EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21496299	Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells.	Reprod Biol Endocrinol	2011 Apr 16	Alekseev OM	doi: 10.1186/1477-7827-9-50.
20164540	Analysis of the expression of human tumor antigens in ovarian cancer tissues.	Cancer Biomark	2010	Ali-Fehmi R	doi: 10.3233/CBM-2009-0117.
28173777	microRNA-29c inhibits cell proliferation by targeting NASP in human gastric cancer.	BMC Cancer	2017 Feb 7	Yu B	doi: 10.1186/s12885-017-3096-9.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	45584186	Missense_Mutation	novel	E14K	0.36
BLCA	chr1	45618064	Missense_Mutation	NA	E764K	0.42
BLCA	chr1	45615132	Missense_Mutation	novel	Y596H	0.45
BLCA	chr1	45607675	Missense_Mutation	novel	R255T	0.22
BLCA	chr1	45606570	Missense_Mutation	novel	E130Q	0.62
BLCA	chr1	45602271	Missense_Mutation	novel	E42K	0.2
BLCA	chr1	45606522	Missense_Mutation	NA	H114N	0.26
BLCA	chr1	45616383	Frame_Shift_Del	novel	S690*	0.39
BLCA	chr1	45613143	Intron	novel		0.32
BLCA	chr1	45607662	Missense_Mutation	NA	Q251K	0.16
BRCA	chr1	45615028	Missense_Mutation	novel	A561V	0.36
BRCA	chr1	45614128	Silent	NA	G513G	0.12
BRCA	chr1	45613181	Missense_Mutation	novel	S480L	0.41
BRCA	chr1	45607665	Missense_Mutation	novel	E252Q	0.14
BRCA	chr1	45607320	Splice_Site	NA	X137_splice	0.16
CESC	chr1	45607854	Missense_Mutation	NA	E315Q	0.34
CESC	chr1	45607448	Silent	novel	E179E	0.1
CESC	chr1	45607449	Frame_Shift_Ins	novel	*K180Tfs14**	0.1
CESC	chr1	45607374	Missense_Mutation	rs759202853	E155Q	0.23
CESC	chr1	45613135	Intron	novel		0.23
CESC	chr1	45606507	Missense_Mutation	NA	A109T	0.33
CESC	chr1	45607318	Splice_Region	novel		0.51
CESC	chr1	45615328	Nonsense_Mutation	novel	E627*	0.42
CESC	chr1	45614097	Missense_Mutation	NA	S503C	0.61
COAD	chr1	45614137	Silent	NA	E516E	0.31
COAD	chr1	45606579	Missense_Mutation	novel	D133N	0.23
COAD	chr1	45584076	5'UTR	novel		0.15
COAD	chr1	45617481	Missense_Mutation	NA	S726C	0.38
COAD	chr1	45617482	Missense_Mutation	NA	S726T	0.38
COAD	chr1	45616634	Silent	novel	S696S	0.4
COAD	chr1	45608313	Missense_Mutation	novel	E468K	0.39
COAD	chr1	45615044	Silent	novel	Q566Q	0.32
COAD	chr1	45618265	3'UTR	NA		0.33
COAD	chr1	45584054	5'Flank	novel		0.23
COAD	chr1	45613044	Intron	novel		0.2
COAD	chr1	45614344	Silent	rs762794083	L548L	0.15
COAD	chr1	45618265	3'UTR	NA		0.58
COAD	chr1	45615337	Missense_Mutation	NA	G630R	0.4
COAD	chr1	45615054	Missense_Mutation	novel	N570H	0.4
COAD	chr1	45607383	Frame_Shift_Del	NA	*T160Qfs29**	0.25
COAD	chr1	45606507	Missense_Mutation	NA	A109T	0.31
DLBC	chr1	45615160	Missense_Mutation	NA	A605V	0.39
ESCA	chr1	45618213	3'UTR	novel		0.33
ESCA	chr1	45607516	Missense_Mutation	novel	T202S	0.49
GBM	chr1	45615045	Missense_Mutation	novel	S567A	0.34
GBM	chr1	45617562	Missense_Mutation	novel	N753D	0.24
GBM	chr1	45615183	Missense_Mutation	novel	V613F	0.12
GBM	chr1	45615461	Missense_Mutation	novel	K671I	0.13
GBM	chr1	45602337	Missense_Mutation	novel	N64H	0.05
HNSC	chr1	45608153	Silent	novel	V414V	0.19
HNSC	chr1	45607857	Nonsense_Mutation	novel	E316*	0.08
