EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr20	23354037	5'UTR	novel		0.11
BRCA	chr20	23354134	Silent	NA	R31R	0.18
CESC	chr20	23354168	Missense_Mutation	novel	A43T	0.22	NTF2
CESC	chr20	23354222	Missense_Mutation	novel	F61L	0.14	NTF2
CESC	chr20	23354715	3'UTR	novel		0.22
COAD	chr20	23354106	Missense_Mutation	rs149042553	N22S	0.23	NTF2
COAD	chr20	23354311	Silent	rs749421513	T90T	0.38
COAD	chr20	23354753	3'UTR	novel		0.3
COAD	chr20	23354119	Silent	NA	T26T	0.32
COAD	chr20	23354159	Missense_Mutation	novel	M40L	0.27	NTF2
COAD	chr20	23354652	3'UTR	rs539571951		0.13
COAD	chr20	23354169	Missense_Mutation	NA	A43V	0.17	NTF2
COAD	chr20	23353980	Splice_Site	novel		0.71
COAD	chr20	23354135	Missense_Mutation	NA	R32W	0.6	NTF2
ESCA	chr20	23354533	3'UTR	novel		0.17
KIRC	chr20	23354533	3'UTR	novel		0.36
KIRP	chr20	23354091	Missense_Mutation	novel	A17D	0.15	NTF2
LGG	chr20	23354538	3'UTR	novel		0.18
LIHC	chr20	23354570	3'UTR	novel		0.33
LIHC	chr20	23354648	3'UTR	novel		0.49
LIHC	chr20	23354030	5'UTR	novel		0.48
LUAD	chr20	23354069	Missense_Mutation	NA	V10M	0.13
LUAD	chr20	23354380	Missense_Mutation	novel	F113L	0.1	NTF2
LUSC	chr20	23354319	Missense_Mutation	novel	V93G	0.28	NTF2
LUSC	chr20	23354245	Missense_Mutation	NA	S68R	0.09	NTF2
OV	chr20	23354093	Missense_Mutation	NA	E18K	0.06	NTF2
PAAD	chr20	23354442	Missense_Mutation	novel	R134H	0.2	NTF2
READ	chr20	23354481	3'UTR	novel		0.53
READ	chr20	23354570	3'UTR	novel		0.3
SKCM	chr20	23354199	Missense_Mutation	NA	S53L	0.34	NTF2
SKCM	chr20	23354314	Silent	novel	V91V	0.3
SKCM	chr20	23354466	3'UTR	novel		0.38
SKCM	chr20	23354252	Nonsense_Mutation	NA	Q71*	0.19	NTF2
STAD	chr20	23354132	Missense_Mutation	rs747429249	R31W	0.31	NTF2
STAD	chr20	23354288	Frame_Shift_Ins	novel	*A84Sfs19**	0.38	NTF2
STAD	chr20	23354360	Missense_Mutation	NA	R107W	0.18	NTF2
UCEC	chr20	23354281	Silent	novel	V80V	0.27
UCEC	chr20	23354470	3'UTR	novel		0.51
UCEC	chr20	23354269	Silent	novel	D76D	0.17
UCEC	chr20	23354310	Missense_Mutation	rs780312087	T90M	0.45	NTF2
UCEC	chr20	23354131	Silent	NA	K30K	0.17
UCEC	chr20	23354360	Missense_Mutation	NA	R107W	0.49	NTF2
UCEC	chr20	23354426	Missense_Mutation	rs767786208	A129T	0.36	NTF2
UCEC	chr20	23354398	Silent	novel	A119A	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUAD	AMP	0.2694	0.19771
PAAD	AMP	0.125	0.0668

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.00015	Kaplan-Meier Survival Analysis
ESCA	0.014	Kaplan-Meier Survival Analysis
KIRP	0.00098	Kaplan-Meier Survival Analysis
READ	0.034	Kaplan-Meier Survival Analysis
LIHC	0.0014	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.015	Kaplan-Meier Survival Analysis
UVM	0.0083	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132661 (Gene tree)
Gene ID: 29107
Gene Symbol: NXT1
Alias: P15|MTR2
Full Name: nuclear transport factor 2 like export factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,042 bases
