EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26934648MiR-652-3p is upregulated in non-small cell lung cancer and promotes proliferation and metastasis by directly targeting Lgl1.Oncotarget2016 Mar 29Yang Wdoi: 10.18632/oncotarget.7697.
26341367Hugl-1 inhibits glioma cell growth in intracranial model.J Neurooncol2015 OctLiu Xdoi: 10.1007/s11060-015-1901-3
26662669Reduced Expression of Hugl 1 Contributes to the Progression of Lung Squamous Cell Carcinoma.Tokai J Exp Clin Med2015 Dec 20Matsuzaki T-
17369850aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia.Oncogene2007 Aug 30Grifoni D-
15735678Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.Oncogene2005 Apr 28Schimanski CC-
18074678Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer.Oncol Res2007Tsuruga T-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1718230012Silentrs145857913I51I0.44
BLCAchr1718238093Missense_MutationnovelL644Q0.41
BLCAchr1718234322Missense_MutationNAS255L0.56
BLCAchr1718241983Missense_Mutationrs200133079D956N0.14
BLCAchr1718232564Silentrs147342699F83F0.34
BRCAchr1718241982Silentrs753952691R955R0.37
BRCAchr1718242627Missense_MutationNAG1039R0.48
CESCchr1718234888Missense_MutationNAD319N0.76
CESCchr1718238529Missense_Mutationrs766240619R709H0.38
CESCchr1718241946SilentnovelT943T0.17
CESCchr1718242772Missense_MutationnovelR1049M0.08
CESCchr1718238573Missense_Mutationrs138380942R724C0.47
CESCchr1718236694SilentnovelQ480Q0.44
COADchr1718238109Silentrs369186591P649P0.29
COADchr1718236936SilentnovelG536G0.44
COADchr1718242806SilentNAA1060A0.23
COADchr1718235484Frame_Shift_InsNAR436Pfs*180.37
COADchr1718230009SilentNAA50A0.19
COADchr1718241661Missense_MutationNAR905W0.34
COADchr1718241497Missense_Mutationrs753689203T850M0.19
COADchr1718232675Missense_Mutationrs775418941R89C0.27
COADchr1718241982Silentrs753952691R955R0.22
COADchr1718240700Missense_Mutationrs200044915V777M0.28
COADchr1718234913Missense_Mutationrs150688696R327Q0.24
ESCAchr1718235229Missense_Mutationrs756557977V401M0.16
ESCAchr1718230025Missense_MutationnovelG56R0.66
ESCAchr1718234376Missense_Mutationrs572067853T273M0.71
ESCAchr17182445863'UTRnovel0.64
ESCAchr1718234672Missense_MutationnovelN292D0.29
GBMchr1718232533Missense_Mutationrs369006714R73Q0.19
GBMchr1718235242Missense_MutationNAP405R0.43
GBMchr1718236638Missense_MutationnovelA462P0.38
GBMchr1718236638Missense_MutationnovelA462P0.47
GBMchr1718235301Frame_Shift_InsnovelS425Wfs*50.94
HNSCchr1718234030Missense_Mutationrs757927589R190H0.25
HNSCchr1718241474Silentrs376243078S842S0.26
KIRCchr1718241566Missense_MutationnovelY873F0.41
KIRCchr1718241567Nonsense_MutationnovelY873*0.4
KIRCchr1718238211Frame_Shift_InsnovelL685Vfs*100.32
KIRCchr1718241598SilentNAL884L0.07
KIRCchr1718232570Silentrs551770657T85T0.26
KIRPchr1718233905Missense_MutationnovelQ174E0.88
LGGchr1718236880Nonsense_MutationnovelQ518*0.32
LGGchr1718242245Missense_MutationnovelG988R0.38
LIHCchr1718235518Nonsense_MutationnovelR445*0.42
LUADchr1718238519Missense_MutationnovelV706L0.16
LUADchr1718234147Missense_MutationnovelC229Y0.17
LUADchr1718236642Missense_MutationnovelS463L0.17
LUADchr1718241937SilentNAR940R0.07
LUADchr1718237719Missense_MutationnovelT617S0.2
LUADchr1718232525SilentNAG70G0.23
LUADchr1718234844Missense_MutationNAH304R0.14
LUADchr1718235135SilentNAL369L0.67
LUADchr1718230026Missense_MutationNAG56V0.41
LUSCchr1718234949Missense_MutationnovelR339L0.62
LUSCchr1718238557Silentrs750986612S718S0.34
LUSCchr1718232690Missense_MutationNAL94I0.12
LUSCchr1718229950Missense_MutationnovelH31Y0.31
OVchr1718238130SilentNAL656L0.78
OVchr1718232792Frame_Shift_DelnovelD128Wfs*280.18
OVchr1718232793Frame_Shift_InsnovelG129Ffs*290.18
OVchr1718236662Missense_MutationNAL470F0.3
OVchr1718236702Missense_MutationnovelC483F0.14
OVchr1718235258SilentNAA410A0.4
PAADchr1718229986Missense_MutationnovelD43N0.21
PAADchr1718232526Silentrs139741665L71L0.14
PAADchr1718234901Missense_MutationnovelV323A0.11
PAADchr1718237752Missense_Mutationrs144655159R628H0.08
PAADchr1718241540SilentnovelT864T0.2
PAADchr1718241908Nonsense_MutationnovelE931*0.16
PCPGchr1718235146Missense_MutationnovelD373G0.2
PRADchr1718235098Frame_Shift_InsnovelQ359Pfs*950.42
PRADchr1718234022Silentrs374218881D187D0.12
PRADchr1718234118SilentnovelL219L0.19
PRADchr1718236661Silentrs137941953P469P0.52
PRADchr1718238159Missense_Mutationrs770208654R666H0.26