KIRC	chr1	45615074	Silent	novel	L576L	0.19
KIRP	chr1	45607381	In_Frame_Del	novel	K158_S164del	0.12
KIRP	chr1	45607533	Frame_Shift_Ins	novel	*T209Nfs3**	0.51
LAML	chr1	45614312	Nonsense_Mutation	novel	Q538*	0.08
LIHC	chr1	45607977	Missense_Mutation	NA	A356S	0.18
LIHC	chr1	45617522	Silent	NA	P739P	0.33
LIHC	chr1	45615105	Missense_Mutation	novel	H587Y	0.46
LUAD	chr1	45615382	Missense_Mutation	NA	L645V	0.16
LUAD	chr1	45613244	Missense_Mutation	novel	N501I	0.33
LUAD	chr1	45607779	Missense_Mutation	NA	G290C	0.62
LUAD	chr1	45602283	Silent	novel	L46L	0.11
LUSC	chr1	45607335	Missense_Mutation	NA	E142Q	0.09
MESO	chr1	45615185	Silent	novel	V613V	0.23
OV	chr1	45607720	Missense_Mutation	novel	I270T	0.08
OV	chr1	45617509	Missense_Mutation	NA	A735V	0.13
OV	chr1	45615377	Missense_Mutation	NA	K643R	0.42
OV	chr1	45607867	Missense_Mutation	novel	V319D	0.06
OV	chr1	45615365	Missense_Mutation	rs546656039	I639T	0.28
PAAD	chr1	45618123	Silent	novel	V783V	0.23
PRAD	chr1	45608060	Silent	rs761576032	P383P	0.13
PRAD	chr1	45607986	Missense_Mutation	NA	A359T	0.26
READ	chr1	45615014	Missense_Mutation	novel	E556D	0.18
SARC	chr1	45614181	Missense_Mutation	novel	R531K	0.41
SKCM	chr1	45617472	Missense_Mutation	novel	E723K	0.38
SKCM	chr1	45607779	Missense_Mutation	rs201219258	G290S	0.16
SKCM	chr1	45604981	Silent	novel	F88F	0.5
SKCM	chr1	45607614	Missense_Mutation	NA	E235K	0.24
SKCM	chr1	45608034	Missense_Mutation	rs370255034	P375S	0.27
SKCM	chr1	45591242	Missense_Mutation	NA	P27A	0.2
SKCM	chr1	45615200	Missense_Mutation	novel	M618I	0.83
SKCM	chr1	45615201	Missense_Mutation	novel	A619T	0.83
SKCM	chr1	45608169	Missense_Mutation	novel	P420S	0.24
SKCM	chr1	45608034	Missense_Mutation	rs370255034	P375S	0.21
STAD	chr1	45607383	Frame_Shift_Del	NA	*T160Qfs29**	0.17
STAD	chr1	45602340	Missense_Mutation	NA	A65T	0.26
STAD	chr1	45607383	Frame_Shift_Del	NA	*T160Qfs29**	0.28
STAD	chr1	45607877	Missense_Mutation	NA	E322D	0.27
STAD	chr1	45607359	Missense_Mutation	novel	A150T	0.39
STAD	chr1	45607848	Missense_Mutation	rs774362498	E313K	0.18
STAD	chr1	45617509	Missense_Mutation	NA	A735V	0.23
STAD	chr1	45607383	Frame_Shift_Del	NA	*T160Qfs29**	0.23
STAD	chr1	45607383	Frame_Shift_Del	NA	*T160Qfs29**	0.27
STAD	chr1	45591230	Missense_Mutation	novel	D23H	0.07
TGCT	chr1	45607486	Missense_Mutation	novel	A192V	0.23
UCEC	chr1	45607895	Silent	rs756510043	A328A	0.5
UCEC	chr1	45605012	Missense_Mutation	novel	A99T	0.08
UCEC	chr1	45607450	Missense_Mutation	novel	K180R	0.39
UCEC	chr1	45607577	Silent	rs746616499	P222P	0.33
UCEC	chr1	45607549	Missense_Mutation	novel	A213V	0.51
UCEC	chr1	45608243	Silent	novel	A444A	0.31
UCEC	chr1	45615144	Missense_Mutation	novel	Y600H	0.43
UCEC	chr1	45607383	Missense_Mutation	novel	K158Q	0.07
UCEC	chr1	45608246	Silent	novel	Q445Q	0.4
UCEC	chr1	45600406	Intron	novel		0.32
UCEC	chr1	45607847	Silent	rs770852530	D312D	0.33
UCEC	chr1	45617572	Missense_Mutation	rs749672551	S756L	0.36
UCEC	chr1	45584043	5'Flank	novel		0.17
UCEC	chr1	45613001	Intron	novel		0.42
UCEC	chr1	45615185	Silent	novel	V613V	0.29
