EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
16518858Tumor-associated antigen 90K/Mac-2-binding protein: possible role in colon cancer.J Cell Biochem2006 Aug 1Ulmer TA-
23090139Clinicopathological significance of decreased galectin-3 expression and the long-term prognosis in patients with breast cancer.Surg Today2013 AugYamaki Sdoi: 10.1007/s00595-012-0378-3
25980453New biomarkers for early detection of cardiotoxicity after treatment with docetaxel, doxorubicin and cyclophosphamide.Biomarkers2015 Marvan Boxtel Wdoi: 10.3109/1354750X.2015.1040839
21234707Inmunohistochemical profile of solid cell nest of thyroid gland.Endocr Pathol2011 MarR??os Moreno MJdoi: 10.1007/s12022-010-9145-4.
22546645Galectins testing: new promises for the diagnosis and risk stratification of chronic diseases?Clin Biochem2012 JulGruson Ddoi: 10.1016/j.clinbiochem.2012.04.009
18089806Galectin-3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancers.Cancer Res2007 Dec 15Nangia-Makker P-
26894286LGALS3 and AXIN1 gene variants playing role in the Wnt/ β-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer.Bosn J Basic Med Sci2016 Feb 4Korkmaz Gdoi: 10.17305/bjbms.2016.721.
30535445Hypoxiainduced galectin3 enhances RhoA function to activate the motility of tumor cells in nonsmall cell lung cancer.Oncol Rep2019 FebKataoka Ydoi: 10.3892/or.2018.6915
25658354Caveolin-1, galectin-3 and lipid raft domains in cancer cell signalling.Essays Biochem2015Shankar Jdoi: 10.1042/bse0570189.
18757439Tumor-associated galectin-3 modulates the function of tumor-reactive T cells.Cancer Res2008 Sep 1Peng Wdoi: 10.1158/0008-5472.CAN-08-1245.
25315772Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack.J Biol Chem2014 Nov 28Wang Wdoi: 10.1074/jbc.M114.603464
19020999RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors.Endocrine2009 FebZhang HYdoi: 10.1007/s12020-008-9129-z
15326483Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3.Oncogene2004 Sep 30Califice S-
20450430CXC chemokine receptor 4 immunodetection in the follicular variant of papillary thyroid carcinoma: comparison to galectin-3 and hector battifora mesothelial cell-1.Thyroid2010 MayTorregrossa Ldoi: 10.1089/thy.2009.0282.
22892876Galectin-3 expression in prostate cancer and benign prostate tissues: correlation with biochemical recurrence.World J Urol2013 AprKnapp JSdoi: 10.1007/s00345-012-0925-y
24520024An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor.Cancer Discov2014 MarMurugaesu Ndoi: 10.1158/2159-8290.CD-13-0287
22465244The effect of galectin-3 genetic variants on the susceptibility and prognosis of gliomas in a Chinese population.Neurosci Lett2012 Jun 14Chen HJdoi: 10.1016/j.neulet.2012.02.065
17221114[Polymorphism on codon 98 of the galectin-3 gene is not associated to benign and malignant thyroid tumors].Arq Bras Endocrinol Metabol2006 DecMartins L-
16996782Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands.Oral Oncol2007 JulFerrazzo KL-
25177969Reduction of galectin-3 expression reduces pituitary tumor cell progression.Genet Mol Res2014 Aug 29Huang CXdoi: 10.4238/2014.August.29.11.
25369297Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survival.PLoS One2014 Nov 4Ikemori RYdoi: 10.1371/journal.pone.0111592
25138305Galectin-3 in angiogenesis and metastasis.Glycobiology2014 OctFunasaka Tdoi: 10.1093/glycob/cwu086
22152245[Serum and tissue expressions of galectin-3 in hepatocellular carcinoma and the clinical significances].Zhonghua Gan Zang Bing Za Zhi2011 JulFang QQdoi: 10.3760/cma.j.issn.1007-3418.2011.07.014.
