EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22057681The expression of PCNA, c-erbB-2, p53, ER and PR as well as atypical hyperplasia in tissues nearby the breast cancer.J Mol Histol2012 FebJia Zdoi: 10.1007/s10735-011-9371-1
21501231Expression form of p53 and PCNA at the invasive front in oral squamous cell carcinoma: correlation with clinicopathological features and prognosis.J Oral Pathol Med2011 OctKato Kdoi: 10.1111/j.1600-0714.2011.01032.x
19130399Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor).Histol Histopathol2009 MarStalinska Ldoi: 10.14670/HH-24.299.
24283290Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway.FEBS J2014 FebLiao XHdoi: 10.1111/febs.12658
18256758Expression of peripheral benzodiazepine receptor, PCNA, and caspase-3 in cells of skin melanoma and squamous cell carcinoma.Bull Exp Biol Med2007 JulRuksha TG-
26339416Expression of CD147, PCNA, VEGF, MMPs and their clinical significance in the giant cell tumor of bones.Int J Clin Exp Pathol2015 Jul 1Han YH-
19885588Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice.Oncol Rep2009 DecXie Y-
23527218Novel interaction between proliferating cell nuclear antigen and HLA I on the surface of tumor cells inhibits NK cell function through NKp44.PLoS One2013Horton NCdoi: 10.1371/journal.pone.0059552
20211058[Effects of genistein on colon cancer cells in vitro and in vivo and its mechanism of action].Zhonghua Zhong Liu Za Zhi2010 JanFan YZ-
21424069Immunohistochemical nuclear staining for p53, PCNA, Ki-67 and bcl-2 in different histologic variants of basal cell carcinoma.Rom J Morphol Embryol2011Mateoiu C-
18510217[Relevance between clinical behavior and bionomical findings of acoustic neuromas].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi2008 FebYang SM-
17982625Down-regulation of tumor suppressor gene PTEN, overexpression of p53, plus high proliferating cell nuclear antigen index predict poor patient outcome of hepatocellular carcinoma after resection.Oncol Rep2007 DecHu TH-
16101161Y-box-binding protein-1 expression is not correlated with p53 expression but with proliferating cell nuclear antigen expression in non-small cell lung cancer.Anticancer Res2005 Sep-OctYoshimatsu T-
18072009Clinical tumor growth and comparison with proliferation markers in non-functioning (inactive) pituitary adenomas.Exp Clin Endocrinol Diabetes2008 FebSaeger W-
29019895The prognostic value of PCNA expression in patients with osteosarcoma: A meta-analysis of 16 studies.Medicine (Baltimore)2017 OctWang Xdoi: 10.1097/MD.0000000000008254.
14669354Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis.World J Gastroenterol2003 DecYue SQ-
26731993High Expression of IncRNA-PCNA-AS1 in Human Gastric Cancer and its Clinical Significances.Clin Lab2015Dang Y-
22556262Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.Cancer Res2012 Jul 1Takawa Mdoi: 10.1158/0008-5472.CAN-11-3701
14612290Clinical significance of expression of p21 and p53 proteins and proliferating cell nuclear antigen in pancreatic cancer.Hepatobiliary Pancreat Dis Int2002 MayDang CX-
19550124Effect of diallyl disulfide on cell cycle arrest of human colon cancer SW480 cells.Ai Zheng2009 FebLiao QJ-
22021614Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44.J Immunol2011 Dec 1Rosental Bdoi: 10.4049/jimmunol.1102267
16888766The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS.Proteomics2006 SepHoelz DJ-
16552335Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1alpha.Pancreas2006 MarWei H-
18312749Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia.Clin Invest Med2008Zhong W-
22622474Elevated levels of proliferating and recently migrated tumor-associated macrophages confer increased aggressiveness and worse outcomes in breast cancer.Ann Surg Oncol2012 NovMukhtar RAdoi: 10.1245/s10434-012-2415-2
15033825p53, Bcl-2, PCNA expression, and apoptotic rates during cervical tumorigenesis.Ann N Y Acad Sci2003 DecAstudillo H-
12532471Expression of p57kip2, Rb protein and PCNA and their relationships with clinicopathology in human pancreatic cancer.World J Gastroenterol2003 FebYue H-
12452062[Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior].Ai Zheng2002 JunJi SQ-
16124066Expression of cell cycle regulator p57kip2, cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: an immunohistochemical study.World J Gastroenterol2005 Aug 28Yue H-
21031434Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer.Prostate2011 May 15Wang Xdoi: 10.1002/pros.21291