Position: chr20:23,350,736-23,354,777
Accession: 15913
RBP type: canonical RBP
Summary: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000254998	NTF2	PF02136.20	2.2e-29	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25628355	NTF2-like domain of Tap plays a critical role in cargo mRNA recognition and export.	Nucleic Acids Res	2015 Feb 18	Katahira J	doi: 10.1093/nar/gkv039
25628361	The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA.	Nucleic Acids Res	2015 Feb 18	Aibara S	doi: 10.1093/nar/gkv032
11073998	TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.	Mol Cell Biol	2000 Dec	Herold A	-
19165146	Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.	EMBO J	2009 Mar 4	Katahira J	doi: 10.1038/emboj.2009.5
17056718	Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription.	Proc Natl Acad Sci U S A	2006 Oct 31	Gwizdek C	-
26144233	Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.	Acta Crystallogr F Struct Biol Commun	2015 Jul	Aibara S	doi: 10.1107/S2053230X15008766
11579093	RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex.	J Biol Chem	2001 Nov 30	Levesque L	-
10848583	RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro.	Mol Cell Biol	2000 Jul	Ossareh-Nazari B	-
18630756	Nuclear RNA export and its importance in abiotic stress responses of plants.	Curr Top Microbiol Immunol	2008	Chinnusamy V	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000254998	NXT1-201	1123	XM_011529230	ENSP00000254998	140 (aa)	XP_011527532	Q9UKK6

Gene Model

Click here to download ENSG00000132661's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
hsa05164	Influenza A	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132661's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000132661	NXT1	99	75.362	ENSG00000101888	NXT2	97	75.362

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132661	NXT1	100	97.857	ENSAMEG00000018729	NXT1	100	97.857	Ailuropoda_melanoleuca
ENSG00000132661	NXT1	100	99.286	ENSANAG00000010003	NXT1	100	99.286	Aotus_nancymaae
ENSG00000132661	NXT1	99	97.842	ENSBTAG00000004993	NXT1	99	97.842	Bos_taurus
ENSG00000132661	NXT1	100	99.286	ENSCJAG00000044836	NXT1	100	99.286	Callithrix_jacchus
ENSG00000132661	NXT1	100	96.429	ENSTSYG00000007592	NXT1	100	96.429	Carlito_syrichta
ENSG00000132661	NXT1	100	97.143	ENSCAPG00000012780	NXT1	100	97.143	Cavia_aperea
ENSG00000132661	NXT1	100	97.143	ENSCPOG00000008817	NXT1	100	97.143	Cavia_porcellus
ENSG00000132661	NXT1	100	99.286	ENSCCAG00000015478	NXT1	100	99.286	Cebus_capucinus
ENSG00000132661	NXT1	100	100.000	ENSCATG00000019026	NXT1	100	100.000	Cercocebus_atys
ENSG00000132661	NXT1	100	97.857	ENSCLAG00000012493	NXT1	100	97.857	Chinchilla_lanigera
ENSG00000132661	NXT1	100	100.000	ENSCSAG00000018678	NXT1	100	100.000	Chlorocebus_sabaeus
ENSG00000132661	NXT1	100	92.143	ENSCHOG00000007142	NXT1	100	92.143	Choloepus_hoffmanni