18438928Runx2 is expressed in human glioma cells and mediates the expression of galectin-3.J Neurosci Res2008 Aug 15Vladimirova Vdoi: 10.1002/jnr.21686.
18581271Galectin-3 expression in tumor progression and metastasis of papillary thyroid carcinoma.Endocr Pathol2008 SummerT??rkz HKdoi: 10.1007/s12022-008-9033-3.
16651632Galectin-3 expression correlates with apoptosis of tumor-associated lymphocytes in human melanoma biopsies.Am J Pathol2006 MayZubieta MR-
23953881Suppression of SERPINA1-albumin complex formation by galectin-3 overexpression leads to paracrine growth promotion of chronic myelogenous leukemia cells.Leuk Res2014 JanNakayama Rdoi: 10.1016/j.leukres.2013.07.026
21397408Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue.Pathol Res Pract2011 Apr 15Alves PMdoi: 10.1016/j.prp.2011.02.004
16244583Galectin-3 and proliferating cell nuclear antigen (PCNA) expression in papillary thyroid carcinoma.Exp Oncol2005 SepCvejic D-
20855213Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3.J Clin Neurosci2011 JanShen Jdoi: 10.1016/j.jocn.2010.03.066
18676377Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis.J Biol Chem2008 Aug 8Zhuo Ydoi: 10.1074/jbc.M8000015200.
18951731Immunohistochemical galectin-3 expression in non-melanoma skin cancers.Pathol Res Pract2009Kapucuoglu Ndoi: 10.1016/j.prp.2008.09.001
27959409Galectin-3 inhibition ameliorates hypoxia-induced pulmonary artery hypertension.Mol Med Rep2017 JanHao Mdoi: 10.3892/mmr.2016.6020
28104787Binding characteristics of galectin-3 fusion proteins.Glycobiology2017 May 1Bcker Sdoi: 10.1093/glycob/cwx007.
28215640Immunohistochemical expression of galectin-3 is significantly associated with grade, stage and differentiation of endometrial carcinomas.Pathol Res Pract2017 AprAl-Maghrabi Jdoi: 10.1016/j.prp.2017.01.012
29277781Expression and Distribution of Galectin-3 in Chromophobe and Papillary Carcinomas.Anticancer Res2018 JanCioca A-
27835877O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer.Oncotarget2016 Dec 13Santos SNdoi: 10.18632/oncotarget.13192.
28533486Galectin-3 acts as an angiogenic switch to induce tumor angiogenesis via Jagged-1/Notch activation.Oncotarget2017 Jul 25Dos Santos SNdoi: 10.18632/oncotarget.17718.
29389859Role of Galectins in Tumors and in Clinical Immunotherapy.Int J Mol Sci2018 Feb 1Chou FCdoi: 10.3390/ijms19020430.
29580041Galectin-3 Serum Levels Could Help Clinicians Screen for Salivary Gland Tumor PatientsAsian Pac J Cancer Prev2018 Mar 27Andisheh-Tadbir A-
27012551Galectin-3 regulates metastatic capabilities and chemotherapy sensitivity in epithelial ovarian carcinoma via NF-??B pathway.Tumour Biol2016 AugLu Hdoi: 10.1007/s13277-016-5004-3
17090543Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.J Biol Chem2007 Jan 5Yu LG-
27035870Knockdown of LI-cadherin alters expression of matrix metalloproteinase-2 and -9 and galectin-3.Mol Med Rep2016 MayYu Qdoi: 10.3892/mmr.2016.5069
25034653Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patients.Clin Exp Med2015 AugLeal MFdoi: 10.1007/s10238-014-0299-0
18418527Expression of Galectin-3 and Galectin-7 in thyroid malignancy as potential diagnostic indicators.Singapore Med J2008 AprThan TH-
18319555Serum level of galectin-3 in human bladder cancer.J Med Invest2008 FebSakaki M-
19690136Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface.Cancer Res2009 Sep 1Zhao Qdoi: 10.1158/0008-5472.CAN-09-1096
15362030A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancer.Gastroenterology2004 SepBresalier RS-
