EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
16533424Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapy.Neoplasia2006 JanChekerov R-
19111388Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis.Cancer Lett2009 Apr 18Coss Adoi: 10.1016/j.canlet.2008.11.018
26617887Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively.Int J Clin Exp Pathol2015 Sep 1Huang H-
23398928Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer.J Transl Med2013 Feb 11de Resende MFdoi: 10.1186/1479-5876-11-36.
21435434Assessment of Topoisomerase II α status in breast cancer by quantitative PCR, gene expression microarrays, immunohistochemistry, and fluorescence in situ hybridization.Am J Pathol2011 AprRomero Adoi: 10.1016/j.ajpath.2010.12.042.
28231233Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese.Med Sci Monit2017 Feb 23Wang TL-
25237769TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.Oncotarget2014 Oct 15Li X-
12237772DNA topoisomerase I and II expression in drug resistant germ cell tumours.Br J Cancer2002 Sep 9Berney DM-
24624938Expression of topoisomerase II alpha, ki67, and p53 in primary non-muscle-invasive urothelial bladder carcinoma.J Immunoassay Immunochem2014Ben Abdelkrim Sdoi: 10.1080/15321819.2014.899254.
21506336[Topoisomerase IIalpha activity and tumor cell proliferation level from the degree of bromodeoxyuridine label in uterine body leiomyosarcoma].Arkh Patol2011 Jan-FebLazarev AF-
21614903The value of TOP2A, EZH2 and paxillin expression as markers of aggressive breast cancer: relationship with other prognostic factors.Eur J Gynaecol Oncol2011Panousis D-
26046674EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells.Sci Rep2015 Jun 5Li Ydoi: 10.1038/srep11009.
19539329Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy.J Urol2009 AugAlbadine Rdoi: 10.1016/j.juro.2009.03.078
21734419Tumor topoisomerase II alpha status and response to anthracycline-based neoadjuvant chemotherapy in breast cancer.Oncology2011Nikol??nyi Adoi: 10.1159/000329038
19019771Expression of human DNA Topoisomerase II-alpha in squamous cell carcinoma of the larynx and its correlation with clinicopathologic variables.Am J Clin Pathol2008 DecShvero Jdoi: 10.1309/AJCPROG61USKCBEI.
28692049Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53.Oncogene2017 Nov 2Senturk JCdoi: 10.1038/onc.2017.229
26867764A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification.BMC Cancer2016 Feb 11Tarpgaard LSdoi: 10.1186/s12885-016-2124-5.
21288332Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers.Breast Cancer Res2011 Feb 2Lamy PJdoi: 10.1186/bcr2824.
24388441Higher expression of topoisomerase II alpha is an independent marker of increased risk of cancer-specific death in patients with clear cell renal cell carcinoma.Eur Urol2014 NovParker ASdoi: 10.1016/j.eururo.2013.12.017
22374418Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?Clin Transl Oncol2012 MarRomero Adoi: 10.1007/s12094-012-0779-1.
16864174TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer.Acta Oncol2006Villman K-
19270648Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis.Mod Pathol2009 AprFaggad Adoi: 10.1038/modpathol.2009.14
19913893Clinical implications and prognostic values of topoisomerase-II alpha expression in primary non-muscle-invasive bladder cancer.Urology2010 JunKim EJdoi: 10.1016/j.urology.2009.08.055
19729798Metastatic breast cancer survival according to HER2 and Topo2a gene status.Dis Markers2009Todorovi-Rakovi Ndoi: 10.3233/DMA-2009-0628.
16271071Characterization of human NSCLC cell line with innate etoposide-resistance mediated by cytoplasmic localization of topoisomerase II alpha.Cancer Sci2005 Novde Lucio B-
26588239Evaluation of TOP2A as a Predictive Marker for Endometrial Cancer With Taxane-Containing Adjuvant Chemotherapy.Int J Gynecol Cancer2016 FebIto Fdoi: 10.1097/IGC.0000000000000607.
28079792Amplification of HER2 and TOP2A and deletion of TOP2A genes in a series of Taiwanese breast cancer.Medicine (Baltimore)2017 JanChen JRdoi: 10.1097/MD.0000000000005582.