ENSG00000132661	NXT1	100	100.000	ENSCANG00000001309	NXT1	100	100.000	Colobus_angolensis_palliatus
ENSG00000132661	NXT1	100	78.322	ENSCGRG00001014411	-	100	78.322	Cricetulus_griseus_chok1gshd
ENSG00000132661	NXT1	100	97.857	ENSCGRG00001007062	-	100	97.857	Cricetulus_griseus_chok1gshd
ENSG00000132661	NXT1	100	78.322	ENSCGRG00000005554	-	100	78.322	Cricetulus_griseus_crigri
ENSG00000132661	NXT1	100	97.857	ENSCGRG00000012771	-	100	97.857	Cricetulus_griseus_crigri
ENSG00000132661	NXT1	99	57.857	ENSDNOG00000040022	-	98	57.857	Dasypus_novemcinctus
ENSG00000132661	NXT1	100	92.143	ENSDNOG00000015112	-	100	92.143	Dasypus_novemcinctus
ENSG00000132661	NXT1	100	98.571	ENSDORG00000024690	Nxt1	100	98.571	Dipodomys_ordii
ENSG00000132661	NXT1	100	96.429	ENSEASG00005002553	NXT1	100	96.429	Equus_asinus_asinus
ENSG00000132661	NXT1	100	96.429	ENSECAG00000035032	NXT1	100	96.429	Equus_caballus
ENSG00000132661	NXT1	99	94.928	ENSEEUG00000013818	NXT1	99	94.928	Erinaceus_europaeus
ENSG00000132661	NXT1	100	98.571	ENSFCAG00000006482	NXT1	100	98.571	Felis_catus
ENSG00000132661	NXT1	99	98.561	ENSFDAG00000012027	-	99	98.561	Fukomys_damarensis
ENSG00000132661	NXT1	96	81.481	ENSFDAG00000006553	-	97	81.481	Fukomys_damarensis
ENSG00000132661	NXT1	100	100.000	ENSGGOG00000012539	-	100	100.000	Gorilla_gorilla
ENSG00000132661	NXT1	76	84.906	ENSGGOG00000022722	-	80	84.906	Gorilla_gorilla
ENSG00000132661	NXT1	100	98.571	ENSHGLG00000007882	NXT1	100	98.571	Heterocephalus_glaber_female
ENSG00000132661	NXT1	100	98.571	ENSHGLG00100015157	NXT1	100	98.571	Heterocephalus_glaber_male
ENSG00000132661	NXT1	100	96.429	ENSSTOG00000026331	NXT1	100	96.429	Ictidomys_tridecemlineatus
ENSG00000132661	NXT1	100	98.571	ENSJJAG00000012022	-	100	98.571	Jaculus_jaculus
ENSG00000132661	NXT1	100	80.714	ENSJJAG00000013926	-	100	80.714	Jaculus_jaculus
ENSG00000132661	NXT1	100	95.000	ENSLAFG00000029098	NXT1	100	95.000	Loxodonta_africana
ENSG00000132661	NXT1	100	100.000	ENSMFAG00000019296	NXT1	100	100.000	Macaca_fascicularis
ENSG00000132661	NXT1	100	100.000	ENSMMUG00000022386	NXT1	100	100.000	Macaca_mulatta
ENSG00000132661	NXT1	100	100.000	ENSMNEG00000027745	NXT1	100	100.000	Macaca_nemestrina
ENSG00000132661	NXT1	100	100.000	ENSMLEG00000027268	NXT1	100	100.000	Mandrillus_leucophaeus
ENSG00000132661	NXT1	100	97.857	ENSMAUG00000004141	Nxt1	100	97.857	Mesocricetus_auratus
ENSG00000132661	NXT1	100	96.429	ENSMICG00000044853	NXT1	100	96.429	Microcebus_murinus
ENSG00000132661	NXT1	100	95.714	ENSMOCG00000018712	Nxt1	100	95.714	Microtus_ochrogaster
ENSG00000132661	NXT1	100	98.571	MGP_CAROLIEiJ_G0024408	Nxt1	100	98.571	Mus_caroli
ENSG00000132661	NXT1	100	98.571	ENSMUSG00000036992	Nxt1	100	98.571	Mus_musculus
ENSG00000132661	NXT1	100	97.143	MGP_PahariEiJ_G0025851	Nxt1	100	97.143	Mus_pahari
ENSG00000132661	NXT1	100	98.571	MGP_SPRETEiJ_G0025326	Nxt1	100	98.571	Mus_spretus
ENSG00000132661	NXT1	100	98.571	ENSMPUG00000019260	NXT1	100	98.571	Mustela_putorius_furo