22039439Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers.PLoS One2011Idikio HAdoi: 10.1371/journal.pone.0026150
30626779Galectin-3 regulates chemotherapy sensitivity in epithelial ovarian carcinoma via regulating mitochondrial function.J Toxicol Sci2019Wang Ddoi: 10.2131/jts.44.47.
23625538Galectin-3: a possible complementary marker to the PSA blood test.Oncotarget2013 AprBalan V-
23235344Diagnostic and prognostic role of HBME-1, galectin-3, and β-catenin in poorly differentiated and anaplastic thyroid carcinomas.Appl Immunohistochem Mol Morphol2013 MayRossi EDdoi: 10.1097/PAI.0b013e3182688d0f.
23907467The significance of galectin-3 as a new basal cell marker in prostate cancer.Cell Death Dis2013 Aug 1Wang Ydoi: 10.1038/cddis.2013.277.
20363921Diagnostic utility of galectin-3 in thyroid cancer.Am J Pathol2010 MayChiu CGdoi: 10.2353/ajpath.2010.090353
18008332Involvement of decreased Galectin-3 expression in the pathogenesis and progression of prostate cancer.Prostate2008 Jan 1Merseburger AS-
22024187Galectin-3 and cyclin D1 expression in non-small cell lung cancer.J Exp Clin Cancer Res2011 Oct 24Kosacka Mdoi: 10.1186/1756-9966-30-101.
17534895Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.Int J Cancer2007 Sep 15Shi Y-
26429330Role of galectin-3 in the pathogenesis of bladder transitional cell carcinoma.Hum Immunol2015 OctZeinali Mdoi: 10.1016/j.humimm.2015.09.036
18657294Thyroid peroxidase and galectin-3 immunostaining in differentiated thyroid carcinoma with clinicopathologic correlation.Hum Pathol2008 NovSavin Sdoi: 10.1016/j.humpath.2008.04.006
20014549Diagnostic utility of MOC-31, HBME-1 and MOC-31 mRNA in distinguishing between carcinoma cells and reactive mesothelial cells in pleural effusions.Acta Cytol2009 Nov-DecSun Y-
19286570Regulation of prostate cancer progression by galectin-3.Am J Pathol2009 AprWang Ydoi: 10.2353/ajpath.2009.080816
25942420Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration.PLoS One2015 May 5Meng Fdoi: 10.1371/journal.pone.0126056
19723119Suppression of galectin-3 expression enhances apoptosis and chemosensitivity in liver fluke-associated cholangiocarcinoma.Cancer Sci2009 NovWongkham Sdoi: 10.1111/j.1349-7006.2009.01304.x
18395901Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3.World J Gastroenterol2008 Apr 7Jiang HB-
22497866Up-regulation of galectin-3 and Sambucus nigra agglutinin binding site is associated with invasion, metastasis and poor-progression of the gallbladder adenocarcinoma.Hepatogastroenterology2012 OctYang LP-
12673672Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancer.Int J Cancer2003 Jun 10Mollenhauer J-
24281352Galectin-3 coats the membrane of breast cells and makes a signature of tumours.Mol Biosyst2014 FebSimone Gdoi: 10.1039/c3mb70359b.
21331750Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells.Clin Exp Metastasis2011 AprKobayashi Tdoi: 10.1007/s10585-011-9376-x
16369807Decreased galectin-3 expression during the progression of cervical neoplasia.J Cancer Res Clin Oncol2006 AprLee JW-
22900040Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling.PLoS One2012Song Sdoi: 10.1371/journal.pone.0042699
27059733Galectin-3 induces ovarian cancer cell survival and chemoresistance via TLR4 signaling activation.Tumour Biol2016 SepCai G-
26224120Galectin-Binding O-Glycosylations as Regulators of Malignancy.Cancer Res2015 Aug 15Dimitroff CJdoi: 10.1158/0008-5472.CAN-15-0834
