EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	101286908	Splice_Region	novel	K153K	0.3
BLCA	chr15	101287678	Missense_Mutation	novel	L112F	0.18
BLCA	chr15	101286972	Missense_Mutation	novel	R132K	0.13
BLCA	chr15	101285749	Missense_Mutation	rs772297229	P198S	0.5
BRCA	chr15	101281622	3'UTR	novel		0.28
CESC	chr15	101292038	Missense_Mutation	rs776784734	R78H	0.24
CESC	chr15	101285056	Missense_Mutation	novel	A207V	0.09
CESC	chr15	101295100	Missense_Mutation	NA	R27W	0.34
CESC	chr15	101295106	Missense_Mutation	NA	D25N	0.34
COAD	chr15	101284966	Splice_Site	novel	X237_splice	0.31
COAD	chr15	101281767	Missense_Mutation	NA	G242V	0.24
COAD	chr15	101281768	Missense_Mutation	NA	G242C	0.24
COAD	chr15	101287682	Silent	novel	A110A	0.15
HNSC	chr15	101293027	Missense_Mutation	novel	I76M	0.19
HNSC	chr15	101281759	Missense_Mutation	novel	E245K	0.26
KIRC	chr15	101286978	Frame_Shift_Del	novel	*H130Lfs6**	0.04
KIRP	chr15	101286975	Missense_Mutation	novel	Y131C	0.31
KIRP	chr15	101293048	Silent	novel	L69L	0.26
LAML	chr15	101286232	Missense_Mutation	novel	I174N	0.23
LIHC	chr15	101287684	Missense_Mutation	NA	A110S	0.67
LUAD	chr15	101293048	Missense_Mutation	novel	L69F	0.64
LUAD	chr15	101285744	Silent	novel	G199G	0.61
LUSC	chr15	101292008	Missense_Mutation	NA	P88L	0.22
LUSC	chr15	101286972	Missense_Mutation	novel	R132K	0.08
MESO	chr15	101285007	Frame_Shift_Ins	novel	*L224Afs17**	0.31
PAAD	chr15	101281733	Silent	rs151201574	N253N	0.19
PRAD	chr15	101281777	Missense_Mutation	novel	T239P	0.3
PRAD	chr15	101291970	Missense_Mutation	rs369821067	V101M	0.26
SKCM	chr15	101285754	Missense_Mutation	NA	P196L	0.39
SKCM	chr15	101293161	Missense_Mutation	rs138801817	P32S	0.15
SKCM	chr15	101281753	Missense_Mutation	NA	E247K	0.38
STAD	chr15	101293075	Frame_Shift_Del	novel	*P61Lfs3**	0.2
STAD	chr15	101293030	Frame_Shift_Del	novel	*R75Nfs6**	0.19
STAD	chr15	101295164	Silent	NA	T5T	0.67
STAD	chr15	101293159	Silent	rs773545952	P32P	0.13
STAD	chr15	101293122	Missense_Mutation	novel	D45H	0.12
STAD	chr15	101281770	Missense_Mutation	NA	D241G	0.19
STAD	chr15	101291999	Missense_Mutation	NA	T91I	0.42
UCEC	chr15	101281631	3'UTR	novel		0.15
UCEC	chr15	101292039	Missense_Mutation	rs745867854	R78C	0.38
UCEC	chr15	101293077	Missense_Mutation	novel	F60V	0.42
UCEC	chr15	101293068	Silent	novel	L63L	0.32
UCEC	chr15	101281682	3'UTR	rs779598461		0.22
UCEC	chr15	101286262	Missense_Mutation	novel	G164D	0.08
UCEC	chr15	101293165	Missense_Mutation	novel	K30N	0.5
UCEC	chr15	101286261	Silent	novel	G164G	0.33
UCEC	chr15	101281670	3'UTR	novel		0.31
UCEC	chr15	101281671	3'UTR	novel		0.31
UCS	chr15	101292037	Silent	novel	R78R	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2068	0.0058042
ESCA	AMP	0.25	0.10665
HNSC	AMP	0.1437	0.094823
LGG	AMP	0.0331	0.19963
LIHC	AMP	0.1216	0.010217
LIHC	DEL	0.1892	0.056724
LUSC	AMP	0.2715	8.9503e-05
OV	AMP	0.2349	8.2865e-07
PAAD	AMP	0.0761	0.20695
SARC	AMP	0.2802	0.053277
SKCM	AMP	0.2561	9.6912e-06
UCEC	AMP	0.0519	0.17061

