EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26934648	MiR-652-3p is upregulated in non-small cell lung cancer and promotes proliferation and metastasis by directly targeting Lgl1.	Oncotarget	2016 Mar 29	Yang W	doi: 10.18632/oncotarget.7697.
26341367	Hugl-1 inhibits glioma cell growth in intracranial model.	J Neurooncol	2015 Oct	Liu X	doi: 10.1007/s11060-015-1901-3
26662669	Reduced Expression of Hugl 1 Contributes to the Progression of Lung Squamous Cell Carcinoma.	Tokai J Exp Clin Med	2015 Dec 20	Matsuzaki T	-
17369850	aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia.	Oncogene	2007 Aug 30	Grifoni D	-
15735678	Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.	Oncogene	2005 Apr 28	Schimanski CC	-
18074678	Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer.	Oncol Res	2007	Tsuruga T	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	18230012	Silent	rs145857913	I51I	0.44
BLCA	chr17	18238093	Missense_Mutation	novel	L644Q	0.41
BLCA	chr17	18234322	Missense_Mutation	NA	S255L	0.56
BLCA	chr17	18241983	Missense_Mutation	rs200133079	D956N	0.14
BLCA	chr17	18232564	Silent	rs147342699	F83F	0.34
BRCA	chr17	18241982	Silent	rs753952691	R955R	0.37
BRCA	chr17	18242627	Missense_Mutation	NA	G1039R	0.48
CESC	chr17	18234888	Missense_Mutation	NA	D319N	0.76
CESC	chr17	18238529	Missense_Mutation	rs766240619	R709H	0.38
CESC	chr17	18241946	Silent	novel	T943T	0.17
CESC	chr17	18242772	Missense_Mutation	novel	R1049M	0.08
CESC	chr17	18238573	Missense_Mutation	rs138380942	R724C	0.47
CESC	chr17	18236694	Silent	novel	Q480Q	0.44
COAD	chr17	18238109	Silent	rs369186591	P649P	0.29
COAD	chr17	18236936	Silent	novel	G536G	0.44
COAD	chr17	18242806	Silent	NA	A1060A	0.23
COAD	chr17	18235484	Frame_Shift_Ins	NA	*R436Pfs18**	0.37
COAD	chr17	18230009	Silent	NA	A50A	0.19
COAD	chr17	18241661	Missense_Mutation	NA	R905W	0.34
COAD	chr17	18241497	Missense_Mutation	rs753689203	T850M	0.19
COAD	chr17	18232675	Missense_Mutation	rs775418941	R89C	0.27
COAD	chr17	18241982	Silent	rs753952691	R955R	0.22
COAD	chr17	18240700	Missense_Mutation	rs200044915	V777M	0.28
COAD	chr17	18234913	Missense_Mutation	rs150688696	R327Q	0.24
ESCA	chr17	18235229	Missense_Mutation	rs756557977	V401M	0.16
ESCA	chr17	18230025	Missense_Mutation	novel	G56R	0.66
ESCA	chr17	18234376	Missense_Mutation	rs572067853	T273M	0.71
ESCA	chr17	18244586	3'UTR	novel		0.64
ESCA	chr17	18234672	Missense_Mutation	novel	N292D	0.29
GBM	chr17	18232533	Missense_Mutation	rs369006714	R73Q	0.19
GBM	chr17	18235242	Missense_Mutation	NA	P405R	0.43
GBM	chr17	18236638	Missense_Mutation	novel	A462P	0.38
GBM	chr17	18236638	Missense_Mutation	novel	A462P	0.47
GBM	chr17	18235301	Frame_Shift_Ins	novel	*S425Wfs5**	0.94
HNSC	chr17	18234030	Missense_Mutation	rs757927589	R190H	0.25
HNSC	chr17	18241474	Silent	rs376243078	S842S	0.26
KIRC	chr17	18241566	Missense_Mutation	novel	Y873F	0.41
KIRC	chr17	18241567	Nonsense_Mutation	novel	Y873*	0.4
KIRC	chr17	18238211	Frame_Shift_Ins	novel	*L685Vfs10**	0.32
KIRC	chr17	18241598	Silent	NA	L884L	0.07
KIRC	chr17	18232570	Silent	rs551770657	T85T	0.26
KIRP	chr17	18233905	Missense_Mutation	novel	Q174E	0.88
LGG	chr17	18236880	Nonsense_Mutation	novel	Q518*	0.32
LGG	chr17	18242245	Missense_Mutation	novel	G988R	0.38