24012694Effects of polymorphisms in translesion DNA synthesis genes on lung cancer risk and prognosis in Chinese men.Cancer Epidemiol2013 DecXu HLdoi: 10.1016/j.canep.2013.08.003
22238610Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer.PLoS One2012Zhao Hdoi: 10.1371/journal.pone.0029416
19483288[Multi-slice spiral CT pulmonary perfusion imaging and the expression of VEGF/PCNA in non-small cell lung cancer].Zhong Nan Da Xue Xue Bao Yi Xue Ban2009 MayLiu J-
15967114[18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung.Neoplasia2005 AprMamede M-
18279620[Expression and significance of E-cadherin, CD44v6, and proliferating cell nuclear antigen in non-small cell lung cancer].Ai Zheng2008 FebWeng MX-
20394503Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells.Cancer Invest2010 JulWang Xdoi: 10.3109/07357901003630983.
19481339Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen.Cancer Lett2009 Nov 18Masuo Tdoi: 10.1016/j.canlet.2009.05.001
12088102Expression of c-erbB-2 in node negative breast cancer does not correlate with estrogen receptor status, predictors of hormone responsiveness, or PCNA expression.Neoplasma2002Kol??r Z-
20350215Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN).Pathology2010 AprKaramitopoulou Edoi: 10.3109/00313021003631379.
23542172The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer.Oncogene2014 Mar 13Zhao Hdoi: 10.1038/onc.2013.84
17927850[Expression of sonic hedgehog, EGFR and PCNA proteins in pancreatic cancer and their correlations to cell proliferation].Ai Zheng2007 SepHu WG-
28348485ECRG2 enhances the anti-cancer effects of cisplatin in cisplatin-resistant esophageal cancer cells via upregulation of p53 and downregulation of PCNA.World J Gastroenterol2017 Mar 14Hou XFdoi: 10.3748/wjg.v23.i10.1796.
28814116The dark side of the ring: role of the DNA sliding surface of PCNA.Crit Rev Biochem Mol Biol2017 DecDe March Mdoi: 10.1080/10409238.2017.1364218
28611525Clinical significance of expression of proliferating cell nuclear antigen and E-cadherin in gastric carcinoma.World J Gastroenterol2017 May 28Hu Ldoi: 10.3748/wjg.v23.i20.3721.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr205117519Missense_MutationnovelG178A0.23
BLCAchr205115511Missense_MutationnovelF215C0.09
BLCAchr205117625Missense_MutationNAE143K0.22
BLCAchr205115337Missense_Mutationrs747916514M244I0.19
BLCAchr205115519SilentnovelL212L0.12
BRCAchr205118649Frame_Shift_DelnovelM116Kfs*80.19
BRCAchr205119792Missense_MutationnovelE3Q0.17
BRCAchr2051151143'UTRnovel0.31
BRCAchr2051199185'UTRnovel0.19
CESCchr205117478Nonsense_MutationNAE192*0.37
CESCchr205119600Missense_MutationnovelA67P0.12
CESCchr2051199025'UTRnovel0.19
COADchr205118832Missense_MutationNAD86Y0.34
COADchr205119591Missense_MutationNAV70M0.46
COADchr205117471Missense_MutationNAA194V0.23
GBMchr2051152633'UTRnovel0.25
GBMchr205117630Missense_MutationnovelS141Y0.22
HNSCchr205115554Missense_MutationnovelE201K0.31
KICHchr205118835Missense_MutationnovelE85Q0.52
KIRCchr205118639Missense_MutationNAD120N0.24
KIRCchr205117590Missense_MutationNAI154M0.3
KIRPchr2051151043'UTRnovel0.63
LIHCchr205115477SilentNAT226T0.44
LUADchr205115472Missense_MutationnovelS228N0.12
LUSCchr205117567Missense_MutationnovelC162Y0.35
LUSCchr205115487Missense_MutationnovelS223L0.35
LUSCchr205117557Silentrs17350D165D0.24
PAADchr205119765Missense_MutationnovelL12F0.07
PRADchr205118768Splice_Siters112672560X107_splice0.07
READchr2051151293'UTRnovel0.44
READchr205118821SilentNAT89T0.16
READchr205115338Missense_MutationNAM244R0.44
SKCMchr205118861Missense_Mutationrs760578899S76F0.24
SKCMchr205119583Silentrs267605997L72L0.21
SKCMchr205118667Frame_Shift_DelnovelK110Sfs*50.32
SKCMchr205118778Missense_MutationNAE104K0.28
SKCMchr205118675Nonsense_MutationNAQ108*0.38
STADchr205118862Missense_MutationNAS76P0.44
STADchr205115524Missense_MutationNAY211H0.13
UCECchr205117525Missense_MutationnovelG176E0.36
UCECchr205119690Missense_MutationNAL37M0.28
UCECchr205115476Missense_MutationNAL227I0.39
UCECchr205117516Missense_MutationnovelN179S0.37
UCECchr2051149983'UTRnovel0.32
UCECchr205117614SilentnovelR146R0.24
UCECchr2051151773'UTRnovel0.4
UCECchr205115287Missense_MutationnovelS261Y0.39
UCECchr205117665Splice_SitenovelX130_splice0.36
UCECchr2051151113'UTRnovel0.26
UCECchr205118670Missense_MutationNAE109D0.44
UCECchr205115304Silentrs755609215I255I0.27
UCECchr205119745Silentrs773328092A18A0.3
UCECchr205118612Missense_MutationnovelP129S0.56
UCECchr205119729Missense_MutationnovelN24D0.57