24675496Topoisomerase II alpha and microtubule-associated protein-tau as a predictive marker in axillary lymph node positive breast cancer.Tumori2014 Jan-FebWon HSdoi: 10.1700/1430.15820.
14991576Coamplified and overexpressed genes at ERBB2 locus in gastric cancer.Int J Cancer2004 Apr 20Varis A-
24682655HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: associations with patient and tumor characteristics.Breast Cancer Res Treat2014 MayFasching PAdoi: 10.1007/s10549-014-2922-x
21667123ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer.Breast Cancer Res Treat2012 AprJensen JDdoi: 10.1007/s10549-011-1610-3
25846735Clinical significance of topoisomerase 2A expression and gene change in operable invasive breast cancer.Tumour Biol2015 SepQiao JHdoi: 10.1007/s13277-015-3390-6
21629784A tri-marker proliferation index predicts biochemical recurrence after surgery for prostate cancer.PLoS One2011Malhotra Sdoi: 10.1371/journal.pone.0020293
22076611DNA topoisomerase II alpha: a favorable prognostic factor in colorectal caner.Int J Colorectal Dis2012 AprGao XHdoi: 10.1007/s00384-011-1346-x
27175798Immunocytochemical study of TOP2A and Ki-67 in cervical smears from women under routine gynecological care.J Biomed Sci2016 May 12Peres ALdoi: 10.1186/s12929-016-0258-z.
22426810Prognostic value of TOP2A gene amplification and chromosome 17 polysomy in early breast cancer.Pathol Oncol Res2012 OctZaczek A-
18332872Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.Lab Invest2008 MayArriola Edoi: 10.1038/labinvest.2008.19
21875466[Correlation of TOP2A gene expression and survival of breast cancer patients].Zhonghua Zhong Liu Za Zhi2011 MayMeng H-
25304659Expression of multidrug resistance-associated proteins and their relation to postoperative individualized chemotherapy in gastric cancer.World J Surg Oncol2014 Oct 11Yu Pdoi: 10.1186/1477-7819-12-307.
22569122Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells.Neurosci Lett2012 Jun 19Hong Ydoi: 10.1016/j.neulet.2012.04.071
16234514retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group.J Clin Oncol2005 Oct 20Knoop AS-
21705665TOP2A amplification in the absence of that of HER-2/neu: toward individualization of chemotherapeutic practice in breast cancer.Oncologist2011Glynn RWdoi: 10.1634/theoncologist.2011-0071
14566826HER-2 and TOP2A coamplification in urinary bladder cancer.Int J Cancer2003 Dec 10Simon R-
20079182[Inhibition of Topo II alpha gene expression and reversing of drug resistance in multi-drug resistant epithelial ovarian cancer cells induced by RNA interference in vitro].Zhonghua Fu Chan Ke Za Zhi2009 SepHe J-
20441774Clinical evaluation of developed PCR-based method with hydrolysis probes for TOP2A copy number evaluation in breast cancer samples.Clin Biochem2010 JulZaczek Adoi: 10.1016/j.clinbiochem.2010.04.060
21455636Expressions of topoisomerase IIα and BCRP in metastatic cells are associated with overall survival in small cell lung cancer patients.Pathol Oncol Res2011 SepRijavec Mdoi: 10.1007/s12253-011-9370-2
25042383Topoisomerase II-alfa gene as a predictive marker of response to anthracyclines in breast cancer.Pathol Res Pract2014 OctAlmeida Ddoi: 10.1016/j.prp.2014.06.017
26560244Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression.PLoS One2015 Nov 11Schaefer-Klein JLdoi: 10.1371/journal.pone.0142327
24630889MCM2/TOP2A (ProExC) immunohistochemistry as a predictive marker in head and neck mucosal biopsies.Pathol Res Pract2014 JunJenson EGdoi: 10.1016/j.prp.2014.02.003
19661040A phase II trial of a neoadjuvant platinum regimen for locally advanced breast cancer: pathologic response, long-term follow-up, and correlation with biomarkers.Clin Breast Cancer2009 AugYerushalmi Rdoi: 10.3816/CBC.2009.n.027.
28075472Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways.Oncol Rep2017 FebYang Zdoi: 10.3892/or.2017.5358
18465341The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D.Acta Oncol2008Nielsen KVdoi: 10.1080/02841860801995396.
