function
GO:0070034	telomerase RNA binding	18082603.20351177.22527283.	IPI	Function
GO:0072589	box H/ACA scaRNP complex	22527283.	TAS	Component
GO:0090661	box H/ACA telomerase RNP complex	18082603.	IDA	Component
GO:0090661	box H/ACA telomerase RNP complex	22527283.	TAS	Component
GO:0090666	scaRNA localization to Cajal body	25467444.	IMP	Process
GO:0090669	telomerase RNA stabilization	25467444.26950371.	IMP	Process
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904872	regulation of telomerase RNA localization to Cajal body	26950371.	IMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	IMP	Process
GO:1990481	mRNA pseudouridine synthesis	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.