PRADchr1718241507Missense_MutationnovelE853D0.3
SKCMchr1718240594SilentNAP741P0.24
SKCMchr1718236866Missense_MutationnovelP513L0.4
SKCMchr1718240668Missense_MutationnovelG766D0.68
SKCMchr1718235147SilentnovelD373D0.52
SKCMchr1718235148SilentnovelL374L0.49
SKCMchr1718240617Missense_Mutationrs373022414S749L0.54
SKCMchr1718234377Silentrs760245792T273T0.23
SKCMchr1718238497Silentrs747641004P698P0.27
SKCMchr1718237674Missense_MutationNAT602I0.33
SKCMchr1718235233Missense_MutationNAA402V0.13
SKCMchr1718240657SilentNAA762A0.46
SKCMchr1718237594Silentrs779111604S575S0.56
SKCMchr1718234059Missense_MutationNAS200A0.5
SKCMchr1718229989Missense_MutationnovelP44S0.47
SKCMchr1718229990Missense_Mutationrs141705015P44L0.47
SKCMchr1718236649SilentNAV465V0.63
SKCMchr1718234987Missense_Mutationrs780566991E352K0.35
STADchr1718236710Missense_Mutationrs1063682A486T0.24
STADchr1718240700Missense_Mutationrs200044915V777M0.36
STADchr1718241952SilentNAP945P0.25
STADchr1718237669SilentNAA600A0.27
STADchr1718232496Missense_MutationnovelY61H0.17
STADchr1718241613Missense_Mutationrs746158258V889I0.6
STADchr1718240595Missense_MutationNAT742A0.07
STADchr1718236742SilentnovelD496D0.28
STADchr1718235484Frame_Shift_InsNAR436Pfs*180.23
STADchr1718236862Missense_MutationNAD512N0.27
STADchr1718237487Missense_MutationNAV540I0.24
STADchr1718234297Missense_MutationnovelR247C0.29
STADchr1718230014Missense_MutationNAG52D0.31
STADchr1718234949Missense_Mutationrs761985510R339H0.33
STADchr1718238117Missense_Mutationrs751735771R652Q0.43
STADchr1718234974SilentnovelH347H0.12
THCAchr1718241900Missense_MutationnovelS928F0.21
UCECchr1718233798Missense_Mutationrs532188095R138Q0.27
UCECchr1718240853Missense_Mutationrs769047769A828T0.34
UCECchr1718229954Missense_MutationnovelG32D0.12
UCECchr1718236661Silentrs137941953P469P0.15
UCECchr1718238192Missense_Mutationrs757236980R677Q0.39
UCECchr1718242595Missense_MutationnovelD1028G0.32
UCECchr1718234861Missense_MutationnovelG310S0.1
UCECchr1718236643Silentrs759834279S463S0.59
UCECchr1718238144Missense_Mutationrs138562673R661H0.48
UCECchr1718234108Missense_MutationNAS216N0.34
UCECchr1718234680Missense_MutationNAI294M0.48
UCECchr1718237761Missense_MutationnovelP631H0.48
UCECchr1718234376Missense_Mutationrs572067853T273M0.46
UCECchr1718237606SilentnovelG579G0.13
UCECchr1718238603Nonsense_MutationnovelR734*0.21
UCECchr1718241499Missense_MutationnovelA851T0.16
UCECchr1718241952Silentrs370182207P945P0.29
UCECchr1718241982Silentrs753952691R955R0.2
UCECchr1718229991Silentrs761921235P44P0.18
UCECchr1718236661Silentrs137941953P469P0.38
UCECchr1718242597Missense_Mutationrs374758088V1029I0.4
UCECchr1718232685Missense_MutationnovelS92F0.38
UCECchr1718234957Missense_MutationnovelD342N0.48
UCECchr1718241965Missense_MutationnovelD950Y0.52
UCECchr1718238574Missense_MutationNAR724H0.31
UCECchr1718241986Missense_MutationNAA957T0.46
UCECchr1718242165Splice_SitenovelX961_splice0.33
UCECchr17182447233'UTRnovel0.9
UCECchr1718242798Missense_Mutationrs146701026A1058T0.15
UCECchr1718229999Missense_Mutationrs368206803R47H0.47
UCECchr1718241994SilentnovelQ959Q0.27
UCECchr1718232786Missense_Mutationrs768529419G126S0.34
UCECchr1718234030Missense_Mutationrs757927589R190H0.16
UCECchr1718229985Silentrs768908181F42F0.5
UCECchr1718234030Missense_Mutationrs757927589R190H0.27
UCECchr1718238159Missense_Mutationrs770208654R666H0.32
UCECchr1718242587SilentnovelT1025T0.39
UCECchr1718236907Missense_Mutationrs146378867A527T0.08
UCECchr1718234298Missense_Mutationrs376301967R247H0.37
UCECchr1718241515Missense_Mutationrs778217024R856H0.35
UCECchr1718238574Missense_MutationNAR724H0.27
UCECchr1718241685Missense_Mutationrs546007050A913T0.44
UCECchr1718238144Missense_Mutationrs138562673R661H0.36
UCECchr1718238069Missense_MutationnovelC636Y0.37
UCECchr17182447813'UTRnovel0.31
UCECchr1718241704Missense_Mutationrs749223309R919H0.35
UCECchr1718241693Silentrs559781387C915C0.28
UCECchr1718232679Missense_MutationnovelL90P0.4
UCECchr1718241690Silentrs142110197S914S0.2
UCECchr1718237532Missense_MutationnovelA555T0.35
UCECchr1718242525Missense_Mutationrs755481281E1005K0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.1250.18166
ESCADEL0.39130.074408
LAMLDEL0.06810.12511
LIHCDEL0.43.9592e-10
READDEL0.65450.077076
SARCAMP0.37358.4923e-19
THCADEL0.0140.221
UCECDEL0.22450.00043918
UCSDEL0.51790.19877