25846551Profiling cancer gene mutations in longitudinal epithelial ovarian cancer biopsies by targeted next-generation sequencing: a retrospective study.Ann Oncol2015 JulBeltrame Ldoi: 10.1093/annonc/mdv164
26252353RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients.Oncol Rep2015 OctXu YCdoi: 10.3892/or.2015.4183
25921160Sensitivity of gastric cancer cells to chemotherapy drugs in elderly patients and its correlation with cyclooxygenase-2 expression.Asian Pac J Cancer Prev2015Qiu ZQ-
18824850Somatostatin elevates topoisomerase II alpha and enhances the cytotoxic effect of doxorubicin on gallbladder cancer cells.Chemotherapy2008Quan ZWdoi: 10.1159/000158662
20130985Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer.Breast Cancer Res Treat2010 AprKonecny GEdoi: 10.1007/s10549-010-0744-z
25098819Adjusting breast cancer patient prognosis with non-HER2-gene patterns on chromosome 17.PLoS One2014 Aug 6Kotoula Vdoi: 10.1371/journal.pone.0103707
21519837Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial.Breast Cancer Res Treat2011 JulO'Malley FPdoi: 10.1007/s10549-011-1511-5
22706628TOP2A RNA expression and recurrence in estrogen receptor-positive breast cancer.Breast Cancer Res Treat2012 JulSparano JAdoi: 10.1007/s10549-012-2112-7
26022247Allelic imbalance at the HER2/TOP2A locus in breast cancer.Diagn Pathol2015 May 29Huijsmans CJdoi: 10.1186/s13000-015-0289-x.
24138107Underpinning the repurposing of anthracyclines towards colorectal cancer: assessment of topoisomerase II alpha gene copy number alterations in colorectal cancer.Scand J Gastroenterol2013 DecNygrd SBdoi: 10.3109/00365521.2013.848230
20089371The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracycline-based neoadjuvant chemotherapy.Pathol Res Pract2010 Mar 15Kawachi Kdoi: 10.1016/j.prp.2009.10.009
25550836Significance of multidrug resistance gene-related proteins in the postoperative chemotherapy of gastric cancer.Int J Clin Exp Pathol2014 Oct 15Yu P-
15375522Prognostic value of Topoisomerase II in female breast cancer.Oncol Rep2004 OctKoren R-
22555090Her-2/neu and topoisomerase IIα in advanced breast cancer: a comprehensive FISH analysis of 245 cases.Diagn Mol Pathol2012 JunEngelstaedter Vdoi: 10.1097/PDM.0b013e31823b6e43.
28393224Overexpression of p53 protein is a marker of poor prognosis in Mexican women with breast cancer.Oncol Rep2017 MayDimas-Gonz??lez Jdoi: 10.3892/or.2017.5553
27284123Clinicopathological Significance of the Proliferation Markers Ki67, RacGAP1, and Topoisomerase 2 Alpha in Breast Cancer.Int J Surg Pathol2016 Octahin Sdoi: 10.1177/1066896916653211
27558965RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.Nat Commun2016 Aug 25Guturi KKNdoi: 10.1038/ncomms12638.
29587760The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer.BMC Cancer2018 Mar 27An Xdoi: 10.1186/s12885-018-4170-7.
29330624Functional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancer.Breast Cancer Res Treat2018 AprNuncia-Cantarero Mdoi: 10.1007/s10549-017-4652-3
30132517DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride.Int J Oncol2018 NovLiu LMdoi: 10.3892/ijo.2018.4531
30760286TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers.J Ovarian Res2019 Feb 13Ghisoni Edoi: 10.1186/s13048-019-0492-6.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr17404179015'UTRnovel0.76
ACCchr1740404833SilentnovelF668F0.41
ACCchr1740398838Missense_MutationNAD1130H0.24
BLCAchr1740416787Missense_MutationnovelL44V0.15
BLCAchr1740411817Missense_MutationnovelV264E0.15
BLCAchr1740395527Missense_MutationNAE1245K0.14
BLCAchr1740399934Missense_MutationnovelS1045Y0.24
BLCAchr17404178485'UTRnovel0.5
BLCAchr1740408034Missense_MutationNAR478T0.32
BLCAchr1740392098Missense_MutationnovelE1368Q0.24
BLCAchr1740396309Missense_MutationnovelE1232K0.22
BLCAchr1740407581Missense_MutationNAR532C0.31
BLCAchr1740407998Frame_Shift_InsnovelI490Nfs*100.24
BLCAchr1740411404Missense_MutationNAD339N0.17
BLCAchr1740400346Missense_Mutationrs375158687T955A0.44
BLCAchr1740404449Missense_MutationnovelD697Y0.27
BRCAchr1740400366Missense_MutationNAE948G0.19
BRCAchr17403892393'UTRnovel0.13