UCEC	chr1	45617572	Missense_Mutation	rs749672551	S756L	0.53
UCEC	chr1	45618213	3'UTR	novel		0.29
UCEC	chr1	45613123	Intron	novel		0.27
UCEC	chr1	45607717	Missense_Mutation	novel	S269N	0.53
UCEC	chr1	45618265	3'UTR	NA		0.19
UCEC	chr1	45618507	3'UTR	novel		0.54
UCEC	chr1	45607344	Nonsense_Mutation	novel	E145*	0.34
UCEC	chr1	45607737	Nonsense_Mutation	novel	E276*	0.52
UCEC	chr1	45607383	Frame_Shift_Del	NA	*T160Qfs29**	0.39
UCEC	chr1	45615305	Missense_Mutation	rs779995067	A619V	0.16
UCEC	chr1	45606507	Missense_Mutation	NA	A109T	0.26
UCEC	chr1	45608228	Silent	novel	V439V	0.07
UCEC	chr1	45614321	Missense_Mutation	novel	A541T	0.37
UCEC	chr1	45618429	3'UTR	rs190702809		0.65
UCEC	chr1	45600432	Intron	novel		0.17
UCEC	chr1	45613023	Intron	novel		0.33
UCEC	chr1	45607383	Frame_Shift_Del	NA	*T160Qfs29**	0.5
UCEC	chr1	45615014	Missense_Mutation	NA	E556D	0.26
UCEC	chr1	45615361	Nonsense_Mutation	novel	E638*	0.21
UCEC	chr1	45618309	3'UTR	novel		0.13
UCEC	chr1	45608060	Silent	rs761576032	P383P	0.26
UCEC	chr1	45604973	Missense_Mutation	novel	E86K	0.05
UCEC	chr1	45607574	Silent	novel	G221G	0.06
UCEC	chr1	45615391	Missense_Mutation	rs199692248	E648K	0.35
UCEC	chr1	45607392	Missense_Mutation	novel	E161K	0.26
UCEC	chr1	45618265	3'UTR	NA		0.44
UCEC	chr1	45607793	Missense_Mutation	NA	E294D	0.42
UCEC	chr1	45607480	Missense_Mutation	novel	K190T	0.41
UCEC	chr1	45607679	Silent	novel	E256E	0.28
UCEC	chr1	45607866	Missense_Mutation	novel	V319I	0.45
UCS	chr1	45613190	Missense_Mutation	novel	D483G	0.07

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0833	0.011841
TGCT	DEL	0.16	0.00046313

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0085	Kaplan-Meier Survival Analysis
KIRC	0.00024	Kaplan-Meier Survival Analysis
STAD	0.013	Kaplan-Meier Survival Analysis
SARC	0.0009	Kaplan-Meier Survival Analysis
MESO	0.00019	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.026	Kaplan-Meier Survival Analysis
KIRP	0.017	Kaplan-Meier Survival Analysis
CESC	0.0041	Kaplan-Meier Survival Analysis
READ	0.0083	Kaplan-Meier Survival Analysis
UCEC	0.035	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.048	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00085	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132780 (Gene tree)
Gene ID: 4678
Gene Symbol: NASP
Alias: FLB7527|FLJ31599|FLJ35510|MGC19722|MGC20372|MGC2297|DKFZp547F162|PRO1999
Full Name: nuclear autoantigenic sperm protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 35,061 bases
Position: chr1:45,583,846-45,618,906
Accession: 7644
RBP type: non-canonical RBP
Summary: This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000350030	NASP-201	3207	XM_005270888	ENSP00000255120	788 (aa)	XP_005270945	P49321
ENST00000530073	NASP-218	2740	-	-	- (aa)	-	-
ENST00000531532	NASP-220	554	-	ENSP00000436778	56 (aa)	-	E9PKR5
ENST00000351223	NASP-202	1538	XM_005270889	ENSP00000255121	449 (aa)	XP_005270946	P49321
ENST00000453748	NASP-206	2080	-	ENSP00000403157	38 (aa)	-	E9PAU3
ENST00000528084	NASP-215	535	-	ENSP00000435363	56 (aa)	-	E9PKR5
