EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23444224	Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.	Clin Cancer Res	2013 Apr 15	Martens-de Kemp SR	doi: 10.1158/1078-0432.CCR-12-2539
24001611	MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer.	Cancer Lett	2014 Jan 1	Zhang F	doi: 10.1016/j.canlet.2013.08.037
27140445	Cancer-specific promoters for expression-targeted gene therapy: ran, brms1 and mcm5.	J Gene Med	2016 Jul	Chen X	doi: 10.1002/jgm.2882.
18591255	A survivin-ran complex regulates spindle formation in tumor cells.	Mol Cell Biol	2008 Sep	Xia F	doi: 10.1128/MCB.02039-07
23311631	Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran.	Antioxid Redox Signal	2013 Sep 20	Lu Y	doi: 10.1089/ars.2012.4736
24076388	Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins.	Biochem Biophys Res Commun	2013 Oct 18	Deng L	doi: 10.1016/j.bbrc.2013.09.079
23468463	RanGTPase: a candidate for Myc-mediated cancer progression.	J Natl Cancer Inst	2013 Apr 3	Yuen HF	doi: 10.1093/jnci/djt028
26147304	3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.	PLoS One	2015 Jul 6	Cho SH	doi: 10.1371/journal.pone.0131125
24625450	RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer.	PLoS One	2014 Mar 13	C??ceres-Gorriti KY	doi: 10.1371/journal.pone.0091000
20942967	An essential role for Ran GTPase in epithelial ovarian cancer cell survival.	Mol Cancer	2010 Oct 13	Barr??s V	doi: 10.1186/1476-4598-9-272.
22956174	High Ran level is correlated with poor prognosis in patients with colorectal cancer.	Int J Clin Oncol	2013 Oct	Fan H	doi: 10.1007/s10147-012-0465-x
27716616	Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling.	Oncotarget	2016 Nov 15	Yuen HF	doi: 10.18632/oncotarget.12420.
29750309	Knockdown of Ran GTPase expression inhibits the proliferation and migration of breast cancer cells.	Mol Med Rep	2018 Jul	Sheng C	doi: 10.3892/mmr.2018.8952

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr12	130872851	Missense_Mutation	rs200416921	D18Y	0.13	MMR_HSR1
BLCA	chr12	130874697	Silent	rs769792621	A133A	0.49
BRCA	chr12	130873084	Missense_Mutation	novel	G68D	0.21	MMR_HSR1
BRCA	chr12	130874627	Frame_Shift_Del	NA	*R110Qfs22**	0.23	MMR_HSR1
BRCA	chr12	130874601	Silent	NA	V101V	0.1
BRCA	chr12	130875933	3'UTR	novel		0.3
CESC	chr12	130873106	Silent	novel	L75L	0.17
CESC	chr12	130875949	3'UTR	novel		0.35
CESC	chr12	130875979	3'UTR	novel		0.1
CHOL	chr12	130874580	Silent	novel	S94S	0.34
COAD	chr12	130875903	Missense_Mutation	novel	P210T	0.3
COAD	chr12	130875718	Missense_Mutation	novel	A181V	0.36
COAD	chr12	130875723	Missense_Mutation	NA	A183T	0.29
COAD	chr12	130875997	3'UTR	novel		0.3
COAD	chr12	130872599	Silent	novel	A2A	0.18
COAD	chr12	130874717	Missense_Mutation	NA	R140Q	0.39
DLBC	chr12	130874697	Silent	rs769792621	A133A	0.22
ESCA	chr12	130875667	Missense_Mutation	novel	L164R	0.26
ESCA	chr12	130873025	Silent	novel	H48H	0.38
ESCA	chr12	130873026	Missense_Mutation	novel	P49T	0.39	MMR_HSR1
GBM	chr12	130875773	Silent	rs371816272	H199H	0.31
HNSC	chr12	130874545	Splice_Site	novel	X83_splice	0.28
KIRC	chr12	130872887	Missense_Mutation	NA	H30Y	0.09	MMR_HSR1
KIRP	chr12	130874569	Missense_Mutation	NA	D91N	0.18	MMR_HSR1
KIRP	chr12	130875657	Missense_Mutation	novel	F161V	0.49