23479624Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis.Proc Natl Acad Sci U S A2013 Mar 26Guha Pdoi: 10.1073/pnas.1202653110
21966428Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1).PLoS One2011Kim SJdoi: 10.1371/journal.pone.0025103
25765552Serum galectin-3 as a potential marker for gastric cancer.Med Sci Monit2015 Mar 13Cheng Ddoi: 10.12659/MSM.892386.
26708131Co-expression of galectin-3 and CRIP-1 in endometrial cancer: prognostic value and patient survival.Med Oncol2016 JanLambropoulou Mdoi: 10.1007/s12032-015-0723-7
22513979Coordinated expression of galectin-3 and caveolin-1 in thyroid cancer.J Pathol2012 SepShankar Jdoi: 10.1002/path.4041
17481580Differential expression of galectins in normal, benign and malignant prostate epithelial cells: silencing of galectin-3 expression in prostate cancer by its promoter methylation.Biochem Biophys Res Commun2007 Jun 22Ahmed H-
26289852Identification of a panel of complex autoantigens (LGALS3, PHB2, MUC1, and GK2) in combination with CA15-3 for the diagnosis of early-stage breast cancer.Tumour Biol2016 JanZuo Xdoi: 10.1007/s13277-015-3932-y
20401558Galectin-3 expression is associated with bladder cancer progression and clinical outcome.Tumour Biol2010 AugCanesin Gdoi: 10.1007/s13277-010-0033-9
19843071Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents.Cancer Sci2010 JanCheong TCdoi: 10.1111/j.1349-7006.2009.01364.x
19781269[The expression of galectin-3 and osteopontin in occult metastasis of non-small cell lung cancer].Zhonghua Wai Ke Za Zhi2009 Jul 15Liang Y-
19818782Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression.Gastroenterology2010 MarKim SJdoi: 10.1053/j.gastro.2009.09.061
23117840Simultaneous determination of serum galectin-3 and -4 levels detects metastases in colorectal cancer patients.Cell Oncol (Dordr)2013 FebBarrow Hdoi: 10.1007/s13402-012-0109-1
25254965Galectin-3 as a marker and potential therapeutic target in breast cancer.PLoS One2014 Sep 25Zhang Hdoi: 10.1371/journal.pone.0103482
21446041A galectin-3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells.Cancer2011 Oct 1Mazurek Ndoi: 10.1002/cncr.26078
25373317Effect of galectin-3 on the behavior of Eca109 human esophageal cancer cells.Mol Med Rep2015 FebLiang Ndoi: 10.3892/mmr.2014.2873
20622331[Expression of galectin-3 and Sambucus nigra agglutinin and its clinicopathological significance in benign and malignant lesions of breast].Zhong Nan Da Xue Xue Bao Yi Xue Ban2010 JunChen Gdoi: 10.3969/j.issn.1672-7347.2010.06.008.
21750908Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of β-catenin in gastric cancer.Clin Exp Metastasis2011 DecKim SJdoi: 10.1007/s10585-011-9406-8
15579437Alterations in galectin-3 expression and distribution correlate with breast cancer progression: functional analysis of galectin-3 in breast epithelial-endothelial interactions.Am J Pathol2004 DecShekhar MP-
20204403Serum Cyfra 21.1 and galectin-3 protein levels in relation to immunohistochemical cytokeratin 19 and galectin-3 expression in patients with thyroid tumors.J Cancer Res Clin Oncol2010 DecIi Tdoi: 10.1007/s00432-010-0838-3
18024302[Association of galectin-3 and E-cadherin expressions with lymph node metastasis of colon cancer].Nan Fang Yi Ke Da Xue Xue Bao2007 NovWu ZH-
23401226Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium.Clin Cancer Res2013 Apr 1Chen Cdoi: 10.1158/1078-0432.CCR-12-2940
21258405Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells.Oncogene2011 Jun 2Merlin Jdoi: 10.1038/onc.2010.631