LIHC	chr17	18235518	Nonsense_Mutation	novel	R445*	0.42
LUAD	chr17	18238519	Missense_Mutation	novel	V706L	0.16
LUAD	chr17	18234147	Missense_Mutation	novel	C229Y	0.17
LUAD	chr17	18236642	Missense_Mutation	novel	S463L	0.17
LUAD	chr17	18241937	Silent	NA	R940R	0.07
LUAD	chr17	18237719	Missense_Mutation	novel	T617S	0.2
LUAD	chr17	18232525	Silent	NA	G70G	0.23
LUAD	chr17	18234844	Missense_Mutation	NA	H304R	0.14
LUAD	chr17	18235135	Silent	NA	L369L	0.67
LUAD	chr17	18230026	Missense_Mutation	NA	G56V	0.41
LUSC	chr17	18234949	Missense_Mutation	novel	R339L	0.62
LUSC	chr17	18238557	Silent	rs750986612	S718S	0.34
LUSC	chr17	18232690	Missense_Mutation	NA	L94I	0.12
LUSC	chr17	18229950	Missense_Mutation	novel	H31Y	0.31
OV	chr17	18238130	Silent	NA	L656L	0.78
OV	chr17	18232792	Frame_Shift_Del	novel	*D128Wfs28**	0.18
OV	chr17	18232793	Frame_Shift_Ins	novel	*G129Ffs29**	0.18
OV	chr17	18236662	Missense_Mutation	NA	L470F	0.3
OV	chr17	18236702	Missense_Mutation	novel	C483F	0.14
OV	chr17	18235258	Silent	NA	A410A	0.4
PAAD	chr17	18229986	Missense_Mutation	novel	D43N	0.21
PAAD	chr17	18232526	Silent	rs139741665	L71L	0.14
PAAD	chr17	18234901	Missense_Mutation	novel	V323A	0.11
PAAD	chr17	18237752	Missense_Mutation	rs144655159	R628H	0.08
PAAD	chr17	18241540	Silent	novel	T864T	0.2
PAAD	chr17	18241908	Nonsense_Mutation	novel	E931*	0.16
PCPG	chr17	18235146	Missense_Mutation	novel	D373G	0.2
PRAD	chr17	18235098	Frame_Shift_Ins	novel	*Q359Pfs95**	0.42
PRAD	chr17	18234022	Silent	rs374218881	D187D	0.12
PRAD	chr17	18234118	Silent	novel	L219L	0.19
PRAD	chr17	18236661	Silent	rs137941953	P469P	0.52
PRAD	chr17	18238159	Missense_Mutation	rs770208654	R666H	0.26
PRAD	chr17	18241507	Missense_Mutation	novel	E853D	0.3
SKCM	chr17	18240594	Silent	NA	P741P	0.24
SKCM	chr17	18236866	Missense_Mutation	novel	P513L	0.4
SKCM	chr17	18240668	Missense_Mutation	novel	G766D	0.68
SKCM	chr17	18235147	Silent	novel	D373D	0.52
SKCM	chr17	18235148	Silent	novel	L374L	0.49
SKCM	chr17	18240617	Missense_Mutation	rs373022414	S749L	0.54
SKCM	chr17	18234377	Silent	rs760245792	T273T	0.23
SKCM	chr17	18238497	Silent	rs747641004	P698P	0.27
SKCM	chr17	18237674	Missense_Mutation	NA	T602I	0.33
SKCM	chr17	18235233	Missense_Mutation	NA	A402V	0.13
SKCM	chr17	18240657	Silent	NA	A762A	0.46
SKCM	chr17	18237594	Silent	rs779111604	S575S	0.56
SKCM	chr17	18234059	Missense_Mutation	NA	S200A	0.5
SKCM	chr17	18229989	Missense_Mutation	novel	P44S	0.47
SKCM	chr17	18229990	Missense_Mutation	rs141705015	P44L	0.47
SKCM	chr17	18236649	Silent	NA	V465V	0.63
SKCM	chr17	18234987	Missense_Mutation	rs780566991	E352K	0.35
STAD	chr17	18236710	Missense_Mutation	rs1063682	A486T	0.24
STAD	chr17	18240700	Missense_Mutation	rs200044915	V777M	0.36
STAD	chr17	18241952	Silent	NA	P945P	0.25
STAD	chr17	18237669	Silent	NA	A600A	0.27
STAD	chr17	18232496	Missense_Mutation	novel	Y61H	0.17
STAD	chr17	18241613	Missense_Mutation	rs746158258	V889I	0.6
STAD	chr17	18240595	Missense_Mutation	NA	T742A	0.07
STAD	chr17	18236742	Silent	novel	D496D	0.28
STAD	chr17	18235484	Frame_Shift_Ins	NA	*R436Pfs18**	0.23
STAD	chr17	18236862	Missense_Mutation	NA	D512N	0.27
STAD	chr17	18237487	Missense_Mutation	NA	V540I	0.24
STAD	chr17	18234297	Missense_Mutation	novel	R247C	0.29