Survival Analysis

Cancer	P-value	Q-value
THYM	0.011	Kaplan-Meier Survival Analysis
SARC	0.01	Kaplan-Meier Survival Analysis
MESO	0.023	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.045	Kaplan-Meier Survival Analysis
PRAD	0.026	Kaplan-Meier Survival Analysis
KIRP	0.00022	Kaplan-Meier Survival Analysis
BLCA	0.02	Kaplan-Meier Survival Analysis
KICH	0.029	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LUAD	0.0058	Kaplan-Meier Survival Analysis
OV	0.00022	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000131876 (Gene tree)
Gene ID: 6627
Gene Symbol: SNRPA1
Alias: Lea1|U2A'
Full Name: small nuclear ribonucleoprotein polypeptide A'
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 13,773 bases
Position: chr15:101,281,510-101,295,282
Accession: 11152
RBP type: non-canonical RBP
Summary: (Small Nuclear Ribonucleoprotein Polypeptide A') is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. An important paralog of this gene is LRMDA.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558036	SNRPA1-205	2108	-	-	- (aa)	-	-
ENST00000561187	SNRPA1-215	509	-	-	- (aa)	-	-
ENST00000560987	SNRPA1-214	478	-	-	- (aa)	-	-
ENST00000560307	SNRPA1-209	433	-	-	- (aa)	-	-
ENST00000626000	SNRPA1-216	539	-	ENSP00000486896	154 (aa)	-	H0YKK0
ENST00000560856	SNRPA1-213	588	-	-	- (aa)	-	-
ENST00000540017	SNRPA1-203	506	NR_135507	-	- (aa)	-	-
ENST00000560496	SNRPA1-212	824	-	ENSP00000453309	89 (aa)	-	H0YLR3
ENST00000254193	SNRPA1-201	1055	-	ENSP00000254193	255 (aa)	-	P09661
ENST00000559309	SNRPA1-207	924	-	ENSP00000452836	154 (aa)	-	H0YKK0
ENST00000394082	SNRPA1-202	556	NR_135506	-	- (aa)	-	-
ENST00000560433	SNRPA1-211	2440	-	-	- (aa)	-	-
ENST00000560383	SNRPA1-210	565	-	-	- (aa)	-	-
ENST00000558059	SNRPA1-206	678	-	-	- (aa)	-	-
ENST00000558020	SNRPA1-204	466	-	-	- (aa)	-	-
ENST00000559686	SNRPA1-208	625	-	ENSP00000453521	142 (aa)	-	H0YMA0

Gene Model

Click here to download ENSG00000131876's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000131876	rs56377826	15	101287286	T	Lung cancer	28604730	[1.04-1.11]	1.0730215	EFO_0001071

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131876's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000131876	SNRPA1	99	54.605	WBGene00003390	mog-2	92	49.356	Caenorhabditis_elegans
ENSG00000131876	SNRPA1	100	100.000	ENSMUSG00000030512	Snrpa1	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	9731529.11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28076346.28781166.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	9716128.22365833.25416956.	IPI	Function
GO:0005634	nucleus	28076346.28781166.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9731529.	IDA	Component
GO:0005686	U2 snRNP	21873635.	IBA	Component
GO:0007283	spermatogenesis	27035939.	IGI	Process
GO:0008380	RNA splicing	2928112.	TAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0030532	small nuclear ribonucleoprotein complex	2928112.	TAS	Component
GO:0030620	U2 snRNA binding	21873635.	IBA	Function
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0071005	U2-type precatalytic spliceosome	28781166.	IDA	Component
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.