19074869Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study.Cancer Res2008 Dec 15Balan Vdoi: 10.1158/0008-5472.CAN-08-3224.
19053747Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.J Med Chem2008 Dec 25Delaine Tdoi: 10.1021/jm801077j.
26447186Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer.Glycobiology2016 FebKuo HYdoi: 10.1093/glycob/cwv088
17544840The role of galectin-3 in cancer drug resistance.Drug Resist Updat2007 JunFukumori T-
16285957Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation.Gastroenterology2005 NovSong S-
20565834Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis.Mol Cancer2010 Jun 18Zhao Qdoi: 10.1186/1476-4598-9-154.
28011482Galectin-3 Is Implicated in Tumor Progression and Resistance to Anti-androgen Drug Through Regulation of Androgen Receptor Signaling in Prostate Cancer.Anticancer Res2017 JanDondoo TO-
23103626Galectin-3 gene silencing inhibits migration and invasion of human tongue cancer cells in vitro via downregulating β-catenin.Acta Pharmacol Sin2013 JanZhang Ddoi: 10.1038/aps.2012.150
24650367Vascular endothelial growth factor C enhances cervical cancer cell invasiveness via upregulation of galectin-3 protein.Gynecol Endocrinol2014 JunLiu Jdoi: 10.3109/09513590.2014.898054
23015305Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras-Raf-Erk1/2 pathway.J Gastroenterol2013 MarWu KLdoi: 10.1007/s00535-012-0663-3
26264495Galectin 3 as a guardian of the tumor microenvironment.Biochim Biophys Acta2016 MarRuvolo PPdoi: 10.1016/j.bbamcr.2015.08.008
15843888On the role of galectin-3 in cancer apoptosis.Apoptosis2005 MarNakahara S-
18584353Identification of galectin-3 and mucin-type O-glycans in breast cancer and its metastasis to brain.Cancer Invest2008 JulMayoral MAdoi: 10.1080/07357900701837051.
18542048Expression of galectin-3 in the tumor immune response in colon cancer.Lab Invest2008 AugDumont Pdoi: 10.1038/labinvest.2008.54
20635166Immunoexpression of galectin-3 in colorectal cancer and its relationship with survival.J Gastrointest Cancer2011 DecZaia Povegliano Ldoi: 10.1007/s12029-010-9189-1.
23160381Galectin-3 regulates p21 stability in human prostate cancer cells.Oncogene2013 Oct 17Wang Ydoi: 10.1038/onc.2012.528
21516492Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention.Eur J Nutr2012 FebLi Ydoi: 10.1007/s00394-011-0194-3
21396839Apoptosis gene polymorphisms and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy.Urol Oncol2013 JanMeyer Adoi: 10.1016/j.urolonc.2010.09.011
19124005Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells.Biochem Biophys Res Commun2009 Feb 6Lin CIdoi: 10.1016/j.bbrc.2008.12.153
25788032Galectin-3 knockdown increases gefitinib sensitivity to the inhibition of EGFR endocytosis in gefitinib-insensitive esophageal squamous cancer cells.Med Oncol2015 AprCui Gdoi: 10.1007/s12032-015-0570-6
18942707High expression of 90K (Mac-2 BP) is associated with poor survival in node-negative breast cancer patients not receiving adjuvant systemic therapies.Int J Cancer2009 Jan 15Tinari Ndoi: 10.1002/ijc.23970.
27687248Low expression of galectin-3 is associated with poor survival in node-positive breast cancers and mesenchymal phenotype in breast cancer stem cells.Breast Cancer Res2016 Sep 29Ilmer Mdoi: 10.1186/s13058-016-0757-6.
27617577RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways.Oncogene2017 Mar 2Zhang Ldoi: 10.1038/onc.2016.306
28146425Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression.Oncotarget2017 Feb 28Lu Wdoi: 10.18632/oncotarget.14839.