STAD	chr17	18230014	Missense_Mutation	NA	G52D	0.31
STAD	chr17	18234949	Missense_Mutation	rs761985510	R339H	0.33
STAD	chr17	18238117	Missense_Mutation	rs751735771	R652Q	0.43
STAD	chr17	18234974	Silent	novel	H347H	0.12
THCA	chr17	18241900	Missense_Mutation	novel	S928F	0.21
UCEC	chr17	18233798	Missense_Mutation	rs532188095	R138Q	0.27
UCEC	chr17	18240853	Missense_Mutation	rs769047769	A828T	0.34
UCEC	chr17	18229954	Missense_Mutation	novel	G32D	0.12
UCEC	chr17	18236661	Silent	rs137941953	P469P	0.15
UCEC	chr17	18238192	Missense_Mutation	rs757236980	R677Q	0.39
UCEC	chr17	18242595	Missense_Mutation	novel	D1028G	0.32
UCEC	chr17	18234861	Missense_Mutation	novel	G310S	0.1
UCEC	chr17	18236643	Silent	rs759834279	S463S	0.59
UCEC	chr17	18238144	Missense_Mutation	rs138562673	R661H	0.48
UCEC	chr17	18234108	Missense_Mutation	NA	S216N	0.34
UCEC	chr17	18234680	Missense_Mutation	NA	I294M	0.48
UCEC	chr17	18237761	Missense_Mutation	novel	P631H	0.48
UCEC	chr17	18234376	Missense_Mutation	rs572067853	T273M	0.46
UCEC	chr17	18237606	Silent	novel	G579G	0.13
UCEC	chr17	18238603	Nonsense_Mutation	novel	R734*	0.21
UCEC	chr17	18241499	Missense_Mutation	novel	A851T	0.16
UCEC	chr17	18241952	Silent	rs370182207	P945P	0.29
UCEC	chr17	18241982	Silent	rs753952691	R955R	0.2
UCEC	chr17	18229991	Silent	rs761921235	P44P	0.18
UCEC	chr17	18236661	Silent	rs137941953	P469P	0.38
UCEC	chr17	18242597	Missense_Mutation	rs374758088	V1029I	0.4
UCEC	chr17	18232685	Missense_Mutation	novel	S92F	0.38
UCEC	chr17	18234957	Missense_Mutation	novel	D342N	0.48
UCEC	chr17	18241965	Missense_Mutation	novel	D950Y	0.52
UCEC	chr17	18238574	Missense_Mutation	NA	R724H	0.31
UCEC	chr17	18241986	Missense_Mutation	NA	A957T	0.46
UCEC	chr17	18242165	Splice_Site	novel	X961_splice	0.33
UCEC	chr17	18244723	3'UTR	novel		0.9
UCEC	chr17	18242798	Missense_Mutation	rs146701026	A1058T	0.15
UCEC	chr17	18229999	Missense_Mutation	rs368206803	R47H	0.47
UCEC	chr17	18241994	Silent	novel	Q959Q	0.27
UCEC	chr17	18232786	Missense_Mutation	rs768529419	G126S	0.34
UCEC	chr17	18234030	Missense_Mutation	rs757927589	R190H	0.16
UCEC	chr17	18229985	Silent	rs768908181	F42F	0.5
UCEC	chr17	18234030	Missense_Mutation	rs757927589	R190H	0.27
UCEC	chr17	18238159	Missense_Mutation	rs770208654	R666H	0.32
UCEC	chr17	18242587	Silent	novel	T1025T	0.39
UCEC	chr17	18236907	Missense_Mutation	rs146378867	A527T	0.08
UCEC	chr17	18234298	Missense_Mutation	rs376301967	R247H	0.37
UCEC	chr17	18241515	Missense_Mutation	rs778217024	R856H	0.35
UCEC	chr17	18238574	Missense_Mutation	NA	R724H	0.27
UCEC	chr17	18241685	Missense_Mutation	rs546007050	A913T	0.44
UCEC	chr17	18238144	Missense_Mutation	rs138562673	R661H	0.36
UCEC	chr17	18238069	Missense_Mutation	novel	C636Y	0.37
UCEC	chr17	18244781	3'UTR	novel		0.31
UCEC	chr17	18241704	Missense_Mutation	rs749223309	R919H	0.35
UCEC	chr17	18241693	Silent	rs559781387	C915C	0.28
UCEC	chr17	18232679	Missense_Mutation	novel	L90P	0.4
UCEC	chr17	18241690	Silent	rs142110197	S914S	0.2
UCEC	chr17	18237532	Missense_Mutation	novel	A555T	0.35
UCEC	chr17	18242525	Missense_Mutation	rs755481281	E1005K	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.125	0.18166
ESCA	DEL	0.3913	0.074408
LAML	DEL	0.0681	0.12511