LUAD	chr12	130876008	3'UTR	novel		0.13
LUSC	chr12	130876018	3'UTR	novel		0.14
LUSC	chr12	130874553	Silent	novel	C85C	0.1
READ	chr12	130872894	Missense_Mutation	rs11546492	T32I	0.14	MMR_HSR1
READ	chr12	130872835	Splice_Site	NA	X13_splice	0.48
READ	chr12	130874678	Missense_Mutation	NA	K127T	0.38
SKCM	chr12	130873125	Nonsense_Mutation	NA	Q82*	0.25	MMR_HSR1
SKCM	chr12	130874712	Silent	NA	F138F	0.48
SKCM	chr12	130872835	Splice_Site	NA	X13_splice	0.35
STAD	chr12	130874717	Missense_Mutation	NA	R140Q	0.26
STAD	chr12	130874669	Missense_Mutation	novel	V124A	0.24
TGCT	chr12	130872849	Missense_Mutation	novel	G17D	0.18	MMR_HSR1
UCEC	chr12	130874548	Missense_Mutation	novel	Q84K	0.23	MMR_HSR1
UCEC	chr12	130874624	Missense_Mutation	novel	V109A	0.28	MMR_HSR1
UCEC	chr12	130876091	3'UTR	novel		0.31
UCEC	chr12	130875713	Missense_Mutation	NA	M179I	0.46
UCEC	chr12	130876005	3'UTR	novel		0.36
UCEC	chr12	130875946	3'UTR	rs758023706		0.12
UCEC	chr12	130874660	Missense_Mutation	novel	G121V	0.51
UCEC	chr12	130873054	Missense_Mutation	novel	P58H	0.1	MMR_HSR1
UCEC	chr12	130876005	3'UTR	novel		0.38
UCEC	chr12	130874579	Missense_Mutation	NA	S94L	0.48	MMR_HSR1
UCEC	chr12	130875770	Missense_Mutation	novel	E198D	0.42
UCEC	chr12	130876029	3'UTR	rs540859396		0.52
UCEC	chr12	130875905	Silent	rs771898086	P210P	0.39
UCEC	chr12	130875784	Splice_Site	novel	X202_splice	0.15
UCEC	chr12	130875951	3'UTR	novel		0.24
UCEC	chr12	130873013	Silent	novel	G44G	0.39
UCEC	chr12	130875755	Silent	NA	L193L	0.37
UCEC	chr12	130875723	Missense_Mutation	NA	A183T	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.1422	0.22328
BRCA	DEL	0.1574	6.3933e-07
CHOL	DEL	0.1944	0.067545
HNSC	DEL	0.0728	0.22646
LIHC	DEL	0.1243	2.3723e-05
LUAD	DEL	0.157	0.0059643
LUSC	DEL	0.1158	0.038823
PAAD	DEL	0.1739	0.0030251
PRAD	DEL	0.065	0.024258
SKCM	DEL	0.1935	0.00079981
UCEC	DEL	0.0891	0.00053229
UCS	DEL	0.3393	0.033261

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.011	Kaplan-Meier Survival Analysis
SARC	0.0026	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.0037	Kaplan-Meier Survival Analysis
SKCM	0.0035	Kaplan-Meier Survival Analysis
KIRP	0.0035	Kaplan-Meier Survival Analysis
PAAD	0.026	Kaplan-Meier Survival Analysis
BLCA	0.039	Kaplan-Meier Survival Analysis
KICH	0.016	Kaplan-Meier Survival Analysis
UCEC	0.049	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
LUAD	0.0024	Kaplan-Meier Survival Analysis
UVM	0.021	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132341 (Gene tree)
Gene ID: 5901
Gene Symbol: RAN
Alias: ARA24|TC4|Gsp1
Full Name: RAN, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 5,800 bases
Position: chr12:130,871,879-130,877,678
Accession: 9846
RBP type: canonical RBP
Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000444042	MMR_HSR1	PF01926.23	0.00052	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000539498	RAN-209	1659	-	-	- (aa)	-	-
ENST00000543796	RAN-212	2661	-	ENSP00000446215	216 (aa)	-	P62826
ENST00000537745	RAN-208	1065	-	-	- (aa)	-	-
ENST00000536606	RAN-207	572	-	ENSP00000437950	103 (aa)	-	H0YFC6
ENST00000541679	RAN-211	572	-	ENSP00000483687	53 (aa)	-	A0A087X0W0
ENST00000477395	RAN-205	762	-	-	- (aa)	-	-
ENST00000448750	RAN-203	2455	-	ENSP00000396127	234 (aa)	-	J3KQE5