28870921Significance of Circulating Galectin-3 in Patients with Pancreatobiliary Cancer.Anticancer Res2017 SepShimura T-
26934444An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells.Oncotarget2016 Mar 22Tseng PCdoi: 10.18632/oncotarget.7750.
27626163Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain.Oncotarget2016 Oct 18Kang HGdoi: 10.18632/oncotarget.11920.
27741512Positive associations between galectin-3 and PSA levels in prostate cancer patients: a prospective clinical study-I.Oncotarget2016 Dec 13Nakajima Kdoi: 10.18632/oncotarget.12619.
28594391Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients.Int J Mol Sci2017 Jun 8Schulz Hdoi: 10.3390/ijms18061230.
28627758Spectral library-based glycopeptide analysis-detection of circulating galectin-3 binding protein in pancreatic cancer.Proteomics Clin Appl2017 SepNigjeh ENdoi: 10.1002/prca.201700064
28430337Circulating neuregulin-1 and galectin-3 can be prognostic markers in breast cancer.Int J Biol Markers2017 Jul 24De Iuliis Fdoi: 10.5301/ijbm.5000262.
28731466Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.Cell Death Differ2017 NovPiyush Tdoi: 10.1038/cdd.2017.119
29393868Galectin-3: The Impact on the Clinical Management of Patients with Thyroid Nodules and Future Perspectives.Int J Mol Sci2018 Feb 2Bartolazzi Adoi: 10.3390/ijms19020445.
28848207Correlations of Galectin-3 Gene Polymorphisms with Risk and Prognosis of Cervical Cancer in Chinese Populations: A Case-Control Study.Oncol Res Treat2017Fang SQdoi: 10.1159/000475502
30249872The clinical importance of serum galectin-3 levels in breast cancer patients with and without metastasis.J Cancer Res Ther2018 SepTopcu TOdoi: 10.4103/0973-1482.176425.
30115022Galectin 3 expression in regional lymph nodes and lymph node metastases of oral squamous cell carcinomas.BMC Cancer2018 Aug 16Wehrhan Fdoi: 10.1186/s12885-018-4726-6.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1455145188Missense_Mutationrs778604374R224W0.26
BLCAchr1455140317Missense_Mutationrs755491373R129C0.38
BRCAchr1455145167Missense_MutationNAH217Y0.12
CESCchr1455142746Missense_MutationNAF198L0.29
COADchr1455138219Missense_MutationNAG65R0.24
COADchr1455140318Missense_Mutationrs201398647R129H0.05
COADchr1455145252Missense_MutationnovelA245V0.24
COADchr14551453023'UTRnovel0.24
COADchr1455138208Missense_MutationnovelG61D0.27
GBMchr1455140318Missense_Mutationrs201398647R129H0.52
GBMchr1455145255Frame_Shift_DelnovelS246Yfs*40.13
HNSCchr1455138084Nonsense_MutationnovelQ20*0.28
KIRPchr1455138237Missense_MutationNAP71S0.36
LUADchr1455138064Missense_MutationnovelG13V0.24
LUSCchr1455140317Missense_Mutationrs755491373R129C0.18
PAADchr1455138348Missense_MutationnovelG108C0.04
SKCMchr1455137380In_Frame_DelnovelD3del0.16
STADchr1455138284Frame_Shift_InsnovelA88Gfs*320.54
STADchr1455142693Missense_MutationNAW181R0.06
STADchr1455145213Missense_MutationNAS232N0.22
STADchr1455145193Frame_Shift_InsnovelL228Tfs*30.38
UCECchr14551453503'UTRrs3699802950.19
UCECchr14551453163'UTRnovel0.4
UCECchr14551453973'UTRnovel0.36
UCECchr14551452913'UTRnovel0.55
UCECchr1455138308SilentnovelQ94Q0.4
UCECchr1455140299Missense_MutationnovelP123S0.37
UCECchr1455140274Splice_SitenovelX115_splice0.58
UCECchr1455145213Missense_MutationNAS232N0.27
UCECchr1455138174Frame_Shift_DelnovelP51Qfs*640.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.14440.19769
CHOLDEL0.41670.00040262
KIRPDEL0.16320.085174
MESODEL0.39080.088547
PAADDEL0.05430.11332
PCPGDEL0.11110.044123
THCADEL0.0020.046486
THYMDEL0.01630.063154