BRCAchr1740406832Nonsense_MutationnovelK579Nfs*60.06
BRCAchr1740391635Missense_MutationnovelE1380K0.48
BRCAchr1740404868Missense_MutationnovelQ657E0.08
BRCAchr1740413201Missense_MutationNAF190L0.25
BRCAchr1740396359Missense_Mutationrs777230505R1215H0.07
BRCAchr1740396339Nonsense_Mutationrs572906357R1222*0.4
BRCAchr1740400955SilentNAA853A0.21
CESCchr1740406633Missense_MutationNAW598C0.24
CESCchr1740413484SilentnovelV158V0.42
CESCchr1740398569Nonsense_MutationnovelE1176*0.25
CESCchr1740391536Frame_Shift_InsnovelN1413Vfs*110.2
CESCchr1740400368Frame_Shift_InsnovelE948Afs*80.13
CESCchr1740416033Frame_Shift_InsnovelM102Efs*151
CESCchr1740400565SilentNAI921I0.14
CESCchr1740406597SilentNAV610V0.21
CESCchr1740400307Frame_Shift_DelnovelK967Nfs*70.15
CESCchr1740389612SilentnovelD1501D0.3
CESCchr1740416864Missense_MutationnovelI18K0.25
CESCchr1740391558SilentnovelI1405I0.27
CESCchr1740391629Missense_MutationNAD1382H0.43
CESCchr17404179125'UTRnovel0.47
CHOLchr1740416750Nonsense_MutationnovelL56*0.21
CHOLchr1740396411Missense_MutationnovelG1198R0.11
CHOLchr1740417788Missense_MutationnovelE2K0.43
COADchr1740395535Missense_MutationNAE1242G0.31
COADchr1740396310SilentNAA1231A0.21
COADchr1740413246SilentNAT175T0.23
COADchr1740396390Frame_Shift_DelNAT1205Hfs*190.14
COADchr1740392682Missense_MutationnovelK1289N0.22
COADchr1740412816Silentrs375155672Y244Y0.26
COADchr1740416067Splice_RegionnovelV90V0.28
COADchr1740396408Frame_Shift_InsnovelK1199Efs*110.23
COADchr1740389983Silentrs567461017S1483S0.42
COADchr1740390049Missense_MutationNAK1461N0.34
COADchr1740398574Missense_MutationnovelF1174C0.08
COADchr1740411699Missense_Mutationrs200471658M303I0.07
COADchr1740398902Silentrs544012355N1108N0.26
COADchr1740396390Frame_Shift_DelNAT1205Hfs*190.42
COADchr1740396379SilentNAA1208A0.08
COADchr1740399892Missense_Mutationrs778671394I1059T0.26
COADchr1740416033Frame_Shift_DelnovelM102Cfs*140.11
COADchr1740402919Missense_MutationnovelF807L0.06
COADchr1740416438SilentnovelI84I0.09
COADchr1740389521Frame_Shift_DelNA*1532K0.42
COADchr1740396390Frame_Shift_DelNAT1205Hfs*190.34
COADchr1740413494Missense_MutationNAE155V0.31
COADchr1740396390Frame_Shift_DelNAT1205Hfs*190.35
DLBCchr1740392697SilentnovelP1284P0.45
ESCAchr1740411151Missense_MutationnovelS387R0.38
ESCAchr1740406847SilentnovelI574I0.39
ESCAchr1740390120Missense_MutationnovelP1438S0.08
GBMchr1740389984Missense_Mutationrs777338287S1483L0.26
GBMchr1740416759Missense_MutationnovelS53Y0.2
GBMchr1740392075Silentrs559251838V1375V0.54
GBMchr1740400375Frame_Shift_InsnovelN945Ifs*140.05
HNSCchr1740416850Missense_MutationnovelD23H0.05
HNSCchr1740411768SilentnovelD280D0.1
HNSCchr1740400987Missense_MutationnovelP843S0.35
HNSCchr1740396433Missense_MutationnovelQ1190H0.09
HNSCchr1740401067Nonsense_MutationnovelL816Sfs*40.11
HNSCchr1740407986Missense_MutationnovelR494L0.37
HNSCchr1740403055Splice_SitenovelX762_splice0.25
HNSCchr1740412924SilentnovelP208P0.25
HNSCchr1740390075Missense_MutationnovelQ1453E0.37
KIRCchr1740389580Missense_MutationNAS1512F0.32
KIRCchr17404178225'UTRnovel0.42
KIRPchr1740406591Nonsense_MutationnovelY612*0.45
LAMLchr1740406678Frame_Shift_InsnovelN583Kfs*120.06
LGGchr1740389984Missense_Mutationrs777338287S1483L0.52
LGGchr1740406434Missense_Mutationrs750554230R635C0.34
LGGchr1740407662Missense_MutationnovelA505T0.33
LGGchr1740400332In_Frame_InsnovelE959delinsDKTNT0.11
LIHCchr1740400885Missense_MutationnovelR877W0.17
LIHCchr1740390110Missense_MutationnovelT1441N0.44
LIHCchr17403893563'UTRnovel0.4
LIHCchr1740412762SilentnovelL262L0.05
LIHCchr1740392605Missense_MutationnovelT1315K0.4
LIHCchr1740408119Nonsense_MutationnovelR450*0.19
LUADchr1740399934Missense_MutationNAS1045F0.1
LUADchr1740416482Missense_MutationnovelI70L0.5
LUADchr1740389639SilentNAK1492K0.09
LUADchr1740400566Missense_MutationNAI921T0.43
LUADchr1740411721Missense_MutationnovelR296K0.56
LUADchr1740408124Missense_MutationNAG448V0.27
LUADchr1740404403Missense_MutationNAE712V0.34
LUADchr1740406407Nonsense_MutationnovelE644*0.08
LUADchr1740392682Missense_MutationnovelK1289N0.15