LIHC	DEL	0.4	3.9592e-10
READ	DEL	0.6545	0.077076
SARC	AMP	0.3735	8.4923e-19
THCA	DEL	0.014	0.221
UCEC	DEL	0.2245	0.00043918
UCS	DEL	0.5179	0.19877

Survival Analysis

Cancer	P-value	Q-value
THYM	0.029	Kaplan-Meier Survival Analysis
SARC	0.046	Kaplan-Meier Survival Analysis
MESO	0.016	Kaplan-Meier Survival Analysis
HNSC	0.028	Kaplan-Meier Survival Analysis
SKCM	0.0097	Kaplan-Meier Survival Analysis
PRAD	0.012	Kaplan-Meier Survival Analysis
ESCA	0.0047	Kaplan-Meier Survival Analysis
PAAD	0.0076	Kaplan-Meier Survival Analysis
BLCA	0.019	Kaplan-Meier Survival Analysis
READ	0.023	Kaplan-Meier Survival Analysis
UCEC	0.018	Kaplan-Meier Survival Analysis
LIHC	0.00038	Kaplan-Meier Survival Analysis
THCA	0.027	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000131899 (Gene tree)
Gene ID: 3996
Gene Symbol: LLGL1
Alias: Lgl1|Mgl1|DLG4|LLGL|HUGL|HUGL-1
Full Name: LLGL scribble cell polarity complex component 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 19,289 bases
Position: chr17:18,225,587-18,244,875
Accession: 6628
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000621229	LLGL1-203	3187	-	ENSP00000480006	1056 (aa)	-	A0A087WW77
ENST00000479155	LLGL1-202	6004	-	-	- (aa)	-	-
ENST00000316843	LLGL1-201	4260	XM_011523849	ENSP00000321537	1064 (aa)	XP_011522151	Q15334

Gene Model

Click here to download ENSG00000131899's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04390	Hippo signaling pathway	KEGG
hsa04530	Tight junction	KEGG
hsa05165	Human papillomavirus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000131899	Autistic Disorder	2.5018000E-005	-
ENSG00000131899	Autistic Disorder	2.2690000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131899's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000137	Golgi cis cisterna	-	ISS	Component
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005096	GTPase activator activity	-	ISS	Function
GO:0005198	structural molecule activity	7542763.	TAS	Function
GO:0005515	protein binding	7542763.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	7542763.	IDA	Component
GO:0005856	cytoskeleton	7542763.	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0006887	exocytosis	-	IEA	Process
GO:0006893	Golgi to plasma membrane transport	-	ISS	Process
GO:0007409	axonogenesis	-	ISS	Process
GO:0008593	regulation of Notch signaling pathway	21873635.	IBA	Process
GO:0017137	Rab GTPase binding	21873635.	IBA	Function
GO:0019901	protein kinase binding	7542763.	IDA	Function
GO:0030424	axon	-	ISS	Component
GO:0030864	cortical actin cytoskeleton	21873635.	IBA	Component
GO:0030864	cortical actin cytoskeleton	7542763.	IDA	Component
GO:0030866	cortical actin cytoskeleton organization	21873635.	IBA	Process
GO:0030866	cortical actin cytoskeleton organization	7542763.	IDA	Process
GO:0031901	early endosome membrane	-	ISS	Component
GO:0032588	trans-Golgi network membrane	-	ISS	Component
GO:0032878	regulation of establishment or maintenance of cell polarity	21873635.	IBA	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0051294	establishment of spindle orientation	21873635.	IBA	Process
GO:0065003	protein-containing complex assembly	7542763.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.