Survival Analysis
CancerP-value Q-value
SARC0.03

Kaplan-Meier Survival Analysis

ACC0.023

Kaplan-Meier Survival Analysis

HNSC0.049

Kaplan-Meier Survival Analysis

BRCA0.047

Kaplan-Meier Survival Analysis

TGCT0.043

Kaplan-Meier Survival Analysis

PAAD0.00075

Kaplan-Meier Survival Analysis

BLCA0.016

Kaplan-Meier Survival Analysis

LIHC0.0016

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.018

Kaplan-Meier Survival Analysis

UVM0.00012

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000131981 (Gene tree)
Gene ID
3958
Gene Symbol
LGALS3
Alias
MAC-2|GALIG|LGALS2
Full Name
galectin 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
21,321 bases
Position
chr14:55,124,110-55,145,430
Accession
6563
RBP type
non-canonical RBP
Summary
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
8526926Galectin-3 is a nuclear matrix protein which binds RNA.Biochem Biophys Res Commun1995 Dec 5Wang L-
28262838Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells.Sci Rep2017 Mar 6Coppin Ldoi: 10.1038/srep43927.
2141294Expression of a Mr 32,000 laminin-binding protein messenger RNA in human colon carcinoma correlates with disease progression.Cancer Res1990 Jul 1Mafune K-
1534386Anti-sense RNA of 32-kDa laminin-binding protein inhibits attachment and invasion of a human colon carcinoma cell line.J Surg Res1992 AprMafune K-
8586453The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene.Genomics1995 Nov 20Selvamurugan N-
10961987Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands.J Biol Chem2000 Nov 17Mazurek N-
17047062Characterization of the nuclear import pathways of galectin-3.Cancer Res2006 Oct 15Nakahara S-
17056590Importin-mediated nuclear translocation of galectin-3.J Biol Chem2006 Dec 22Nakahara S-
21494181Loss of galectin-3 expression in mucinous colorectal carcinomas is associated with 5'CpG island methylation in Tunisian patients.Appl Immunohistochem Mol Morphol2011 MayMahmoud LKdoi: 10.1097/PAI.0b013e3181f869bb.
28378189Cleavage and phosphorylation: important post-translational modifications of galectin-3.Cancer Metastasis Rev2017 JunGao Xdoi: 10.1007/s10555-017-9666-0.
28500071Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase.J Immunol2017 Jun 15Nomura Kdoi: 10.4049/jimmunol.1502532
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000556322LGALS3-206599--- (aa)--
ENST00000556263LGALS3-205491--- (aa)--
ENST00000554715LGALS3-204916-ENSP00000451381233 (aa)-G3V3R6
ENST00000553755LGALS3-203630--- (aa)--
ENST00000556438LGALS3-2071734NR_003225-- (aa)--
ENST00000553493LGALS3-202319-ENSP0000045152688 (aa)-G3V407
ENST00000254301LGALS3-2011146-ENSP00000254301250 (aa)-P17931
Gene Model
Click here to download ENSG00000131981's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000131981Body Weight7.79516346031171E-617903300
ENSG00000131981Body Weight2.43757241522572E-717903300
ENSG00000131981Body Weight2.16782873631151E-817903300
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000131981rs764269911455134221GBlood protein levels30072576[0.52-0.69] unit increase0.606EFO_0007937
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131981's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000131981LGALS310082.222ENSMUSG00000050335Lgals39486.667Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001772immunological synapse19706535.IDAComponent
GO:0002548monocyte chemotaxis10925302.IDAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0004864protein phosphatase inhibitor activity24846175.ICFunction
GO:0005515protein binding2402511.19016746.19706535.20812334.21712812.24945728.25315772.25416956.29427412.IPIFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005615extracellular space22664934.23580065.HDAComponent
GO:0005634nucleus7682704.14961764.22761016.IDAComponent
GO:0005681spliceosomal complex-IEAComponent
GO:0005737cytoplasm9447709.14961764.22761016.IDAComponent
GO:0005743mitochondrial inner membrane19016746.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0006397mRNA processing-IEAProcess
GO:0008380RNA splicing-IEAProcess
GO:0009986cell surface-ISSComponent
GO:0016020membrane19946888.HDAComponent
GO:0019863IgE binding2261464.IDAFunction
GO:0019903protein phosphatase binding24846175.IPIFunction
GO:0030246carbohydrate binding-IEAFunction
GO:0030593neutrophil chemotaxis10925302.IDAProcess
GO:0030667secretory granule membrane-TASComponent
GO:0030855epithelial cell differentiation21492153.IEPProcess
GO:0042056chemoattractant activity10925302.IDAFunction
GO:0042129regulation of T cell proliferation8692888.IMPProcess
GO:0043236laminin binding2402511.IDAFunction
GO:0043312neutrophil degranulation-TASProcess
GO:0045087innate immune response-IEAProcess
GO:0045637regulation of myeloid cell differentiation-TASProcess
GO:0045806negative regulation of endocytosis19706535.IDAProcess
GO:0048245eosinophil chemotaxis10925302.IDAProcess
GO:0048246macrophage chemotaxis10925302.IDAProcess
GO:0050860negative regulation of T cell receptor signaling pathway19706535.ISSProcess
GO:0050918positive chemotaxis10925302.IDAProcess
GO:0062023collagen-containing extracellular matrix25037231.27559042.28675934.HDAComponent
GO:0062023collagen-containing extracellular matrix20551380.28327460.HDAComponent
GO:0070062extracellular exosome19056867.19199708.23533145.HDAComponent
GO:0070232regulation of T cell apoptotic process8692888.IDAProcess
GO:0071674mononuclear cell migration10925302.IDAProcess
GO:0071677positive regulation of mononuclear cell migration10925302.IDAProcess
GO:0090073positive regulation of protein homodimerization activity24846175.IDAProcess
GO:0090280positive regulation of calcium ion import10925302.IDAProcess
GO:0101003ficolin-1-rich granule membrane-TASComponent
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors8692888.IMPProcess
GO:1903078positive regulation of protein localization to plasma membrane24846175.IDAProcess
GO:1903614negative regulation of protein tyrosine phosphatase activity24846175.ICProcess
GO:2000521negative regulation of immunological synapse formation19706535.ISSProcess
GO:2001189negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell19706535.ISSProcess
GO:2001200positive regulation of dendritic cell differentiation16116184.IDAProcess
GO:2001237negative regulation of extrinsic apoptotic signaling pathway22761016.IDAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us