LUADchr17404178165'UTRnovel0.28
LUADchr1740398779Missense_MutationNAN1149K0.23
LUSCchr1740406405Missense_MutationnovelE644D0.18
LUSCchr1740416878Missense_MutationNAM13I0.64
LUSCchr1740396410Missense_MutationnovelG1198E0.23
LUSCchr1740398876Missense_MutationNAS1117C0.12
LUSCchr1740416744Missense_MutationnovelT58N0.26
LUSCchr1740391601Missense_MutationnovelS1391F0.34
LUSCchr1740398772Frame_Shift_InsnovelE1152Rfs*250.31
LUSCchr1740417790Translation_Start_SitenovelM1?0.36
LUSCchr1740399910Missense_Mutationrs776759121R1053H0.25
MESOchr17404178675'UTRnovel0.42
MESOchr1740417783SilentnovelV3V0.57
MESOchr1740392668Missense_MutationnovelW1294L0.08
OVchr1740412956Missense_MutationnovelM198L0.14
OVchr1740412905Missense_MutationnovelT215P0.1
OVchr1740412941Frame_Shift_DelnovelE203Dfs*190.53
OVchr1740412935Frame_Shift_InsnovelE205Lfs*380.09
OVchr1740398597Missense_MutationNAL1166F0.16
OVchr1740412925Frame_Shift_InsnovelP208Rfs*180.03
OVchr1740412934Frame_Shift_DelnovelM204Nfs*340.15
OVchr1740412950Frame_Shift_InsnovelR200Wfs*440.04
OVchr1740412905Missense_MutationnovelT215P0.13
OVchr1740411356Missense_MutationNAQ355E0.8
OVchr1740411687SilentNAG307G0.62
OVchr1740412946In_Frame_DelnovelR200_A201del0.04
OVchr1740403034SilentnovelI768I0.09
OVchr1740412936In_Frame_DelnovelM204del0.28
OVchr1740412961Frame_Shift_InsnovelD196Gfs*450.45
OVchr1740412905Missense_MutationnovelT215P0.41
OVchr1740412968Frame_Shift_DelnovelT193Gfs*450.05
OVchr1740412931Frame_Shift_DelnovelG202Qfs*160.35
OVchr1740390015Missense_MutationNAD1473Y0.32
OVchr1740412905Missense_MutationnovelT215P0.27
OVchr1740412925Missense_MutationnovelP208L0.03
OVchr1740390052SilentnovelT1460T0.14
OVchr1740412936Frame_Shift_DelnovelE203Nfs*340.18
PAADchr1740398880Missense_MutationnovelD1116N0.5
PAADchr1740408529Missense_MutationnovelI435M0.03
PRADchr1740400881Missense_Mutationrs548652478R878H0.18
PRADchr1740398875SilentNAS1117S0.12
PRADchr1740392637Silentrs190200755D1304D0.31
PRADchr1740408100Missense_MutationnovelT456M0.59
READchr1740392298Missense_Mutationrs563013978F1336L0.2
READchr1740400007Missense_MutationNAD1021Y0.43
READchr1740407998Missense_MutationNAI490T0.2
READchr1740400562Missense_MutationNAE922D0.15
READchr1740399965Nonsense_MutationNAE1035*0.4
READchr1740404255Missense_MutationnovelR727I0.04
READchr1740412779Missense_MutationNAL257F0.29
READchr1740389635Nonsense_MutationNAE1494*0.43
READchr1740399965Nonsense_MutationNAE1035*0.38
SARCchr1740395534Missense_MutationnovelE1242D0.2
SKCMchr1740406434Missense_Mutationrs750554230R635C0.38
SKCMchr1740400021Nonsense_MutationnovelL1016*0.2
SKCMchr1740417778Missense_MutationNAP5L0.14
SKCMchr1740412802Missense_MutationnovelS249F0.55
SKCMchr1740411806Missense_MutationNAR268C0.29
SKCMchr1740411201Missense_MutationnovelP371S0.21
SKCMchr1740411379Missense_MutationNAG347D0.34
SKCMchr1740400986Missense_MutationnovelP843L0.28
SKCMchr1740392328SilentnovelF1326F0.44
SKCMchr1740400921Missense_MutationNAP865S0.29
SKCMchr1740400922SilentnovelI864I0.12
SKCMchr1740400660Missense_MutationnovelP890S0.31
SKCMchr1740416471SilentNAR73R0.33
SKCMchr17404178295'UTRnovel0.36
SKCMchr1740406842Missense_MutationNAP576L0.33
SKCMchr1740390079SilentNAV1451V0.45
SKCMchr1740404168Missense_MutationNAS756F0.31
SKCMchr1740400307Missense_MutationNAF968L0.23
SKCMchr1740411754Missense_MutationNAS285F0.24
SKCMchr1740406614Missense_MutationnovelH605Y0.2
SKCMchr1740406605Missense_MutationnovelW608R0.49
SKCMchr1740396332Missense_MutationnovelT1224I0.83
SKCMchr1740411791Missense_MutationNAM273V0.25
SKCMchr1740392618Missense_MutationnovelP1311S0.74
SKCMchr1740398876Missense_MutationNAS1117F0.38
SKCMchr1740400296SilentnovelK971K0.14
STADchr1740404206Missense_MutationNAK743N0.11
STADchr1740396390Frame_Shift_DelNAT1205Hfs*190.24
STADchr1740390129Frame_Shift_Delrs758129598R1435Gfs*130.46
STADchr1740396390Frame_Shift_DelNAT1205Hfs*190.28
STADchr1740390129Frame_Shift_Delrs758129598R1435Gfs*130.49
STADchr1740406679Frame_Shift_DelnovelN583Tfs*490.2
STADchr1740392279Frame_Shift_DelnovelT1343Lfs*270.32