ENSG00000132661	NXT1	100	97.857	ENSMLUG00000006881	NXT1	100	97.857	Myotis_lucifugus
ENSG00000132661	NXT1	100	98.571	ENSNGAG00000000803	Nxt1	100	98.571	Nannospalax_galili
ENSG00000132661	NXT1	100	96.429	ENSOPRG00000006167	NXT1	100	96.429	Ochotona_princeps
ENSG00000132661	NXT1	100	97.143	ENSODEG00000019900	NXT1	100	97.143	Octodon_degus
ENSG00000132661	NXT1	100	97.857	ENSOCUG00000025924	NXT1	100	97.857	Oryctolagus_cuniculus
ENSG00000132661	NXT1	100	97.143	ENSOGAG00000000717	NXT1	99	97.143	Otolemur_garnettii
ENSG00000132661	NXT1	100	100.000	ENSPPAG00000020479	NXT1	100	100.000	Pan_paniscus
ENSG00000132661	NXT1	100	98.571	ENSPPRG00000021392	NXT1	100	98.571	Panthera_pardus
ENSG00000132661	NXT1	100	98.571	ENSPTIG00000003788	NXT1	100	98.571	Panthera_tigris_altaica
ENSG00000132661	NXT1	100	100.000	ENSPTRG00000013319	NXT1	100	100.000	Pan_troglodytes
ENSG00000132661	NXT1	100	100.000	ENSPANG00000023254	NXT1	100	100.000	Papio_anubis
ENSG00000132661	NXT1	100	97.857	ENSPEMG00000010397	Nxt1	100	97.857	Peromyscus_maniculatus_bairdii
ENSG00000132661	NXT1	100	100.000	ENSPPYG00000010765	NXT1	100	100.000	Pongo_abelii
ENSG00000132661	NXT1	100	95.714	ENSPCAG00000009373	-	100	95.714	Procavia_capensis
ENSG00000132661	NXT1	100	98.571	ENSPCOG00000025624	NXT1	99	98.571	Propithecus_coquereli
ENSG00000132661	NXT1	100	97.857	ENSPVAG00000014055	NXT1	100	97.857	Pteropus_vampyrus
ENSG00000132661	NXT1	100	97.857	ENSRNOG00000004700	Nxt1	100	97.857	Rattus_norvegicus
ENSG00000132661	NXT1	100	100.000	ENSRBIG00000021433	NXT1	100	100.000	Rhinopithecus_bieti
ENSG00000132661	NXT1	100	100.000	ENSRROG00000026657	NXT1	100	100.000	Rhinopithecus_roxellana
ENSG00000132661	NXT1	100	99.286	ENSSBOG00000036378	NXT1	100	99.286	Saimiri_boliviensis_boliviensis
ENSG00000132661	NXT1	100	97.143	ENSSARG00000007842	NXT1	100	97.143	Sorex_araneus
ENSG00000132661	NXT1	99	95.683	ENSSSCG00000007119	NXT1	99	95.683	Sus_scrofa
ENSG00000132661	NXT1	100	99.286	ENSTBEG00000012251	NXT1	100	99.286	Tupaia_belangeri
ENSG00000132661	NXT1	99	98.561	ENSTTRG00000011348	NXT1	99	98.561	Tursiops_truncatus
ENSG00000132661	NXT1	100	97.857	ENSUAMG00000021860	NXT1	100	97.857	Ursus_americanus
ENSG00000132661	NXT1	100	97.857	ENSUMAG00000004062	NXT1	100	97.857	Ursus_maritimus
ENSG00000132661	NXT1	100	98.571	ENSVVUG00000012091	NXT1	100	98.571	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	11566096.11583626.12483225.14729961.16189514.17267598.19060904.23299939.25416956.	IPI	Function
GO:0005643	nuclear pore	10567585.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	10567585.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0006913	nucleocytoplasmic transport	21873635.	IBA	Process
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0016607	nuclear speck	-	IEA	Component
GO:0044613	nuclear pore central transport channel	21873635.	IBA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.