ENST00000535090	RAN-206	657	XM_017019772	ENSP00000444042	198 (aa)	XP_016875261	F5H018
ENST00000392367	RAN-201	780	-	ENSP00000376174	233 (aa)	-	B5MDF5
ENST00000541630	RAN-210	1475	XM_017019773	ENSP00000441210	128 (aa)	XP_016875262	B4DV51
ENST00000392369	RAN-202	1530	-	ENSP00000376176	216 (aa)	-	P62826
ENST00000464211	RAN-204	562	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132341's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG
hsa03013	RNA transport	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000132341	Calcium	5.0170000E-005	-
ENSG00000132341	Panic Disorder	7E-6	19165232

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132341's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000132341	RAN	80	32.121	ENSG00000075785	RAB7A	88	33.333
ENSG00000132341	RAN	83	30.994	ENSG00000119396	RAB14	89	32.727

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132341	RAN	100	92.130	ENSBTAG00000024233	-	100	92.130	Bos_taurus
ENSG00000132341	RAN	100	95.312	ENSCAFG00020003142	-	100	93.056	Canis_lupus_dingo
ENSG00000132341	RAN	100	98.438	ENSCHIG00000025632	-	100	89.352	Capra_hircus
ENSG00000132341	RAN	80	90.244	ENSCSAG00000001906	-	99	96.689	Chlorocebus_sabaeus
ENSG00000132341	RAN	76	91.333	ENSCING00000003944	-	100	86.957	Ciona_intestinalis
ENSG00000132341	RAN	100	99.219	ENSCANG00000004264	-	100	99.074	Colobus_angolensis_palliatus
ENSG00000132341	RAN	100	96.759	ENSCGRG00001009212	-	100	96.759	Cricetulus_griseus_chok1gshd
ENSG00000132341	RAN	100	86.634	ENSCGRG00000007401	-	98	85.581	Cricetulus_griseus_crigri
ENSG00000132341	RAN	100	96.759	ENSCGRG00000019639	Rasl2-9	100	96.759	Cricetulus_griseus_crigri
ENSG00000132341	RAN	100	92.593	ENSDNOG00000031679	-	99	92.593	Dasypus_novemcinctus
ENSG00000132341	RAN	80	84.146	ENSETEG00000010467	-	100	90.000	Echinops_telfairi
ENSG00000132341	RAN	100	91.406	ENSHCOG00000009757	ran	99	89.302	Hippocampus_comes
ENSG00000132341	RAN	70	95.833	ENSLACG00000018793	RAN	97	96.479	Latimeria_chalumnae
ENSG00000132341	RAN	100	97.222	ENSMAUG00000015974	-	100	97.222	Mesocricetus_auratus
ENSG00000132341	RAN	100	100.000	ENSMICG00000000653	-	100	95.154	Microcebus_murinus
ENSG00000132341	RAN	100	93.981	ENSMUSG00000083649	Rasl2-9	100	93.981	Mus_musculus
ENSG00000132341	RAN	100	93.519	MGP_SPRETEiJ_G0030206	Rasl2-9	100	93.519	Mus_spretus
ENSG00000132341	RAN	87	94.350	MGP_SPRETEiJ_G0028777	-	96	96.610	Mus_spretus
ENSG00000132341	RAN	100	81.944	ENSNGAG00000016204	-	92	92.262	Nannospalax_galili
ENSG00000132341	RAN	100	91.406	ENSPMGG00000008616	ran	100	91.667	Periophthalmus_magnuspinnatus
ENSG00000132341	RAN	98	94.949	ENSPEMG00000010658	-	93	96.970	Peromyscus_maniculatus_bairdii
ENSG00000132341	RAN	100	80.184	ENSRBIG00000037389	-	100	80.184	Rhinopithecus_bieti
ENSG00000132341	RAN	95	96.373	ENSRROG00000044174	-	97	98.446	Rhinopithecus_roxellana
ENSG00000132341	RAN	100	94.531	ENSTRUG00000013749	ran	99	92.991	Takifugu_rubripes
ENSG00000132341	RAN	100	92.188	ENSTNIG00000013137	ran	99	91.589	Tetraodon_nigroviridis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000055	ribosomal large subunit export from nucleus	12773398.	IMP	Process
GO:0000056	ribosomal small subunit export from nucleus	12773398.	IMP	Process
GO:0000070	mitotic sister chromatid segregation	29040603.	IMP	Process