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.13330.030954
LUADDEL0.19960.15188
TGCTDEL0.18670.14117

Survival Analysis
CancerP-value Q-value
THYM0.0062

Kaplan-Meier Survival Analysis

STAD0.021

Kaplan-Meier Survival Analysis

SARC0.05

Kaplan-Meier Survival Analysis

MESO0.00013

Kaplan-Meier Survival Analysis

ACC0.0025

Kaplan-Meier Survival Analysis

PRAD0.048

Kaplan-Meier Survival Analysis

ESCA0.022

Kaplan-Meier Survival Analysis

KIRP0.0027

Kaplan-Meier Survival Analysis

PAAD0.0076

Kaplan-Meier Survival Analysis

CESC0.00071

Kaplan-Meier Survival Analysis

READ0.0037

Kaplan-Meier Survival Analysis

LAML0.0093

Kaplan-Meier Survival Analysis

KICH0.016

Kaplan-Meier Survival Analysis

LIHC0.00012

Kaplan-Meier Survival Analysis

DLBC0.017

Kaplan-Meier Survival Analysis

CHOL0.0099

Kaplan-Meier Survival Analysis

THCA0.017

Kaplan-Meier Survival Analysis

LUAD0.013

Kaplan-Meier Survival Analysis

UVM0.0017

Kaplan-Meier Survival Analysis

OV0.029

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000132646 (Gene tree)
Gene ID
5111
Gene Symbol
PCNA
Alias
N
Full Name
proliferating cell nuclear antigen
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
11,674 bases
Position
chr20:5,114,953-5,126,626
Accession
8729
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15539445Molecular markers for the assessment of postnatal male germ cell development in the mouse.Hum Reprod2005 JanJarvis S-
19319956Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer.J Med Virol2009 MayFay Jdoi: 10.1002/jmv.21406.
18765568Recruitment of mismatch repair proteins to the site of DNA damage in human cells.J Cell Sci2008 Oct 1Hong Zdoi: 10.1242/jcs.026393
10656792DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length.J Mol Biol2000 Jan 28Mossi R-
16226712Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.Biochem Biophys Res Commun2005 Dec 2Niture SK-
19816296Recombinant human bone morphogenetic protein-4 (BMP-4)-stimulated cell differentiation and bone formation within the expanding calvarial suture in rats.J Craniofac Surg2009 SepShen Qdoi: 10.1097/SCS.0b013e3181b09cc1.
21253613Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries.PLoS One2011 Jan 6Xu Bdoi: 10.1371/journal.pone.0016046.
23680657Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage.Am J Pathol2013 JulFogarty NMdoi: 10.1016/j.ajpath.2013.03.016
25883228TIF-IA and Ebp1 regulate RNA synthesis in T cells.Blood2015 Apr 16Saudemont Adoi: 10.1182/blood-2015-03-630780.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000379160PCNA-2021359-ENSP00000368458261 (aa)-P12004
ENST00000379143PCNA-2011344-ENSP00000368438261 (aa)-P12004
Gene Model
Click here to download ENSG00000132646's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
hsa03410Base excision repairKEGG
hsa03420Nucleotide excision repairKEGG
hsa03430Mismatch repairKEGG
hsa04110Cell cycleKEGG
hsa04530Tight junctionKEGG
hsa05161Hepatitis BKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132646's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000132646PCNA9947.893WBGene00003955pcn-19947.893Caenorhabditis_elegans
ENSG00000132646PCNA9935.521YBR088CPOL3010035.521Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TASProcess
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity11005803.IDAFunction
GO:0000723telomere maintenance-TASProcess
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000785chromatin23277426.IDAComponent
GO:0003682chromatin binding23277426.24939902.IDAFunction
GO:0003684damaged DNA binding24939902.IDAFunction