STADchr1740396390Frame_Shift_DelNAT1205Hfs*190.24
STADchr1740404206Missense_MutationNAK743N0.39
STADchr1740404206Missense_MutationNAK743N0.26
STADchr1740390151SilentNAT1427T0.55
STADchr1740390129Frame_Shift_Delrs758129598R1435Gfs*130.39
STADchr1740392637Silentrs190200755D1304D0.3
STADchr1740396423Missense_MutationnovelP1194T0.38
STADchr1740406383Splice_SiteNAX651_splice0.18
STADchr1740400343Nonsense_MutationnovelD956Ifs*80.14
STADchr1740390129Frame_Shift_Delrs758129598R1435Gfs*130.19
STADchr1740390129Frame_Shift_Delrs758129598R1435Gfs*130.35
STADchr1740400882Missense_Mutationrs371274856R878C0.25
UCECchr1740392679SilentNAK1290K0.32
UCECchr1740411119Missense_MutationNAF398C0.36
UCECchr1740413287Nonsense_MutationNAR162*0.35
UCECchr1740399965Nonsense_MutationNAE1035*0.34
UCECchr1740398566Missense_MutationNAE1177K0.39
UCECchr1740407595Nonsense_MutationNAS527*0.05
UCECchr1740413194Splice_SitenovelX192_splice0.33
UCECchr1740398901Missense_MutationNAE1109K0.48
UCECchr1740399897Missense_MutationnovelE1057D0.06
UCECchr1740400907SilentnovelV869V0.4
UCECchr1740408511Silentrs760972440L441L0.38
UCECchr17403892263'UTRnovel0.16
UCECchr1740407580Missense_MutationNAR532H0.29
UCECchr1740401008Missense_MutationnovelV836I0.51
UCECchr1740413241Missense_MutationnovelF177C0.17
UCECchr1740400559SilentNAI923I0.16
UCECchr1740408005Nonsense_MutationNAG488*0.2
UCECchr1740389635Frame_Shift_DelnovelE1494Rfs*260.07
UCECchr1740416822Missense_MutationNAR32I0.43
UCECchr17403889433'UTRnovel0.2
UCECchr1740406423SilentNAF638F0.34
UCECchr1740413490Missense_MutationnovelK156N0.49
UCECchr1740390086Missense_MutationnovelS1449F0.38
UCECchr1740400021Missense_MutationNAL1016S0.23
UCECchr1740390142Silentrs746498940T1430T0.39
UCECchr1740392637Silentrs190200755D1304D0.34
UCECchr1740411721Missense_MutationnovelR296K0.19
UCECchr1740392098Nonsense_MutationnovelE1368*0.31
UCECchr1740389984Missense_Mutationrs777338287S1483L0.38
UCECchr1740396304Missense_Mutationrs1141364K1233N0.45
UCECchr1740399919Missense_MutationnovelN1050T0.11
UCECchr1740406439Missense_MutationnovelR633I0.38
UCECchr1740416430Missense_MutationnovelE87G0.48
UCECchr1740390129Frame_Shift_Delrs758129598R1435Gfs*130.39
UCECchr1740398868Missense_MutationnovelD1120Y0.45
UCECchr1740399956Missense_MutationnovelL1038I0.29
UCECchr1740413287Nonsense_MutationNAR162*0.37
UCECchr1740389984Missense_Mutationrs777338287S1483L0.25
UCECchr17403895093'UTRrs7537426430.11
UCECchr1740396296Missense_MutationnovelK1236T0.25
UCECchr1740400007Missense_MutationNAD1021Y0.37
UCECchr1740406461Nonsense_MutationnovelE626*0.47
UCECchr1740400365Missense_MutationnovelE948D0.18
UCECchr1740404814Nonsense_MutationnovelR675*0.13
UCECchr1740417778Missense_MutationNAP5L0.32
UCECchr1740395483Frame_Shift_DelnovelK1259Nfs*40.22
UCECchr1740398824Missense_MutationnovelW1134C0.17
UCECchr1740390151SilentnovelT1427T0.5
UCECchr1740398868Missense_MutationnovelD1120Y0.41
UCECchr1740389984Missense_Mutationrs777338287S1483L0.22
UCECchr1740396390Frame_Shift_DelNAT1205Hfs*190.19
UCECchr1740392682Missense_MutationnovelK1289N0.11
UCECchr1740404882Missense_MutationnovelA652V0.29
UCECchr1740412864Missense_MutationNAM228I0.1
UCECchr1740398558Missense_MutationnovelE1179D0.09
UCECchr1740403013SilentnovelF775F0.42
UCECchr17404178585'UTRNA0.48
UCECchr1740390105SilentNAR1443R0.53
UCECchr1740400894Missense_MutationNAN874H0.3
UCECchr1740389635Frame_Shift_DelnovelE1494Rfs*260.39
UCECchr1740399114Nonsense_MutationNAE1072*0.2
UCECchr17403894493'UTRnovel0.5
UCECchr1740398632SilentnovelL1155L0.19
UCECchr1740400381Missense_MutationnovelM943T0.21
UCECchr1740403055Splice_SitenovelX762_splice0.43
UCECchr1740406851Missense_MutationnovelF573C0.22
UCECchr1740390125Missense_MutationnovelA1436V0.3
UCECchr1740408622Silentrs756124316G404G0.28
UCECchr17404178585'UTRNA0.32
UCECchr1740396379SilentNAA1208A0.25
UCECchr1740398835Missense_MutationnovelM1131V0.39
UCECchr1740404833Missense_MutationnovelF668L0.5
UCECchr1740406461Nonsense_MutationnovelE626*0.42
UCECchr1740398902Silentrs544012355N1108N0.36
UCSchr1740404255Missense_MutationnovelR727I0.06