GO:0000278	mitotic cell cycle	8421051.	TAS	Process
GO:0000287	magnesium ion binding	11336674.26272610.	IDA	Function
GO:0000785	chromatin	1961752.	IDA	Component
GO:0003682	chromatin binding	1961752.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	8636225.26272610.	IDA	Function
GO:0003924	GTPase activity	10400640.	TAS	Function
GO:0005049	nuclear export signal receptor activity	14681208.	IC	Function
GO:0005515	protein binding	1961752.7603572.9637251.9822603.10078529.10557333.10679025.11290418.11336674.12724356.14681208.16428860.18266911.18591255.18611384.18617507.19098896.20951941.20972448.21139563.21988832.23251006.23435562.23850451.24855949.25416956.26272610.29040603.29130391.29997244.30021884.	IPI	Function
GO:0005525	GTP binding	1961752.11336674.27541860.29040603.	IDA	Function
GO:0005525	GTP binding	18938132.	IMP	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9822603.26308891.	IDA	Component
GO:0005635	nuclear envelope	27541860.	IDA	Component
GO:0005643	nuclear pore	8421051.	NAS	Component
GO:0005654	nucleoplasm	18938132.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	18938132.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	1961752.26308891.	IDA	Component
GO:0005814	centriole	19166812.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006259	DNA metabolic process	8421051.	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0006606	protein import into nucleus	9822603.	IDA	Process
GO:0006606	protein import into nucleus	8636225.	IMP	Process
GO:0006611	protein export from nucleus	16449645.	IDA	Process
GO:0007052	mitotic spindle organization	10408446.	TAS	Process
GO:0010586	miRNA metabolic process	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	TAS	Process
GO:0019003	GDP binding	11336674.27541860.	IDA	Function
GO:0019003	GDP binding	18938132.	IMP	Function
GO:0030496	midbody	19166812.	IDA	Component
GO:0030521	androgen receptor signaling pathway	15572661.	NAS	Process
GO:0032092	positive regulation of protein binding	16449645.	IDA	Process
GO:0032991	protein-containing complex	11336674.	IDA	Component
GO:0032991	protein-containing complex	10557333.	IMP	Component
GO:0035281	pre-miRNA export from nucleus	14681208.	IC	Process
GO:0042307	positive regulation of protein import into nucleus	18691641.	IMP	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042565	RNA nuclear export complex	14681208.	IDA	Component
GO:0043657	host cell	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	Process
GO:0045893	positive regulation of transcription, DNA-templated	15572661.	NAS	Process
GO:0046039	GTP metabolic process	26272610.	IDA	Process
GO:0046982	protein heterodimerization activity	11336674.	IPI	Function
GO:0050681	androgen receptor binding	15572661.	NAS	Function
GO:0051301	cell division	-	IEA	Process
GO:0055037	recycling endosome	24561039.	IDA	Component
GO:0061015	snRNA import into nucleus	8636225.	IMP	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component
GO:0070883	pre-miRNA binding	14681208.	IDA	Function
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:0090543	Flemming body	19166812.	IDA	Component
GO:1902570	protein localization to nucleolus	18938132.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.