GO:0005515protein binding9305916.10873631.11005803.11022036.14657243.15225546.15358233.15543136.15550930.15576034.15805117.16000169.16189514.16482215.16510448.16826239.17955473.18316726.18499658.18692475.18719106.19150984.19419956.19505873.19730436.20457750.20605778.20733054.20849852.21549307.21628590.21856198.21988832.21994455.22021614.22153967.22634751.22681887.22704558.22705370.22759634.22894931.22902628.23000965.23042605.23042607.23527218.24267889.24561620.24695737.25416956.26496610.26751069.27107012.27906959.28191891.28777577.29290612.29997244.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus15494374.19734146.24939902.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005657replication fork9774970.IDAComponent
GO:0005663DNA replication factor C complex2565339.TASComponent
GO:0005813centrosome18331714.IDAComponent
GO:0006272leading strand elongation21873635.IBAProcess
GO:0006283transcription-coupled nucleotide-excision repair-TASProcess
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TASProcess
GO:0006297nucleotide-excision repair, DNA gap filling-TASProcess
GO:0006298mismatch repair21873635.IBAProcess
GO:0006298mismatch repair11005803.IDAProcess
GO:0006298mismatch repair-TASProcess
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TASProcess
GO:0007507heart development-IEAProcess
GO:0008283cell proliferation2565339.TASProcess
GO:0016032viral process-IEAProcess
GO:0016567protein ubiquitination-TASProcess
GO:0016604nuclear body-IDAComponent
GO:0019899enzyme binding24115439.IPIFunction
GO:0019985translesion synthesis21873635.IBAProcess
GO:0019985translesion synthesis20129063.IDAProcess
GO:0019985translesion synthesis-TASProcess
GO:0030331estrogen receptor binding-IEAFunction
GO:0030337DNA polymerase processivity factor activity21873635.IBAFunction
GO:0030855epithelial cell differentiation21492153.IEPProcess
GO:0030894replisome24115439.TASComponent
GO:0030971receptor tyrosine kinase binding17115032.IPIFunction
GO:0031297replication fork processing24115439.ISSProcess
GO:0032077positive regulation of deoxyribonuclease activity19443450.IDAProcess
GO:0032139dinucleotide insertion or deletion binding11005803.IDAFunction
GO:0032201telomere maintenance via semi-conservative replication-TASProcess
GO:0032355response to estradiol-IEAProcess
GO:0032405MutLalpha complex binding11005803.IDAFunction
GO:0033683nucleotide-excision repair, DNA incision-TASProcess
GO:0034644cellular response to UV24939902.IDAProcess
GO:0035035histone acetyltransferase binding24939902.IPIFunction
GO:0042276error-prone translesion synthesis-TASProcess
GO:0042769DNA damage response, detection of DNA damage-TASProcess
GO:0042802identical protein binding15805117.25416956.IPIFunction
GO:0043596nuclear replication fork15543136.21383955.IDAComponent
GO:0043626PCNA complex21873635.IBAComponent
GO:0043626PCNA complex24939902.IDAComponent
GO:0044849estrous cycle-IEAProcess
GO:0045739positive regulation of DNA repair24939902.IMPProcess
GO:0045740positive regulation of DNA replication24939902.IMPProcess
GO:0046686response to cadmium ion-IEAProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0070182DNA polymerase binding19995904.24939902.IPIFunction
GO:0070301cellular response to hydrogen peroxide-IEAProcess
GO:0070557PCNA-p21 complex18794347.IDAComponent
GO:0070987error-free translesion synthesis-TASProcess
GO:0071548response to dexamethasone-IEAProcess
GO:0097421liver regeneration-IEAProcess
GO:1902065response to L-glutamate-IEAProcess
GO:1902990mitotic telomere maintenance via semi-conservative replication24115439.ISSProcess
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