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.27780.0017784
DLBCDEL00.18166
THCADEL0.0020.221
UCSDEL0.35710.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
THYM0.0035

Kaplan-Meier Survival Analysis

KIRC0.00017

Kaplan-Meier Survival Analysis

SARC0.0016

Kaplan-Meier Survival Analysis

MESO0.00021

Kaplan-Meier Survival Analysis

ACC0.00019

Kaplan-Meier Survival Analysis

SKCM0.026

Kaplan-Meier Survival Analysis

LUSC0.036

Kaplan-Meier Survival Analysis

KIRP0.00011

Kaplan-Meier Survival Analysis

COAD0.0022

Kaplan-Meier Survival Analysis

PAAD0.00012

Kaplan-Meier Survival Analysis

PCPG0.042

Kaplan-Meier Survival Analysis

READ0.0078

Kaplan-Meier Survival Analysis

KICH0.0026

Kaplan-Meier Survival Analysis

UCEC0.011

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

CHOL0.029

Kaplan-Meier Survival Analysis

LUAD0.00043

Kaplan-Meier Survival Analysis

UVM0.029

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000131747 (Gene tree)
Gene ID
7153
Gene Symbol
TOP2A
Alias
TOP2
Full Name
DNA topoisomerase II alpha
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
29,435 bases
Position
chr17:40,388,516-40,417,950
Accession
11989
RBP type
non-canonical RBP
Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18820297Regulation of the catalytic function of topoisomerase II alpha through association with RNA.Nucleic Acids Res2008 NovPark SWdoi: 10.1093/nar/gkn614
21768308Translational control of TOP2A influences doxorubicin efficacy.Mol Cell Biol2011 SepSrikantan Sdoi: 10.1128/MCB.05639-11
3037524RepA and DnaA proteins are required for initiation of R1 plasmid replication in vitro and interact with the oriR sequence.Proc Natl Acad Sci U S A1987 JulMasai H-
9588897Nucleolar function and size in cancer cells.Am J Pathol1998 MayDerenzini M-
9211974Relative distribution of rDNA and proteins of the RNA polymerase I transcription machinery at chromosomal NORs.Chromosoma1997 JunSuja JA-
24667787Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.Eur J Hum Genet2015 JanXia Qdoi: 10.1038/ejhg.2014.48
16427078Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells.J Mol Biol2006 Mar 17Khobta A-
6098156Enzyme studies of replication of the Escherichia coli chromosome.Adv Exp Med Biol1984Kornberg A-
9720989The phosphoprotein pp135 is an essential constituent of the fibrillar components of nucleoli and of coiled bodies.Histochem Cell Biol1998 AugVandelaer M-
9112231Antinuclear autoantibodies: probes for defining proteolytic events associated with apoptosis.Mol Biol Rep1996Casiano CA-
8083304Conformational information in DNA: its role in the interaction with DNA topoisomerase I and nucleosomes.J Cell Biochem1994 MayCaserta M-
17587596The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons.J Struct Biol2007 SepCasafont I-
21771901Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast.Proc Natl Acad Sci U S A2011 Aug 2Sperling ASdoi: 10.1073/pnas.1106834108
24187022Reclassification of Bifidobacterium stercoris Kim et al. 2010 as a later heterotypic synonym of Bifidobacterium adolescentis.Int J Syst Evol Microbiol2013 NovKiller Jdoi: 10.1099/ijs.0.054957-0.
23495154Structure-activity relationship of polypyridyl ruthenium(II) complexes as DNA intercalators, DNA photocleavage reagents, and DNA topoisomerase and RNA polymerase inhibitors.Chem Biodivers2013 MarChen Xdoi: 10.1002/cbdv.201100414.
28510215Species-specific supercoil dynamics of the bacterial nucleoid.Biophys Rev2016 NovHiggins NPdoi: 10.1007/s12551-016-0207-9
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000423485TOP2A-2015758XM_005257632ENSP000004115321531 (aa)XP_005257689P11388
ENST00000581055TOP2A-205579-ENSP00000462908147 (aa)-J3KTB7
ENST00000578412TOP2A-204882--- (aa)--
ENST00000577541TOP2A-202420-ENSP0000046405527 (aa)-J3QR57
ENST00000577706TOP2A-203554--- (aa)--
Gene Model
Click here to download ENSG00000131747's gene model file