ENST00000529333	NASP-217	778	-	ENSP00000436388	38 (aa)	-	E9PAU3
ENST00000437901	NASP-205	874	-	ENSP00000400792	256 (aa)	-	E9PI86
ENST00000629893	NASP-225	253	-	ENSP00000486336	56 (aa)	-	E9PKR5
ENST00000537798	NASP-224	3097	-	ENSP00000438871	724 (aa)	-	P49321
ENST00000534101	NASP-222	754	-	-	- (aa)	-	-
ENST00000527359	NASP-212	743	-	ENSP00000436790	37 (aa)	-	E9PQG5
ENST00000531612	NASP-221	938	-	ENSP00000437116	288 (aa)	-	H0YF33
ENST00000481782	NASP-210	3659	-	-	- (aa)	-	-
ENST00000472408	NASP-209	541	-	-	- (aa)	-	-
ENST00000437362	NASP-204	999	-	ENSP00000388010	38 (aa)	-	E9PAU3
ENST00000527932	NASP-214	650	-	-	- (aa)	-	-
ENST00000470768	NASP-208	1036	-	ENSP00000436924	316 (aa)	-	E9PPR5
ENST00000527470	NASP-213	532	-	ENSP00000437241	143 (aa)	-	E9PNB5
ENST00000528238	NASP-216	894	-	ENSP00000432289	268 (aa)	-	E9PRH9
ENST00000530840	NASP-219	531	-	ENSP00000435548	55 (aa)	-	E9PJQ2
ENST00000372052	NASP-203	1458	-	ENSP00000361122	422 (aa)	-	Q5T624
ENST00000534450	NASP-223	632	-	ENSP00000434240	175 (aa)	-	H0YDS9
ENST00000525515	NASP-211	565	-	ENSP00000436939	154 (aa)	-	E9PPQ8
ENST00000464190	NASP-207	604	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132780's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000132780	Metabolism	5E-11	24816252

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132780	rs1053941	1	45618711	T	Blood metabolite levels	24816252	[0.011-0.023] unit decrease	0.017	EFO_0005664
ENSG00000132780	rs72688441	1	45585381	A	Blood protein levels	29875488	[1.08-1.28] unit decrease	1.18	EFO_0007937
ENSG00000132780	rs2230657	1	45607817	A	Hemoglobin concentration	27863252	[0.019-0.033] unit decrease	0.02592878	EFO_0004509
ENSG00000132780	rs72688441	1	45585381	G	Blood protein levels	30072576	[1.18-1.35] unit increase	1.267	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132780's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132780	NASP	95	97.561	ENSMUSG00000028693	Nasp	99	95.620	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	-	ISS	Process
GO:0000790	nuclear chromatin	14718166.	IDA	Component
GO:0001824	blastocyst development	-	ISS	Process
GO:0005515	protein binding	16189514.19410544.20080577.21044950.29568061.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006260	DNA replication	-	ISS	Process
GO:0006335	DNA replication-dependent nucleosome assembly	21873635.	IBA	Process
GO:0006335	DNA replication-dependent nucleosome assembly	14718166.	IDA	Process
GO:0006336	DNA replication-independent nucleosome assembly	14718166.	IDA	Process
GO:0008283	cell proliferation	-	ISS	Process
GO:0008584	male gonad development	-	IEA	Process
GO:0015031	protein transport	-	IEA	Process
GO:0032991	protein-containing complex	14718166.	IDA	Component
GO:0033574	response to testosterone	-	IEA	Process
GO:0034080	CENP-A containing nucleosome assembly	21873635.	IBA	Process
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042393	histone binding	27618665.	IDA	Function
GO:0043486	histone exchange	-	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.