Survival Analysis
CancerP-value Q-value
THYM0.029

Kaplan-Meier Survival Analysis

SARC0.046

Kaplan-Meier Survival Analysis

MESO0.016

Kaplan-Meier Survival Analysis

HNSC0.028

Kaplan-Meier Survival Analysis

SKCM0.0097

Kaplan-Meier Survival Analysis

PRAD0.012

Kaplan-Meier Survival Analysis

ESCA0.0047

Kaplan-Meier Survival Analysis

PAAD0.0076

Kaplan-Meier Survival Analysis

BLCA0.019

Kaplan-Meier Survival Analysis

READ0.023

Kaplan-Meier Survival Analysis

UCEC0.018

Kaplan-Meier Survival Analysis

LIHC0.00038

Kaplan-Meier Survival Analysis

THCA0.027

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000131899 (Gene tree)
Gene ID
3996
Gene Symbol
LLGL1
Alias
Lgl1|Mgl1|DLG4|LLGL|HUGL|HUGL-1
Full Name
LLGL scribble cell polarity complex component 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
19,289 bases
Position
chr17:18,225,587-18,244,875
Accession
6628
RBP type
non-canonical RBP
Summary
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000621229LLGL1-2033187-ENSP000004800061056 (aa)-A0A087WW77
ENST00000479155LLGL1-2026004--- (aa)--
ENST00000316843LLGL1-2014260XM_011523849ENSP000003215371064 (aa)XP_011522151Q15334
Gene Model
Click here to download ENSG00000131899's gene model file
Pathways
Pathway IDPathway NameSource
hsa04390Hippo signaling pathwayKEGG
hsa04530Tight junctionKEGG
hsa05165Human papillomavirus infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000131899Autistic Disorder2.5018000E-005-
ENSG00000131899Autistic Disorder2.2690000E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131899's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000137Golgi cis cisterna-ISSComponent
GO:0005096GTPase activator activity21873635.IBAFunction
GO:0005096GTPase activator activity-ISSFunction
GO:0005198structural molecule activity7542763.TASFunction
GO:0005515protein binding7542763.IPIFunction
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm7542763.IDAComponent
GO:0005856cytoskeleton7542763.TASComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0006887exocytosis-IEAProcess
GO:0006893Golgi to plasma membrane transport-ISSProcess
GO:0007409axonogenesis-ISSProcess
GO:0008593regulation of Notch signaling pathway21873635.IBAProcess
GO:0017137Rab GTPase binding21873635.IBAFunction
GO:0019901protein kinase binding7542763.IDAFunction
GO:0030424axon-ISSComponent
GO:0030864cortical actin cytoskeleton21873635.IBAComponent
GO:0030864cortical actin cytoskeleton7542763.IDAComponent
GO:0030866cortical actin cytoskeleton organization21873635.IBAProcess
GO:0030866cortical actin cytoskeleton organization7542763.IDAProcess
GO:0031901early endosome membrane-ISSComponent
GO:0032588trans-Golgi network membrane-ISSComponent
GO:0032878regulation of establishment or maintenance of cell polarity21873635.IBAProcess
GO:0043547positive regulation of GTPase activity-IEAProcess
GO:0051294establishment of spindle orientation21873635.IBAProcess
GO:0065003protein-containing complex assembly7542763.IDAProcess
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