Pathways
Pathway IDPathway NameSource
hsa01524Platinum drug resistanceKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000131747Hip9E-825673412
ENSG00000131747Hip1E-925673412
ENSG00000131747Body Mass Index1E-925673412
ENSG00000131747Hip3E-725673412
ENSG00000131747Body Mass Index3E-725673412
ENSG00000131747Hip4E-825673412
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000131747rs136951740388941THip circumference25673412[0.016-0.033] unit increase0.0242EFO_0005093
ENSG00000131747rs136951740388941THip circumference25673412[0.019-0.042] unit increase0.0304EFO_0005093
ENSG00000131747rs136951740388941THip circumference adjusted for BMI25673412[0.018-0.036] unit increase0.027EFO_0008039
ENSG00000131747rs136951740388941THip circumference adjusted for BMI25673412[0.018-0.04] unit increase0.0286EFO_0008039
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131747's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000131747TOP2A10095.238ENSMUSG00000020914Top2a9989.426Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000228nuclear chromosome9049244.IDAComponent
GO:0000287magnesium ion binding22323612.IDAFunction
GO:0000712resolution of meiotic recombination intermediates21873635.IBAProcess
GO:0000793condensed chromosome-IEAComponent
GO:0000819sister chromatid segregation21873635.IBAProcess
GO:0002244hematopoietic progenitor cell differentiation-IEAProcess
GO:0003677DNA binding9049244.10788521.12079377.IDAFunction
GO:0003682chromatin binding9049244.IDAFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity16611985.IDAFunction
GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity12711669.IMPFunction
GO:0005080protein kinase C binding16611985.IPIFunction
GO:0005515protein binding10788521.12711669.15965487.16611985.17983804.18790802.19390626.20457750.23652018.23698369.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus10788521.10959840.16611985.IDAComponent
GO:0005654nucleoplasm9049244.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus17567603.IDAComponent
GO:0005730nucleolus9049244.IDAComponent
GO:0005814centriole9049244.IDAComponent
GO:0006265DNA topological change22323612.IDAProcess
GO:0006265DNA topological change12711669.IMPProcess
GO:0006266DNA ligation15491148.IDAProcess
GO:0006974cellular response to DNA damage stimulus16611985.IDAProcess
GO:0007059chromosome segregation11136718.15456904.15965487.IMPProcess
GO:0007143female meiotic nuclear division-IEAProcess
GO:0008022protein C-terminus binding10666337.15965487.IPIFunction
GO:0008094DNA-dependent ATPase activity12079377.IDAFunction
GO:0008144drug binding16914642.IDAFunction
GO:0008301DNA binding, bending22323612.IDAFunction
GO:0009330DNA topoisomerase complex (ATP-hydrolyzing)10473615.IDAComponent
GO:0019035viral integration complex16712776.IMPComponent
GO:0019899enzyme binding10959840.17567603.IPIFunction
GO:0030263apoptotic chromosome condensation21873635.IBAProcess
GO:0030263apoptotic chromosome condensation10959840.IDAProcess
GO:0032991protein-containing complex16611985.IDAComponent
GO:0040016embryonic cleavage-IEAProcess
GO:0042752regulation of circadian rhythm-ISSProcess
GO:0042803protein homodimerization activity10473615.IPIFunction
GO:0042826histone deacetylase binding11062478.11136718.IPIFunction
GO:0043065positive regulation of apoptotic process16611985.IDAProcess
GO:0043130ubiquitin binding15965487.IMPFunction
GO:0044774mitotic DNA integrity checkpoint21873635.IBAProcess
GO:0045870positive regulation of single stranded viral RNA replication via double stranded DNA intermediate16712776.IMPProcess
GO:0045944positive regulation of transcription by RNA polymerase II-IEAProcess
GO:0046982protein heterodimerization activity10473615.IPIFunction
GO:0048511rhythmic process-IEAProcess
GO:1905463negative regulation of DNA duplex unwinding12711669.IMPProcess
GO:1990904ribonucleoprotein complex12711669.IDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us